                         SEQUENCE LISTING

<110>  Vigene Biosciences Inc.
       Sun, Zairen
 
<120>  Covid-19 Vaccine Using Non-Integrating Lentiviral Vectors

<130>  2650.0005PCT

<150>  US 16/877,839
<151>  2020-05-19

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  380
<212>  DNA
<213>  Human Cytomegalovirus (CMV)


<220>
<221>  misc_feature
<222>  (1)..(380)
<223>  Human Cytomegalovirus (CMV) Immediate Early Enhancer Site

<400>  1
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  2
<211>  380
<212>  DNA
<213>  Human Cytomegalovirus (CMV)


<220>
<221>  misc_feature
<222>  (1)..(380)
<223>  Variant Human Cytomegalovirus (CMV) Immediate Early Enhancer Site

<400>  2
gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc       60

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca      120

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      180

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      240

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      300

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat      360

tagtcatcgc tattaccatg                                                  380


<210>  3
<211>  200
<212>  DNA
<213>  Human Cytomegalovirus (CMV)


<220>
<221>  misc_feature
<222>  (1)..(200)
<223>  Human Cytomegalovirus (CMV) Immediate Early Promoter Site

<400>  3
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag                                                  200


<210>  4
<211>  204
<212>  DNA
<213>  Human Cytomegalovirus (CMV)


<220>
<221>  misc_feature
<222>  (1)..(204)
<223>  Variant Human Cytomegalovirus (CMV) Immediate Early Promoter Site

<400>  4
gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  5
<211>  181
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(181)
<223>  Truncated Lentiviral 5' LTR region (R and U5 Regions)

<400>  5
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctagc      180

a                                                                      181


<210>  6
<211>  126
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(126)
<223>  Lentiviral LTR Psi Region

<400>  6
ctctctcgac gcaggactcg gcttgctgaa gcgcgcacgg caagaggcga ggggcggcga       60

ctggtgagta cgccaaaaat tttgactagc ggaggctaga aggagagaga tgggtgcgag      120

agcgtc                                                                 126


<210>  7
<211>  234
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(234)
<223>  Lentiviral REV Response Element (RRE)

<400>  7
aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat       60

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt      120

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca      180

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcct            234


<210>  8
<211>  118
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(118)
<223>  Lentiviral Central Polypurine Tract and Central Termination 
       Sequence (cPPT/CTS)

<400>  8
ttttaaaaga aaagggggga ttggggggta cagtgcaggg gaaagaatag tagacataat       60

agcaacagac atacaaacta aagaattaca aaaacaaatt acaaaaattc aaaatttt        118


<210>  9
<211>  330
<212>  DNA
<213>  SV40


<220>
<221>  misc_feature
<222>  (1)..(330)
<223>  SV40 Promoter Site

<400>  9
gtgtgtcagt tagggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc       60

atgcatctca attagtcagc aaccaggtgt ggaaagtccc caggctcccc agcaggcaga      120

agtatgcaaa gcatgcatct caattagtca gcaaccatag tcccgcccct aactccgccc      180

atcccgcccc taactccgcc cagttccgcc cattctccgc cccatggctg actaattttt      240

tttatttatg cagaggccga ggccgcctcg gcctctgagc tattccagaa gtagtgagga      300

ggcttttttg gaggcctagg cttttgcaaa                                       330


<210>  10
<211>  199
<212>  PRT
<213>  Streptomyces alboniger


<220>
<221>  MISC_FEATURE
<222>  (1)..(199)
<223>  Streptomyces alboniger N-acetyltransferase

<400>  10

Met Thr Glu Tyr Lys Pro Thr Val Arg Leu Ala Thr Arg Asp Asp Val 
1               5                   10                  15      


Pro Arg Ala Val Arg Thr Leu Ala Ala Ala Phe Ala Asp Tyr Pro Ala 
            20                  25                  30          


Thr Arg His Thr Val Asp Pro Asp Arg His Ile Glu Arg Val Thr Glu 
        35                  40                  45              


Leu Gln Glu Leu Phe Leu Thr Arg Val Gly Leu Asp Ile Gly Lys Val 
    50                  55                  60                  


Trp Val Ala Asp Asp Gly Ala Ala Val Ala Val Trp Thr Thr Pro Glu 
65                  70                  75                  80  


Ser Val Glu Ala Gly Ala Val Phe Ala Glu Ile Gly Pro Arg Met Ala 
                85                  90                  95      


Glu Leu Ser Gly Ser Arg Leu Ala Ala Gln Gln Gln Met Glu Gly Leu 
            100                 105                 110         


Leu Ala Pro His Arg Pro Lys Glu Pro Ala Trp Phe Leu Ala Thr Val 
        115                 120                 125             


Gly Val Ser Pro Asp His Gln Gly Lys Gly Leu Gly Ser Ala Val Val 
    130                 135                 140                 


Leu Pro Gly Val Glu Ala Ala Glu Arg Ala Gly Val Pro Ala Phe Leu 
145                 150                 155                 160 


Glu Thr Ser Ala Pro Arg Asn Leu Pro Phe Tyr Glu Arg Leu Gly Phe 
                165                 170                 175     


Thr Val Thr Ala Asp Val Glu Val Pro Glu Gly Pro Arg Thr Trp Cys 
            180                 185                 190         


Met Thr Arg Lys Pro Gly Ala 
        195                 


<210>  11
<211>  600
<212>  DNA
<213>  Streptomyces alboniger


<220>
<221>  misc_feature
<222>  (1)..(600)
<223>  Polynucleotide Encoding Streptomyces alboniger 
       N-acetyltransferase

<400>  11
atgaccgagt acaagcccac ggtgcgcctc gccacccgcg acgacgtccc ccgggcagta       60

cgcaccctcg ccgccgcgtt cgccgactac cccgccacgc gccacaccgt cgatccagac      120

cgccacatcg agcgggtcac cgagctgcaa gaactcttcc tcacgcgcgt cgggctcgac      180

atcggcaagg tgtgggtcgc ggacgacggc gccgcggtgg cggtctggac cacgccggag      240

agcgtcgaag cgggggcggt gttcgccgag atcggcccgc gcatggccga gttgagcggt      300

tcccggctgg ccgcgcagca acagatggaa ggcctcctgg cgccgcaccg gcccaaggag      360

cccgcgtggt tcctggccac cgtcggcgtc tcgcccgacc accagggcaa gggtctgggc      420

agcgccgtcg tgctccccgg agtggaggcg gccgagcgcg ccggggtgcc cgccttcctg      480

gagacctccg cgccccgcaa cctccccttc tacgagcggc tcggcttcac cgtcaccgcc      540

gacgtcgagg tgcccgaagg accgcgcacc tggtgcatga cccgcaagcc cggtgcctga      600


<210>  12
<211>  19
<212>  DNA
<213>  Bacteriophage T7


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  Bacteriophage T7 Promoter

<400>  12
taatacgact cactatagg                                                    19


<210>  13
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Myc-FLAG Tag

<400>  13

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Asn Asp Ile Leu 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Lys Val 
            20                  25  


<210>  14
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Myc-FLAG Tag

<400>  14
gagcagaaac tcatctcaga agaggatctg gcagcaaatg atatcctgga ttacaaggat       60

gacgacgata aggtt                                                        75


<210>  15
<211>  34
<212>  DNA
<213>  Bacteriophage P1


<220>
<221>  misc_feature
<222>  (1)..(34)
<223>  Bacteriophage P1 LoxP Site

<400>  15
ataacttcgt atagcataca ttatacgaag ttat                                   34


<210>  16
<211>  589
<212>  DNA
<213>  Woodchuck Hepatitis Virus


<220>
<221>  misc_feature
<222>  (1)..(589)
<223>  Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element
       (WPRE)

<400>  16
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttgc tgtctcttta tgaggagttg      180

tggcccgttg tcaggcaacg tggcgtggtg tgcactgtgt ttgctgacgc aacccccact      240

ggttggggca ttgccaccac ctgtcagctc ctttccggga ctttcgcttt ccccctccct      300

attgccacgg cggaactcat cgccgcctgc cttgcccgct gctggacagg ggctcggctg      360

ttgggcactg acaattccgt ggtgttgtcg gggaaatcat cgtcctttcc ttggctgctc      420

gcctgtgttg ccacctggat tctgcgcggg acgtccttct gctacgtccc ttcggccctc      480

aatccagcgg accttccttc ccgcggcctg ctgccggctc tgcggcctct tccgcgtctt      540

cgccttcgcc ctcagacgag tcggatctcc ctttgggccg cctccccgc                  589


<210>  17
<211>  12
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  Factor Xa Cleavage Site

<400>  17
tcggccctca at                                                           12


<210>  18
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  KS Primer Binding Site

<400>  18
cgaggtcgac ggtatcg                                                      17


<210>  19
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ColE1/pMB1/pBR322/pUC Origin of Replication

<400>  19
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  20
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant ColE1/pMB1/pBR322/pUC Origin of Replication

<400>  20
ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac caccgctacc       60

agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg taactggctt      120

cagcagagcg cagataccaa atactgtcct tctagtgtag ccgtagttag gccaccactt      180

caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac cagtggctgc      240

tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt taccggataa      300

ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg agcgaacgac      360

ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc ttcccgaagg      420

gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc gcacgaggga      480

gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc acctctgact      540

tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaa                  589


<210>  21
<211>  286
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (1)..(286)
<223>  AmpR Antibiotic Resistance Determinant

<400>  21

Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 
1               5                   10                  15      


Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 
            20                  25                  30          


Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 
        35                  40                  45              


Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 
    50                  55                  60                  


Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 
65                  70                  75                  80  


Arg Ile Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 
                85                  90                  95      


Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 
            100                 105                 110         


Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 
        115                 120                 125             


Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 
    130                 135                 140                 


Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 
145                 150                 155                 160 


Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 
                165                 170                 175     


Asp Thr Thr Met Pro Val Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 
            180                 185                 190         


Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 
        195                 200                 205             


Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 
    210                 215                 220                 


Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 
                245                 250                 255     


Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 
            260                 265                 270         


Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        275                 280                 285     


<210>  22
<211>  858
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(858)
<223>  Polynucleotide Encoding AmpR Antibiotic Resistance Determinant

<400>  22
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc      240

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattgg                                                    858


<210>  23
<211>  286
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<222>  (1)..(286)
<223>  Variant AmpR Antibiotic Resistance Determinant

<400>  23

Met Ser Ile Gln His Phe Arg Val Ala Leu Ile Pro Phe Phe Ala Ala 
1               5                   10                  15      


Phe Cys Leu Pro Val Phe Ala His Pro Glu Thr Leu Val Lys Val Lys 
            20                  25                  30          


Asp Ala Glu Asp Gln Leu Gly Ala Arg Val Gly Tyr Ile Glu Leu Asp 
        35                  40                  45              


Leu Asn Ser Gly Lys Ile Leu Glu Ser Phe Arg Pro Glu Glu Arg Phe 
    50                  55                  60                  


Pro Met Met Ser Thr Phe Lys Val Leu Leu Cys Gly Ala Val Leu Ser 
65                  70                  75                  80  


Arg Val Asp Ala Gly Gln Glu Gln Leu Gly Arg Arg Ile His Tyr Ser 
                85                  90                  95      


Gln Asn Asp Leu Val Glu Tyr Ser Pro Val Thr Glu Lys His Leu Thr 
            100                 105                 110         


Asp Gly Met Thr Val Arg Glu Leu Cys Ser Ala Ala Ile Thr Met Ser 
        115                 120                 125             


Asp Asn Thr Ala Ala Asn Leu Leu Leu Thr Thr Ile Gly Gly Pro Lys 
    130                 135                 140                 


Glu Leu Thr Ala Phe Leu His Asn Met Gly Asp His Val Thr Arg Leu 
145                 150                 155                 160 


Asp Arg Trp Glu Pro Glu Leu Asn Glu Ala Ile Pro Asn Asp Glu Arg 
                165                 170                 175     


Asp Thr Thr Met Pro Ala Ala Met Ala Thr Thr Leu Arg Lys Leu Leu 
            180                 185                 190         


Thr Gly Glu Leu Leu Thr Leu Ala Ser Arg Gln Gln Leu Ile Asp Trp 
        195                 200                 205             


Met Glu Ala Asp Lys Val Ala Gly Pro Leu Leu Arg Ser Ala Leu Pro 
    210                 215                 220                 


Ala Gly Trp Phe Ile Ala Asp Lys Ser Gly Ala Gly Glu Arg Gly Ser 
225                 230                 235                 240 


Arg Gly Ile Ile Ala Ala Leu Gly Pro Asp Gly Lys Pro Ser Arg Ile 
                245                 250                 255     


Val Val Ile Tyr Thr Thr Gly Ser Gln Ala Thr Met Asp Glu Arg Asn 
            260                 265                 270         


Arg Gln Ile Ala Glu Ile Gly Ala Ser Leu Ile Lys His Trp 
        275                 280                 285     


<210>  24
<211>  858
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(861)
<223>  Polynucleotide Encoding Varinat AmpR Antibiotic Resistance 
       Determinant

<400>  24
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc      240

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattgg                                                    858


<210>  25
<211>  105
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(105)
<223>  AmpR Promoter-Containing Polynucleotide

<400>  25
cgcgggaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga       60

caataaccct gataaatgct tcaataatat tgaaaaagga agagt                      105


<210>  26
<211>  105
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(105)
<223>  Variant AmpR Promoter-Containing Polynucleotide

<400>  26
cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc gctcatgaga       60

caataaccct gataaatgct tcaataatat tgaaaaagga agagt                      105


<210>  27
<211>  7705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLenti-SV40-puro Vector

<400>  27
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat cgcgttgaca      240

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagcgcg ttttgcctgt actgggtctc      840

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      900

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      960

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtggcg     1020

cccgaacagg gacttgaaag cgaaagggaa accagaggag ctctctcgac gcaggactcg     1080

gcttgctgaa gcgcgcacgg caagaggcga ggggcggcga ctggtgagta cgccaaaaat     1140

tttgactagc ggaggctaga aggagagaga tgggtgcgag agcgtcagta ttaagcgggg     1200

gagaattaga tcgcgatggg aaaaaattcg gttaaggcca gggggaaaga aaaaatataa     1260

attaaaacat atagtatggg caagcaggga gctagaacga ttcgcagtta atcctggcct     1320

gttagaaaca tcagaaggct gtagacaaat actgggacag ctacaaccat cccttcagac     1380

aggatcagaa gaacttagat cattatataa tacagtagca accctctatt gtgtgcatca     1440

aaggatagag ataaaagaca ccaaggaagc tttagacaag atagaggaag agcaaaacaa     1500

aagtaagacc accgcacagc aagcggccgg ccgctgatct tcagacctgg aggaggagat     1560

atgagggaca attggagaag tgaattatat aaatataaag tagtaaaaat tgaaccatta     1620

ggagtagcac ccaccaaggc aaagagaaga gtggtgcaga gagaaaaaag agcagtggga     1680

ataggagctt tgttccttgg gttcttggga gcagcaggaa gcactatggg cgcagcgtca     1740

atgacgctga cggtacaggc cagacaatta ttgtctggta tagtgcagca gcagaacaat     1800

ttgctgaggg ctattgaggc gcaacagcat ctgttgcaac tcacagtctg gggcatcaag     1860

cagctccagg caagaatcct ggctgtggaa agatacctaa aggatcaaca gctcctgggg     1920

atttggggtt gctctggaaa actcatttgc accactgctg tgccttggaa tgctagttgg     1980

agtaataaat ctctggaaca gatttggaat cacacgacct ggatggagtg ggacagagaa     2040

attaacaatt acacaagctt aatacactcc ttaattgaag aatcgcaaaa ccagcaagaa     2100

aagaatgaac aagaattatt ggaattagat aaatgggcaa gtttgtggaa ttggtttaac     2160

ataacaaatt ggctgtggta tataaaatta ttcataatga tagtaggagg cttggtaggt     2220

ttaagaatag tttttgctgt actttctata gtgaatagag ttaggcaggg atattcacca     2280

ttatcgtttc agacccacct cccaaccccg aggggacccg acaggcccga aggaatagaa     2340

gaagaaggtg gagagagaga cagagacaga tccattcgat tagtgaacgg atcggcactg     2400

cgtgcgccaa ttctgcagac aaatggcagt attcatccac aattttaaaa gaaaaggggg     2460

gattgggggg tacagtgcag gggaaagaat agtagacata atagcaacag acatacaaac     2520

taaagaatta caaaaacaaa ttacaaaaat tcaaaatttt cgggtttatt acagggacag     2580

cagagatcca gtttggttag taccgggccc gctctagaat gtgtgtcagt tagggtgtgg     2640

aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc     2700

aaccaggtgt ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct     2760

caattagtca gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc     2820

cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg cagaggccga     2880

ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg     2940

cttttgcaaa aagctcccgg gagcttgtat atccattttc ggatctgatc aagagacacg     3000

tacgaccatg accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtcccccg     3060

ggcagtacgc accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga     3120

tccagaccgc cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg     3180

gctcgacatc ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac     3240

gccggagagc gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt     3300

gagcggttcc cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc     3360

caaggagccc gcgtggttcc tggccaccgt cggcgtctcg cccgaccacc agggcaaggg     3420

tctgggcagc gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc     3480

cttcctggag acctccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt     3540

caccgccgac gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg     3600

tgcctgattt ctagacatgt ccaatatgac cgccatgttg acattgatta ttgactagtt     3660

attaatagta atcaattacg gggtcattag ttcatagccc atatatggag ttccgcgtta     3720

cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc ccattgacgt     3780

caataatgac gtatgttccc atagtaacgc caatagggac tttccattga cgtcaatggg     3840

tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat atgccaagtc     3900

cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc cagtacatga     3960

ccttacggga ctttcctact tggcagtaca tctacgtatt agtcatcgct attaccatgg     4020

tgatgcggtt ttggcagtac accaatgggc gtggatagcg gtttgactca cggggatttc     4080

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact     4140

ttccaaaatg tcgtaataac cccgccccgt tgacgcaaat gggcggtagg cgtgtacggt     4200

gggaggtcta tataagcaga gctcgtttag tgaaccgtca gaattttgta atacgactca     4260

ctatagggcg gccgggaatt cgtcgactgg atccggtacc gaggagatct gccgccgcga     4320

tcgccggcgc gccagatctc aagcttaact agctagcgga ccgacgcgta cgcggccgct     4380

cgagcagaaa ctcatctcag aagaggatct ggcagcaaat gatatcctgg attacaagga     4440

tgacgacgat aaggtttaaa cggccggccg cggtctgtac aagtaggatt cgtcgaggga     4500

cctaataact tcgtatagca tacattatac gaagttatac atgtttaagg gttccggttc     4560

cactaggtac aattcgatat caagcttatc gataatcaac ctctggatta caaaatttgt     4620

gaaagattga ctggtattct taactatgtt gctcctttta cgctatgtgg atacgctgct     4680

ttaatgcctt tgtatcatgc tattgcttcc cgtatggctt tcattttctc ctccttgtat     4740

aaatcctggt tgctgtctct ttatgaggag ttgtggcccg ttgtcaggca acgtggcgtg     4800

gtgtgcactg tgtttgctga cgcaaccccc actggttggg gcattgccac cacctgtcag     4860

ctcctttccg ggactttcgc tttccccctc cctattgcca cggcggaact catcgccgcc     4920

tgccttgccc gctgctggac aggggctcgg ctgttgggca ctgacaattc cgtggtgttg     4980

tcggggaaat catcgtcctt tccttggctg ctcgcctgtg ttgccacctg gattctgcgc     5040

gggacgtcct tctgctacgt cccttcggcc ctcaatccag cggaccttcc ttcccgcggc     5100

ctgctgccgg ctctgcggcc tcttccgcgt cttcgccttc gccctcagac gagtcggatc     5160

tccctttggg ccgcctcccc gcatcgatac cgtcgacctc gatcgagacc tagaaaaaca     5220

tggagcaatc acaagtagca atacagcagc taccaatgct gattgtgcct ggctagaagc     5280

acaagaggag gaggaggtgg gttttccagt cacacctcag gtacctttaa gaccaatgac     5340

ttacaaggca gctgtagatc ttagccactt tttaaaagaa aaggggggac tggaagggct     5400

aattcactcc caacgaagac aagatatcct tgatctgtgg atctaccaca cacaaggcta     5460

cttccctgat tggcagaact acacaccagg gccagggatc agatatccac tgacctttgg     5520

atggtgctac aagctagtac cagttgagca agagaaggta gaagaagcca atgaaggaga     5580

gaacacccgc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg agagagaagt     5640

attagagtgg aggtttgaca gccgcctagc atttcatcac atggcccgag agctgcatcc     5700

ggactgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact     5760

agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc     5820

ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa     5880

aatctctagc agcatgtgag caaaaggcca gcaaaaggcc aggaaccgta aaaaggccgc     5940

gttgctggcg tttttccata ggctccgccc ccctgacgag catcacaaaa atcgacgctc     6000

aagtcagagg tggcgaaacc cgacaggact ataaagatac caggcgtttc cccctggaag     6060

ctccctcgtg cgctctcctg ttccgaccct gccgcttacc ggatacctgt ccgcctttct     6120

cccttcggga agcgtggcgc tttctcatag ctcacgctgt aggtatctca gttcggtgta     6180

ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc gttcagcccg accgctgcgc     6240

cttatccggt aactatcgtc ttgagtccaa cccggtaaga cacgacttat cgccactggc     6300

agcagccact ggtaacagga ttagcagagc gaggtatgta ggcggtgcta cagagttctt     6360

gaagtggtgg cctaactacg gctacactag aagaacagta tttggtatct gcgctctgct     6420

gaagccagtt accttcggaa aaagagttgg tagctcttga tccggcaaac aaaccaccgc     6480

tggtagcggt ggtttttttg tttgcaagca gcagattacg cgcagaaaaa aaggatctca     6540

agaagatcct ttgatctttt ctacggggtc tgacgctcag tggaacgaaa actcacgtta     6600

agggattttg gtcatgagat tatcaaaaag gatcttcacc tagatccttt taaattaaaa     6660

atgaagtttt aaatcaatct aaagtatata tgagtaaact tggtctgaca gttaccaatg     6720

cttaatcagt gaggcaccta tctcagcgat ctgtctattt cgttcatcca tagttgcctg     6780

actccccgtc gtgtagataa ctacgatacg ggagggctta ccatctggcc ccagtgctgc     6840

aatgataccg cgagacccac gctcaccggc tccagattta tcagcaataa accagccagc     6900

cggaagggcc gagcgcagaa gtggtcctgc aactttatcc gcctccatcc agtctattaa     6960

ttgttgccgg gaagctagag taagtagttc gccagttaat agtttgcgca acgttgttgc     7020

cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt atggcttcat tcagctccgg     7080

ttcccaacga tcaaggcgag ttacatgatc ccccatgttg tgcaaaaaag cggttagctc     7140

cttcggtcct ccgatcgttg tcagaagtaa gttggccgca gtgttatcac tcatggttat     7200

ggcagcactg cataattctc ttactgtcat gccatccgta agatgctttt ctgtgactgg     7260

tgagtactca accaagtcat tctgagaata gtgtatgcgg cgaccgagtt gctcttgccc     7320

ggcgtcaata cgggataata ccgcgccaca tagcagaact ttaaaagtgc tcatcattgg     7380

aaaacgttct tcggggcgaa aactctcaag gatcttaccg ctgttgagat ccagttcgat     7440

gtaacccact cgtgcaccca actgatcttc agcatctttt actttcacca gcgtttctgg     7500

gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga ataagggcga cacggaaatg     7560

ttgaatactc atactcttcc tttttcaata ttattgaagc atttatcagg gttattgtct     7620

catgagcgga tacatatttg aatgtattta gaaaaataaa caaatagggg tcccgcgcac     7680

atttccccga aaagtgccac ctgac                                           7705


<210>  28
<211>  7701
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLenti-SV40-puro (-att) Vector

<400>  28
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat cgcgttgaca      240

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagcgcg ttttgcctgt actgggtctc      840

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      900

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      960

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct aggtggcgcc     1020

cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc     1080

ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt     1140

tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga     1200

gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat     1260

taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt     1320

tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag     1380

gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa     1440

ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa     1500

gtaagaccac cgcacagcaa gcggccggcc gctgatcttc agacctggag gaggagatat     1560

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1620

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1680

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat     1740

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1800

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1860

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1920

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1980

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     2040

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     2100

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     2160

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     2220

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     2280

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     2340

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat cggcactgcg     2400

tgcgccaatt ctgcagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga     2460

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta     2520

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca     2580

gagatccagt ttggttagta ccgggcccgc tctagaatgt gtgtcagtta gggtgtggaa     2640

agtccccagg ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa     2700

ccaggtgtgg aaagtcccca ggctccccag caggcagaag tatgcaaagc atgcatctca     2760

attagtcagc aaccatagtc ccgcccctaa ctccgcccat cccgccccta actccgccca     2820

gttccgccca ttctccgccc catggctgac taattttttt tatttatgca gaggccgagg     2880

ccgcctcggc ctctgagcta ttccagaagt agtgaggagg cttttttgga ggcctaggct     2940

tttgcaaaaa gctcccggga gcttgtatat ccattttcgg atctgatcaa gagacacgta     3000

cgaccatgac cgagtacaag cccacggtgc gcctcgccac ccgcgacgac gtcccccggg     3060

cagtacgcac cctcgccgcc gcgttcgccg actaccccgc cacgcgccac accgtcgatc     3120

cagaccgcca catcgagcgg gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc     3180

tcgacatcgg caaggtgtgg gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc     3240

cggagagcgt cgaagcgggg gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga     3300

gcggttcccg gctggccgcg cagcaacaga tggaaggcct cctggcgccg caccggccca     3360

aggagcccgc gtggttcctg gccaccgtcg gcgtctcgcc cgaccaccag ggcaagggtc     3420

tgggcagcgc cgtcgtgctc cccggagtgg aggcggccga gcgcgccggg gtgcccgcct     3480

tcctggagac ctccgcgccc cgcaacctcc ccttctacga gcggctcggc ttcaccgtca     3540

ccgccgacgt cgaggtgccc gaaggaccgc gcacctggtg catgacccgc aagcccggtg     3600

cctgatttct agacatgtcc aatatgaccg ccatgttgac attgattatt gactagttat     3660

taatagtaat caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca     3720

taacttacgg taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca     3780

ataatgacgt atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg     3840

gagtatttac ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtccg     3900

ccccctattg acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc     3960

ttacgggact ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg     4020

atgcggtttt ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca     4080

agtctccacc ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt     4140

ccaaaatgtc gtaataaccc cgccccgttg acgcaaatgg gcggtaggcg tgtacggtgg     4200

gaggtctata taagcagagc tcgtttagtg aaccgtcaga attttgtaat acgactcact     4260

atagggcggc cgggaattcg tcgactggat ccggtaccga ggagatctgc cgccgcgatc     4320

gccggcgcgc cagatctcaa gcttaactag ctagcggacc gacgcgtacg cggccgctcg     4380

agcagaaact catctcagaa gaggatctgg cagcaaatga tatcctggat tacaaggatg     4440

acgacgataa ggtttaaacg gccggccgcg gtctgtacaa gtaggattcg tcgagggacc     4500

taataacttc gtatagcata cattatacga agttatacat gtttaagggt tccggttcca     4560

ctaggtacaa ttcgatatca agcttatcga taatcaacct ctggattaca aaatttgtga     4620

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     4680

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     4740

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     4800

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     4860

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     4920

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     4980

ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg     5040

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     5100

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     5160

cctttgggcc gcctccccgc atcgataccg tcgacctcga tcgagaccta gaaaaacatg     5220

gagcaatcac aagtagcaat acagcagcta ccaatgctga ttgtgcctgg ctagaagcac     5280

aagaggagga ggaggtgggt tttccagtca cacctcaggt acctttaaga ccaatgactt     5340

acaaggcagc tgtagatctt agccactttt taaaagaaaa ggggggacga agggctaatt     5400

cactcccaac gaagacaaga tctgcttgat ctgtggatct accacacaca aggctacttc     5460

cctgattggc agaactacac accagggcca gggatcagat atccactgac ctttggatgg     5520

tgctacaagc tagtaccagt tgagcaagag aaggtagaag aagccaatga aggagagaac     5580

acccgcttgt tacaccctgt gagcctgcat gggatggatg acccggagag agaagtatta     5640

gagtggaggt ttgacagccg cctagcattt catcacatgg cccgagagct gcatccggac     5700

tgtactgggt ctctctggtt agaccagatc tgagcctggg agctctctgg ctaactaggg     5760

aacccactgc ttaagcctca ataaagcttg ccttgagtgc ttcaagtagt gtgtgcccgt     5820

ctgttgtgtg actctggtaa ctagagatcc ctcagaccct tttagtcagt gtggaaaatc     5880

tctagcagca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg     5940

ctggcgtttt tccataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt     6000

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc     6060

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct     6120

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc     6180

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta     6240

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca     6300

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag     6360

tggtggccta actacggcta cactagaaga acagtatttg gtatctgcgc tctgctgaag     6420

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     6480

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     6540

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     6600

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     6660

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     6720

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     6780

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     6840

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     6900

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     6960

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttgccatt     7020

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     7080

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     7140

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     7200

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     7260

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     7320

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     7380

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     7440

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     7500

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     7560

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     7620

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggtccc gcgcacattt     7680

ccccgaaaag tgccacctga c                                               7701


<210>  29
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated Variant of Human Cytomegalovirus (CMV) Immediate Early 
       Enhancer Site

<400>  29
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catg                                                                   304


<210>  30
<211>  304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Truncated Variant of Variant Human Cytomegalovirus (CMV) 
       Immediate Early Enhancer Site

<400>  30
cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt       60

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      120

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      180

aagtccgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      240

catgacctta cgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      300

catg                                                                   304


<210>  31
<211>  204
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Human Cytomegalovirus (CMV) Immediate Early Enhancer Site

<400>  31
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  32
<211>  200
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Human Cytomegalovirus (CMV) Immediate Early Enhancer Site

<400>  32
gtgatgcggt tttggcagta caccaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag                                                  200


<210>  33
<211>  500
<212>  PRT
<213>  HIV-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(500)
<223>  HIV-1 GAG Protein

<400>  33

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Asn Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Ile Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Thr Ala Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Tyr Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Ser Gly Val Glu Thr Thr Thr Pro Pro Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Leu Tyr Pro Leu Thr Ser Leu Arg Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln 
            500 


<210>  34
<211>  1500
<212>  DNA
<213>  HIV-1


<220>
<221>  misc_feature
<222>  (1)..(1500)
<223>  Polynucleotide Encoding HIV-1 GAG Protein

<400>  34
atgggtgcga gagcgtcagt attaagcggg ggagaattag atcgatggga aaaaattcgg       60

ttaaggccag ggggaaagaa aaaatataaa ttaaaacata tagtatgggc aagcagggag      120

ctagaacgat tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata      180

ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat      240

acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac caaggaagct      300

ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa aagcacagca agcagcagct      360

gacacaggac acagcaatca ggtcagccaa aattacccta tagtgcagaa catccagggg      420

caaatggtac atcaggccat atcacctaga actttaaatg catgggtaaa agtagtagaa      480

gagaaggctt tcagcccaga agtgataccc atgttttcag cattatcaga aggagccacc      540

ccacaagatt taaacaccat gctaaacaca gtggggggac atcaagcagc catgcaaatg      600

ttaaaagaga ccatcaatga ggaagctgca gaatgggata gagtgcatcc agtgcatgca      660

gggcctattg caccaggcca gatgagagaa ccaaggggaa gtgacatagc aggaactact      720

agtacccttc aggaacaaat aggatggatg acaaataatc cacctatccc agtaggagaa      780

atttataaaa gatggataat cctgggatta aataaaatag taagaatgta tagccctacc      840

agcattctgg acataagaca aggaccaaaa gaacccttta gagactatgt agaccggttc      900

tataaaactc taagagccga gcaagcttca caggaggtaa aaaattggat gacagaaacc      960

ttgttggtcc aaaatgcgaa cccagattgt aagactattt taaaagcatt gggaccagcg     1020

gctacactag aagaaatgat gacagcatgt cagggagtag gaggacccgg ccataaggca     1080

agagttttgg ctgaagcaat gagccaagta acaaattcag ctaccataat gatgcagaga     1140

ggcaatttta ggaaccaaag aaagattgtt aagtgtttca attgtggcaa agaagggcac     1200

acagccagaa attgcagggc ccctaggaaa aagggctgtt ggaaatgtgg aaaggaagga     1260

caccaaatga aagattgtac tgagagacag gctaattttt tagggaagat ctggccttcc     1320

tacaagggaa ggccagggaa ttttcttcag agcagaccag agccaacagc cccaccagaa     1380

gagagcttca ggtctggggt agagacaaca actccccctc agaagcagga gccgatagac     1440

aaggaactgt atcctttaac ttccctcaga tcactctttg gcaacgaccc ctcgtcacaa     1500


<210>  35
<211>  912
<212>  PRT
<213>  HIV-1


<220>
<221>  MISC_FEATURE
<222>  (1)..(912)
<223>  HIV-1 POL Protein

<400>  35

Met Ser Leu Pro Gly Arg Trp Lys Pro Lys Met Ile Gly Gly Ile Gly 
1               5                   10                  15      


Gly Phe Ile Lys Val Arg Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys 
            20                  25                  30          


Gly His Lys Ala Ile Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn 
        35                  40                  45              


Ile Ile Gly Arg Asn Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe 
    50                  55                  60                  


Pro Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met 
65                  70                  75                  80  


Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys 
                85                  90                  95      


Ala Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser 
            100                 105                 110         


Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys 
        115                 120                 125             


Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu 
    130                 135                 140                 


Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His 
145                 150                 155                 160 


Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly 
                165                 170                 175     


Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr 
            180                 185                 190         


Ala Phe Thr Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr 
        195                 200                 205             


Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe 
    210                 215                 220                 


Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro 
225                 230                 235                 240 


Asp Ile Val Ile Tyr Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp 
                245                 250                 255     


Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His 
            260                 265                 270         


Leu Leu Arg Trp Gly Leu Thr Thr Pro Asp Lys Lys His Gln Lys Glu 
        275                 280                 285             


Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr 
    290                 295                 300                 


Val Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp 
305                 310                 315                 320 


Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Pro 
                325                 330                 335     


Gly Ile Lys Val Arg Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala 
            340                 345                 350         


Leu Thr Glu Val Ile Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala 
        355                 360                 365             


Glu Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp 
    370                 375                 380                 


Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln 
385                 390                 395                 400 


Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly 
                405                 410                 415     


Lys Tyr Ala Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu 
            420                 425                 430         


Thr Glu Ala Val Gln Lys Ile Thr Thr Glu Ser Ile Val Ile Trp Gly 
        435                 440                 445             


Lys Thr Pro Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Thr 
    450                 455                 460                 


Trp Trp Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe 
465                 470                 475                 480 


Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu 
                485                 490                 495     


Pro Ile Val Gly Ala Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg 
            500                 505                 510         


Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asn Arg Gly Arg Gln 
        515                 520                 525             


Lys Val Val Thr Leu Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln 
    530                 535                 540                 


Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val 
545                 550                 555                 560 


Thr Asp Ser Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Gln 
                565                 570                 575     


Ser Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Gln Leu Ile Lys Lys 
            580                 585                 590         


Glu Lys Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly 
        595                 600                 605             


Asn Glu Gln Val Asp Lys Leu Val Ser Ala Gly Ile Arg Lys Val Leu 
    610                 615                 620                 


Phe Leu Asp Gly Ile Asp Lys Ala Gln Asp Glu His Glu Lys Tyr His 
625                 630                 635                 640 


Ser Asn Trp Arg Ala Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val 
                645                 650                 655     


Ala Lys Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu 
            660                 665                 670         


Ala Met His Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp 
        675                 680                 685             


Cys Thr His Leu Glu Gly Lys Val Ile Leu Val Ala Val His Val Ala 
    690                 695                 700                 


Ser Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu 
705                 710                 715                 720 


Thr Ala Tyr Phe Leu Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr 
                725                 730                 735     


Ile His Thr Asp Asn Gly Ser Asn Phe Thr Ser Ala Thr Val Lys Ala 
            740                 745                 750         


Ala Cys Trp Trp Ala Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn 
        755                 760                 765             


Pro Gln Ser Gln Gly Val Val Glu Ser Met Asn Lys Glu Leu Lys Lys 
    770                 775                 780                 


Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr Ala Val 
785                 790                 795                 800 


Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly 
                805                 810                 815     


Gly Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile 
            820                 825                 830         


Gln Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg 
        835                 840                 845             


Val Tyr Tyr Arg Asp Ser Arg Asn Pro Leu Trp Lys Gly Pro Ala Lys 
    850                 855                 860                 


Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp 
865                 870                 875                 880 


Ile Lys Val Val Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly 
                885                 890                 895     


Lys Gln Met Ala Gly Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp 
            900                 905                 910         


<210>  36
<211>  2736
<212>  DNA
<213>  HIV-1


<220>
<221>  misc_feature
<222>  (1)..(2736)
<223>  Polynucleotide Encoding HIV-1 POL Protein

<400>  36
atgagtttgc caggaagatg gaaaccaaaa atgatagggg gaattggagg ttttatcaaa       60

gtaagacagt atgatcagat actcatagaa atctgtggac ataaagctat aggtacagta      120

ttagtaggac ctacacctgt caacataatt ggaagaaatc tgttgactca gattggttgc      180

actttaaatt ttcccattag ccctattgag actgtaccag taaaattaaa gccaggaatg      240

gatggcccaa aagttaaaca atggccattg acagaagaaa aaataaaagc attagtagaa      300

atttgtacag agatggaaaa ggaagggaaa atttcaaaaa ttgggcctga aaatccatac      360

aatactccag tatttgccat aaagaaaaaa gacagtacta aatggagaaa attagtagat      420

ttcagagaac ttaataagag aactcaagac ttctgggaag ttcaattagg aataccacat      480

cccgcagggt taaaaaagaa aaaatcagta acagtactgg atgtgggtga tgcatatttt      540

tcagttccct tagatgaaga cttcaggaaa tatactgcat ttaccatacc tagtataaac      600

aatgagacac cagggattag atatcagtac aatgtgcttc cacagggatg gaaaggatca      660

ccagcaatat tccaaagtag catgacaaaa atcttagagc cttttagaaa acaaaatcca      720

gacatagtta tctatcaata catggatgat ttgtatgtag gatctgactt agaaataggg      780

cagcatagaa caaaaataga ggagctgaga caacatctgt tgaggtgggg acttaccaca      840

ccagacaaaa aacatcagaa agaacctcca ttcctttgga tgggttatga actccatcct      900

gataaatgga cagtacagcc tatagtgctg ccagaaaaag acagctggac tgtcaatgac      960

atacagaagt tagtggggaa attgaattgg gcaagtcaga tttacccagg gattaaagta     1020

aggcaattat gtaaactcct tagaggaacc aaagcactaa cagaagtaat accactaaca     1080

gaagaagcag agctagaact ggcagaaaac agagagattc taaaagaacc agtacatgga     1140

gtgtattatg acccatcaaa agacttaata gcagaaatac agaagcaggg gcaaggccaa     1200

tggacatatc aaatttatca agagccattt aaaaatctga aaacaggaaa atatgcaaga     1260

atgaggggtg cccacactaa tgatgtaaaa caattaacag aggcagtgca aaaaataacc     1320

acagaaagca tagtaatatg gggaaagact cctaaattta aactgcccat acaaaaggaa     1380

acatgggaaa catggtggac agagtattgg caagccacct ggattcctga gtgggagttt     1440

gttaataccc ctcctttagt gaaattatgg taccagttag agaaagaacc catagtagga     1500

gcagaaacct tctatgtaga tggggcagct aacagggaga ctaaattagg aaaagcagga     1560

tatgttacta atagaggaag acaaaaagtt gtcaccctaa ctgacacaac aaatcagaag     1620

actgagttac aagcaattta tctagctttg caggattcgg gattagaagt aaacatagta     1680

acagactcac aatatgcatt aggaatcatt caagcacaac cagatcaaag tgaatcagag     1740

ttagtcaatc aaataataga gcagttaata aaaaaggaaa aggtctatct ggcatgggta     1800

ccagcacaca aaggaattgg aggaaatgaa caagtagata aattagtcag tgctggaatc     1860

aggaaagtac tatttttaga tggaatagat aaggcccaag atgaacatga gaaatatcac     1920

agtaattgga gagcaatggc tagtgatttt aacctgccac ctgtagtagc aaaagaaata     1980

gtagccagct gtgataaatg tcagctaaaa ggagaagcca tgcatggaca agtagactgt     2040

agtccaggaa tatggcaact agattgtaca catttagaag gaaaagttat cctggtagca     2100

gttcatgtag ccagtggata tatagaagca gaagttattc cagcagaaac agggcaggaa     2160

acagcatatt ttcttttaaa attagcagga agatggccag taaaaacaat acatacagac     2220

aatggcagca atttcaccag tgctacggtt aaggccgcct gttggtgggc gggaatcaag     2280

caggaatttg gaattcccta caatccccaa agtcaaggag tagtagaatc tatgaataaa     2340

gaattaaaga aaattatagg acaggtaaga gatcaggctg aacatcttaa gacagcagta     2400

caaatggcag tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca     2460

ggggaaagaa tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa     2520

attacaaaaa ttcaaaattt tcgggtttat tacagggaca gcagaaatcc actttggaaa     2580

ggaccagcaa agctcctctg gaaaggtgaa ggggcagtag taatacaaga taatagtgac     2640

ataaaagtag tgccaagaag aaaagcaaag atcattaggg attatggaaa acagatggca     2700

ggtgatgatt gtgtggcaag tagacaggat gaggat                               2736


<210>  37
<211>  912
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant HIV-1 POL Protein Comprising D249V, D250V and D688V 
       Substitutions

<400>  37

Met Ser Leu Pro Gly Arg Trp Lys Pro Lys Met Ile Gly Gly Ile Gly 
1               5                   10                  15      


Gly Phe Ile Lys Val Arg Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys 
            20                  25                  30          


Gly His Lys Ala Ile Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn 
        35                  40                  45              


Ile Ile Gly Arg Asn Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe 
    50                  55                  60                  


Pro Ile Ser Pro Ile Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met 
65                  70                  75                  80  


Asp Gly Pro Lys Val Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys 
                85                  90                  95      


Ala Leu Val Glu Ile Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser 
            100                 105                 110         


Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys 
        115                 120                 125             


Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu 
    130                 135                 140                 


Asn Lys Arg Thr Gln Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His 
145                 150                 155                 160 


Pro Ala Gly Leu Lys Lys Lys Lys Ser Val Thr Val Leu Asp Val Gly 
                165                 170                 175     


Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu Asp Phe Arg Lys Tyr Thr 
            180                 185                 190         


Ala Phe Thr Ile Pro Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr 
        195                 200                 205             


Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe 
    210                 215                 220                 


Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro 
225                 230                 235                 240 


Asp Ile Val Ile Tyr Gln Tyr Met Val Val Leu Tyr Val Gly Ser Asp 
                245                 250                 255     


Leu Glu Ile Gly Gln His Arg Thr Lys Ile Glu Glu Leu Arg Gln His 
            260                 265                 270         


Leu Leu Arg Trp Gly Leu Thr Thr Pro Asp Lys Lys His Gln Lys Glu 
        275                 280                 285             


Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr 
    290                 295                 300                 


Val Gln Pro Ile Val Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp 
305                 310                 315                 320 


Ile Gln Lys Leu Val Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Pro 
                325                 330                 335     


Gly Ile Lys Val Arg Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala 
            340                 345                 350         


Leu Thr Glu Val Ile Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala 
        355                 360                 365             


Glu Asn Arg Glu Ile Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp 
    370                 375                 380                 


Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln 
385                 390                 395                 400 


Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly 
                405                 410                 415     


Lys Tyr Ala Arg Met Arg Gly Ala His Thr Asn Asp Val Lys Gln Leu 
            420                 425                 430         


Thr Glu Ala Val Gln Lys Ile Thr Thr Glu Ser Ile Val Ile Trp Gly 
        435                 440                 445             


Lys Thr Pro Lys Phe Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Thr 
    450                 455                 460                 


Trp Trp Thr Glu Tyr Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe 
465                 470                 475                 480 


Val Asn Thr Pro Pro Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu 
                485                 490                 495     


Pro Ile Val Gly Ala Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg 
            500                 505                 510         


Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val Thr Asn Arg Gly Arg Gln 
        515                 520                 525             


Lys Val Val Thr Leu Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln 
    530                 535                 540                 


Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val 
545                 550                 555                 560 


Thr Asp Ser Gln Tyr Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Gln 
                565                 570                 575     


Ser Glu Ser Glu Leu Val Asn Gln Ile Ile Glu Gln Leu Ile Lys Lys 
            580                 585                 590         


Glu Lys Val Tyr Leu Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly 
        595                 600                 605             


Asn Glu Gln Val Asp Lys Leu Val Ser Ala Gly Ile Arg Lys Val Leu 
    610                 615                 620                 


Phe Leu Asp Gly Ile Asp Lys Ala Gln Asp Glu His Glu Lys Tyr His 
625                 630                 635                 640 


Ser Asn Trp Arg Ala Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val 
                645                 650                 655     


Ala Lys Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu 
            660                 665                 670         


Ala Met His Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Val 
        675                 680                 685             


Cys Thr His Leu Glu Gly Lys Val Ile Leu Val Ala Val His Val Ala 
    690                 695                 700                 


Ser Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu 
705                 710                 715                 720 


Thr Ala Tyr Phe Leu Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr 
                725                 730                 735     


Ile His Thr Asp Asn Gly Ser Asn Phe Thr Ser Ala Thr Val Lys Ala 
            740                 745                 750         


Ala Cys Trp Trp Ala Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn 
        755                 760                 765             


Pro Gln Ser Gln Gly Val Val Glu Ser Met Asn Lys Glu Leu Lys Lys 
    770                 775                 780                 


Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr Ala Val 
785                 790                 795                 800 


Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly 
                805                 810                 815     


Gly Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile 
            820                 825                 830         


Gln Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg 
        835                 840                 845             


Val Tyr Tyr Arg Asp Ser Arg Asn Pro Leu Trp Lys Gly Pro Ala Lys 
    850                 855                 860                 


Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp 
865                 870                 875                 880 


Ile Lys Val Val Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly 
                885                 890                 895     


Lys Gln Met Ala Gly Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp 
            900                 905                 910         


<210>  38
<211>  2739
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Encoding Variant HIV-1 POL Protein Comprising 
       D249V, D250V and D688V Substitutions

<400>  38
atgagtttgc caggaagatg gaaaccaaaa atgatagggg gaattggagg ttttatcaaa       60

gtaagacagt atgatcagat actcatagaa atctgtggac ataaagctat aggtacagta      120

ttagtaggac ctacacctgt caacataatt ggaagaaatc tgttgactca gattggttgc      180

actttaaatt ttcccattag ccctattgag actgtaccag taaaattaaa gccaggaatg      240

gatggcccaa aagttaaaca atggccattg acagaagaaa aaataaaagc attagtagaa      300

atttgtacag agatggaaaa ggaagggaaa atttcaaaaa ttgggcctga aaatccatac      360

aatactccag tatttgccat aaagaaaaaa gacagtacta aatggagaaa attagtagat      420

ttcagagaac ttaataagag aactcaagac ttctgggaag ttcaattagg aataccacat      480

cccgcagggt taaaaaagaa aaaatcagta acagtactgg atgtgggtga tgcatatttt      540

tcagttccct tagatgaaga cttcaggaaa tatactgcat ttaccatacc tagtataaac      600

aatgagacac cagggattag atatcagtac aatgtgcttc cacagggatg gaaaggatca      660

ccagcaatat tccaaagtag catgacaaaa atcttagagc cttttagaaa acaaaatcca      720

gacatagtta tctatcaata catggtcgtg ttgtatgtag gatctgactt agaaataggg      780

cagcatagaa caaaaataga ggagctgaga caacatctgt tgaggtgggg acttaccaca      840

ccagacaaaa aacatcagaa agaacctcca ttcctttgga tgggttatga actccatcct      900

gataaatgga cagtacagcc tatagtgctg ccagaaaaag acagctggac tgtcaatgac      960

atacagaagt tagtggggaa attgaattgg gcaagtcaga tttacccagg gattaaagta     1020

aggcaattat gtaaactcct tagaggaacc aaagcactaa cagaagtaat accactaaca     1080

gaagaagcag agctagaact ggcagaaaac agagagattc taaaagaacc agtacatgga     1140

gtgtattatg acccatcaaa agacttaata gcagaaatac agaagcaggg gcaaggccaa     1200

tggacatatc aaatttatca agagccattt aaaaatctga aaacaggaaa atatgcaaga     1260

atgaggggtg cccacactaa tgatgtaaaa caattaacag aggcagtgca aaaaataacc     1320

acagaaagca tagtaatatg gggaaagact cctaaattta aactgcccat acaaaaggaa     1380

acatgggaaa catggtggac agagtattgg caagccacct ggattcctga gtgggagttt     1440

gttaataccc ctcctttagt gaaattatgg taccagttag agaaagaacc catagtagga     1500

gcagaaacct tctatgtaga tggggcagct aacagggaga ctaaattagg aaaagcagga     1560

tatgttacta atagaggaag acaaaaagtt gtcaccctaa ctgacacaac aaatcagaag     1620

actgagttac aagcaattta tctagctttg caggattcgg gattagaagt aaacatagta     1680

acagactcac aatatgcatt aggaatcatt caagcacaac cagatcaaag tgaatcagag     1740

ttagtcaatc aaataataga gcagttaata aaaaaggaaa aggtctatct ggcatgggta     1800

ccagcacaca aaggaattgg aggaaatgaa caagtagata aattagtcag tgctggaatc     1860

aggaaagtac tatttttaga tggaatagat aaggcccaag atgaacatga gaaatatcac     1920

agtaattgga gagcaatggc tagtgatttt aacctgccac ctgtagtagc aaaagaaata     1980

gtagccagct gtgataaatg tcagctaaaa ggagaagcca tgcatggaca agtagactgt     2040

agtccaggaa tatggcaact agtctgtaca catttagaag gaaaagttat cctggtagca     2100

gttcatgtag ccagtggata tatagaagca gaagttattc cagcagaaac agggcaggaa     2160

acagcatatt ttcttttaaa attagcagga agatggccag taaaaacaat acatacagac     2220

aatggcagca atttcaccag tgctacggtt aaggccgcct gttggtgggc gggaatcaag     2280

caggaatttg gaattcccta caatccccaa agtcaaggag tagtagaatc tatgaataaa     2340

gaattaaaga aaattatagg acaggtaaga gatcaggctg aacatcttaa gacagcagta     2400

caaatggcag tattcatcca caattttaaa agaaaagggg ggattggggg gtacagtgca     2460

ggggaaagaa tagtagacat aatagcaaca gacatacaaa ctaaagaatt acaaaaacaa     2520

attacaaaaa ttcaaaattt tcgggtttat tacagggaca gcagaaatcc actttggaaa     2580

ggaccagcaa agctcctctg gaaaggtgaa ggggcagtag taatacaaga taatagtgac     2640

ataaaagtag tgccaagaag aaaagcaaag atcattaggg attatggaaa acagatggca     2700

ggtgatgatt gtgtggcaag tagacaggat gaggattag                            2739


<210>  39
<211>  66
<212>  DNA
<213>  SV40


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  Polynucleotide That Comprises SV40 Small t Intron

<400>  39
gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat tgtttgtgta       60

ttttag                                                                  66


<210>  40
<211>  7
<212>  PRT
<213>  SV40


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Nuclear Localization Signal of SV40 Large T Antigen

<400>  40

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  41
<211>  21
<212>  DNA
<213>  SV40


<220>
<221>  misc_feature
<222>  (1)..(21)
<223>  Polynucleotide Encoding Nuclear Localization Signal of SV40 Large
       T Antigen

<400>  41
ccaaaaaaga agagaaaggt a                                                 21


<210>  42
<211>  135
<212>  DNA
<213>  SV40


<220>
<221>  misc_feature
<222>  (1)..(135)
<223>  SV40 Poly(A) Polyadenylation Signal Site

<400>  42
aacttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca       60

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct      120

tatcatgtct ggatc                                                       135


<210>  43
<211>  196
<212>  DNA
<213>  SV40


<220>
<221>  misc_feature
<222>  (1)..(196)
<223>  SV40 Early Promoter

<400>  43
gcatctcaat tagtcagcaa ccatagtccc gcccctaact ccgcccatcc cgcccctaac       60

tccgcccagt tccgcccatt ctccgcccca tggctgacta atttttttta tttatgcaga      120

ggccgaggcc gcctcggcct ctgagctatt ccagaagtag tgaggaggct tttttggagg      180

cctaggcttt tgcaaa                                                      196


<210>  44
<211>  11282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pGAG Vector

<400>  44
ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt cctgtttttg       60

ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg      120

gttacatcga actggatctc aacagcggta agatccttga gagttttcgc cccgaagaac      180

gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta tcccgtgttg      240

acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac ttggttgagt      300

actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa ttatgcagtg      360

ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg atcggaggac      420

cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt      480

gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg atgcctgcag      540

caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta gcttcccggc      600

aacaattaat agactggatg gaggcggata aagttgcagg accacttctg cgctcggccc      660

ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg tctcgcggta      720

tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc tacacgacgg      780

ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt gcctcactga      840

ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt gatttaaaac      900

ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc atgaccaaaa      960

tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag atcaaaggat     1020

cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc     1080

taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg aaggtaactg     1140

gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag ttaggccacc     1200

acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg ttaccagtgg     1260

ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga tagttaccgg     1320

ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc ttggagcgaa     1380

cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc acgcttcccg     1440

aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga gagcgcacga     1500

gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt cgccacctct     1560

gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg aaaaacgcca     1620

gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac atgttctttc     1680

ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga gctgataccg     1740

ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc     1800

tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata tggtgcactc     1860

tcagtacaat ctgctctgat gccgcatagt taagccagta tcctcgacat cgctctagtc     1920

tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg     1980

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt     2040

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca     2100

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc     2160

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta     2220

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac     2280

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg     2340

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg     2400

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt     2460

acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca ctgcttactg     2520

gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc gagctcggat     2580

ccactagagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccggctagaa     2640

ggagagagat gggtgcgaga gcgtcagtat taagcggggg agaattagat cgatgggaaa     2700

aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata gtatgggcaa     2760

gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca gaaggctgta     2820

gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa cttagatcat     2880

tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata aaagacacca     2940

aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaaaaaa gcacagcaag     3000

cagcagctga cacaggacac agcaatcagg tcagccaaaa ttaccctata gtgcagaaca     3060

tccaggggca aatggtacat caggccatat cacctagaac tttaaatgca tgggtaaaag     3120

tagtagaaga gaaggctttc agcccagaag tgatacccat gttttcagca ttatcagaag     3180

gagccacccc acaagattta aacaccatgc taaacacagt ggggggacat caagcagcca     3240

tgcaaatgtt aaaagagacc atcaatgagg aagctgcaga atgggataga gtgcatccag     3300

tgcatgcagg gcctattgca ccaggccaga tgagagaacc aaggggaagt gacatagcag     3360

gaactactag tacccttcag gaacaaatag gatggatgac aaataatcca cctatcccag     3420

taggagaaat ttataaaaga tggataatcc tgggattaaa taaaatagta agaatgtata     3480

gccctaccag cattctggac ataagacaag gaccaaaaga accctttaga gactatgtag     3540

accggttcta taaaactcta agagccgagc aagcttcaca ggaggtaaaa aattggatga     3600

cagaaacctt gttggtccaa aatgcgaacc cagattgtaa gactatttta aaagcattgg     3660

gaccagcggc tacactagaa gaaatgatga cagcatgtca gggagtagga ggacccggcc     3720

ataaggcaag agttttggct gaagcaatga gccaagtaac aaattcagct accataatga     3780

tgcagagagg caattttagg aaccaaagaa agattgttaa gtgtttcaat tgtggcaaag     3840

aagggcacac agccagaaat tgcagggccc ctaggaaaaa gggctgttgg aaatgtggaa     3900

aggaaggaca ccaaatgaaa gattgtactg agagacaggc taatttttta gggaagatct     3960

ggccttccta caagggaagg ccagggaatt ttcttcagag cagaccagag ccaacagccc     4020

caccagaaga gagcttcagg tctggggtag agacaacaac tccccctcag aagcaggagc     4080

cgatagacaa ggaactgtat cctttaactt ccctcagatc actctttggc aacgacccct     4140

cgtcacaata aagatagggg ggcaactaaa ggaagctcta ttagatacag gagcagatga     4200

tacagtatta gaagaaatga gtttgccagg aagatggaaa ccaaaaatga tagggggaat     4260

tggaggtttt atcaaagtaa gacagtatga tcagatactc atagaaatct gtggacataa     4320

agctataggt acagtattag taggacctac acctgtcaac ataattggaa gaaatctgtt     4380

gactcagatt ggttgcactt taaattttcc cattagccct attgagactg taccagtaaa     4440

attaaagcca ggaatggatg gcccaaaagt taaacaatgg ccattgacag aagaaaaaat     4500

aaaagcatta gtagaaattt gtacagagat ggaaaaggaa gggaaaattt caaaaattgg     4560

gcctgaaaat ccatacaata ctccagtatt tgccataaag aaaaaagaca gtactaaatg     4620

gagaaaatta gtagatttca gagaacttaa taagagaact caagacttct gggaagttca     4680

attaggaata ccacatcccg cagggttaaa aaagaaaaaa tcagtaacag tactggatgt     4740

gggtgatgca tatttttcag ttcccttaga tgaagacttc aggaaatata ctgcatttac     4800

catacctagt ataaacaatg agacaccagg gattagatat cagtacaatg tgcttccaca     4860

gggatggaaa ggatcaccag caatattcca aagtagcatg acaaaaatct tagagccttt     4920

tagaaaacaa aatccagaca tagttatcta tcaatacatg gatgatttgt atgtaggatc     4980

tgacttagaa atagggcagc atagaacaaa aatagaggag ctgagacaac atctgttgag     5040

gtggggactt accacaccag acaaaaaaca tcagaaagaa cctccattcc tttggatggg     5100

ttatgaactc catcctgata aatggacagt acagcctata gtgctgccag aaaaagacag     5160

ctggactgtc aatgacatac agaagttagt ggggaaattg aattgggcaa gtcagattta     5220

cccagggatt aaagtaaggc aattatgtaa actccttaga ggaaccaaag cactaacaga     5280

agtaatacca ctaacagaag aagcagagct agaactggca gaaaacagag agattctaaa     5340

agaaccagta catggagtgt attatgaccc atcaaaagac ttaatagcag aaatacagaa     5400

gcaggggcaa ggccaatgga catatcaaat ttatcaagag ccatttaaaa atctgaaaac     5460

aggaaaatat gcaagaatga ggggtgccca cactaatgat gtaaaacaat taacagaggc     5520

agtgcaaaaa ataaccacag aaagcatagt aatatgggga aagactccta aatttaaact     5580

gcccatacaa aaggaaacat gggaaacatg gtggacagag tattggcaag ccacctggat     5640

tcctgagtgg gagtttgtta atacccctcc tttagtgaaa ttatggtacc agttagagaa     5700

agaacccata gtaggagcag aaaccttcta tgtagatggg gcagctaaca gggagactaa     5760

attaggaaaa gcaggatatg ttactaatag aggaagacaa aaagttgtca ccctaactga     5820

cacaacaaat cagaagactg agttacaagc aatttatcta gctttgcagg attcgggatt     5880

agaagtaaac atagtaacag actcacaata tgcattagga atcattcaag cacaaccaga     5940

tcaaagtgaa tcagagttag tcaatcaaat aatagagcag ttaataaaaa aggaaaaggt     6000

ctatctggca tgggtaccag cacacaaagg aattggagga aatgaacaag tagataaatt     6060

agtcagtgct ggaatcagga aagtactatt tttagatgga atagataagg cccaagatga     6120

acatgagaaa tatcacagta attggagagc aatggctagt gattttaacc tgccacctgt     6180

agtagcaaaa gaaatagtag ccagctgtga taaatgtcag ctaaaaggag aagccatgca     6240

tggacaagta gactgtagtc caggaatatg gcaactagat tgtacacatt tagaaggaaa     6300

agttatcctg gtagcagttc atgtagccag tggatatata gaagcagaag ttattccagc     6360

agaaacaggg caggaaacag catattttct tttaaaatta gcaggaagat ggccagtaaa     6420

aacaatacat acagacaatg gcagcaattt caccagtgct acggttaagg ccgcctgttg     6480

gtgggcggga atcaagcagg aatttggaat tccctacaat ccccaaagtc aaggagtagt     6540

agaatctatg aataaagaat taaagaaaat tataggacag gtaagagatc aggctgaaca     6600

tcttaagaca gcagtacaaa tggcagtatt catccacaat tttaaaagaa aaggggggat     6660

tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca tacaaactaa     6720

agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca gggacagcag     6780

aaatccactt tggaaaggac cagcaaagct cctctggaaa ggtgaagggg cagtagtaat     6840

acaagataat agtgacataa aagtagtgcc aagaagaaaa gcaaagatca ttagggatta     6900

tggaaaacag atggcaggtg atgattgtgt ggcaagtaga caggatgagg attagaacat     6960

ggaaaagttt agtaaaacac catatgtata tttcaaggaa agctaaggac tggttttata     7020

gacatcacta tgaaagtact aatccaaaaa taagttcaga agtacacatc ccactagggg     7080

atgctaaatt agtaataaca acatattggg gtctgcatac aggagaaaga gactggcatt     7140

tgggtcaggg agtctccata gaatggagga aaaagagata tagcacacaa gtagaccctg     7200

acctagcaga ccaactaatt catctgcact attttgattg tttttcagaa tctgctataa     7260

gaaataccat attaggacgt atagttagtc ctaggtgtga atatcaagca ggacataaca     7320

aggtaggatc tctacagtac ttggcactag cagcattaat aaaaccaaaa cagataaagc     7380

cacctttgcc tagtgttagg aaactgacag aggacagatg gaacaagccc cagaagacca     7440

agggccacag agggagccat acaatgaatg gacactagag cttttagagg aacttaagag     7500

tgaagctgtt agacattttc ctaggatatg gctccataac ttaggacaac atatctatga     7560

aacttacggg gatacttggg caggagtgga agccataata agaattctgc aacaactgct     7620

gtttatccat ttcagaattg ggtgtcgaca tagcagaata ggcgttactc gacagaggag     7680

agcaagaaat ggagccagta gatcctagac tagagccctg gaagcatcca ggaagtcagc     7740

ctaaaactgc ttgtaccaat tgctattgta aaaagtgttg ctttcattgc caagtttgtt     7800

tcatgacaaa agccttaggc atctcctatg gcaggaagaa gcggagacag cgacgaagag     7860

ctcatcagaa cagtcagact catcaagctt ctctatcaaa gcagtaagta gtacatgtaa     7920

tgcaacctat aatagtagca atagtagcat tagtagtagc aataataata gcaatagttg     7980

tgtggtccat agtaatcata gaatatagga aaatattaag acaaagaaaa atagacaggt     8040

taattgatag actaatagaa agagcagaag acagtggcaa tgagagtgaa ggagaagtat     8100

cagcacttgt ggagatgggg gtggaaatgg ggcaccatgc tccttgggat attgatgatc     8160

tgtagtgcta cagaaaaatt gtgggtcaca gtctattatg gggtacctgt gtggaaggaa     8220

gcaaccacca ctctattttg tgcatcagat gctaaagcat atgatacaga ggtacataat     8280

gtttgggcca cacatgcctg tgtacccaca gaccccaacc cacaagaagt agtattggta     8340

aatgtgacag aaaattttaa catgtggaaa aatgacatgg tagaacagat gcatgaggat     8400

ataatcagtt tatgggatca aagcctaaag ccatgtgtaa aattaacccc actctgtgtt     8460

agtttaaagt gcactgattt gaagaatgat actaatacca atagtagtag cgggagaatg     8520

ataatggaga aaggagagat aaaaaactgc tctttcaata tcagcacaag cataagaggt     8580

aaggtgcaga aagaatatgc atttttttat aaacttgata taataccaat agataatgat     8640

actaccagct ataagttgac aagttgtaac acctcagtca ttacacaggc ctgtccaaag     8700

gtatcctttg agccaattcc catacattat tgtgccccgg ctggttttgc gattctaaaa     8760

tgtaataata agacgttcaa tggaacagga ccatgtacaa atgtcagcac agtacaatgt     8820

acacatggaa ttaggccagt agtatcaact caactgctgt taaatggcag tctagcagaa     8880

gaagaggtag taattagatc gatcttcaga cctggaggag gagatatgag ggacaattgg     8940

agaagtgaat tatataaata taaagtagta aaaattgaac cattaggagt agcacccacc     9000

aaggcaaaga gaagagtggt gcagagagaa aaaagagcag tgggaatagg agctttgttc     9060

cttgggttct tgggagcagc aggaagcact atgggcgcag cgtcaatgac gctgacggta     9120

caggccagac aattattgtc tggtatagtg cagcagcaga acaatttgct gagggctatt     9180

gaggcgcaac agcatctgtt gcaactcaca gtctggggca tcaagcagct ccaggcaaga     9240

atcctggctg tggaaagata cctaaaggat caacagctcc tggggatttg gggttgctct     9300

ggaaaactca tttgcaccac tgctgtgcct tggaatgcta gttggagtaa taaatctctg     9360

gaacagattt ggaatcacac gacctggatg gagtgggaca gagaaattaa caattacaca     9420

agcttaatac actccttaat tgaagaatcg caaaaccagc aagaaaagaa tgaacaagaa     9480

ttattggaat tagataaatg ggcaagtttg tggaattggt ttaacataac aaattggctg     9540

tggtatataa aattattcat aatgatagta ggaggcttgg taggtttaag aatagttttt     9600

gctgtacttt ctatagtgaa tagagttagg cagggatatt caccattatc gtttcagacc     9660

cacctcccaa ccccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag     9720

agagacagag acagatccat tcgattagtg aacggatctt tgtgaaggaa ccttacttct     9780

gtggtgtgac ataattggac aaactaccta cagagattta aagctctaag gtaaatataa     9840

aatttttaag tgtataatgt gttaaactac tgattctaat tgtttgtgta ttttagattc     9900

caacctatgg aactgatgaa tgggagcagt ggtggaatgc ctttaatgag gaaaacctgt     9960

tttgctcaga agaaatgcca tctagtgatg atgaggctac tgctgactct caacattcta    10020

ctcctccaaa aaagaagaga aaggtagaag accccaagga ctttccttca gaattgctaa    10080

gttttttgag tcatgctgtg tttagtaata gaactcttgc ttgctttgct atttacacca    10140

caaaggaaaa agctgcactg ctatacaaga aaattatgga aaaatattct gtaaccttta    10200

taagtaggca taacagttat aatcataaca tactgttttt tcttactcca cacaggcata    10260

gagtgtctgc tattaataac tatgctcaaa aattgtgtac ctttagcttt ttaatttgta    10320

aaggggttaa taaggaatat ttgatgtata gtgccttgac tagagatcat aatcagccat    10380

accacatttg tagaggtttt acttgcttta aaaaacctcc cacacctccc cctgaacctg    10440

aaacataaaa tgaatgcaat tgttgttgtt aacttgttta ttgcagctta taatggttac    10500

aaataaagca atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt    10560

tgtggtttgt ccaaactcat caatgtatct tatcatgtct ggatcccgcg atgtcgaggc    10620

atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg cccctaactc    10680

cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt tatgcagagg    10740

ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt tttggaggcc    10800

taggcttttg caaaaagctt ggcgagattt tcaggagcta aggaagctaa aatggagaaa    10860

aaaatcactg gatataccac cgttgatata tcccaatggc atcgtaaaga acattttgag    10920

gcatttcagt cagttgctca atgtacctat aaccagaccg ttcagctgga tattacggcc    10980

tttttaaaga ccgtaaagaa aaataagcac aagttttatc cggcctttat tcacattctt    11040

gcccgcctga tgaatgctca tccggaattc ttgaagacga aagggcctcg tgatacgcct    11100

atttttatag gttaatgtca tgataataat ggtttcttag acgtcaggtg gcacttttcg    11160

gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa atatgtatcc    11220

gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga agagtatgag    11280

ta                                                                   11282


<210>  45
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion Protein Comprising Nuclear Localization Signal of SV40 
       Large T Antigen

<400>  45

Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys Asp Phe Pro Ser Glu 
1               5                   10                  15      


Leu Leu Ser Phe Leu Ser His Ala Val Phe Ser Asn Arg Thr Leu Ala 
            20                  25                  30          


Cys Phe Ala Ile Tyr Thr Thr Lys Glu Lys Ala Ala Leu Leu Tyr Lys 
        35                  40                  45              


Lys Ile Met Glu Lys Tyr Ser Val Thr Phe Ile Ser Arg His Asn Ser 
    50                  55                  60                  


Tyr Asn His Asn Ile Leu Phe Phe Leu Thr Pro His Arg His Arg Val 
65                  70                  75                  80  


Ser Ala Ile Asn Asn Tyr Ala Gln Lys Leu Cys Thr Phe Ser Phe Leu 
                85                  90                  95      


Ile Cys Lys Gly Val Asn Lys Glu Tyr Leu Met Tyr Ser Ala Leu Thr 
            100                 105                 110         


Arg Asp His Asn Gln Pro Tyr His Ile Cys Arg Gly Phe Thr Cys Phe 
        115                 120                 125             


Lys Lys Pro Pro Thr Pro Pro Pro Glu Pro Glu Thr 
    130                 135                 140 


<210>  46
<211>  116
<212>  PRT
<213>  Lentivirus


<220>
<221>  MISC_FEATURE
<222>  (1)..(116)
<223>  Lentiviral REV Protein

<400>  46

Met Ala Gly Arg Ser Gly Asp Ser Asp Glu Glu Leu Ile Arg Thr Val 
1               5                   10                  15      


Arg Leu Ile Lys Leu Leu Tyr Gln Ser Asn Pro Pro Pro Asn Pro Glu 
            20                  25                  30          


Gly Thr Arg Gln Ala Arg Arg Asn Arg Arg Arg Arg Trp Arg Glu Arg 
        35                  40                  45              


Gln Arg Gln Ile His Ser Ile Ser Glu Arg Ile Leu Gly Thr Tyr Leu 
    50                  55                  60                  


Gly Arg Ser Ala Glu Pro Val Pro Leu Gln Leu Pro Pro Leu Glu Arg 
65                  70                  75                  80  


Leu Thr Leu Asp Cys Asn Glu Asp Cys Gly Thr Ser Gly Thr Gln Gly 
                85                  90                  95      


Val Gly Ser Pro Gln Ile Leu Val Glu Ser Pro Thr Val Leu Glu Ser 
            100                 105                 110         


Gly Thr Lys Glu 
        115     


<210>  47
<211>  1582
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(1582)
<223>  Polynucleotide Capable of Being Processed to Form Lentiviral Rev 
       Protein

<400>  47
atgctgctac cattgtcaga tgtgttttct aaacaagggg ctcggaattc cccggatccg       60

tcgactctag aggatctgca tctcctatgg caggaagaag cggagacagc gacgaagacc      120

tcctcaaggc agtcagactc atcaagtttc tctatcaaag caacccacct cccaatcccg      180

aggggacccg acaggcccga aggaatagaa gaagaaggtg gagagagaga cagagacaga      240

tccattcgat tagtgaacgg atccttagca cttatctggg acgatctgcg gagcctgtgc      300

ctcttcagct accaccgctt gagagactta ctcttgattg taacgaggat tgtggaactt      360

ctgggacgca gggggtggga agccctcaaa tattggtgga atctcctaca atattggagt      420

caggagctaa agaatagtgc tgttagcttg ctcaatgcca cagctatagc agtagctgag      480

gggacagata gggttataga agtagtacaa gaagcttata gagctattcg ccacatacct      540

agaagaataa gacagggctt ggaaaggatt ttgctataag atgggtggca agtggtcaaa      600

aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg agacgagctg agccagcagc      660

agatggggtg ggagcagcat ctcgagacct agaaaaacat ggagcaatca caagtagcaa      720

cacagcagct aacaatgctg cttgtgcctg gctagaagca caagaggagg agaaggtggg      780

ttttccagtc acacctcagg taccgagctc gaattcactc ctcaggtgca ggctgcctat      840

cagaaggtgg tggctggtgt ggccaatgcc ctggctcaca aataccactg agatctttgt      900

gaaggaacct tacttctgtg gtgtgacata attggacaaa ctacctacag agatttaaag      960

ctctaaggta aatataaaat ttttaagtgt ataatgtgtt aaactactga ttctaattgt     1020

ttgtgtattt tagattccaa cctatggaac tgatgaatgg gagcagtggt ggaatgcctt     1080

taatgaggaa aacctgtttt gctcagaaga aatgccatct agtgatgatg aggctactgc     1140

tgactctcaa cattctactc ctccaaaaaa gaagagaaag gtagaagacc ccaaggactt     1200

tccttcagaa ttgctaagtt ttttgagtca tgctgtgttt agtaatagaa ctcttgcttg     1260

ctttgctatt tacaccacaa aggaaaaagc tgcactgcta tacaagaaaa ttatggaaaa     1320

atattctgta acctttataa gtaggcataa cagttataat cataacatac tgttttttct     1380

tactccacac aggcatagag tgtctgctat taataactat gctcaaaaat tgtgtacctt     1440

tagcttttta atttgtaaag gggttaataa ggaatatttg atgtatagtg ccttgactag     1500

agatcataat cagccatacc acatttgtag aggttttact tgctttaaaa aacctcccac     1560

acctccccct gaacctgaaa ca                                              1582


<210>  48
<211>  66
<212>  DNA
<213>  SV40


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  SV40 Small t Antigen Intron

<400>  48
gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat tgtttgtgta       60

ttttag                                                                  66


<210>  49
<211>  5514
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pREV Vector

<400>  49
gagaggacat tccaatcata ggctgcccat ccaccctctg tgtcctcctg ttaattaggt       60

cacttaacaa aaaggaaatt gggtaggggt ttttcacaga ccgctttcta agggtaattt      120

taaaatatct gggaagtccc ttccactgct gtgttccaga agtgttggta aacagcccac      180

aaatgtcaac agcagaaaca tacaagctgt cagctttgca caagggccca acaccctgct      240

catcaagaag cactgtggtt gctgtgttag taatgtgcaa aacaggaggc acattttccc      300

cacctgtgta ggttccaaaa tatctagtgt tttcattttt acttggatca ggaacccagc      360

actccactgg ataagcatta tccttatcca aaacagcctt gtggtcagtg ttcatctgct      420

gactgtcaac tgtagcattt tttggggtta cagtttgagc aggatatttg gtcctgtagt      480

ttgctaacac accctgcagc tccaaaggtt ccccaccaac agcaaaaaaa tgaaaatttg      540

acccttgaat gggttttcca gcaccatttt catgagtttt ttgtgtccct gaatgcaagt      600

ttaacatagc agttacccca ataacctcag ttttaacagt aacagcttcc cacatcaaaa      660

tatttccaca ggttaagtcc tcatttaaat taggcaaagg aattcttgaa gacgaaaggg      720

cctcgtgata cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc      780

aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca      840

ttcaaatatg tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa      900

aaggaagagt atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt      960

ttgccttcct gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca     1020

gttgggtgca cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag     1080

ttttcgcccc gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc     1140

ggtattatcc cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca     1200

gaatgacttg gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt     1260

aagagaatta tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct     1320

gacaacgatc ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt     1380

aactcgcctt gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga     1440

caccacgatg cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact     1500

tactctagct tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc     1560

acttctgcgc tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga     1620

gcgtgggtct cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt     1680

agttatctac acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga     1740

gataggtgcc tcactgatta agcattggta actgtcagac caagtttact catatatact     1800

ttagattgat ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga     1860

taatctcatg accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt     1920

agaaaagatc aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca     1980

aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct     2040

ttttccgaag gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta     2100

gccgtagtta ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct     2160

aatcctgtta ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc     2220

aagacgatag ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca     2280

gcccagcttg gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga     2340

aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg     2400

aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt     2460

cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag     2520

cctatggaaa aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt     2580

tgctcacatg ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt     2640

tgagtgagct gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga     2700

ggaagcggaa gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca     2760

ccgcatatgg tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatcc     2820

tcgaggcctc caaaaaagcc tcctcactac ttctggaata gctcagaggc cgaggcggcc     2880

tcggcctctg cataaataaa aaaaattagt cagccatgag cttggcccat tgcatacgtt     2940

gtatccatat cataatatgt acatttatat tggctcatgt ccaacattac cgccatgttg     3000

acattgatta ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc     3060

atatatggag ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa     3120

cgacccccgc ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac     3180

tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca     3240

agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg     3300

gcattatgcc cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt     3360

agtcatcgct attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg     3420

gtttgactca cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg     3480

gcaccaaaat caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat     3540

gggcggtagg cgtgtacggt gggaggtcta tataagcaga gctcattaaa gtcctgcaac     3600

gagccctttt cacgcacttc agagcaggat gtggccactc aagaattggc cagacaaggg     3660

gaggaaatcc tctctcagct ataccgaccc ctagaaacat gcaataactc atgctattgt     3720

aagcgatgct gctaccattg tcagatgtgt tttctaaaca aggggctcgg aattccccgg     3780

atccgtcgac tctagaggat ctgcatctcc tatggcagga agaagcggag acagcgacga     3840

agacctcctc aaggcagtca gactcatcaa gtttctctat caaagcaacc cacctcccaa     3900

tcccgagggg acccgacagg cccgaaggaa tagaagaaga aggtggagag agagacagag     3960

acagatccat tcgattagtg aacggatcct tagcacttat ctgggacgat ctgcggagcc     4020

tgtgcctctt cagctaccac cgcttgagag acttactctt gattgtaacg aggattgtgg     4080

aacttctggg acgcaggggg tgggaagccc tcaaatattg gtggaatctc ctacaatatt     4140

ggagtcagga gctaaagaat agtgctgtta gcttgctcaa tgccacagct atagcagtag     4200

ctgaggggac agatagggtt atagaagtag tacaagaagc ttatagagct attcgccaca     4260

tacctagaag aataagacag ggcttggaaa ggattttgct ataagatggg tggcaagtgg     4320

tcaaaaagta gtgtggttgg atggcctgct gtaagggaaa gaatgagacg agctgagcca     4380

gcagcagatg gggtgggagc agcatctcga gacctagaaa aacatggagc aatcacaagt     4440

agcaacacag cagctaacaa tgctgcttgt gcctggctag aagcacaaga ggaggagaag     4500

gtgggttttc cagtcacacc tcaggtaccg agctcgaatt cactcctcag gtgcaggctg     4560

cctatcagaa ggtggtggct ggtgtggcca atgccctggc tcacaaatac cactgagatc     4620

tttgtgaagg aaccttactt ctgtggtgtg acataattgg acaaactacc tacagagatt     4680

taaagctcta aggtaaatat aaaattttta agtgtataat gtgttaaact actgattcta     4740

attgtttgtg tattttagat tccaacctat ggaactgatg aatgggagca gtggtggaat     4800

gcctttaatg aggaaaacct gttttgctca gaagaaatgc catctagtga tgatgaggct     4860

actgctgact ctcaacattc tactcctcca aaaaagaaga gaaaggtaga agaccccaag     4920

gactttcctt cagaattgct aagttttttg agtcatgctg tgtttagtaa tagaactctt     4980

gcttgctttg ctatttacac cacaaaggaa aaagctgcac tgctatacaa gaaaattatg     5040

gaaaaatatt ctgtaacctt tataagtagg cataacagtt ataatcataa catactgttt     5100

tttcttactc cacacaggca tagagtgtct gctattaata actatgctca aaaattgtgt     5160

acctttagct ttttaatttg taaaggggtt aataaggaat atttgatgta tagtgccttg     5220

actagagatc ataatcagcc ataccacatt tgtagaggtt ttacttgctt taaaaaacct     5280

cccacacctc cccctgaacc tgaaacataa aatgaatgca attgttgttg ttaacttgtt     5340

tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca caaataaagc     5400

atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat cttatcatgt     5460

ctggatcccc aggaagctcc tctgtgtcct cataaaccct aacctcctct actt           5514


<210>  50
<211>  17
<212>  DNA
<213>  Bacteriophage M13


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  Forward Primer Binding Site

<400>  50
gtaaaacgac ggccagt                                                      17


<210>  51
<211>  17
<212>  DNA
<213>  Bacteriophage M13


<220>
<221>  misc_feature
<223>  Reverse Primer Binding Site

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  Reverse Primer Binding Site

<400>  51
caggaaacag ctatgac                                                      17


<210>  52
<211>  204
<212>  DNA
<213>  Human Cytomegalovirus (CMV)


<220>
<221>  misc_feature
<222>  (1)..(204)
<223>  Human Cytomegalovirus (CMV) Immediate Early Promoter Site

<400>  52
gtgatgcggt tttggcagta catcaatggg cgtggatagc ggtttgactc acggggattt       60

ccaagtctcc accccattga cgtcaatggg agtttgtttt ggcaccaaaa tcaacgggac      120

tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa tgggcggtag gcgtgtacgg      180

tgggaggtct atataagcag agct                                             204


<210>  53
<211>  573
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(573)
<223>  Beta-Globin Intron

<400>  53
gtgagtttgg ggacccttga ttgttctttc tttttcgcta ttgtaaaatt catgttatat       60

ggagggggca aagttttcag ggtgttgttt agaatgggaa gatgtccctt gtatcaccat      120

ggaccctcat gataattttg tttctttcac tttctactct gttgacaacc attgtctcct      180

cttattttct tttcattttc tgtaactttt tcgttaaact ttagcttgca tttgtaacga      240

atttttaaat tcacttttgt ttatttgtca gattgtaagt actttctcta atcacttttt      300

tttcaaggca atcagggtat attatattgt acttcagcac agttttagag aacaattgtt      360

ataattaaat gataaggtag aatatttctg catataaatt ctggctggcg tggaaatatt      420

cttattggta gaaacaacta caccctggtc atcatcctgc ctttctcttt atggttacaa      480

tgatatacac tgtttgagat gaggataaaa tactctgagt ccaaaccggg cccctctgct      540

aaccatgttc atgccttctt ctctttccta cag                                   573


<210>  54
<211>  1255
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(1255)
<223>  SARS-CoV-2 S Protein Lacking C-Terminal 18 Amino Acid Residues

<400>  54

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  
    1250                 1255 


<210>  55
<211>  3765
<212>  DNA
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(3765)
<223>  Polynucleotide Encoding SARS-CoV-2 S Protein Lacking C-Terminal 
       18 Amino Acid Residues

<400>  55
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc       60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac      120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc      180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat      240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata      300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt      360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt      420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat      480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa      540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat      600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt      660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact      720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct      780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat      840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag      900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc      960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa     1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac     1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat     1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt     1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat     1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat     1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat     1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt     1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact     1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca     1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat     1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg     1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag     1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca     1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc     1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct     1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat     1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct     2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt     2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt     2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg     2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt     2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa     2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt     2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat     2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc     2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt     2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt     2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg     2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa     2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc     2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac     2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc     2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga     3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct     3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt     3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta     3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc     3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca     3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca     3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct     3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca     3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa     3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc     3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt     3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc     3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaa                     3765


<210>  56
<211>  56
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(56)
<223>  Beta-Globin Poly(A) Polyadenylation Signal Sequence

<400>  56
aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctca           56


<210>  57
<211>  17
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  Lac Operator Site

<400>  57
ttgtgagcgg ataacaa                                                      17


<210>  58
<211>  31
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(31)
<223>  Lac Promoter Site

<400>  58
tttacacttt atgcttccgg ctcgtatgtt g                                      31


<210>  59
<211>  22
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<222>  (1)..(22)
<223>  Catabolite Activator Protein (CAP) Binding Site

<400>  59
taatgtgagt tagctcactc at                                                22


<210>  60
<211>  456
<212>  DNA
<213>  Bacteriophage f1


<220>
<221>  misc_feature
<222>  (1)..(456)
<223>  Origin of Replication

<400>  60
acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg       60

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca      120

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta      180

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc      240

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg      300

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat      360

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta      420

acgcgaattt taacaaaata ttaacgctta caattt                                456


<210>  61
<211>  8602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pCMV-SARS-CoV-2 S Protein Vector

<400>  61
gttttcccag tcacgacgtt gtaaaacgac ggccagtgag cgcgcgtaat acgactcact       60

atagggcgaa ttggagctcc accgcggtgg cggccgctct agagagcttg gcccattgca      120

tacgttgtat ccatatcata atatgtacat ttatattggc tcatgtccaa cattaccgcc      180

atgttgacat tgattattga ctagttatta atagtaatca attacggggt cattagttca      240

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc      300

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat      360

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt      420

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc      480

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta      540

cgtattagtc atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg      600

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt      660

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac      720

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa      780

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga      840

ccgatccagc ctccggtcga ccgatcctga gaacttcagg gtgagtttgg ggacccttga      900

ttgttctttc tttttcgcta ttgtaaaatt catgttatat ggagggggca aagttttcag      960

ggtgttgttt agaatgggaa gatgtccctt gtatcaccat ggaccctcat gataattttg     1020

tttctttcac tttctactct gttgacaacc attgtctcct cttattttct tttcattttc     1080

tgtaactttt tcgttaaact ttagcttgca tttgtaacga atttttaaat tcacttttgt     1140

ttatttgtca gattgtaagt actttctcta atcacttttt tttcaaggca atcagggtat     1200

attatattgt acttcagcac agttttagag aacaattgtt ataattaaat gataaggtag     1260

aatatttctg catataaatt ctggctggcg tggaaatatt cttattggta gaaacaacta     1320

caccctggtc atcatcctgc ctttctcttt atggttacaa tgatatacac tgtttgagat     1380

gaggataaaa tactctgagt ccaaaccggg cccctctgct aaccatgttc atgccttctt     1440

ctctttccta cagctcctgg gcaacgtgct ggttgttgtg ctgtctcatc attttggcaa     1500

agaattcctc gacggatccg gtaccgagga gatctgccgc cgcgatcgcc accatgtttg     1560

tttttcttgt tttattgcca ctagtctcta gtcagtgtgt taatcttaca accagaactc     1620

aattaccccc tgcatacact aattctttca cacgtggtgt ttattaccct gacaaagttt     1680

tcagatcctc agttttacat tcaactcagg acttgttctt acctttcttt tccaatgtta     1740

cttggttcca tgctatacat gtctctggga ccaatggtac taagaggttt gataaccctg     1800

tcctaccatt taatgatggt gtttattttg cttccactga gaagtctaac ataataagag     1860

gctggatttt tggtactact ttagattcga agacccagtc cctacttatt gttaataacg     1920

ctactaatgt tgttattaaa gtctgtgaat ttcaattttg taatgatcca tttttgggtg     1980

tttattacca caaaaacaac aaaagttgga tggaaagtga gttcagagtt tattctagtg     2040

cgaataattg cacttttgaa tatgtctctc agccttttct tatggacctt gaaggaaaac     2100

agggtaattt caaaaatctt agggaatttg tgtttaagaa tattgatggt tattttaaaa     2160

tatattctaa gcacacgcct attaatttag tgcgtgatct ccctcagggt ttttcggctt     2220

tagaaccatt ggtagatttg ccaataggta ttaacatcac taggtttcaa actttacttg     2280

ctttacatag aagttatttg actcctggtg attcttcttc aggttggaca gctggtgctg     2340

cagcttatta tgtgggttat cttcaaccta ggacttttct attaaaatat aatgaaaatg     2400

gaaccattac agatgctgta gactgtgcac ttgaccctct ctcagaaaca aagtgtacgt     2460

tgaaatcctt cactgtagaa aaaggaatct atcaaacttc taactttaga gtccaaccaa     2520

cagaatctat tgttagattt cctaatatta caaacttgtg cccttttggt gaagttttta     2580

acgccaccag atttgcatct gtttatgctt ggaacaggaa gagaatcagc aactgtgttg     2640

ctgattattc tgtcctatat aattccgcat cattttccac ttttaagtgt tatggagtgt     2700

ctcctactaa attaaatgat ctctgcttta ctaatgtcta tgcagattca tttgtaatta     2760

gaggtgatga agtcagacaa atcgctccag ggcaaactgg aaagattgct gattataatt     2820

ataaattacc agatgatttt acaggctgcg ttatagcttg gaattctaac aatcttgatt     2880

ctaaggttgg tggtaattat aattacctgt atagattgtt taggaagtct aatctcaaac     2940

cttttgagag agatatttca actgaaatct atcaggccgg tagcacacct tgtaatggtg     3000

ttgaaggttt taattgttac tttcctttac aatcatatgg tttccaaccc actaatggtg     3060

ttggttacca accatacaga gtagtagtac tttcttttga acttctacat gcaccagcaa     3120

ctgtttgtgg acctaaaaag tctactaatt tggttaaaaa caaatgtgtc aatttcaact     3180

tcaatggttt aacaggcaca ggtgttctta ctgagtctaa caaaaagttt ctgcctttcc     3240

aacaatttgg cagagacatt gctgacacta ctgatgctgt ccgtgatcca cagacacttg     3300

agattcttga cattacacca tgttcttttg gtggtgtcag tgttataaca ccaggaacaa     3360

atacttctaa ccaggttgct gttctttatc aggatgttaa ctgcacagaa gtccctgttg     3420

ctattcatgc agatcaactt actcctactt ggcgtgttta ttctacaggt tctaatgttt     3480

ttcaaacacg tgcaggctgt ttaatagggg ctgaacatgt caacaactca tatgagtgtg     3540

acatacccat tggtgcaggt atatgcgcta gttatcagac tcagactaat tctcctcggc     3600

gggcacgtag tgtagctagt caatccatca ttgcctacac tatgtcactt ggtgcagaaa     3660

attcagttgc ttactctaat aactctattg ccatacccac aaattttact attagtgtta     3720

ccacagaaat tctaccagtg tctatgacca agacatcagt agattgtaca atgtacattt     3780

gtggtgattc aactgaatgc agcaatcttt tgttgcaata tggcagtttt tgtacacaat     3840

taaaccgtgc tttaactgga atagctgttg aacaagacaa aaacacccaa gaagtttttg     3900

cacaagtcaa acaaatttac aaaacaccac caattaaaga ttttggtggt tttaattttt     3960

cacaaatatt accagatcca tcaaaaccaa gcaagaggtc atttattgaa gatctacttt     4020

tcaacaaagt gacacttgca gatgctggct tcatcaaaca atatggtgat tgccttggtg     4080

atattgctgc tagagacctc atttgtgcac aaaagtttaa cggccttact gttttgccac     4140

ctttgctcac agatgaaatg attgctcaat acacttctgc actgttagcg ggtacaatca     4200

cttctggttg gacctttggt gcaggtgctg cattacaaat accatttgct atgcaaatgg     4260

cttataggtt taatggtatt ggagttacac agaatgttct ctatgagaac caaaaattga     4320

ttgccaacca atttaatagt gctattggca aaattcaaga ctcactttct tccacagcaa     4380

gtgcacttgg aaaacttcaa gatgtggtca accaaaatgc acaagcttta aacacgcttg     4440

ttaaacaact tagctccaat tttggtgcaa tttcaagtgt tttaaatgat atcctttcac     4500

gtcttgacaa agttgaggct gaagtgcaaa ttgataggtt gatcacaggc agacttcaaa     4560

gtttgcagac atatgtgact caacaattaa ttagagctgc agaaatcaga gcttctgcta     4620

atcttgctgc tactaaaatg tcagagtgtg tacttggaca atcaaaaaga gttgattttt     4680

gtggaaaggg ctatcatctt atgtccttcc ctcagtcagc acctcatggt gtagtcttct     4740

tgcatgtgac ttatgtccct gcacaagaaa agaacttcac aactgctcct gccatttgtc     4800

atgatggaaa agcacacttt cctcgtgaag gtgtctttgt ttcaaatggc acacactggt     4860

ttgtaacaca aaggaatttt tatgaaccac aaatcattac tacagacaac acatttgtgt     4920

ctggtaactg tgatgttgta ataggaattg tcaacaacac agtttatgat cctttgcaac     4980

ctgaattaga ctcattcaag gaggagttag ataaatattt taagaatcat acatcaccag     5040

atgttgattt aggtgacatc tctggcatta atgcttcagt tgtaaacatt caaaaagaaa     5100

ttgaccgcct caatgaggtt gccaagaatt taaatgaatc tctcatcgat ctccaagaac     5160

ttggaaagta tgagcagtat ataaaatggc catggtacat ttggctaggt tttatagctg     5220

gcttgattgc catagtaatg gtgacaatta tgctttgctg tatgaccagt tgctgtagtt     5280

gtctcaaggg ctgttgttct tgtggatcct gctgcaaata acctcaggtg caggctgcct     5340

atcagaaggt ggtggctggt gtggccaatg ccctggctca caaataccac tgagatcttt     5400

ttccctctgc caaaaattat ggggacatca tgaagcccct tgagcatctg acttctggct     5460

aataaaggaa atttattttc attgcaatag tgtgttggaa ttttttgtgt ctctcactcg     5520

gaaggacata tgggagggca aatcatttaa aacatcagaa tgagtatttg gtttagagtt     5580

tggcaacata tgcccatatg ctggctgcca tgaacaaagg ttggctataa agaggtcatc     5640

agtatatgaa acagccccct gctgtccatt ccttattcca tagaaaagcc ttgacttgag     5700

gttagatttt ttttatattt tgttttgtgt tatttttttc tttaacatcc ctaaaatttt     5760

ccttacatgt tttactagcc agatttttcc tcctctcctg actactccca gtcatagctg     5820

tccctcttct cttatggaga tccctcgacg gatcggccgc aattcgtaat catgtcatag     5880

ctgtttcctg tgtgaaattg ttatccgctc acaattccac acaacatacg agccggaagc     5940

ataaagtgta aagcctgggg tgcctaatga gtgagctaac tcacattaat tgcgttgcgc     6000

tcactgcccg ctttccagtc gggaaacctg tcgtgccagc tgcattaatg aatcggccaa     6060

cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct cactgactcg     6120

ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc ggtaatacgg     6180

ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg ccagcaaaag     6240

gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg cccccctgac     6300

gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg actataaaga     6360

taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac cctgccgctt     6420

accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca tagctcacgc     6480

tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt gcacgaaccc     6540

cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc caacccggta     6600

agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag agcgaggtat     6660

gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac tagaagaaca     6720

gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt tggtagctct     6780

tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa gcagcagatt     6840

acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg gtctgacgct     6900

cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa aaggatcttc     6960

acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat atatgagtaa     7020

acttggtctg acagttacca atgcttaatc agtgaggcac ctatctcagc gatctgtcta     7080

tttcgttcat ccatagttgc ctgactcccc gtcgtgtaga taactacgat acgggagggc     7140

ttaccatctg gccccagtgc tgcaatgata ccgcgagacc cacgctcacc ggctccagat     7200

ttatcagcaa taaaccagcc agccggaagg gccgagcgca gaagtggtcc tgcaacttta     7260

tccgcctcca tccagtctat taattgttgc cgggaagcta gagtaagtag ttcgccagtt     7320

aatagtttgc gcaacgttgt tgccattgct acaggcatcg tggtgtcacg ctcgtcgttt     7380

ggtatggctt cattcagctc cggttcccaa cgatcaaggc gagttacatg atcccccatg     7440

ttgtgcaaaa aagcggttag ctccttcggt cctccgatcg ttgtcagaag taagttggcc     7500

gcagtgttat cactcatggt tatggcagca ctgcataatt ctcttactgt catgccatcc     7560

gtaagatgct tttctgtgac tggtgagtac tcaaccaagt cattctgaga atagtgtatg     7620

cggcgaccga gttgctcttg cccggcgtca atacgggata ataccgcgcc acatagcaga     7680

actttaaaag tgctcatcat tggaaaacgt tcttcggggc gaaaactctc aaggatctta     7740

ccgctgttga gatccagttc gatgtaaccc actcgtgcac ccaactgatc ttcagcatct     7800

tttactttca ccagcgtttc tgggtgagca aaaacaggaa ggcaaaatgc cgcaaaaaag     7860

ggaataaggg cgacacggaa atgttgaata ctcatactct tcctttttca atattattga     7920

agcatttatc agggttattg tctcatgagc ggatacatat ttgaatgtat ttagaaaaat     7980

aaacaaatag gggttccgcg cacatttccc cgaaaagtgc cacctaaatt gtaagcgtta     8040

atattttgtt aaaattcgcg ttaaattttt gttaaatcag ctcatttttt aaccaatagg     8100

ccgaaatcgg caaaatccct tataaatcaa aagaatagac cgagataggg ttgagtgttg     8160

ttccagtttg gaacaagagt ccactattaa agaacgtgga ctccaacgtc aaagggcgaa     8220

aaaccgtcta tcagggcgat ggcccactac gtgaaccatc accctaatca agttttttgg     8280

ggtcgaggtg ccgtaaagca ctaaatcgga accctaaagg gagcccccga tttagagctt     8340

gacggggaaa gccggcgaac gtggcgagaa aggaagggaa gaaagcgaaa ggagcgggcg     8400

ctagggcgct ggcaagtgta gcggtcacgc tgcgcgtaac caccacaccc gccgcgctta     8460

atgcgccgct acagggcgcg tcccattcgc cattcaggct gcgcaactgt tgggaagggc     8520

gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt gctgcaaggc     8580

gattaagttg ggtaacgcca gg                                              8602


<210>  62
<211>  453
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(453)
<223>  Native Lentiviral LTR U3 Region

<400>  62
tggaagggct aattcactcc caacgaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tggcagaact acacaccagg gccagggatc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagca agagaaggta gaagaagcca      180

atgaaggaga gaacacccgc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt attagagtgg aggtttgaca gccgcctagc atttcatcac atggcccgag      300

agctgcatcc ggagtacttc aagaactgct gacatcgagc ttgctacaag ggactttccg      360

ctggggactt tccagggagg cgtggcctgg gcgggactgg ggagtggcga gccctcagat      420

cctgcatata agcagctgct ttttgcctgt act                                   453


<210>  63
<211>  320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lentiviral LTR U3 Region Comprising Internal Deletion of 133 
       Residues

<400>  63
tggaagggct aattcactcc caacgaagac aagatatcct tgatctgtgg atctaccaca       60

cacaaggcta cttccctgat tggcagaact acacaccagg gccagggatc agatatccac      120

tgacctttgg atggtgctac aagctagtac cagttgagca agagaaggta gaagaagcca      180

atgaaggaga gaacacccgc ttgttacacc ctgtgagcct gcatgggatg gatgacccgg      240

agagagaagt attagagtgg aggtttgaca gccgcctagc atttcatcac atggcccgag      300

agctgcatcc ggactgtact                                                  320


<210>  64
<211>  318
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant Lentiviral LTR U3 Region Comprising Internal Deletion of 
       133 Residues

<400>  64
gaagggctaa ttcactccca acgaagacaa gatctgcttg atctgtggat ctaccacaca       60

caaggctact tccctgattg gcagaactac acaccagggc cagggatcag atatccactg      120

acctttggat ggtgctacaa gctagtacca gttgagcaag agaaggtaga agaagccaat      180

gaaggagaga acacccgctt gttacaccct gtgagcctgc atgggatgga tgacccggag      240

agagaagtat tagagtggag gtttgacagc cgcctagcat ttcatcacat ggcccgagag      300

ctgcatccgg actgtact                                                    318


<210>  65
<211>  288
<212>  PRT
<213>  Lentivirus


<220>
<221>  MISC_FEATURE
<222>  (1)..(288)
<223>  Wildtype Lentiviral Integrase Protein

<400>  65

Phe Leu Asp Gly Ile Asp Lys Ala Gln Asp Glu His Glu Lys Tyr His 
1               5                   10                  15      


Ser Asn Trp Arg Ala Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val 
            20                  25                  30          


Ala Lys Glu Ile Val Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu 
        35                  40                  45              


Ala Met His Gly Gln Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp 
    50                  55                  60                  


Cys Thr His Leu Glu Gly Lys Val Ile Leu Val Ala Val His Val Ala 
65                  70                  75                  80  


Ser Gly Tyr Ile Glu Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu 
                85                  90                  95      


Thr Ala Tyr Phe Leu Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr 
            100                 105                 110         


Ile His Thr Asp Asn Gly Ser Asn Phe Thr Ser Ala Thr Val Lys Ala 
        115                 120                 125             


Ala Cys Trp Trp Ala Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn 
    130                 135                 140                 


Pro Gln Ser Gln Gly Val Val Glu Ser Met Asn Lys Glu Leu Lys Lys 
145                 150                 155                 160 


Ile Ile Gly Gln Val Arg Asp Gln Ala Glu His Leu Lys Thr Ala Val 
                165                 170                 175     


Gln Met Ala Val Phe Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly 
            180                 185                 190         


Gly Tyr Ser Ala Gly Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile 
        195                 200                 205             


Gln Thr Lys Glu Leu Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg 
    210                 215                 220                 


Val Tyr Tyr Arg Asp Ser Arg Asn Pro Leu Trp Lys Gly Pro Ala Lys 
225                 230                 235                 240 


Leu Leu Trp Lys Gly Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp 
                245                 250                 255     


Ile Lys Val Val Pro Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly 
            260                 265                 270         


Lys Gln Met Ala Gly Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp 
        275                 280                 285             


<210>  66
<211>  864
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(864)
<223>  Polynucleotide Encoding Wildtype Lentiviral Integrase Protein

<400>  66
tttttagatg gaatagataa ggcccaagat gaacatgaga aatatcacag taattggaga       60

gcaatggcta gtgattttaa cctgccacct gtagtagcaa aagaaatagt agccagctgt      120

gataaatgtc agctaaaagg agaagccatg catggacaag tagactgtag tccaggaata      180

tggcaactag attgtacaca tttagaagga aaagttatcc tggtagcagt tcatgtagcc      240

agtggatata tagaagcaga agttattcca gcagaaacag ggcaggaaac agcatatttt      300

cttttaaaat tagcaggaag atggccagta aaaacaatac atacagacaa tggcagcaat      360

ttcaccagtg ctacggttaa ggccgcctgt tggtgggcgg gaatcaagca ggaatttgga      420

attccctaca atccccaaag tcaaggagta gtagaatcta tgaataaaga attaaagaaa      480

attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca aatggcagta      540

ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg ggaaagaata      600

gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat tacaaaaatt      660

caaaattttc gggtttatta cagggacagc agaaatccac tttggaaagg accagcaaag      720

ctcctctgga aaggtgaagg ggcagtagta atacaagata atagtgacat aaaagtagtg      780

ccaagaagaa aagcaaagat cattagggat tatggaaaac agatggcagg tgatgattgt      840

gtggcaagta gacaggatga ggat                                             864


<210>  67
<211>  7267
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLenti-CMV-IRES-empty (-att) Vector

<400>  67
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat cgcgttgaca      240

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagcgcg ttttgcctgt actgggtctc      840

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      900

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      960

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct aggtggcgcc     1020

cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc     1080

ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt     1140

tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga     1200

gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat     1260

taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt     1320

tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag     1380

gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa     1440

ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa     1500

gtaagaccac cgcacagcaa gcggccggcc gctgatcttc agacctggag gaggagatat     1560

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1620

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1680

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat     1740

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1800

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1860

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1920

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1980

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     2040

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     2100

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     2160

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     2220

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     2280

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     2340

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat cggcactgcg     2400

tgcgccaatt ctgcagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga     2460

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta     2520

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca     2580

gagatccagt ttggttagta ccgggcccgc tctagacatg tccaatatga ccgccatgtt     2640

gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc     2700

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     2760

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     2820

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     2880

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     2940

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat     3000

tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc     3060

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     3120

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa     3180

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     3240

agaattttgt aatacgactc actatagggc ggccgggaat tcgtcgactg cccccccccc     3300

taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt     3360

ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt     3420

gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt     3480

cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct     3540

ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt     3600

ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt     3660

ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa     3720

ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta     3780

gtcgaggtta aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa     3840

acacgatgat aatgatccgg taccgaggag atctgccgcc gcgatcgccg gcgcgccaga     3900

tctcaagctt aactagctag cggaccgacg cgtacgcggc cgctcgagca gaaactcatc     3960

tcagaagagg atctggcagc aaatgatatc ctggattaca aggatgacga cgataaggtt     4020

taaacggccg gccgcggtct gtacaagtag gattcgtcga gggacctaat aacttcgtat     4080

agcatacatt atacgaagtt atacatgttt aagggttccg gttccactag gtacaattcg     4140

atatcaagct tatcgataat caacctctgg attacaaaat ttgtgaaaga ttgactggta     4200

ttcttaacta tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc     4260

atgctattgc ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt     4320

ctctttatga ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg     4380

ctgacgcaac ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt     4440

tcgctttccc cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct     4500

ggacaggggc tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt     4560

cctttccttg gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct     4620

acgtcccttc ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc     4680

ggcctcttcc gcgtcttcgc cttcgccctc agacgagtcg gatctccctt tgggccgcct     4740

ccccgcatcg ataccgtcga cctcgatcga gacctagaaa aacatggagc aatcacaagt     4800

agcaatacag cagctaccaa tgctgattgt gcctggctag aagcacaaga ggaggaggag     4860

gtgggttttc cagtcacacc tcaggtacct ttaagaccaa tgacttacaa ggcagctgta     4920

gatcttagcc actttttaaa agaaaagggg ggacgaaggg ctaattcact cccaacgaag     4980

acaagatctg cttgatctgt ggatctacca cacacaaggc tacttccctg attggcagaa     5040

ctacacacca gggccaggga tcagatatcc actgaccttt ggatggtgct acaagctagt     5100

accagttgag caagagaagg tagaagaagc caatgaagga gagaacaccc gcttgttaca     5160

ccctgtgagc ctgcatggga tggatgaccc ggagagagaa gtattagagt ggaggtttga     5220

cagccgccta gcatttcatc acatggcccg agagctgcat ccggactgta ctgggtctct     5280

ctggttagac cagatctgag cctgggagct ctctggctaa ctagggaacc cactgcttaa     5340

gcctcaataa agcttgcctt gagtgcttca agtagtgtgt gcccgtctgt tgtgtgactc     5400

tggtaactag agatccctca gaccctttta gtcagtgtgg aaaatctcta gcagcatgtg     5460

agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca     5520

taggctccgc ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa     5580

cccgacagga ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc     5640

tgttccgacc ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc     5700

gctttctcat agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct     5760

gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg     5820

tcttgagtcc aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag     5880

gattagcaga gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta     5940

cggctacact agaagaacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg     6000

aaaaagagtt ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt     6060

tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt     6120

ttctacgggg tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag     6180

attatcaaaa aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat     6240

ctaaagtata tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc     6300

tatctcagcg atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat     6360

aactacgata cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc     6420

acgctcaccg gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag     6480

aagtggtcct gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag     6540

agtaagtagt tcgccagtta atagtttgcg caacgttgtt gccattgcta caggcatcgt     6600

ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg     6660

agttacatga tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt     6720

tgtcagaagt aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc     6780

tcttactgtc atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc     6840

attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa     6900

taccgcgcca catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg     6960

aaaactctca aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc     7020

caactgatct tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag     7080

gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt     7140

cctttttcaa tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt     7200

tgaatgtatt tagaaaaata aacaaatagg ggtcccgcgc acatttcccc gaaaagtgcc     7260

acctgac                                                               7267


<210>  68
<211>  179
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<223>  Alternative 5' LTR Region Lacking Two 3' Residues

<400>  68
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg      120

tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa aatctctag       179


<210>  69
<211>  462
<212>  DNA
<213>  Encephalomyocarditis Virus (EMCV)


<220>
<221>  misc_feature
<222>  (1)..(462)
<223>  Internal Ribosome Entry Site of Encephalomyocarditis Virus (EMCV)

<400>  69
gagggcccgg aaacctggcc ctgtcttctt gacgagcatt cctaggggtc tttcccctct       60

cgccaaagga atgcaaggtc tgttgaatgt cgtgaaggaa gcagttcctc tggaagcttc      120

ttgaagacaa acaacgtctg tagcgaccct ttgcaggcag cggaaccccc cacctggcga      180

caggtgcctc tgcggccaaa agccacgtgt ataagataca cctgcaaagg cggcacaacc      240

ccagtgccac gttgtgagtt ggatagttgt ggaaagagtc aaatggctct cctcaagcgt      300

attcaacaag gggctgaagg atgcccagaa ggtaccccat tgtatgggat ctgatctggg      360

gcctcggtgc acatgcttta catgtgttta gtcgaggtta aaaaacgtct aggccccccg      420

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aa                         462


<210>  70
<211>  11060
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLenti-CMV-IRES-Spike (-att) Vector

<400>  70
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat cgcgttgaca      240

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagcgcg ttttgcctgt actgggtctc      840

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      900

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      960

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct aggtggcgcc     1020

cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc     1080

ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt     1140

tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga     1200

gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat     1260

taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt     1320

tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag     1380

gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa     1440

ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa     1500

gtaagaccac cgcacagcaa gcggccggcc gctgatcttc agacctggag gaggagatat     1560

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1620

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1680

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat     1740

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1800

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1860

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1920

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1980

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     2040

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     2100

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     2160

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     2220

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     2280

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     2340

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat cggcactgcg     2400

tgcgccaatt ctgcagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga     2460

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta     2520

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca     2580

gagatccagt ttggttagta ccgggcccgc tctagacatg tccaatatga ccgccatgtt     2640

gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc     2700

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     2760

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     2820

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     2880

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     2940

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat     3000

tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc     3060

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     3120

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa     3180

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     3240

agaattttgt aatacgactc actatagggc ggccgggaat tcgtcgactg cccccccccc     3300

taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt     3360

ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt     3420

gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt     3480

cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct     3540

ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt     3600

ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt     3660

ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa     3720

ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta     3780

gtcgaggtta aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa     3840

acacgatgat aatgatccgg taccgaggag atctgccgcc gcgatcgcca ccatgtacag     3900

gatgcaactc ctgtcttgca ttgcactaag tcttgcactt gtcacaaaca gtatgtttgt     3960

gttcctggtg ctgctgccac tggtgtccag ccagtgtgtg aacctgacca ccaggaccca     4020

acttcctcct gcctacacca actccttcac caggggagtc tactaccctg acaaggtgtt     4080

caggtcctct gtgctgcaca gcacccagga cctgttcctg ccattcttca gcaatgtgac     4140

ctggttccat gccatccatg tgtctggcac caatggcacc aagaggtttg acaaccctgt     4200

gctgccattc aatgatggag tctactttgc cagcacagag aagagcaaca tcatcagggg     4260

ctggattttt ggcaccaccc tggacagcaa gacccagtcc ctgctgattg tgaacaatgc     4320

caccaatgtg gtgattaagg tgtgtgagtt ccagttctgt aatgacccat tcctgggagt     4380

ctactaccac aagaacaaca agtcctggat ggagtctgag ttcagggtct actcctctgc     4440

caacaactgt acctttgaat atgtgagcca accattcctg atggacttgg agggcaagca     4500

gggcaacttc aagaacctga gggagtttgt gttcaagaac attgatggct acttcaagat     4560

ttacagcaaa cacacaccaa tcaacctggt gagggacctg ccacagggct tctctgcctt     4620

ggaaccactg gtggacctgc caattggcat caacatcacc aggttccaga ccctgctggc     4680

tctgcacagg tcctacctga cacctggaga ctcctcctct ggctggacag caggagcagc     4740

agcctactat gtgggctacc tccaaccaag gaccttcctg ctgaaataca atgagaatgg     4800

caccatcaca gatgctgtgg actgtgccct ggacccactg tctgagacca agtgtaccct     4860

gaaatccttc acagtggaga agggcatcta ccagaccagc aacttcaggg tccaaccaac     4920

agagagcatt gtgaggtttc caaacatcac caacctgtgt ccatttggag aggtgttcaa     4980

tgccaccagg tttgcctctg tctatgcctg gaacaggaag aggattagca actgtgtggc     5040

tgactactct gtgctctaca actctgcctc cttcagcacc ttcaagtgtt atggagtgag     5100

cccaaccaaa ctgaatgacc tgtgtttcac caatgtctat gctgactcct ttgtgattag     5160

gggagatgag gtgagacaga ttgcccctgg acaaacaggc aagattgctg actacaacta     5220

caaactgcct gatgacttca caggctgtgt gattgcctgg aacagcaaca acctggacag     5280

caaggtggga ggcaactaca actacctcta cagactgttc aggaagagca acctgaaacc     5340

atttgagagg gacatcagca cagagattta ccaggctggc agcacaccat gtaatggagt     5400

ggagggcttc aactgttact ttccactcca atcctatggc ttccaaccaa ccaatggagt     5460

gggctaccaa ccatacaggg tggtggtgct gtcctttgaa ctgctccatg cccctgccac     5520

agtgtgtgga ccaaagaaga gcaccaacct ggtgaagaac aagtgtgtga acttcaactt     5580

caatggactg acaggcacag gagtgctgac agagagcaac aagaagttcc tgccattcca     5640

acagtttggc agggacattg ctgacaccac agatgctgtg agggacccac agaccttgga     5700

gattctggac atcacaccat gttcctttgg aggagtgtct gtgattacac ctggcaccaa     5760

caccagcaac caggtggctg tgctctacca ggatgtgaac tgtactgagg tgcctgtggc     5820

tatccatgct gaccaactta caccaacctg gagggtctac agcacaggca gcaatgtgtt     5880

ccagaccagg gctggctgtc tgattggagc agagcatgtg aacaactcct atgagtgtga     5940

catcccaatt ggagcaggca tctgtgcctc ctaccagacc cagaccaaca gcccaaggag     6000

ggcaaggtct gtggcaagcc agagcatcat tgcctacaca atgagtctgg gagcagagaa     6060

ctctgtggct tacagcaaca acagcattgc catcccaacc aacttcacca tctctgtgac     6120

cacagagatt ctgcctgtga gtatgaccaa gacctctgtg gactgtacaa tgtatatctg     6180

tggagacagc acagagtgta gcaacctgct gctccaatat ggctccttct gtacccaact     6240

taacagggct ctgacaggca ttgctgtgga acaggacaag aacacccagg aggtgtttgc     6300

ccaggtgaag cagatttaca agacacctcc aatcaaggac tttggaggct tcaacttcag     6360

ccagattctg cctgacccaa gcaagccaag caagaggtcc ttcattgagg acctgctgtt     6420

caacaaggtg accctggctg atgctggctt catcaagcaa tatggagact gtctgggaga     6480

cattgctgcc agggacctga tttgtgccca gaagttcaat ggactgacag tgctgcctcc     6540

actgctgaca gatgagatga ttgcccaata cacctctgcc ctgctggctg gcaccatcac     6600

ctctggctgg acctttggag caggagcagc cctccaaatc ccatttgcta tgcagatggc     6660

ttacaggttc aatggcattg gagtgaccca gaatgtgctc tatgagaacc agaaactgat     6720

tgccaaccag ttcaactctg ccattggcaa gattcaggac tccctgtcca gcacagcctc     6780

tgccctgggc aaactccaag atgtggtgaa ccagaatgcc caggctctga acaccctggt     6840

gaagcaactt tccagcaact ttggagccat ctcctctgtg ctgaatgaca tcctgagcag     6900

actggacaag gtggaggctg aggtccagat tgacagactg attacaggca gactccaatc     6960

cctccaaacc tatgtgaccc aacaacttat cagggctgct gagattaggg catctgccaa     7020

cctggctgcc accaagatga gtgagtgtgt gctgggacaa agcaagaggg tggacttctg     7080

tggcaagggc taccacctga tgagttttcc acagtctgcc cctcatggag tggtgttcct     7140

gcatgtgacc tatgtgcctg cccaggagaa gaacttcacc acagcccctg ccatctgcca     7200

tgatggcaag gctcactttc caagggaggg agtgtttgtg agcaatggca cccactggtt     7260

tgtgacccag aggaacttct atgaaccaca gattatcacc acagacaaca cctttgtgtc     7320

tggcaactgt gatgtggtga ttggcattgt gaacaacaca gtctatgacc cactccaacc     7380

tgaactggac tccttcaagg aggaactgga caaatacttc aagaaccaca ccagccctga     7440

tgtggacctg ggagacatct ctggcatcaa tgcctctgtg gtgaacatcc agaaggagat     7500

tgacagactg aatgaggtgg ctaagaacct gaatgagtcc ctgattgacc tccaagaact     7560

gggcaaatat gaacaataca tcaagtggcc atggtacatc tggctgggct tcattgctgg     7620

actgattgcc attgtgatgg tgaccataat gctgtgttgt atgacctcct gttgttcctg     7680

tctgaaaggc tgttgttcct gtggctcctg ttgtaagtga acgcgtacgc ggccgctcga     7740

gcagaaactc atctcagaag aggatctggc agcaaatgat atcctggatt acaaggatga     7800

cgacgataag gtttaaacgg ccggccgcgg tctgtacaag taggattcgt cgagggacct     7860

aataacttcg tatagcatac attatacgaa gttatacatg tttaagggtt ccggttccac     7920

taggtacaat tcgatatcaa gcttatcgat aatcaacctc tggattacaa aatttgtgaa     7980

agattgactg gtattcttaa ctatgttgct ccttttacgc tatgtggata cgctgcttta     8040

atgcctttgt atcatgctat tgcttcccgt atggctttca ttttctcctc cttgtataaa     8100

tcctggttgc tgtctcttta tgaggagttg tggcccgttg tcaggcaacg tggcgtggtg     8160

tgcactgtgt ttgctgacgc aacccccact ggttggggca ttgccaccac ctgtcagctc     8220

ctttccggga ctttcgcttt ccccctccct attgccacgg cggaactcat cgccgcctgc     8280

cttgcccgct gctggacagg ggctcggctg ttgggcactg acaattccgt ggtgttgtcg     8340

gggaaatcat cgtcctttcc ttggctgctc gcctgtgttg ccacctggat tctgcgcggg     8400

acgtccttct gctacgtccc ttcggccctc aatccagcgg accttccttc ccgcggcctg     8460

ctgccggctc tgcggcctct tccgcgtctt cgccttcgcc ctcagacgag tcggatctcc     8520

ctttgggccg cctccccgca tcgataccgt cgacctcgat cgagacctag aaaaacatgg     8580

agcaatcaca agtagcaata cagcagctac caatgctgat tgtgcctggc tagaagcaca     8640

agaggaggag gaggtgggtt ttccagtcac acctcaggta cctttaagac caatgactta     8700

caaggcagct gtagatctta gccacttttt aaaagaaaag gggggacgaa gggctaattc     8760

actcccaacg aagacaagat ctgcttgatc tgtggatcta ccacacacaa ggctacttcc     8820

ctgattggca gaactacaca ccagggccag ggatcagata tccactgacc tttggatggt     8880

gctacaagct agtaccagtt gagcaagaga aggtagaaga agccaatgaa ggagagaaca     8940

cccgcttgtt acaccctgtg agcctgcatg ggatggatga cccggagaga gaagtattag     9000

agtggaggtt tgacagccgc ctagcatttc atcacatggc ccgagagctg catccggact     9060

gtactgggtc tctctggtta gaccagatct gagcctggga gctctctggc taactaggga     9120

acccactgct taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc     9180

tgttgtgtga ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct     9240

ctagcagcat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     9300

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     9360

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     9420

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     9480

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     9540

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     9600

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     9660

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     9720

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     9780

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     9840

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     9900

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     9960

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa    10020

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa    10080

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc    10140

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga    10200

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa    10260

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt    10320

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg    10380

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc    10440

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg    10500

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag    10560

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt    10620

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt    10680

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac    10740

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac    10800

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag    10860

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa    10920

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga    10980

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggtcccg cgcacatttc    11040

cccgaaaagt gccacctgac                                                11060


<210>  71
<211>  3765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized Polynucleotide Encoding SARS-CoV-2 S Protein 
       Lacking Terminal 18 Amino Acid Residues

<400>  71
atgtttgtgt tcctggtgct gctgccactg gtgtccagcc agtgtgtgaa cctgaccacc       60

aggacccaac ttcctcctgc ctacaccaac tccttcacca ggggagtcta ctaccctgac      120

aaggtgttca ggtcctctgt gctgcacagc acccaggacc tgttcctgcc attcttcagc      180

aatgtgacct ggttccatgc catccatgtg tctggcacca atggcaccaa gaggtttgac      240

aaccctgtgc tgccattcaa tgatggagtc tactttgcca gcacagagaa gagcaacatc      300

atcaggggct ggatttttgg caccaccctg gacagcaaga cccagtccct gctgattgtg      360

aacaatgcca ccaatgtggt gattaaggtg tgtgagttcc agttctgtaa tgacccattc      420

ctgggagtct actaccacaa gaacaacaag tcctggatgg agtctgagtt cagggtctac      480

tcctctgcca acaactgtac ctttgaatat gtgagccaac cattcctgat ggacttggag      540

ggcaagcagg gcaacttcaa gaacctgagg gagtttgtgt tcaagaacat tgatggctac      600

ttcaagattt acagcaaaca cacaccaatc aacctggtga gggacctgcc acagggcttc      660

tctgccttgg aaccactggt ggacctgcca attggcatca acatcaccag gttccagacc      720

ctgctggctc tgcacaggtc ctacctgaca cctggagact cctcctctgg ctggacagca      780

ggagcagcag cctactatgt gggctacctc caaccaagga ccttcctgct gaaatacaat      840

gagaatggca ccatcacaga tgctgtggac tgtgccctgg acccactgtc tgagaccaag      900

tgtaccctga aatccttcac agtggagaag ggcatctacc agaccagcaa cttcagggtc      960

caaccaacag agagcattgt gaggtttcca aacatcacca acctgtgtcc atttggagag     1020

gtgttcaatg ccaccaggtt tgcctctgtc tatgcctgga acaggaagag gattagcaac     1080

tgtgtggctg actactctgt gctctacaac tctgcctcct tcagcacctt caagtgttat     1140

ggagtgagcc caaccaaact gaatgacctg tgtttcacca atgtctatgc tgactccttt     1200

gtgattaggg gagatgaggt gagacagatt gcccctggac aaacaggcaa gattgctgac     1260

tacaactaca aactgcctga tgacttcaca ggctgtgtga ttgcctggaa cagcaacaac     1320

ctggacagca aggtgggagg caactacaac tacctctaca gactgttcag gaagagcaac     1380

ctgaaaccat ttgagaggga catcagcaca gagatttacc aggctggcag cacaccatgt     1440

aatggagtgg agggcttcaa ctgttacttt ccactccaat cctatggctt ccaaccaacc     1500

aatggagtgg gctaccaacc atacagggtg gtggtgctgt cctttgaact gctccatgcc     1560

cctgccacag tgtgtggacc aaagaagagc accaacctgg tgaagaacaa gtgtgtgaac     1620

ttcaacttca atggactgac aggcacagga gtgctgacag agagcaacaa gaagttcctg     1680

ccattccaac agtttggcag ggacattgct gacaccacag atgctgtgag ggacccacag     1740

accttggaga ttctggacat cacaccatgt tcctttggag gagtgtctgt gattacacct     1800

ggcaccaaca ccagcaacca ggtggctgtg ctctaccagg atgtgaactg tactgaggtg     1860

cctgtggcta tccatgctga ccaacttaca ccaacctgga gggtctacag cacaggcagc     1920

aatgtgttcc agaccagggc tggctgtctg attggagcag agcatgtgaa caactcctat     1980

gagtgtgaca tcccaattgg agcaggcatc tgtgcctcct accagaccca gaccaacagc     2040

ccaaggaggg caaggtctgt ggcaagccag agcatcattg cctacacaat gagtctggga     2100

gcagagaact ctgtggctta cagcaacaac agcattgcca tcccaaccaa cttcaccatc     2160

tctgtgacca cagagattct gcctgtgagt atgaccaaga cctctgtgga ctgtacaatg     2220

tatatctgtg gagacagcac agagtgtagc aacctgctgc tccaatatgg ctccttctgt     2280

acccaactta acagggctct gacaggcatt gctgtggaac aggacaagaa cacccaggag     2340

gtgtttgccc aggtgaagca gatttacaag acacctccaa tcaaggactt tggaggcttc     2400

aacttcagcc agattctgcc tgacccaagc aagccaagca agaggtcctt cattgaggac     2460

ctgctgttca acaaggtgac cctggctgat gctggcttca tcaagcaata tggagactgt     2520

ctgggagaca ttgctgccag ggacctgatt tgtgcccaga agttcaatgg actgacagtg     2580

ctgcctccac tgctgacaga tgagatgatt gcccaataca cctctgccct gctggctggc     2640

accatcacct ctggctggac ctttggagca ggagcagccc tccaaatccc atttgctatg     2700

cagatggctt acaggttcaa tggcattgga gtgacccaga atgtgctcta tgagaaccag     2760

aaactgattg ccaaccagtt caactctgcc attggcaaga ttcaggactc cctgtccagc     2820

acagcctctg ccctgggcaa actccaagat gtggtgaacc agaatgccca ggctctgaac     2880

accctggtga agcaactttc cagcaacttt ggagccatct cctctgtgct gaatgacatc     2940

ctgagcagac tggacaaggt ggaggctgag gtccagattg acagactgat tacaggcaga     3000

ctccaatccc tccaaaccta tgtgacccaa caacttatca gggctgctga gattagggca     3060

tctgccaacc tggctgccac caagatgagt gagtgtgtgc tgggacaaag caagagggtg     3120

gacttctgtg gcaagggcta ccacctgatg agttttccac agtctgcccc tcatggagtg     3180

gtgttcctgc atgtgaccta tgtgcctgcc caggagaaga acttcaccac agcccctgcc     3240

atctgccatg atggcaaggc tcactttcca agggagggag tgtttgtgag caatggcacc     3300

cactggtttg tgacccagag gaacttctat gaaccacaga ttatcaccac agacaacacc     3360

tttgtgtctg gcaactgtga tgtggtgatt ggcattgtga acaacacagt ctatgaccca     3420

ctccaacctg aactggactc cttcaaggag gaactggaca aatacttcaa gaaccacacc     3480

agccctgatg tggacctggg agacatctct ggcatcaatg cctctgtggt gaacatccag     3540

aaggagattg acagactgaa tgaggtggct aagaacctga atgagtccct gattgacctc     3600

caagaactgg gcaaatatga acaatacatc aagtggccat ggtacatctg gctgggcttc     3660

attgctggac tgattgccat tgtgatggtg accataatgc tgtgttgtat gacctcctgt     3720

tgttcctgtc tgaaaggctg ttgttcctgt ggctcctgtt gtaag                     3765


<210>  72
<211>  20
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(20)
<223>  IL-2 Signal Sequence

<400>  72

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  73
<211>  60
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(60)
<223>  Polynucleotide Encoding IL-2 Signal Sequence

<400>  73
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60


<210>  74
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Polynucleotide Complementary to Polynucleotide That Encodes a 
       Tetracysteine Peptide

<400>  74
gcaacaacct ggacagca                                                     18


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tetracysteine Peptide

<400>  75

Cys Cys Pro Gly Cys Cys 
1               5       


<210>  76
<211>  98
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(98)
<223>  Lentiviral LTR R Region

<400>  76
gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact agggaaccca       60

ctgcttaagc ctcaataaag cttgccttga gtgcttca                               98


<210>  77
<211>  83
<212>  DNA
<213>  Lentivirus


<220>
<221>  misc_feature
<222>  (1)..(83)
<223>  Lentiviral U5 LTR Region

<400>  77
agtagtgtgt gcccgtctgt tgtgtgactc tggtaactag agatccctca gaccctttta       60

gtcagtgtgg aaaatctcta gca                                               83


<210>  78
<211>  419
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(419)
<223>  SARS-CoV-2 Nucleocapsid (N) Protein

<400>  78

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     


Thr Gln Ala 
            


<210>  79
<211>  1257
<212>  DNA
<213>  SARS-CoV-2


<220>
<221>  misc_feature
<222>  (1)..(1257)
<223>  Polynucleotide Encoding SARS-CoV-2 Nucleocapsid (N) Protein

<400>  79
atgtctgata atggacccca aaatcagcga aatgcacccc gcattacgtt tggtggaccc       60

tcagattcaa ctggcagtaa ccagaatgga gaacgcagtg gggcgcgatc aaaacaacgt      120

cggccccaag gtttacccaa taatactgcg tcttggttca ccgctctcac tcaacatggc      180

aaggaagacc ttaaattccc tcgaggacaa ggcgttccaa ttaacaccaa tagcagtcca      240

gatgaccaaa ttggctacta ccgaagagct accagacgaa ttcgtggtgg tgacggtaaa      300

atgaaagatc tcagtccaag atggtatttc tactacctag gaactgggcc agaagctgga      360

cttccctatg gtgctaacaa agacggcatc atatgggttg caactgaggg agccttgaat      420

acaccaaaag atcacattgg cacccgcaat cctgctaaca atgctgcaat cgtgctacaa      480

cttcctcaag gaacaacatt gccaaaaggc ttctacgcag aagggagcag aggcggcagt      540

caagcctctt ctcgttcctc atcacgtagt cgcaacagtt caagaaattc aactccaggc      600

agcagtaggg gaacttctcc tgctagaatg gctggcaatg gcggtgatgc tgctcttgct      660

ttgctgctgc ttgacagatt gaaccagctt gagagcaaaa tgtctggtaa aggccaacaa      720

caacaaggcc aaactgtcac taagaaatct gctgctgagg cttctaagaa gcctcggcaa      780

aaacgtactg ccactaaagc atacaatgta acacaagctt tcggcagacg tggtccagaa      840

caaacccaag gaaattttgg ggaccaggaa ctaatcagac aaggaactga ttacaaacat      900

tggccgcaaa ttgcacaatt tgcccccagc gcttcagcgt tcttcggaat gtcgcgcatt      960

ggcatggaag tcacaccttc gggaacgtgg ttgacctaca caggtgccat caaattggat     1020

gacaaagatc caaatttcaa agatcaagtc attttgctga ataagcatat tgacgcatac     1080

aaaacattcc caccaacaga gcctaaaaag gacaaaaaga agaaggctga tgaaactcaa     1140

gccttaccgc agagacagaa gaaacagcaa actgtgactc ttcttcctgc tgcagatttg     1200

gatgatttct ccaaacaatt gcaacaatcc atgagcagtg ctgactcaac tcaggcc        1257


<210>  80
<211>  1257
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized Polynucleotide Encoding SARS-CoV-2 Nucleocapsid 
       (N) Protein

<400>  80
atgtctgata atggaccaca aaaccagcgc aatgctccga ggataacatt cggtgggccc       60

tccgactcta ctggaagcaa tcaaaatggg gagcggtcag gagccaggtc taaacagagg      120

cgacctcagg ggctgcctaa taatactgcc agctggttca ctgctctgac ccagcatggc      180

aaggaggact tgaagttccc caggggtcag ggtgtaccaa tcaacactaa ttcttcccca      240

gacgaccaga ttggttatta cagaagggct acccggagga ttaggggagg ggatggcaag      300

atgaaggatc ttagtccacg ctggtatttt tactaccttg gtacaggacc agaggctgga      360

cttccttatg gagcaaacaa agatggaatc atctgggtgg ccacggaggg agccctcaat      420

accccaaaag accatatcgg gacccggaac cccgccaata atgccgcgat agtactgcaa      480

ttgccccaag ggactactct gccaaaaggc ttttatgcag aagggtctcg aggagggtct      540

caggcctcca gtcgctcatc ttcccggtcc agaaacagca gccggaattc cacacccggg      600

agtagcagag gcactagccc tgcacgaatg gctggcaatg gaggagatgc cgcccttgca      660

ctgctgcttc tggatcgcct gaaccagttg gagtccaaaa tgagtggcaa ggggcagcaa      720

cagcagggcc agacagtcac caagaagtct gccgcagaag cttccaaaaa gccaaggcag      780

aagaggacag caactaaagc ttataacgtg acgcaggctt tcggtaggcg gggaccagaa      840

cagacccagg gtaacttcgg cgatcaggag cttattagac aggggacaga ctataaacac      900

tggccccaga tcgcccaatt tgcccccagt gcatccgcct tcttcgggat gagtagaatc      960

ggcatggagg tgactcctag tggcacgtgg ctcacctata ccggcgctat caagcttgat     1020

gacaaagatc ctaatttcaa agatcaggtc atactgctga ataagcacat tgacgcatac     1080

aaaacctttc cccctaccga accgaagaag gacaagaaga aaaaggccga tgagacgcaa     1140

gctctgcctc agaggcagaa gaaacagcaa acagtcactc tgttgcctgc ggcggacctt     1200

gatgactttt ctaaacagct gcagcagagt atgagcagcg ccgactccac ccaggcg        1257


<210>  81
<211>  22
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  IgGk Signal Sequence

<400>  81

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210>  82
<211>  66
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(66)
<223>  Polynucleotide Encoding IgGk Signal Sequence

<400>  82
atggacatga gggtccctgc tcagctcctg gggctcctgc tgctctggct ctcaggtgcc       60

agatgt                                                                  66


<210>  83
<211>  11381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLenti-IgGkappa-nCoV-Spike-CD8-TM (-att) Vector

<400>  83
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat cgcgttgaca      240

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagcgcg ttttgcctgt actgggtctc      840

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      900

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      960

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct aggtggcgcc     1020

cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc     1080

ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt     1140

tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga     1200

gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat     1260

taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt     1320

tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag     1380

gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa     1440

ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa     1500

gtaagaccac cgcacagcaa gcggccggcc gctgatcttc agacctggag gaggagatat     1560

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1620

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1680

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat     1740

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1800

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1860

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1920

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1980

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     2040

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     2100

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     2160

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     2220

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     2280

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     2340

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat cggcactgcg     2400

tgcgccaatt ctgcagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga     2460

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta     2520

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca     2580

gagatccagt ttggttagta ccgggcccgc tctagacatg tccaatatga ccgccatgtt     2640

gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc     2700

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     2760

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     2820

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     2880

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     2940

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat     3000

tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc     3060

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     3120

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa     3180

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     3240

agaattttgt aatacgactc actatagggc ggccgggaat tcgtcgactg cccccccccc     3300

taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt     3360

ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt     3420

gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt     3480

cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct     3540

ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt     3600

ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt     3660

ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa     3720

ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta     3780

gtcgaggtta aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa     3840

acacgatgat aatgatccgg taccgaggag atctgccgcc gcgatcgcca ccatggacat     3900

gagggtccct gctcagctcc tggggctcct gctgctctgg ctctcaggtg ccagatgtat     3960

gtttgtgttc ctggtgctgc tgccactggt gtccagccag tgtgtgaacc tgaccaccag     4020

gacccaactt cctcctgcct acaccaactc cttcaccagg ggagtctact accctgacaa     4080

ggtgttcagg tcctctgtgc tgcacagcac ccaggacctg ttcctgccat tcttcagcaa     4140

tgtgacctgg ttccatgcca tccatgtgtc tggcaccaat ggcaccaaga ggtttgacaa     4200

ccctgtgctg ccattcaatg atggagtcta ctttgccagc acagagaaga gcaacatcat     4260

caggggctgg atttttggca ccaccctgga cagcaagacc cagtccctgc tgattgtgaa     4320

caatgccacc aatgtggtga ttaaggtgtg tgagttccag ttctgtaatg acccattcct     4380

gggagtctac taccacaaga acaacaagtc ctggatggag tctgagttca gggtctactc     4440

ctctgccaac aactgtacct ttgaatatgt gagccaacca ttcctgatgg acttggaggg     4500

caagcagggc aacttcaaga acctgaggga gtttgtgttc aagaacattg atggctactt     4560

caagatttac agcaaacaca caccaatcaa cctggtgagg gacctgccac agggcttctc     4620

tgccttggaa ccactggtgg acctgccaat tggcatcaac atcaccaggt tccagaccct     4680

gctggctctg cacaggtcct acctgacacc tggagactcc tcctctggct ggacagcagg     4740

agcagcagcc tactatgtgg gctacctcca accaaggacc ttcctgctga aatacaatga     4800

gaatggcacc atcacagatg ctgtggactg tgccctggac ccactgtctg agaccaagtg     4860

taccctgaaa tccttcacag tggagaaggg catctaccag accagcaact tcagggtcca     4920

accaacagag agcattgtga ggtttccaaa catcaccaac ctgtgtccat ttggagaggt     4980

gttcaatgcc accaggtttg cctctgtcta tgcctggaac aggaagagga ttagcaactg     5040

tgtggctgac tactctgtgc tctacaactc tgcctccttc agcaccttca agtgttatgg     5100

agtgagccca accaaactga atgacctgtg tttcaccaat gtctatgctg actcctttgt     5160

gattagggga gatgaggtga gacagattgc ccctggacaa acaggcaaga ttgctgacta     5220

caactacaaa ctgcctgatg acttcacagg ctgtgtgatt gcctggaaca gcaacaacct     5280

ggacagcaag gtgggaggca actacaacta cctctacaga ctgttcagga agagcaacct     5340

gaaaccattt gagagggaca tcagcacaga gatttaccag gctggcagca caccatgtaa     5400

tggagtggag ggcttcaact gttactttcc actccaatcc tatggcttcc aaccaaccaa     5460

tggagtgggc taccaaccat acagggtggt ggtgctgtcc tttgaactgc tccatgcccc     5520

tgccacagtg tgtggaccaa agaagagcac caacctggtg aagaacaagt gtgtgaactt     5580

caacttcaat ggactgacag gcacaggagt gctgacagag agcaacaaga agttcctgcc     5640

attccaacag tttggcaggg acattgctga caccacagat gctgtgaggg acccacagac     5700

cttggagatt ctggacatca caccatgttc ctttggagga gtgtctgtga ttacacctgg     5760

caccaacacc agcaaccagg tggctgtgct ctaccaggat gtgaactgta ctgaggtgcc     5820

tgtggctatc catgctgacc aacttacacc aacctggagg gtctacagca caggcagcaa     5880

tgtgttccag accagggctg gctgtctgat tggagcagag catgtgaaca actcctatga     5940

gtgtgacatc ccaattggag caggcatctg tgcctcctac cagacccaga ccaacagccc     6000

aaggagggca aggtctgtgg caagccagag catcattgcc tacacaatga gtctgggagc     6060

agagaactct gtggcttaca gcaacaacag cattgccatc ccaaccaact tcaccatctc     6120

tgtgaccaca gagattctgc ctgtgagtat gaccaagacc tctgtggact gtacaatgta     6180

tatctgtgga gacagcacag agtgtagcaa cctgctgctc caatatggct ccttctgtac     6240

ccaacttaac agggctctga caggcattgc tgtggaacag gacaagaaca cccaggaggt     6300

gtttgcccag gtgaagcaga tttacaagac acctccaatc aaggactttg gaggcttcaa     6360

cttcagccag attctgcctg acccaagcaa gccaagcaag aggtccttca ttgaggacct     6420

gctgttcaac aaggtgaccc tggctgatgc tggcttcatc aagcaatatg gagactgtct     6480

gggagacatt gctgccaggg acctgatttg tgcccagaag ttcaatggac tgacagtgct     6540

gcctccactg ctgacagatg agatgattgc ccaatacacc tctgccctgc tggctggcac     6600

catcacctct ggctggacct ttggagcagg agcagccctc caaatcccat ttgctatgca     6660

gatggcttac aggttcaatg gcattggagt gacccagaat gtgctctatg agaaccagaa     6720

actgattgcc aaccagttca actctgccat tggcaagatt caggactccc tgtccagcac     6780

agcctctgcc ctgggcaaac tccaagatgt ggtgaaccag aatgcccagg ctctgaacac     6840

cctggtgaag caactttcca gcaactttgg agccatctcc tctgtgctga atgacatcct     6900

gagcagactg gacaaggtgg aggctgaggt ccagattgac agactgatta caggcagact     6960

ccaatccctc caaacctatg tgacccaaca acttatcagg gctgctgaga ttagggcatc     7020

tgccaacctg gctgccacca agatgagtga gtgtgtgctg ggacaaagca agagggtgga     7080

cttctgtggc aagggctacc acctgatgag ttttccacag tctgcccctc atggagtggt     7140

gttcctgcat gtgacctatg tgcctgccca ggagaagaac ttcaccacag cccctgccat     7200

ctgccatgat ggcaaggctc actttccaag ggagggagtg tttgtgagca atggcaccca     7260

ctggtttgtg acccagagga acttctatga accacagatt atcaccacag acaacacctt     7320

tgtgtctggc aactgtgatg tggtgattgg cattgtgaac aacacagtct atgacccact     7380

ccaacctgaa ctggactcct tcaaggagga actggacaaa tacttcaaga accacaccag     7440

ccctgatgtg gacctgggag acatctctgg catcaatgcc tctgtggtga acatccagaa     7500

ggagattgac agactgaatg aggtggctaa gaacctgaat gagtccctga ttgacctcca     7560

agaactgggc aaatatgaac aatacatcaa gtggccatgg tacatctggc tgggcttcat     7620

tgctggactg attgccattg tgatggtgac cataatgctg tgttgtatga cctcctgttg     7680

ttcctgtctg aaaggctgtt gttcctgtgg ctcctgttgt aagtttgatg aggatgactc     7740

tgaacctgtg ctgaaaggag tgaaactgca ctacaccgcc ctgagcaact ccatcatgta     7800

cttcagccac ttcgtgccgg tcttcctgcc agcgaagccc accacgacgc cagcgccgcg     7860

accaccaaca ccggcgccca ccatcgcgtc gcagcccctg tccctgcgcc cagaggcgtg     7920

ccggccagcg gcggggggcg cagtgcacac gagggggctg gacttcgcct gtgatatcta     7980

catctgggcg cccttggccg ggacttgtgg ggtccttctc ctgtcactgg ttatcacctg     8040

aacgcgtacg cggccgctcg agcagaaact catctcagaa gaggatctgg cagcaaatga     8100

tatcctggat tacaaggatg acgacgataa ggtttaaacg gccggccgcg gtctgtacaa     8160

gtaggattcg tcgagggacc taataacttc gtatagcata cattatacga agttatacat     8220

gtttaagggt tccggttcca ctaggtacaa ttcgatatca agcttatcga taatcaacct     8280

ctggattaca aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg     8340

ctatgtggat acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc     8400

attttctcct ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt     8460

gtcaggcaac gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc     8520

attgccacca cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg     8580

gcggaactca tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact     8640

gacaattccg tggtgttgtc ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt     8700

gccacctgga ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg     8760

gaccttcctt cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc     8820

cctcagacga gtcggatctc cctttgggcc gcctccccgc atcgataccg tcgacctcga     8880

tcgagaccta gaaaaacatg gagcaatcac aagtagcaat acagcagcta ccaatgctga     8940

ttgtgcctgg ctagaagcac aagaggagga ggaggtgggt tttccagtca cacctcaggt     9000

acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa     9060

ggggggacga agggctaatt cactcccaac gaagacaaga tctgcttgat ctgtggatct     9120

accacacaca aggctacttc cctgattggc agaactacac accagggcca gggatcagat     9180

atccactgac ctttggatgg tgctacaagc tagtaccagt tgagcaagag aaggtagaag     9240

aagccaatga aggagagaac acccgcttgt tacaccctgt gagcctgcat gggatggatg     9300

acccggagag agaagtatta gagtggaggt ttgacagccg cctagcattt catcacatgg     9360

cccgagagct gcatccggac tgtactgggt ctctctggtt agaccagatc tgagcctggg     9420

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc     9480

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct     9540

tttagtcagt gtggaaaatc tctagcagca tgtgagcaaa aggccagcaa aaggccagga     9600

accgtaaaaa ggccgcgttg ctggcgtttt tccataggct ccgcccccct gacgagcatc     9660

acaaaaatcg acgctcaagt cagaggtggc gaaacccgac aggactataa agataccagg     9720

cgtttccccc tggaagctcc ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat     9780

acctgtccgc ctttctccct tcgggaagcg tggcgctttc tcatagctca cgctgtaggt     9840

atctcagttc ggtgtaggtc gttcgctcca agctgggctg tgtgcacgaa ccccccgttc     9900

agcccgaccg ctgcgcctta tccggtaact atcgtcttga gtccaacccg gtaagacacg     9960

acttatcgcc actggcagca gccactggta acaggattag cagagcgagg tatgtaggcg    10020

gtgctacaga gttcttgaag tggtggccta actacggcta cactagaaga acagtatttg    10080

gtatctgcgc tctgctgaag ccagttacct tcggaaaaag agttggtagc tcttgatccg    10140

gcaaacaaac caccgctggt agcggtggtt tttttgtttg caagcagcag attacgcgca    10200

gaaaaaaagg atctcaagaa gatcctttga tcttttctac ggggtctgac gctcagtgga    10260

acgaaaactc acgttaaggg attttggtca tgagattatc aaaaaggatc ttcacctaga    10320

tccttttaaa ttaaaaatga agttttaaat caatctaaag tatatatgag taaacttggt    10380

ctgacagtta ccaatgctta atcagtgagg cacctatctc agcgatctgt ctatttcgtt    10440

catccatagt tgcctgactc cccgtcgtgt agataactac gatacgggag ggcttaccat    10500

ctggccccag tgctgcaatg ataccgcgag acccacgctc accggctcca gatttatcag    10560

caataaacca gccagccgga agggccgagc gcagaagtgg tcctgcaact ttatccgcct    10620

ccatccagtc tattaattgt tgccgggaag ctagagtaag tagttcgcca gttaatagtt    10680

tgcgcaacgt tgttgccatt gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg    10740

cttcattcag ctccggttcc caacgatcaa ggcgagttac atgatccccc atgttgtgca    10800

aaaaagcggt tagctccttc ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt    10860

tatcactcat ggttatggca gcactgcata attctcttac tgtcatgcca tccgtaagat    10920

gcttttctgt gactggtgag tactcaacca agtcattctg agaatagtgt atgcggcgac    10980

cgagttgctc ttgcccggcg tcaatacggg ataataccgc gccacatagc agaactttaa    11040

aagtgctcat cattggaaaa cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt    11100

tgagatccag ttcgatgtaa cccactcgtg cacccaactg atcttcagca tcttttactt    11160

tcaccagcgt ttctgggtga gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa    11220

gggcgacacg gaaatgttga atactcatac tcttcctttt tcaatattat tgaagcattt    11280

atcagggtta ttgtctcatg agcggataca tatttgaatg tatttagaaa aataaacaaa    11340

taggggtccc gcgcacattt ccccgaaaag tgccacctga c                        11381


<210>  84
<211>  8819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pLenti-IgGkappa-nCoV-N-CD8-TM (-att) Vector

<400>  84
gtcgacggat cgggagatct cccgatcccc tatggtgcac tctcagtaca atctgctctg       60

atgccgcata gttaagccag tatctgctcc ctgcttgtgt gttggaggtc gctgagtagt      120

gcgcgagcaa aatttaagct acaacaaggc aaggcttgac cgacaattgc atgaagaatc      180

tgcttagggt taggcgtttt gcgctgcttc gcgatgtacg ggccagatat cgcgttgaca      240

ttgattattg actagttatt aatagtaatc aattacgggg tcattagttc atagcccata      300

tatggagttc cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga      360

cccccgccca ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt      420

ccattgacgt caatgggtgg agtatttacg gtaaactgcc cacttggcag tacatcaagt      480

gtatcatatg ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca      540

ttatgcccag tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt      600

catcgctatt accatggtga tgcggttttg gcagtacatc aatgggcgtg gatagcggtt      660

tgactcacgg ggatttccaa gtctccaccc cattgacgtc aatgggagtt tgttttggca      720

ccaaaatcaa cgggactttc caaaatgtcg taacaactcc gccccattga cgcaaatggg      780

cggtaggcgt gtacggtggg aggtctatat aagcagcgcg ttttgcctgt actgggtctc      840

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      900

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      960

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct aggtggcgcc     1020

cgaacaggga cttgaaagcg aaagggaaac cagaggagct ctctcgacgc aggactcggc     1080

ttgctgaagc gcgcacggca agaggcgagg ggcggcgact ggtgagtacg ccaaaaattt     1140

tgactagcgg aggctagaag gagagagatg ggtgcgagag cgtcagtatt aagcggggga     1200

gaattagatc gcgatgggaa aaaattcggt taaggccagg gggaaagaaa aaatataaat     1260

taaaacatat agtatgggca agcagggagc tagaacgatt cgcagttaat cctggcctgt     1320

tagaaacatc agaaggctgt agacaaatac tgggacagct acaaccatcc cttcagacag     1380

gatcagaaga acttagatca ttatataata cagtagcaac cctctattgt gtgcatcaaa     1440

ggatagagat aaaagacacc aaggaagctt tagacaagat agaggaagag caaaacaaaa     1500

gtaagaccac cgcacagcaa gcggccggcc gctgatcttc agacctggag gaggagatat     1560

gagggacaat tggagaagtg aattatataa atataaagta gtaaaaattg aaccattagg     1620

agtagcaccc accaaggcaa agagaagagt ggtgcagaga gaaaaaagag cagtgggaat     1680

aggagctttg ttccttgggt tcttgggagc agcaggaagc actatgggcg cagcgtcaat     1740

gacgctgacg gtacaggcca gacaattatt gtctggtata gtgcagcagc agaacaattt     1800

gctgagggct attgaggcgc aacagcatct gttgcaactc acagtctggg gcatcaagca     1860

gctccaggca agaatcctgg ctgtggaaag atacctaaag gatcaacagc tcctggggat     1920

ttggggttgc tctggaaaac tcatttgcac cactgctgtg ccttggaatg ctagttggag     1980

taataaatct ctggaacaga tttggaatca cacgacctgg atggagtggg acagagaaat     2040

taacaattac acaagcttaa tacactcctt aattgaagaa tcgcaaaacc agcaagaaaa     2100

gaatgaacaa gaattattgg aattagataa atgggcaagt ttgtggaatt ggtttaacat     2160

aacaaattgg ctgtggtata taaaattatt cataatgata gtaggaggct tggtaggttt     2220

aagaatagtt tttgctgtac tttctatagt gaatagagtt aggcagggat attcaccatt     2280

atcgtttcag acccacctcc caaccccgag gggacccgac aggcccgaag gaatagaaga     2340

agaaggtgga gagagagaca gagacagatc cattcgatta gtgaacggat cggcactgcg     2400

tgcgccaatt ctgcagacaa atggcagtat tcatccacaa ttttaaaaga aaagggggga     2460

ttggggggta cagtgcaggg gaaagaatag tagacataat agcaacagac atacaaacta     2520

aagaattaca aaaacaaatt acaaaaattc aaaattttcg ggtttattac agggacagca     2580

gagatccagt ttggttagta ccgggcccgc tctagacatg tccaatatga ccgccatgtt     2640

gacattgatt attgactagt tattaatagt aatcaattac ggggtcatta gttcatagcc     2700

catatatgga gttccgcgtt acataactta cggtaaatgg cccgcctggc tgaccgccca     2760

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga     2820

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc     2880

aagtgtatca tatgccaagt ccgcccccta ttgacgtcaa tgacggtaaa tggcccgcct     2940

ggcattatgc ccagtacatg accttacggg actttcctac ttggcagtac atctacgtat     3000

tagtcatcgc tattaccatg gtgatgcggt tttggcagta caccaatggg cgtggatagc     3060

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt     3120

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaataa ccccgccccg ttgacgcaaa     3180

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc     3240

agaattttgt aatacgactc actatagggc ggccgggaat tcgtcgactg cccccccccc     3300

taacgttact ggccgaagcc gcttggaata aggccggtgt gcgtttgtct atatgttatt     3360

ttccaccata ttgccgtctt ttggcaatgt gagggcccgg aaacctggcc ctgtcttctt     3420

gacgagcatt cctaggggtc tttcccctct cgccaaagga atgcaaggtc tgttgaatgt     3480

cgtgaaggaa gcagttcctc tggaagcttc ttgaagacaa acaacgtctg tagcgaccct     3540

ttgcaggcag cggaaccccc cacctggcga caggtgcctc tgcggccaaa agccacgtgt     3600

ataagataca cctgcaaagg cggcacaacc ccagtgccac gttgtgagtt ggatagttgt     3660

ggaaagagtc aaatggctct cctcaagcgt attcaacaag gggctgaagg atgcccagaa     3720

ggtaccccat tgtatgggat ctgatctggg gcctcggtgc acatgcttta catgtgttta     3780

gtcgaggtta aaaaacgtct aggccccccg aaccacgggg acgtggtttt cctttgaaaa     3840

acacgatgat aatgatccgg taccgaggag atctgccgcc gcgatcgcca ccatggacat     3900

gagggtccct gctcagctcc tggggctcct gctgctctgg ctctcaggtg ccagatgtat     3960

gtctgataat ggaccccaaa atcagcgaaa tgcaccccgc attacgtttg gtggaccctc     4020

agattcaact ggcagtaacc agaatggaga acgcagtggg gcgcgatcaa aacaacgtcg     4080

gccccaaggt ttacccaata atactgcgtc ttggttcacc gctctcactc aacatggcaa     4140

ggaagacctt aaattccctc gaggacaagg cgttccaatt aacaccaata gcagtccaga     4200

tgaccaaatt ggctactacc gaagagctac cagacgaatt cgtggtggtg acggtaaaat     4260

gaaagatctc agtccaagat ggtatttcta ctacctagga actgggccag aagctggact     4320

tccctatggt gctaacaaag acggcatcat atgggttgca actgagggag ccttgaatac     4380

accaaaagat cacattggca cccgcaatcc tgctaacaat gctgcaatcg tgctacaact     4440

tcctcaagga acaacattgc caaaaggctt ctacgcagaa gggagcagag gcggcagtca     4500

agcctcttct cgttcctcat cacgtagtcg caacagttca agaaattcaa ctccaggcag     4560

cagtagggga acttctcctg ctagaatggc tggcaatggc ggtgatgctg ctcttgcttt     4620

gctgctgctt gacagattga accagcttga gagcaaaatg tctggtaaag gccaacaaca     4680

acaaggccaa actgtcacta agaaatctgc tgctgaggct tctaagaagc ctcggcaaaa     4740

acgtactgcc actaaagcat acaatgtaac acaagctttc ggcagacgtg gtccagaaca     4800

aacccaagga aattttgggg accaggaact aatcagacaa ggaactgatt acaaacattg     4860

gccgcaaatt gcacaatttg cccccagcgc ttcagcgttc ttcggaatgt cgcgcattgg     4920

catggaagtc acaccttcgg gaacgtggtt gacctacaca ggtgccatca aattggatga     4980

caaagatcca aatttcaaag atcaagtcat tttgctgaat aagcatattg acgcatacaa     5040

aacattccca ccaacagagc ctaaaaagga caaaaagaag aaggctgatg aaactcaagc     5100

cttaccgcag agacagaaga aacagcaaac tgtgactctt cttcctgctg cagatttgga     5160

tgatttctcc aaacaattgc aacaatccat gagcagtgct gactcaactc aggccgccct     5220

gagcaactcc atcatgtact tcagccactt cgtgccggtc ttcctgccag cgaagcccac     5280

cacgacgcca gcgccgcgac caccaacacc ggcgcccacc atcgcgtcgc agcccctgtc     5340

cctgcgccca gaggcgtgcc ggccagcggc ggggggcgca gtgcacacga gggggctgga     5400

cttcgcctgt gatatctaca tctgggcgcc cttggccggg acttgtgggg tccttctcct     5460

gtcactggtt atcacctgaa cgcgtacgcg gccgctcgag cagaaactca tctcagaaga     5520

ggatctggca gcaaatgata tcctggatta caaggatgac gacgataagg tttaaacggc     5580

cggccgcggt ctgtacaagt aggattcgtc gagggaccta ataacttcgt atagcataca     5640

ttatacgaag ttatacatgt ttaagggttc cggttccact aggtacaatt cgatatcaag     5700

cttatcgata atcaacctct ggattacaaa atttgtgaaa gattgactgg tattcttaac     5760

tatgttgctc cttttacgct atgtggatac gctgctttaa tgcctttgta tcatgctatt     5820

gcttcccgta tggctttcat tttctcctcc ttgtataaat cctggttgct gtctctttat     5880

gaggagttgt ggcccgttgt caggcaacgt ggcgtggtgt gcactgtgtt tgctgacgca     5940

acccccactg gttggggcat tgccaccacc tgtcagctcc tttccgggac tttcgctttc     6000

cccctcccta ttgccacggc ggaactcatc gccgcctgcc ttgcccgctg ctggacaggg     6060

gctcggctgt tgggcactga caattccgtg gtgttgtcgg ggaaatcatc gtcctttcct     6120

tggctgctcg cctgtgttgc cacctggatt ctgcgcggga cgtccttctg ctacgtccct     6180

tcggccctca atccagcgga ccttccttcc cgcggcctgc tgccggctct gcggcctctt     6240

ccgcgtcttc gccttcgccc tcagacgagt cggatctccc tttgggccgc ctccccgcat     6300

cgataccgtc gacctcgatc gagacctaga aaaacatgga gcaatcacaa gtagcaatac     6360

agcagctacc aatgctgatt gtgcctggct agaagcacaa gaggaggagg aggtgggttt     6420

tccagtcaca cctcaggtac ctttaagacc aatgacttac aaggcagctg tagatcttag     6480

ccacttttta aaagaaaagg ggggacgaag ggctaattca ctcccaacga agacaagatc     6540

tgcttgatct gtggatctac cacacacaag gctacttccc tgattggcag aactacacac     6600

cagggccagg gatcagatat ccactgacct ttggatggtg ctacaagcta gtaccagttg     6660

agcaagagaa ggtagaagaa gccaatgaag gagagaacac ccgcttgtta caccctgtga     6720

gcctgcatgg gatggatgac ccggagagag aagtattaga gtggaggttt gacagccgcc     6780

tagcatttca tcacatggcc cgagagctgc atccggactg tactgggtct ctctggttag     6840

accagatctg agcctgggag ctctctggct aactagggaa cccactgctt aagcctcaat     6900

aaagcttgcc ttgagtgctt caagtagtgt gtgcccgtct gttgtgtgac tctggtaact     6960

agagatccct cagacccttt tagtcagtgt ggaaaatctc tagcagcatg tgagcaaaag     7020

gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc cataggctcc     7080

gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga aacccgacag     7140

gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct cctgttccga     7200

ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg gcgctttctc     7260

atagctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag ctgggctgtg     7320

tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat cgtcttgagt     7380

ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac aggattagca     7440

gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac tacggctaca     7500

ctagaagaac agtatttggt atctgcgctc tgctgaagcc agttaccttc ggaaaaagag     7560

ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt tttgtttgca     7620

agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc ttttctacgg     7680

ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg agattatcaa     7740

aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca atctaaagta     7800

tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca cctatctcag     7860

cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag ataactacga     7920

tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac ccacgctcac     7980

cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc agaagtggtc     8040

ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct agagtaagta     8100

gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc gtggtgtcac     8160

gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg cgagttacat     8220

gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc gttgtcagaa     8280

gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat tctcttactg     8340

tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag tcattctgag     8400

aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat aataccgcgc     8460

cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg cgaaaactct     8520

caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca cccaactgat     8580

cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga aggcaaaatg     8640

ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc ttcctttttc     8700

aatattattg aagcatttat cagggttatt gtctcatgag cggatacata tttgaatgta     8760

tttagaaaaa taaacaaata ggggtcccgc gcacatttcc ccgaaaagtg ccacctgac      8819


<210>  85
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Kozak Consensus Sequence for Strong Initiation of Translation

<400>  85
gccaccatgg                                                              10


<210>  86
<211>  222
<212>  PRT
<213>  SARS-CoV-2


<220>
<221>  MISC_FEATURE
<222>  (1)..(222)
<223>  SARS-CoV-2 ORF5 (M) Protein

<400>  86

Met Ala Asp Ser Asn Gly Thr Ile Thr Val Glu Glu Leu Lys Lys Leu 
1               5                   10                  15      


Leu Glu Gln Trp Asn Leu Val Ile Gly Phe Leu Phe Leu Thr Trp Ile 
            20                  25                  30          


Cys Leu Leu Gln Phe Ala Tyr Ala Asn Arg Asn Arg Phe Leu Tyr Ile 
        35                  40                  45              


Ile Lys Leu Ile Phe Leu Trp Leu Leu Trp Pro Val Thr Leu Ala Cys 
    50                  55                  60                  


Phe Val Leu Ala Ala Val Tyr Arg Ile Asn Trp Ile Thr Gly Gly Ile 
65                  70                  75                  80  


Ala Ile Ala Met Ala Cys Leu Val Gly Leu Met Trp Leu Ser Tyr Phe 
                85                  90                  95      


Ile Ala Ser Phe Arg Leu Phe Ala Arg Thr Arg Ser Met Trp Ser Phe 
            100                 105                 110         


Asn Pro Glu Thr Asn Ile Leu Leu Asn Val Pro Leu His Gly Thr Ile 
        115                 120                 125             


Leu Thr Arg Pro Leu Leu Glu Ser Glu Leu Val Ile Gly Ala Val Ile 
    130                 135                 140                 


Leu Arg Gly His Leu Arg Ile Ala Gly His His Leu Gly Arg Cys Asp 
145                 150                 155                 160 


Ile Lys Asp Leu Pro Lys Glu Ile Thr Val Ala Thr Ser Arg Thr Leu 
                165                 170                 175     


Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp Ser Gly 
            180                 185                 190         


Phe Ala Ala Tyr Ser Arg Tyr Arg Ile Gly Asn Tyr Lys Leu Asn Thr 
        195                 200                 205             


Asp His Ser Ser Ser Ser Asp Asn Ile Ala Leu Leu Val Gln 
    210                 215                 220         


<210>  87
<211>  666
<212>  DNA
<213>  Sars CoV-2


<220>
<221>  misc_feature
<222>  (1)..(666)
<223>  Polynucelotide Encoding SARS-CoV-2 ORF5 (M) Protein

<400>  87
atggcagatt ccaacggtac tattaccgtt gaagagctta aaaagctcct tgaacaatgg       60

aacctagtaa taggtttcct attccttaca tggatttgtc ttctacaatt tgcctatgcc      120

aacaggaata ggtttttgta tataattaag ttaattttcc tctggctgtt atggccagta      180

actttagctt gttttgtgct tgctgctgtt tacagaataa attggatcac cggtggaatt      240

gctatcgcaa tggcttgtct tgtaggcttg atgtggctca gctacttcat tgcttctttc      300

agactgtttg cgcgtacgcg ttccatgtgg tcattcaatc cagaaactaa cattcttctc      360

aacgtgccac tccatggcac tattctgacc agaccgcttc tagaaagtga actcgtaatc      420

ggagctgtga tccttcgtgg acatcttcgt attgctggac accatctagg acgctgtgac      480

atcaaggacc tgcctaaaga aatcactgtt gctacatcac gaacgctttc ttattacaaa      540

ttgggagctt cgcagcgtgt agcaggtgac tcaggttttg ctgcatacag tcgctacagg      600

attggcaact ataaattaaa cacagaccat tccagtagca gtgacaatat tgctttgctt      660

gtacag                                                                 666


<210>  88
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-Optimized Polynucelotide Encosing SARS-CoV-2 ORF5 (M) 
       Protein

<400>  88
atggctgact ctaatggcac catcactgta gaggagctga agaaactctt ggagcagtgg       60

aacctcgtga tcggattcct ttttctgaca tggatctgcc tgctgcagtt cgcttacgcg      120

aacaggaacc gcttcctgta cattatcaag ctgatctttc tgtggcttct ctggccagtg      180

accctggcct gctttgtgct cgcagctgtg tataggatta actggatcac tggaggaatc      240

gcaattgcga tggcctgcct ggttggattg atgtggttgt cctactttat agccagcttc      300

aggctgtttg cccgaacacg gagtatgtgg agctttaacc ccgagaccaa catcctcctg      360

aatgtcccac tgcacggcac catattgacc cgcccgctgc tcgaatctga acttgtgatt      420

ggggctgtta tcctccgggg acatctgcgc atcgctggtc accacctggg cagatgcgac      480

atcaaagatc tcccaaagga gattacagtg gccacgagcc gaactttgag ttattacaag      540

ctcggggctt cacagagagt ggccggggac agcggatttg ccgcgtacag taggtatagg      600

attgggaact ataagctgaa caccgatcat agcagctcct ctgacaatat tgctctgctg      660

gtgcag                                                                 666


