                         SEQUENCE LISTING

<110>  CONTRAFECT CORPORATION
 
<120>  MODIFIED PlySs2 LYSINS AND ANTIBIOTIC COMBINATIONS FOR USE 
       AGAINST GRAM-POSITIVE BACTERIA

<130>  0341.0027-00-304

<150>  63/026,954
<151>  2020-05-19

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  245
<212>  PRT
<213>  Streptococcus suis

<400>  1

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Leu Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Val Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Val 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Tyr Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Tyr Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  2
<211>  10
<212>  PRT
<213>  Streptococcus suis

<400>  2

Pro Pro Gly Thr Val Ala Gln Ser Ala Pro 
1               5                   10  


<210>  3
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  3

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Tyr Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  4
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  4

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Tyr Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu His Phe Asp Tyr Asp Thr Val Ile Glu Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  5
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  5

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Tyr Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Gln Phe Asp Tyr Asp Thr Ala Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Ala Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  6
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  6

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Lys Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asp Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Gln Phe Asp Tyr Asp Thr Ala Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Ala Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  7
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  7

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Lys Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asp Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  8
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  8

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Asn Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Glu Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  9
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  9

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Tyr Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asp Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu His Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  10
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  10

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Tyr Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asp Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Ala Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Ala Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  11
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  11

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Leu Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Val Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Val 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Tyr Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Asn Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asp Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Glu Gly Glu Ser Phe Asp Tyr Asp Thr Glu Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  12
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  12

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Glu Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Tyr Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  13
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  13

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Leu Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Val Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Lys Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  14
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  14

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Lys Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  15
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  15

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Lys Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Lys Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Glu Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  16
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  16

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Lys Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asp Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Gln Phe Asp Tyr Asp Thr Lys Ile Ile Asp Val 
        195                 200                 205             


Asn Gly Tyr Glu Trp Val Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


<210>  17
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polypeptide

<400>  17

Met Thr Thr Val Asn Glu Ala Leu Asn Asn Val Arg Ala Gln Val Gly 
1               5                   10                  15      


Ser Gly Val Ser Val Gly Asn Gly Glu Cys Tyr Ala Leu Ala Ser Trp 
            20                  25                  30          


Tyr Glu Arg Met Ile Ser Pro Asp Ala Thr Val Gly Leu Gly Ala Gly 
        35                  40                  45              


Val Gly Trp Val Ser Gly Ala Ile Gly Asp Thr Ile Ser Ala Lys Asn 
    50                  55                  60                  


Ile Gly Ser Ser Tyr Asn Trp Gln Ala Asn Gly Trp Thr Val Ser Thr 
65                  70                  75                  80  


Ser Gly Pro Phe Lys Ala Gly Gln Ile Val Thr Trp Gly Ala Thr Pro 
                85                  90                  95      


Gly Asn Pro Tyr Gly His Val Ser Ile Val Glu Ala Val Asp Gly Asp 
            100                 105                 110         


Arg Leu Thr Ile Leu Glu Gln Asn Tyr Gly Gly Lys Arg Tyr Pro Thr 
        115                 120                 125             


Arg Asn Tyr Tyr Ser Ala Ala Ser Ser Arg Gln Gln Val Val His Tyr 
    130                 135                 140                 


Ile Thr Pro Pro Gly Thr Val Ala Gln Ser Ala Pro Asn Leu Ala Gly 
145                 150                 155                 160 


Ser Arg Ser Lys Arg Glu Thr Gly Thr Met Thr Val Thr Val Asp Ala 
                165                 170                 175     


Leu Asn Val Arg Arg Ala Pro Asn Thr Ser Gly Glu Ile Val Ala Val 
            180                 185                 190         


Tyr Lys Arg Gly Glu Ser Phe Asp Tyr Asp Thr Val Ile Glu Asp Val 
        195                 200                 205             


Asn Gly Tyr Val Trp Gly Ser Tyr Ile Gly Gly Ser Gly Lys Arg Asn 
    210                 215                 220                 


Tyr Val Ala Thr Gly Ala Thr Lys Asp Gly Lys Arg Phe Gly Asn Ala 
225                 230                 235                 240 


Trp Gly Thr Phe Lys 
                245 


