               SEQUENCE LISTING

<110> Boehringer Ingelheim International GmbH

<120> VIRAL VECTORS AND NUCLEIC ACIDS FOR REGULATED GENE THERAPY

<130> P 111656

<160> 75

<170> BiSSAP 1.3.6

<210> 1
<211> 518
<212> PRT
<213> Artificial Sequence


<220> 
<223> human fusion protein (single chain human IL12 - without SP, long
      linker)

<400> 1
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          
Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  
Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      
Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             
Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 
Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 
Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     
Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         
Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             
Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 
Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 
Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     
Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         
Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             
Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 
Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 
Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys 
                325                 330                 335     
Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln 
            340                 345                 350         
Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile 
        355                 360                 365             
Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys 
    370                 375                 380                 
Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu 
385                 390                 395                 400 
Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser 
                405                 410                 415     
Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met 
            420                 425                 430         
Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro 
        435                 440                 445             
Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu 
    450                 455                 460                 
Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser 
465                 470                 475                 480 
Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile 
                485                 490                 495     
Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met 
            500                 505                 510         
Ser Tyr Leu Asn Ala Ser 
        515             

<210> 2
<211> 540
<212> PRT
<213> Artificial Sequence


<220> 
<223> single chain human IL12 - with SP, long linker

<400> 2
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      
Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          
Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              
Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  
Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  
Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      
Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         
Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             
Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 
Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 
Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     
Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         
Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             
Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 
Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 
Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     
Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         
Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             
Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 
Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 
Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                325                 330                 335     
Gly Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
            340                 345                 350         
Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
        355                 360                 365             
Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
    370                 375                 380                 
Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
385                 390                 395                 400 
Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
                405                 410                 415     
Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
            420                 425                 430         
Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
        435                 440                 445             
Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
    450                 455                 460                 
Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
465                 470                 475                 480 
Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
                485                 490                 495     
Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
            500                 505                 510         
Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
        515                 520                 525             
Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535                 540 

<210> 3
<211> 306
<212> PRT
<213> Artificial Sequence


<220> 
<223> human P40 without SP (IL12b)

<400> 3
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          
Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  
Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      
Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             
Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 
Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 
Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     
Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         
Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             
Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 
Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 
Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     
Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         
Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             
Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 
Cys Ser 
305     

<210> 4
<211> 197
<212> PRT
<213> Artificial Sequence


<220> 
<223> human p35 without SP (IL12a)

<400> 4
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      
His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          
Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              
His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  
Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  
Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      
Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         
Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             
Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 
Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 
Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     
Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         
Tyr Leu Asn Ala Ser 
        195         

<210> 5
<211> 510
<212> PRT
<213> Artificial Sequence


<220> 
<223> human single chain IL12 - without SP, short linker

<400> 5
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          
Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  
Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      
Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             
Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 
Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 
Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     
Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         
Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             
Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 
Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 
Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     
Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         
Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             
Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 
Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr 
305                 310                 315                 320 
Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu 
                325                 330                 335     
Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe 
            340                 345                 350         
Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp 
        355                 360                 365             
Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn 
    370                 375                 380                 
Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser 
385                 390                 395                 400 
Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser 
                405                 410                 415     
Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met 
            420                 425                 430         
Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln 
        435                 440                 445             
Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn 
    450                 455                 460                 
Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr 
465                 470                 475                 480 
Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg 
                485                 490                 495     
Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
            500                 505                 510 

<210> 6
<211> 532
<212> PRT
<213> Artificial Sequence


<220> 
<223> human single chain IL12 - with SP, short linker

<400> 6
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      
Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          
Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              
Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  
Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  
Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      
Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         
Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             
Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 
Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 
Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     
Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         
Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             
Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 
Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 
Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     
Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         
Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             
Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 
Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 
Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Gly Gly Ser Arg 
                325                 330                 335     
Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His 
            340                 345                 350         
His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala 
        355                 360                 365             
Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His 
    370                 375                 380                 
Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro 
385                 390                 395                 400 
Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser 
                405                 410                 415     
Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met 
            420                 425                 430         
Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln 
        435                 440                 445             
Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg 
    450                 455                 460                 
Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met 
465                 470                 475                 480 
Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu 
                485                 490                 495     
Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu 
            500                 505                 510         
His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr 
        515                 520                 525             
Leu Asn Ala Ser 
    530         

<210> 7
<211> 129
<212> DNA
<213> Artificial Sequence


<220> 
<223> SV40 poly(A)

<400> 7
cttgtttatt gcagcttata atggttacaa ataaagcaat agcatcacaa atttcacaaa     60

taaagcattt ttttcactgc attctagttg tggtttgtcc aaactcatca atgtatctta    120

acgcggccg                                                            129


<210> 8
<211> 141
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV2 ITR

<400> 8
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca    120

actccatcac taggggttcc t                                              141


<210> 9
<211> 110
<212> DNA
<213> Artificial Sequence


<220> 
<223> K19 riboswitch DNA (described in Beilstein et al., 2014)

<400> 9
ggcgcgtcct ggattcgtgg taaaacatac cagatttcga tctggagagg tgaagaatac     60

gaccacctac tacatccagc tgatgagtcc caaataggac gaaacgcgct               110


<210> 10
<211> 110
<212> RNA
<213> Artificial Sequence


<220> 
<223> K19 riboswitch RNA

<400> 10
ggcgcguccu ggauucgugg uaaaacauac cagauuucga ucuggagagg ugaagaauac     60

gaccaccuac uacauccagc ugaugagucc caaauaggac gaaacgcgcu               110


<210> 11
<211> 1623
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleotide sequence encoding functional muIL12 single chain
      (human IgG signal peptide, p40 subunit, (Gly4Ser)3 linker, p35
      subunit

<400> 11
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggtgt ccactctatg      60

tgggaactcg agaaggacgt gtacgtggtg gaagtggact ggacacctga tgctccaggc     120

gagacagtga acctgacctg tgacacaccc gaagaggacg acatcacctg gacaagcgat     180

cagagacacg gcgtgatcgg cagcggcaag accctgacaa tcaccgtgaa agagtttctg     240

gacgccggcc agtacacctg tcacaaaggc ggagagacac tgtcccacag ccatctgctg     300

ctgcacaaga aagagaacgg catctggtcc accgagatcc tgaagaactt caagaacaag     360

accttcctga agtgcgaggc ccctaactac agcggcagat tcacatgtag ctggctggtg     420

cagagaaaca tggacctgaa gttcaacatc aagtcctcca gcagcagccc cgacagcaga     480

gctgttacat gtggcatggc tagcctgagc gccgagaaag tgacactgga ccagagagac     540

tacgagaagt acagcgtgtc ctgccaagag gacgtgacct gtcctacagc cgaggaaaca     600

ctgcctatcg agctggccct ggaagccaga cagcagaaca aatacgagaa ctactctacc     660

agcttcttca tccgggacat catcaagccc gatcctccaa agaacctgca gatgaagcct     720

ctgaagaaca gccaggtcga ggtgtcctgg gagtaccctg actcttggag cacccctcac     780

agctacttca gcctgaaatt cttcgtgcgc atccagcgca agaaagaaaa gatgaaggaa     840

accgaggaag gctgcaacca gaagggcgcc ttcctggtcg aaaagacctc taccgaggtg     900

cagtgcaaag gcggcaatgt ctgtgtgcag gcccaggata ggtactacaa cagcagctgc     960

agcaagtggg cctgcgtgcc atgtagagtt agaagcggag gcggaggaag tggtggcgga    1020

ggttctggcg gcggtggaag tagagttatc cctgtgtctg gccctgccag atgcctgtct    1080

cagagcagaa acctgctgaa aaccaccgac gacatggtca agaccgccag agagaagctg    1140

aagcactaca gctgcaccgc cgaggacatc gaccacgagg atatcacaag ggaccagacc    1200

agcacactga aaacctgcct gcctctggaa ctgcataaga acgagagctg cctggccaca    1260

agagagacaa gcagcaccac aagaggcagc tgtctgcctc ctcagaaaac cagcctgatg    1320

atgacactgt gcctgggcag catctacgag gatctgaaga tgtaccagac cgagttccag    1380

gccatcaacg ccgctctgca gaaccacaac caccagcaga tcatcctgga taagggcatg    1440

ctggtggcta tcgacgagct gatgcagagc ctgaaccaca atggcgagac actgagacag    1500

aagcctccag tcggagaggc cgatccttac agagtgaaga tgaagctgtg catcctgctg    1560

cacgccttca gcaccagagt ggtcaccatc aacagagtga tgggctacct gagtagtgca    1620

tga                                                                  1623


<210> 12
<211> 521
<212> PRT
<213> Artificial Sequence


<220> 
<223> Protein sequence of functional muIL12 single chain (p40 subunit,
      (Gly4Ser)3 linker, p35 subunit) without signal peptide

<400> 12
Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          
Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 
65                  70                  75                  80  
Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 
                85                  90                  95      
Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 
            100                 105                 110         
Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 
        115                 120                 125             
Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 
    130                 135                 140                 
Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 
145                 150                 155                 160 
Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 
                165                 170                 175     
Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 
            180                 185                 190         
Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 
        195                 200                 205             
Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 
    210                 215                 220                 
Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 
225                 230                 235                 240 
His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 
                245                 250                 255     
Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 
            260                 265                 270         
Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 
        275                 280                 285             
Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 
    290                 295                 300                 
Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 
305                 310                 315                 320 
Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 
                325                 330                 335     
Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 
            340                 345                 350         
Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 
        355                 360                 365             
Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 
    370                 375                 380                 
Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 
385                 390                 395                 400 
Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 
                405                 410                 415     
Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 
            420                 425                 430         
Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 
        435                 440                 445             
Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 
    450                 455                 460                 
Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 
465                 470                 475                 480 
Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 
                485                 490                 495     
Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 
            500                 505                 510         
Arg Val Met Gly Tyr Leu Ser Ser Ala 
        515                 520     

<210> 13
<211> 57
<212> DNA
<213> Artificial Sequence


<220> 
<223> DNA coding for human IgG signal peptide

<400> 13
atgggctggt cctgcatcat tctgtttctg gtggccacag ccaccggtgt ccactct        57


<210> 14
<211> 936
<212> DNA
<213> Artificial Sequence


<220> 
<223> murine IL-12 beta chain (p40 subunit)

<400> 14
atgtgggaac tcgagaagga cgtgtacgtg gtggaagtgg actggacacc tgatgctcca      60

ggcgagacag tgaacctgac ctgtgacaca cccgaagagg acgacatcac ctggacaagc     120

gatcagagac acggcgtgat cggcagcggc aagaccctga caatcaccgt gaaagagttt     180

ctggacgccg gccagtacac ctgtcacaaa ggcggagaga cactgtccca cagccatctg     240

ctgctgcaca agaaagagaa cggcatctgg tccaccgaga tcctgaagaa cttcaagaac     300

aagaccttcc tgaagtgcga ggcccctaac tacagcggca gattcacatg tagctggctg     360

gtgcagagaa acatggacct gaagttcaac atcaagtcct ccagcagcag ccccgacagc     420

agagctgtta catgtggcat ggctagcctg agcgccgaga aagtgacact ggaccagaga     480

gactacgaga agtacagcgt gtcctgccaa gaggacgtga cctgtcctac agccgaggaa     540

acactgccta tcgagctggc cctggaagcc agacagcaga acaaatacga gaactactct     600

accagcttct tcatccggga catcatcaag cccgatcctc caaagaacct gcagatgaag     660

cctctgaaga acagccaggt cgaggtgtcc tgggagtacc ctgactcttg gagcacccct     720

cacagctact tcagcctgaa attcttcgtg cgcatccagc gcaagaaaga aaagatgaag     780

gaaaccgagg aaggctgcaa ccagaagggc gccttcctgg tcgaaaagac ctctaccgag     840

gtgcagtgca aaggcggcaa tgtctgtgtg caggcccagg ataggtacta caacagcagc     900

tgcagcaagt gggcctgcgt gccatgtaga gttaga                               936


<210> 15
<211> 582
<212> DNA
<213> Artificial Sequence


<220> 
<223> murine IL-12 alpha chain (p35 subunit)

<400> 15
agagttatcc ctgtgtctgg ccctgccaga tgcctgtctc agagcagaaa cctgctgaaa      60

accaccgacg acatggtcaa gaccgccaga gagaagctga agcactacag ctgcaccgcc     120

gaggacatcg accacgagga tatcacaagg gaccagacca gcacactgaa aacctgcctg     180

cctctggaac tgcataagaa cgagagctgc ctggccacaa gagagacaag cagcaccaca     240

agaggcagct gtctgcctcc tcagaaaacc agcctgatga tgacactgtg cctgggcagc     300

atctacgagg atctgaagat gtaccagacc gagttccagg ccatcaacgc cgctctgcag     360

aaccacaacc accagcagat catcctggat aagggcatgc tggtggctat cgacgagctg     420

atgcagagcc tgaaccacaa tggcgagaca ctgagacaga agcctccagt cggagaggcc     480

gatccttaca gagtgaagat gaagctgtgc atcctgctgc acgccttcag caccagagtg     540

gtcaccatca acagagtgat gggctacctg agtagtgcat ga                        582


<210> 16
<211> 48
<212> DNA
<213> Artificial Sequence


<220> 
<223> (Gly4Ser)3 linker

<400> 16
agcggaggcg gaggaagtgg tggcggaggt tctggcggcg gtggaagt                  48


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer -K19-riboswitch FW

<400> 17
gcgtcctgga ttcgtggtaa                                                20


<210> 18
<211> 25
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer - K19-riboswitch RV

<400> 18
gctggatgta gtaggtggtc gtatt                                          25


<210> 19
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> K19-riboswitch probe

<400> 19
atttcgatct ggagaggtg                                                 19


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer anti-FITC gene FW

<400> 20
tctgcgcgtg gaagatacag                                                20


<210> 21
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer - anti-FITC gene RV

<400> 21
caatatccgg aggagtcgta gct                                            23


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> anti-FITC gene RV

<400> 22
tgtgtattat tgcgctaggc                                                20


<210> 23
<211> 24
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer - polr2a FW

<400> 23
gccaaagact ccttcactca ctgt                                           24


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer - polr2a FW

<400> 24
ttccaagcgg caaagaatgt                                                20


<210> 25
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> polr2a probe

<400> 25
tggctctttc agcatctcgt gcagatt                                        27


<210> 26
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer - POLR2A FW

<400> 26
gcaagcggat tccatttgg                                                 19


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer - POLR2A RV

<400> 27
tctcaggccc gtagtcatcc t                                              21


<210> 28
<211> 27
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer - POLR2A probe

<400> 28
aagcaccgga ctctgcctca cttcatc                                        27


<210> 29
<211> 2714
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV.LP1-mIL-12-3â-riboswitch

<400> 29
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgttcgac cccctaaaat gggcaaacat     180

tgcaagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag     240

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg     300

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gaatgactcc     360

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc     420

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt     480

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa     540

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag     600

tgaatccgga ctctaagaga attccccgga ccggtggatc cgccaccatg ggctggtcct     660

gcatcattct gtttctggtg gccacagcca ccggtgtcca ctctatgtgg gaactcgaga     720

aggacgtgta cgtggtggaa gtggactgga cacctgatgc tccaggcgag acagtgaacc     780

tgacctgtga cacacccgaa gaggacgaca tcacctggac aagcgatcag agacacggcg     840

tgatcggcag cggcaagacc ctgacaatca ccgtgaaaga gtttctggac gccggccagt     900

acacctgtca caaaggcgga gagacactgt cccacagcca tctgctgctg cacaagaaag     960

agaacggcat ctggtccacc gagatcctga agaacttcaa gaacaagacc ttcctgaagt    1020

gcgaggcccc taactacagc ggcagattca catgtagctg gctggtgcag agaaacatgg    1080

acctgaagtt caacatcaag tcctccagca gcagccccga cagcagagct gttacatgtg    1140

gcatggctag cctgagcgcc gagaaagtga cactggacca gagagactac gagaagtaca    1200

gcgtgtcctg ccaagaggac gtgacctgtc ctacagccga ggaaacactg cctatcgagc    1260

tggccctgga agccagacag cagaacaaat acgagaacta ctctaccagc ttcttcatcc    1320

gggacatcat caagcccgat cctccaaaga acctgcagat gaagcctctg aagaacagcc    1380

aggtcgaggt gtcctgggag taccctgact cttggagcac ccctcacagc tacttcagcc    1440

tgaaattctt cgtgcgcatc cagcgcaaga aagaaaagat gaaggaaacc gaggaaggct    1500

gcaaccagaa gggcgccttc ctggtcgaaa agacctctac cgaggtgcag tgcaaaggcg    1560

gcaatgtctg tgtgcaggcc caggataggt actacaacag cagctgcagc aagtgggcct    1620

gcgtgccatg tagagttaga agcggaggcg gaggaagtgg tggcggaggt tctggcggcg    1680

gtggaagtag agttatccct gtgtctggcc ctgccagatg cctgtctcag agcagaaacc    1740

tgctgaaaac caccgacgac atggtcaaga ccgccagaga gaagctgaag cactacagct    1800

gcaccgccga ggacatcgac cacgaggata tcacaaggga ccagaccagc acactgaaaa    1860

cctgcctgcc tctggaactg cataagaacg agagctgcct ggccacaaga gagacaagca    1920

gcaccacaag aggcagctgt ctgcctcctc agaaaaccag cctgatgatg acactgtgcc    1980

tgggcagcat ctacgaggat ctgaagatgt accagaccga gttccaggcc atcaacgccg    2040

ctctgcagaa ccacaaccac cagcagatca tcctggataa gggcatgctg gtggctatcg    2100

acgagctgat gcagagcctg aaccacaatg gcgagacact gagacagaag cctccagtcg    2160

gagaggccga tccttacaga gtgaagatga agctgtgcat cctgctgcac gccttcagca    2220

ccagagtggt caccatcaac agagtgatgg gctacctgag tagtgcatga aagcttggta    2280

cccaaacaaa caaaggcgcg tcctggattc gtggtaaaac ataccagatt tcgatctgga    2340

gaggtgaaga atacgaccac ctactacatc cagctgatga gtcccaaata ggacgaaacg    2400

cgctcaaaca aacaaaagat ctcttgttta ttgcagctta taatggttac aaataaagca    2460

atagcatcac aaatttcaca aataaagcat ttttttcact gcattctagt tgtggtttgt    2520

ccaaactcat caatgtatct taacgcggcc gcacgtgcgg accgagcggc cgcaggaacc    2580

cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg    2640

accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg    2700

cagctgcctg cagg                                                      2714


<210> 30
<211> 2747
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV.LP1-aFITC-3â-riboswitch

<400> 30
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgttcgac cccctaaaat gggcaaacat     180

tgcaagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag     240

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg     300

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gaatgactcc     360

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc     420

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt     480

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa     540

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag     600

tgaatccgga ctctaagaga attccccgga ccggtggatc cgccaccatg gactggacct     660

ggcgggtgtt ctgtctgctg gctgtggctc ctggcgccca ctctcaggtg cagctggtgg     720

aatctggcgg caacctggtg cagcctggcg gctctctgag actgtcttgt gccgccagcg     780

gcttcacctt cggcagcttc agcatgagct gggtgcgaca ggctccaggc ggaggactgg     840

aatgggtggc aggcctgagc gccagaagca gcctgacaca ctacgccgac agcgtgaagg     900

gcagattcac catcagcaga gacaacgcca agaacagcgt gtacctgcag atgaacagcc     960

tgagggtgga agataccgcc gtgtactact gtgccagaag aagctacgac agcagcggct    1020

actggggcca cttctacagc tacatggacg tgtggggcca gggcaccctc gtgacagtgt    1080

ctagtggcgg aggcggaagt ggcggcggag gatcaggggg aggcggatct cagtctgtgc    1140

tgacccagcc tagcagcgtg tccgctgctc ctggccagaa agtgaccatc agctgcagcg    1200

gcagcaccag caacatcggc aacaactacg tgtcctggta tcagcagcac cccggcaagg    1260

cccccaagct gatgatctac gacgtgtcca agaggcccag cggcgtgccc gatagattca    1320

gcggctctaa gagcggcaac agcgccagcc tggacatcag cggcctgcag tctgaggacg    1380

aggccgacta ttactgcgcc gcctgggacg acagcctgtc cgagttcctg ttcggcaccg    1440

gcaccaagct gacagtgctg ggagggggag gatctggcgg gggaggctca caggtgcagc    1500

tggtggaaag cggcggaaat ctggtgcagc cagggggcag cctgagactg agctgtgccg    1560

cttccggctt tacctttggc tccttctcca tgtcctgggt gcgccaggca cctgggggcg    1620

gactggaatg ggtggccgga ctgtctgcca gaagctctct gacccactat gctgactctg    1680

tgaagggccg gttcacaatc tcccgggata acgctaagaa ctctgtgtac ctgcagatga    1740

actctctgcg cgtggaagat acagctgtgt attattgcgc taggcggagc tacgactcct    1800

ccggatattg gggacacttt tactcttata tggatgtgtg ggggcaggga acactcgtga    1860

ccgtgtcaag cggaggcggc ggaagcgggg gagggggatc tgggggcgga ggcagtcaga    1920

gtgtgctgac acagcccagc tccgtgtctg ccgccccagg acagaaagtg acaatctcct    1980

gctccggctc cacctccaat atcggaaaca attatgtgtc ttggtatcag cagcatcctg    2040

ggaaggctcc taaactgatg atctatgatg tgtctaaacg gccttccggc gtgccagaca    2100

ggttctccgg aagcaagtcc ggcaactccg cctctctgga catctccgga ctgcagagcg    2160

aggatgaggc tgactactat tgtgctgctt gggacgactc cctgagcgag tttctgtttg    2220

gaacagggac aaaactgacc gtgctgggcg gcagcggagg caagcctatc cctaatcctc    2280

tgctgggcct ggacagcacc tgaaagcttg gtacccaaac aaacaaaggc gcgtcctgga    2340

ttcgtggtaa aacataccag atttcgatct ggagaggtga agaatacgac cacctactac    2400

atccagctga tgagtcccaa ataggacgaa acgcgctcaa acaaacaaaa gatctcttgt    2460

ttattgcagc ttataatggt tacaaataaa gcaatagcat cacaaatttc acaaataaag    2520

catttttttc actgcattct agttgtggtt tgtccaaact catcaatgta tcttaacgcg    2580

gccgcacgtg cggaccgagc ggccgcagga acccctagtg atggagttgg ccactccctc    2640

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt    2700

tgcccgggcg gcctcagtga gcgagcgagc gcgcagctgc ctgcagg                  2747


<210> 31
<211> 1816
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV.CMV-cNluc-3â-riboswitch

<400> 31
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgtctagt tattaatagt aatcaattac     180

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg     240

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc     300

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac     360

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa     420

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac     480

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta     540

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga     600

cgtcaatggg agtttgtttt gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     660

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     720

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     780

agaagacacc gggaccgatc cagcctccgc ggattcgaac atcgattgaa ttccccggac     840

cggtggatcc gccaccatgg tcttcacact cgaagatttc gttggggact ggcgacagac     900

agccggctac aacctggacc aagtccttga acagggaggt gtgtccagtt tgtttcagaa     960

tctcggggtg tccgtaactc cgatccaaag gattgtcctg agcggtgaaa atgggctgaa    1020

gatcgacatc catgtcatca tcccgtatga aggtctgagc ggcgaccaaa tgggccagat    1080

cgaaaaaatt tttaaggtgg tgtaccctgt ggatgatcat cactttaagg tgatcctgca    1140

ctatggcaca ctggtaatcg acggggttac gccgaacatg atcgactatt tcggacggcc    1200

gtatgaaggc atcgccgtgt tcgacggcaa aaagatcact gtaacaggga ccctgtggaa    1260

cggcaacaaa attatcgacg agcgcctgat caaccccgac ggctccctgc tgttccgagt    1320

aaccatcaac ggagtgaccg gctggcggct gtgcgaacgc attctggcgt aaaagcttgg    1380

tacccaaaca aacaaaggcg cgtcctggat tcgtggtaaa acataccaga tttcgatctg    1440

gagaggtgaa gaatacgacc acctactaca tccagctgat gagtcccaaa taggacgaaa    1500

cgcgctcaaa caaacaaaag atctcttgtt tattgcagct tataatggtt acaaataaag    1560

caatagcatc acaaatttca caaataaagc atttttttca ctgcattcta gttgtggttt    1620

gtccaaactc atcaatgtat cttaacgcgg ccgcacgtgc ggaccgagcg gccgcaggaa    1680

cccctagtga tggagttggc cactccctct ctgcgcgctc gctcgctcac tgaggccggg    1740

cgaccaaagg tcgcccgacg cccgggcttt gcccgggcgg cctcagtgag cgagcgagcg    1800

cgcagctgcc tgcagg                                                    1816


<210> 32
<211> 2059
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV.CMV-GFP-3â-riboswitch

<400> 32
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgtctagt tattaatagt aatcaattac     180

ggggtcatta gttcatagcc catatatgga gttccgcgtt acataactta cggtaaatgg     240

cccgcctggc tgaccgccca acgacccccg cccattgacg tcaataatga cgtatgttcc     300

catagtaacg ccaataggga ctttccattg acgtcaatgg gtggagtatt tacggtaaac     360

tgcccacttg gcagtacatc aagtgtatca tatgccaagt acgcccccta ttgacgtcaa     420

tgacggtaaa tggcccgcct ggcattatgc ccagtacatg accttatggg actttcctac     480

ttggcagtac atctacgtat tagtcatcgc tattaccatg gtgatgcggt tttggcagta     540

catcaatggg cgtggatagc ggtttgactc acggggattt ccaagtctcc accccattga     600

cgtcaatggg agtttgtttt gcaccaaaat caacgggact ttccaaaatg tcgtaacaac     660

tccgccccat tgacgcaaat gggcggtagg cgtgtacggt gggaggtcta tataagcaga     720

gctcgtttag tgaaccgtca gatcgcctgg agacgccatc cacgctgttt tgacctccat     780

agaagacacc gggaccgatc cagcctccgc ggattcgaac atcgattgaa ttccccggac     840

cggtggatcc gccaccatgg tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat     900

cctggtcgag ctggacggcg acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga     960

gggcgatgcc acctacggca agctgaccct gaagttcatc tgcaccaccg gcaagctgcc    1020

cgtgccctgg cccaccctcg tgaccaccct gacctacggc gtgcagtgct tcagccgcta    1080

ccccgaccac atgaagcagc acgacttctt caagtccgcc atgcccgaag gctacgtcca    1140

ggagcgcacc atcttcttca aggacgacgg caactacaag acccgcgccg aggtgaagtt    1200

cgagggcgac accctggtga accgcatcga gctgaagggc atcgacttca aggaggacgg    1260

caacatcctg gggcacaagc tggagtacaa ctacaacagc cacaacgtct atatcatggc    1320

cgacaagcag aagaacggca tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg    1380

cagcgtgcag ctcgccgacc actaccagca gaacaccccc atcggcgacg gccccgtgct    1440

gctgcccgac aaccactacc tgagcaccca gtccgccctg agcaaagacc ccaacgagaa    1500

gcgcgatcac atggtcctgc tggagttcgt gaccgccgcc gggatcactc tcggcatgga    1560

cgagctgtac aagtccggcc ggactcagat ttcgagctca agttttgaat tttagaagct    1620

tggtacccaa acaaacaaag gcgcgtcctg gattcgtggt aaaacatacc agatttcgat    1680

ctggagaggt gaagaatacg accacctact acatccagct gatgagtccc aaataggacg    1740

aaacgcgctc aaacaaacaa aagatctctt gtttattgca gcttataatg gttacaaata    1800

aagcaatagc atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg    1860

tttgtccaaa ctcatcaatg tatcttaacg cggccgcacg tgcggaccga gcggccgcag    1920

gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc    1980

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga    2040

gcgcgcagct gcctgcagg                                                 2059


<210> 33
<211> 22
<212> PRT
<213> Homo sapiens


<220> 
<223> human IL-12 SP

<400> 33
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      
Ala Ser Pro Leu Val Ala 
            20          

<210> 34
<211> 508
<212> PRT
<213> Artificial Sequence


<220> 
<223> human single chain IL12 - without SP, G4S linker

<400> 34
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
1               5                   10                  15      
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
            20                  25                  30          
Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
        35                  40                  45              
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
    50                  55                  60                  
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
65                  70                  75                  80  
Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
                85                  90                  95      
Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
            100                 105                 110         
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
        115                 120                 125             
Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
    130                 135                 140                 
Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
145                 150                 155                 160 
Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
                165                 170                 175     
Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
            180                 185                 190         
Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
        195                 200                 205             
Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
    210                 215                 220                 
Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
225                 230                 235                 240 
Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
                245                 250                 255     
Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
            260                 265                 270         
Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
        275                 280                 285             
Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
    290                 295                 300                 
Cys Ser Gly Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp 
305                 310                 315                 320 
Pro Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala 
                325                 330                 335     
Val Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro 
            340                 345                 350         
Cys Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr 
        355                 360                 365             
Ser Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser 
    370                 375                 380                 
Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu 
385                 390                 395                 400 
Ala Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile 
                405                 410                 415     
Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala 
            420                 425                 430         
Lys Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met 
        435                 440                 445             
Leu Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu 
    450                 455                 460                 
Thr Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr 
465                 470                 475                 480 
Lys Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val 
                485                 490                 495     
Thr Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser 
            500                 505             

<210> 35
<211> 530
<212> PRT
<213> Artificial Sequence


<220> 
<223> human single chain IL12 - with SP, G4S linker

<400> 35
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      
Ala Ser Pro Leu Val Ala Ile Trp Glu Leu Lys Lys Asp Val Tyr Val 
            20                  25                  30          
Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu 
        35                  40                  45              
Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln 
    50                  55                  60                  
Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys 
65                  70                  75                  80  
Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val 
                85                  90                  95      
Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp 
            100                 105                 110         
Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe 
        115                 120                 125             
Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp 
    130                 135                 140                 
Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg 
145                 150                 155                 160 
Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser 
                165                 170                 175     
Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu 
            180                 185                 190         
Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile 
        195                 200                 205             
Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr 
    210                 215                 220                 
Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn 
225                 230                 235                 240 
Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp 
                245                 250                 255     
Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr 
            260                 265                 270         
Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg 
        275                 280                 285             
Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala 
    290                 295                 300                 
Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser 
305                 310                 315                 320 
Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Arg Asn Leu 
                325                 330                 335     
Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu His His Ser 
            340                 345                 350         
Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys Ala Arg Gln 
        355                 360                 365             
Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp His Glu Asp 
    370                 375                 380                 
Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu Pro Leu Glu 
385                 390                 395                 400 
Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr Ser Phe Ile 
                405                 410                 415     
Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe Met Met Ala 
            420                 425                 430         
Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Val Glu 
        435                 440                 445             
Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys Arg Gln Ile 
    450                 455                 460                 
Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu Met Gln Ala 
465                 470                 475                 480 
Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser Leu Glu Glu 
                485                 490                 495     
Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu Leu His Ala 
            500                 505                 510         
Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser Tyr Leu Asn 
        515                 520                 525             
Ala Ser 
    530 

<210> 36
<211> 518
<212> PRT
<213> Artificial Sequence


<220> 
<223> hIL-12 p35-p40, (G4S)3 linker

<400> 36
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      
His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          
Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              
His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  
Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  
Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      
Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         
Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             
Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 
Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 
Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     
Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         
Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             
Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu 
    210                 215                 220                 
Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys 
225                 230                 235                 240 
Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser 
                245                 250                 255     
Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe 
            260                 265                 270         
Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser 
        275                 280                 285             
His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
    290                 295                 300                 
Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg 
305                 310                 315                 320 
Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
                325                 330                 335     
Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser 
            340                 345                 350         
Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu 
        355                 360                 365             
Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln 
    370                 375                 380                 
Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val 
385                 390                 395                 400 
Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser 
                405                 410                 415     
Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
            420                 425                 430         
Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr 
        435                 440                 445             
Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys 
    450                 455                 460                 
Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe 
465                 470                 475                 480 
Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile 
                485                 490                 495     
Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp 
            500                 505                 510         
Ala Ser Val Pro Cys Ser 
        515             

<210> 37
<211> 540
<212> PRT
<213> Artificial Sequence


<220> 
<223> hIL-12 p35-p40, (G4S)3 linker with signal peptide

<400> 37
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      
Ala Ser Pro Leu Val Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          
Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              
Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  
Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  
Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      
Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         
Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             
Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 
Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 
Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     
Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         
Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             
Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys 
225                 230                 235                 240 
Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
                245                 250                 255     
Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
            260                 265                 270         
Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
        275                 280                 285             
Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
    290                 295                 300                 
Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
305                 310                 315                 320 
Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
                325                 330                 335     
Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
            340                 345                 350         
Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
        355                 360                 365             
Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
    370                 375                 380                 
Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
385                 390                 395                 400 
Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
                405                 410                 415     
Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
            420                 425                 430         
Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
        435                 440                 445             
Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
    450                 455                 460                 
Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
465                 470                 475                 480 
Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
                485                 490                 495     
Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
            500                 505                 510         
Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
        515                 520                 525             
Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser 
    530                 535                 540 

<210> 38
<211> 510
<212> PRT
<213> Artificial Sequence


<220> 
<223> hIL-12 p35-p40, G6S linker

<400> 38
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      
His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          
Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              
His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  
Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  
Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      
Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         
Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             
Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 
Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 
Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     
Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         
Tyr Leu Asn Ala Ser Gly Gly Gly Gly Gly Gly Ser Ile Trp Glu Leu 
        195                 200                 205             
Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro 
    210                 215                 220                 
Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile 
225                 230                 235                 240 
Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr 
                245                 250                 255     
Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys 
            260                 265                 270         
His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys 
        275                 280                 285             
Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu 
    290                 295                 300                 
Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly 
305                 310                 315                 320 
Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe 
                325                 330                 335     
Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys 
            340                 345                 350         
Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu 
        355                 360                 365             
Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala 
    370                 375                 380                 
Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu 
385                 390                 395                 400 
Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys 
                405                 410                 415     
Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg 
            420                 425                 430         
Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His 
        435                 440                 445             
Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys 
    450                 455                 460                 
Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val 
465                 470                 475                 480 
Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr 
                485                 490                 495     
Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser 
            500                 505                 510 

<210> 39
<211> 532
<212> PRT
<213> Artificial Sequence


<220> 
<223> hIL-12 p35-p40, G6S linker, with signal peptide

<400> 39
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      
Ala Ser Pro Leu Val Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          
Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              
Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  
Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  
Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      
Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         
Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             
Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 
Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 
Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     
Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         
Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             
Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Gly 
    210                 215                 220                 
Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp 
225                 230                 235                 240 
Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr 
                245                 250                 255     
Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val 
            260                 265                 270         
Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp 
        275                 280                 285             
Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser 
    290                 295                 300                 
Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile 
305                 310                 315                 320 
Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu 
                325                 330                 335     
Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile 
            340                 345                 350         
Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp 
        355                 360                 365             
Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val 
    370                 375                 380                 
Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp 
385                 390                 395                 400 
Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val 
                405                 410                 415     
Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe 
            420                 425                 430         
Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys 
        435                 440                 445             
Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp 
    450                 455                 460                 
Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln 
465                 470                 475                 480 
Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp 
                485                 490                 495     
Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val 
            500                 505                 510         
Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser 
        515                 520                 525             
Val Pro Cys Ser 
    530         

<210> 40
<211> 508
<212> PRT
<213> Artificial Sequence


<220> 
<223> hIL-12 p35-p40, G4S linker #

<400> 40
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      
His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          
Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              
His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  
Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  
Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      
Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         
Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             
Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 
Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 
Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     
Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         
Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys 
        195                 200                 205             
Asp Val Tyr Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu 
    210                 215                 220                 
Met Val Val Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp 
225                 230                 235                 240 
Thr Leu Asp Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr 
                245                 250                 255     
Ile Gln Val Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys 
            260                 265                 270         
Gly Gly Glu Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu 
        275                 280                 285             
Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys 
    290                 295                 300                 
Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe 
305                 310                 315                 320 
Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val 
                325                 330                 335     
Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala 
            340                 345                 350         
Ala Thr Leu Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu 
        355                 360                 365             
Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu 
    370                 375                 380                 
Ser Leu Pro Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr 
385                 390                 395                 400 
Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp 
                405                 410                 415     
Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val 
            420                 425                 430         
Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr 
        435                 440                 445             
Phe Ser Leu Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu 
    450                 455                 460                 
Lys Lys Asp Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys 
465                 470                 475                 480 
Arg Lys Asn Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser 
                485                 490                 495     
Ser Ser Trp Ser Glu Trp Ala Ser Val Pro Cys Ser 
            500                 505             

<210> 41
<211> 530
<212> PRT
<213> Artificial Sequence


<220> 
<223> hIL-12 p35-p40, G4S linker with signal peptide

<400> 41
Met Cys His Gln Gln Leu Val Ile Ser Trp Phe Ser Leu Val Phe Leu 
1               5                   10                  15      
Ala Ser Pro Leu Val Ala Arg Asn Leu Pro Val Ala Thr Pro Asp Pro 
            20                  25                  30          
Gly Met Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val 
        35                  40                  45              
Ser Asn Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys 
    50                  55                  60                  
Thr Ser Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser 
65                  70                  75                  80  
Thr Val Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys 
                85                  90                  95      
Leu Asn Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala 
            100                 105                 110         
Ser Arg Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr 
        115                 120                 125             
Glu Asp Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys 
    130                 135                 140                 
Leu Leu Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu 
145                 150                 155                 160 
Ala Val Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr 
                165                 170                 175     
Val Pro Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys 
            180                 185                 190         
Ile Lys Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr 
        195                 200                 205             
Ile Asp Arg Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser 
    210                 215                 220                 
Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu Asp Trp Tyr 
225                 230                 235                 240 
Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp Thr Pro Glu 
                245                 250                 255     
Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu Val Leu Gly 
            260                 265                 270         
Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly Asp Ala Gly 
        275                 280                 285             
Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His Ser Leu Leu 
    290                 295                 300                 
Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp Ile Leu Lys 
305                 310                 315                 320 
Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys Glu Ala Lys 
                325                 330                 335     
Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr Ile Ser Thr 
            340                 345                 350         
Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser Asp Pro Gln 
        355                 360                 365             
Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg Val Arg Gly 
    370                 375                 380                 
Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu Asp Ser Ala 
385                 390                 395                 400 
Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met Val Asp Ala 
                405                 410                 415     
Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe Phe Ile Arg 
            420                 425                 430         
Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu Lys Pro Leu 
        435                 440                 445             
Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Thr Trp 
    450                 455                 460                 
Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val Gln Val Gln 
465                 470                 475                 480 
Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr Asp Lys Thr 
                485                 490                 495     
Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser Val Arg Ala 
            500                 505                 510         
Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala Ser Val Pro 
        515                 520                 525             
Cys Ser 
    530 

<210> 42
<211> 661
<212> DNA
<213> Artificial Sequence


<220> 
<223> LP1-Promotor/SV40-intron

<400> 42
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc      60

tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac ctccaacatc     120

cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg tggtttaggt     180

agtgtgagag ggtccgggtt caaaaccact tgctgggtgg ggagtcgtca gtaagtggct     240

atgccccgac cccgaagcct gtttccccat ctgtacaatg gaaatgataa agacgcccat     300

ctgataggga atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     360

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     420

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     480

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     540

accactgacc tgggacagtg aatccggact ctaaggtaaa tataaaattt ttaagtgtat     600

aatgtgttaa actactgatt ctaattgttt ctctatttta gattccaacc tttggaactg     660

a                                                                     661


<210> 43
<211> 145
<212> DNA
<213> Artificial Sequence


<220> 
<223> WT AAV2 ITR (reverse complement of the conventional view)

<400> 43
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg    120

gccaactcca tcactagggg ttcct                                          145


<210> 44
<211> 130
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV ITR delta(C) lacks 4nt at the 3'end and 11nt in the so called
      c-region

<400> 44
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcagc    120

tgcctgcagg                                                           130


<210> 45
<211> 110
<212> DNA
<213> Artificial Sequence


<220> 
<223> K19 riboswitch-inactive DNA

<400> 45
ggcgcgtcct ggattcgtgg taaaacatac cagatttcga tctggagagg tgaagaatac     60

gaccacctac tacatccagc tgatgagtcc caaataggac gagacgcgct               110


<210> 46
<211> 2703
<212> DNA
<213> Artificial Sequence


<220> 
<223> sequence according to Seq ID 29 as confirmed by confirmatory
      sequencing having an 11nt deletion in the left ITR

<400> 46
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcgtcg ggcgaccttt      60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact     120

aggggttcct gcggccgcac gcgttcgacc ccctaaaatg ggcaaacatt gcaagcaaac     180

agcaaacaca cagccctccc tgcctgctga ccttggagct ggggcagagg tcagagacct     240

ctctgggccc atgccacctc caacatccac tcgacccctt ggaatttcgg tggagaggag     300

cagaggttgt cctggcgtgg tttaggtagt gtgagagggg aatgactcct ttcggtaagt     360

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     420

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     480

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     540

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt gaatccggac     600

tctaagagaa ttccccggac cggtggatcc gccaccatgg gctggtcctg catcattctg     660

tttctggtgg ccacagccac cggtgtccac tctatgtggg aactcgagaa ggacgtgtac     720

gtggtggaag tggactggac acctgatgct ccaggcgaga cagtgaacct gacctgtgac     780

acacccgaag aggacgacat cacctggaca agcgatcaga gacacggcgt gatcggcagc     840

ggcaagaccc tgacaatcac cgtgaaagag tttctggacg ccggccagta cacctgtcac     900

aaaggcggag agacactgtc ccacagccat ctgctgctgc acaagaaaga gaacggcatc     960

tggtccaccg agatcctgaa gaacttcaag aacaagacct tcctgaagtg cgaggcccct    1020

aactacagcg gcagattcac atgtagctgg ctggtgcaga gaaacatgga cctgaagttc    1080

aacatcaagt cctccagcag cagccccgac agcagagctg ttacatgtgg catggctagc    1140

ctgagcgccg agaaagtgac actggaccag agagactacg agaagtacag cgtgtcctgc    1200

caagaggacg tgacctgtcc tacagccgag gaaacactgc ctatcgagct ggccctggaa    1260

gccagacagc agaacaaata cgagaactac tctaccagct tcttcatccg ggacatcatc    1320

aagcccgatc ctccaaagaa cctgcagatg aagcctctga agaacagcca ggtcgaggtg    1380

tcctgggagt accctgactc ttggagcacc cctcacagct acttcagcct gaaattcttc    1440

gtgcgcatcc agcgcaagaa agaaaagatg aaggaaaccg aggaaggctg caaccagaag    1500

ggcgccttcc tggtcgaaaa gacctctacc gaggtgcagt gcaaaggcgg caatgtctgt    1560

gtgcaggccc aggataggta ctacaacagc agctgcagca agtgggcctg cgtgccatgt    1620

agagttagaa gcggaggcgg aggaagtggt ggcggaggtt ctggcggcgg tggaagtaga    1680

gttatccctg tgtctggccc tgccagatgc ctgtctcaga gcagaaacct gctgaaaacc    1740

accgacgaca tggtcaagac cgccagagag aagctgaagc actacagctg caccgccgag    1800

gacatcgacc acgaggatat cacaagggac cagaccagca cactgaaaac ctgcctgcct    1860

ctggaactgc ataagaacga gagctgcctg gccacaagag agacaagcag caccacaaga    1920

ggcagctgtc tgcctcctca gaaaaccagc ctgatgatga cactgtgcct gggcagcatc    1980

tacgaggatc tgaagatgta ccagaccgag ttccaggcca tcaacgccgc tctgcagaac    2040

cacaaccacc agcagatcat cctggataag ggcatgctgg tggctatcga cgagctgatg    2100

cagagcctga accacaatgg cgagacactg agacagaagc ctccagtcgg agaggccgat    2160

ccttacagag tgaagatgaa gctgtgcatc ctgctgcacg ccttcagcac cagagtggtc    2220

accatcaaca gagtgatggg ctacctgagt agtgcatgaa agcttggtac ccaaacaaac    2280

aaaggcgcgt cctggattcg tggtaaaaca taccagattt cgatctggag aggtgaagaa    2340

tacgaccacc tactacatcc agctgatgag tcccaaatag gacgaaacgc gctcaaacaa    2400

acaaaagatc tcttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca    2460

aatttcacaa ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc    2520

aatgtatctt aacgcggccg cacgtgcgga ccgagcggcc gcaggaaccc ctagtgatgg    2580

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg    2640

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc agctgcctgc    2700

agg                                                                  2703


<210> 47
<211> 2722
<212> DNA
<213> Artificial Sequence


<220> 
<223> Sequence accoding to Seq ID 29 with the wt AAV2 ITR sequences

<400> 47
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     120

gccaactcca tcactagggg ttcctgcggc cgcacgcgtt cgacccccta aaatgggcaa     180

acattgcaag caaacagcaa acacacagcc ctccctgcct gctgaccttg gagctggggc     240

agaggtcaga gacctctctg ggcccatgcc acctccaaca tccactcgac cccttggaat     300

ttcggtggag aggagcagag gttgtcctgg cgtggtttag gtagtgtgag aggggaatga     360

ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt     420

aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg     480

gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct     540

taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg     600

acagtgaatc cggactctaa gagaattccc cggaccggtg gatccgccac catgggctgg     660

tcctgcatca ttctgtttct ggtggccaca gccaccggtg tccactctat gtgggaactc     720

gagaaggacg tgtacgtggt ggaagtggac tggacacctg atgctccagg cgagacagtg     780

aacctgacct gtgacacacc cgaagaggac gacatcacct ggacaagcga tcagagacac     840

ggcgtgatcg gcagcggcaa gaccctgaca atcaccgtga aagagtttct ggacgccggc     900

cagtacacct gtcacaaagg cggagagaca ctgtcccaca gccatctgct gctgcacaag     960

aaagagaacg gcatctggtc caccgagatc ctgaagaact tcaagaacaa gaccttcctg    1020

aagtgcgagg cccctaacta cagcggcaga ttcacatgta gctggctggt gcagagaaac    1080

atggacctga agttcaacat caagtcctcc agcagcagcc ccgacagcag agctgttaca    1140

tgtggcatgg ctagcctgag cgccgagaaa gtgacactgg accagagaga ctacgagaag    1200

tacagcgtgt cctgccaaga ggacgtgacc tgtcctacag ccgaggaaac actgcctatc    1260

gagctggccc tggaagccag acagcagaac aaatacgaga actactctac cagcttcttc    1320

atccgggaca tcatcaagcc cgatcctcca aagaacctgc agatgaagcc tctgaagaac    1380

agccaggtcg aggtgtcctg ggagtaccct gactcttgga gcacccctca cagctacttc    1440

agcctgaaat tcttcgtgcg catccagcgc aagaaagaaa agatgaagga aaccgaggaa    1500

ggctgcaacc agaagggcgc cttcctggtc gaaaagacct ctaccgaggt gcagtgcaaa    1560

ggcggcaatg tctgtgtgca ggcccaggat aggtactaca acagcagctg cagcaagtgg    1620

gcctgcgtgc catgtagagt tagaagcgga ggcggaggaa gtggtggcgg aggttctggc    1680

ggcggtggaa gtagagttat ccctgtgtct ggccctgcca gatgcctgtc tcagagcaga    1740

aacctgctga aaaccaccga cgacatggtc aagaccgcca gagagaagct gaagcactac    1800

agctgcaccg ccgaggacat cgaccacgag gatatcacaa gggaccagac cagcacactg    1860

aaaacctgcc tgcctctgga actgcataag aacgagagct gcctggccac aagagagaca    1920

agcagcacca caagaggcag ctgtctgcct cctcagaaaa ccagcctgat gatgacactg    1980

tgcctgggca gcatctacga ggatctgaag atgtaccaga ccgagttcca ggccatcaac    2040

gccgctctgc agaaccacaa ccaccagcag atcatcctgg ataagggcat gctggtggct    2100

atcgacgagc tgatgcagag cctgaaccac aatggcgaga cactgagaca gaagcctcca    2160

gtcggagagg ccgatcctta cagagtgaag atgaagctgt gcatcctgct gcacgccttc    2220

agcaccagag tggtcaccat caacagagtg atgggctacc tgagtagtgc atgaaagctt    2280

ggtacccaaa caaacaaagg cgcgtcctgg attcgtggta aaacatacca gatttcgatc    2340

tggagaggtg aagaatacga ccacctacta catccagctg atgagtccca aataggacga    2400

aacgcgctca aacaaacaaa agatctcttg tttattgcag cttataatgg ttacaaataa    2460

agcaatagca tcacaaattt cacaaataaa gcattttttt cactgcattc tagttgtggt    2520

ttgtccaaac tcatcaatgt atcttaacgc ggccgcacgt gcggaccgag cggccgcagg    2580

aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc actgaggccg    2640

cccgggcaaa gcccgggcgt cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag    2700

cgcgcagaga gggagtggcc aa                                             2722


<210> 48
<211> 145
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV2 ITR conventional view, see Wilmot et al, see Seq ID 43 for
      its reverse complement

<400> 48
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg     60

ccgcccgggc aaagcccggg cgtcgggcga cctttggtcg cccggcctca gtgagcgagc    120

gagcgcgcag agagggagtg gccaa                                          145


<210> 49
<211> 145
<212> DNA
<213> Artificial Sequence


<220> 
<223> AAV ITR according to Stratagene (reverse complement of the
      conventional view)

<400> 49
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca    120

actccatcac taggggttcc tgcgg                                          145


<210> 50
<211> 2705
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV.LP1-hIL-12-3'-riboswitch: signalpeptide, IL12
      p40-(G4S)3-p35; carrying the 4nt deletion in the ITR, as confimed
      by sequencing

<400> 50
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgttcgac cccctaaaat gggcaaacat     180

tgcaagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag     240

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg     300

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gaatgactcc     360

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc     420

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt     480

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa     540

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag     600

tgaatccgga ctctaagaga attccccgga ccggtggatc cgccaccatg ggctggtcct     660

gcatcattct gtttctggtg gccacagcca ccggcgtgca ctctatttgg gagctgaaga     720

aagacgtgta cgtggtcgag ctggactggt atcctgatgc tcccggcgaa atggtggtgc     780

tgacctgtga tacacccgaa gaggacggca tcacatggac actggatcag tctagcgagg     840

tgctcggcag cggcaagaca ctgaccatcc aagtgaaaga gtttggcgac gccggccagt     900

acacatgtca caaaggcgga gaggtgctga gccattctct gctgctgctc cacaagaaag     960

aggatggcat ttggagcacc gacatcctga aggaccagaa agagcccaag aacaagacct    1020

tcctgagatg cgaggccaag aactacagcg gcagattcac ctgttggtgg ctgaccacca    1080

tcagcaccga tctgaccttc agcgtgaagt ccagcagagg cagctctgat cctcaaggcg    1140

ttacatgtgg cgccgctaca ctgtctgccg aaagagtgcg gggcgacaac aaagagtacg    1200

agtacagcgt cgagtgccaa gaggattctg cctgtcctgc cgccgaggaa tctctgccta    1260

tcgaagtgat ggtggacgcc gtgcacaagc tgaagtacga gaactacacc agcagctttt    1320

tcatccggga catcatcaag cccgatcctc caaagaacct gcagctgaag cccctgaaga    1380

acagcagaca ggtggaagtg tcttgggagt accccgacac atggtctacc cctcacagct    1440

acttcagcct gaccttctgt gtgcaagtgc agggcaagtc caagcgcgag aagaaagatc    1500

gggtgttcac cgacaagacc agcgccaccg tgatctgcag aaagaacgcc agcatcagcg    1560

tgcgcgctca ggataggtac tacagcagct cttggagcga gtgggcctct gttccttgtt    1620

ctggcggcgg aggaagcgga ggcggaggat ctggtggtgg tggaagtaga aacctgccag    1680

tggctacccc tgatccgggc atgtttcctt gtctgcacca cagccagaac ctgctgagag    1740

ccgtgtccaa tatgctgcag aaggcccggc agacccttga gttctaccct tgcaccagcg    1800

aggaaatcga ccacgaggac atcaccaagg ataagaccag caccgtggaa gcctgcctgc    1860

ctctggaact gaccaagaac gagtcctgcc tgaacagccg ggaaaccagc ttcatcacca    1920

atggcagctg tctggccagc agaaagacct ccttcatgat ggccctgtgc ctgagcagca    1980

tctacgagga cctgaagatg tatcaggtcg agttcaagac catgaacgcc aagctgctga    2040

tggaccccaa gagacagatt ttcctcgacc agaacatgct ggccgtgatc gatgaactga    2100

tgcaggccct gaacttcaac agcgagacag tgccccagaa gtcctctctg gaagaacccg    2160

acttctacaa gaccaagatc aagctgtgca tcctgctgca cgccttcaga atcagggccg    2220

tgaccatcga cagagtgatg agctatctga acgccagctg aaagcttggt acccaaacaa    2280

acaaaggcgc gtcctggatt cgtggtaaaa cataccagat ttcgatctgg agaggtgaag    2340

aatacgacca cctactacat ccagctgatg agtcccaaat aggacgaaac gcgctcaaac    2400

aaacaaaaga tctcttgttt attgcagctt ataatggtta caaataaagc aatagcatca    2460

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca    2520

tcaatgtatc ttaacgcggc cgcacgtgcg gaccgagcgg ccgcaggaac ccctagtgat    2580

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt    2640

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct    2700

gcagg                                                                2705


<210> 51
<211> 2705
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV.LP1-hIL-12-3'-riboswitch - Sequence with 4nt deletion in
      ITRs; signalpeptide p35-(G4S)3-p40

<400> 51
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgttcgac cccctaaaat gggcaaacat     180

tgcaagcaaa cagcaaacac acagccctcc ctgcctgctg accttggagc tggggcagag     240

gtcagagacc tctctgggcc catgccacct ccaacatcca ctcgacccct tggaatttcg     300

gtggagagga gcagaggttg tcctggcgtg gtttaggtag tgtgagaggg gaatgactcc     360

tttcggtaag tgcagtggaa gctgtacact gcccaggcaa agcgtccggg cagcgtaggc     420

gggcgactca gatcccagcc agtggactta gcccctgttt gctcctccga taactggggt     480

gaccttggtt aatattcacc agcagcctcc cccgttgccc ctctggatcc actgcttaaa     540

tacggacgag gacagggccc tgtctcctca gcttcaggca ccaccactga cctgggacag     600

tgaatccgga ctctaagaga attccccgga ccggtggatc cgccaccatg ggctggtcct     660

gcatcattct gtttctggtg gccacagcca ccggcgtgca ctctagaaac ctgccagtgg     720

ctacccctga tccgggcatg tttccttgtc tgcaccacag ccagaacctg ctgagagccg     780

tgtccaatat gctgcagaag gcccggcaga cccttgagtt ctacccttgc accagcgagg     840

aaatcgacca cgaggacatc accaaggata agaccagcac cgtggaagcc tgcctgcctc     900

tggaactgac caagaacgag tcctgcctga acagccggga aaccagcttc atcaccaatg     960

gcagctgtct ggccagcaga aagacctcct tcatgatggc cctgtgcctg agcagcatct    1020

acgaggacct gaagatgtat caggtcgagt tcaagaccat gaacgccaag ctgctgatgg    1080

accccaagag acagattttc ctcgaccaga acatgctggc cgtgatcgat gaactgatgc    1140

aggccctgaa cttcaacagc gagacagtgc cccagaagtc ctctctggaa gaacccgact    1200

tctacaagac caagatcaag ctgtgcatcc tgctgcacgc cttcagaatc agggccgtga    1260

ccatcgacag agtgatgagc tatctgaacg ccagcggcgg cggaggaagc ggaggcggag    1320

gatctggtgg tggtggaagt atttgggagc tgaagaaaga cgtgtacgtg gtcgagctgg    1380

actggtatcc tgatgctccc ggcgaaatgg tggtgctgac ctgtgataca cccgaagagg    1440

acggcatcac atggacactg gatcagtcta gcgaggtgct cggcagcggc aagacactga    1500

ccatccaagt gaaagagttt ggcgacgccg gccagtacac atgtcacaaa ggcggagagg    1560

tgctgagcca ttctctgctg ctgctccaca agaaagagga tggcatttgg agcaccgaca    1620

tcctgaagga ccagaaagag cccaagaaca agaccttcct gagatgcgag gccaagaact    1680

acagcggcag attcacctgt tggtggctga ccaccatcag caccgatctg accttcagcg    1740

tgaagtccag cagaggcagc tctgatcctc aaggcgttac atgtggcgcc gctacactgt    1800

ctgccgaaag agtgcggggc gacaacaaag agtacgagta cagcgtcgag tgccaagagg    1860

attctgcctg tcctgccgcc gaggaatctc tgcctatcga agtgatggtg gacgccgtgc    1920

acaagctgaa gtacgagaac tacaccagca gctttttcat ccgggacatc atcaagcccg    1980

atcctccaaa gaacctgcag ctgaagcccc tgaagaacag cagacaggtg gaagtgtctt    2040

gggagtaccc cgacacatgg tctacccctc acagctactt cagcctgacc ttctgtgtgc    2100

aagtgcaggg caagtccaag cgcgagaaga aagatcgggt gttcaccgac aagaccagcg    2160

ccaccgtgat ctgcagaaag aacgccagca tcagcgtgcg cgctcaggat aggtactaca    2220

gcagctcttg gagcgagtgg gcctctgttc cttgttcttg aaagcttggt acccaaacaa    2280

acaaaggcgc gtcctggatt cgtggtaaaa cataccagat ttcgatctgg agaggtgaag    2340

aatacgacca cctactacat ccagctgatg agtcccaaat aggacgaaac gcgctcaaac    2400

aaacaaaaga tctcttgttt attgcagctt ataatggtta caaataaagc aatagcatca    2460

caaatttcac aaataaagca tttttttcac tgcattctag ttgtggtttg tccaaactca    2520

tcaatgtatc ttaacgcggc cgcacgtgcg gaccgagcgg ccgcaggaac ccctagtgat    2580

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt    2640

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcagctgcct    2700

gcagg                                                                2705


<210> 52
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> human-immunoglobulin-signal-sequence

<400> 52
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser 
            

<210> 53
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> signal-sequence-p35-p40-huIL12

<400> 53
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            20                  25                  30          
Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        35                  40                  45              
Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    50                  55                  60                  
Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
65                  70                  75                  80  
Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                85                  90                  95      
Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            100                 105                 110         
Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        115                 120                 125             
Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    130                 135                 140                 
Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
145                 150                 155                 160 
Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                165                 170                 175     
Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            180                 185                 190         
Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        195                 200                 205             
Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr 
225                 230                 235                 240 
Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val 
                245                 250                 255     
Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp 
            260                 265                 270         
Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val 
        275                 280                 285             
Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
    290                 295                 300                 
Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile 
305                 310                 315                 320 
Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr 
                325                 330                 335     
Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp 
            340                 345                 350         
Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser 
        355                 360                 365             
Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu 
    370                 375                 380                 
Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val 
385                 390                 395                 400 
Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
                405                 410                 415     
Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
            420                 425                 430         
Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
        435                 440                 445             
Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
    450                 455                 460                 
Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
465                 470                 475                 480 
Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp 
                485                 490                 495     
Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn 
            500                 505                 510         
Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp 
        515                 520                 525             
Ser Glu Trp Ala Ser Val Pro Cys Ser 
    530                 535         

<210> 54
<211> 518
<212> PRT
<213> Artificial Sequence


<220> 
<223> p35-p40-huIL12 (after signal sequence cleavage)

<400> 54
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      
His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          
Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              
His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  
Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  
Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      
Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         
Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             
Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 
Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 
Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     
Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         
Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             
Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu 
    210                 215                 220                 
Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys 
225                 230                 235                 240 
Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser 
                245                 250                 255     
Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe 
            260                 265                 270         
Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser 
        275                 280                 285             
His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
    290                 295                 300                 
Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg 
305                 310                 315                 320 
Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
                325                 330                 335     
Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser 
            340                 345                 350         
Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu 
        355                 360                 365             
Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln 
    370                 375                 380                 
Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val 
385                 390                 395                 400 
Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser 
                405                 410                 415     
Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
            420                 425                 430         
Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr 
        435                 440                 445             
Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys 
    450                 455                 460                 
Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe 
465                 470                 475                 480 
Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile 
                485                 490                 495     
Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp 
            500                 505                 510         
Ala Ser Val Pro Cys Ser 
        515             

<210> 55
<211> 546
<212> PRT
<213> Artificial Sequence


<220> 
<223> >signal-sequence-p35-p40-huIL12-GS_linker

<400> 55
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe 
            20                  25                  30          
Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met 
        35                  40                  45              
Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu 
    50                  55                  60                  
Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu 
65                  70                  75                  80  
Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser 
                85                  90                  95      
Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys 
            100                 105                 110         
Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu 
        115                 120                 125             
Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met 
    130                 135                 140                 
Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile 
145                 150                 155                 160 
Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln 
                165                 170                 175     
Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu 
            180                 185                 190         
Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg 
        195                 200                 205             
Val Met Ser Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    210                 215                 220                 
Gly Ser Gly Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr 
225                 230                 235                 240 
Val Val Glu Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val 
                245                 250                 255     
Leu Thr Cys Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp 
            260                 265                 270         
Gln Ser Ser Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val 
        275                 280                 285             
Lys Glu Phe Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu 
    290                 295                 300                 
Val Leu Ser His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile 
305                 310                 315                 320 
Trp Ser Thr Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr 
                325                 330                 335     
Phe Leu Arg Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp 
            340                 345                 350         
Trp Leu Thr Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser 
        355                 360                 365             
Arg Gly Ser Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu 
    370                 375                 380                 
Ser Ala Glu Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val 
385                 390                 395                 400 
Glu Cys Gln Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro 
                405                 410                 415     
Ile Glu Val Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr 
            420                 425                 430         
Thr Ser Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys 
        435                 440                 445             
Asn Leu Gln Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser 
    450                 455                 460                 
Trp Glu Tyr Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 
465                 470                 475                 480 
Thr Phe Cys Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp 
                485                 490                 495     
Arg Val Phe Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn 
            500                 505                 510         
Ala Ser Ile Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp 
        515                 520                 525             
Ser Glu Trp Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly 
    530                 535                 540                 
Gly Ser 
545     

<210> 56
<211> 527
<212> PRT
<213> Artificial Sequence


<220> 
<223> >p35-p40-huIL12-GS_linker (after signal sequence cleavage)

<400> 56
Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met Phe Pro Cys Leu 
1               5                   10                  15      
His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn Met Leu Gln Lys 
            20                  25                  30          
Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser Glu Glu Ile Asp 
        35                  40                  45              
His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val Glu Ala Cys Leu 
    50                  55                  60                  
Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn Ser Arg Glu Thr 
65                  70                  75                  80  
Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg Lys Thr Ser Phe 
                85                  90                  95      
Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp Leu Lys Met Tyr 
            100                 105                 110         
Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu Met Asp Pro Lys 
        115                 120                 125             
Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val Ile Asp Glu Leu 
    130                 135                 140                 
Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro Gln Lys Ser Ser 
145                 150                 155                 160 
Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys Leu Cys Ile Leu 
                165                 170                 175     
Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp Arg Val Met Ser 
            180                 185                 190         
Tyr Leu Asn Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        195                 200                 205             
Gly Gly Gly Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu 
    210                 215                 220                 
Leu Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys 
225                 230                 235                 240 
Asp Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser 
                245                 250                 255     
Glu Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe 
            260                 265                 270         
Gly Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser 
        275                 280                 285             
His Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr 
    290                 295                 300                 
Asp Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg 
305                 310                 315                 320 
Cys Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr 
                325                 330                 335     
Thr Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser 
            340                 345                 350         
Ser Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu 
        355                 360                 365             
Arg Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln 
    370                 375                 380                 
Glu Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val 
385                 390                 395                 400 
Met Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser 
                405                 410                 415     
Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln 
            420                 425                 430         
Leu Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr 
        435                 440                 445             
Pro Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys 
    450                 455                 460                 
Val Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe 
465                 470                 475                 480 
Thr Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile 
                485                 490                 495     
Ser Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp 
            500                 505                 510         
Ala Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
        515                 520                 525         

<210> 57
<211> 2713
<212> DNA
<213> Artificial Sequence


<220> 
<223> > AAV.LP1-hIL-12-3’-riboswitch: signalpeptide, IL12
      p40-(G4S)3-p35; AAV2-WT ITR

<400> 57
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     120

gccaactcca tcactagggg ttcctgcggc cgcacgcgtt cgacccccta aaatgggcaa     180

acattgcaag caaacagcaa acacacagcc ctccctgcct gctgaccttg gagctggggc     240

agaggtcaga gacctctctg ggcccatgcc acctccaaca tccactcgac cccttggaat     300

ttcggtggag aggagcagag gttgtcctgg cgtggtttag gtagtgtgag aggggaatga     360

ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt     420

aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg     480

gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct     540

taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg     600

acagtgaatc cggactctaa gagaattccc cggaccggtg gatccgccac catgggctgg     660

tcctgcatca ttctgtttct ggtggccaca gccaccggcg tgcactctat ttgggagctg     720

aagaaagacg tgtacgtggt cgagctggac tggtatcctg atgctcccgg cgaaatggtg     780

gtgctgacct gtgatacacc cgaagaggac ggcatcacat ggacactgga tcagtctagc     840

gaggtgctcg gcagcggcaa gacactgacc atccaagtga aagagtttgg cgacgccggc     900

cagtacacat gtcacaaagg cggagaggtg ctgagccatt ctctgctgct gctccacaag     960

aaagaggatg gcatttggag caccgacatc ctgaaggacc agaaagagcc caagaacaag    1020

accttcctga gatgcgaggc caagaactac agcggcagat tcacctgttg gtggctgacc    1080

accatcagca ccgatctgac cttcagcgtg aagtccagca gaggcagctc tgatcctcaa    1140

ggcgttacat gtggcgccgc tacactgtct gccgaaagag tgcggggcga caacaaagag    1200

tacgagtaca gcgtcgagtg ccaagaggat tctgcctgtc ctgccgccga ggaatctctg    1260

cctatcgaag tgatggtgga cgccgtgcac aagctgaagt acgagaacta caccagcagc    1320

tttttcatcc gggacatcat caagcccgat cctccaaaga acctgcagct gaagcccctg    1380

aagaacagca gacaggtgga agtgtcttgg gagtaccccg acacatggtc tacccctcac    1440

agctacttca gcctgacctt ctgtgtgcaa gtgcagggca agtccaagcg cgagaagaaa    1500

gatcgggtgt tcaccgacaa gaccagcgcc accgtgatct gcagaaagaa cgccagcatc    1560

agcgtgcgcg ctcaggatag gtactacagc agctcttgga gcgagtgggc ctctgttcct    1620

tgttctggcg gcggaggaag cggaggcgga ggatctggtg gtggtggaag tagaaacctg    1680

ccagtggcta cccctgatcc gggcatgttt ccttgtctgc accacagcca gaacctgctg    1740

agagccgtgt ccaatatgct gcagaaggcc cggcagaccc ttgagttcta cccttgcacc    1800

agcgaggaaa tcgaccacga ggacatcacc aaggataaga ccagcaccgt ggaagcctgc    1860

ctgcctctgg aactgaccaa gaacgagtcc tgcctgaaca gccgggaaac cagcttcatc    1920

accaatggca gctgtctggc cagcagaaag acctccttca tgatggccct gtgcctgagc    1980

agcatctacg aggacctgaa gatgtatcag gtcgagttca agaccatgaa cgccaagctg    2040

ctgatggacc ccaagagaca gattttcctc gaccagaaca tgctggccgt gatcgatgaa    2100

ctgatgcagg ccctgaactt caacagcgag acagtgcccc agaagtcctc tctggaagaa    2160

cccgacttct acaagaccaa gatcaagctg tgcatcctgc tgcacgcctt cagaatcagg    2220

gccgtgacca tcgacagagt gatgagctat ctgaacgcca gctgaaagct tggtacccaa    2280

acaaacaaag gcgcgtcctg gattcgtggt aaaacatacc agatttcgat ctggagaggt    2340

gaagaatacg accacctact acatccagct gatgagtccc aaataggacg aaacgcgctc    2400

aaacaaacaa aagatctctt gtttattgca gcttataatg gttacaaata aagcaatagc    2460

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa    2520

ctcatcaatg tatcttaacg cggccgcacg tgcggaccga gcggccgcag gaacccctag    2580

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggcaa    2640

agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag    2700

agggagtggc caa                                                       2713


<210> 58
<211> 2713
<212> DNA
<213> Artificial Sequence


<220> 
<223> > pAAV.LP1-hIL-12-3’-riboswitch; signalpeptide, IL12
      p35-(G4S)3-p40; AAV2-WT ITR

<400> 58
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     120

gccaactcca tcactagggg ttcctgcggc cgcacgcgtt cgacccccta aaatgggcaa     180

acattgcaag caaacagcaa acacacagcc ctccctgcct gctgaccttg gagctggggc     240

agaggtcaga gacctctctg ggcccatgcc acctccaaca tccactcgac cccttggaat     300

ttcggtggag aggagcagag gttgtcctgg cgtggtttag gtagtgtgag aggggaatga     360

ctcctttcgg taagtgcagt ggaagctgta cactgcccag gcaaagcgtc cgggcagcgt     420

aggcgggcga ctcagatccc agccagtgga cttagcccct gtttgctcct ccgataactg     480

gggtgacctt ggttaatatt caccagcagc ctcccccgtt gcccctctgg atccactgct     540

taaatacgga cgaggacagg gccctgtctc ctcagcttca ggcaccacca ctgacctggg     600

acagtgaatc cggactctaa gagaattccc cggaccggtg gatccgccac catgggctgg     660

tcctgcatca ttctgtttct ggtggccaca gccaccggcg tgcactctag aaacctgcca     720

gtggctaccc ctgatccggg catgtttcct tgtctgcacc acagccagaa cctgctgaga     780

gccgtgtcca atatgctgca gaaggcccgg cagacccttg agttctaccc ttgcaccagc     840

gaggaaatcg accacgagga catcaccaag gataagacca gcaccgtgga agcctgcctg     900

cctctggaac tgaccaagaa cgagtcctgc ctgaacagcc gggaaaccag cttcatcacc     960

aatggcagct gtctggccag cagaaagacc tccttcatga tggccctgtg cctgagcagc    1020

atctacgagg acctgaagat gtatcaggtc gagttcaaga ccatgaacgc caagctgctg    1080

atggacccca agagacagat tttcctcgac cagaacatgc tggccgtgat cgatgaactg    1140

atgcaggccc tgaacttcaa cagcgagaca gtgccccaga agtcctctct ggaagaaccc    1200

gacttctaca agaccaagat caagctgtgc atcctgctgc acgccttcag aatcagggcc    1260

gtgaccatcg acagagtgat gagctatctg aacgccagcg gcggcggagg aagcggaggc    1320

ggaggatctg gtggtggtgg aagtatttgg gagctgaaga aagacgtgta cgtggtcgag    1380

ctggactggt atcctgatgc tcccggcgaa atggtggtgc tgacctgtga tacacccgaa    1440

gaggacggca tcacatggac actggatcag tctagcgagg tgctcggcag cggcaagaca    1500

ctgaccatcc aagtgaaaga gtttggcgac gccggccagt acacatgtca caaaggcgga    1560

gaggtgctga gccattctct gctgctgctc cacaagaaag aggatggcat ttggagcacc    1620

gacatcctga aggaccagaa agagcccaag aacaagacct tcctgagatg cgaggccaag    1680

aactacagcg gcagattcac ctgttggtgg ctgaccacca tcagcaccga tctgaccttc    1740

agcgtgaagt ccagcagagg cagctctgat cctcaaggcg ttacatgtgg cgccgctaca    1800

ctgtctgccg aaagagtgcg gggcgacaac aaagagtacg agtacagcgt cgagtgccaa    1860

gaggattctg cctgtcctgc cgccgaggaa tctctgccta tcgaagtgat ggtggacgcc    1920

gtgcacaagc tgaagtacga gaactacacc agcagctttt tcatccggga catcatcaag    1980

cccgatcctc caaagaacct gcagctgaag cccctgaaga acagcagaca ggtggaagtg    2040

tcttgggagt accccgacac atggtctacc cctcacagct acttcagcct gaccttctgt    2100

gtgcaagtgc agggcaagtc caagcgcgag aagaaagatc gggtgttcac cgacaagacc    2160

agcgccaccg tgatctgcag aaagaacgcc agcatcagcg tgcgcgctca ggataggtac    2220

tacagcagct cttggagcga gtgggcctct gttccttgtt cttgaaagct tggtacccaa    2280

acaaacaaag gcgcgtcctg gattcgtggt aaaacatacc agatttcgat ctggagaggt    2340

gaagaatacg accacctact acatccagct gatgagtccc aaataggacg aaacgcgctc    2400

aaacaaacaa aagatctctt gtttattgca gcttataatg gttacaaata aagcaatagc    2460

atcacaaatt tcacaaataa agcatttttt tcactgcatt ctagttgtgg tttgtccaaa    2520

ctcatcaatg tatcttaacg cggccgcacg tgcggaccga gcggccgcag gaacccctag    2580

tgatggagtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gcccgggcaa    2640

agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt gagcgagcga gcgcgcagag    2700

agggagtggc caa                                                       2713


<210> 59
<211> 2911
<212> DNA
<213> Artificial Sequence


<220> 
<223> > AAV.LP1_SV40-hIL-12-3’-riboswitch: signalpeptide, IL12
      p40-(G4S)3-p35; AAV2-WT ITR

<400> 59
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     120

gccaactcca tcactagggg ttcctgcggc cgcacgcgtc cctaaaatgg gcaaacattg     180

caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga     240

ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc     300

ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg gtccgggttc     360

aaaaccactt gctgggtggg gagtcgtcag taagtggcta tgccccgacc ccgaagcctg     420

tttccccatc tgtacaatgg aaatgataaa gacgcccatc tgatagggaa tgactccttt     480

cggtaagtgc agtggaagct gtacactgcc caggcaaagc gtccgggcag cgtaggcggg     540

cgactcagat cccagccagt ggacttagcc cctgtttgct cctccgataa ctggggtgac     600

cttggttaat attcaccagc agcctccccc gttgcccctc tggatccact gcttaaatac     660

ggacgaggac agggccctgt ctcctcagct tcaggcacca ccactgacct gggacagtga     720

atccggactc taaggtaaat ataaaatttt taagtgtata atgtgttaaa ctactgattc     780

taattgtttc tctattttag attccaacct ttggaactga gaattccccg gaccggtgga     840

tccgccacca tgggctggtc ctgcatcatt ctgtttctgg tggccacagc caccggcgtg     900

cactctattt gggagctgaa gaaagacgtg tacgtggtcg agctggactg gtatcctgat     960

gctcccggcg aaatggtggt gctgacctgt gatacacccg aagaggacgg catcacatgg    1020

acactggatc agtctagcga ggtgctcggc agcggcaaga cactgaccat ccaagtgaaa    1080

gagtttggcg acgccggcca gtacacatgt cacaaaggcg gagaggtgct gagccattct    1140

ctgctgctgc tccacaagaa agaggatggc atttggagca ccgacatcct gaaggaccag    1200

aaagagccca agaacaagac cttcctgaga tgcgaggcca agaactacag cggcagattc    1260

acctgttggt ggctgaccac catcagcacc gatctgacct tcagcgtgaa gtccagcaga    1320

ggcagctctg atcctcaagg cgttacatgt ggcgccgcta cactgtctgc cgaaagagtg    1380

cggggcgaca acaaagagta cgagtacagc gtcgagtgcc aagaggattc tgcctgtcct    1440

gccgccgagg aatctctgcc tatcgaagtg atggtggacg ccgtgcacaa gctgaagtac    1500

gagaactaca ccagcagctt tttcatccgg gacatcatca agcccgatcc tccaaagaac    1560

ctgcagctga agcccctgaa gaacagcaga caggtggaag tgtcttggga gtaccccgac    1620

acatggtcta cccctcacag ctacttcagc ctgaccttct gtgtgcaagt gcagggcaag    1680

tccaagcgcg agaagaaaga tcgggtgttc accgacaaga ccagcgccac cgtgatctgc    1740

agaaagaacg ccagcatcag cgtgcgcgct caggataggt actacagcag ctcttggagc    1800

gagtgggcct ctgttccttg ttctggcggc ggaggaagcg gaggcggagg atctggtggt    1860

ggtggaagta gaaacctgcc agtggctacc cctgatccgg gcatgtttcc ttgtctgcac    1920

cacagccaga acctgctgag agccgtgtcc aatatgctgc agaaggcccg gcagaccctt    1980

gagttctacc cttgcaccag cgaggaaatc gaccacgagg acatcaccaa ggataagacc    2040

agcaccgtgg aagcctgcct gcctctggaa ctgaccaaga acgagtcctg cctgaacagc    2100

cgggaaacca gcttcatcac caatggcagc tgtctggcca gcagaaagac ctccttcatg    2160

atggccctgt gcctgagcag catctacgag gacctgaaga tgtatcaggt cgagttcaag    2220

accatgaacg ccaagctgct gatggacccc aagagacaga ttttcctcga ccagaacatg    2280

ctggccgtga tcgatgaact gatgcaggcc ctgaacttca acagcgagac agtgccccag    2340

aagtcctctc tggaagaacc cgacttctac aagaccaaga tcaagctgtg catcctgctg    2400

cacgccttca gaatcagggc cgtgaccatc gacagagtga tgagctatct gaacgccagc    2460

tgaaagcttg gtacccaaac aaacaaaggc gcgtcctgga ttcgtggtaa aacataccag    2520

atttcgatct ggagaggtga agaatacgac cacctactac atccagctga tgagtcccaa    2580

ataggacgaa acgcgctcaa acaaacaaaa gatctcttgt ttattgcagc ttataatggt    2640

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct    2700

agttgtggtt tgtccaaact catcaatgta tcttaacgcg gccgcacgtg cggaccgagc    2760

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca    2820

ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga    2880

gcgagcgagc gcgcagagag ggagtggcca a                                   2911


<210> 60
<211> 2911
<212> DNA
<213> Artificial Sequence


<220> 
<223> > pAAV.LP1_SV40-hIL-12-3’-riboswitch: signalpeptide, IL12
      p35-(G4S)3-p40; AAV2-WT ITR

<400> 60
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc      60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg     120

gccaactcca tcactagggg ttcctgcggc cgcacgcgtc cctaaaatgg gcaaacattg     180

caagcagcaa acagcaaaca cacagccctc cctgcctgct gaccttggag ctggggcaga     240

ggtcagagac ctctctgggc ccatgccacc tccaacatcc actcgacccc ttggaatttc     300

ggtggagagg agcagaggtt gtcctggcgt ggtttaggta gtgtgagagg gtccgggttc     360

aaaaccactt gctgggtggg gagtcgtcag taagtggcta tgccccgacc ccgaagcctg     420

tttccccatc tgtacaatgg aaatgataaa gacgcccatc tgatagggaa tgactccttt     480

cggtaagtgc agtggaagct gtacactgcc caggcaaagc gtccgggcag cgtaggcggg     540

cgactcagat cccagccagt ggacttagcc cctgtttgct cctccgataa ctggggtgac     600

cttggttaat attcaccagc agcctccccc gttgcccctc tggatccact gcttaaatac     660

ggacgaggac agggccctgt ctcctcagct tcaggcacca ccactgacct gggacagtga     720

atccggactc taaggtaaat ataaaatttt taagtgtata atgtgttaaa ctactgattc     780

taattgtttc tctattttag attccaacct ttggaactga gaattccccg gaccggtgga     840

tccgccacca tgggctggtc ctgcatcatt ctgtttctgg tggccacagc caccggcgtg     900

cactctagaa acctgccagt ggctacccct gatccgggca tgtttccttg tctgcaccac     960

agccagaacc tgctgagagc cgtgtccaat atgctgcaga aggcccggca gacccttgag    1020

ttctaccctt gcaccagcga ggaaatcgac cacgaggaca tcaccaagga taagaccagc    1080

accgtggaag cctgcctgcc tctggaactg accaagaacg agtcctgcct gaacagccgg    1140

gaaaccagct tcatcaccaa tggcagctgt ctggccagca gaaagacctc cttcatgatg    1200

gccctgtgcc tgagcagcat ctacgaggac ctgaagatgt atcaggtcga gttcaagacc    1260

atgaacgcca agctgctgat ggaccccaag agacagattt tcctcgacca gaacatgctg    1320

gccgtgatcg atgaactgat gcaggccctg aacttcaaca gcgagacagt gccccagaag    1380

tcctctctgg aagaacccga cttctacaag accaagatca agctgtgcat cctgctgcac    1440

gccttcagaa tcagggccgt gaccatcgac agagtgatga gctatctgaa cgccagcggc    1500

ggcggaggaa gcggaggcgg aggatctggt ggtggtggaa gtatttggga gctgaagaaa    1560

gacgtgtacg tggtcgagct ggactggtat cctgatgctc ccggcgaaat ggtggtgctg    1620

acctgtgata cacccgaaga ggacggcatc acatggacac tggatcagtc tagcgaggtg    1680

ctcggcagcg gcaagacact gaccatccaa gtgaaagagt ttggcgacgc cggccagtac    1740

acatgtcaca aaggcggaga ggtgctgagc cattctctgc tgctgctcca caagaaagag    1800

gatggcattt ggagcaccga catcctgaag gaccagaaag agcccaagaa caagaccttc    1860

ctgagatgcg aggccaagaa ctacagcggc agattcacct gttggtggct gaccaccatc    1920

agcaccgatc tgaccttcag cgtgaagtcc agcagaggca gctctgatcc tcaaggcgtt    1980

acatgtggcg ccgctacact gtctgccgaa agagtgcggg gcgacaacaa agagtacgag    2040

tacagcgtcg agtgccaaga ggattctgcc tgtcctgccg ccgaggaatc tctgcctatc    2100

gaagtgatgg tggacgccgt gcacaagctg aagtacgaga actacaccag cagctttttc    2160

atccgggaca tcatcaagcc cgatcctcca aagaacctgc agctgaagcc cctgaagaac    2220

agcagacagg tggaagtgtc ttgggagtac cccgacacat ggtctacccc tcacagctac    2280

ttcagcctga ccttctgtgt gcaagtgcag ggcaagtcca agcgcgagaa gaaagatcgg    2340

gtgttcaccg acaagaccag cgccaccgtg atctgcagaa agaacgccag catcagcgtg    2400

cgcgctcagg ataggtacta cagcagctct tggagcgagt gggcctctgt tccttgttct    2460

tgaaagcttg gtacccaaac aaacaaaggc gcgtcctgga ttcgtggtaa aacataccag    2520

atttcgatct ggagaggtga agaatacgac cacctactac atccagctga tgagtcccaa    2580

ataggacgaa acgcgctcaa acaaacaaaa gatctcttgt ttattgcagc ttataatggt    2640

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct    2700

agttgtggtt tgtccaaact catcaatgta tcttaacgcg gccgcacgtg cggaccgagc    2760

ggccgcagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca    2820

ctgaggccgc ccgggcaaag cccgggcgtc gggcgacctt tggtcgcccg gcctcagtga    2880

gcgagcgagc gcgcagagag ggagtggcca a                                   2911


<210> 61
<211> 2903
<212> DNA
<213> Artificial Sequence


<220> 
<223> > AAV.LP1_SV40-hIL-12-3’-riboswitch: signalpeptide, IL12
      p40-(G4S)3-p35; carrying the 4nt deletion in the ITR

<400> 61
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgtcccta aaatgggcaa acattgcaag     180

cagcaaacag caaacacaca gccctccctg cctgctgacc ttggagctgg ggcagaggtc     240

agagacctct ctgggcccat gccacctcca acatccactc gaccccttgg aatttcggtg     300

gagaggagca gaggttgtcc tggcgtggtt taggtagtgt gagagggtcc gggttcaaaa     360

ccacttgctg ggtggggagt cgtcagtaag tggctatgcc ccgaccccga agcctgtttc     420

cccatctgta caatggaaat gataaagacg cccatctgat agggaatgac tcctttcggt     480

aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta ggcgggcgac     540

tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg ggtgaccttg     600

gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt aaatacggac     660

gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga cagtgaatcc     720

ggactctaag gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat     780

tgtttctcta ttttagattc caacctttgg aactgagaat tccccggacc ggtggatccg     840

ccaccatggg ctggtcctgc atcattctgt ttctggtggc cacagccacc ggcgtgcact     900

ctatttggga gctgaagaaa gacgtgtacg tggtcgagct ggactggtat cctgatgctc     960

ccggcgaaat ggtggtgctg acctgtgata cacccgaaga ggacggcatc acatggacac    1020

tggatcagtc tagcgaggtg ctcggcagcg gcaagacact gaccatccaa gtgaaagagt    1080

ttggcgacgc cggccagtac acatgtcaca aaggcggaga ggtgctgagc cattctctgc    1140

tgctgctcca caagaaagag gatggcattt ggagcaccga catcctgaag gaccagaaag    1200

agcccaagaa caagaccttc ctgagatgcg aggccaagaa ctacagcggc agattcacct    1260

gttggtggct gaccaccatc agcaccgatc tgaccttcag cgtgaagtcc agcagaggca    1320

gctctgatcc tcaaggcgtt acatgtggcg ccgctacact gtctgccgaa agagtgcggg    1380

gcgacaacaa agagtacgag tacagcgtcg agtgccaaga ggattctgcc tgtcctgccg    1440

ccgaggaatc tctgcctatc gaagtgatgg tggacgccgt gcacaagctg aagtacgaga    1500

actacaccag cagctttttc atccgggaca tcatcaagcc cgatcctcca aagaacctgc    1560

agctgaagcc cctgaagaac agcagacagg tggaagtgtc ttgggagtac cccgacacat    1620

ggtctacccc tcacagctac ttcagcctga ccttctgtgt gcaagtgcag ggcaagtcca    1680

agcgcgagaa gaaagatcgg gtgttcaccg acaagaccag cgccaccgtg atctgcagaa    1740

agaacgccag catcagcgtg cgcgctcagg ataggtacta cagcagctct tggagcgagt    1800

gggcctctgt tccttgttct ggcggcggag gaagcggagg cggaggatct ggtggtggtg    1860

gaagtagaaa cctgccagtg gctacccctg atccgggcat gtttccttgt ctgcaccaca    1920

gccagaacct gctgagagcc gtgtccaata tgctgcagaa ggcccggcag acccttgagt    1980

tctacccttg caccagcgag gaaatcgacc acgaggacat caccaaggat aagaccagca    2040

ccgtggaagc ctgcctgcct ctggaactga ccaagaacga gtcctgcctg aacagccggg    2100

aaaccagctt catcaccaat ggcagctgtc tggccagcag aaagacctcc ttcatgatgg    2160

ccctgtgcct gagcagcatc tacgaggacc tgaagatgta tcaggtcgag ttcaagacca    2220

tgaacgccaa gctgctgatg gaccccaaga gacagatttt cctcgaccag aacatgctgg    2280

ccgtgatcga tgaactgatg caggccctga acttcaacag cgagacagtg ccccagaagt    2340

cctctctgga agaacccgac ttctacaaga ccaagatcaa gctgtgcatc ctgctgcacg    2400

ccttcagaat cagggccgtg accatcgaca gagtgatgag ctatctgaac gccagctgaa    2460

agcttggtac ccaaacaaac aaaggcgcgt cctggattcg tggtaaaaca taccagattt    2520

cgatctggag aggtgaagaa tacgaccacc tactacatcc agctgatgag tcccaaatag    2580

gacgaaacgc gctcaaacaa acaaaagatc tcttgtttat tgcagcttat aatggttaca    2640

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt    2700

gtggtttgtc caaactcatc aatgtatctt aacgcggccg cacgtgcgga ccgagcggcc    2760

gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga    2820

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga    2880

gcgagcgcgc agctgcctgc agg                                            2903


<210> 62
<211> 2903
<212> DNA
<213> Artificial Sequence


<220> 
<223> > pAAV. LP1_SV40-hIL-12-3’riboswitch; signalpeptide, IL12
      p35(G4S)3p40; carrying the 4nt deletion in the ITR

<400> 62
cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc      60

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     120

actccatcac taggggttcc tgcggccgca cgcgtcccta aaatgggcaa acattgcaag     180

cagcaaacag caaacacaca gccctccctg cctgctgacc ttggagctgg ggcagaggtc     240

agagacctct ctgggcccat gccacctcca acatccactc gaccccttgg aatttcggtg     300

gagaggagca gaggttgtcc tggcgtggtt taggtagtgt gagagggtcc gggttcaaaa     360

ccacttgctg ggtggggagt cgtcagtaag tggctatgcc ccgaccccga agcctgtttc     420

cccatctgta caatggaaat gataaagacg cccatctgat agggaatgac tcctttcggt     480

aagtgcagtg gaagctgtac actgcccagg caaagcgtcc gggcagcgta ggcgggcgac     540

tcagatccca gccagtggac ttagcccctg tttgctcctc cgataactgg ggtgaccttg     600

gttaatattc accagcagcc tcccccgttg cccctctgga tccactgctt aaatacggac     660

gaggacaggg ccctgtctcc tcagcttcag gcaccaccac tgacctggga cagtgaatcc     720

ggactctaag gtaaatataa aatttttaag tgtataatgt gttaaactac tgattctaat     780

tgtttctcta ttttagattc caacctttgg aactgagaat tccccggacc ggtggatccg     840

ccaccatggg ctggtcctgc atcattctgt ttctggtggc cacagccacc ggcgtgcact     900

ctagaaacct gccagtggct acccctgatc cgggcatgtt tccttgtctg caccacagcc     960

agaacctgct gagagccgtg tccaatatgc tgcagaaggc ccggcagacc cttgagttct    1020

acccttgcac cagcgaggaa atcgaccacg aggacatcac caaggataag accagcaccg    1080

tggaagcctg cctgcctctg gaactgacca agaacgagtc ctgcctgaac agccgggaaa    1140

ccagcttcat caccaatggc agctgtctgg ccagcagaaa gacctccttc atgatggccc    1200

tgtgcctgag cagcatctac gaggacctga agatgtatca ggtcgagttc aagaccatga    1260

acgccaagct gctgatggac cccaagagac agattttcct cgaccagaac atgctggccg    1320

tgatcgatga actgatgcag gccctgaact tcaacagcga gacagtgccc cagaagtcct    1380

ctctggaaga acccgacttc tacaagacca agatcaagct gtgcatcctg ctgcacgcct    1440

tcagaatcag ggccgtgacc atcgacagag tgatgagcta tctgaacgcc agcggcggcg    1500

gaggaagcgg aggcggagga tctggtggtg gtggaagtat ttgggagctg aagaaagacg    1560

tgtacgtggt cgagctggac tggtatcctg atgctcccgg cgaaatggtg gtgctgacct    1620

gtgatacacc cgaagaggac ggcatcacat ggacactgga tcagtctagc gaggtgctcg    1680

gcagcggcaa gacactgacc atccaagtga aagagtttgg cgacgccggc cagtacacat    1740

gtcacaaagg cggagaggtg ctgagccatt ctctgctgct gctccacaag aaagaggatg    1800

gcatttggag caccgacatc ctgaaggacc agaaagagcc caagaacaag accttcctga    1860

gatgcgaggc caagaactac agcggcagat tcacctgttg gtggctgacc accatcagca    1920

ccgatctgac cttcagcgtg aagtccagca gaggcagctc tgatcctcaa ggcgttacat    1980

gtggcgccgc tacactgtct gccgaaagag tgcggggcga caacaaagag tacgagtaca    2040

gcgtcgagtg ccaagaggat tctgcctgtc ctgccgccga ggaatctctg cctatcgaag    2100

tgatggtgga cgccgtgcac aagctgaagt acgagaacta caccagcagc tttttcatcc    2160

gggacatcat caagcccgat cctccaaaga acctgcagct gaagcccctg aagaacagca    2220

gacaggtgga agtgtcttgg gagtaccccg acacatggtc tacccctcac agctacttca    2280

gcctgacctt ctgtgtgcaa gtgcagggca agtccaagcg cgagaagaaa gatcgggtgt    2340

tcaccgacaa gaccagcgcc accgtgatct gcagaaagaa cgccagcatc agcgtgcgcg    2400

ctcaggatag gtactacagc agctcttgga gcgagtgggc ctctgttcct tgttcttgaa    2460

agcttggtac ccaaacaaac aaaggcgcgt cctggattcg tggtaaaaca taccagattt    2520

cgatctggag aggtgaagaa tacgaccacc tactacatcc agctgatgag tcccaaatag    2580

gacgaaacgc gctcaaacaa acaaaagatc tcttgtttat tgcagcttat aatggttaca    2640

aataaagcaa tagcatcaca aatttcacaa ataaagcatt tttttcactg cattctagtt    2700

gtggtttgtc caaactcatc aatgtatctt aacgcggccg cacgtgcgga ccgagcggcc    2760

gcaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga    2820

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga    2880

gcgagcgcgc agctgcctgc agg                                            2903


<210> 63
<211> 2892
<212> DNA
<213> Artificial Sequence


<220> 
<223> > AAV.LP1_SV40-hIL-12-3’-riboswitch: signalpeptide, IL12
      p40-(G4S)3-p35; carrying the 11nt deletion in the left ITR, and
      the 4nt deletion in the right ITR

<400> 63
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg      60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcagc     120

tgcctgcagg gcggccgcac gcgtccctaa aatgggcaaa cattgcaagc agcaaacagc     180

aaacacacag ccctccctgc ctgctgacct tggagctggg gcagaggtca gagacctctc     240

tgggcccatg ccacctccaa catccactcg accccttgga atttcggtgg agaggagcag     300

aggttgtcct ggcgtggttt aggtagtgtg agagggtccg ggttcaaaac cacttgctgg     360

gtggggagtc gtcagtaagt ggctatgccc cgaccccgaa gcctgtttcc ccatctgtac     420

aatggaaatg ataaagacgc ccatctgata gggaatgact cctttcggta agtgcagtgg     480

aagctgtaca ctgcccaggc aaagcgtccg ggcagcgtag gcgggcgact cagatcccag     540

ccagtggact tagcccctgt ttgctcctcc gataactggg gtgaccttgg ttaatattca     600

ccagcagcct cccccgttgc ccctctggat ccactgctta aatacggacg aggacagggc     660

cctgtctcct cagcttcagg caccaccact gacctgggac agtgaatccg gactctaagg     720

taaatataaa atttttaagt gtataatgtg ttaaactact gattctaatt gtttctctat     780

tttagattcc aacctttgga actgagaatt ccccggaccg gtggatccgc caccatgggc     840

tggtcctgca tcattctgtt tctggtggcc acagccaccg gcgtgcactc tatttgggag     900

ctgaagaaag acgtgtacgt ggtcgagctg gactggtatc ctgatgctcc cggcgaaatg     960

gtggtgctga cctgtgatac acccgaagag gacggcatca catggacact ggatcagtct    1020

agcgaggtgc tcggcagcgg caagacactg accatccaag tgaaagagtt tggcgacgcc    1080

ggccagtaca catgtcacaa aggcggagag gtgctgagcc attctctgct gctgctccac    1140

aagaaagagg atggcatttg gagcaccgac atcctgaagg accagaaaga gcccaagaac    1200

aagaccttcc tgagatgcga ggccaagaac tacagcggca gattcacctg ttggtggctg    1260

accaccatca gcaccgatct gaccttcagc gtgaagtcca gcagaggcag ctctgatcct    1320

caaggcgtta catgtggcgc cgctacactg tctgccgaaa gagtgcgggg cgacaacaaa    1380

gagtacgagt acagcgtcga gtgccaagag gattctgcct gtcctgccgc cgaggaatct    1440

ctgcctatcg aagtgatggt ggacgccgtg cacaagctga agtacgagaa ctacaccagc    1500

agctttttca tccgggacat catcaagccc gatcctccaa agaacctgca gctgaagccc    1560

ctgaagaaca gcagacaggt ggaagtgtct tgggagtacc ccgacacatg gtctacccct    1620

cacagctact tcagcctgac cttctgtgtg caagtgcagg gcaagtccaa gcgcgagaag    1680

aaagatcggg tgttcaccga caagaccagc gccaccgtga tctgcagaaa gaacgccagc    1740

atcagcgtgc gcgctcagga taggtactac agcagctctt ggagcgagtg ggcctctgtt    1800

ccttgttctg gcggcggagg aagcggaggc ggaggatctg gtggtggtgg aagtagaaac    1860

ctgccagtgg ctacccctga tccgggcatg tttccttgtc tgcaccacag ccagaacctg    1920

ctgagagccg tgtccaatat gctgcagaag gcccggcaga cccttgagtt ctacccttgc    1980

accagcgagg aaatcgacca cgaggacatc accaaggata agaccagcac cgtggaagcc    2040

tgcctgcctc tggaactgac caagaacgag tcctgcctga acagccggga aaccagcttc    2100

atcaccaatg gcagctgtct ggccagcaga aagacctcct tcatgatggc cctgtgcctg    2160

agcagcatct acgaggacct gaagatgtat caggtcgagt tcaagaccat gaacgccaag    2220

ctgctgatgg accccaagag acagattttc ctcgaccaga acatgctggc cgtgatcgat    2280

gaactgatgc aggccctgaa cttcaacagc gagacagtgc cccagaagtc ctctctggaa    2340

gaacccgact tctacaagac caagatcaag ctgtgcatcc tgctgcacgc cttcagaatc    2400

agggccgtga ccatcgacag agtgatgagc tatctgaacg ccagctgaaa gcttggtacc    2460

caaacaaaca aaggcgcgtc ctggattcgt ggtaaaacat accagatttc gatctggaga    2520

ggtgaagaat acgaccacct actacatcca gctgatgagt cccaaatagg acgaaacgcg    2580

ctcaaacaaa caaaagatct cttgtttatt gcagcttata atggttacaa ataaagcaat    2640

agcatcacaa atttcacaaa taaagcattt ttttcactgc attctagttg tggtttgtcc    2700

aaactcatca atgtatctta acgcggccgc acgtgcggac cgagcggccg caggaacccc    2760

tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag gccgggcgac    2820

caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag cgagcgcgca    2880

gctgcctgca gg                                                        2892


<210> 64
<211> 2694
<212> DNA
<213> Artificial Sequence


<220> 
<223> > AAV. LP1_SV40-hIL-12-3’riboswitch; signalpeptide, IL12
      p35(G4S)3p40; carrying the 11nt deletion in the left ITR, and the
      4nt deletion in the right ITR

<400> 64
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg      60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcagc     120

tgcctgcagg gcggccgcac gcgttcgacc ccctaaaatg ggcaaacatt gcaagcaaac     180

agcaaacaca cagccctccc tgcctgctga ccttggagct ggggcagagg tcagagacct     240

ctctgggccc atgccacctc caacatccac tcgacccctt ggaatttcgg tggagaggag     300

cagaggttgt cctggcgtgg tttaggtagt gtgagagggg aatgactcct ttcggtaagt     360

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     420

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     480

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     540

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt gaatccggac     600

tctaagagaa ttccccggac cggtggatcc gccaccatgg gctggtcctg catcattctg     660

tttctggtgg ccacagccac cggcgtgcac tctatttggg agctgaagaa agacgtgtac     720

gtggtcgagc tggactggta tcctgatgct cccggcgaaa tggtggtgct gacctgtgat     780

acacccgaag aggacggcat cacatggaca ctggatcagt ctagcgaggt gctcggcagc     840

ggcaagacac tgaccatcca agtgaaagag tttggcgacg ccggccagta cacatgtcac     900

aaaggcggag aggtgctgag ccattctctg ctgctgctcc acaagaaaga ggatggcatt     960

tggagcaccg acatcctgaa ggaccagaaa gagcccaaga acaagacctt cctgagatgc    1020

gaggccaaga actacagcgg cagattcacc tgttggtggc tgaccaccat cagcaccgat    1080

ctgaccttca gcgtgaagtc cagcagaggc agctctgatc ctcaaggcgt tacatgtggc    1140

gccgctacac tgtctgccga aagagtgcgg ggcgacaaca aagagtacga gtacagcgtc    1200

gagtgccaag aggattctgc ctgtcctgcc gccgaggaat ctctgcctat cgaagtgatg    1260

gtggacgccg tgcacaagct gaagtacgag aactacacca gcagcttttt catccgggac    1320

atcatcaagc ccgatcctcc aaagaacctg cagctgaagc ccctgaagaa cagcagacag    1380

gtggaagtgt cttgggagta ccccgacaca tggtctaccc ctcacagcta cttcagcctg    1440

accttctgtg tgcaagtgca gggcaagtcc aagcgcgaga agaaagatcg ggtgttcacc    1500

gacaagacca gcgccaccgt gatctgcaga aagaacgcca gcatcagcgt gcgcgctcag    1560

gataggtact acagcagctc ttggagcgag tgggcctctg ttccttgttc tggcggcgga    1620

ggaagcggag gcggaggatc tggtggtggt ggaagtagaa acctgccagt ggctacccct    1680

gatccgggca tgtttccttg tctgcaccac agccagaacc tgctgagagc cgtgtccaat    1740

atgctgcaga aggcccggca gacccttgag ttctaccctt gcaccagcga ggaaatcgac    1800

cacgaggaca tcaccaagga taagaccagc accgtggaag cctgcctgcc tctggaactg    1860

accaagaacg agtcctgcct gaacagccgg gaaaccagct tcatcaccaa tggcagctgt    1920

ctggccagca gaaagacctc cttcatgatg gccctgtgcc tgagcagcat ctacgaggac    1980

ctgaagatgt atcaggtcga gttcaagacc atgaacgcca agctgctgat ggaccccaag    2040

agacagattt tcctcgacca gaacatgctg gccgtgatcg atgaactgat gcaggccctg    2100

aacttcaaca gcgagacagt gccccagaag tcctctctgg aagaacccga cttctacaag    2160

accaagatca agctgtgcat cctgctgcac gccttcagaa tcagggccgt gaccatcgac    2220

agagtgatga gctatctgaa cgccagctga aagcttggta cccaaacaaa caaaggcgcg    2280

tcctggattc gtggtaaaac ataccagatt tcgatctgga gaggtgaaga atacgaccac    2340

ctactacatc cagctgatga gtcccaaata ggacgaaacg cgctcaaaca aacaaaagat    2400

ctcttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca    2460

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct    2520

taacgcggcc gcacgtgcgg accgagcggc cgcaggaacc cctagtgatg gagttggcca    2580

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc    2640

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg cagg          2694


<210> 65
<211> 2694
<212> DNA
<213> Artificial Sequence


<220> 
<223> > AAV.LP1-hIL-12-3’-riboswitch: signalpeptide, IL12
      p40-(G4S)3-p35; carrying the 11nt deletion in the left ITR, and
      the 4nt deletion in the right ITR

<400> 65
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg      60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcagc     120

tgcctgcagg gcggccgcac gcgttcgacc ccctaaaatg ggcaaacatt gcaagcaaac     180

agcaaacaca cagccctccc tgcctgctga ccttggagct ggggcagagg tcagagacct     240

ctctgggccc atgccacctc caacatccac tcgacccctt ggaatttcgg tggagaggag     300

cagaggttgt cctggcgtgg tttaggtagt gtgagagggg aatgactcct ttcggtaagt     360

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     420

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     480

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     540

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt gaatccggac     600

tctaagagaa ttccccggac cggtggatcc gccaccatgg gctggtcctg catcattctg     660

tttctggtgg ccacagccac cggcgtgcac tctatttggg agctgaagaa agacgtgtac     720

gtggtcgagc tggactggta tcctgatgct cccggcgaaa tggtggtgct gacctgtgat     780

acacccgaag aggacggcat cacatggaca ctggatcagt ctagcgaggt gctcggcagc     840

ggcaagacac tgaccatcca agtgaaagag tttggcgacg ccggccagta cacatgtcac     900

aaaggcggag aggtgctgag ccattctctg ctgctgctcc acaagaaaga ggatggcatt     960

tggagcaccg acatcctgaa ggaccagaaa gagcccaaga acaagacctt cctgagatgc    1020

gaggccaaga actacagcgg cagattcacc tgttggtggc tgaccaccat cagcaccgat    1080

ctgaccttca gcgtgaagtc cagcagaggc agctctgatc ctcaaggcgt tacatgtggc    1140

gccgctacac tgtctgccga aagagtgcgg ggcgacaaca aagagtacga gtacagcgtc    1200

gagtgccaag aggattctgc ctgtcctgcc gccgaggaat ctctgcctat cgaagtgatg    1260

gtggacgccg tgcacaagct gaagtacgag aactacacca gcagcttttt catccgggac    1320

atcatcaagc ccgatcctcc aaagaacctg cagctgaagc ccctgaagaa cagcagacag    1380

gtggaagtgt cttgggagta ccccgacaca tggtctaccc ctcacagcta cttcagcctg    1440

accttctgtg tgcaagtgca gggcaagtcc aagcgcgaga agaaagatcg ggtgttcacc    1500

gacaagacca gcgccaccgt gatctgcaga aagaacgcca gcatcagcgt gcgcgctcag    1560

gataggtact acagcagctc ttggagcgag tgggcctctg ttccttgttc tggcggcgga    1620

ggaagcggag gcggaggatc tggtggtggt ggaagtagaa acctgccagt ggctacccct    1680

gatccgggca tgtttccttg tctgcaccac agccagaacc tgctgagagc cgtgtccaat    1740

atgctgcaga aggcccggca gacccttgag ttctaccctt gcaccagcga ggaaatcgac    1800

cacgaggaca tcaccaagga taagaccagc accgtggaag cctgcctgcc tctggaactg    1860

accaagaacg agtcctgcct gaacagccgg gaaaccagct tcatcaccaa tggcagctgt    1920

ctggccagca gaaagacctc cttcatgatg gccctgtgcc tgagcagcat ctacgaggac    1980

ctgaagatgt atcaggtcga gttcaagacc atgaacgcca agctgctgat ggaccccaag    2040

agacagattt tcctcgacca gaacatgctg gccgtgatcg atgaactgat gcaggccctg    2100

aacttcaaca gcgagacagt gccccagaag tcctctctgg aagaacccga cttctacaag    2160

accaagatca agctgtgcat cctgctgcac gccttcagaa tcagggccgt gaccatcgac    2220

agagtgatga gctatctgaa cgccagctga aagcttggta cccaaacaaa caaaggcgcg    2280

tcctggattc gtggtaaaac ataccagatt tcgatctgga gaggtgaaga atacgaccac    2340

ctactacatc cagctgatga gtcccaaata ggacgaaacg cgctcaaaca aacaaaagat    2400

ctcttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca    2460

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct    2520

taacgcggcc gcacgtgcgg accgagcggc cgcaggaacc cctagtgatg gagttggcca    2580

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc    2640

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg cagg          2694


<210> 66
<211> 2694
<212> DNA
<213> Artificial Sequence


<220> 
<223> > AAV. LP1-hIL-12-3’riboswitch; signalpeptide, IL12 p35(G4S)3p40;
      carrying the 11nt and 4nt deletion in the left ITR, and the 4nt
      deletion in the right ITR

<400> 66
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg      60

ccgggcgacc aaaggtcgcc cgacgcccgg gcggcctcag tgagcgagcg agcgcgcagc     120

tgcctgcagg gcggccgcac gcgttcgacc ccctaaaatg ggcaaacatt gcaagcaaac     180

agcaaacaca cagccctccc tgcctgctga ccttggagct ggggcagagg tcagagacct     240

ctctgggccc atgccacctc caacatccac tcgacccctt ggaatttcgg tggagaggag     300

cagaggttgt cctggcgtgg tttaggtagt gtgagagggg aatgactcct ttcggtaagt     360

gcagtggaag ctgtacactg cccaggcaaa gcgtccgggc agcgtaggcg ggcgactcag     420

atcccagcca gtggacttag cccctgtttg ctcctccgat aactggggtg accttggtta     480

atattcacca gcagcctccc ccgttgcccc tctggatcca ctgcttaaat acggacgagg     540

acagggccct gtctcctcag cttcaggcac caccactgac ctgggacagt gaatccggac     600

tctaagagaa ttccccggac cggtggatcc gccaccatgg gctggtcctg catcattctg     660

tttctggtgg ccacagccac cggcgtgcac tctagaaacc tgccagtggc tacccctgat     720

ccgggcatgt ttccttgtct gcaccacagc cagaacctgc tgagagccgt gtccaatatg     780

ctgcagaagg cccggcagac ccttgagttc tacccttgca ccagcgagga aatcgaccac     840

gaggacatca ccaaggataa gaccagcacc gtggaagcct gcctgcctct ggaactgacc     900

aagaacgagt cctgcctgaa cagccgggaa accagcttca tcaccaatgg cagctgtctg     960

gccagcagaa agacctcctt catgatggcc ctgtgcctga gcagcatcta cgaggacctg    1020

aagatgtatc aggtcgagtt caagaccatg aacgccaagc tgctgatgga ccccaagaga    1080

cagattttcc tcgaccagaa catgctggcc gtgatcgatg aactgatgca ggccctgaac    1140

ttcaacagcg agacagtgcc ccagaagtcc tctctggaag aacccgactt ctacaagacc    1200

aagatcaagc tgtgcatcct gctgcacgcc ttcagaatca gggccgtgac catcgacaga    1260

gtgatgagct atctgaacgc cagcggcggc ggaggaagcg gaggcggagg atctggtggt    1320

ggtggaagta tttgggagct gaagaaagac gtgtacgtgg tcgagctgga ctggtatcct    1380

gatgctcccg gcgaaatggt ggtgctgacc tgtgatacac ccgaagagga cggcatcaca    1440

tggacactgg atcagtctag cgaggtgctc ggcagcggca agacactgac catccaagtg    1500

aaagagtttg gcgacgccgg ccagtacaca tgtcacaaag gcggagaggt gctgagccat    1560

tctctgctgc tgctccacaa gaaagaggat ggcatttgga gcaccgacat cctgaaggac    1620

cagaaagagc ccaagaacaa gaccttcctg agatgcgagg ccaagaacta cagcggcaga    1680

ttcacctgtt ggtggctgac caccatcagc accgatctga ccttcagcgt gaagtccagc    1740

agaggcagct ctgatcctca aggcgttaca tgtggcgccg ctacactgtc tgccgaaaga    1800

gtgcggggcg acaacaaaga gtacgagtac agcgtcgagt gccaagagga ttctgcctgt    1860

cctgccgccg aggaatctct gcctatcgaa gtgatggtgg acgccgtgca caagctgaag    1920

tacgagaact acaccagcag ctttttcatc cgggacatca tcaagcccga tcctccaaag    1980

aacctgcagc tgaagcccct gaagaacagc agacaggtgg aagtgtcttg ggagtacccc    2040

gacacatggt ctacccctca cagctacttc agcctgacct tctgtgtgca agtgcagggc    2100

aagtccaagc gcgagaagaa agatcgggtg ttcaccgaca agaccagcgc caccgtgatc    2160

tgcagaaaga acgccagcat cagcgtgcgc gctcaggata ggtactacag cagctcttgg    2220

agcgagtggg cctctgttcc ttgttcttga aagcttggta cccaaacaaa caaaggcgcg    2280

tcctggattc gtggtaaaac ataccagatt tcgatctgga gaggtgaaga atacgaccac    2340

ctactacatc cagctgatga gtcccaaata ggacgaaacg cgctcaaaca aacaaaagat    2400

ctcttgttta ttgcagctta taatggttac aaataaagca atagcatcac aaatttcaca    2460

aataaagcat ttttttcact gcattctagt tgtggtttgt ccaaactcat caatgtatct    2520

taacgcggcc gcacgtgcgg accgagcggc cgcaggaacc cctagtgatg gagttggcca    2580

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc    2640

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cagctgcctg cagg          2694


<210> 67
<211> 428
<212> DNA
<213> Homo sapiens


<220> 
<223> > human CEA promoter

<400> 67
gccctggaga gcatggggag acccgggacc ctgctgggtt tctctgtcac aaaggaaaat      60

aatccccctg gtgtgacaga cccaaggaca gaacacagca gaggtcagca ctggggaaga     120

caggttgtcc tcccagggga tgggggtcca tccaccttgc cgaaaagatt tgtctgagga     180

actgaaaata gaagggaaaa aagaggaggg acaaaagagg cagaaatgag aggggagggg     240

acagaggaca cctgaataaa gaccacaccc atgacccacg tgatgctgag aagtactcct     300

gccctaggaa gagactcagg gcagagggag gaaggacagc agaccagaca gtcacagcag     360

ccttgacaaa acgttcctgg aactcaagct cttctccaca gaggaggaca gagcagacag     420

cagagacc                                                              428


<210> 68
<211> 770
<212> DNA
<213> Homo sapiens


<220> 
<223> > human Muc1 promoter

<400> 68
cctgcagggc ccactagtgt tcatcggagc ccaggtttac tcccttaagt ggaaatttct      60

tcccccactc cctccttggc tttctccaag gagggaaccc aggctactgg aaagtccggc     120

tggggcgggg actgtgggtt tcagggtaga actgcgtgtg gaacgggaca gggagcggtt     180

agaagggtgg ggctattccg ggaagtggtg gggggaggga gcccaaaact agcacctagt     240

ccactcatta tccagccctc ttatttctcg gccccgctct gcttcagtgg acccggggag     300

ggcggggaag tggagtggga gacctagggg tgggcttccc gaccttgctg tacaggacct     360

cgacctagct ggctttgttc cccatcccca cgttagttgt tgccctgagg ctaaaactag     420

agcccagggg ccccaagttc cagactgccc ctcccccctc ccccggagcc agggagtggt     480

tggtgaaagg gggaggccag ctggagaaca aacgggtagt cagggggttg agcgattaga     540

gcccttgtac cctacccagg aatggttggg gaggaggagg aagaggtagg aggtagggga     600

gggggcgggg ttttgtcacc tgtcacctgc tccggctgtg cctagggcgg gcgggcgggg     660

agtgggggga ccggtataaa gcggtaggcg cctgtgcccg ctccacctct caagcagcca     720

gcgcctgcct gaatctgttc tgccccctcc ccacccattt caccaccacc                770


<210> 69
<211> 276
<212> DNA
<213> Homo sapiens


<220> 
<223> > human AFP promoter

<400> 69
attctgtagt ttgaggagaa tatttgttat atttgcaaaa taaaataagt ttgcaagttt     60

tttttttctg ccccaaagag ctctgtgtcc ttgaacataa aatacaaata accgctatgc    120

tgttaattat tggcaaatgt cccattttca acctaaggaa ataccataaa gtaacagata    180

taccaacaaa aggttactag ttaacaggca ttgcctgaaa agagtataaa agaatttcag    240

catgattttc catattgtgc ttccaccact gccaat                              276


<210> 70
<211> 738
<212> PRT
<213> Adeno-associated virus - 8


<220> 
<223> GenBank: AAN03857.1 Capsid Protein adeno-associated Virus 8, AAV8
      VP1 sequence

<400> 70
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         
Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             
Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 
Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         
Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             
His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 
Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     
Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         
Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     
Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 
Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     
Asn Leu 
        

<210> 71
<211> 2217
<212> DNA
<213> Adeno-associated virus - 8


<220> 
<223> GenBank: AF513852.1 AAV8 VP1 Capsid CDS sequence

<400> 71
atggctgccg atggttatct tccagattgg ctcgaggaca acctctctga gggcattcgc      60

gagtggtggg cgctgaaacc tggagccccg aagcccaaag ccaaccagca aaagcaggac     120

gacggccggg gtctggtgct tcctggctac aagtacctcg gacccttcaa cggactcgac     180

aagggggagc ccgtcaacgc ggcggacgca gcggccctcg agcacgacaa ggcctacgac     240

cagcagctgc aggcgggtga caatccgtac ctgcggtata accacgccga cgccgagttt     300

caggagcgtc tgcaagaaga tacgtctttt gggggcaacc tcgggcgagc agtcttccag     360

gccaagaagc gggttctcga acctctcggt ctggttgagg aaggcgctaa gacggctcct     420

ggaaagaaga gaccggtaga gccatcaccc cagcgttctc cagactcctc tacgggcatc     480

ggcaagaaag gccaacagcc cgccagaaaa agactcaatt ttggtcagac tggcgactca     540

gagtcagttc cagaccctca acctctcgga gaacctccag cagcgccctc tggtgtggga     600

cctaatacaa tggctgcagg cggtggcgca ccaatggcag acaataacga aggcgccgac     660

ggagtgggta gttcctcggg aaattggcat tgcgattcca catggctggg cgacagagtc     720

atcaccacca gcacccgaac ctgggccctg cccacctaca acaaccacct ctacaagcaa     780

atctccaacg ggacatcggg aggagccacc aacgacaaca cctacttcgg ctacagcacc     840

ccctgggggt attttgactt taacagattc cactgccact tttcaccacg tgactggcag     900

cgactcatca acaacaactg gggattccgg cccaagagac tcagcttcaa gctcttcaac     960

atccaggtca aggaggtcac gcagaatgaa ggcaccaaga ccatcgccaa taacctcacc    1020

agcaccatcc aggtgtttac ggactcggag taccagctgc cgtacgttct cggctctgcc    1080

caccagggct gcctgcctcc gttcccggcg gacgtgttca tgattcccca gtacggctac    1140

ctaacactca acaacggtag tcaggccgtg ggacgctcct ccttctactg cctggaatac    1200

tttccttcgc agatgctgag aaccggcaac aacttccagt ttacttacac cttcgaggac    1260

gtgcctttcc acagcagcta cgcccacagc cagagcttgg accggctgat gaatcctctg    1320

attgaccagt acctgtacta cttgtctcgg actcaaacaa caggaggcac ggcaaatacg    1380

cagactctgg gcttcagcca aggtgggcct aatacaatgg ccaatcaggc aaagaactgg    1440

ctgccaggac cctgttaccg ccaacaacgc gtctcaacga caaccgggca aaacaacaat    1500

agcaactttg cctggactgc tgggaccaaa taccatctga atggaagaaa ttcattggct    1560

aatcctggca tcgctatggc aacacacaaa gacgacgagg agcgtttttt tcccagtaac    1620

gggatcctga tttttggcaa acaaaatgct gccagagaca atgcggatta cagcgatgtc    1680

atgctcacca gcgaggaaga aatcaaaacc actaaccctg tggctacaga ggaatacggt    1740

atcgtggcag ataacttgca gcagcaaaac acggctcctc aaattggaac tgtcaacagc    1800

cagggggcct tacccggtat ggtctggcag aaccgggacg tgtacctgca gggtcccatc    1860

tgggccaaga ttcctcacac ggacggcaac ttccacccgt ctccgctgat gggcggcttt    1920

ggcctgaaac atcctccgcc tcagatcctg atcaagaaca cgcctgtacc tgcggatcct    1980

ccgaccacct tcaaccagtc aaagctgaac tctttcatca cgcaatacag caccggacag    2040

gtcagcgtgg aaattgaatg ggagctgcag aaggaaaaca gcaagcgctg gaaccccgag    2100

atccagtaca cctccaacta ctacaaatct acaagtgtgg actttgctgt taatacagaa    2160

ggcgtgtact ctgaaccccg ccccattggc acccgttacc tcacccgtaa tctgtaa       2217


<210> 72
<211> 463
<212> DNA
<213> Homo sapiens


<220> 
<223> >LP1 promotor without SV40 intron

<400> 72
tcgaccccct aaaatgggca aacattgcaa gcaaacagca aacacacagc cctccctgcc      60

tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc cacctccaac     120

atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg gcgtggttta     180

ggtagtgtga gaggggaatg actcctttcg gtaagtgcag tggaagctgt acactgccca     240

ggcaaagcgt ccgggcagcg taggcgggcg actcagatcc cagccagtgg acttagcccc     300

tgtttgctcc tccgataact ggggtgacct tggttaatat tcaccagcag cctcccccgt     360

tgcccctctg gatccactgc ttaaatacgg acgaggacag ggccctgtct cctcagcttc     420

aggcaccacc actgacctgg gacagtgaat ccggactcta aga                       463


<210> 73
<211> 2409
<212> DNA
<213> Artificial Sequence


<220> 
<223> > LP1-hIL-12-3’-riboswitch: signalpeptide, IL12 p40-(G4S)3-p35;
      expression cassette

<400> 73
tcgaccccct aaaatgggca aacattgcaa gcaaacagca aacacacagc cctccctgcc      60

tgctgacctt ggagctgggg cagaggtcag agacctctct gggcccatgc cacctccaac     120

atccactcga ccccttggaa tttcggtgga gaggagcaga ggttgtcctg gcgtggttta     180

ggtagtgtga gaggggaatg actcctttcg gtaagtgcag tggaagctgt acactgccca     240

ggcaaagcgt ccgggcagcg taggcgggcg actcagatcc cagccagtgg acttagcccc     300

tgtttgctcc tccgataact ggggtgacct tggttaatat tcaccagcag cctcccccgt     360

tgcccctctg gatccactgc ttaaatacgg acgaggacag ggccctgtct cctcagcttc     420

aggcaccacc actgacctgg gacagtgaat ccggactcta agagaattcc ccggaccggt     480

ggatccgcca ccatgggctg gtcctgcatc attctgtttc tggtggccac agccaccggc     540

gtgcactcta tttgggagct gaagaaagac gtgtacgtgg tcgagctgga ctggtatcct     600

gatgctcccg gcgaaatggt ggtgctgacc tgtgatacac ccgaagagga cggcatcaca     660

tggacactgg atcagtctag cgaggtgctc ggcagcggca agacactgac catccaagtg     720

aaagagtttg gcgacgccgg ccagtacaca tgtcacaaag gcggagaggt gctgagccat     780

tctctgctgc tgctccacaa gaaagaggat ggcatttgga gcaccgacat cctgaaggac     840

cagaaagagc ccaagaacaa gaccttcctg agatgcgagg ccaagaacta cagcggcaga     900

ttcacctgtt ggtggctgac caccatcagc accgatctga ccttcagcgt gaagtccagc     960

agaggcagct ctgatcctca aggcgttaca tgtggcgccg ctacactgtc tgccgaaaga    1020

gtgcggggcg acaacaaaga gtacgagtac agcgtcgagt gccaagagga ttctgcctgt    1080

cctgccgccg aggaatctct gcctatcgaa gtgatggtgg acgccgtgca caagctgaag    1140

tacgagaact acaccagcag ctttttcatc cgggacatca tcaagcccga tcctccaaag    1200

aacctgcagc tgaagcccct gaagaacagc agacaggtgg aagtgtcttg ggagtacccc    1260

gacacatggt ctacccctca cagctacttc agcctgacct tctgtgtgca agtgcagggc    1320

aagtccaagc gcgagaagaa agatcgggtg ttcaccgaca agaccagcgc caccgtgatc    1380

tgcagaaaga acgccagcat cagcgtgcgc gctcaggata ggtactacag cagctcttgg    1440

agcgagtggg cctctgttcc ttgttctggc ggcggaggaa gcggaggcgg aggatctggt    1500

ggtggtggaa gtagaaacct gccagtggct acccctgatc cgggcatgtt tccttgtctg    1560

caccacagcc agaacctgct gagagccgtg tccaatatgc tgcagaaggc ccggcagacc    1620

cttgagttct acccttgcac cagcgaggaa atcgaccacg aggacatcac caaggataag    1680

accagcaccg tggaagcctg cctgcctctg gaactgacca agaacgagtc ctgcctgaac    1740

agccgggaaa ccagcttcat caccaatggc agctgtctgg ccagcagaaa gacctccttc    1800

atgatggccc tgtgcctgag cagcatctac gaggacctga agatgtatca ggtcgagttc    1860

aagaccatga acgccaagct gctgatggac cccaagagac agattttcct cgaccagaac    1920

atgctggccg tgatcgatga actgatgcag gccctgaact tcaacagcga gacagtgccc    1980

cagaagtcct ctctggaaga acccgacttc tacaagacca agatcaagct gtgcatcctg    2040

ctgcacgcct tcagaatcag ggccgtgacc atcgacagag tgatgagcta tctgaacgcc    2100

agctgaaagc ttggtaccca aacaaacaaa ggcgcgtcct ggattcgtgg taaaacatac    2160

cagatttcga tctggagagg tgaagaatac gaccacctac tacatccagc tgatgagtcc    2220

caaataggac gaaacgcgct caaacaaaca aaagatctct tgtttattgc agcttataat    2280

ggttacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat    2340

tctagttgtg gtttgtccaa actcatcaat gtatcttaac gcggccgcac gtgcggaccg    2400

agcggccgc                                                            2409


<210> 74
<211> 2607
<212> DNA
<213> Artificial Sequence


<220> 
<223> > LP1_SV40-hIL-12-3’-riboswitch: signalpeptide, IL12
      p40-(G4S)3-p35; expression cassette

<400> 74
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc      60

tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac ctccaacatc     120

cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg tggtttaggt     180

agtgtgagag ggtccgggtt caaaaccact tgctgggtgg ggagtcgtca gtaagtggct     240

atgccccgac cccgaagcct gtttccccat ctgtacaatg gaaatgataa agacgcccat     300

ctgataggga atgactcctt tcggtaagtg cagtggaagc tgtacactgc ccaggcaaag     360

cgtccgggca gcgtaggcgg gcgactcaga tcccagccag tggacttagc ccctgtttgc     420

tcctccgata actggggtga ccttggttaa tattcaccag cagcctcccc cgttgcccct     480

ctggatccac tgcttaaata cggacgagga cagggccctg tctcctcagc ttcaggcacc     540

accactgacc tgggacagtg aatccggact ctaaggtaaa tataaaattt ttaagtgtat     600

aatgtgttaa actactgatt ctaattgttt ctctatttta gattccaacc tttggaactg     660

agaattcccc ggaccggtgg atccgccacc atgggctggt cctgcatcat tctgtttctg     720

gtggccacag ccaccggcgt gcactctatt tgggagctga agaaagacgt gtacgtggtc     780

gagctggact ggtatcctga tgctcccggc gaaatggtgg tgctgacctg tgatacaccc     840

gaagaggacg gcatcacatg gacactggat cagtctagcg aggtgctcgg cagcggcaag     900

acactgacca tccaagtgaa agagtttggc gacgccggcc agtacacatg tcacaaaggc     960

ggagaggtgc tgagccattc tctgctgctg ctccacaaga aagaggatgg catttggagc    1020

accgacatcc tgaaggacca gaaagagccc aagaacaaga ccttcctgag atgcgaggcc    1080

aagaactaca gcggcagatt cacctgttgg tggctgacca ccatcagcac cgatctgacc    1140

ttcagcgtga agtccagcag aggcagctct gatcctcaag gcgttacatg tggcgccgct    1200

acactgtctg ccgaaagagt gcggggcgac aacaaagagt acgagtacag cgtcgagtgc    1260

caagaggatt ctgcctgtcc tgccgccgag gaatctctgc ctatcgaagt gatggtggac    1320

gccgtgcaca agctgaagta cgagaactac accagcagct ttttcatccg ggacatcatc    1380

aagcccgatc ctccaaagaa cctgcagctg aagcccctga agaacagcag acaggtggaa    1440

gtgtcttggg agtaccccga cacatggtct acccctcaca gctacttcag cctgaccttc    1500

tgtgtgcaag tgcagggcaa gtccaagcgc gagaagaaag atcgggtgtt caccgacaag    1560

accagcgcca ccgtgatctg cagaaagaac gccagcatca gcgtgcgcgc tcaggatagg    1620

tactacagca gctcttggag cgagtgggcc tctgttcctt gttctggcgg cggaggaagc    1680

ggaggcggag gatctggtgg tggtggaagt agaaacctgc cagtggctac ccctgatccg    1740

ggcatgtttc cttgtctgca ccacagccag aacctgctga gagccgtgtc caatatgctg    1800

cagaaggccc ggcagaccct tgagttctac ccttgcacca gcgaggaaat cgaccacgag    1860

gacatcacca aggataagac cagcaccgtg gaagcctgcc tgcctctgga actgaccaag    1920

aacgagtcct gcctgaacag ccgggaaacc agcttcatca ccaatggcag ctgtctggcc    1980

agcagaaaga cctccttcat gatggccctg tgcctgagca gcatctacga ggacctgaag    2040

atgtatcagg tcgagttcaa gaccatgaac gccaagctgc tgatggaccc caagagacag    2100

attttcctcg accagaacat gctggccgtg atcgatgaac tgatgcaggc cctgaacttc    2160

aacagcgaga cagtgcccca gaagtcctct ctggaagaac ccgacttcta caagaccaag    2220

atcaagctgt gcatcctgct gcacgccttc agaatcaggg ccgtgaccat cgacagagtg    2280

atgagctatc tgaacgccag ctgaaagctt ggtacccaaa caaacaaagg cgcgtcctgg    2340

attcgtggta aaacatacca gatttcgatc tggagaggtg aagaatacga ccacctacta    2400

catccagctg atgagtccca aataggacga aacgcgctca aacaaacaaa agatctcttg    2460

tttattgcag cttataatgg ttacaaataa agcaatagca tcacaaattt cacaaataaa    2520

gcattttttt cactgcattc tagttgtggt ttgtccaaac tcatcaatgt atcttaacgc    2580

ggccgcacgt gcggaccgag cggccgc                                        2607


<210> 75
<211> 537
<212> PRT
<213> Artificial Sequence


<220> 
<223> >single chain human IL12 - with SP according to SEQ ID NO: 52,
      long linker (Seq ID No. 75)

<400> 75
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      
Val His Ser Ile Trp Glu Leu Lys Lys Asp Val Tyr Val Val Glu Leu 
            20                  25                  30          
Asp Trp Tyr Pro Asp Ala Pro Gly Glu Met Val Val Leu Thr Cys Asp 
        35                  40                  45              
Thr Pro Glu Glu Asp Gly Ile Thr Trp Thr Leu Asp Gln Ser Ser Glu 
    50                  55                  60                  
Val Leu Gly Ser Gly Lys Thr Leu Thr Ile Gln Val Lys Glu Phe Gly 
65                  70                  75                  80  
Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Val Leu Ser His 
                85                  90                  95      
Ser Leu Leu Leu Leu His Lys Lys Glu Asp Gly Ile Trp Ser Thr Asp 
            100                 105                 110         
Ile Leu Lys Asp Gln Lys Glu Pro Lys Asn Lys Thr Phe Leu Arg Cys 
        115                 120                 125             
Glu Ala Lys Asn Tyr Ser Gly Arg Phe Thr Cys Trp Trp Leu Thr Thr 
    130                 135                 140                 
Ile Ser Thr Asp Leu Thr Phe Ser Val Lys Ser Ser Arg Gly Ser Ser 
145                 150                 155                 160 
Asp Pro Gln Gly Val Thr Cys Gly Ala Ala Thr Leu Ser Ala Glu Arg 
                165                 170                 175     
Val Arg Gly Asp Asn Lys Glu Tyr Glu Tyr Ser Val Glu Cys Gln Glu 
            180                 185                 190         
Asp Ser Ala Cys Pro Ala Ala Glu Glu Ser Leu Pro Ile Glu Val Met 
        195                 200                 205             
Val Asp Ala Val His Lys Leu Lys Tyr Glu Asn Tyr Thr Ser Ser Phe 
    210                 215                 220                 
Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Leu 
225                 230                 235                 240 
Lys Pro Leu Lys Asn Ser Arg Gln Val Glu Val Ser Trp Glu Tyr Pro 
                245                 250                 255     
Asp Thr Trp Ser Thr Pro His Ser Tyr Phe Ser Leu Thr Phe Cys Val 
            260                 265                 270         
Gln Val Gln Gly Lys Ser Lys Arg Glu Lys Lys Asp Arg Val Phe Thr 
        275                 280                 285             
Asp Lys Thr Ser Ala Thr Val Ile Cys Arg Lys Asn Ala Ser Ile Ser 
    290                 295                 300                 
Val Arg Ala Gln Asp Arg Tyr Tyr Ser Ser Ser Trp Ser Glu Trp Ala 
305                 310                 315                 320 
Ser Val Pro Cys Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                325                 330                 335     
Gly Gly Gly Ser Arg Asn Leu Pro Val Ala Thr Pro Asp Pro Gly Met 
            340                 345                 350         
Phe Pro Cys Leu His His Ser Gln Asn Leu Leu Arg Ala Val Ser Asn 
        355                 360                 365             
Met Leu Gln Lys Ala Arg Gln Thr Leu Glu Phe Tyr Pro Cys Thr Ser 
    370                 375                 380                 
Glu Glu Ile Asp His Glu Asp Ile Thr Lys Asp Lys Thr Ser Thr Val 
385                 390                 395                 400 
Glu Ala Cys Leu Pro Leu Glu Leu Thr Lys Asn Glu Ser Cys Leu Asn 
                405                 410                 415     
Ser Arg Glu Thr Ser Phe Ile Thr Asn Gly Ser Cys Leu Ala Ser Arg 
            420                 425                 430         
Lys Thr Ser Phe Met Met Ala Leu Cys Leu Ser Ser Ile Tyr Glu Asp 
        435                 440                 445             
Leu Lys Met Tyr Gln Val Glu Phe Lys Thr Met Asn Ala Lys Leu Leu 
    450                 455                 460                 
Met Asp Pro Lys Arg Gln Ile Phe Leu Asp Gln Asn Met Leu Ala Val 
465                 470                 475                 480 
Ile Asp Glu Leu Met Gln Ala Leu Asn Phe Asn Ser Glu Thr Val Pro 
                485                 490                 495     
Gln Lys Ser Ser Leu Glu Glu Pro Asp Phe Tyr Lys Thr Lys Ile Lys 
            500                 505                 510         
Leu Cys Ile Leu Leu His Ala Phe Arg Ile Arg Ala Val Thr Ile Asp 
        515                 520                 525             
Arg Val Met Ser Tyr Leu Asn Ala Ser 
    530                 535         

