                      б

<110>  ϺҽҩƼ޹˾ż޹˾

<120>  SARS-CoV-2弰Ӧ

<130>  0134-PA-001

<160>  125

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  1

Arg Ala Ser Gln Gly Ile Ser Asn Ser Leu Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  2

Ala Ala Ser Arg Leu Glu Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  3

Gln Gln Ser Tyr Ser Thr Pro Ser Thr 
1               5                   


<210>  4
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Asn Ser 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu 
        35                  40                  45              


Tyr Ala Ala Ser Arg Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Ser 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  5
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  5

Ser Asn Tyr Met Ser 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  6

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  8
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  7

Glu Val Ser Asp Ala Phe Asp Ile 
1               5               


<210>  8
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Val Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  9
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  9

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  10
<211>  116
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Val Ser Asp Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  11

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  12
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  12

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  13
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  13

Gln Gln Tyr Gly Ser Ser Pro Gln Thr 
1               5                   


<210>  14
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  14

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro Gln 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  15
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  15

Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Arg Gly 
1               5                   10                  15      


<210>  16
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  16

Gly Asp Ile Gly Met Thr Arg Ile Tyr Gly Leu Glu Val 
1               5                   10              


<210>  17
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Arg 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val 
                85                  90                  95      


Arg Gly Asp Ile Gly Met Thr Arg Ile Tyr Gly Leu Glu Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  18

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  19
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  19

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  20

Gln Gln Tyr Asp Asn Leu Pro Leu Thr 
1               5                   


<210>  21
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  22

Ser Tyr Ala Ile Ser 
1               5   


<210>  23
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  23

Arg Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  24
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  24

Leu Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ile 
1               5                   10                  


<210>  25
<211>  123
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  25

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Ala Ser Tyr Ser Ser Gly Trp Glu Asp Val Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120             


<210>  26
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  26

Arg Ala Ser Gln Ser Val Ser Gly Ser Tyr Leu Ala 
1               5                   10          


<210>  27
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  27

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  28
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  28

Gln Gln Tyr Asp Ser Ser Pro Val Thr 
1               5                   


<210>  29
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  29

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Gly Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Val Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  30
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  30

Ser Phe Asp Ile Asn 
1               5   


<210>  31
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  31

Trp Met His Ala Ser Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  32
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  32

Tyr Val Pro His Asp Ala Phe Gln Ile 
1               5                   


<210>  33
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ala Ser Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Asp Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  34
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  34

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  35
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  35

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  36
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  36

Gln Gln Tyr Asp Ser Ser Pro Ile Thr 
1               5                   


<210>  37
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  37

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  38
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  38

Trp Met His Ala Gly Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  39
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  39

Tyr Val Pro His Gly Ala Phe Gln Ile 
1               5                   


<210>  40
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  40

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser Ser Phe 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Met His Ala Gly Ser Gly Asn Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Asn Tyr Val Pro His Gly Ala Phe Gln Ile Trp Gly Gln Gly Thr 
            100                 105                 110         


Met Val Thr Val Ser Ser 
        115             


<210>  41
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  41

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  42

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  43
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  43

Gln Gln Ser Tyr Ser Thr Pro Pro Ile Thr 
1               5                   10  


<210>  44
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105             


<210>  45
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  45

Asn Ser Asp Met His 
1               5   


<210>  46
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  46

Ala Ile Gly Asp Ser Gly Asp Thr Tyr Tyr Ser Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  47
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  47

Ala Ala Asn Trp Gly Trp Asp Trp Tyr Phe Asp Leu 
1               5                   10          


<210>  48
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser Asn Ser 
            20                  25                  30          


Asp Met His Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Asp Ser Gly Asp Thr Tyr Tyr Ser Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Ala Asn Trp Gly Trp Asp Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  49
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  49

Asp Ala Gly Pro Tyr Gly Met Asp Val 
1               5                   


<210>  50
<211>  117
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  50

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Ala Gly Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  51
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  51

Ser Asn Tyr Met Thr 
1               5   


<210>  52
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  52

Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  53
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  53

Asp Leu Pro Val Gly Gly Val Asp Ala Phe Asp Ile 
1               5                   10          


<210>  54
<211>  120
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  54

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Ile Ser Ser Asn 
            20                  25                  30          


Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Leu Pro Val Gly Gly Val Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  55
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  55

Asn Tyr Asp Met Phe 
1               5   


<210>  56
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  56

Ala Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  57
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  57

Gly Gly Asp Ala Pro Met Val Gly Trp His Phe Asp Val 
1               5                   10              


<210>  58
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  58

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Gly Asp Ala Pro Met Val Gly Trp His Phe Asp Val Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  59

Gln Ala Ser Gln Asp Ile Asn Asn Tyr Leu Asn 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  60

Ala Ala Ser Asn Leu Glu Thr 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR3

<400>  61

Gln Gln Tyr Asp Asn Leu Pro Ile Thr 
1               5                   


<210>  62
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Ile 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
            100                 105         


<210>  63
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  63

Ser Ser Gly Met Thr 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  64

Tyr Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  65

Gly Gly Gly Phe Leu Trp Phe Gly Glu Phe 
1               5                   10  


<210>  66
<211>  119
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  66

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser 
            20                  25                  30          


Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Gly Gly Phe Leu Trp Phe Gly Glu Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  67
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  67

Ile Ile Tyr Pro Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  68
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  68

Glu Thr Pro Asn Ala Gly Ser Leu Asp Tyr 
1               5                   10  


<210>  69
<211>  118
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  69

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser Ser Asn 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ile Ile Tyr Pro Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Glu Thr Pro Asn Ala Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  70
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  70

Gly Gly Val Ala Pro Met Ala Gly Trp His Phe Asp Leu 
1               5                   10              


<210>  71
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  71

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Phe Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Gly Val Ala Pro Met Ala Gly Trp His Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  72
<211>  13
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  72

Gly Gly Ile Ala Ala Met Val Gly Trp His Phe Asp Leu 
1               5                   10              


<210>  73
<211>  121
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Asp Met Phe Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Gly Pro Ala Gly Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Ile Ala Ala Met Val Gly Trp His Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR1

<400>  74

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  75
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR1

<400>  75

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys 
            20              


<210>  76
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2

<400>  76

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Leu Tyr 
1               5                   10                  15  


<210>  77
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2

<400>  77

Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  78
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR2

<400>  78

Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  79
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3

<400>  79

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  80
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3

<400>  80

Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  81
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3

<400>  81

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  82
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR3

<400>  82

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  83
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR4

<400>  83

Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR4

<400>  84

Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR4

<400>  85

Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LFR4

<400>  86

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  87
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  87

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  88
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  88

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser 
            20                  25                  30  


<210>  89
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Asp Thr Phe Ser 
            20                  25                  30  


<210>  90
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  90

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Ser 
            20                  25                  30  


<210>  91
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  91

Glu Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser 
            20                  25                  30  


<210>  92
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  92

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Ser Ile Ser 
            20                  25                  30  


<210>  93
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  93

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  94
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR1

<400>  94

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Thr Val Ser 
            20                  25                  30  


<210>  95
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2

<400>  95

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  96
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2

<400>  96

Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  97
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2

<400>  97

Trp Val Arg Gln Ala Thr Gly Gln Gly Leu Glu Trp Met Gly 
1               5                   10                  


<210>  98
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR2

<400>  98

Trp Val Arg Gln Ala Thr Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  99
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  99

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  100
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  100

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Val Arg 
            20                  25                  30          


<210>  101
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  101

Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
            20                  25                  30          


<210>  102
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  102

Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asn 
            20                  25                  30          


<210>  103
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  103

Arg Phe Thr Ile Ser Arg Glu Asn Ala Lys Ser Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  104
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  104

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  105
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  105

Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  106
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR3

<400>  106

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 
            20                  25                  30          


<210>  107
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4

<400>  107

Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4

<400>  108

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4

<400>  109

Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HFR4

<400>  110

Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  111
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR1

<400>  111

Arg Ala Ser Arg Pro Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  112
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  LCDR2

<400>  112

Ser Val Ser Arg Leu Gln Ser 
1               5           


<210>  113
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VL

<400>  113

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Val Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asn Leu Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  114
<211>  5
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR1

<400>  114

Asp Tyr Ala Met Ser 
1               5   


<210>  115
<211>  19
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR2

<400>  115

Ser Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  116
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  HCDR3

<400>  116

His Arg Tyr Asp Ser Ser Gly Tyr Tyr Pro Gly Pro Gly Phe Asp Tyr 
1               5                   10                  15      


<210>  117
<211>  127
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  VH

<400>  117

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ser Ile Arg Ser Lys Ala Tyr Gly Gly Thr Thr Glu Tyr Ala Ala 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ile 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Glu His Arg Tyr Asp Ser Ser Gly Tyr Tyr Pro Gly Pro 
            100                 105                 110         


Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125         


<210>  118
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.02LCDR1; Ab2001.03LCDR1; Ab2001.11LCDR1; Ab2001.12LCDR1; Ab2001.13LCDR1; Ab2001.14LCDR1; Ab2001.23LCDR1; Ab2001.24LCDR1; Ab2001.25LCDR1; Ab2001.16LCDR1

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AlaAsn

<400>  118

Arg Ala Ser Gln Xaa Ile Ser Xaa Xaa Leu Xaa 
1               5                   10      


<210>  119
<211>  12
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.04LCDR1; Ab2001.08LCDR1; Ab2001.09LCDR1; Ab2001.10LCDR1; Ab2001.19LCDR1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = GlnArg

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AspGlySer

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = GlyAsnSer

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = SerTrpTyr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = LeuTyr

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = AlaLeuAsn

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Ala򲻴

<400>  119

Xaa Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  120
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.02LCDR2; Ab2001.03LCDR2; Ab2001.11LCDR2; Ab2001.12LCDR2; Ab2001.13LCDR2; Ab2001.14LCDR2; Ab2001.23LCDR2; Ab2001.24LCDR2; Ab2001.25LCDR2; Ab2001.16LCDR2

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = GluGln

<400>  120

Ala Ala Ser Xaa Leu Xaa Ser 
1               5           


<210>  121
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.04LCDR2; Ab2001.08LCDR2; Ab2001.09LCDR2; Ab2001.10LCDR2; Ab2001.19LCDR2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AlaAspGly

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AsnSerThr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = AlaGlu

<400>  121

Xaa Ala Ser Xaa Xaa Xaa Thr 
1               5           


<210>  122
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.02LCDR3; Ab2001.03LCDR3; Ab2001.11LCDR3; Ab2001.12LCDR3; Ab2001.13LCDR3; Ab2001.14LCDR3; Ab2001.23LCDR3; Ab2001.24LCDR3; Ab2001.25LCDR3; Ab2001.16LCDR3

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = IleThr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Thr򲻴

<400>  122

Gln Gln Ser Tyr Ser Thr Pro Xaa Xaa Xaa 
1               5                   10  


<210>  123
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.04LCDR3; Ab2001.08LCDR3; Ab2001.07LCDR3; Ab2001.09LCDR3; Ab2001.10LCDR3; Ab2001.19LCDR3

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = LeuSer

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = IleLeuGlnVal

<400>  123

Gln Gln Tyr Xaa Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  124
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.02VL; Ab2001.03VL; Ab2001.11VL; Ab2001.12VL; Ab2001.13VL; Ab2001.14VL; Ab2001.23VL; Ab2001.24VL; Ab2001.25VL; Ab2001.16VL

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = SerTyr

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = AlaAsn

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = PheTyr

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa = ProSer

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = Ile򲻴

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = LeuVal

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Xaa Ile Ser Xaa Xaa 
            20                  25                  30          


Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Xaa 
        35                  40                  45              


Tyr Ala Ala Ser Xaa Leu Xaa Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Xaa 
                85                  90                  95      


Xaa Thr Phe Gly Gln Gly Thr Xaa Xaa Glu Ile Lys 
            100                 105             


<210>  125
<211>  108
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Ab2001.04VL; Ab2001.08VL; Ab2001.09VL; Ab2001.10VL; Ab2001.19VL

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = GlnVal

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = LeuMet

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = GlySer

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = AlaLeu

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = ProVal

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = AspGlu

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa = AlaVal

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = IleLeu

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = SerThr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = GlnArg

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = AspGlySer

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa = 

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = GlyAsnSer

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa = Ser򲻴

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = TrpTyr

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa = AlaAsn

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = LysGln

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa = AlaAspGly

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = AsnSerThr

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = LeuArg

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = AlaGlu

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = IleVal

<220>
<221>  misc_feature
<222>  (61)..(61)
<223>  Xaa = AspSer

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa = PheLeu

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = ArgSer

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = GluGln

<220>
<221>  misc_feature
<222>  (84).(84)
<223>  Xaa = PheIle

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa = ThrVal

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = AspGly

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa = AsnSer

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa = LeuSer

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa = IleLeuGlnVal

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa = GlyGln

<220>
<221>  misc_feature
<222>  (104)..(104)
<223>  Xaa = LysArg

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = LeuVal

<400>  125

Xaa Ile Xaa Xaa Thr Gln Ser Pro Xaa Xaa Leu Ser Xaa Ser Xaa Gly 
1               5                   10                  15      


Xaa Arg Xaa Thr Xaa Xaa Cys Xaa Ala Ser Gln Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Xaa Trp Tyr Gln Gln Lys Pro Gly Xaa Ala Pro Xaa Leu Leu 
        35                  40                  45              


Ile Tyr Xaa Ala Ser Xaa Xaa Xaa Thr Gly Xaa Pro Xaa Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Xaa Thr Ile Ser Xaa Leu Xaa 
65                  70                  75                  80  


Pro Glu Asp Xaa Ala Xaa Tyr Tyr Cys Gln Gln Tyr Xaa Xaa Xaa Pro 
                85                  90                  95      


Xaa Thr Phe Gly Xaa Gly Thr Xaa Xaa Glu Ile Lys 
            100                 105             