                               SEQUENCE LISTING

<110> HESS PHARMACEUTICALS, INC.
 
<120> SELENIUM-BASED COMPOSITIONS AND THERAPUTIC METHODS

<130> HESS-1PCT

<140> PCT/US2021/033131
<141> 2021-05-19

<150> 63/027,399
<151> 2020-05-20

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 1
caatggccaa agcactgata gtccgaacct tctgctgctc atccacaaga                  50


<210> 2
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
caatggccaa agcactgata gtccgaactt cctgctgctc atccacaaga                  50


<210> 3
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 3
agcaatggcc aaagcactga                                                   20


<210> 4
<211> 9292
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag       60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga      120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat      180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga      240

cgaaacaccg agcaatggcc aaagcactga gttttagagc tagaaatagc aagttaaaat      300

aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt ttgttttaga      360

gctagaaata gcaagttaaa ataaggctag tccgttttta gcgcgtgcgc caattctgca      420

gacaaatggc tctagaggta cccgttacat aacttacggt aaatggcccg cctggctgac      480

cgcccaacga cccccgccca ttgacgtcaa tagtaacgcc aatagggact ttccattgac      540

gtcaatgggt ggagtattta cggtaaactg cccacttggc agtacatcaa gtgtatcata      600

tgccaagtac gccccctatt gacgtcaatg acggtaaatg gcccgcctgg cattgtgccc      660

agtacatgac cttatgggac tttcctactt ggcagtacat ctacgtatta gtcatcgcta      720

ttaccatggt cgaggtgagc cccacgttct gcttcactct ccccatctcc cccccctccc      780

cacccccaat tttgtattta tttatttttt aattattttg tgcagcgatg ggggcggggg      840

gggggggggg gcgcgcgcca ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc      900

ggagaggtgc ggcggcagcc aatcagagcg gcgcgctccg aaagtttcct tttatggcga      960

ggcggcggcg gcggcggccc tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga     1020

cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga     1080

ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc cttctcctcc gggctgtaat     1140

tagctgagca agaggtaagg gtttaaggga tggttggttg gtggggtatt aatgtttaat     1200

tacctggagc acctgcctga aatcactttt tttcaggttg gaccggtgcc accatggact     1260

ataaggacca cgacggagac tacaaggatc atgatattga ttacaaagac gatgacgata     1320

agatggcccc aaagaagaag cggaaggtcg gtatccacgg agtcccagca gccgacaaga     1380

agtacagcat cggcctggac atcggcacca actctgtggg ctgggccgtg atcaccgacg     1440

agtacaaggt gcccagcaag aaattcaagg tgctgggcaa caccgaccgg cacagcatca     1500

agaagaacct gatcggagcc ctgctgttcg acagcggcga aacagccgag gccacccggc     1560

tgaagagaac cgccagaaga agatacacca gacggaagaa ccggatctgc tatctgcaag     1620

agatcttcag caacgagatg gccaaggtgg acgacagctt cttccacaga ctggaagagt     1680

ccttcctggt ggaagaggat aagaagcacg agcggcaccc catcttcggc aacatcgtgg     1740

acgaggtggc ctaccacgag aagtacccca ccatctacca cctgagaaag aaactggtgg     1800

acagcaccga caaggccgac ctgcggctga tctatctggc cctggcccac atgatcaagt     1860

tccggggcca cttcctgatc gagggcgacc tgaaccccga caacagcgac gtggacaagc     1920

tgttcatcca gctggtgcag acctacaacc agctgttcga ggaaaacccc atcaacgcca     1980

gcggcgtgga cgccaaggcc atcctgtctg ccagactgag caagagcaga cggctggaaa     2040

atctgatcgc ccagctgccc ggcgagaaga agaatggcct gttcggaaac ctgattgccc     2100

tgagcctggg cctgaccccc aacttcaaga gcaacttcga cctggccgag gatgccaaac     2160

tgcagctgag caaggacacc tacgacgacg acctggacaa cctgctggcc cagatcggcg     2220

accagtacgc cgacctgttt ctggccgcca agaacctgtc cgacgccatc ctgctgagcg     2280

acatcctgag agtgaacacc gagatcacca aggcccccct gagcgcctct atgatcaaga     2340

gatacgacga gcaccaccag gacctgaccc tgctgaaagc tctcgtgcgg cagcagctgc     2400

ctgagaagta caaagagatt ttcttcgacc agagcaagaa cggctacgcc ggctacattg     2460

acggcggagc cagccaggaa gagttctaca agttcatcaa gcccatcctg gaaaagatgg     2520

acggcaccga ggaactgctc gtgaagctga acagagagga cctgctgcgg aagcagcgga     2580

ccttcgacaa cggcagcatc ccccaccaga tccacctggg agagctgcac gccattctgc     2640

ggcggcagga agatttttac ccattcctga aggacaaccg ggaaaagatc gagaagatcc     2700

tgaccttccg catcccctac tacgtgggcc ctctggccag gggaaacagc agattcgcct     2760

ggatgaccag aaagagcgag gaaaccatca ccccctggaa cttcgaggaa gtggtggaca     2820

agggcgcttc cgcccagagc ttcatcgagc ggatgaccaa cttcgataag aacctgccca     2880

acgagaaggt gctgcccaag cacagcctgc tgtacgagta cttcaccgtg tataacgagc     2940

tgaccaaagt gaaatacgtg accgagggaa tgagaaagcc cgccttcctg agcggcgagc     3000

agaaaaaggc catcgtggac ctgctgttca agaccaaccg gaaagtgacc gtgaagcagc     3060

tgaaagagga ctacttcaag aaaatcgagt gcttcgactc cgtggaaatc tccggcgtgg     3120

aagatcggtt caacgcctcc ctgggcacat accacgatct gctgaaaatt atcaaggaca     3180

aggacttcct ggacaatgag gaaaacgagg acattctgga agatatcgtg ctgaccctga     3240

cactgtttga ggacagagag atgatcgagg aacggctgaa aacctatgcc cacctgttcg     3300

acgacaaagt gatgaagcag ctgaagcggc ggagatacac cggctggggc aggctgagcc     3360

ggaagctgat caacggcatc cgggacaagc agtccggcaa gacaatcctg gatttcctga     3420

agtccgacgg cttcgccaac agaaacttca tgcagctgat ccacgacgac agcctgacct     3480

ttaaagagga catccagaaa gcccaggtgt ccggccaggg cgatagcctg cacgagcaca     3540

ttgccaatct ggccggcagc cccgccatta agaagggcat cctgcagaca gtgaaggtgg     3600

tggacgagct cgtgaaagtg atgggccggc acaagcccga gaacatcgtg atcgaaatgg     3660

ccagagagaa ccagaccacc cagaagggac agaagaacag ccgcgagaga atgaagcgga     3720

tcgaagaggg catcaaagag ctgggcagcc agatcctgaa agaacacccc gtggaaaaca     3780

cccagctgca gaacgagaag ctgtacctgt actacctgca gaatgggcgg gatatgtacg     3840

tggaccagga actggacatc aaccggctgt ccgactacga tgtggaccat atcgtgcctc     3900

agagctttct gaaggacgac tccatcgaca acaaggtgct gaccagaagc gacaagaacc     3960

ggggcaagag cgacaacgtg ccctccgaag aggtcgtgaa gaagatgaag aactactggc     4020

ggcagctgct gaacgccaag ctgattaccc agagaaagtt cgacaatctg accaaggccg     4080

agagaggcgg cctgagcgaa ctggataagg ccggcttcat caagagacag ctggtggaaa     4140

cccggcagat cacaaagcac gtggcacaga tcctggactc ccggatgaac actaagtacg     4200

acgagaatga caagctgatc cgggaagtga aagtgatcac cctgaagtcc aagctggtgt     4260

ccgatttccg gaaggatttc cagttttaca aagtgcgcga gatcaacaac taccaccacg     4320

cccacgacgc ctacctgaac gccgtcgtgg gaaccgccct gatcaaaaag taccctaagc     4380

tggaaagcga gttcgtgtac ggcgactaca aggtgtacga cgtgcggaag atgatcgcca     4440

agagcgagca ggaaatcggc aaggctaccg ccaagtactt cttctacagc aacatcatga     4500

actttttcaa gaccgagatt accctggcca acggcgagat ccggaagcgg cctctgatcg     4560

agacaaacgg cgaaaccggg gagatcgtgt gggataaggg ccgggatttt gccaccgtgc     4620

ggaaagtgct gagcatgccc caagtgaata tcgtgaaaaa gaccgaggtg cagacaggcg     4680

gcttcagcaa agagtctatc ctgcccaaga ggaacagcga taagctgatc gccagaaaga     4740

aggactggga ccctaagaag tacggcggct tcgacagccc caccgtggcc tattctgtgc     4800

tggtggtggc caaagtggaa aagggcaagt ccaagaaact gaagagtgtg aaagagctgc     4860

tggggatcac catcatggaa agaagcagct tcgagaagaa tcccatcgac tttctggaag     4920

ccaagggcta caaagaagtg aaaaaggacc tgatcatcaa gctgcctaag tactccctgt     4980

tcgagctgga aaacggccgg aagagaatgc tggcctctgc cggcgaactg cagaagggaa     5040

acgaactggc cctgccctcc aaatatgtga acttcctgta cctggccagc cactatgaga     5100

agctgaaggg ctcccccgag gataatgagc agaaacagct gtttgtggaa cagcacaagc     5160

actacctgga cgagatcatc gagcagatca gcgagttctc caagagagtg atcctggccg     5220

acgctaatct ggacaaagtg ctgtccgcct acaacaagca ccgggataag cccatcagag     5280

agcaggccga gaatatcatc cacctgttta ccctgaccaa tctgggagcc cctgccgcct     5340

tcaagtactt tgacaccacc atcgaccgga agaggtacac cagcaccaaa gaggtgctgg     5400

acgccaccct gatccaccag agcatcaccg gcctgtacga gacacggatc gacctgtctc     5460

agctgggagg cgacaaaagg ccggcggcca cgaaaaaggc cggccaggca aaaaagaaaa     5520

aggaattcgg cagtggagag ggcagaggaa gtctgctaac atgcggtgac gtcgaggaga     5580

atcctggccc agtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg     5640

agctggacgg cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg     5700

ccacctacgg caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct     5760

ggcccaccct cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc     5820

acatgaagca gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca     5880

ccatcttctt caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg     5940

acaccctggt gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc     6000

tggggcacaa gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc     6060

agaagaacgg catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc     6120

agctcgccga ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg     6180

acaaccacta cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc     6240

acatggtcct gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt     6300

acaaggaatt ctaactagag ctcgctgatc agcctcgact gtgccttcta gttgccagcc     6360

atctgttgtt tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt     6420

cctttcctaa taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct     6480

ggggggtggg gtggggcagg acagcaaggg ggaggattgg gaagagaata gcaggcatgc     6540

tggggagcgg ccgcaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg     6600

ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc     6660

ctcagtgagc gagcgagcgc gcagctgcct gcaggggcgc ctgatgcggt attttctcct     6720

tacgcatctg tgcggtattt cacaccgcat acgtcaaagc aaccatagta cgcgccctgt     6780

agcggcgcat taagcgcggc gggtgtggtg gttacgcgca gcgtgaccgc tacacttgcc     6840

agcgccctag cgcccgctcc tttcgctttc ttcccttcct ttctcgccac gttcgccggc     6900

tttccccgtc aagctctaaa tcgggggctc cctttagggt tccgatttag tgctttacgg     6960

cacctcgacc ccaaaaaact tgatttgggt gatggttcac gtagtgggcc atcgccctga     7020

tagacggttt ttcgcccttt gacgttggag tccacgttct ttaatagtgg actcttgttc     7080

caaactggaa caacactcaa ccctatctcg ggctattctt ttgatttata agggattttg     7140

ccgatttcgg cctattggtt aaaaaatgag ctgatttaac aaaaatttaa cgcgaatttt     7200

aacaaaatat taacgtttac aattttatgg tgcactctca gtacaatctg ctctgatgcc     7260

gcatagttaa gccagccccg acacccgcca acacccgctg acgcgccctg acgggcttgt     7320

ctgctcccgg catccgctta cagacaagct gtgaccgtct ccgggagctg catgtgtcag     7380

aggttttcac cgtcatcacc gaaacgcgcg agacgaaagg gcctcgtgat acgcctattt     7440

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     7500

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     7560

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     7620

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     7680

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     7740

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     7800

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     7860

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     7920

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     7980

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     8040

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     8100

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     8160

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     8220

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     8280

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtggaag ccgcggtatc     8340

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     8400

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     8460

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     8520

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     8580

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     8640

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     8700

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     8760

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     8820

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     8880

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     8940

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     9000

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     9060

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     9120

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     9180

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     9240

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gt             9292


