                         SEQUENCE LISTING

<110>  CITY OF HOPE
       THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120>  ENGINEERED ANTI-PROSTATE STEM CELL ANTIGEN FUSION PROTEINS AND 
       USES THEREOF

<130>  054435-8203.WO00

<150>  US 63/027,184
<151>  2020-05-19

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  1

Gly Ser Gly Gly Ser Ala Gln 
1               5           


<210>  2
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-Fc fusion protein


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (113)..(127)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (128)..(233)
<223>  VL

<220>
<221>  MISC_FEATURE
<222>  (234)..(240)
<223>  hinge

<220>
<221>  MISC_FEATURE
<222>  (241)..(349)
<223>  CH2

<220>
<221>  MISC_FEATURE
<222>  (350)..(456)
<223>  CH3

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Asp Pro Glu Tyr Gly Asp Ser Glu Phe Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Thr Gly Gly Phe Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ala Gln Asp 
        115                 120                 125             


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile His 
145                 150                 155                 160 


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Asp 
                165                 170                 175     


Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
        195                 200                 205             


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Gly Ser Ser Pro Phe Thr Phe 
    210                 215                 220                 


Gly Gln Gly Thr Lys Val Glu Ile Lys Val Glu Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  3
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-Fc fusion protein


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  VH

<220>
<221>  MISC_FEATURE
<222>  (113)..(127)
<223>  linker

<220>
<221>  MISC_FEATURE
<222>  (128)..(233)
<223>  VL

<220>
<221>  MISC_FEATURE
<222>  (234)..(240)
<223>  hinge

<220>
<221>  MISC_FEATURE
<222>  (241)..(349)
<223>  CH2

<220>
<221>  MISC_FEATURE
<222>  (350)..(456)
<223>  CH3

<400>  3

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Trp Ile Asp Pro Glu Tyr Gly Asp Ser Glu Phe Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Thr Gly Gly Phe Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ala Gln Asp 
        115                 120                 125             


Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp 
    130                 135                 140                 


Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Arg Phe Ile His 
145                 150                 155                 160 


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile Tyr Asp 
                165                 170                 175     


Thr Ser Lys Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
            180                 185                 190         


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
        195                 200                 205             


Phe Ala Thr Tyr Tyr Cys Gln Gln Trp Gly Ser Ser Pro Phe Thr Phe 
    210                 215                 220                 


Gly Gln Gly Thr Lys Val Glu Ile Lys Val Glu Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                245                 250                 255     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            260                 265                 270         


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        275                 280                 285             


Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    290                 295                 300                 


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val Ala Gln 
305                 310                 315                 320 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                325                 330                 335     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            340                 345                 350         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        355                 360                 365             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    370                 375                 380                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
385                 390                 395                 400 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                405                 410                 415     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            420                 425                 430         


Ser Cys Ser Val Met His Glu Ala Leu His Asn Gln Tyr Thr Gln Lys 
        435                 440                 445             


Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455     


<210>  4
<211>  114
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  signal peptide

<220>
<221>  MISC_FEATURE
<222>  (86)..(114)
<223>  propeptide

<400>  4

Met Ala Gly Leu Ala Leu Gln Pro Gly Thr Ala Leu Leu Cys Tyr Ser 
1               5                   10                  15      


Cys Lys Ala Gln Val Ser Asn Glu Asp Cys Leu Gln Val Glu Asn Cys 
            20                  25                  30          


Thr Gln Leu Gly Glu Gln Cys Trp Thr Ala Arg Ile Arg Ala Val Gly 
        35                  40                  45              


Leu Leu Thr Val Ile Ser Lys Gly Cys Ser Leu Asn Cys Val Asp Asp 
    50                  55                  60                  


Ser Gln Asp Tyr Tyr Val Gly Lys Lys Asn Ile Thr Cys Cys Asp Thr 
65                  70                  75                  80  


Asp Leu Cys Asn Ala Ser Gly Ala His Ala Leu Gln Pro Ala Ala Ala 
                85                  90                  95      


Ile Leu Ala Leu Leu Pro Ala Leu Gly Leu Leu Leu Trp Gly Pro Gly 
            100                 105                 110         


Gln Leu 
        


<210>  5
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  truncated residues

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  disulfide bridge

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  disulfide bridge

<400>  5

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
1               5                   10                  15      


Ala Gly Pro Ser 
            20  


