                         SEQUENCE LISTING

<110>  REMD Biotherapeutics, Inc.
 
<120>  HUMAN ENDOTHELIN RECEPTOR A (ETRA) ANTAGONIST ANTIBODIES

<130>  CACRE1.0021WO

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 
    130                 135                 140                 


Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 
145                 150                 155                 160 


Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 
                165                 170                 175     


Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Gly Ile Gly Ile Pro Leu Val Thr Ala Ile Glu Ile Val Ser 
        195                 200                 205             


Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 
    210                 215                 220                 


Val Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met 
225                 230                 235                 240 


Leu Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 
                245                 250                 255     


Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 
            260                 265                 270         


Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 
        275                 280                 285             


Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 
    290                 295                 300                 


Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 
305                 310                 315                 320 


Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met 
                325                 330                 335     


Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 
            340                 345                 350         


Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 
        355                 360                 365             


Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 
    370                 375                 380                 


Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 
385                 390                 395                 400 


Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn Asn His Asn 
                405                 410                 415     


Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
            420                 425         


<210>  2
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  2

Ser Tyr Trp Met Asn 
1               5   


<210>  3
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Tyr Tyr Ile His 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  4

Asn Tyr Gly Met Ser 
1               5   


<210>  5
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Ile Tyr Pro Gly Asn Gly Asp Thr Asn Tyr Asn Gly Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  6

Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu Tyr Ala Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  7

Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  8
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  8

Arg Gly Ser Leu Asp Tyr 
1               5       


<210>  9
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  9

Gly Tyr Thr Phe Thr Asn Trp Tyr Ser Asn Ser Tyr 
1               5                   10          


<210>  10
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  10

Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr 
1               5                   10  


<210>  11
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  11

Lys Ser Ser His Ser Leu Val His Ser Asn Gly Asp Thr Tyr Leu His 
1               5                   10                  15      


<210>  12
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  12

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  13
<211>  14
<212>  PRT
<213>  Mus musculus

<400>  13

Arg Ser Ile Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  14
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  14

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  15
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  16

Ser Gln Thr Thr Tyr Val Pro Tyr Thr 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  17

Ser Gln Ser Thr His Val Pro Tyr Thr 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  18

Ala Leu Trp Tyr Ser Asn His Trp Val 
1               5                   


<210>  19
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  19

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Phe Asp Tyr Ala Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Asp Leu Glu Trp Ile 
        35                  40                  45              


Gly Gln Ile Tyr Pro Gly Asn Gly Asp Thr Asn Tyr Asn Gly Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Ser Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Arg Gly Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  20
<211>  345
<212>  DNA
<213>  Mus musculus

<400>  20
caggttcagc tgcagcagtc tggggctgag ttggtgaggc ctgggtcctc agtgaggatt       60

tcctgcaagg cttttgacta tgcattcagt agctactgga tgaactgggt gaagcagagg      120

cctggacagg atcttgagtg gattggacag atttatcctg gaaatggtga tactaactac      180

aatggaaagt tcaggggtaa agcctcactg actgcagaca aatcctccag cacagcctac      240

atgcacctca gcagcctaac atctgaggac tctgcggtct atttctgtgc aagacggggg      300

tctttggact actggggtca aggaacctca gtcaccgtct cctca                      345


<210>  21
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  21

Asp Val Val Met Thr Gln Ile Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ser Ser Ile Ser Cys Lys Ser Ser His Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asp Thr Tyr Leu His Trp Phe Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Thr 
                85                  90                  95      


Thr Tyr Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  22
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  22
gatgtggtga tgacccaaat tccactctcc ctgcctgtca gtcttggaga tcaatcctcc       60

atctcttgca aatctagtca tagccttgta catagtaatg gagacaccta tttacattgg      120

ttcctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtctc caaccgattt      180

tctggggtcc cagacaggtt cactggcagt ggttcaggga cagagttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaactac atatgttccg      300

tacacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  23
<211>  116
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Pro Ala Ser Gly Phe Thr Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Glu Asp Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ser Asn Trp Tyr Ser Asn Ser Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  348
<212>  DNA
<213>  Mus musculus

<400>  24
gaggttcagc tgcagcagtc tggggcagag cttgtgaggc caggggcctc agtcaagttg       60

tcctgcccag cttctggctt caccattaaa gactactata tacactgggt gaagcagagg      120

cctgagcagg gcctggagtg gattggaagg attgatcctg aggatggtga tactgaatat      180

gccccgaagt tccagggcaa ggccactatg actgcagaca catcctccaa cacagcctac      240

ctgcacctca gcagcctgac atctgaggac actgccgtct attactgtac ttcaaactgg      300

tatagtaact cctactgggg ccaaggcacc actctcacag tctcctca                   348


<210>  25
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  25

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Val Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  26
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  26
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaaa agccaggcca gtctccaaag gtcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tatacgttcg gaggggggac caagctggaa ataaaa                                336


<210>  27
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  27

Gln Ile Gln Leu Val Gln Ser Gly Pro Asp Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  28
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  28
cagatccagt tggtacagtc tggacctgac ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cttctgggta taccttcaca aactatggaa tgagctgggt gaaacaggct      120

ccaggaaagg gtttaaagtg gatgggctgg ataaacacct attctggaga gtcaacatat      180

gctgatgact tcaagggacg gtttgccttc tctttggaaa cctctgccag cactgcctat      240

ttgcagatca acaacctcaa aaatgaggac acggctacat atttctgtgc aagatccctc      300

aaccgggaca cctggtttac ttactggggc caagggactc tggtcactgt ctctgca         357


<210>  29
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  29

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Ser Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ile Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  30
<211>  327
<212>  DNA
<213>  Mus musculus

<400>  30
caggctgttg tgactcagga atctgcactc tccacatcac ctggtgaaac agtcacactc       60

acttgtcgct caattactgg ggctgttaca actagtaact atgccaactg ggtccaagaa      120

aaaccagatc atttgttcac tggtctaata ggtggtacca acaaccgagc tccaggtgtt      180

cctgccagat tctcaggctc cctgattgga gacaaggctg ccctcaccat cacaggggca      240

cagactgagg atgaggcaat atatttctgt gctctatggt acagcaacca ctgggtgttc      300

ggtggaggaa ccaaactgac tgtccta                                          327


<210>  31
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Heavy chain variable region amino acid sequence of a murine-human
       chimeric antibody

<400>  31

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  32
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Light chain variable region amino acid sequence of a murine-human
       chimeric antibody

<400>  32

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ile Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr 
        35                  40                  45              


Leu Ile Tyr Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  33
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized heavy chain variable region amino acid sequence

<400>  33

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  34
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized heavy chain variable region amino acid sequence

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  35
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized heavy chain variable region amino acid sequence

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  36
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized light chain variable region amino acid sequence

<400>  36

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ile Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  37
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized light chain variable region amino acid sequence

<400>  37

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ile Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  38
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized heavy chain amino acid sequence

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  39
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized heavy chain nucleic acid sequence

<400>  39
caggtgcagc tggtgcagtc tggagcagag gtgaagaagc caggagcctc tgtgaaggtg       60

agctgcaagg cctccggcta caccttcaca aactatggca tgagctgggt gcggcaggca      120

cctggacagg gactggagtg gatgggctgg atcaatacat actccggcga gtctacctat      180

gccgacgact tcaagggcag ggtgacaatg accacagaca cctctacaag caccgcctac      240

atggagctgc ggagcctgag atccgacgat accgccgtgt actattgtgc caggtccctg      300

aaccgcgata catggttcac ctattggggc cagggcacac tggtgaccgt gagctccgcc      360

agcaccaagg gcccttccgt gtttccactg gccccctcct ctaaatccac atctggcggc      420

accgccgccc tgggctgtct ggtgaaggac tacttcccag agcctgtgac agtgtcctgg      480

aactctggcg ccctgacatc cggcgtgcac acatttccag ccgtgctgca gagctccggc      540

ctgtacagcc tgtctagcgt ggtgacagtg ccctcctcta gcctgggcac acagacctat      600

atctgcaacg tgaatcacaa gccaagcaat accaaggtgg acaagaaggt ggagcccaag      660

tcctgtgata agacacacac ctgcccccct tgtcctgctc ccgagctgct gggcggccct      720

agcgtgttcc tgtttccacc caagcctaag gacaccctga tgatctcccg gacacccgag      780

gtgacctgcg tggtggtgga cgtgtctcac gaggatcctg aggtgaagtt caactggtat      840

gtggatggcg tggaggtgca caatgccaag accaagccca gagaggagca gtacaactct      900

acatataggg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg cccgccccca tcgagaagac aatcagcaag     1020

gccaagggcc agcctcggga gccacaggtg tacaccctgc ctccatccag agacgagctg     1080

acaaagaacc aggtgtctct gacatgtctg gtgaagggct tctatcctag cgatatcgcc     1140

gtggagtggg agtccaatgg ccagccagag aacaattaca agaccacacc ccctgtgctg     1200

gactccgatg gctccttctt tctgtattcc aagctgaccg tggataagtc tcggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagccc tgcataatca ctatactcag     1320

aaatccctgt ccctgtcacc tggaaag                                         1347


<210>  40
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized light chain amino acid sequence

<400>  40

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ile Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ala Asp Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  41
<211>  670
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized light chain nucleic acid sequence

<400>  41
cagacagtgg tgacccagga gcctagcttc tccgtgtctc caggaggaac cgtgacactg       60

acctgcaggt ctatcacagg cgccgtgacc acaagcaact acgccaattg ggtgcaggag      120

acaccaggac aggcaccaag gggactgatc ggaggaacca acaatagggc accaggagtg      180

cctgaccggt tcagcggatc catcctggga aacaaggccg ccctgacaat caccggagca      240

caggcagacg atgaggcaga ttacttctgt gccctgtggt attccaatca ctgggtgttt      300

ggcggcggca caaagctgac cgtgctgggg cagcccaagg ccgctcctag cgtgacactg      360

tttccccctt cctccgagga gctgcaggcc aacaaggcca ccctggtgtg cctgatctcc      420

gacttctatc ctggcgccgt gacagtggcc tggaaggctg attctagccc agtgaaggct      480

ggcgtggaga ccacaacccc ctccaagcag tctaacaata agtatgccgc ttcctcttac      540

ctgagcctga caccagagca gtggaagtcc caccggtctt acagctgcca ggtcactcac      600

gaaggctcta ccgtggaaaa gacagtcgca cccaccgaat gctcatgata agcttaaggg      660

ttcgatccct                                                             670


<210>  42
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized heavy chain amino acid sequence

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Met Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  43
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized heavy chain nucleic acid sequence

<400>  43
caggtgcagc tggtgcagtc tggagcagag gtgaagaagc caggagcctc tgtgaaggtg       60

agctgcaagg cctccggcta caccttcaca aactatggca tgagctgggt gcggcaggca      120

cctggacagg gactggagtg gatgggctgg atcaatacat actccggcga gtctacctat      180

gccgacgatt tcaagggcag gtttaccatg acactggaca cctctacaag caccgcctac      240

atggagctgc ggagcctgag atccgacgat acagccgtgt atttctgtgc caggtccctg      300

aaccgcgata catggtttac ctactggggc cagggcacac tggtgaccgt gagctccgcc      360

agcaccaagg gcccttccgt gtttccactg gccccctcct ctaaatccac atctggcggc      420

accgccgccc tgggctgtct ggtgaaggac tacttcccag agcctgtgac agtgtcctgg      480

aactctggcg ccctgacatc cggcgtgcac acatttccag ccgtgctgca gagctccggc      540

ctgtacagcc tgtctagcgt ggtgacagtg ccctcctcta gcctgggcac acagacctat      600

atctgcaacg tgaatcacaa gccaagcaat accaaggtgg acaagaaggt ggagcccaag      660

tcctgtgata agacacacac ctgcccccct tgtcctgctc ccgagctgct gggcggccct      720

agcgtgttcc tgtttccacc caagcctaag gacaccctga tgatctcccg gacacccgag      780

gtgacctgcg tggtggtgga cgtgtctcac gaggatcctg aggtgaagtt caactggtat      840

gtggatggcg tggaggtgca caatgccaag accaagccca gagaggagca gtacaactct      900

acatataggg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg cccgccccca tcgagaagac aatcagcaag     1020

gccaagggcc agcctcggga gccacaggtg tacaccctgc ctccatccag agacgagctg     1080

acaaagaacc aggtgtctct gacatgtctg gtgaagggct tctatcctag cgatatcgcc     1140

gtggagtggg agtccaatgg ccagccagag aacaattaca agaccacacc ccctgtgctg     1200

gactccgatg gctccttctt tctgtattcc aagctgaccg tggataagtc tcggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagccc tgcataatca ctatactcag     1320

aaatccctgt ccctgtcacc tggaaag                                         1347


<210>  44
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized heavy chain amino acid sequence

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ser Gly Glu Ser Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Thr Leu Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Leu Asn Arg Asp Thr Trp Phe Thr Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  45
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized heavy chain nucleic acid sequence

<400>  45
caggtgcagc tggtgcagtc tggagcagag gtgaagaagc caggagcctc tgtgaaggtg       60

agctgcaagg cctccggcta caccttcaca aactatggca tgagctgggt gcggcaggca      120

cctggacagg gactggagtg gatgggctgg atcaatacat actccggcga gtctacctat      180

gccgacgact tcaagggcag gttcaccttt acactggaca cctctacaag caccgcctac      240

atggagctgc ggagcctgag atccgacgat acagccacct atttctgtgc caggtccctg      300

aaccgcgata catggtttac ctactggggc cagggcacac tggtgaccgt gagctccgcc      360

agcaccaagg gcccttccgt gtttccactg gccccctcct ctaaatccac atctggcggc      420

accgccgccc tgggctgtct ggtgaaggac tacttcccag agcctgtgac agtgtcctgg      480

aactctggcg ccctgacatc cggcgtgcac acatttccag ccgtgctgca gagctccggc      540

ctgtacagcc tgtctagcgt ggtgacagtg ccctcctcta gcctgggcac acagacctat      600

atctgcaacg tgaatcacaa gccaagcaat accaaggtgg acaagaaggt ggagcccaag      660

tcctgtgata agacacacac ctgcccccct tgtcctgctc ccgagctgct gggcggccct      720

agcgtgttcc tgtttccacc caagcctaag gacaccctga tgatctcccg gacacccgag      780

gtgacctgcg tggtggtgga cgtgtctcac gaggatcctg aggtgaagtt caactggtat      840

gtggatggcg tggaggtgca caatgccaag accaagccca gagaggagca gtacaactct      900

acatataggg tggtgagcgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag      960

tataagtgca aggtgtccaa taaggccctg cccgccccca tcgagaagac aatcagcaag     1020

gccaagggcc agcctcggga gccacaggtg tacaccctgc ctccatccag agacgagctg     1080

acaaagaacc aggtgtctct gacatgtctg gtgaagggct tctatcctag cgatatcgcc     1140

gtggagtggg agtccaatgg ccagccagag aacaattaca agaccacacc ccctgtgctg     1200

gactccgatg gctccttctt tctgtattcc aagctgaccg tggataagtc tcggtggcag     1260

cagggcaacg tgttcagctg ttccgtgatg cacgaagccc tgcataatca ctatactcag     1320

aaatccctgt ccctgtcacc tggaaag                                         1347


<210>  46
<211>  215
<212>  PRT
<213>  Artificial

<220>
<223>  Humanized light chain amino acid sequence

<400>  46

Gln Thr Val Val Thr Gln Glu Pro Ser Phe Ser Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ile Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ile Leu Gly Asn Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Ala Asp Asp Glu Ser Asp Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala 
145                 150                 155                 160 


Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala 
                165                 170                 175     


Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr 
        195                 200                 205             


Val Ala Pro Thr Glu Cys Ser 
    210                 215 


<210>  47
<211>  670
<212>  DNA
<213>  Artificial

<220>
<223>  Humanized light chain nucleic acid sequence

<400>  47
cagacagtgg tgacccagga gcctagcttc tccgtgtctc caggaggaac cgtgacactg       60

acctgcaggt ctatcacagg cgccgtgacc acaagcaact acgccaattg gtatcagcag      120

acaccaggac aggcaccaag gggactgatc ggaggaacca acaatagggc accaggagtg      180

cctgaccggt tcagcggatc catcctggga aacaaggccg ccctgacaat caccggagca      240

caggcagacg atgagtccga ttacttctgt gccctgtggt attctaatca ctgggtgttt      300

ggcggcggca caaagctgac cgtgctgggg cagcccaagg ccgctcctag cgtgacactg      360

tttccccctt cctccgagga gctgcaggcc aacaaggcca ccctggtgtg cctgatctcc      420

gacttctatc ctggcgccgt gacagtggcc tggaaggctg attctagccc agtgaaggct      480

ggcgtggaga ccacaacccc ctccaagcag tctaacaata agtatgccgc ttcctcttac      540

ctgagcctga caccagagca gtggaagtcc caccggtctt acagctgcca ggtcactcac      600

gaaggctcta ccgtggaaaa gacagtcgca cccaccgaat gctcatgata agcttaaggg      660

ttcgatccct                                                             670


<210>  48
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  48

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  49
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  49

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  50
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  50

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


