                         SEQUENCE LISTING

<110>  Exopharm Limited
 
<120>  Anti-viral extracellular vesicles, their methods of preparation 
       and uses

<130>  53116922AZD

<150>  AU 2020901723
<151>  2020-05-27

<160>  75    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Cytomegalovirus

<400>  1
cgcaaatggg cggtaggcgt g                                                 21


<210>  2
<211>  21
<212>  DNA
<213>  Epstein-Barr virus

<400>  2
gatgagtttg gacaaacgca c                                                 21


<210>  3
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VSVG signal Sequence

<400>  3
gcaccggtgc aattcacccc aatggataaa aaagctaagt acaaaaggca cttcatctgc       60

aggc                                                                    64


<210>  4
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VSVG signal Sequence

<400>  4
gcctgcagat gaagtgcctt ttgtacttag cttttttatc cattggggtg aattgcaccg       60

gtgc                                                                    64


<210>  5
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VSVG signal Sequence

<400>  5
gcgggcccgc aattcacccc aatggataaa aaagctaagt acaaaaggca cttcatgagc       60

tcgc                                                                    64


<210>  6
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VSVG signal Sequence

<400>  6
gcgagctcat gaagtgcctt ttgtacttag cttttttatc cattggggtg aattgcgggc       60

ccgc                                                                    64


<210>  7
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length VSVG ecto

<400>  7
cggagctcat gaagtgcctt ttg                                               23


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length VSVG ecto

<400>  8
cggggccccc tttccaagtc                                                   20


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length CoVS ecto

<400>  9
gcgagctcat gtttgtgttc ctgg                                              24


<210>  10
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full length CoVS ecto

<400>  10
gcgggccctg gccacttgat gtattg                                            26


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AcGFP

<400>  11
gcaccggtgt gagcaagggc                                                   20


<210>  12
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AcGFP

<400>  12
gcgcggccgc cttgtacagc tcatccatg                                         29


<210>  13
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal VSVG domain

<400>  13
gcgggccctt cgaacatcct cacattc                                           27


<210>  14
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal VSVG domain

<400>  14
gcaccggtct ttccaagtcg gttcatc                                           27


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AcGFP

<400>  15
gcaccggtgt gagcaagggc                                                   20


<210>  16
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AcGFP

<400>  16
gcgcggccgc tcacttg                                                      17


<210>  17
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal VSVG domain

<400>  17
gcgcggccgc cttcgaacat cctcacattc                                        30


<210>  18
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Minimal VSVG domain

<400>  18
gccaattgtt actttccaag tcggttcatc tctatgtc                               38


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DsRed

<400>  19
gcaccggtga caacaccgag gacgtc                                            26


<210>  20
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DsRed

<400>  20
gcgcggccgc tctactggga gcc                                               23


<210>  21
<211>  1273
<212>  PRT
<213>  SARS-CoV-2

<400>  21

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  22
<211>  223
<212>  PRT
<213>  SARS-CoV-2

<400>  22

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  23
<211>  672
<212>  PRT
<213>  SARS-CoV-2

<400>  23

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
225                 230                 235                 240 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
                245                 250                 255     


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
        275                 280                 285             


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
    290                 295                 300                 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
305                 310                 315                 320 


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
                325                 330                 335     


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            340                 345                 350         


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        355                 360                 365             


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    370                 375                 380                 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                405                 410                 415     


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            420                 425                 430         


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        435                 440                 445             


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    450                 455                 460                 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
465                 470                 475                 480 


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                485                 490                 495     


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            500                 505                 510         


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
        515                 520                 525             


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
    530                 535                 540                 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
545                 550                 555                 560 


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
                565                 570                 575     


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
            580                 585                 590         


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
        595                 600                 605             


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
    610                 615                 620                 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
625                 630                 635                 640 


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
                645                 650                 655     


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
            660                 665                 670         


<210>  24
<211>  549
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  24

Met Phe Met Pro Ser Ser Leu Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Asn Ser Ser Thr Asp Pro 
            20                  25                  30          


Ser Arg Asn Ser Asp Thr Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu 
        35                  40                  45              


Phe Ile Gly Val Asn Cys Lys Phe Thr Ile Val Phe Pro His Asn Gln 
    50                  55                  60                  


Lys Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser 
65                  70                  75                  80  


Ser Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Leu Gln 
                85                  90                  95      


Val Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met 
            100                 105                 110         


Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly 
        115                 120                 125             


Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu 
    130                 135                 140                 


Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn 
145                 150                 155                 160 


Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala 
                165                 170                 175     


Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu 
            180                 185                 190         


Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser 
        195                 200                 205             


Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp 
    210                 215                 220                 


Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Ile Ser Met Asp Ile 
225                 230                 235                 240 


Thr Phe Phe Ser Glu Asp Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly 
                245                 250                 255     


Thr Gly Phe Arg Ser Asn Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala 
            260                 265                 270         


Cys Lys Met Gln Tyr Cys Lys His Trp Gly Val Arg Leu Pro Ser Gly 
        275                 280                 285             


Val Trp Phe Glu Met Ala Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe 
    290                 295                 300                 


Pro Glu Cys Pro Glu Gly Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser 
305                 310                 315                 320 


Val Asp Val Ser Leu Ile Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser 
                325                 330                 335     


Leu Cys Gln Glu Thr Trp Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser 
            340                 345                 350         


Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro 
        355                 360                 365             


Ala Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr 
    370                 375                 380                 


Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met 
385                 390                 395                 400 


Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro 
                405                 410                 415     


Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Ser 
            420                 425                 430         


Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser 
        435                 440                 445             


Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile 
    450                 455                 460                 


Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly 
465                 470                 475                 480 


Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe 
                485                 490                 495     


Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu 
            500                 505                 510         


Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile 
        515                 520                 525             


Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
    530                 535                 540                 


Asn Arg Leu Gly Lys 
545                 


<210>  25
<211>  511
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  25

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn 
            20                  25                  30          


Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp 
        35                  40                  45              


His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser 
    50                  55                  60                  


His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp 
65                  70                  75                  80  


Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His 
                85                  90                  95      


Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile 
            100                 105                 110         


Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln 
        115                 120                 125             


Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln 
    130                 135                 140                 


Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val 
145                 150                 155                 160 


Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr 
                165                 170                 175     


Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu 
            180                 185                 190         


Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp 
        195                 200                 205             


Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn 
    210                 215                 220                 


Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys 
225                 230                 235                 240 


Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala 
                245                 250                 255     


Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly 
            260                 265                 270         


Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile 
        275                 280                 285             


Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp 
    290                 295                 300                 


Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr 
305                 310                 315                 320 


Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn 
                325                 330                 335     


Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala 
            340                 345                 350         


Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr 
        355                 360                 365             


Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile 
    370                 375                 380                 


Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu 
385                 390                 395                 400 


Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser 
                405                 410                 415     


Lys Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln 
            420                 425                 430         


Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys 
        435                 440                 445             


Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser 
    450                 455                 460                 


Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu 
465                 470                 475                 480 


Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys 
                485                 490                 495     


Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            500                 505                 510     


<210>  26
<211>  91
<212>  PRT
<213>  Vesicular stomatitis virus

<400>  26

Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp 
1               5                   10                  15      


Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu 
            20                  25                  30          


Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe 
        35                  40                  45              


Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val 
    50                  55                  60                  


Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile 
65                  70                  75                  80  


Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                85                  90      


<210>  27
<211>  1283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S-protein signal peptide with SARS-CoV-2 S-protein 
       with VSVG fragment

<400>  27

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Gly Asp  Thr Gly Leu 
    1205                 1210                 1215             


Ser Lys  Asn Pro Ile Glu Leu  Val Glu Gly Trp Phe  Ser Ser Trp 
    1220                 1225                 1230             


Lys Ser  Ser Ile Ala Ser Phe  Phe Phe Ile Ile Gly  Leu Ile Ile 
    1235                 1240                 1245             


Gly Leu  Phe Leu Val Leu Arg  Val Gly Ile His Leu  Cys Ile Lys 
    1250                 1255                 1260             


Leu Lys  His Thr Lys Lys Arg  Gln Ile Tyr Thr Asp  Ile Glu Met 
    1265                 1270                 1275             


Asn Arg  Leu Gly Lys 
    1280             


<210>  28
<211>  1325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG derivative signal peptide with SARS-CoV-2 S-protein with 
       VSVG fragment

<400>  28

Met Phe Met Pro Ser Ser Leu Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Asn Ser Ser Thr Asp Pro 
            20                  25                  30          


Ser Arg Asn Ser Asp Thr Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu 
        35                  40                  45              


Phe Ile Gly Val Asn Cys Ser Gln Cys Val Asn Leu Thr Thr Arg Thr 
    50                  55                  60                  


Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
65                  70                  75                  80  


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
                85                  90                  95      


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
            100                 105                 110         


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
        115                 120                 125             


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
    130                 135                 140                 


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
145                 150                 155                 160 


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
                165                 170                 175     


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
            180                 185                 190         


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
        195                 200                 205             


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
    210                 215                 220                 


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
225                 230                 235                 240 


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
                245                 250                 255     


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
            260                 265                 270         


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
        275                 280                 285             


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
    290                 295                 300                 


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
305                 310                 315                 320 


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
                325                 330                 335     


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
            340                 345                 350         


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
        355                 360                 365             


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
    370                 375                 380                 


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
385                 390                 395                 400 


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
                405                 410                 415     


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
            420                 425                 430         


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
        435                 440                 445             


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
    450                 455                 460                 


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
465                 470                 475                 480 


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
                485                 490                 495     


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
            500                 505                 510         


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
        515                 520                 525             


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
    530                 535                 540                 


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
545                 550                 555                 560 


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
                565                 570                 575     


Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
            580                 585                 590         


Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly 
        595                 600                 605             


Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu 
    610                 615                 620                 


Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile 
625                 630                 635                 640 


Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp 
                645                 650                 655     


Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr 
            660                 665                 670         


Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg 
        675                 680                 685             


Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys 
    690                 695                 700                 


Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr 
705                 710                 715                 720 


Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala 
                725                 730                 735     


Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn 
            740                 745                 750         


Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile 
        755                 760                 765             


Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile 
    770                 775                 780                 


Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser 
785                 790                 795                 800 


Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln 
                805                 810                 815     


Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys 
            820                 825                 830         


Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu 
        835                 840                 845             


Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu 
    850                 855                 860                 


Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly 
865                 870                 875                 880 


Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys 
                885                 890                 895     


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile 
            900                 905                 910         


Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp 
        915                 920                 925             


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
    930                 935                 940                 


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
945                 950                 955                 960 


Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile 
                965                 970                 975     


Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp 
            980                 985                 990         


Val Val Asn Gln Asn Ala Gln Ala  Leu Asn Thr Leu Val  Lys Gln Leu 
        995                 1000                 1005             


Ser Ser  Asn Phe Gly Ala Ile  Ser Ser Val Leu Asn  Asp Ile Leu 
    1010                 1015                 1020             


Ser Arg  Leu Asp Lys Val Glu  Ala Glu Val Gln Ile  Asp Arg Leu 
    1025                 1030                 1035             


Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
    1040                 1045                 1050             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1055                 1060                 1065             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1070                 1075                 1080             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1085                 1090                 1095             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1100                 1105                 1110             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1115                 1120                 1125             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1130                 1135                 1140             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1145                 1150                 1155             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1160                 1165                 1170             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1175                 1180                 1185             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1190                 1195                 1200             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1205                 1210                 1215             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1220                 1225                 1230             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1235                 1240                 1245             


Glu Gln  Tyr Ile Lys Trp Pro  Gly Asp Thr Gly Leu  Ser Lys Asn 
    1250                 1255                 1260             


Pro Ile  Glu Leu Val Glu Gly  Trp Phe Ser Ser Trp  Lys Ser Ser 
    1265                 1270                 1275             


Ile Ala  Ser Phe Phe Phe Ile  Ile Gly Leu Ile Ile  Gly Leu Phe 
    1280                 1285                 1290             


Leu Val  Leu Arg Val Gly Ile  His Leu Cys Ile Lys  Leu Lys His 
    1295                 1300                 1305             


Thr Lys  Lys Arg Gln Ile Tyr  Thr Asp Ile Glu Met  Asn Arg Leu 
    1310                 1315                 1320             


Gly Lys  
    1325 


<210>  29
<211>  1287
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG WT signal peptide with SARS-CoV-2 S-protein with VSVG 
       fragment

<400>  29

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
            20                  25                  30          


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
        35                  40                  45              


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
    50                  55                  60                  


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
65                  70                  75                  80  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
                85                  90                  95      


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
            100                 105                 110         


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
        115                 120                 125             


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
    130                 135                 140                 


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
145                 150                 155                 160 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
                165                 170                 175     


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
        195                 200                 205             


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
    210                 215                 220                 


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
                245                 250                 255     


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
            260                 265                 270         


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
        275                 280                 285             


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
    290                 295                 300                 


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
305                 310                 315                 320 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
                325                 330                 335     


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            340                 345                 350         


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        355                 360                 365             


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    370                 375                 380                 


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                405                 410                 415     


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            420                 425                 430         


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        435                 440                 445             


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
    450                 455                 460                 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
                485                 490                 495     


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            500                 505                 510         


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        515                 520                 525             


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    530                 535                 540                 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
545                 550                 555                 560 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
                565                 570                 575     


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
            580                 585                 590         


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
        595                 600                 605             


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
    610                 615                 620                 


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
625                 630                 635                 640 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
                645                 650                 655     


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
            660                 665                 670         


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
        675                 680                 685             


Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly 
    690                 695                 700                 


Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr 
705                 710                 715                 720 


Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr 
                725                 730                 735     


Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu 
            740                 745                 750         


Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn 
        755                 760                 765             


Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu 
    770                 775                 780                 


Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp 
785                 790                 795                 800 


Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro 
                805                 810                 815     


Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu 
            820                 825                 830         


Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile 
        835                 840                 845             


Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val 
    850                 855                 860                 


Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala 
865                 870                 875                 880 


Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala 
                885                 890                 895     


Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly 
            900                 905                 910         


Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala 
        915                 920                 925             


Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser 
    930                 935                 940                 


Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala 
945                 950                 955                 960 


Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala 
                965                 970                 975     


Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu 
            980                 985                 990         


Ala Glu Val Gln Ile Asp Arg Leu  Ile Thr Gly Arg Leu  Gln Ser Leu 
        995                 1000                 1005             


Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg 
    1010                 1015                 1020             


Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu 
    1025                 1030                 1035             


Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu 
    1040                 1045                 1050             


Met Ser  Phe Pro Gln Ser Ala  Pro His Gly Val Val  Phe Leu His 
    1055                 1060                 1065             


Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro 
    1070                 1075                 1080             


Ala Ile  Cys His Asp Gly Lys  Ala His Phe Pro Arg  Glu Gly Val 
    1085                 1090                 1095             


Phe Val  Ser Asn Gly Thr His  Trp Phe Val Thr Gln  Arg Asn Phe 
    1100                 1105                 1110             


Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly 
    1115                 1120                 1125             


Asn Cys  Asp Val Val Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp 
    1130                 1135                 1140             


Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys 
    1145                 1150                 1155             


Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile 
    1160                 1165                 1170             


Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp 
    1175                 1180                 1185             


Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp 
    1190                 1195                 1200             


Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Gly 
    1205                 1210                 1215             


Asp Thr  Gly Leu Ser Lys Asn  Pro Ile Glu Leu Val  Glu Gly Trp 
    1220                 1225                 1230             


Phe Ser  Ser Trp Lys Ser Ser  Ile Ala Ser Phe Phe  Phe Ile Ile 
    1235                 1240                 1245             


Gly Leu  Ile Ile Gly Leu Phe  Leu Val Leu Arg Val  Gly Ile His 
    1250                 1255                 1260             


Leu Cys  Ile Lys Leu Lys His  Thr Lys Lys Arg Gln  Ile Tyr Thr 
    1265                 1270                 1275             


Asp Ile  Glu Met Asn Arg Leu  Gly Lys 
    1280                 1285         


<210>  30
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S-protein signal peptide with SARS-CoV-2 S-protein 
       receptor binding domain with VSVG fragment

<400>  30

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Arg Val Gln Pro 
1               5                   10                  15      


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
            20                  25                  30          


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
        35                  40                  45              


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
    50                  55                  60                  


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
65                  70                  75                  80  


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
                85                  90                  95      


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
            100                 105                 110         


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
        115                 120                 125             


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
    130                 135                 140                 


Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
145                 150                 155                 160 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly 
                165                 170                 175     


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
            180                 185                 190         


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
        195                 200                 205             


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
    210                 215                 220                 


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly Asp Thr Gly Leu 
225                 230                 235                 240 


Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys 
                245                 250                 255     


Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu 
            260                 265                 270         


Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His 
        275                 280                 285             


Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly 
    290                 295                 300                 


Lys 
305 


<210>  31
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG derivative signal peptide with SARS-CoV-2 S-protein receptor
       binding domain with VSVG fragment

<400>  31

Met Phe Met Pro Ser Ser Leu Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Asn Ser Ser Thr Asp Pro 
            20                  25                  30          


Ser Arg Asn Ser Asp Thr Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu 
        35                  40                  45              


Phe Ile Gly Val Asn Cys Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
    50                  55                  60                  


Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
65                  70                  75                  80  


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
                85                  90                  95      


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
            100                 105                 110         


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
        115                 120                 125             


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
    130                 135                 140                 


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
145                 150                 155                 160 


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
                165                 170                 175     


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
            180                 185                 190         


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
        195                 200                 205             


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
    210                 215                 220                 


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
225                 230                 235                 240 


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
                245                 250                 255     


Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn 
            260                 265                 270         


Lys Cys Val Asn Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu 
        275                 280                 285             


Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe 
    290                 295                 300                 


Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val 
305                 310                 315                 320 


Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile 
                325                 330                 335     


Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
            340                 345         


<210>  32
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG WT signal peptide with SARS-CoV-2 S-protein receptor binding
       domain with VSVG fragment

<400>  32

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
            20                  25                  30          


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
        35                  40                  45              


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
    50                  55                  60                  


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
65                  70                  75                  80  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
                85                  90                  95      


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
            100                 105                 110         


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
        115                 120                 125             


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
    130                 135                 140                 


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
145                 150                 155                 160 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
                165                 170                 175     


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
            180                 185                 190         


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
        195                 200                 205             


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
    210                 215                 220                 


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
225                 230                 235                 240 


Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe 
                245                 250                 255     


Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu 
            260                 265                 270         


Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile 
        275                 280                 285             


Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met 
    290                 295                 300                 


Asn Arg Leu Gly Lys 
305                 


<210>  33
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S-protein signal peptide with SARS-CoV-2 S-protein S1 
       domain with VSVG fragment

<400>  33

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Gly Asp Thr 
        675                 680                 685             


Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser 
    690                 695                 700                 


Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile 
705                 710                 715                 720 


Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu 
                725                 730                 735     


Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg 
            740                 745                 750         


Leu Gly Lys 
        755 


<210>  34
<211>  797
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG derivative signal peptide with SARS-CoV-2 S-protein S1 
       domain with VSVG fragment

<400>  34

Met Phe Met Pro Ser Ser Leu Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Asn Ser Ser Thr Asp Pro 
            20                  25                  30          


Ser Arg Asn Ser Asp Thr Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu 
        35                  40                  45              


Phe Ile Gly Val Asn Cys Ser Gln Cys Val Asn Leu Thr Thr Arg Thr 
    50                  55                  60                  


Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
65                  70                  75                  80  


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
                85                  90                  95      


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
            100                 105                 110         


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
        115                 120                 125             


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
    130                 135                 140                 


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
145                 150                 155                 160 


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
                165                 170                 175     


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
            180                 185                 190         


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
        195                 200                 205             


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
    210                 215                 220                 


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
225                 230                 235                 240 


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
                245                 250                 255     


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
            260                 265                 270         


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
        275                 280                 285             


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
    290                 295                 300                 


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
305                 310                 315                 320 


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
                325                 330                 335     


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
            340                 345                 350         


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
        355                 360                 365             


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
    370                 375                 380                 


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
385                 390                 395                 400 


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
                405                 410                 415     


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
            420                 425                 430         


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
        435                 440                 445             


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
    450                 455                 460                 


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
465                 470                 475                 480 


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
                485                 490                 495     


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
            500                 505                 510         


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
        515                 520                 525             


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
    530                 535                 540                 


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
545                 550                 555                 560 


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
                565                 570                 575     


Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
            580                 585                 590         


Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly 
        595                 600                 605             


Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu 
    610                 615                 620                 


Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile 
625                 630                 635                 640 


Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp 
                645                 650                 655     


Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr 
            660                 665                 670         


Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg 
        675                 680                 685             


Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys 
    690                 695                 700                 


Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr 
705                 710                 715                 720 


Asn Ser Pro Arg Arg Ala Arg Gly Asp Thr Gly Leu Ser Lys Asn Pro 
                725                 730                 735     


Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala 
            740                 745                 750         


Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu 
        755                 760                 765             


Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg 
    770                 775                 780                 


Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
785                 790                 795         


<210>  35
<211>  759
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG WT signal peptide with SARS-CoV-2 S-protein S1 domain with 
       VSVG fragment

<400>  35

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
            20                  25                  30          


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
        35                  40                  45              


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
    50                  55                  60                  


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
65                  70                  75                  80  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
                85                  90                  95      


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
            100                 105                 110         


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
        115                 120                 125             


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
    130                 135                 140                 


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
145                 150                 155                 160 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
                165                 170                 175     


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
        195                 200                 205             


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
    210                 215                 220                 


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
                245                 250                 255     


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
            260                 265                 270         


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
        275                 280                 285             


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
    290                 295                 300                 


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
305                 310                 315                 320 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
                325                 330                 335     


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            340                 345                 350         


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        355                 360                 365             


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    370                 375                 380                 


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                405                 410                 415     


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            420                 425                 430         


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        435                 440                 445             


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
    450                 455                 460                 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
                485                 490                 495     


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            500                 505                 510         


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        515                 520                 525             


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    530                 535                 540                 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
545                 550                 555                 560 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
                565                 570                 575     


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
            580                 585                 590         


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
        595                 600                 605             


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
    610                 615                 620                 


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
625                 630                 635                 640 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
                645                 650                 655     


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
            660                 665                 670         


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
        675                 680                 685             


Arg Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly 
    690                 695                 700                 


Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile 
705                 710                 715                 720 


Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu 
                725                 730                 735     


Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile 
            740                 745                 750         


Glu Met Asn Arg Leu Gly Lys 
        755                 


<210>  36
<211>  1180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S-protein signal peptide with S-protein receptor 
       binding domain with full length VSVG without VSVG signal peptide

<400>  36

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Lys Phe Thr 
        675                 680                 685             


Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn Val Pro Ser 
    690                 695                 700                 


Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp His Asn Asp 
705                 710                 715                 720 


Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser His Lys Ala 
                725                 730                 735     


Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr 
            740                 745                 750         


Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg 
        755                 760                 765             


Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr 
    770                 775                 780                 


Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly 
785                 790                 795                 800 


Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro 
                805                 810                 815     


His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln 
            820                 825                 830         


Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn 
        835                 840                 845             


Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser 
    850                 855                 860                 


Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp Gly Glu Leu 
865                 870                 875                 880 


Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn Tyr Phe Ala 
                885                 890                 895     


Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys Lys His Trp 
            900                 905                 910         


Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala Asp Lys Asp 
        915                 920                 925             


Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly Ser Ser Ile 
    930                 935                 940                 


Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile Gln Asp Val 
945                 950                 955                 960 


Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp Ser Lys Ile 
                965                 970                 975     


Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro 
            980                 985                 990         


Lys Asn Pro Gly Thr Gly Pro Ala  Phe Thr Ile Ile Asn  Gly Thr Leu 
        995                 1000                 1005             


Lys Tyr  Phe Glu Thr Arg Tyr  Ile Arg Val Asp Ile  Ala Ala Pro 
    1010                 1015                 1020             


Ile Leu  Ser Arg Met Val Gly  Met Ile Ser Gly Thr  Thr Thr Glu 
    1025                 1030                 1035             


Arg Glu  Leu Trp Asp Asp Trp  Ala Pro Tyr Glu Asp  Val Glu Ile 
    1040                 1045                 1050             


Gly Pro  Asn Gly Val Leu Arg  Thr Ser Ser Gly Tyr  Lys Phe Pro 
    1055                 1060                 1065             


Leu Tyr  Met Ile Gly His Gly  Met Leu Asp Ser Asp  Leu His Leu 
    1070                 1075                 1080             


Ser Ser  Lys Ala Gln Val Phe  Glu His Pro His Ile  Gln Asp Ala 
    1085                 1090                 1095             


Ala Ser  Gln Leu Pro Asp Asp  Glu Ser Leu Phe Phe  Gly Asp Thr 
    1100                 1105                 1110             


Gly Leu  Ser Lys Asn Pro Ile  Glu Leu Val Glu Gly  Trp Phe Ser 
    1115                 1120                 1125             


Ser Trp  Lys Ser Ser Ile Ala  Ser Phe Phe Phe Ile  Ile Gly Leu 
    1130                 1135                 1140             


Ile Ile  Gly Leu Phe Leu Val  Leu Arg Val Gly Ile  His Leu Cys 
    1145                 1150                 1155             


Ile Lys  Leu Lys His Thr Lys  Lys Arg Gln Ile Tyr  Thr Asp Ile 
    1160                 1165                 1170             


Glu Met  Asn Arg Leu Gly Lys  
    1175                 1180 


<210>  37
<211>  1222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG derivative signal peptide with S-protein S1 domain with full
       length VSVG without VSVG signal peptide

<400>  37

Met Phe Met Pro Ser Ser Leu Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Asn Ser Ser Thr Asp Pro 
            20                  25                  30          


Ser Arg Asn Ser Asp Thr Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu 
        35                  40                  45              


Phe Ile Gly Val Asn Cys Ser Gln Cys Val Asn Leu Thr Thr Arg Thr 
    50                  55                  60                  


Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
65                  70                  75                  80  


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
                85                  90                  95      


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
            100                 105                 110         


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
        115                 120                 125             


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
    130                 135                 140                 


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
145                 150                 155                 160 


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
                165                 170                 175     


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
            180                 185                 190         


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
        195                 200                 205             


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
    210                 215                 220                 


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
225                 230                 235                 240 


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
                245                 250                 255     


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
            260                 265                 270         


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
        275                 280                 285             


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
    290                 295                 300                 


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
305                 310                 315                 320 


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
                325                 330                 335     


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
            340                 345                 350         


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
        355                 360                 365             


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
    370                 375                 380                 


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
385                 390                 395                 400 


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
                405                 410                 415     


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
            420                 425                 430         


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
        435                 440                 445             


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
    450                 455                 460                 


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
465                 470                 475                 480 


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
                485                 490                 495     


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
            500                 505                 510         


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
        515                 520                 525             


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
    530                 535                 540                 


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
545                 550                 555                 560 


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
                565                 570                 575     


Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
            580                 585                 590         


Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly 
        595                 600                 605             


Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu 
    610                 615                 620                 


Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile 
625                 630                 635                 640 


Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp 
                645                 650                 655     


Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr 
            660                 665                 670         


Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg 
        675                 680                 685             


Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys 
    690                 695                 700                 


Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr 
705                 710                 715                 720 


Asn Ser Pro Arg Arg Ala Arg Lys Phe Thr Ile Val Phe Pro His Asn 
                725                 730                 735     


Gln Lys Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro 
            740                 745                 750         


Ser Ser Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Leu 
        755                 760                 765             


Gln Val Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp 
    770                 775                 780                 


Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr 
785                 790                 795                 800 


Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val 
                805                 810                 815     


Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu 
            820                 825                 830         


Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp 
        835                 840                 845             


Ala Glu Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp 
    850                 855                 860                 


Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys 
865                 870                 875                 880 


Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser 
                885                 890                 895     


Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Ile Ser Met Asp 
            900                 905                 910         


Ile Thr Phe Phe Ser Glu Asp Gly Glu Leu Ser Ser Leu Gly Lys Glu 
        915                 920                 925             


Gly Thr Gly Phe Arg Ser Asn Tyr Phe Ala Tyr Glu Thr Gly Gly Lys 
    930                 935                 940                 


Ala Cys Lys Met Gln Tyr Cys Lys His Trp Gly Val Arg Leu Pro Ser 
945                 950                 955                 960 


Gly Val Trp Phe Glu Met Ala Asp Lys Asp Leu Phe Ala Ala Ala Arg 
                965                 970                 975     


Phe Pro Glu Cys Pro Glu Gly Ser Ser Ile Ser Ala Pro Ser Gln Thr 
            980                 985                 990         


Ser Val Asp Val Ser Leu Ile Gln  Asp Val Glu Arg Ile  Leu Asp Tyr 
        995                 1000                 1005             


Ser Leu  Cys Gln Glu Thr Trp  Ser Lys Ile Arg Ala  Gly Leu Pro 
    1010                 1015                 1020             


Ile Ser  Pro Val Asp Leu Ser  Tyr Leu Ala Pro Lys  Asn Pro Gly 
    1025                 1030                 1035             


Thr Gly  Pro Ala Phe Thr Ile  Ile Asn Gly Thr Leu  Lys Tyr Phe 
    1040                 1045                 1050             


Glu Thr  Arg Tyr Ile Arg Val  Asp Ile Ala Ala Pro  Ile Leu Ser 
    1055                 1060                 1065             


Arg Met  Val Gly Met Ile Ser  Gly Thr Thr Thr Glu  Arg Glu Leu 
    1070                 1075                 1080             


Trp Asp  Asp Trp Ala Pro Tyr  Glu Asp Val Glu Ile  Gly Pro Asn 
    1085                 1090                 1095             


Gly Val  Leu Arg Thr Ser Ser  Gly Tyr Lys Phe Pro  Leu Tyr Met 
    1100                 1105                 1110             


Ile Gly  His Gly Met Leu Asp  Ser Asp Leu His Leu  Ser Ser Lys 
    1115                 1120                 1125             


Ala Gln  Val Phe Glu His Pro  His Ile Gln Asp Ala  Ala Ser Gln 
    1130                 1135                 1140             


Leu Pro  Asp Asp Glu Ser Leu  Phe Phe Gly Asp Thr  Gly Leu Ser 
    1145                 1150                 1155             


Lys Asn  Pro Ile Glu Leu Val  Glu Gly Trp Phe Ser  Ser Trp Lys 
    1160                 1165                 1170             


Ser Ser  Ile Ala Ser Phe Phe  Phe Ile Ile Gly Leu  Ile Ile Gly 
    1175                 1180                 1185             


Leu Phe  Leu Val Leu Arg Val  Gly Ile His Leu Cys  Ile Lys Leu 
    1190                 1195                 1200             


Lys His  Thr Lys Lys Arg Gln  Ile Tyr Thr Asp Ile  Glu Met Asn 
    1205                 1210                 1215             


Arg Leu  Gly Lys 
    1220         


<210>  38
<211>  1184
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG WT signal peptide with S-protein S1 domain with full length 
       VSVG without VSVG signal peptide

<400>  38

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
            20                  25                  30          


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
        35                  40                  45              


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
    50                  55                  60                  


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
65                  70                  75                  80  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
                85                  90                  95      


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
            100                 105                 110         


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
        115                 120                 125             


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
    130                 135                 140                 


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
145                 150                 155                 160 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
                165                 170                 175     


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
            180                 185                 190         


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
        195                 200                 205             


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
    210                 215                 220                 


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
225                 230                 235                 240 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
                245                 250                 255     


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
            260                 265                 270         


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
        275                 280                 285             


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
    290                 295                 300                 


Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser 
305                 310                 315                 320 


Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile 
                325                 330                 335     


Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
            340                 345                 350         


Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
        355                 360                 365             


Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
    370                 375                 380                 


Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
385                 390                 395                 400 


Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
                405                 410                 415     


Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
            420                 425                 430         


Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
        435                 440                 445             


Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
    450                 455                 460                 


Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
465                 470                 475                 480 


Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
                485                 490                 495     


Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
            500                 505                 510         


Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
        515                 520                 525             


Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn 
    530                 535                 540                 


Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn 
545                 550                 555                 560 


Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr 
                565                 570                 575     


Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr 
            580                 585                 590         


Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr 
        595                 600                 605             


Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val 
    610                 615                 620                 


Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr 
625                 630                 635                 640 


Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly 
                645                 650                 655     


Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala 
            660                 665                 670         


Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala 
        675                 680                 685             


Arg Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys 
    690                 695                 700                 


Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn 
705                 710                 715                 720 


Trp His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys 
                725                 730                 735     


Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys 
            740                 745                 750         


Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr 
        755                 760                 765             


His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser 
    770                 775                 780                 


Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro 
785                 790                 795                 800 


Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val 
                805                 810                 815     


Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp 
            820                 825                 830         


Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro 
        835                 840                 845             


Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly 
    850                 855                 860                 


Leu Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu 
865                 870                 875                 880 


Asp Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser 
                885                 890                 895     


Asn Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr 
            900                 905                 910         


Cys Lys His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met 
        915                 920                 925             


Ala Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu 
    930                 935                 940                 


Gly Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu 
945                 950                 955                 960 


Ile Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr 
                965                 970                 975     


Trp Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser 
            980                 985                 990         


Tyr Leu Ala Pro Lys Asn Pro Gly  Thr Gly Pro Ala Phe  Thr Ile Ile 
        995                 1000                 1005             


Asn Gly  Thr Leu Lys Tyr Phe  Glu Thr Arg Tyr Ile  Arg Val Asp 
    1010                 1015                 1020             


Ile Ala  Ala Pro Ile Leu Ser  Arg Met Val Gly Met  Ile Ser Gly 
    1025                 1030                 1035             


Thr Thr  Thr Glu Arg Glu Leu  Trp Asp Asp Trp Ala  Pro Tyr Glu 
    1040                 1045                 1050             


Asp Val  Glu Ile Gly Pro Asn  Gly Val Leu Arg Thr  Ser Ser Gly 
    1055                 1060                 1065             


Tyr Lys  Phe Pro Leu Tyr Met  Ile Gly His Gly Met  Leu Asp Ser 
    1070                 1075                 1080             


Asp Leu  His Leu Ser Ser Lys  Ala Gln Val Phe Glu  His Pro His 
    1085                 1090                 1095             


Ile Gln  Asp Ala Ala Ser Gln  Leu Pro Asp Asp Glu  Ser Leu Phe 
    1100                 1105                 1110             


Phe Gly  Asp Thr Gly Leu Ser  Lys Asn Pro Ile Glu  Leu Val Glu 
    1115                 1120                 1125             


Gly Trp  Phe Ser Ser Trp Lys  Ser Ser Ile Ala Ser  Phe Phe Phe 
    1130                 1135                 1140             


Ile Ile  Gly Leu Ile Ile Gly  Leu Phe Leu Val Leu  Arg Val Gly 
    1145                 1150                 1155             


Ile His  Leu Cys Ile Lys Leu  Lys His Thr Lys Lys  Arg Gln Ile 
    1160                 1165                 1170             


Tyr Thr  Asp Ile Glu Met Asn  Arg Leu Gly Lys 
    1175                 1180                 


<210>  39
<211>  730
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 S-protein signal peptide with S-protein receptor 
       binding domain with full length VSVG without VSVG signal peptide

<400>  39

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Arg Val Gln Pro 
1               5                   10                  15      


Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe 
            20                  25                  30          


Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn 
        35                  40                  45              


Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn 
    50                  55                  60                  


Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
65                  70                  75                  80  


Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile 
                85                  90                  95      


Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile 
            100                 105                 110         


Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile 
        115                 120                 125             


Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn 
    130                 135                 140                 


Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg 
145                 150                 155                 160 


Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly 
                165                 170                 175     


Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln 
            180                 185                 190         


Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser 
        195                 200                 205             


Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser 
    210                 215                 220                 


Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Lys Phe Thr Ile Val 
225                 230                 235                 240 


Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr 
                245                 250                 255     


His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp His Asn Asp Leu Ile 
            260                 265                 270         


Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser His Lys Ala Ile Gln 
        275                 280                 285             


Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val Thr Thr Cys Asp 
    290                 295                 300                 


Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser Ile Arg Ser Phe 
305                 310                 315                 320 


Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln 
                325                 330                 335     


Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala 
            340                 345                 350         


Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val Thr Pro His His 
        355                 360                 365             


Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp Ser Gln Phe Ile 
    370                 375                 380                 


Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val His Asn Ser Thr 
385                 390                 395                 400 


Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys Asp Ser Asn Leu 
                405                 410                 415     


Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp Gly Glu Leu Ser Ser 
            420                 425                 430         


Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn Tyr Phe Ala Tyr Glu 
        435                 440                 445             


Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys Lys His Trp Gly Val 
    450                 455                 460                 


Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala Asp Lys Asp Leu Phe 
465                 470                 475                 480 


Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly Ser Ser Ile Ser Ala 
                485                 490                 495     


Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile Gln Asp Val Glu Arg 
            500                 505                 510         


Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp Ser Lys Ile Arg Ala 
        515                 520                 525             


Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn 
    530                 535                 540                 


Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr 
545                 550                 555                 560 


Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala Ala Pro Ile Leu Ser 
                565                 570                 575     


Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp 
            580                 585                 590         


Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile Gly Pro Asn Gly Val 
        595                 600                 605             


Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu Tyr Met Ile Gly His 
    610                 615                 620                 


Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys Ala Gln Val Phe 
625                 630                 635                 640 


Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu 
                645                 650                 655     


Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu 
            660                 665                 670         


Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe 
        675                 680                 685             


Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val Leu Arg Val Gly 
    690                 695                 700                 


Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys Arg Gln Ile Tyr 
705                 710                 715                 720 


Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                725                 730 


<210>  40
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG derivative signal peptide with S-protein receptor binding 
       domain with full length VSVG without VSVG signal peptide

<400>  40

Met Phe Met Pro Ser Ser Leu Ser Tyr Ser Ser Trp Ala Thr Cys Trp 
1               5                   10                  15      


Leu Leu Cys Cys Leu Ile Ile Leu Ala Lys Asn Ser Ser Thr Asp Pro 
            20                  25                  30          


Ser Arg Asn Ser Asp Thr Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu 
        35                  40                  45              


Phe Ile Gly Val Asn Cys Arg Val Gln Pro Thr Glu Ser Ile Val Arg 
    50                  55                  60                  


Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
65                  70                  75                  80  


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
                85                  90                  95      


Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr 
            100                 105                 110         


Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe 
        115                 120                 125             


Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg 
    130                 135                 140                 


Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys 
145                 150                 155                 160 


Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn 
                165                 170                 175     


Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe 
            180                 185                 190         


Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile 
        195                 200                 205             


Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys 
    210                 215                 220                 


Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly 
225                 230                 235                 240 


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala 
                245                 250                 255     


Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn 
            260                 265                 270         


Lys Cys Val Asn Phe Lys Phe Thr Ile Val Phe Pro His Asn Gln Lys 
        275                 280                 285             


Gly Asn Trp Lys Asn Val Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser 
    290                 295                 300                 


Ser Asp Leu Asn Trp His Asn Asp Leu Ile Gly Thr Ala Leu Gln Val 
305                 310                 315                 320 


Lys Met Pro Lys Ser His Lys Ala Ile Gln Ala Asp Gly Trp Met Cys 
                325                 330                 335     


His Ala Ser Lys Trp Val Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro 
            340                 345                 350         


Lys Tyr Ile Thr His Ser Ile Arg Ser Phe Thr Pro Ser Val Glu Gln 
        355                 360                 365             


Cys Lys Glu Ser Ile Glu Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro 
    370                 375                 380                 


Gly Phe Pro Pro Gln Ser Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu 
385                 390                 395                 400 


Ala Val Ile Val Gln Val Thr Pro His His Val Leu Val Asp Glu Tyr 
                405                 410                 415     


Thr Gly Glu Trp Val Asp Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn 
            420                 425                 430         


Tyr Ile Cys Pro Thr Val His Asn Ser Thr Thr Trp His Ser Asp Tyr 
        435                 440                 445             


Lys Val Lys Gly Leu Cys Asp Ser Asn Leu Ile Ser Met Asp Ile Thr 
    450                 455                 460                 


Phe Phe Ser Glu Asp Gly Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr 
465                 470                 475                 480 


Gly Phe Arg Ser Asn Tyr Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys 
                485                 490                 495     


Lys Met Gln Tyr Cys Lys His Trp Gly Val Arg Leu Pro Ser Gly Val 
            500                 505                 510         


Trp Phe Glu Met Ala Asp Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro 
        515                 520                 525             


Glu Cys Pro Glu Gly Ser Ser Ile Ser Ala Pro Ser Gln Thr Ser Val 
    530                 535                 540                 


Asp Val Ser Leu Ile Gln Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu 
545                 550                 555                 560 


Cys Gln Glu Thr Trp Ser Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro 
                565                 570                 575     


Val Asp Leu Ser Tyr Leu Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala 
            580                 585                 590         


Phe Thr Ile Ile Asn Gly Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile 
        595                 600                 605             


Arg Val Asp Ile Ala Ala Pro Ile Leu Ser Arg Met Val Gly Met Ile 
    610                 615                 620                 


Ser Gly Thr Thr Thr Glu Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr 
625                 630                 635                 640 


Glu Asp Val Glu Ile Gly Pro Asn Gly Val Leu Arg Thr Ser Ser Gly 
                645                 650                 655     


Tyr Lys Phe Pro Leu Tyr Met Ile Gly His Gly Met Leu Asp Ser Asp 
            660                 665                 670         


Leu His Leu Ser Ser Lys Ala Gln Val Phe Glu His Pro His Ile Gln 
        675                 680                 685             


Asp Ala Ala Ser Gln Leu Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp 
    690                 695                 700                 


Thr Gly Leu Ser Lys Asn Pro Ile Glu Leu Val Glu Gly Trp Phe Ser 
705                 710                 715                 720 


Ser Trp Lys Ser Ser Ile Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile 
                725                 730                 735     


Ile Gly Leu Phe Leu Val Leu Arg Val Gly Ile His Leu Cys Ile Lys 
            740                 745                 750         


Leu Lys His Thr Lys Lys Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn 
        755                 760                 765             


Arg Leu Gly Lys 
    770         


<210>  41
<211>  734
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VSVG WT signal peptide with S-protein receptor binding domain 
       with full length VSVG without VSVG signal peptitde

<400>  41

Met Lys Cys Leu Leu Tyr Leu Ala Phe Leu Phe Ile Gly Val Asn Cys 
1               5                   10                  15      


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
            20                  25                  30          


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
        35                  40                  45              


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
    50                  55                  60                  


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
65                  70                  75                  80  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
                85                  90                  95      


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
            100                 105                 110         


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
        115                 120                 125             


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
    130                 135                 140                 


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
145                 150                 155                 160 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
                165                 170                 175     


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
            180                 185                 190         


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
        195                 200                 205             


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
    210                 215                 220                 


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Lys 
225                 230                 235                 240 


Phe Thr Ile Val Phe Pro His Asn Gln Lys Gly Asn Trp Lys Asn Val 
                245                 250                 255     


Pro Ser Asn Tyr His Tyr Cys Pro Ser Ser Ser Asp Leu Asn Trp His 
            260                 265                 270         


Asn Asp Leu Ile Gly Thr Ala Leu Gln Val Lys Met Pro Lys Ser His 
        275                 280                 285             


Lys Ala Ile Gln Ala Asp Gly Trp Met Cys His Ala Ser Lys Trp Val 
    290                 295                 300                 


Thr Thr Cys Asp Phe Arg Trp Tyr Gly Pro Lys Tyr Ile Thr His Ser 
305                 310                 315                 320 


Ile Arg Ser Phe Thr Pro Ser Val Glu Gln Cys Lys Glu Ser Ile Glu 
                325                 330                 335     


Gln Thr Lys Gln Gly Thr Trp Leu Asn Pro Gly Phe Pro Pro Gln Ser 
            340                 345                 350         


Cys Gly Tyr Ala Thr Val Thr Asp Ala Glu Ala Val Ile Val Gln Val 
        355                 360                 365             


Thr Pro His His Val Leu Val Asp Glu Tyr Thr Gly Glu Trp Val Asp 
    370                 375                 380                 


Ser Gln Phe Ile Asn Gly Lys Cys Ser Asn Tyr Ile Cys Pro Thr Val 
385                 390                 395                 400 


His Asn Ser Thr Thr Trp His Ser Asp Tyr Lys Val Lys Gly Leu Cys 
                405                 410                 415     


Asp Ser Asn Leu Ile Ser Met Asp Ile Thr Phe Phe Ser Glu Asp Gly 
            420                 425                 430         


Glu Leu Ser Ser Leu Gly Lys Glu Gly Thr Gly Phe Arg Ser Asn Tyr 
        435                 440                 445             


Phe Ala Tyr Glu Thr Gly Gly Lys Ala Cys Lys Met Gln Tyr Cys Lys 
    450                 455                 460                 


His Trp Gly Val Arg Leu Pro Ser Gly Val Trp Phe Glu Met Ala Asp 
465                 470                 475                 480 


Lys Asp Leu Phe Ala Ala Ala Arg Phe Pro Glu Cys Pro Glu Gly Ser 
                485                 490                 495     


Ser Ile Ser Ala Pro Ser Gln Thr Ser Val Asp Val Ser Leu Ile Gln 
            500                 505                 510         


Asp Val Glu Arg Ile Leu Asp Tyr Ser Leu Cys Gln Glu Thr Trp Ser 
        515                 520                 525             


Lys Ile Arg Ala Gly Leu Pro Ile Ser Pro Val Asp Leu Ser Tyr Leu 
    530                 535                 540                 


Ala Pro Lys Asn Pro Gly Thr Gly Pro Ala Phe Thr Ile Ile Asn Gly 
545                 550                 555                 560 


Thr Leu Lys Tyr Phe Glu Thr Arg Tyr Ile Arg Val Asp Ile Ala Ala 
                565                 570                 575     


Pro Ile Leu Ser Arg Met Val Gly Met Ile Ser Gly Thr Thr Thr Glu 
            580                 585                 590         


Arg Glu Leu Trp Asp Asp Trp Ala Pro Tyr Glu Asp Val Glu Ile Gly 
        595                 600                 605             


Pro Asn Gly Val Leu Arg Thr Ser Ser Gly Tyr Lys Phe Pro Leu Tyr 
    610                 615                 620                 


Met Ile Gly His Gly Met Leu Asp Ser Asp Leu His Leu Ser Ser Lys 
625                 630                 635                 640 


Ala Gln Val Phe Glu His Pro His Ile Gln Asp Ala Ala Ser Gln Leu 
                645                 650                 655     


Pro Asp Asp Glu Ser Leu Phe Phe Gly Asp Thr Gly Leu Ser Lys Asn 
            660                 665                 670         


Pro Ile Glu Leu Val Glu Gly Trp Phe Ser Ser Trp Lys Ser Ser Ile 
        675                 680                 685             


Ala Ser Phe Phe Phe Ile Ile Gly Leu Ile Ile Gly Leu Phe Leu Val 
    690                 695                 700                 


Leu Arg Val Gly Ile His Leu Cys Ile Lys Leu Lys His Thr Lys Lys 
705                 710                 715                 720 


Arg Gln Ile Tyr Thr Asp Ile Glu Met Asn Arg Leu Gly Lys 
                725                 730                 


<210>  42
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP3 gene siRNA sense strand

<400>  42
guacauguca gcauuaaauc acacu                                             25


<210>  43
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP3 gene siRNA antisense strand

<400>  43
agugugauuu aaugcugaca uguaccu                                           27


<210>  44
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP3 gene siRNA sense strand

<400>  44
augguacauu uacuugugcu aguga                                             25


<210>  45
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP3 gene siRNA antisense strand

<400>  45
ucacuagcac aaguaaaugu accaugc                                           27


<210>  46
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP3 gene siRNA sense strand

<400>  46
ggagcuaaau uguuacauaa accua                                             25


<210>  47
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP3 gene siRNA antisense strand

<400>  47
uagguuuaug uaacaauuua gcuccuu                                           27


<210>  48
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP7 gene siRNA sense strand

<400>  48
gacauucucu uagcuaaaga uacua                                             25


<210>  49
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP7 gene siRNA antisense strand

<400>  49
uaguaucuuu agcuaagaga augucau                                           27


<210>  50
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP7 gene siRNA sense strand

<400>  50
cuaaagauac uacugaagcc uuuga                                             25


<210>  51
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 NSP7 gene siRNA antisense strand

<400>  51
ucaaaggcuu caguaguauc uuuagcu                                           27


<210>  52
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA sense strand

<400>  52
uacuaugacc aauagacagu uucau                                             25


<210>  53
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA antisense strand

<400>  53
augaaacugu cuauugguca uaguacu                                           27


<210>  54
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA sense strand

<400>  54
agaggagcua cuguaguaau uggaa                                             25


<210>  55
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA antisense strand

<400>  55
uuccaauuac uacaguagcu ccucuag                                           27


<210>  56
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA sense strand

<400>  56
gcuacuguag uaauuggaac aagca                                             25


<210>  57
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA antisense strand

<400>  57
ugcuuguucc aauuacuaca guagcuc                                           27


<210>  58
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA sense strand

<400>  58
aguauugagu gaaaugguca ugugu                                             25


<210>  59
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 RdRp gene siRNA antisense strand

<400>  59
acacaugacc auuucacuca auacuug                                           27


<210>  60
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 E gene siRNA sense strand

<400>  60
agucuuguaa aaccuucuuu uuacg                                             25


<210>  61
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 E gene siRNA antisense strand

<400>  61
cguaaaaaga agguuuuaca agacuca                                           27


<210>  62
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 M gene siRNA sense strand

<400>  62
guuuacagaa uaaauuggau caccg                                             25


<210>  63
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 M gene siRNA antisense strand

<400>  63
cggugaucca auuuauucug uaaacag                                           27


<210>  64
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 M gene siRNA sense strand

<400>  64
guacuauuac cguugaagag cuuaa                                             25


<210>  65
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 M gene siRNA antisense strand

<400>  65
uuaagcucuu caacgguaau aguaccg                                           27


<210>  66
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N gene siRNA sense strand

<400>  66
aguccaagau gguauuucua cuacc                                             25


<210>  67
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N gene siRNA antisense strand

<400>  67
gguaguagaa auaccaucuu ggacuga                                           27


<210>  68
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N gene siRNA sense strand

<400>  68
ggccaaacug ucacuaagaa aucug                                             25


<210>  69
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N gene siRNA antisense strand

<400>  69
cagauuucuu agugacaguu uggccuu                                           27


<210>  70
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N gene siRNA sense strand

<400>  70
aacauggcaa ggaagaccuu aaauu                                             25


<210>  71
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 N gene siRNA antisense strand

<400>  71
aauuuaaggu cuuccuugcc auguuga                                           27


<210>  72
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Orf7a gene siRNA sense strand

<400>  72
acuugugagc uuuaucacua ccaag                                             25


<210>  73
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Orf7a gene siRNA antisense strand

<400>  73
cuugguagug auaaagcuca caaguag                                           27


<210>  74
<211>  25
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Orf7a gene siRNA sense strand

<400>  74
ccagaucagu uucaccuaaa cuguu                                             25


<210>  75
<211>  27
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Orf7a gene siRNA antisense strand

<400>  75
aacaguuuag gugaaacuga ucuggca                                           27


