                         SEQUENCE LISTING

<110>  King's College London
       Leucid Bio Ltd
 
<120>  Chimeric NKG2D Protein

<130>  P3882PC00

<150>  GB2007655.0
<151>  2020-05-22

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  232
<212>  PRT
<213>  Mus musculus

<400>  1

Met Ala Leu Ile Arg Asp Arg Lys Ser His His Ser Glu Met Ser Lys 
1               5                   10                  15      


Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr Ser Gln Glu 
            20                  25                  30          


Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro Gly Glu Asn 
        35                  40                  45              


Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu Lys Ile Ser Pro 
    50                  55                  60                  


Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile Arg Phe Thr 
65                  70                  75                  80  


Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr Phe Gln Pro 
                85                  90                  95      


Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys 
            100                 105                 110         


Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln 
        115                 120                 125             


Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu 
    130                 135                 140                 


Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile 
                165                 170                 175     


Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr 
            180                 185                 190         


Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr 
        195                 200                 205             


Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr 
    210                 215                 220                 


Tyr Ile Cys Met Lys Arg Ala Val 
225                 230         


<210>  2
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  2

Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile Arg Phe Thr Leu Asn 
1               5                   10                  15      


Thr Leu Met Trp Leu Ala Ile 
            20              


<210>  3
<211>  37
<212>  PRT
<213>  Mus musculus

<400>  3

Lys Ile Ser Pro Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala 
1               5                   10                  15      


Ile Arg Phe Thr Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu 
            20                  25                  30          


Thr Phe Gln Pro Val 
        35          


<210>  4
<211>  215
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu His Gln Lys Gln Arg Ser Ala Leu Pro Thr Ser Arg Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Arg Arg Ser Ser Ile Glu Glu Leu Lys 
        35                  40                  45              


Ile Ser Pro Leu Phe Val Val Arg Val Leu Val Ala Ala Met Thr Ile 
    50                  55                  60                  


Arg Phe Thr Val Ile Thr Leu Thr Trp Leu Ala Val Phe Ile Thr Leu 
65                  70                  75                  80  


Leu Cys Asn Lys Glu Val Ser Val Ser Ser Arg Glu Gly Tyr Cys Gly 
                85                  90                  95      


Pro Cys Pro Asn Asp Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe 
            100                 105                 110         


Phe Asn Glu Asn Lys Ala Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser 
        115                 120                 125             


Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe 
    130                 135                 140                 


Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ser Pro 
145                 150                 155                 160 


Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Pro Asn 
                165                 170                 175     


Glu Leu Thr Leu Val Lys Thr Pro Ser Gly Thr Cys Ala Val Tyr Gly 
            180                 185                 190         


Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ser Asn Pro Asn Thr Tyr 
        195                 200                 205             


Ile Cys Met Lys Arg Ala Val 
    210                 215 


<210>  5
<211>  23
<212>  PRT
<213>  Rattus norvegicus

<400>  5

Leu Phe Val Val Arg Val Leu Val Ala Ala Met Thr Ile Arg Phe Thr 
1               5                   10                  15      


Val Ile Thr Leu Thr Trp Leu 
            20              


<210>  6
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly 
    50                  55                  60                  


Ile Arg Phe Ile Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn 
65                  70                  75                  80  


Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
                85                  90                  95      


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
            100                 105                 110         


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
        115                 120                 125             


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
    130                 135                 140                 


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
145                 150                 155                 160 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
                165                 170                 175     


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
            180                 185                 190         


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
        195                 200                 205             


Tyr Ile Cys Met Gln Arg Thr Val 
    210                 215     


<210>  7
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  7

Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly 
1               5                   10                  15      


Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe 
            20                  25                  30          


Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser 
        35                  40                  45              


Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu 
    50                  55                  60                  


Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro 
65                  70                  75                  80  


Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn 
                85                  90                  95      


Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala 
            100                 105                 110         


Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr 
        115                 120                 125             


Ile Cys Met Gln Arg Thr Val 
    130                 135 


<210>  8
<211>  144
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Trp Ser Ala Val Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln 
1               5                   10                  15      


Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile 
            20                  25                  30          


Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp 
        35                  40                  45              


Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys 
    50                  55                  60                  


Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr 
65                  70                  75                  80  


His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp 
                85                  90                  95      


Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met 
            100                 105                 110         


Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile 
        115                 120                 125             


Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    130                 135                 140                 


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Ile Trp Ser Ala Val Phe Leu Asn Ser 
1               5                   


<210>  10
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  10

Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys 
1               5                   10                  15      


Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr 
            20                  25                  30          


Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val 
        35                  40                  45              


Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His 
    50                  55                  60                  


Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu 
65                  70                  75                  80  


Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln 
                85                  90                  95      


Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu 
            100                 105                 110         


Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
        115                 120                 125         


<210>  11
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala Ser 
    50      


<210>  12
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Gly Trp Ile Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser 
1               5                   10                  15      


Glu Phe His Asn Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr 
            20                  25                  30          


Arg Trp Gln Lys Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu 
        35                  40                  45              


Asn Ala 
    50  


<210>  13
<211>  53
<212>  PRT
<213>  Mus musculus

<400>  13

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu Lys 
        35                  40                  45              


Ile Ser Pro Met Phe 
    50              


<210>  14
<211>  47
<212>  PRT
<213>  Mus musculus

<400>  14

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu 
        35                  40                  45          


<210>  15
<211>  51
<212>  PRT
<213>  Rattus norvegicus

<400>  15

Met Ser Lys Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr 
1               5                   10                  15      


Ser Gln Glu His Gln Lys Gln Arg Ser Ala Leu Pro Thr Ser Arg Pro 
            20                  25                  30          


Gly Glu Asn Gly Ile Ile Arg Arg Arg Ser Ser Ile Glu Glu Leu Lys 
        35                  40                  45              


Ile Ser Pro 
    50      


<210>  16
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp 
            20                  25                  30          


Cys Ser Cys Ser Thr Val Ser Pro Gly Val Leu Ala Gly Ile Val Met 
        35                  40                  45              


Gly Asp Leu Val Leu Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu 
    50                  55                  60                  


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
65                  70                  75                  80  


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
                85                  90                  95      


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
            100                 105                 110         


Lys 
    


<210>  17
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  17

Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
1               5                   10                  15      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            20                  25                  30          


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        35                  40                  45              


Pro Tyr Tyr Lys 
    50          


<210>  18
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210>  19
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  19

Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr 
1               5                   10                  15      


Val Ser Pro Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu 
            20                  25                  30          


Thr Val Leu Ile Ala Leu Ala Val 
        35                  40  


<210>  20
<211>  92
<212>  PRT
<213>  Homo sapiens

<400>  20

Leu Arg Pro Val Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr 
1               5                   10                  15      


Val Ser Pro Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu 
            20                  25                  30          


Thr Val Leu Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro 
        35                  40                  45              


Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr 
    50                  55                  60                  


Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val 
65                  70                  75                  80  


Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
                85                  90          


<210>  21
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  21

Met Gly Ala Leu Glu Pro Ser Trp Cys Leu Leu Phe Leu Pro Val Leu 
1               5                   10                  15      


Leu Thr Val Gly Gly Leu Ser Pro Val Gln Ala Gln Ser Asp Thr Phe 
            20                  25                  30          


Pro Arg Cys Asp Cys Ser Ser Val Ser Pro Gly Val Leu Ala Gly Ile 
        35                  40                  45              


Val Leu Gly Asp Leu Val Leu Thr Leu Leu Ile Ala Leu Ala Val Tyr 
    50                  55                  60                  


Ser Leu Gly Arg Leu Val Ser Arg Gly Gln Gly Thr Ala Glu Gly Thr 
65                  70                  75                  80  


Arg Lys Gln His Ile Ala Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln 
                85                  90                  95      


Gly Gln Arg Pro Glu Val Tyr Ser Asp Leu Asn Thr Gln Arg Gln Tyr 
            100                 105                 110         


Tyr Arg 
        


<210>  22
<211>  51
<212>  PRT
<213>  Mus musculus

<400>  22

Tyr Ser Leu Gly Arg Leu Val Ser Arg Gly Gln Gly Thr Ala Glu Gly 
1               5                   10                  15      


Thr Arg Lys Gln His Ile Ala Glu Thr Glu Ser Pro Tyr Gln Glu Leu 
            20                  25                  30          


Gln Gly Gln Arg Pro Glu Val Tyr Ser Asp Leu Asn Thr Gln Arg Gln 
        35                  40                  45              


Tyr Tyr Arg 
    50      


<210>  23
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Val Leu Ala Gly Ile Val Leu Gly Asp Leu Val Leu Thr Leu Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val 
            20      


<210>  24
<211>  42
<212>  PRT
<213>  Mus musculus

<400>  24

Leu Ser Pro Val Gln Ala Gln Ser Asp Thr Phe Pro Arg Cys Asp Cys 
1               5                   10                  15      


Ser Ser Val Ser Pro Gly Val Leu Ala Gly Ile Val Leu Gly Asp Leu 
            20                  25                  30          


Val Leu Thr Leu Leu Ile Ala Leu Ala Val 
        35                  40          


<210>  25
<211>  93
<212>  PRT
<213>  Mus musculus

<400>  25

Leu Ser Pro Val Gln Ala Gln Ser Asp Thr Phe Pro Arg Cys Asp Cys 
1               5                   10                  15      


Ser Ser Val Ser Pro Gly Val Leu Ala Gly Ile Val Leu Gly Asp Leu 
            20                  25                  30          


Val Leu Thr Leu Leu Ile Ala Leu Ala Val Tyr Ser Leu Gly Arg Leu 
        35                  40                  45              


Val Ser Arg Gly Gln Gly Thr Ala Glu Gly Thr Arg Lys Gln His Ile 
    50                  55                  60                  


Ala Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Pro Glu 
65                  70                  75                  80  


Val Tyr Ser Asp Leu Asn Thr Gln Arg Gln Tyr Tyr Arg 
                85                  90              


<210>  26
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
                85                  90              


<210>  27
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  27

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Leu Leu 
            20                  25                  30          


Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly 
        35                  40                  45              


Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp 
    50                  55                  60                  


Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
65                  70                  75  


<210>  28
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  28

Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp Gly Lys Val 
1               5                   10                  15      


Tyr Ile Asn Met Pro Gly Arg Gly 
            20                  


<210>  29
<211>  51
<212>  PRT
<213>  Homo sapiens

<400>  29

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Leu Leu 
            20                  25                  30          


Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly 
        35                  40                  45              


Ala Val Phe 
    50      


<210>  30
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys 
65                  70      


<210>  31
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Leu Leu 
            20                  25                  30          


Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly 
        35                  40                  45              


Ala Val Phe Leu Cys 
    50              


<210>  32
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  32

Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
            20                  25                  30          


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
        35                  40                  45  


<210>  33
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
1               5                   10                  15      


Val Gly Ala Val Phe 
            20      


<210>  34
<211>  79
<212>  PRT
<213>  Mus musculus

<400>  34

Met Asp Pro Pro Gly Tyr Leu Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ser Gln Thr Ser Ala Gly Ser Cys Ser Gly Cys Gly Thr Leu Ser 
            20                  25                  30          


Leu Pro Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Met Ser Leu 
        35                  40                  45              


Leu Ile Val Gly Val Val Phe Val Cys Met Arg Pro His Gly Arg Pro 
    50                  55                  60                  


Ala Gln Glu Asp Gly Arg Val Tyr Ile Asn Met Pro Gly Arg Gly 
65                  70                  75                  


<210>  35
<211>  62
<212>  PRT
<213>  Mus musculus

<400>  35

Ser Gln Thr Ser Ala Gly Ser Cys Ser Gly Cys Gly Thr Leu Ser Leu 
1               5                   10                  15      


Pro Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Met Ser Leu Leu 
            20                  25                  30          


Ile Val Gly Val Val Phe Val Cys Met Arg Pro His Gly Arg Pro Ala 
        35                  40                  45              


Gln Glu Asp Gly Arg Val Tyr Ile Asn Met Pro Gly Arg Gly 
    50                  55                  60          


<210>  36
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  36

Cys Met Arg Pro His Gly Arg Pro Ala Gln Glu Asp Gly Arg Val Tyr 
1               5                   10                  15      


Ile Asn Met Pro Gly Arg Gly 
            20              


<210>  37
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  38
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  38

Met Asp Pro Pro Gly Tyr Leu Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala 
    


<210>  39
<211>  21
<212>  PRT
<213>  Mus musculus

<400>  39

Met Gly Ala Leu Glu Pro Ser Trp Cys Leu Leu Phe Leu Pro Val Leu 
1               5                   10                  15      


Leu Thr Val Gly Gly 
            20      


<210>  40
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Gly Gly Leu Glu Pro Cys Ser Arg Leu Leu Leu Leu Pro Leu Leu 
1               5                   10                  15      


Leu Ala Val Ser Gly 
            20      


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  41

His His His His His His 
1               5       


<210>  42
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  42

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  43
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  43

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  44
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  44

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  45

Ile Pro Asn Pro Leu Leu Gly Leu Asp 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Tag

<400>  46

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  47
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
1               5                   10                  15      


Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
            20                  25                  30          


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
        35                  40                  45              


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
    50                  55                  60                  


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys 
65                  70              


<210>  48
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  48

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  49
<211>  48
<212>  PRT
<213>  Homo sapiens

<400>  49

Gln Arg Arg Lys Tyr Arg Ser Asn Lys Gly Glu Ser Pro Val Glu Pro 
1               5                   10                  15      


Ala Glu Pro Cys His Tyr Ser Cys Pro Arg Glu Glu Glu Gly Ser Thr 
            20                  25                  30          


Ile Pro Ile Gln Glu Asp Tyr Arg Lys Pro Glu Pro Ala Cys Ser Pro 
        35                  40                  45              


<210>  50
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  50

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10          


<210>  51
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  51

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  52

Ser Gly Ser Gly 
1               


<210>  53
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  53

Gly Ser Gly Gly Gly 
1               5   


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  54

Gly Ser Gly Gly 
1               


<210>  55
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  55

Gly Pro Pro Gly Ser 
1               5   


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  56

Arg Arg Lys Arg 
1               


<210>  57
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  57

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  58
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  58

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  59
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  59

Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro 
            20              


<210>  60
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  60

Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  61
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  61

Arg Arg Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
1               5                   10                  15      


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25          


<210>  62
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  62

Arg Arg Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr 
1               5                   10                  15      


Cys Gly Asp Val Glu Glu Asn Pro Gly Pro 
            20                  25      


<210>  63
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  63

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  64
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  64

Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp Val Glu Ser 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210>  65
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  65

Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp 
1               5                   10                  15      


Val Glu Glu Asn Pro Gly Pro Met 
            20                  


<210>  66
<211>  345
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  66

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Leu Arg Pro 
            20                  25                  30          


Val Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr Val Ser Pro 
        35                  40                  45              


Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
    50                  55                  60                  


Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
65                  70                  75                  80  


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
                85                  90                  95      


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
            100                 105                 110         


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys Arg Arg Lys Arg Ser Gly Ser 
        115                 120                 125             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    130                 135                 140                 


Asn Pro Gly Pro Met Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
145                 150                 155                 160 


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Lys Ile Ser 
                165                 170                 175     


Pro Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile Arg Phe 
            180                 185                 190         


Thr Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr Phe Gln 
        195                 200                 205             


Pro Val Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
    210                 215                 220                 


Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr 
225                 230                 235                 240 


Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys 
                245                 250                 255     


Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln 
            260                 265                 270         


Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His 
        275                 280                 285             


Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser 
    290                 295                 300                 


Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu 
305                 310                 315                 320 


Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn 
                325                 330                 335     


Thr Tyr Ile Cys Met Gln Arg Thr Val 
            340                 345 


<210>  67
<211>  316
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  67

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Leu Arg Pro 
            20                  25                  30          


Val Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr Val Ser Pro 
        35                  40                  45              


Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
    50                  55                  60                  


Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
65                  70                  75                  80  


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
                85                  90                  95      


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
            100                 105                 110         


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys Arg Arg Lys Arg Ser Gly Ser 
        115                 120                 125             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    130                 135                 140                 


Asn Pro Gly Pro Met Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile 
145                 150                 155                 160 


Arg Phe Thr Leu Asn Thr Leu Met Trp Leu Ala Ile Ile Trp Ser Ala 
                165                 170                 175     


Val Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr 
            180                 185                 190         


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        195                 200                 205             


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    210                 215                 220                 


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
225                 230                 235                 240 


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                245                 250                 255     


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            260                 265                 270         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        275                 280                 285             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    290                 295                 300                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
305                 310                 315     


<210>  68
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  68

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Leu Arg Pro 
            20                  25                  30          


Val Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr Val Ser Pro 
        35                  40                  45              


Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
    50                  55                  60                  


Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
65                  70                  75                  80  


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
                85                  90                  95      


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
            100                 105                 110         


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys Arg Arg Lys Arg Ser Gly Ser 
        115                 120                 125             


Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu 
    130                 135                 140                 


Asn Pro Gly Pro Met Lys Ile Ser Pro Met Phe Val Val Arg Val Leu 
145                 150                 155                 160 


Ala Ile Ala Leu Ala Ile Arg Phe Thr Leu Asn Thr Leu Met Trp Leu 
                165                 170                 175     


Ala Ile Phe Lys Glu Thr Phe Gln Pro Val Leu Phe Asn Gln Glu Val 
            180                 185                 190         


Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp 
        195                 200                 205             


Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn 
    210                 215                 220                 


Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu 
225                 230                 235                 240 


Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser 
                245                 250                 255     


Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln 
            260                 265                 270         


Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu 
        275                 280                 285             


Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr 
    290                 295                 300                 


Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr 
305                 310                 315                 320 


Val 
    


<210>  69
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  69

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Leu Arg Pro 
            20                  25                  30          


Val Gln Ala Gln Ala Gln Ser Asp Cys Ser Cys Ser Thr Val Ser Pro 
        35                  40                  45              


Gly Val Leu Ala Gly Ile Val Met Gly Asp Leu Val Leu Thr Val Leu 
    50                  55                  60                  


Ile Ala Leu Ala Val Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg 
65                  70                  75                  80  


Gly Ala Ala Glu Ala Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu 
                85                  90                  95      


Ser Pro Tyr Gln Glu Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp 
            100                 105                 110         


Leu Asn Thr Gln Arg Pro Tyr Tyr Lys Arg Arg Lys Arg Ser Gly Ser 
        115                 120                 125             


Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
    130                 135                 140                 


Pro Gly Pro Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu 
145                 150                 155                 160 


Pro Val Ala Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro 
                165                 170                 175     


Ala Phe Tyr Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu 
            180                 185                 190         


Ser Leu Pro Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser 
        195                 200                 205             


Leu Leu Ile Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser 
    210                 215                 220                 


Pro Ala Gln Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly 
225                 230                 235                 240 


Arg Arg Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys 
                245                 250                 255     


Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Lys Ile Ser Pro 
            260                 265                 270         


Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile Arg Phe Thr 
        275                 280                 285             


Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr Phe Gln Pro 
    290                 295                 300                 


Val Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys 
305                 310                 315                 320 


Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln 
                325                 330                 335     


Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met 
            340                 345                 350         


Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp 
        355                 360                 365             


Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile 
    370                 375                 380                 


Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro 
385                 390                 395                 400 


Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr 
                405                 410                 415     


Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr 
            420                 425                 430         


Tyr Ile Cys Met Gln Arg Thr Val 
        435                 440 


<210>  70
<211>  1035
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  70
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccgattata aggacgacga cgacaagctg agacccgtgc aggcccaggc ccagagcgac      120

tgcagctgca gcaccgtgag ccccggcgtg ctggccggca tcgtgatggg cgacctggtg      180

ctgaccgtgc tcatcgccct tgccgtgtac ttcctgggca gactggtccc caggggcaga      240

ggagctgccg aggccgctac cagaaagcag aggatcaccg agacagagag cccctaccag      300

gagctgcagg gccagagatc cgacgtgtac agcgacctca acacccagag accctattac      360

aagaggcgga agcgctccgg gagtggggct accaatttct ctctcctcaa gcaagccgga      420

gacgttgagg aaaaccctgg acccatgctg tgcgccaggc ccaggcggag ccctgcccag      480

gaggacggca aggtgtacat caacatgccc ggccggggca aaatatctcc aatgttcgtt      540

gttcgagtcc ttgctatagc cttggcaatt cgattcaccc ttaacacatt gatgtggctt      600

gccattttca aagagacgtt tcagccagta ctgttcaacc aggaggtgca gatccccctg      660

accgagagct actgcggccc ctgcccaaaa aattggatct gctacaagaa caactgctac      720

cagttcttcg acgagagcaa gaactggtac gagagccagg ccagctgcat gagccagaac      780

gccagcctgc tgaaggtgta cagcaaggag gaccaggacc tgctgaagct ggtgaagagc      840

taccactgga tgggcctggt gcacatcccc accaacggca gctggcagtg ggaggacggc      900

agcatcctga gccccaacct gctgaccatc atcgagatgc agaagggcga ctgcgccctg      960

tacgccagca gcttcaaggg ctacatcgag aactgcagca cccccaacac ctacatctgc     1020

atgcagcgga ccgtg                                                      1035


<210>  71
<211>  948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  71
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccgattata aggacgacga cgacaagctg agacccgtgc aggcccaggc ccagagcgac      120

tgcagctgca gcaccgtgag ccccggcgtg ctggccggca tcgtgatggg cgacctggtg      180

ctgaccgtgc tcatcgccct tgccgtgtac ttcctgggca gactggtccc caggggcaga      240

ggagctgccg aggccgctac cagaaagcag aggatcaccg agacagagag cccctaccag      300

gagctgcagg gccagagatc cgacgtgtac agcgacctca acacccagag accctattac      360

aagaggcgga agcgctccgg gagtggggct accaatttct ctctcctcaa gcaagccgga      420

gacgttgagg aaaaccctgg acccatggtt gttcgagtcc ttgctatagc cttggcaatt      480

cgattcaccc ttaacacatt gatgtggctt gccattatct ggagcgccgt gttcctgaac      540

agcctgttca accaggaggt gcagatcccc ctgaccgaga gctactgcgg cccctgccca      600

aaaaattgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaactgg      660

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaag      720

gaggaccagg acctgctgaa gctggtgaag agctaccact ggatgggcct ggtgcacatc      780

cccaccaacg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      840

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      900

gagaactgca gcacccccaa cacctacatc tgcatgcagc ggaccgtg                   948


<210>  72
<211>  963
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  72
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccgattata aggacgacga cgacaagctg agacccgtgc aggcccaggc ccagagcgac      120

tgcagctgca gcaccgtgag ccccggcgtg ctggccggca tcgtgatggg cgacctggtg      180

ctgaccgtgc tcatcgccct tgccgtgtac ttcctgggca gactggtccc caggggcaga      240

ggagctgccg aggccgctac cagaaagcag aggatcaccg agacagagag cccctaccag      300

gagctgcagg gccagagatc cgacgtgtac agcgacctca acacccagag accctattac      360

aagaggcgga agcgctccgg gagtggggct accaatttct ctctcctcaa gcaagccgga      420

gacgttgagg aaaaccctgg acccatgaaa atatctccaa tgttcgttgt tcgagtcctt      480

gctatagcct tggcaattcg attcaccctt aacacattga tgtggcttgc cattttcaaa      540

gagacgtttc agccagtact gttcaaccag gaggtgcaga tccccctgac cgagagctac      600

tgcggcccct gcccaaaaaa ttggatctgc tacaagaaca actgctacca gttcttcgac      660

gagagcaaga actggtacga gagccaggcc agctgcatga gccagaacgc cagcctgctg      720

aaggtgtaca gcaaggagga ccaggacctg ctgaagctgg tgaagagcta ccactggatg      780

ggcctggtgc acatccccac caacggcagc tggcagtggg aggacggcag catcctgagc      840

cccaacctgc tgaccatcat cgagatgcag aagggcgact gcgccctgta cgccagcagc      900

ttcaagggct acatcgagaa ctgcagcacc cccaacacct acatctgcat gcagcggacc      960

gtg                                                                    963


<210>  73
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  73
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccgattata aggacgacga cgacaagctg agacccgtgc aggcccaggc ccagagcgac      120

tgcagctgca gcaccgtgag ccccggcgtg ctggccggca tcgtgatggg cgacctggtg      180

ctgaccgtgc tcatcgccct tgccgtgtac ttcctgggca gactggtccc caggggcaga      240

ggagctgccg aggccgctac cagaaagcag aggatcaccg agacagagag cccctaccag      300

gagctgcagg gccagagatc cgacgtgtac agcgacctca acacccagag accctattac      360

aagaggcgga agcgctccgg ctccggcgag ggccgcggca gcctgctgac ctgcggcgac      420

gtggaagaga accccggacc catgatccac ctgggccaca tcctgttcct gctgctgctg      480

cccgtggccg ctgcccaaac aacacccggc gagagatcct ccttgcccgc tttctatccc      540

ggaacatccg gaagctgttc cggatgtgga tccctttctt tgcctttgct tgctggattg      600

gtcgcagctg acgctgtcgc ttccctcctt attgtcggag ctgtcttcct gtgcgccagg      660

cccaggcgga gccctgccca ggaggacggc aaggtgtaca tcaacatgcc cggccggggc      720

aggcggaagc gctccgggag tggggctacc aatttctctc tcctcaagca agccggagac      780

gttgaggaaa accctggacc catgaaaata tctccaatgt tcgttgttcg agtccttgct      840

atagccttgg caattcgatt cacccttaac acattgatgt ggcttgccat tttcaaagag      900

acgtttcagc cagtactgtt caaccaggag gtgcagatcc ccctgaccga gagctactgc      960

ggcccctgcc caaaaaattg gatctgctac aagaacaact gctaccagtt cttcgacgag     1020

agcaagaact ggtacgagag ccaggccagc tgcatgagcc agaacgccag cctgctgaag     1080

gtgtacagca aggaggacca ggacctgctg aagctggtga agagctacca ctggatgggc     1140

ctggtgcaca tccccaccaa cggcagctgg cagtgggagg acggcagcat cctgagcccc     1200

aacctgctga ccatcatcga gatgcagaag ggcgactgcg ccctgtacgc cagcagcttc     1260

aagggctaca tcgagaactg cagcaccccc aacacctaca tctgcatgca gcggaccgtg     1320


<210>  74
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  74

Met Ile His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala 
1               5                   10                  15      


Ala Ala Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr 
            20                  25                  30          


Pro Gly Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
        35                  40                  45              


Leu Leu Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile 
    50                  55                  60                  


Val Gly Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln 
65                  70                  75                  80  


Glu Asp Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Tyr Phe Leu 
                85                  90                  95      


Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala Ala Thr Arg 
            100                 105                 110         


Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu Leu Gln Gly 
        115                 120                 125             


Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg Pro Tyr Tyr 
    130                 135                 140                 


Lys Arg Arg Lys Arg Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu 
145                 150                 155                 160 


Lys Gln Ala Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Trp Ile 
                165                 170                 175     


Arg Gly Arg Arg Ser Arg His Ser Trp Glu Met Ser Glu Phe His Asn 
            180                 185                 190         


Tyr Asn Leu Asp Leu Lys Lys Ser Asp Phe Ser Thr Arg Trp Gln Lys 
        195                 200                 205             


Gln Arg Cys Pro Val Val Lys Ser Lys Cys Arg Glu Asn Ala Ser Pro 
    210                 215                 220                 


Phe Phe Phe Cys Cys Phe Ile Ala Val Ala Met Gly Ile Arg Phe Ile 
225                 230                 235                 240 


Ile Met Val Ala Ile Trp Ser Ala Val Phe Leu Asn Ser Leu Phe Asn 
                245                 250                 255     


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
            260                 265                 270         


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
        275                 280                 285             


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
    290                 295                 300                 


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
305                 310                 315                 320 


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
                325                 330                 335     


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
            340                 345                 350         


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
        355                 360                 365             


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
    370                 375                 380                 


Gln Arg Thr Val 
385             


<210>  75
<211>  1164
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  75
atgatccacc tgggccacat cctgttcctg ctgctgctgc ccgtggccgc tgcccagacc       60

acccctggcg agcggagcag cctgcctgcc ttctaccctg gcaccagcgg cagctgcagc      120

ggctgcggca gcctgagcct gcccctgctg gccggcctgg tggccgccga cgccgtggcc      180

agcctgctga tcgtgggcgc cgtgttcctg tgcgccaggc ccaggcggag ccctgcccag      240

gaggacggca aggtgtacat caacatgccc ggccggggct acttcctggg caggctggtg      300

cccaggggca ggggcgctgc cgaggctgcc acccggaagc agcggatcac cgagaccgag      360

agcccctacc aggagctgca gggccagcgg agcgacgtgt acagcgacct gaacacccag      420

aggccctact acaagaggcg gaaaaggtct gggagtgggg ctaccaattt ctctctcctc      480

aagcaagccg gagacgttga ggaaaaccct ggacccatgg gctggatccg gggacggagg      540

agccggcaca gctgggagat gagcgagttc cacaactaca acctggacct gaagaagagc      600

gacttcagca cccggtggca gaagcagcgg tgccccgtgg tgaagagcaa gtgccgggag      660

aacgccagcc ccttcttctt ctgctgcttc atcgccgtgg ctatgggcat ccggttcatc      720

atcatggtgg ccatctggag cgccgtgttc ctgaacagcc tgttcaacca ggaggtgcag      780

atccccctga ccgagagcta ctgcggcccc tgccccaaga actggatctg ctacaagaac      840

aactgctacc agttcttcga cgagagcaag aactggtacg agagccaggc cagctgcatg      900

agccagaacg ccagcctgct gaaggtgtac agcaaggagg accaggacct gctgaagctg      960

gtgaagagct accactggat gggcctggtg cacatcccca ccaacggcag ctggcagtgg     1020

gaggacggca gcatcctgag ccccaacctg ctgaccatca tcgagatgca gaagggcgac     1080

tgcgccctgt acgccagcag cttcaagggc tacatcgaga actgcagcac ccccaacacc     1140

tacatctgca tgcagcggac cgtg                                            1164


<210>  76
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct

<400>  76

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Tyr Lys Asp Asp Asp Asp Lys Gln Thr Thr 
            20                  25                  30          


Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly Thr Ser Gly 
        35                  40                  45              


Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Leu Leu Ala Gly Leu 
    50                  55                  60                  


Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly Ala Val Phe 
65                  70                  75                  80  


Tyr Phe Leu Gly Arg Leu Val Pro Arg Gly Arg Gly Ala Ala Glu Ala 
                85                  90                  95      


Ala Thr Arg Lys Gln Arg Ile Thr Glu Thr Glu Ser Pro Tyr Gln Glu 
            100                 105                 110         


Leu Gln Gly Gln Arg Ser Asp Val Tyr Ser Asp Leu Asn Thr Gln Arg 
        115                 120                 125             


Pro Tyr Tyr Lys Arg Arg Lys Arg Ser Gly Ser Gly Glu Gly Arg Gly 
    130                 135                 140                 


Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ile 
145                 150                 155                 160 


His Leu Gly His Ile Leu Phe Leu Leu Leu Leu Pro Val Ala Ala Ala 
                165                 170                 175     


Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
            180                 185                 190         


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro Leu Leu 
        195                 200                 205             


Ala Gly Leu Val Ala Ala Asp Ala Val Ala Ser Leu Leu Ile Val Gly 
    210                 215                 220                 


Ala Val Phe Leu Cys Ala Arg Pro Arg Arg Ser Pro Ala Gln Glu Asp 
225                 230                 235                 240 


Gly Lys Val Tyr Ile Asn Met Pro Gly Arg Gly Arg Arg Lys Arg Ser 
                245                 250                 255     


Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
            260                 265                 270         


Glu Glu Asn Pro Gly Pro Met Gly Trp Ile Arg Gly Arg Arg Ser Arg 
        275                 280                 285             


His Ser Trp Glu Met Ser Glu Phe His Asn Tyr Asn Leu Asp Leu Lys 
    290                 295                 300                 


Lys Ser Asp Phe Ser Thr Arg Trp Gln Lys Gln Arg Cys Pro Val Val 
305                 310                 315                 320 


Lys Ser Lys Cys Arg Glu Asn Ala Ser Pro Phe Phe Phe Cys Cys Phe 
                325                 330                 335     


Ile Ala Val Ala Met Gly Ile Arg Phe Ile Ile Met Val Ala Ile Trp 
            340                 345                 350         


Ser Ala Val Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro 
        355                 360                 365             


Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr 
    370                 375                 380                 


Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu 
385                 390                 395                 400 


Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr 
                405                 410                 415     


Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp 
            420                 425                 430         


Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp 
        435                 440                 445             


Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys 
    450                 455                 460                 


Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn 
465                 470                 475                 480 


Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
                485                 490                 


<210>  77
<211>  1482
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  construct

<400>  77
atggctctgc ctgtgacagc tctgctgctg cctctggctc tgctgctgca cgccgctaga       60

cccgattata aggacgacga cgacaagcag accacccctg gcgagcggag cagcctgcct      120

gccttctacc ctggcaccag cggcagctgc agcggctgcg gcagcctgag cctgcccctg      180

ctggctggcc tggtggccgc cgacgccgtg gccagcctgc tgatcgtggg cgccgtgttc      240

tacttcctgg gcaggctggt gcccaggggc aggggcgctg ccgaggctgc cacccggaag      300

cagcggatca ccgagaccga gagcccctac caggagctgc agggccagcg gagcgacgtg      360

tacagcgacc tgaacaccca gaggccctac tacaagcgga gaaagcgctc cggctccggc      420

gagggccgcg gcagcctgct gacctgcggc gacgtggaag agaaccccgg acccatgatc      480

cacctgggcc acatcctgtt cctgctgctg ctgcccgtgg ccgctgccca aacaacaccc      540

ggcgagagat cctccttgcc cgctttctat cccggaacat ccggaagctg ttccggatgt      600

ggatcccttt ctttgccttt gcttgctgga ttggtcgcag ctgacgctgt cgcttccctc      660

cttattgtcg gagctgtctt cctgtgcgcc aggcccaggc ggagccctgc ccaggaggac      720

ggcaaggtgt acatcaacat gcccggccgg ggcaggcgga agcgctccgg gagtggggct      780

accaatttct ctctcctcaa gcaagccgga gacgttgagg aaaaccctgg acccatgggc      840

tggatccggg gacggaggag ccggcacagc tgggagatga gcgagttcca caactacaac      900

ctggacctga agaagagcga cttcagcacc cggtggcaga agcagcggtg ccccgtggtg      960

aagagcaagt gccgggagaa cgccagcccc ttcttcttct gctgcttcat cgccgtggct     1020

atgggcatcc ggttcatcat catggtggcc atctggagcg ccgtgttcct gaacagcctg     1080

ttcaaccagg aggtgcagat ccccctgacc gagagctact gcggcccctg ccccaagaac     1140

tggatctgct acaagaacaa ctgctaccag ttcttcgacg agagcaagaa ctggtacgag     1200

agccaggcca gctgcatgag ccagaacgcc agcctgctga aggtgtacag caaggaggac     1260

caggacctgc tgaagctggt gaagagctac cactggatgg gcctggtgca catccccacc     1320

aacggcagct ggcagtggga ggacggcagc atcctgagcc ccaacctgct gaccatcatc     1380

gagatgcaga agggcgactg cgccctgtac gccagcagct tcaagggcta catcgagaac     1440

tgcagcaccc ccaacaccta catctgcatg cagcggaccg tg                        1482


<210>  78
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  78

Gln Thr Thr Pro Gly Glu Arg Ser Ser Leu Pro Ala Phe Tyr Pro Gly 
1               5                   10                  15      


Thr Ser Gly Ser Cys Ser Gly Cys Gly Ser Leu Ser Leu Pro 
            20                  25                  30  


