                         SEQUENCE LISTING

<110>  Sackstein
       Sackstein, Robert
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF INFLAMMATORY DISORDERS

<130>  1077747.000036-PCT

<150>  63/026,629
<151>  2020-05-18    

<170>  PatentIn version 3.5

<210>  1
<211>  361
<212>  PRT
<213>  Homo sapiens

<400>  SEQ ID NO: 1

Met Asp Pro Leu Gly Ala Ala Lys Pro Gln Trp Pro Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Ala Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Ala Pro 
        35                  40                  45              


Ser Gly Ser Ser Arg Gln Asp Thr Thr Pro Thr Arg Pro Thr Leu Leu 
    50                  55                  60                  


Ile Leu Leu Trp Thr Trp Pro Phe His Ile Pro Val Ala Leu Ser Arg 
65                  70                  75                  80  


Cys Ser Glu Met Val Pro Gly Thr Ala Asp Cys His Ile Thr Ala Asp 
                85                  90                  95      


Arg Lys Val Tyr Pro Gln Ala Asp Thr Val Ile Val His His Trp Asp 
            100                 105                 110         


Ile Met Ser Asn Pro Lys Ser Arg Leu Pro Pro Ser Pro Arg Pro Gln 
        115                 120                 125             


Gly Gln Arg Trp Ile Trp Phe Asn Leu Glu Pro Pro Pro Asn Cys Gln 
    130                 135                 140                 


His Leu Glu Ala Leu Asp Arg Tyr Phe Asn Leu Thr Met Ser Tyr Arg 
145                 150                 155                 160 


Ser Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser 
                165                 170                 175     


Gly Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu 
            180                 185                 190         


Val Ala Trp Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg 
        195                 200                 205             


Tyr Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg 
    210                 215                 220                 


Ser His Lys Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg 
225                 230                 235                 240 


Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile 
                245                 250                 255     


Thr Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val 
            260                 265                 270         


Val Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp 
        275                 280                 285             


Ala Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg 
    290                 295                 300                 


Tyr Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe 
305                 310                 315                 320 


Arg Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Asp 
                325                 330                 335     


Phe Cys Lys Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr 
            340                 345                 350         


Val Arg Ser Ile Ala Ala Trp Phe Thr 
        355                 360     


<210>  2
<211>  1694
<212>  DNA
<213>  Homo sapiens

<400>  SEQ ID NO: 2

gagaaagcag gcaaccacca tgtcatttga aaacagtttc atcgggatat aattcgcaac       60

ccatacagtg aatccattta agatactctg acccatggat cccctgggtg cagccaagcc      120

acaatggcca tggcgccgct gtctggccgc actgctattt cagctgctgg tggctgtgtg      180

tttcttctcc tacctgcgtg tgtcccgaga cgatgccact ggatccccta gggctcccag      240

tgggtcctcc cgacaggaca ccactcccac ccgccccacc ctcctgatcc tgctatggac      300

atggcctttc cacatccctg tggctctgtc ccgctgttca gagatggtgc ccggcacagc      360

cgactgccac atcactgccg accgcaaggt gtacccacag gcagacacgg tcatcgtgca      420

ccactgggat atcatgtcca accctaagtc acgcctccca ccttccccga ggccgcaggg      480

gcagcgctgg atctggttca acttggagcc accccctaac tgccagcacc tggaagccct      540

ggacagatac ttcaatctca ccatgtccta ccgcagcgac tccgacatct tcacgcccta      600

cggctggctg gagccgtggt ccggccagcc tgcccaccca ccgctcaacc tctcggccaa      660

gaccgagctg gtggcctggg cggtgtccaa ctggaagccg gactcagcca gggtgcgcta      720

ctaccagagc ctgcaggctc atctcaaggt ggacgtgtac ggacgctccc acaagcccct      780

gcccaagggg accatgatgg agacgctgtc ccggtacaag ttctacctgg ccttcgagaa      840

ctccttgcac cccgactaca tcaccgagaa gctgtggagg aacgccctgg aggcctgggc      900

cgtgcccgtg gtgctgggcc ccagcagaag caactacgag aggttcctgc cacccgacgc      960

cttcatccac gtggacgact tccagagccc caaggacctg gcccggtacc tgcaggagct     1020

ggacaaggac cacgcccgct acctgagcta ctttcgctgg cgggagacgc tgcggcctcg     1080

ctccttcagc tgggcactgg atttctgcaa ggcctgctgg aaactgcagc aggaatccag     1140

gtaccagacg gtgcgcagca tagcggcttg gttcacctga gaggccggca tggtgcctgg     1200

gctgccggga acctcatctg cctggggcct cacctgctgg agtcctttgt ggccaaccct     1260

ctctcttacc tgggacctca cacgctgggc ttcacggctg ccaggagcct ctcccctcca     1320

gaagacttgc ctgctgggga cctcgcctgc tggggacctc gcctgttggg gacctcacct     1380

gctggggacc tcacctgctg gggaccttgg ctgctggagg ctgcacctac tgaggatgtc     1440

ggcggtcggg gactttacct gctgggacct gctcccagag accttgccac actgaatctc     1500

acctgctggg gacctcaccc tggagggccc tgggccctgg ggaactggct tacttggggc     1560

cccacccggg agtgatggtt ctggctgatt tgtttgtgat gttgttagcc gcctgtgagg     1620

ggtgcagaga gatcatcacg gcacggtttc cagatgtaat actgcaagga aaaaaaaaaa     1680

aaaaaaaaaa aaaa                                                       1694


<210>  3
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  SEQ ID NO: 3

Met Arg Arg Leu Trp Gly Ala Ala Arg Lys Pro Ser Gly Ala Gly Trp 
1               5                   10                  15      


Glu Lys Glu Trp Ala Glu Ala Pro Gln Glu Ala Pro Gly Ala Trp Ser 
            20                  25                  30          


Gly Arg Leu Gly Pro Gly Arg Ser Gly Arg Lys Gly Arg Ala Val Pro 
        35                  40                  45              


Gly Trp Ala Ser Trp Pro Ala His Leu Ala Leu Ala Ala Arg Pro Ala 
    50                  55                  60                  


Arg His Leu Gly Gly Ala Gly Gln Gly Pro Arg Pro Leu His Ser Gly 
65                  70                  75                  80  


Thr Ala Pro Phe His Ser Arg Ala Ser Gly Glu Arg Gln Arg Arg Leu 
                85                  90                  95      


Glu Pro Gln Leu Gln His Glu Ser Arg Cys Arg Ser Ser Thr Pro Ala 
            100                 105                 110         


Asp Ala Trp Arg Ala Glu Ala Ala Leu Pro Val Arg Ala Met Gly Ala 
        115                 120                 125             


Pro Trp Gly Ser Pro Thr Ala Ala Ala Gly Gly Arg Arg Gly Trp Arg 
    130                 135                 140                 


Arg Gly Arg Gly Leu Pro Trp Thr Val Cys Val Leu Ala Ala Ala Gly 
145                 150                 155                 160 


Leu Thr Cys Thr Ala Leu Ile Thr Tyr Ala Cys Trp Gly Gln Leu Pro 
                165                 170                 175     


Pro Leu Pro Trp Ala Ser Pro Thr Pro Ser Arg Pro Val Gly Val Leu 
            180                 185                 190         


Leu Trp Trp Glu Pro Phe Gly Gly Arg Asp Ser Ala Pro Arg Pro Pro 
        195                 200                 205             


Pro Asp Cys Arg Leu Arg Phe Asn Ile Ser Gly Cys Arg Leu Leu Thr 
    210                 215                 220                 


Asp Arg Ala Ser Tyr Gly Glu Ala Gln Ala Val Leu Phe His His Arg 
225                 230                 235                 240 


Asp Leu Val Lys Gly Pro Pro Asp Trp Pro Pro Pro Trp Gly Ile Gln 
                245                 250                 255     


Ala His Thr Ala Glu Glu Val Asp Leu Arg Val Leu Asp Tyr Glu Glu 
            260                 265                 270         


Ala Ala Ala Ala Ala Glu Ala Leu Ala Thr Ser Ser Pro Arg Pro Pro 
        275                 280                 285             


Gly Gln Arg Trp Val Trp Met Asn Phe Glu Ser Pro Ser His Ser Pro 
    290                 295                 300                 


Gly Leu Arg Ser Leu Ala Ser Asn Leu Phe Asn Trp Thr Leu Ser Tyr 
305                 310                 315                 320 


Arg Ala Asp Ser Asp Val Phe Val Pro Tyr Gly Tyr Leu Tyr Pro Arg 
                325                 330                 335     


Ser His Pro Gly Asp Pro Pro Ser Gly Leu Ala Pro Pro Leu Ser Arg 
            340                 345                 350         


Lys Gln Gly Leu Val Ala Trp Val Val Ser His Trp Asp Glu Arg Gln 
        355                 360                 365             


Ala Arg Val Arg Tyr Tyr His Gln Leu Ser Gln His Val Thr Val Asp 
    370                 375                 380                 


Val Phe Gly Arg Gly Gly Pro Gly Gln Pro Val Pro Glu Ile Gly Leu 
385                 390                 395                 400 


Leu His Thr Val Ala Arg Tyr Lys Phe Tyr Leu Ala Phe Glu Asn Ser 
                405                 410                 415     


Gln His Leu Asp Tyr Ile Thr Glu Lys Leu Trp Arg Asn Ala Leu Leu 
            420                 425                 430         


Ala Gly Ala Val Pro Val Val Leu Gly Pro Asp Arg Ala Asn Tyr Glu 
        435                 440                 445             


Arg Phe Val Pro Arg Gly Ala Phe Ile His Val Asp Asp Phe Pro Ser 
    450                 455                 460                 


Ala Ser Ser Leu Ala Ser Tyr Leu Leu Phe Leu Asp Arg Asn Pro Ala 
465                 470                 475                 480 


Val Tyr Arg Arg Tyr Phe His Trp Arg Arg Ser Tyr Ala Val His Ile 
                485                 490                 495     


Thr Ser Phe Trp Asp Glu Pro Trp Cys Arg Val Cys Gln Ala Val Gln 
            500                 505                 510         


Arg Ala Gly Asp Arg Pro Lys Ser Ile Arg Asn Leu Ala Ser Trp Phe 
        515                 520                 525             


Glu Arg 
    530 


<210>  4
<211>  2287
<212>  DNA
<213>  Homo sapiens

<400>  SEQ ID NO: 4

gcggcagctg ctttagaagg tctcgagcct cctgtacctt cccagggatg aaccgggcct       60

tccctctgga aggcgagggt tcgggccaca gtgagcgagg gccagggcgg tgggcgcgcg      120

cagagggaaa ccggatcagt tgagagagaa tcaagagtag cggatgaggc gcttgtgggg      180

cgcggcccgg aagccctcgg gcgcgggctg ggagaaggag tgggcggagg cgccgcagga      240

ggctcccggg gcctggtcgg gccggctggg ccccgggcgc agtggaagaa agggacgggc      300

ggtgcccggt tgggcgtcct ggccagctca ccttgccctg gcggctcgcc ccgcccggca      360

cttgggagga gcagggcagg gcccgcggcc tttgcattct gggaccgccc ccttccattc      420

ccgggccagc ggcgagcggc agcgacggct ggagccgcag ctacagcatg agagccggtg      480

ccgctcctcc acgcctgcgg acgcgtggcg agcggaggca gcgctgcctg ttcgcgccat      540

gggggcaccg tggggctcgc cgacggcggc ggcgggcggg cggcgcgggt ggcgccgagg      600

ccgggggctg ccatggaccg tctgtgtgct ggcggccgcc ggcttgacgt gtacggcgct      660

gatcacctac gcttgctggg ggcagctgcc gccgctgccc tgggcgtcgc caaccccgtc      720

gcgaccggtg ggcgtgctgc tgtggtggga gcccttcggg gggcgcgata gcgccccgag      780

gccgccccct gactgccggc tgcgcttcaa catcagcggc tgccgcctgc tcaccgaccg      840

cgcgtcctac ggagaggctc aggccgtgct tttccaccac cgcgacctcg tgaaggggcc      900

ccccgactgg cccccgccct ggggcatcca ggcgcacact gccgaggagg tggatctgcg      960

cgtgttggac tacgaggagg cagcggcggc ggcagaagcc ctggcgacct ccagccccag     1020

gcccccgggc cagcgctggg tttggatgaa cttcgagtcg ccctcgcact ccccggggct     1080

gcgaagcctg gcaagtaacc tcttcaactg gacgctctcc taccgggcgg actcggacgt     1140

ctttgtgcct tatggctacc tctaccccag aagccacccc ggcgacccgc cctcaggcct     1200

ggccccgcca ctgtccagga aacaggggct ggtggcatgg gtggtgagcc actgggacga     1260

gcgccaggcc cgggtccgct actaccacca actgagccaa catgtgaccg tggacgtgtt     1320

cggccggggc gggccggggc agccggtgcc cgaaattggg ctcctgcaca cagtggcccg     1380

ctacaagttc tacctggctt tcgagaactc gcagcacctg gattatatca ccgagaagct     1440

ctggcgcaac gcgttgctcg ctggggcggt gccggtggtg ctgggcccag accgtgccaa     1500

ctacgagcgc tttgtgcccc gcggcgcctt catccacgtg gacgacttcc caagtgcctc     1560

ctccctggcc tcgtacctgc ttttcctcga ccgcaacccc gcggtctatc gccgctactt     1620

ccactggcgc cggagctacg ctgtccacat cacctccttc tgggacgagc cttggtgccg     1680

ggtgtgccag gctgtacaga gggctgggga ccggcccaag agcatacgga acttggccag     1740

ctggttcgag cggtgaagcc gcgctcccct ggaagcgacc caggggaggc caagttgtca     1800

gctttttgat cctctactgt gcatctcctt gactgccgca tcatgggagt aagttcttca     1860

aacacccatt tttgctctat gggaaaaaaa cgatttacca attaatatta ctcagcacag     1920

agatgggggc ccggtttcca tattttttgc acagctagca attgggctcc ctttgctgct     1980

gatgggcatc attgtttagg ggtgaaggag ggggttcttc ctcaccttgt aaccagtgca     2040

gaaatgaaat agcttagcgg caagaagccg ttgaggcggt ttcctgaatt tccccatctg     2100

ccacaggcca tatttgtggc ccgtgcagct tccaaatctc atacacaact gttcccgatt     2160

cacgtttttc tggaccaagg tgaagcaaat ttgtggttgt agaaggagcc ttgttggtgg     2220

agagtggaag gactgtggct gcaggtggga ctttgttgtt tggattcctc acagccttgg     2280

ctcctga                                                               2287


<210>  5
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  SEQ ID NO: 5

Met Gly Ala Pro Trp Gly Ser Pro Thr Ala Ala Ala Gly Gly Arg Arg 
1               5                   10                  15      


Gly Trp Arg Arg Gly Arg Gly Leu Pro Trp Thr Val Cys Val Leu Ala 
            20                  25                  30          


Ala Ala Gly Leu Thr Cys Thr Ala Leu Ile Thr Tyr Ala Cys Trp Gly 
        35                  40                  45              


Gln Leu Pro Pro Leu Pro Trp Ala Ser Pro Thr Pro Ser Arg Pro Val 
    50                  55                  60                  


Gly Val Leu Leu Trp Trp Glu Pro Phe Gly Gly Arg Asp Ser Ala Pro 
65                  70                  75                  80  


Arg Pro Pro Pro Asp Cys Arg Leu Arg Phe Asn Ile Ser Gly Cys Arg 
                85                  90                  95      


Leu Leu Thr Asp Arg Ala Ser Tyr Gly Glu Ala Gln Ala Val Leu Phe 
            100                 105                 110         


His His Arg Asp Leu Val Lys Gly Pro Pro Asp Trp Pro Pro Pro Trp 
        115                 120                 125             


Gly Ile Gln Ala His Thr Ala Glu Glu Val Asp Leu Arg Val Leu Asp 
    130                 135                 140                 


Tyr Glu Glu Ala Ala Ala Ala Ala Glu Ala Leu Ala Thr Ser Ser Pro 
145                 150                 155                 160 


Arg Pro Pro Gly Gln Arg Trp Val Trp Met Asn Phe Glu Ser Pro Ser 
                165                 170                 175     


His Ser Pro Gly Leu Arg Ser Leu Ala Ser Asn Leu Phe Asn Trp Thr 
            180                 185                 190         


Leu Ser Tyr Arg Ala Asp Ser Asp Val Phe Val Pro Tyr Gly Tyr Leu 
        195                 200                 205             


Tyr Pro Arg Ser His Pro Gly Asp Pro Pro Ser Gly Leu Ala Pro Pro 
    210                 215                 220                 


Leu Ser Arg Lys Gln Gly Leu Val Ala Trp Val Val Ser His Trp Asp 
225                 230                 235                 240 


Glu Arg Gln Ala Arg Val Arg Tyr Tyr His Gln Leu Ser Gln His Val 
                245                 250                 255     


Thr Val Asp Val Phe Gly Arg Gly Gly Pro Gly Gln Pro Val Pro Glu 
            260                 265                 270         


Ile Gly Leu Leu His Thr Val Ala Arg Tyr Lys Phe Tyr Leu Ala Phe 
        275                 280                 285             


Glu Asn Ser Gln His Leu Asp Tyr Ile Thr Glu Lys Leu Trp Arg Asn 
    290                 295                 300                 


Ala Leu Leu Ala Gly Ala Val Pro Val Val Leu Gly Pro Asp Arg Ala 
305                 310                 315                 320 


Asn Tyr Glu Arg Phe Val Pro Arg Gly Ala Phe Ile His Val Asp Asp 
                325                 330                 335     


Phe Pro Ser Ala Ser Ser Leu Ala Ser Tyr Leu Leu Phe Leu Asp Arg 
            340                 345                 350         


Asn Pro Ala Val Tyr Arg Arg Tyr Phe His Trp Arg Arg Ser Tyr Ala 
        355                 360                 365             


Val His Ile Thr Ser Phe Trp Asp Glu Pro Trp Cys Arg Val Cys Gln 
    370                 375                 380                 


Ala Val Gln Arg Ala Gly Asp Arg Pro Lys Ser Ile Arg Asn Leu Ala 
385                 390                 395                 400 


Ser Trp Phe Glu Arg 
                405 


<210>  6
<211>  1215
<212>  DNA
<213>  Homo sapiens

<400>  SEQ ID NO: 6

atgggggcac cgtggggctc gccgacggcg gcggcgggcg ggcggcgcgg gtggcgccga       60

ggccgggggc tgccatggac cgtctgtgtg ctggcggccg ccggcttgac gtgtacggcg      120

ctgatcacct acgcttgctg ggggcagctg ccgccgctgc cctgggcgtc gccaaccccg      180

tcgcgaccgg tgggcgtgct gctgtggtgg gagcccttcg gggggcgcga tagcgccccg      240

aggccgcccc ctgactgccg gctgcgcttc aacatcagcg gctgccgcct gctcaccgac      300

cgcgcgtcct acggagaggc tcaggccgtg cttttccacc accgcgacct cgtgaagggg      360

ccccccgact ggcccccgcc ctggggcatc caggcgcaca ctgccgagga ggtggatctg      420

cgcgtgttgg actacgagga ggcagcggcg gcggcagaag ccctggcgac ctccagcccc      480

aggcccccgg gccagcgctg ggtttggatg aacttcgagt cgccctcgca ctccccgggg      540

ctgcgaagcc tggcaagtaa cctcttcaac tggacgctct cctaccgggc ggactcggac      600

gtctttgtgc cttatggcta cctctacccc agaagccacc ccggcgaccc gccctcaggc      660

ctggccccgc cactgtccag gaaacagggg ctggtggcat gggtggtgag ccactgggac      720

gagcgccagg cccgggtccg ctactaccac caactgagcc aacatgtgac cgtggacgtg      780

ttcggccggg gcgggccggg gcagccggtg cccgaaattg ggctcctgca cacagtggcc      840

cgctacaagt tctacctggc tttcgagaac tcgcagcacc tggattatat caccgagaag      900

ctctggcgca acgcgttgct cgctggggcg gtgccggtgg tgctgggccc agaccgtgcc      960

aactacgagc gctttgtgcc ccgcggcgcc ttcatccacg tggacgactt cccaagtgcc     1020

tcctccctgg cctcgtacct gcttttcctc gaccgcaacc ccgcggtcta tcgccgctac     1080

ttccactggc gccggagcta cgctgtccac atcacctcct tctgggacga gccttggtgc     1140

cgggtgtgcc aggctgtaca gagggctggg gaccggccca agagcatacg gaacttggcc     1200

agctggttcg agcgg                                                      1215


<210>  7
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  SEQ ID NO: 7

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Leu Trp Arg Arg Cys 
1               5                   10                  15      


Leu Ala Gly Leu Leu Phe Gln Leu Leu Val Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Arg Asp Asp Ala Thr Gly Ser Pro Arg Pro Gly 
        35                  40                  45              


Leu Met Ala Val Glu Pro Val Thr Gly Ala Pro Asn Gly Ser Arg Cys 
    50                  55                  60                  


Gln Asp Ser Met Ala Thr Pro Ala His Pro Thr Leu Leu Ile Leu Leu 
65                  70                  75                  80  


Trp Thr Trp Pro Phe Asn Thr Pro Val Ala Leu Pro Arg Cys Ser Glu 
                85                  90                  95      


Met Val Pro Gly Ala Ala Asp Cys Asn Ile Thr Ala Asp Ser Ser Val 
            100                 105                 110         


Tyr Pro Gln Ala Asp Ala Val Ile Val His His Trp Asp Ile Met Tyr 
        115                 120                 125             


Asn Pro Ser Ala Asn Leu Pro Pro Pro Thr Arg Pro Gln Gly Gln Arg 
    130                 135                 140                 


Trp Ile Trp Phe Ser Met Glu Ser Pro Ser Asn Cys Arg His Leu Glu 
145                 150                 155                 160 


Ala Leu Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser Asp Ser 
                165                 170                 175     


Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly Gln Pro 
            180                 185                 190         


Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val Ala Trp 
        195                 200                 205             


Ala Val Ser Asn Trp Lys Pro Asp Ser Ala Arg Val Arg Tyr Tyr Gln 
    210                 215                 220                 


Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser His Lys 
225                 230                 235                 240 


Pro Leu Pro Lys Gly Thr Met Met Glu Thr Leu Ser Arg Tyr Lys Phe 
                245                 250                 255     


Tyr Leu Ala Phe Glu Asn Ser Leu His Pro Asp Tyr Ile Thr Glu Lys 
            260                 265                 270         


Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val Leu Gly 
        275                 280                 285             


Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala Phe Ile 
    290                 295                 300                 


His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr Leu Gln 
305                 310                 315                 320 


Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg Trp Arg 
                325                 330                 335     


Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe Cys Lys 
            340                 345                 350         


Ala Cys Trp Lys Leu Gln Gln Glu Ser Arg Tyr Gln Thr Val Arg Ser 
        355                 360                 365             


Ile Ala Ala Trp Phe Thr 
    370                 


<210>  8
<211>  1487
<212>  DNA
<213>  Homo sapiens

<400>  SEQ ID NO: 8

acagacatga gccacctcgc ccagcctttt catggctgag tgatattcca ttgtgtggat       60

ggatcacact agctactctg acccatggat cccctgggcc cagccaagcc acagtggctg      120

tggcgccgct gtctggccgg gctgctgttt cagctgctgg tggctgtgtg tttcttctcc      180

tacctgcgtg tgtcccgaga cgatgccact ggatccccta ggccagggct tatggcagtg      240

gaacctgtca ccggggctcc caatgggtcc cgctgccagg acagcatggc gacccctgcc      300

caccccaccc tactgatcct gctgtggacg tggcctttta acacacccgt ggctctgccc      360

cgctgctcag agatggtgcc cggcgcggcc gactgcaaca tcactgccga ctccagtgtg      420

tacccacagg cagacgcggt catcgtgcac cactgggata tcatgtacaa ccccagtgcc      480

aacctcccgc cccccaccag gccgcagggg cagcgctgga tctggttcag catggagtcc      540

cccagcaact gccggcacct ggaagccctg gacggatact tcaatctcac catgtcctac      600

cgcagcgact ccgacatctt cacgccctat ggctggctgg agccgtggtc cggccagcct      660

gcccacccac cgctcaacct ctcggccaag accgagctgg tggcctgggc ggtgtccaac      720

tggaagccgg actcggccag ggtgcgctac taccagagcc tgcaggctca tctcaaggtg      780

gacgtgtacg gacgctccca caagcccctg cccaagggga ccatgatgga gacgctgtcc      840

cggtacaagt tctatctggc cttcgagaac tccttgcacc ccgactacat caccgagaag      900

ctgtggagga acgccctgga ggcctgggcc gtgcccgtgg tgctgggccc cagcagaagc      960

aactacgaga ggttcctgcc acccgacgcc ttcatccacg tggatgactt ccagagcccc     1020

aaggacctgg cccggtacct gcaggagctg gacaaggacc acgcccgcta cctgagctac     1080

tttcgctggc gggagacgct gcggcctcgc tccttcagct gggcactggc tttctgcaag     1140

gcctgctgga agctgcagca ggaatccagg taccagacgg tgcgcagcat agcggcttgg     1200

ttcacctgag aggccggcat ggggcctggg ctgccaggac ctcactttcc cagggcctca     1260

cctacctagg gtctcactag tcgggggatt tacctacctg gggcctcggc tgcctggggt     1320

ctcacctgcc tggggcctca cctgctggag tctttggtgg ccaggcatgt gacttacctg     1380

ggatttcact tgccgggctt cactgccagg agcctcccct gctggggacc ttgccagctg     1440

gggctgggga tggtgcctac tggggacctt gctttctgga ggctgca                   1487


<210>  9
<211>  359
<212>  PRT
<213>  Homo sapiens

<400>  SEQ ID NO: 9

Met Asp Pro Leu Gly Pro Ala Lys Pro Gln Trp Ser Trp Arg Cys Cys 
1               5                   10                  15      


Leu Thr Thr Leu Leu Phe His Leu Leu Met Ala Val Cys Phe Phe Ser 
            20                  25                  30          


Tyr Leu Arg Val Ser Gln Asp Asp Pro Thr Val Tyr Pro Asn Gly Ser 
        35                  40                  45              


Arg Phe Pro Asp Ser Thr Gly Thr Pro Ala His Ser Ile Pro Leu Ile 
    50                  55                  60                  


Leu Leu Trp Thr Trp Pro Phe Asn Lys Pro Ile Ala Leu Pro Arg Cys 
65                  70                  75                  80  


Ser Glu Met Val Pro Gly Thr Ala Asp Cys Asn Ile Thr Ala Asp Arg 
                85                  90                  95      


Lys Val Tyr Pro Gln Ala Asp Ala Val Ile Val His His Arg Glu Val 
            100                 105                 110         


Met Tyr Asn Pro Ser Ala Gln Leu Pro Arg Ser Ser Arg Arg Gln Gly 
        115                 120                 125             


Gln Arg Trp Ile Trp Phe Ser Met Glu Ser Pro Ser His Cys Trp Gln 
    130                 135                 140                 


Leu Lys Ala Met Asp Gly Tyr Phe Asn Leu Thr Met Ser Tyr Arg Ser 
145                 150                 155                 160 


Asp Ser Asp Ile Phe Thr Pro Tyr Gly Trp Leu Glu Pro Trp Ser Gly 
                165                 170                 175     


Gln Pro Ala His Pro Pro Leu Asn Leu Ser Ala Lys Thr Glu Leu Val 
            180                 185                 190         


Ala Trp Ala Val Ser Asn Trp Gly Pro Asn Ser Ala Arg Val Arg Tyr 
        195                 200                 205             


Tyr Gln Ser Leu Gln Ala His Leu Lys Val Asp Val Tyr Gly Arg Ser 
    210                 215                 220                 


His Lys Pro Leu Pro Gln Gly Thr Met Met Glu Thr Leu Ser Arg Tyr 
225                 230                 235                 240 


Lys Phe Tyr Leu Ala Phe Lys Asn Ser Leu His Pro Asp Tyr Ile Thr 
                245                 250                 255     


Glu Lys Leu Trp Arg Asn Ala Leu Glu Ala Trp Ala Val Pro Val Val 
            260                 265                 270         


Leu Gly Pro Ser Arg Ser Asn Tyr Glu Arg Phe Leu Pro Pro Asp Ala 
        275                 280                 285             


Phe Ile His Val Asp Asp Phe Gln Ser Pro Lys Asp Leu Ala Arg Tyr 
    290                 295                 300                 


Leu Gln Glu Leu Asp Lys Asp His Ala Arg Tyr Leu Ser Tyr Phe Arg 
305                 310                 315                 320 


Trp Arg Glu Thr Leu Arg Pro Arg Ser Phe Ser Trp Ala Leu Ala Phe 
                325                 330                 335     


Cys Lys Ala Cys Trp Lys Leu Gln Glu Glu Ser Arg Tyr Gln Thr Arg 
            340                 345                 350         


Gly Ile Ala Ala Trp Phe Thr 
        355                 


<210>  10
<211>  2875
<212>  DNA
<213>  Homo sapiens

<400>  SEQ ID NO: 10

ggggagatca tttctctcca ttccaggaag tttgcatagc tccctggact tctgctttgc       60

actgccctgc aggagtgggt ggggaaagga agtggctttg aggcacacag aggggcttgg      120

tgaggccacc ggaggaagct tctgccacca atatgggacc tgtgcccagc ctaccagaag      180

agagcatctg aaaacatgta tcgacatggt aacccctctg cttgaagcct cacatggctc      240

cctattgcct tggtgctgaa caccctatgg ctgaccgtgg cccagcctct gcaacagctc      300

tgcctcctct ccagtggtga agacccagcc tgctgagact cctcctgcag ttcctcaaca      360

tgcctgcatt tctgctgcct cagggccttt gcgaaggttg ttccttgtaa ctggaatgcc      420

cttccatccc ttttttattc aaaaggctgc aattttaatt gaagaaagtt cccttccaag      480

gttcatgagt tgcctgactt gcccaccggt ttcctgcaag atcccttggc ctggcactta      540

gtgctcagga aatatttggt gatgggccaa ctgagtgaga aggtgggatc tggtgggaag      600

gaaagcggaa aggtagaaat tctgctcact tcctcattcc cacctcccaa ggaacccctg      660

gtgtccctgt ggaacccgct ttgggaaccg gtggttcagg tcagcctttt cactttgtac      720

tcaaagccac atcgcattga agccacaggt ggggcaaggt catgcatgac ctgagtctcc      780

aaatcccttc accctgtttg gttctgcaac ggggattagg ggagccccac gatttgtttt      840

caaaggatgt ccgggctcca ggacaggatg ccctgggtca cctgatgaca ggtgtggtgg      900

ttggaaaggg cctggtttca gctccgggta cacttcctcc ttccttctgc tgcgtggtgt      960

ggcctcttcc acgtcctcag aatccagctg ttactccgtc cgcggcctct cagctctagg     1020

gccctctgca cactggcccc cccagatact ctgacccatg gatcccctgg gcccggccaa     1080

gccacagtgg tcgtggcgct gctgtctgac cacgctgctg tttcacctgc tgatggctgt     1140

gtgtttcttc tcctatctgc gtgtgtctca agacgatccc actgtgtacc ctaatgggtc     1200

ccgcttccca gacagcacag ggacccccgc ccactccatc cccctgatcc tgctgtggac     1260

gtggcctttt aacaaaccca tagctctgcc ccgctgctca gagatggtgc ctggcacggc     1320

tgactgcaac atcactgccg accgcaaggt gtatccacag gcagacgcgg tcatcgtgca     1380

ccaccgagag gtcatgtaca accccagtgc ccagctccca cgctcctcga ggcggcaggg     1440

gcagcgatgg atctggttca gcatggagtc cccaagccac tgctggcagc tgaaagccat     1500

ggacggatac ttcaatctca ccatgtccta ccgcagcgac tccgacatct tcacgcccta     1560

cggctggctg gagccgtggt ccggccagcc tgcccaccca ccgctcaacc tctcggccaa     1620

gaccgagctg gtggcctggg cagtgtccaa ctgggggcca aactccgcca gggtgcgcta     1680

ctaccagagc ctgcaggccc atctcaaggt ggacgtgtac ggacgctccc acaagcccct     1740

gccccaggga accatgatgg agacgctgtc ccggtacaag ttctatctgg ccttcaagaa     1800

ctccttgcac cccgactaca tcaccgagaa gctgtggagg aacgccctgg aggcctgggc     1860

cgtgcccgtg gtgctgggcc ccagcagaag caactacgag aggttcctgc cgcccgacgc     1920

cttcatccac gtggacgact tccagagccc caaggacctg gcccggtacc tgcaggagct     1980

ggacaaggac cacgcccgct acctgagcta ctttcgctgg cgggagacgc tgcggcctcg     2040

ctccttcagc tgggcactcg ctttctgcaa ggcctgctgg aaactgcagg aggaatccag     2100

gtaccagaca cgcggcatag cggcttggtt cacctgagag gctggtgtgg ggcctgggct     2160

gccaggaacc tcattttcct ggggcctcac ctgagtgggg gcctcatcta cctaaggact     2220

cgtttgcctg aagcttcacc tgcctgagga ctcacctgcc tgggacggtc acctgttgca     2280

gcttcacctg cctggggatt cacctacctg ggtcctcact ttcctggggc ctcacctgct     2340

ggagtcttcg gtggccaggt atgtccctta cctgggattt cacatgctgg cttccaggag     2400

cgtcccctgc ggaagcctgg cctgctgggg atgtctcctg gggactttgc ctactgggga     2460

cctcggctgt tggggacttt acctgctggg acctgctccc agagaccttc cacactgaat     2520

ctcacctgct aggagcctca cctgctgggg acctcaccct ggagggcact gggccctggg     2580

aactggcacc catggggccc cacccatgag tgatggttct ggctgatttg tttgtgatgt     2640

tgttagccgc ctgtgagggg tgcagagaga taatcaccgc accgtttcca gatgtaatac     2700

tgcaaagaaa accgatgatg aggccgggtg cggtggctca cacctgtaat cccagcactt     2760

tgggaggccg aggcaggcgg atcacaaggt caggagatcg agaccatcct ggccaatatg     2820

gtgaaacccg tctctactaa aaatacaaaa aaaaaaaaaa aaaaaaaaaa aaaaa          2875


<210>  11
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  SEQ ID NO: 11

Met Asn Asn Ala Gly His Gly Pro Thr Arg Arg Leu Arg Gly Leu Gly 
1               5                   10                  15      


Val Leu Ala Gly Val Ala Leu Leu Ala Ala Leu Trp Leu Leu Trp Leu 
            20                  25                  30          


Leu Gly Ser Ala Pro Arg Gly Thr Pro Ala Pro Gln Pro Thr Ile Thr 
        35                  40                  45              


Ile Leu Val Trp His Trp Pro Phe Thr Asp Gln Pro Pro Glu Leu Pro 
    50                  55                  60                  


Ser Asp Thr Cys Thr Arg Tyr Gly Ile Ala Arg Cys His Leu Ser Ala 
65                  70                  75                  80  


Asn Arg Ser Leu Leu Ala Ser Ala Asp Ala Val Val Phe His His Arg 
                85                  90                  95      


Glu Leu Gln Thr Arg Arg Ser His Leu Pro Leu Ala Gln Arg Pro Arg 
            100                 105                 110         


Gly Gln Pro Trp Val Trp Ala Ser Met Glu Ser Pro Ser His Thr His 
        115                 120                 125             


Gly Leu Ser His Leu Arg Gly Ile Phe Asn Trp Val Leu Ser Tyr Arg 
    130                 135                 140                 


Arg Asp Ser Asp Ile Phe Val Pro Tyr Gly Arg Leu Glu Pro His Trp 
145                 150                 155                 160 


Gly Pro Ser Pro Pro Leu Pro Ala Lys Ser Arg Val Ala Ala Trp Val 
                165                 170                 175     


Val Ser Asn Phe Gln Glu Arg Gln Leu Arg Ala Arg Leu Tyr Arg Gln 
            180                 185                 190         


Leu Ala Pro His Leu Arg Val Asp Val Phe Gly Arg Ala Asn Gly Arg 
        195                 200                 205             


Pro Leu Cys Ala Ser Cys Leu Val Pro Thr Val Ala Gln Tyr Arg Phe 
    210                 215                 220                 


Tyr Leu Ser Phe Glu Asn Ser Gln His Arg Asp Tyr Ile Thr Glu Lys 
225                 230                 235                 240 


Phe Trp Arg Asn Ala Leu Val Ala Gly Thr Val Pro Val Val Leu Gly 
                245                 250                 255     


Pro Pro Arg Ala Thr Tyr Glu Ala Phe Val Pro Ala Asp Ala Phe Val 
            260                 265                 270         


His Val Asp Asp Phe Gly Ser Ala Arg Glu Leu Ala Ala Phe Leu Thr 
        275                 280                 285             


Gly Met Asn Glu Ser Arg Tyr Gln Arg Phe Phe Ala Trp Arg Asp Arg 
    290                 295                 300                 


Leu Arg Val Arg Leu Phe Thr Asp Trp Arg Glu Arg Phe Cys Ala Ile 
305                 310                 315                 320 


Cys Asp Arg Tyr Pro His Leu Pro Arg Ser Gln Val Tyr Glu Asp Leu 
                325                 330                 335     


Glu Gly Trp Phe Gln Ala 
            340         


<210>  12
<211>  1101
<212>  DNA
<213>  Homo sapiens

<400>  SEQ ID NO: 12

gctgactgat cctgggagac tgtggatgaa taatgctggg cacggcccca cccggaggct       60

gcgaggcttg ggggtcctgg ccggggtggc tctgctcgct gccctctggc tcctgtggct      120

gctggggtca gcccctcggg gtaccccggc accccagccc acgatcacca tccttgtctg      180

gcactggccc ttcactgacc agcccccaga gctgcccagc gacacctgca cccgctacgg      240

catcgcccgc tgccacctga gtgccaaccg aagcctgctg gccagcgccg acgccgtggt      300

cttccaccac cgcgagctgc agacccggcg gtcccacctg cccctggccc agcggccgcg      360

agggcagccc tgggtgtggg cctccatgga gtctcctagc cacacccacg gcctcagcca      420

cctccgaggc atcttcaact gggtgctgag ctaccggcgc gactcggaca tctttgtgcc      480

ctatggccgc ctggagcccc actgggggcc ctcgccaccg ctgccagcca agagcagggt      540

ggccgcctgg gtggtcagca acttccagga gcggcagctg cgtgccaggc tgtaccggca      600

gctggcgcct catctgcggg tggatgtctt tggccgtgcc aatggacggc cactgtgcgc      660

cagctgcctg gtgcccaccg tggcccagta ccgcttctac ctgtcctttg agaactctca      720

gcaccgcgac tacattacgg agaaattctg gcgcaacgca ctggtggctg gcactgtgcc      780

agtggtgctg gggcccccac gggccaccta tgaggccttc gtgccggctg acgccttcgt      840

gcatgtggat gactttggct cagcccgaga gctggcggct ttcctcactg gcatgaatga      900

gagccgatac caacgcttct ttgcctggcg tgacaggctc cgcgtgcgac tgttcaccga      960

ctggcgggaa cgtttctgtg ccatctgtga ccgctaccca cacctacccc gcagccaagt     1020

ctatgaggac cttgagggtt ggtttcaggc ctgagatccg ctggccgggg gaggtgggtg     1080

tgggtggaag ggctgggtgt c                                               1101



