                         SEQUENCE LISTING

<110>  Monash University
 
<120>  Novel inhibin variants

<130>  53130156AZD

<150>  AU2020901684
<151>  2020-05-25

<160>  24    

<170>  PatentIn version 3.5

<210>  1
<211>  366
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Val Leu His Leu Leu Leu Phe Leu Leu Leu Thr Pro Gln Gly Gly 
1               5                   10                  15      


His Ser Cys Gln Gly Leu Glu Leu Ala Arg Glu Leu Val Leu Ala Lys 
            20                  25                  30          


Val Arg Ala Leu Phe Leu Asp Ala Leu Gly Pro Pro Ala Val Thr Arg 
        35                  40                  45              


Glu Gly Gly Asp Pro Gly Val Arg Arg Leu Pro Arg Arg His Ala Leu 
    50                  55                  60                  


Gly Gly Phe Thr His Arg Gly Ser Glu Pro Glu Glu Glu Glu Asp Val 
65                  70                  75                  80  


Ser Gln Ala Ile Leu Phe Pro Ala Thr Asp Ala Ser Cys Glu Asp Lys 
                85                  90                  95      


Ser Ala Ala Arg Gly Leu Ala Gln Glu Ala Glu Glu Gly Leu Phe Arg 
            100                 105                 110         


Tyr Met Phe Arg Pro Ser Gln His Thr Arg Ser Arg Gln Val Thr Ser 
        115                 120                 125             


Ala Gln Leu Trp Phe His Thr Gly Leu Asp Arg Gln Gly Thr Ala Ala 
    130                 135                 140                 


Ser Asn Ser Ser Glu Pro Leu Leu Gly Leu Leu Ala Leu Ser Pro Gly 
145                 150                 155                 160 


Gly Pro Val Ala Val Pro Met Ser Leu Gly His Ala Pro Pro His Trp 
                165                 170                 175     


Ala Val Leu His Leu Ala Thr Ser Ala Leu Ser Leu Leu Thr His Pro 
            180                 185                 190         


Val Leu Val Leu Leu Leu Arg Cys Pro Leu Cys Thr Cys Ser Ala Arg 
        195                 200                 205             


Pro Glu Ala Thr Pro Phe Leu Val Ala His Thr Arg Thr Arg Pro Pro 
    210                 215                 220                 


Ser Gly Gly Glu Arg Ala Arg Arg Ser Thr Pro Leu Met Ser Trp Pro 
225                 230                 235                 240 


Trp Ser Pro Ser Ala Leu Arg Leu Leu Gln Arg Pro Pro Glu Glu Pro 
                245                 250                 255     


Ala Ala His Ala Asn Cys His Arg Val Ala Leu Asn Ile Ser Phe Gln 
            260                 265                 270         


Glu Leu Gly Trp Glu Arg Trp Ile Val Tyr Pro Pro Ser Phe Ile Phe 
        275                 280                 285             


His Tyr Cys His Gly Gly Cys Gly Leu His Ile Pro Pro Asn Leu Ser 
    290                 295                 300                 


Leu Pro Val Pro Gly Ala Pro Pro Thr Pro Ala Gln Pro Tyr Ser Leu 
305                 310                 315                 320 


Leu Pro Gly Ala Gln Pro Cys Cys Ala Ala Leu Pro Gly Thr Met Arg 
                325                 330                 335     


Pro Leu His Val Arg Thr Thr Ser Asp Gly Gly Tyr Ser Phe Lys Tyr 
            340                 345                 350         


Glu Thr Val Pro Asn Leu Leu Thr Gln His Cys Ala Cys Ile 
        355                 360                 365     


<210>  2
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  2

Cys Gln Gly Leu Glu Leu Ala Arg Glu Leu Val Leu Ala Lys Val Arg 
1               5                   10                  15      


Ala Leu Phe Leu Asp Ala Leu Gly Pro Pro Ala Val Thr Arg Glu Gly 
            20                  25                  30          


Gly Asp Pro Gly Val Arg Arg Leu Pro Arg Arg His Ala Leu Gly Gly 
        35                  40                  45              


Phe Thr His Arg Gly Ser Glu Pro Glu Glu Glu Glu Asp Val Ser Gln 
    50                  55                  60                  


Ala Ile Leu Phe Pro Ala Thr Asp Ala Ser Cys Glu Asp Lys Ser Ala 
65                  70                  75                  80  


Ala Arg Gly Leu Ala Gln Glu Ala Glu Glu Gly Leu Phe Arg Tyr Met 
                85                  90                  95      


Phe Arg Pro Ser Gln His Thr Arg Ser Arg Gln Val Thr Ser Ala Gln 
            100                 105                 110         


Leu Trp Phe His Thr Gly Leu Asp Arg Gln Gly Thr Ala Ala Ser Asn 
        115                 120                 125             


Ser Ser Glu Pro Leu Leu Gly Leu Leu Ala Leu Ser Pro Gly Gly Pro 
    130                 135                 140                 


Val Ala Val Pro Met Ser Leu Gly His Ala Pro Pro His Trp Ala Val 
145                 150                 155                 160 


Leu His Leu Ala Thr Ser Ala Leu Ser Leu Leu Thr His Pro Val Leu 
                165                 170                 175     


Val Leu Leu Leu Arg Cys Pro Leu Cys Thr Cys Ser Ala Arg Pro Glu 
            180                 185                 190         


Ala Thr Pro Phe Leu Val Ala His Thr Arg Thr Arg Pro Pro Ser Gly 
        195                 200                 205             


Gly Glu Arg Ala Arg Arg 
    210                 


<210>  3
<211>  134
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Thr Pro Leu Met Ser Trp Pro Trp Ser Pro Ser Ala Leu Arg Leu 
1               5                   10                  15      


Leu Gln Arg Pro Pro Glu Glu Pro Ala Ala His Ala Asn Cys His Arg 
            20                  25                  30          


Val Ala Leu Asn Ile Ser Phe Gln Glu Leu Gly Trp Glu Arg Trp Ile 
        35                  40                  45              


Val Tyr Pro Pro Ser Phe Ile Phe His Tyr Cys His Gly Gly Cys Gly 
    50                  55                  60                  


Leu His Ile Pro Pro Asn Leu Ser Leu Pro Val Pro Gly Ala Pro Pro 
65                  70                  75                  80  


Thr Pro Ala Gln Pro Tyr Ser Leu Leu Pro Gly Ala Gln Pro Cys Cys 
                85                  90                  95      


Ala Ala Leu Pro Gly Thr Met Arg Pro Leu His Val Arg Thr Thr Ser 
            100                 105                 110         


Asp Gly Gly Tyr Ser Phe Lys Tyr Glu Thr Val Pro Asn Leu Leu Thr 
        115                 120                 125             


Gln His Cys Ala Cys Ile 
    130                 


<210>  4
<211>  426
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Leu Leu Trp Leu Arg Gly Phe Leu Leu Ala Ser Cys Trp Ile 
1               5                   10                  15      


Ile Val Arg Ser Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala 
            20                  25                  30          


Pro Asp Cys Pro Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro 
        35                  40                  45              


Asn Ser Gln Pro Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn 
    50                  55                  60                  


Met Leu His Leu Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys 
65                  70                  75                  80  


Ala Ala Leu Leu Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly 
                85                  90                  95      


Glu Asn Gly Tyr Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu 
            100                 105                 110         


Met Asn Glu Leu Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu 
        115                 120                 125             


Ser Gly Thr Ala Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly 
    130                 135                 140                 


Ser Asp Leu Ser Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys 
145                 150                 155                 160 


Val Pro Lys Ala Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe 
                165                 170                 175     


Gln Gln Gln Lys His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala 
            180                 185                 190         


Glu Glu Val Gly Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu 
        195                 200                 205             


Lys Val Val Asp Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser 
    210                 215                 220                 


Ser Ser Ile Gln Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val 
225                 230                 235                 240 


Arg Ile Ala Cys Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu 
                245                 250                 255     


Leu Gly Lys Lys Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys 
            260                 265                 270         


Gly Gly Gly Glu Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser 
        275                 280                 285             


His Arg Pro Phe Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro 
    290                 295                 300                 


His Arg Arg Arg Arg Arg Gly Leu Glu Cys Asp Gly Lys Val Asn Ile 
305                 310                 315                 320 


Cys Cys Lys Lys Gln Phe Phe Val Ser Phe Lys Asp Ile Gly Trp Asn 
                325                 330                 335     


Asp Trp Ile Ile Ala Pro Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly 
            340                 345                 350         


Glu Cys Pro Ser His Ile Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe 
        355                 360                 365             


His Ser Thr Val Ile Asn His Tyr Arg Met Arg Gly His Ser Pro Phe 
    370                 375                 380                 


Ala Asn Leu Lys Ser Cys Cys Val Pro Thr Lys Leu Arg Pro Met Ser 
385                 390                 395                 400 


Met Leu Tyr Tyr Asp Asp Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln 
                405                 410                 415     


Asn Met Ile Val Glu Glu Cys Gly Cys Ser 
            420                 425     


<210>  5
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  5

Ser Pro Thr Pro Gly Ser Glu Gly His Ser Ala Ala Pro Asp Cys Pro 
1               5                   10                  15      


Ser Cys Ala Leu Ala Ala Leu Pro Lys Asp Val Pro Asn Ser Gln Pro 
            20                  25                  30          


Glu Met Val Glu Ala Val Lys Lys His Ile Leu Asn Met Leu His Leu 
        35                  40                  45              


Lys Lys Arg Pro Asp Val Thr Gln Pro Val Pro Lys Ala Ala Leu Leu 
    50                  55                  60                  


Asn Ala Ile Arg Lys Leu His Val Gly Lys Val Gly Glu Asn Gly Tyr 
65                  70                  75                  80  


Val Glu Ile Glu Asp Asp Ile Gly Arg Arg Ala Glu Met Asn Glu Leu 
                85                  90                  95      


Met Glu Gln Thr Ser Glu Ile Ile Thr Phe Ala Glu Ser Gly Thr Ala 
            100                 105                 110         


Arg Lys Thr Leu His Phe Glu Ile Ser Lys Glu Gly Ser Asp Leu Ser 
        115                 120                 125             


Val Val Glu Arg Ala Glu Val Trp Leu Phe Leu Lys Val Pro Lys Ala 
    130                 135                 140                 


Asn Arg Thr Arg Thr Lys Val Thr Ile Arg Leu Phe Gln Gln Gln Lys 
145                 150                 155                 160 


His Pro Gln Gly Ser Leu Asp Thr Gly Glu Glu Ala Glu Glu Val Gly 
                165                 170                 175     


Leu Lys Gly Glu Arg Ser Glu Leu Leu Leu Ser Glu Lys Val Val Asp 
            180                 185                 190         


Ala Arg Lys Ser Thr Trp His Val Phe Pro Val Ser Ser Ser Ile Gln 
        195                 200                 205             


Arg Leu Leu Asp Gln Gly Lys Ser Ser Leu Asp Val Arg Ile Ala Cys 
    210                 215                 220                 


Glu Gln Cys Gln Glu Ser Gly Ala Ser Leu Val Leu Leu Gly Lys Lys 
225                 230                 235                 240 


Lys Lys Lys Glu Glu Glu Gly Glu Gly Lys Lys Lys Gly Gly Gly Glu 
                245                 250                 255     


Gly Gly Ala Gly Ala Asp Glu Glu Lys Glu Gln Ser His Arg Pro Phe 
            260                 265                 270         


Leu Met Leu Gln Ala Arg Gln Ser Glu Asp His Pro His Arg Arg Arg 
        275                 280                 285             


Arg Arg 
    290 


<210>  6
<211>  116
<212>  PRT
<213>  Homo sapiens

<400>  6

Gly Leu Glu Cys Asp Gly Lys Val Asn Ile Cys Cys Lys Lys Gln Phe 
1               5                   10                  15      


Phe Val Ser Phe Lys Asp Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro 
            20                  25                  30          


Ser Gly Tyr His Ala Asn Tyr Cys Glu Gly Glu Cys Pro Ser His Ile 
        35                  40                  45              


Ala Gly Thr Ser Gly Ser Ser Leu Ser Phe His Ser Thr Val Ile Asn 
    50                  55                  60                  


His Tyr Arg Met Arg Gly His Ser Pro Phe Ala Asn Leu Lys Ser Cys 
65                  70                  75                  80  


Cys Val Pro Thr Lys Leu Arg Pro Met Ser Met Leu Tyr Tyr Asp Asp 
                85                  90                  95      


Gly Gln Asn Ile Ile Lys Lys Asp Ile Gln Asn Met Ile Val Glu Glu 
            100                 105                 110         


Cys Gly Cys Ser 
        115     


<210>  7
<211>  407
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Gly Leu Pro Gly Arg Ala Leu Gly Ala Ala Cys Leu Leu Leu 
1               5                   10                  15      


Leu Ala Ala Gly Trp Leu Gly Pro Glu Ala Trp Gly Ser Pro Thr Pro 
            20                  25                  30          


Pro Pro Thr Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Gly Ser Pro 
        35                  40                  45              


Gly Gly Ser Gln Asp Thr Cys Thr Ser Cys Gly Gly Phe Arg Arg Pro 
    50                  55                  60                  


Glu Glu Leu Gly Arg Val Asp Gly Asp Phe Leu Glu Ala Val Lys Arg 
65                  70                  75                  80  


His Ile Leu Ser Arg Leu Gln Met Arg Gly Arg Pro Asn Ile Thr His 
                85                  90                  95      


Ala Val Pro Lys Ala Ala Met Val Thr Ala Leu Arg Lys Leu His Ala 
            100                 105                 110         


Gly Lys Val Arg Glu Asp Gly Arg Val Glu Ile Pro His Leu Asp Gly 
        115                 120                 125             


His Ala Ser Pro Gly Ala Asp Gly Gln Glu Arg Val Ser Glu Ile Ile 
    130                 135                 140                 


Ser Phe Ala Glu Thr Asp Gly Leu Ala Ser Ser Arg Val Arg Leu Tyr 
145                 150                 155                 160 


Phe Phe Ile Ser Asn Glu Gly Asn Gln Asn Leu Phe Val Val Gln Ala 
                165                 170                 175     


Ser Leu Trp Leu Tyr Leu Lys Leu Leu Pro Tyr Val Leu Glu Lys Gly 
            180                 185                 190         


Ser Arg Arg Lys Val Arg Val Lys Val Tyr Phe Gln Glu Gln Gly His 
        195                 200                 205             


Gly Asp Arg Trp Asn Met Val Glu Lys Arg Val Asp Leu Lys Arg Ser 
    210                 215                 220                 


Gly Trp His Thr Phe Pro Leu Thr Glu Ala Ile Gln Ala Leu Phe Glu 
225                 230                 235                 240 


Arg Gly Glu Arg Arg Leu Asn Leu Asp Val Gln Cys Asp Ser Cys Gln 
                245                 250                 255     


Glu Leu Ala Val Val Pro Val Phe Val Asp Pro Gly Glu Glu Ser His 
            260                 265                 270         


Arg Pro Phe Val Val Val Gln Ala Arg Leu Gly Asp Ser Arg His Arg 
        275                 280                 285             


Ile Arg Lys Arg Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys 
    290                 295                 300                 


Arg Gln Gln Phe Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp 
305                 310                 315                 320 


Ile Ile Ala Pro Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys 
                325                 330                 335     


Pro Ala Tyr Leu Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr 
            340                 345                 350         


Ala Val Val Asn Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val 
        355                 360                 365             


Asn Ser Cys Cys Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr 
    370                 375                 380                 


Phe Asp Asp Glu Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile 
385                 390                 395                 400 


Val Glu Glu Cys Gly Cys Ala 
                405         


<210>  8
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Pro Thr Pro Pro Pro Thr Pro Ala Ala Pro Pro Pro Pro Pro Pro 
1               5                   10                  15      


Pro Gly Ser Pro Gly Gly Ser Gln Asp Thr Cys Thr Ser Cys Gly Gly 
            20                  25                  30          


Phe Arg Arg Pro Glu Glu Leu Gly Arg Val Asp Gly Asp Phe Leu Glu 
        35                  40                  45              


Ala Val Lys Arg His Ile Leu Ser Arg Leu Gln Met Arg Gly Arg Pro 
    50                  55                  60                  


Asn Ile Thr His Ala Val Pro Lys Ala Ala Met Val Thr Ala Leu Arg 
65                  70                  75                  80  


Lys Leu His Ala Gly Lys Val Arg Glu Asp Gly Arg Val Glu Ile Pro 
                85                  90                  95      


His Leu Asp Gly His Ala Ser Pro Gly Ala Asp Gly Gln Glu Arg Val 
            100                 105                 110         


Ser Glu Ile Ile Ser Phe Ala Glu Thr Asp Gly Leu Ala Ser Ser Arg 
        115                 120                 125             


Val Arg Leu Tyr Phe Phe Ile Ser Asn Glu Gly Asn Gln Asn Leu Phe 
    130                 135                 140                 


Val Val Gln Ala Ser Leu Trp Leu Tyr Leu Lys Leu Leu Pro Tyr Val 
145                 150                 155                 160 


Leu Glu Lys Gly Ser Arg Arg Lys Val Arg Val Lys Val Tyr Phe Gln 
                165                 170                 175     


Glu Gln Gly His Gly Asp Arg Trp Asn Met Val Glu Lys Arg Val Asp 
            180                 185                 190         


Leu Lys Arg Ser Gly Trp His Thr Phe Pro Leu Thr Glu Ala Ile Gln 
        195                 200                 205             


Ala Leu Phe Glu Arg Gly Glu Arg Arg Leu Asn Leu Asp Val Gln Cys 
    210                 215                 220                 


Asp Ser Cys Gln Glu Leu Ala Val Val Pro Val Phe Val Asp Pro Gly 
225                 230                 235                 240 


Glu Glu Ser His Arg Pro Phe Val Val Val Gln Ala Arg Leu Gly Asp 
                245                 250                 255     


Ser Arg His Arg Ile Arg Lys Arg 
            260                 


<210>  9
<211>  115
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Leu Glu Cys Asp Gly Arg Thr Asn Leu Cys Cys Arg Gln Gln Phe 
1               5                   10                  15      


Phe Ile Asp Phe Arg Leu Ile Gly Trp Asn Asp Trp Ile Ile Ala Pro 
            20                  25                  30          


Thr Gly Tyr Tyr Gly Asn Tyr Cys Glu Gly Ser Cys Pro Ala Tyr Leu 
        35                  40                  45              


Ala Gly Val Pro Gly Ser Ala Ser Ser Phe His Thr Ala Val Val Asn 
    50                  55                  60                  


Gln Tyr Arg Met Arg Gly Leu Asn Pro Gly Thr Val Asn Ser Cys Cys 
65                  70                  75                  80  


Ile Pro Thr Lys Leu Ser Thr Met Ser Met Leu Tyr Phe Asp Asp Glu 
                85                  90                  95      


Tyr Asn Ile Val Lys Arg Asp Val Pro Asn Met Ile Val Glu Glu Cys 
            100                 105                 110         


Gly Cys Ala 
        115 


<210>  10
<211>  1098
<212>  DNA
<213>  Homo sapiens

<400>  10
atggtgctgc acctactgct cttcttgctg ctgaccccac agggtgggca cagctgccag       60

gggctggagc tggcccggga acttgttctg gccaaggtga gggccctgtt cttggatgcc      120

ttggggcccc ccgcggtgac cagggaaggt ggggaccctg gagtcaggcg gctgccccga      180

agacatgccc tggggggctt cacacacagg ggctctgagc ccgaggaaga ggaggatgtc      240

tcccaagcca tccttttccc agccacagat gccagctgtg aggacaagtc agctgccaga      300

gggctggccc aggaggctga ggagggcctc ttcagataca tgttccggcc atcccagcat      360

acacgcagcc gccaggtgac ttcagcccag ctgtggttcc acaccgggct ggacaggcag      420

ggcacagcag cctccaatag ctctgagccc ctgctaggcc tgctggcact gtcaccggga      480

ggacccgtgg ctgtgcccat gtctttgggc catgctcccc ctcactgggc cgtgctgcac      540

ctggccacct ctgctctctc tctgctgacc caccccgtcc tggtgctgct gctgcgctgt      600

cccctctgta cctgctcagc ccggcctgag gccacgccct tcctggtggc ccacactcgg      660

accagaccac ccagtggagg ggagagagcc cgacgctcaa ctcccctgat gtcctggcct      720

tggtctccct ctgctctgcg cctgctgcag aggcctccgg aggaaccggc tgcccatgcc      780

aactgccaca gagtagcact gaacatctcc ttccaggagc tgggctggga acggtggatc      840

gtgtaccctc ccagtttcat cttccactac tgtcatggtg gttgtgggct gcacatccca      900

ccaaacctgt cccttccagt ccctggggct ccccctaccc cagcccagcc ctactccttg      960

ctgccagggg cccagccctg ctgtgctgct ctcccaggga ccatgaggcc cctacatgtc     1020

cgcaccacct cggatggagg ttactctttc aagtatgaga cagtgcccaa ccttctcacg     1080

cagcactgtg cttgtatc                                                   1098


<210>  11
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  11
tgccaggggc tggagctggc ccgggaactt gttctggcca aggtgagggc cctgttcttg       60

gatgccttgg ggccccccgc ggtgaccagg gaaggtgggg accctggagt caggcggctg      120

ccccgaagac atgccctggg gggcttcaca cacaggggct ctgagcccga ggaagaggag      180

gatgtctccc aagccatcct tttcccagcc acagatgcca gctgtgagga caagtcagct      240

gccagagggc tggcccagga ggctgaggag ggcctcttca gatacatgtt ccggccatcc      300

cagcatacac gcagccgcca ggtgacttca gcccagctgt ggttccacac cgggctggac      360

aggcagggca cagcagcctc caatagctct gagcccctgc taggcctgct ggcactgtca      420

ccgggaggac ccgtggctgt gcccatgtct ttgggccatg ctccccctca ctgggccgtg      480

ctgcacctgg ccacctctgc tctctctctg ctgacccacc ccgtcctggt gctgctgctg      540

cgctgtcccc tctgtacctg ctcagcccgg cctgaggcca cgcccttcct ggtggcccac      600

actcggacca gaccacccag tggaggggag agagcccgac gc                         642


<210>  12
<211>  402
<212>  DNA
<213>  Homo sapiens

<400>  12
tcaactcccc tgatgtcctg gccttggtct ccctctgctc tgcgcctgct gcagaggcct       60

ccggaggaac cggctgccca tgccaactgc cacagagtag cactgaacat ctccttccag      120

gagctgggct gggaacggtg gatcgtgtac cctcccagtt tcatcttcca ctactgtcat      180

ggtggttgtg ggctgcacat cccaccaaac ctgtcccttc cagtccctgg ggctccccct      240

accccagccc agccctactc cttgctgcca ggggcccagc cctgctgtgc tgctctccca      300

gggaccatga ggcccctaca tgtccgcacc acctcggatg gaggttactc tttcaagtat      360

gagacagtgc ccaaccttct cacgcagcac tgtgcttgta tc                         402


<210>  13
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  13
atgcccttgc tttggctgag aggatttctg ttggcaagtt gctggattat agtgaggagt       60

tcccccaccc caggatccga ggggcacagc gcggcccccg actgtccgtc ctgtgcgctg      120

gccgccctcc caaaggatgt acccaactct cagccagaga tggtggaggc cgtcaagaag      180

cacattttaa acatgctgca cttgaagaag agacccgatg tcacccagcc ggtacccaag      240

gcggcgcttc tgaacgcgat cagaaagctt catgtgggca aagtcgggga gaacgggtat      300

gtggagatag aggatgacat tggaaggagg gcagaaatga atgaacttat ggagcagacc      360

tcggagatca tcacgtttgc cgagtcagga acagccagga agacgctgca cttcgagatt      420

tccaaggaag gcagtgacct gtcagtggtg gagcgtgcag aagtctggct cttcctaaaa      480

gtccccaagg ccaacaggac caggaccaaa gtcaccatcc gcctcttcca gcagcagaag      540

cacccgcagg gcagcttgga cacaggggaa gaggccgagg aagtgggctt aaagggggag      600

aggagtgaac tgttgctctc tgaaaaagta gtagacgctc ggaagagcac ctggcatgtc      660

ttccctgtct ccagcagcat ccagcggttg ctggaccagg gcaagagctc cctggacgtt      720

cggattgcct gtgagcagtg ccaggagagt ggcgccagct tggttctcct gggcaagaag      780

aagaagaaag aagaggaggg ggaagggaaa aagaagggcg gaggtgaagg tggggcagga      840

gcagatgagg aaaaggagca gtcgcacaga cctttcctca tgctgcaggc ccggcagtct      900

gaagaccacc ctcatcgccg gcgtcggcgg ggcttggagt gtgatggcaa ggtcaacatc      960

tgctgtaaga aacagttctt tgtcagtttc aaggacatcg gctggaatga ctggatcatt     1020

gctccctctg gctatcatgc caactactgc gagggtgagt gcccgagcca tatagcaggc     1080

acgtccgggt cctcactgtc cttccactca acagtcatca accactaccg catgcggggc     1140

catagcccct ttgccaacct caaatcgtgc tgtgtgccca ccaagctgag acccatgtcc     1200

atgttgtact atgatgatgg tcaaaacatc atcaaaaagg acattcagaa catgatcgtg     1260

gaggagtgtg ggtgctca                                                   1278


<210>  14
<211>  870
<212>  DNA
<213>  Homo sapiens

<400>  14
tcccccaccc caggatccga ggggcacagc gcggcccccg actgtccgtc ctgtgcgctg       60

gccgccctcc caaaggatgt acccaactct cagccagaga tggtggaggc cgtcaagaag      120

cacattttaa acatgctgca cttgaagaag agacccgatg tcacccagcc ggtacccaag      180

gcggcgcttc tgaacgcgat cagaaagctt catgtgggca aagtcgggga gaacgggtat      240

gtggagatag aggatgacat tggaaggagg gcagaaatga atgaacttat ggagcagacc      300

tcggagatca tcacgtttgc cgagtcagga acagccagga agacgctgca cttcgagatt      360

tccaaggaag gcagtgacct gtcagtggtg gagcgtgcag aagtctggct cttcctaaaa      420

gtccccaagg ccaacaggac caggaccaaa gtcaccatcc gcctcttcca gcagcagaag      480

cacccgcagg gcagcttgga cacaggggaa gaggccgagg aagtgggctt aaagggggag      540

aggagtgaac tgttgctctc tgaaaaagta gtagacgctc ggaagagcac ctggcatgtc      600

ttccctgtct ccagcagcat ccagcggttg ctggaccagg gcaagagctc cctggacgtt      660

cggattgcct gtgagcagtg ccaggagagt ggcgccagct tggttctcct gggcaagaag      720

aagaagaaag aagaggaggg ggaagggaaa aagaagggcg gaggtgaagg tggggcagga      780

gcagatgagg aaaaggagca gtcgcacaga cctttcctca tgctgcaggc ccggcagtct      840

gaagaccacc ctcatcgccg gcgtcggcgg                                       870


<210>  15
<211>  348
<212>  DNA
<213>  Homo sapiens

<400>  15
ggcttggagt gtgatggcaa ggtcaacatc tgctgtaaga aacagttctt tgtcagtttc       60

aaggacatcg gctggaatga ctggatcatt gctccctctg gctatcatgc caactactgc      120

gagggtgagt gcccgagcca tatagcaggc acgtccgggt cctcactgtc cttccactca      180

acagtcatca accactaccg catgcggggc catagcccct ttgccaacct caaatcgtgc      240

tgtgtgccca ccaagctgag acccatgtcc atgttgtact atgatgatgg tcaaaacatc      300

atcaaaaagg acattcagaa catgatcgtg gaggagtgtg ggtgctca                   348


<210>  16
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  16
atggacgggc tgcccggtcg ggcgctgggg gccgcctgcc ttctgctgct ggcggccggc       60

tggctggggc ctgaggcctg gggctcaccc acgcccccgc cgacgcctgc cgcgccgccg      120

ccacccccgc cacccggatc cccgggtggc tcgcaggaca cctgtacgtc gtgcggcggc      180

ttccggcggc cagaggagct cggccgagtg gacggcgact tcctggaggc ggtgaagcgg      240

cacatcttga gccgcctgca gatgcggggc cggcccaaca tcacgcacgc cgtgcctaag      300

gccgccatgg tcacggccct gcgcaagctg cacgcgggca aggtgcgcga ggacggccgc      360

gtggagatcc cgcacctcga cggccacgcc agcccgggcg ccgacggcca ggagcgcgtt      420

tccgaaatca tcagcttcgc cgagacagat ggcctcgcct cctcccgggt ccgcctatac      480

ttcttcatct ccaacgaagg caaccagaac ctgtttgtgg tccaggccag cctgtggctt      540

tacctgaaac tcctgcccta cgtcctggag aagggcagcc ggcggaaggt gcgggtcaaa      600

gtgtacttcc aggagcaggg ccacggtgac aggtggaaca tggtggagaa gagggtggac      660

ctcaagcgca gcggctggca taccttccca ctcacggagg ccatccaggc cttgtttgag      720

cggggcgagc ggcgactcaa cctagacgtg cagtgtgaca gctgccagga gctggccgtg      780

gtgccggtgt tcgtggaccc aggcgaagag tcgcaccggc cctttgtggt ggtgcaggct      840

cggctgggcg acagcaggca ccgcattcgc aagcgaggcc tggagtgcga tggccggacc      900

aacctctgtt gcaggcaaca gttcttcatt gacttccgcc tcatcggctg gaacgactgg      960

atcatagcac ccaccggcta ctacgggaac tactgtgagg gcagctgccc agcctacctg     1020

gcaggggtcc ccggctctgc ctcctccttc cacacggctg tggtgaacca gtaccgcatg     1080

cggggtctga accccggcac ggtgaactcc tgctgcattc ccaccaagct gagcaccatg     1140

tccatgctgt acttcgatga tgagtacaac atcgtcaagc gggacgtgcc caacatgatt     1200

gtggaggagt gcggctgcgc c                                               1221


<210>  17
<211>  792
<212>  DNA
<213>  Homo sapiens

<400>  17
tcacccacgc ccccgccgac gcctgccgcg ccgccgccac ccccgccacc cggatccccg       60

ggtggctcgc aggacacctg tacgtcgtgc ggcggcttcc ggcggccaga ggagctcggc      120

cgagtggacg gcgacttcct ggaggcggtg aagcggcaca tcttgagccg cctgcagatg      180

cggggccggc ccaacatcac gcacgccgtg cctaaggccg ccatggtcac ggccctgcgc      240

aagctgcacg cgggcaaggt gcgcgaggac ggccgcgtgg agatcccgca cctcgacggc      300

cacgccagcc cgggcgccga cggccaggag cgcgtttccg aaatcatcag cttcgccgag      360

acagatggcc tcgcctcctc ccgggtccgc ctatacttct tcatctccaa cgaaggcaac      420

cagaacctgt ttgtggtcca ggccagcctg tggctttacc tgaaactcct gccctacgtc      480

ctggagaagg gcagccggcg gaaggtgcgg gtcaaagtgt acttccagga gcagggccac      540

ggtgacaggt ggaacatggt ggagaagagg gtggacctca agcgcagcgg ctggcatacc      600

ttcccactca cggaggccat ccaggccttg tttgagcggg gcgagcggcg actcaaccta      660

gacgtgcagt gtgacagctg ccaggagctg gccgtggtgc cggtgttcgt ggacccaggc      720

gaagagtcgc accggccctt tgtggtggtg caggctcggc tgggcgacag caggcaccgc      780

attcgcaagc ga                                                          792


<210>  18
<211>  345
<212>  DNA
<213>  Homo sapiens

<400>  18
ggcctggagt gcgatggccg gaccaacctc tgttgcaggc aacagttctt cattgacttc       60

cgcctcatcg gctggaacga ctggatcata gcacccaccg gctactacgg gaactactgt      120

gagggcagct gcccagccta cctggcaggg gtccccggct ctgcctcctc cttccacacg      180

gctgtggtga accagtaccg catgcggggt ctgaaccccg gcacggtgaa ctcctgctgc      240

attcccacca agctgagcac catgtccatg ctgtacttcg atgatgagta caacatcgtc      300

aagcgggacg tgcccaacat gattgtggag gagtgcggct gcgcc                      345


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of FLAG tag

<400>  19

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  20
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of FLAG tag

<400>  20
gactacaaag acgacgacga caaa                                              24


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid of super cut site 1

<400>  21

Ile Ser Ser Arg Lys Lys Arg Ser Val Ser Ser 
1               5                   10      


<210>  22
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of super cut site 1

<400>  22
atctcatcga gaaagaaacg ctcagtctca tcg                                    33


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of His tag

<400>  23

His His His His His His His His His 
1               5                   


<210>  24
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of His tag

<400>  24
catcatcacc atcaccacca tcatcac                                           27


