                         SEQUENCE LISTING

<110>  Foghorn Therapeutics Inc.
 
<120>  METHODS OF TREATING CANCERS

<130>  51121-049WO1

<140>  PCT/US20/33829
<141>  2020-05-20

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  5589
<212>  RNA
<213>  Homo sapiens

<400>  1
ggcgggggag gcgccgggaa gtcgacggcg ccggcggctc ctgcaggagg ccactgtctg       60

cagctcccgt gaagatgtcc actccagacc cacccctggg cggaactcct cggccaggtc      120

cttccccggg ccctggccct tcccctggag ccatgctggg ccctagcccg ggtccctcgc      180

cgggctccgc ccacagcatg atggggccca gcccagggcc gccctcagca ggacacccca      240

tccccaccca ggggcctgga gggtaccctc aggacaacat gcaccagatg cacaagccca      300

tggagtccat gcatgagaag ggcatgtcgg acgacccgcg ctacaaccag atgaaaggaa      360

tggggatgcg gtcagggggc catgctggga tggggccccc gcccagcccc atggaccagc      420

actcccaagg ttacccctcg cccctgggtg gctctgagca tgcctctagt ccagttccag      480

ccagtggccc gtcttcgggg ccccagatgt cttccgggcc aggaggtgcc ccgctggatg      540

gtgctgaccc ccaggccttg gggcagcaga accggggccc aaccccattt aaccagaacc      600

agctgcacca gctcagagct cagatcatgg cctacaagat gctggccagg gggcagcccc      660

tccccgacca cctgcagatg gcggtgcagg gcaagcggcc gatgcccggg atgcagcagc      720

agatgccaac gctacctcca ccctcggtgt ccgcaacagg acccggccct ggccctggcc      780

ctggccccgg cccgggtccc ggcccggcac ctccaaatta cagcaggcct catggtatgg      840

gagggcccaa catgcctccc ccaggaccct cgggcgtgcc ccccgggatg ccaggccagc      900

ctcctggagg gcctcccaag ccctggcctg aaggacccat ggcgaatgct gctgccccca      960

cgagcacccc tcagaagctg attcccccgc agccaacggg ccgcccttcc cccgcgcccc     1020

ctgccgtccc acccgccgcc tcgcccgtga tgccaccgca gacccagtcc cccgggcagc     1080

cggcccagcc cgcgcccatg gtgccactgc accagaagca gagccgcatc acccccatcc     1140

agaagccgcg gggcctcgac cctgtggaga tcctgcagga gcgcgagtac aggctgcagg     1200

ctcgcatcgc acaccgaatt caggaacttg aaaaccttcc cgggtccctg gccggggatt     1260

tgcgaaccaa agcgaccatt gagctcaagg ccctcaggct gctgaacttc cagaggcagc     1320

tgcgccagga ggtggtggtg tgcatgcgga gggacacagc gctggagaca gccctcaatg     1380

ctaaggccta caagcgcagc aagcgccagt ccctgcgcga ggcccgcatc actgagaagc     1440

tggagaagca gcagaagatc gagcaggagc gcaagcgccg gcagaagcac caggaatacc     1500

tcaatagcat tctccagcat gccaaggatt tcaaggaata tcacagatcc gtcacaggca     1560

aaatccagaa gctgaccaag gcagtggcca cgtaccatgc caacacggag cgggagcaga     1620

agaaagagaa cgagcggatc gagaaggagc gcatgcggag gctcatggct gaagatgagg     1680

aggggtaccg caagctcatc gaccagaaga aggacaagcg cctggcctac ctcttgcagc     1740

agacagacga gtacgtggct aacctcacgg agctggtgcg gcagcacaag gctgcccagg     1800

tcgccaagga gaaaaagaag aaaaagaaaa agaagaaggc agaaaatgca gaaggacaga     1860

cgcctgccat tgggccggat ggcgagcctc tggacgagac cagccagatg agcgacctcc     1920

cggtgaaggt gatccacgtg gagagtggga agatcctcac aggcacagat gcccccaaag     1980

ccgggcagct ggaggcctgg ctcgagatga acccggggta tgaagtagct ccgaggtctg     2040

atagtgaaga aagtggctca gaagaagagg aagaggagga ggaggaagag cagccgcagg     2100

cagcacagcc tcccaccctg cccgtggagg agaagaagaa gattccagat ccagacagcg     2160

atgacgtctc tgaggtggac gcgcggcaca tcattgagaa tgccaagcaa gatgtcgatg     2220

atgaatatgg cgtgtcccag gcccttgcac gtggcctgca gtcctactat gccgtggccc     2280

atgctgtcac tgagagagtg gacaagcagt cagcgcttat ggtcaatggt gtcctcaaac     2340

agtaccagat caaaggtttg gagtggctgg tgtccctgta caacaacaac ctgaacggca     2400

tcctggccga cgagatgggc ctggggaaga ccatccagac catcgcgctc atcacgtacc     2460

tcatggagca caaacgcatc aatgggccct tcctcatcat cgtgcctctc tcaacgctgt     2520

ccaactgggc gtacgagttt gacaagtggg ccccctccgt ggtgaaggtg tcttacaagg     2580

gatccccagc agcaagacgg gcctttgtcc cccagctccg gagtgggaag ttcaacgtct     2640

tgctgacgac gtacgagtac atcatcaaag acaagcacat cctcgccaag atccgttgga     2700

agtacatgat tgtggacgaa ggtcaccgca tgaagaacca ccactgcaag ctgacgcagg     2760

tgctcaacac gcactatgtg gcaccccgcc gcctgctgct gacgggcaca ccgctgcaga     2820

acaagcttcc cgagctctgg gcgctgctca acttcctgct gcccaccatc ttcaagagct     2880

gcagcacctt cgagcagtgg tttaacgcac cctttgccat gaccggggaa aaggtggacc     2940

tgaatgagga ggaaaccatt ctcatcatcc ggcgtctcca caaagtgctg cggcccttct     3000

tgctccgacg actcaagaag gaagtcgagg cccagttgcc cgaaaaggtg gagtacgtca     3060

tcaagtgcga catgtctgcg ctgcagcgag tgctctaccg ccacatgcag gccaagggcg     3120

tgctgctgac tgatggctcc gagaaggaca agaagggcaa aggcggcacc aagaccctga     3180

tgaacaccat catgcagctg cggaagatct gcaaccaccc ctacatgttc cagcacatcg     3240

aggagtcctt ttccgagcac ttggggttca ctggcggcat tgtccaaggg ctggacctgt     3300

accgagcctc gggtaaattt gagcttcttg atagaattct tcccaaactc cgagcaacca     3360

accacaaagt gctgctgttc tgccaaatga cctccctcat gaccatcatg gaagattact     3420

ttgcgtatcg cggctttaaa tacctcaggc ttgatggaac cacgaaggcg gaggaccggg     3480

gcatgctgct gaaaaccttc aacgagcccg gctctgagta cttcatcttc ctgctcagca     3540

cccgggctgg ggggctcggc ctgaacctcc agtcggcaga cactgtgatc atttttgaca     3600

gcgactggaa tcctcaccag gacctgcaag cgcaggaccg agcccaccgc atcgggcagc     3660

agaacgaggt gcgtgtgctc cgcctctgca ccgtcaacag cgtggaggag aagatcctag     3720

ctgcagccaa gtacaagctc aacgtggacc agaaggtgat ccaggccggc atgttcgacc     3780

agaagtcctc cagccatgag cggcgcgcct tcctgcaggc catcctggag cacgaggagc     3840

aggatgagag cagacactgc agcacgggca gcggcagtgc cagcttcgcc cacactgccc     3900

ctccgccagc gggcgtcaac cccgacttgg aggagccacc tctaaaggag gaagacgagg     3960

tgcccgacga cgagaccgtc aaccagatga tcgcccggca cgaggaggag tttgatctgt     4020

tcatgcgcat ggacctggac cgcaggcgcg aggaggcccg caaccccaag cggaagccgc     4080

gcctcatgga ggaggacgag ctcccctcgt ggatcatcaa ggacgacgcg gaggtggagc     4140

ggctgacctg tgaggaggag gaggagaaga tgttcggccg tggctcccgc caccgcaagg     4200

aggtggacta cagcgactca ctgacggaga agcagtggct caagaaaatt acaggaaaag     4260

atatccatga cacagccagc agtgtggcac gtgggctaca attccagcgt ggccttcagt     4320

tctgcacacg tgcgtcaaag gccatcgagg agggcacgct ggaggagatc gaagaggagg     4380

tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc tcctccaccc     4440

cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag aagaagcgcg     4500

ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag aagatgaaga     4560

agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag ctcagcgagg     4620

tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc atccgcaagc     4680

ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc agcctcaacg     4740

acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac ctggagggct     4800

ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg cggcagaaaa     4860

tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag ggcgaggagg     4920

aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc cggaaggaga     4980

aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc cgagccaagc     5040

cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca ggaagtggca     5100

gcgaagaaga ctgagccccg acattccagt ctcgaccccg agcccctcgt tccagagctg     5160

agatggcata ggccttagca gtaacgggta gcagcagatg tagtttcaga cttggagtaa     5220

aactgtataa acaaaagaat cttccatatt tatacagcag agaagctgta ggactgtttg     5280

tgactggccc tgtcctggca tcagtagcat ctgtaacagc attaactgtc ttaaagagag     5340

agagagagaa ttccgaattg gggaacacac gatacctgtt tttcttttcc gttgctggca     5400

gtactgttgc gccgcagttt ggagtcactg tagttaagtg tggatgcatg tgcgtcaccg     5460

tccactcctc ctactgtatt ttattggaca ggtcagactc gccgggggcc cggcgagggt     5520

atgtcagtgt cactggatgt caaacagtaa taaattaaac caacaacaaa acgcacagcc     5580

aaaaaaaaa                                                             5589


<210>  2
<211>  1647
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1385                 1390                 1395             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1400                 1405                 1410             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1415                 1420                 1425             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1430                 1435                 1440             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1445                 1450                 1455             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1460                 1465                 1470             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1475                 1480                 1485             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1490                 1495                 1500             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1505                 1510                 1515             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1520                 1525                 1530             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1535                 1540                 1545             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1550                 1555                 1560             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1580                 1585                 1590             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1595                 1600                 1605             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1610                 1615                 1620             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1625                 1630                 1635             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1640                 1645         


<210>  3
<211>  5892
<212>  RNA
<213>  Homo sapiens

<400>  3
gcgtcttccg gcgcccgcgg aggaggcgag ggtgggacgc tgggcggagc ccgagtttag       60

gaagaggagg ggacggctgt catcaatgaa gtcatattca taatctagtc ctctctccct      120

ctgtttctgt actctgggtg actcagagag ggaagagatt cagccagcac actcctcgcg      180

agcaagcatt actctactga ctggcagaga caggagaggt agatgtccac gcccacagac      240

cctggtgcga tgccccaccc agggccttcg ccggggcctg ggccttcccc tgggccaatt      300

cttgggccta gtccaggacc aggaccatcc ccaggttccg tccacagcat gatggggcca      360

agtcctggac ctccaagtgt ctcccatcct atgccgacga tggggtccac agacttccca      420

caggaaggca tgcatcaaat gcataagccc atcgatggta tacatgacaa ggggattgta      480

gaagacatcc attgtggatc catgaagggc actggtatgc gaccacctca cccaggcatg      540

ggccctcccc agagtccaat ggatcaacac agccaaggtt atatgtcacc acacccatct      600

ccattaggag ccccagagca cgtctccagc cctatgtctg gaggaggccc aactccacct      660

cagatgccac caagccagcc gggggccctc atcccaggtg atccgcaggc catgagccag      720

cccaacagag gtccctcacc tttcagtcct gtccagctgc atcagcttcg agctcagatt      780

ttagcttata aaatgctggc ccgaggccag cccctccccg aaacgctgca gcttgcagtc      840

caggggaaaa ggacgttgcc tggcttgcag caacaacagc agcagcaaca gcagcagcag      900

cagcagcagc agcagcagca gcagcagcaa cagcagccgc agcagcagcc gccgcaacca      960

cagacgcagc aacaacagca gccggccctt gttaactaca acagaccatc tggcccgggg     1020

ccggagctga gcggcccgag caccccgcag aagctgccgg tgcccgcgcc cggcggccgg     1080

ccctcgcccg cgccccccgc agccgcgcag ccgcccgcgg ccgcagtgcc cgggccctca     1140

gtgccgcagc cggccccggg gcagccctcg cccgtcctcc agctgcagca gaagcagagc     1200

cgcatcagcc ccatccagaa accgcaaggc ctggaccccg tggaaattct gcaagagcgg     1260

gaatacagac ttcaggcccg catagctcat aggatacaag aactggaaaa tctgcctggc     1320

tctttgccac cagatttaag aaccaaagca accgtggaac taaaagcact tcggttactc     1380

aatttccagc gtcagctgag acaggaggtg gtggcctgca tgcgcaggga cacgaccctg     1440

gagacggctc tcaactccaa agcatacaaa cggagcaagc gccagactct gagagaagct     1500

cgcatgaccg agaagctgga gaagcagcag aagattgagc aggagaggaa acgccgtcag     1560

aaacaccagg aatacctgaa cagtattttg caacatgcaa aagattttaa ggaatatcat     1620

cggtctgtgg ccggaaagat ccagaagctc tccaaagcag tggcaacttg gcatgccaac     1680

actgaaagag agcagaagaa ggagacagag cggattgaaa aggagagaat gcggcgactg     1740

atggctgaag atgaggaggg ttatagaaaa ctgattgatc aaaagaaaga caggcgttta     1800

gcttaccttt tgcagcagac cgatgagtat gtagccaatc tgaccaatct ggtttgggag     1860

cacaagcaag cccaggcagc caaagagaag aagaagagga ggaggaggaa gaagaaggct     1920

gaggagaatg cagagggtgg ggagtctgcc ctgggaccgg atggagagcc catagatgag     1980

agcagccaga tgagtgacct ccctgtcaaa gtgactcaca cagaaaccgg caaggttctg     2040

ttcggaccag aagcacccaa agcaagtcag ctggacgcct ggctggaaat gaatcctggt     2100

tatgaagttg cccctagatc tgacagtgaa gagagtgatt ctgattatga ggaagaggat     2160

gaggaagaag agtccagtag gcaggaaacc gaagagaaaa tactcctgga tccaaatagc     2220

gaagaagttt ctgagaagga tgctaagcag atcattgaga cagctaagca agacgtggat     2280

gatgaataca gcatgcagta cagtgccagg ggctcccagt cctactacac cgtggctcat     2340

gccatctcgg agagggtgga gaaacagtct gccctcctaa ttaatgggac cctaaagcat     2400

taccagctcc agggcctgga atggatggtt tccctgtata ataacaactt gaacggaatc     2460

ttagccgatg aaatggggct tggaaagacc atacagacca ttgcactcat cacttatctg     2520

atggagcaca aaagactcaa tggcccctat ctcatcattg ttcccctttc gactctatct     2580

aactggacat atgaatttga caaatgggct ccttctgtgg tgaagatttc ttacaagggt     2640

actcctgcca tgcgtcgctc ccttgtcccc cagctacgga gtggcaaatt caatgtcctc     2700

ttgactactt atgagtatat tataaaagac aagcacattc ttgcaaagat tcggtggaaa     2760

tacatgatag tggacgaagg ccaccgaatg aagaatcacc actgcaagct gactcaggtc     2820

ttgaacactc actatgtggc ccccagaagg atcctcttga ctgggacccc gctgcagaat     2880

aagctccctg aactctgggc cctcctcaac ttcctcctcc caacaatttt taagagctgc     2940

agcacatttg aacaatggtt caatgctcca tttgccatga ctggtgaaag ggtggactta     3000

aatgaagaag aaactatatt gatcatcagg cgtctacata aggtgttaag accattttta     3060

ctaaggagac tgaagaaaga agttgaatcc cagcttcccg aaaaagtgga atatgtgatc     3120

aagtgtgaca tgtcagctct gcagaagatt ctgtatcgcc atatgcaagc caaggggatc     3180

cttctcacag atggttctga gaaagataag aaggggaaag gaggtgctaa gacacttatg     3240

aacactatta tgcagttgag aaaaatctgc aaccacccat atatgtttca gcacattgag     3300

gaatcctttg ctgaacacct aggctattca aatggggtca tcaatggggc tgaactgtat     3360

cgggcctcag ggaagtttga gctgcttgat cgtattctgc caaaattgag agcgactaat     3420

caccgagtgc tgcttttctg ccagatgaca tctctcatga ccatcatgga ggattatttt     3480

gcttttcgga acttccttta cctacgcctt gatggcacca ccaagtctga agatcgtgct     3540

gctttgctga agaaattcaa tgaacctgga tcccagtatt tcattttctt gctgagcaca     3600

agagctggtg gcctgggctt aaatcttcag gcagctgata cagtggtcat ctttgacagc     3660

gactggaatc ctcatcagga tctgcaggcc caagaccgag ctcaccgcat cgggcagcag     3720

aacgaggtcc gggtactgag gctctgtacc gtgaacagcg tggaggaaaa gatcctcgcg     3780

gccgcaaaat acaagctgaa cgtggatcag aaagtgatcc aggcgggcat gtttgaccaa     3840

aagtcttcaa gccacgagcg gagggcattc ctgcaggcca tcttggagca tgaggaggaa     3900

aatgaggaag aagatgaagt accggacgat gagactctga accaaatgat tgctcgacga     3960

gaagaagaat ttgacctttt tatgcggatg gacatggacc ggcggaggga agatgcccgg     4020

aacccgaaac ggaagccccg tttaatggag gaggatgagc tgccctcctg gatcattaag     4080

gatgacgctg aagtagaaag gctcacctgt gaagaagagg aggagaaaat atttgggagg     4140

gggtcccgcc agcgccgtga cgtggactac agtgacgccc tcacggagaa gcagtggcta     4200

agggccatcg aagacggcaa tttggaggaa atggaagagg aagtacggct taagaagcga     4260

aaaagacgaa gaaatgtgga taaagatcct gcaaaagaag atgtggaaaa agctaagaag     4320

agaagaggcc gccctcccgc tgagaaactg tcaccaaatc cccccaaact gacaaagcag     4380

atgaacgcta tcatcgatac tgtgataaac tacaaagata ggtgtaacgt ggagaaggtg     4440

cccagtaatt ctcagttgga aatagaagga aacagttcag ggcgacagct cagtgaagtc     4500

ttcattcagt taccttcaag gaaagaatta ccagaatact atgaattaat taggaagcca     4560

gtggatttca aaaaaataaa ggaaaggatt cgtaatcata agtaccggag cctaggcgac     4620

ctggagaagg atgtcatgct tctctgtcac aacgctcaga cgttcaacct ggagggatcc     4680

cagatctatg aagactccat cgtcttacag tcagtgttta agagtgcccg gcagaaaatt     4740

gccaaagagg aagagagtga ggatgaaagc aatgaagagg aggaagagga agatgaagaa     4800

gagtcagagt ccgaggcaaa atcagtcaag gtgaaaatta agctcaataa aaaagatgac     4860

aaaggccggg acaaagggaa aggcaagaaa aggccaaatc gaggaaaagc caaacctgta     4920

gtgagcgatt ttgacagcga tgaggagcag gatgaacgtg aacagtcaga aggaagtggg     4980

acggatgatg agtgatcagt atggaccttt ttccttggta gaactgaatt ccttcctccc     5040

ctgtctcatt tctacccagt gagttcattt gtcatatagg cactgggttg tttctatatc     5100

atcatcgtct ataaactagc tttaggatag tgccagacaa acatatgata tcatggtgta     5160

aaaaacacac acatacacaa atatttgtaa catattgtga ccaaatgggc ctcaaagatt     5220

cagattgaaa caaacaaaaa gcttttgatg gaaaatatgt gggtggatag tatatttcta     5280

tgggtgggtc taatttggta acggtttgat tgtgcctggt tttatcacct gttcagatga     5340

gaagattttt gtcttttgta gcactgataa ccaggagaag ccattaaaag ccactggtta     5400

ttttattttt catcaggcaa ttttcgaggt ttttatttgt tcggtattgt ttttttacac     5460

tgtggtacat ataagcaact ttaataggtg ataaatgtac agtagttaga tttcacctgc     5520

atatacattt ttccatttta tgctctatga tctgaacaaa agctttttga attgtataag     5580

atttatgtct actgtaaaca ttgcttaatt tttttgctct tgatttaaaa aaaagttttg     5640

ttgaaagcgc tattgaatat tgcaatctat atagtgtatt ggatggcttc ttttgtcacc     5700

ctgatctcct atgttaccaa tgtgtatcgt ctccttctcc ctaaagtgta cttaatcttt     5760

gctttctttg cacaatgtct ttggttgcaa gtcataagcc tgaggcaaat aaaattccag     5820

taatttcgaa gaatgtggtg ttggtgcttt cctaataaag aaataattta gcttgacaaa     5880

aaaaaaaaaa aa                                                         5892


<210>  4
<211>  1590
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ser Thr Pro Thr Asp Pro Gly Ala Met Pro His Pro Gly Pro Ser 
1               5                   10                  15      


Pro Gly Pro Gly Pro Ser Pro Gly Pro Ile Leu Gly Pro Ser Pro Gly 
            20                  25                  30          


Pro Gly Pro Ser Pro Gly Ser Val His Ser Met Met Gly Pro Ser Pro 
        35                  40                  45              


Gly Pro Pro Ser Val Ser His Pro Met Pro Thr Met Gly Ser Thr Asp 
    50                  55                  60                  


Phe Pro Gln Glu Gly Met His Gln Met His Lys Pro Ile Asp Gly Ile 
65                  70                  75                  80  


His Asp Lys Gly Ile Val Glu Asp Ile His Cys Gly Ser Met Lys Gly 
                85                  90                  95      


Thr Gly Met Arg Pro Pro His Pro Gly Met Gly Pro Pro Gln Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Met Ser Pro His Pro Ser Pro Leu 
        115                 120                 125             


Gly Ala Pro Glu His Val Ser Ser Pro Met Ser Gly Gly Gly Pro Thr 
    130                 135                 140                 


Pro Pro Gln Met Pro Pro Ser Gln Pro Gly Ala Leu Ile Pro Gly Asp 
145                 150                 155                 160 


Pro Gln Ala Met Ser Gln Pro Asn Arg Gly Pro Ser Pro Phe Ser Pro 
                165                 170                 175     


Val Gln Leu His Gln Leu Arg Ala Gln Ile Leu Ala Tyr Lys Met Leu 
            180                 185                 190         


Ala Arg Gly Gln Pro Leu Pro Glu Thr Leu Gln Leu Ala Val Gln Gly 
        195                 200                 205             


Lys Arg Thr Leu Pro Gly Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
    210                 215                 220                 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Pro Gln 
225                 230                 235                 240 


Gln Gln Pro Pro Gln Pro Gln Thr Gln Gln Gln Gln Gln Pro Ala Leu 
                245                 250                 255     


Val Asn Tyr Asn Arg Pro Ser Gly Pro Gly Pro Glu Leu Ser Gly Pro 
            260                 265                 270         


Ser Thr Pro Gln Lys Leu Pro Val Pro Ala Pro Gly Gly Arg Pro Ser 
        275                 280                 285             


Pro Ala Pro Pro Ala Ala Ala Gln Pro Pro Ala Ala Ala Val Pro Gly 
    290                 295                 300                 


Pro Ser Val Pro Gln Pro Ala Pro Gly Gln Pro Ser Pro Val Leu Gln 
305                 310                 315                 320 


Leu Gln Gln Lys Gln Ser Arg Ile Ser Pro Ile Gln Lys Pro Gln Gly 
                325                 330                 335     


Leu Asp Pro Val Glu Ile Leu Gln Glu Arg Glu Tyr Arg Leu Gln Ala 
            340                 345                 350         


Arg Ile Ala His Arg Ile Gln Glu Leu Glu Asn Leu Pro Gly Ser Leu 
        355                 360                 365             


Pro Pro Asp Leu Arg Thr Lys Ala Thr Val Glu Leu Lys Ala Leu Arg 
    370                 375                 380                 


Leu Leu Asn Phe Gln Arg Gln Leu Arg Gln Glu Val Val Ala Cys Met 
385                 390                 395                 400 


Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ser Lys Ala Tyr Lys 
                405                 410                 415     


Arg Ser Lys Arg Gln Thr Leu Arg Glu Ala Arg Met Thr Glu Lys Leu 
            420                 425                 430         


Glu Lys Gln Gln Lys Ile Glu Gln Glu Arg Lys Arg Arg Gln Lys His 
        435                 440                 445             


Gln Glu Tyr Leu Asn Ser Ile Leu Gln His Ala Lys Asp Phe Lys Glu 
    450                 455                 460                 


Tyr His Arg Ser Val Ala Gly Lys Ile Gln Lys Leu Ser Lys Ala Val 
465                 470                 475                 480 


Ala Thr Trp His Ala Asn Thr Glu Arg Glu Gln Lys Lys Glu Thr Glu 
                485                 490                 495     


Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu Glu 
            500                 505                 510         


Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Arg Arg Leu Ala Tyr 
        515                 520                 525             


Leu Leu Gln Gln Thr Asp Glu Tyr Val Ala Asn Leu Thr Asn Leu Val 
    530                 535                 540                 


Trp Glu His Lys Gln Ala Gln Ala Ala Lys Glu Lys Lys Lys Arg Arg 
545                 550                 555                 560 


Arg Arg Lys Lys Lys Ala Glu Glu Asn Ala Glu Gly Gly Glu Ser Ala 
                565                 570                 575     


Leu Gly Pro Asp Gly Glu Pro Ile Asp Glu Ser Ser Gln Met Ser Asp 
            580                 585                 590         


Leu Pro Val Lys Val Thr His Thr Glu Thr Gly Lys Val Leu Phe Gly 
        595                 600                 605             


Pro Glu Ala Pro Lys Ala Ser Gln Leu Asp Ala Trp Leu Glu Met Asn 
    610                 615                 620                 


Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp Ser Glu Glu Ser Asp Ser 
625                 630                 635                 640 


Asp Tyr Glu Glu Glu Asp Glu Glu Glu Glu Ser Ser Arg Gln Glu Thr 
                645                 650                 655     


Glu Glu Lys Ile Leu Leu Asp Pro Asn Ser Glu Glu Val Ser Glu Lys 
            660                 665                 670         


Asp Ala Lys Gln Ile Ile Glu Thr Ala Lys Gln Asp Val Asp Asp Glu 
        675                 680                 685             


Tyr Ser Met Gln Tyr Ser Ala Arg Gly Ser Gln Ser Tyr Tyr Thr Val 
    690                 695                 700                 


Ala His Ala Ile Ser Glu Arg Val Glu Lys Gln Ser Ala Leu Leu Ile 
705                 710                 715                 720 


Asn Gly Thr Leu Lys His Tyr Gln Leu Gln Gly Leu Glu Trp Met Val 
                725                 730                 735     


Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly 
            740                 745                 750         


Leu Gly Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu 
        755                 760                 765             


His Lys Arg Leu Asn Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser Thr 
    770                 775                 780                 


Leu Ser Asn Trp Thr Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val 
785                 790                 795                 800 


Lys Ile Ser Tyr Lys Gly Thr Pro Ala Met Arg Arg Ser Leu Val Pro 
                805                 810                 815     


Gln Leu Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr 
            820                 825                 830         


Ile Ile Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met 
        835                 840                 845             


Ile Val Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr 
    850                 855                 860                 


Gln Val Leu Asn Thr His Tyr Val Ala Pro Arg Arg Ile Leu Leu Thr 
865                 870                 875                 880 


Gly Thr Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn 
                885                 890                 895     


Phe Leu Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp 
            900                 905                 910         


Phe Asn Ala Pro Phe Ala Met Thr Gly Glu Arg Val Asp Leu Asn Glu 
        915                 920                 925             


Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro 
    930                 935                 940                 


Phe Leu Leu Arg Arg Leu Lys Lys Glu Val Glu Ser Gln Leu Pro Glu 
945                 950                 955                 960 


Lys Val Glu Tyr Val Ile Lys Cys Asp Met Ser Ala Leu Gln Lys Ile 
                965                 970                 975     


Leu Tyr Arg His Met Gln Ala Lys Gly Ile Leu Leu Thr Asp Gly Ser 
            980                 985                 990         


Glu Lys Asp Lys Lys Gly Lys Gly  Gly Ala Lys Thr Leu  Met Asn Thr 
        995                 1000                 1005             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1010                 1015                 1020             


His Ile  Glu Glu Ser Phe Ala  Glu His Leu Gly Tyr  Ser Asn Gly 
    1025                 1030                 1035             


Val Ile  Asn Gly Ala Glu Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1040                 1045                 1050             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Arg 
    1055                 1060                 1065             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1070                 1075                 1080             


Asp Tyr  Phe Ala Phe Arg Asn  Phe Leu Tyr Leu Arg  Leu Asp Gly 
    1085                 1090                 1095             


Thr Thr  Lys Ser Glu Asp Arg  Ala Ala Leu Leu Lys  Lys Phe Asn 
    1100                 1105                 1110             


Glu Pro  Gly Ser Gln Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1115                 1120                 1125             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ala Ala Asp Thr  Val Val Ile 
    1130                 1135                 1140             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1145                 1150                 1155             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1160                 1165                 1170             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1175                 1180                 1185             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1190                 1195                 1200             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1205                 1210                 1215             


Ala Ile  Leu Glu His Glu Glu  Glu Asn Glu Glu Glu  Asp Glu Val 
    1220                 1225                 1230             


Pro Asp  Asp Glu Thr Leu Asn  Gln Met Ile Ala Arg  Arg Glu Glu 
    1235                 1240                 1245             


Glu Phe  Asp Leu Phe Met Arg  Met Asp Met Asp Arg  Arg Arg Glu 
    1250                 1255                 1260             


Asp Ala  Arg Asn Pro Lys Arg  Lys Pro Arg Leu Met  Glu Glu Asp 
    1265                 1270                 1275             


Glu Leu  Pro Ser Trp Ile Ile  Lys Asp Asp Ala Glu  Val Glu Arg 
    1280                 1285                 1290             


Leu Thr  Cys Glu Glu Glu Glu  Glu Lys Ile Phe Gly  Arg Gly Ser 
    1295                 1300                 1305             


Arg Gln  Arg Arg Asp Val Asp  Tyr Ser Asp Ala Leu  Thr Glu Lys 
    1310                 1315                 1320             


Gln Trp  Leu Arg Ala Ile Glu  Asp Gly Asn Leu Glu  Glu Met Glu 
    1325                 1330                 1335             


Glu Glu  Val Arg Leu Lys Lys  Arg Lys Arg Arg Arg  Asn Val Asp 
    1340                 1345                 1350             


Lys Asp  Pro Ala Lys Glu Asp  Val Glu Lys Ala Lys  Lys Arg Arg 
    1355                 1360                 1365             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Lys Leu 
    1370                 1375                 1380             


Thr Lys  Gln Met Asn Ala Ile  Ile Asp Thr Val Ile  Asn Tyr Lys 
    1385                 1390                 1395             


Asp Arg  Cys Asn Val Glu Lys  Val Pro Ser Asn Ser  Gln Leu Glu 
    1400                 1405                 1410             


Ile Glu  Gly Asn Ser Ser Gly  Arg Gln Leu Ser Glu  Val Phe Ile 
    1415                 1420                 1425             


Gln Leu  Pro Ser Arg Lys Glu  Leu Pro Glu Tyr Tyr  Glu Leu Ile 
    1430                 1435                 1440             


Arg Lys  Pro Val Asp Phe Lys  Lys Ile Lys Glu Arg  Ile Arg Asn 
    1445                 1450                 1455             


His Lys  Tyr Arg Ser Leu Gly  Asp Leu Glu Lys Asp  Val Met Leu 
    1460                 1465                 1470             


Leu Cys  His Asn Ala Gln Thr  Phe Asn Leu Glu Gly  Ser Gln Ile 
    1475                 1480                 1485             


Tyr Glu  Asp Ser Ile Val Leu  Gln Ser Val Phe Lys  Ser Ala Arg 
    1490                 1495                 1500             


Gln Lys  Ile Ala Lys Glu Glu  Glu Ser Glu Asp Glu  Ser Asn Glu 
    1505                 1510                 1515             


Glu Glu  Glu Glu Glu Asp Glu  Glu Glu Ser Glu Ser  Glu Ala Lys 
    1520                 1525                 1530             


Ser Val  Lys Val Lys Ile Lys  Leu Asn Lys Lys Asp  Asp Lys Gly 
    1535                 1540                 1545             


Arg Asp  Lys Gly Lys Gly Lys  Lys Arg Pro Asn Arg  Gly Lys Ala 
    1550                 1555                 1560             


Lys Pro  Val Val Ser Asp Phe  Asp Ser Asp Glu Glu  Gln Asp Glu 
    1565                 1570                 1575             


Arg Glu  Gln Ser Glu Gly Ser  Gly Thr Asp Asp Glu  
    1580                 1585                 1590 


