                         SEQUENCE LISTING

<110>  ϺƼѧ
 
<120>  һֺԼСⷽӦ

<130>  P21406127C

<150>  202010426283.1
<151>  2020-05-19

<160>  81    

<170>  PatentIn version 3.5

<210>  1
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-O-Cr1

<400>  1
uaauuucuac uaaguguaga uuacagguua gcuaacgagu gugc                        44


<210>  2
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-O-Cr2

<400>  2
uaauuucuac uaaguguaga uucaagcugu uacagccaau guaa                        44


<210>  3
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  SARS-O-Cr3

<400>  3
uaauuucuac uaaguguaga uaacugaugg uaauaagaua gcug                        44


<210>  4
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MC-E-crRNA1

<400>  4
uaauuucuac uaaguguaga ugacauaugg aaaacgaacu augu                        44


<210>  5
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MC-E-crRNA2

<400>  5
uaauuucuac uaaguguaga uuccaagaac gaauaggguu guuc                        44


<210>  6
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MC-E-crRNA3

<400>  6
uaauuucuac uaaguguaga ucuaugaaca acccuauucg uucu                        44


<210>  7
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MC-E-crRNA4

<400>  7
uaauuucuac uaaguguaga ucauaugucc aaagagagac uaau                        44


<210>  8
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MC-O-Cr1

<400>  8
uaauuucuac uaaguguaga uacuuaugca aacauagucu acga                        44


<210>  9
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MC-O-Cr2

<400>  9
uaauuucuac uaaguguaga ugucagcgcu gauugcaguu gcaa                        44


<210>  10
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  MC-O-Cr3

<400>  10
uaauuucuac uaaguguaga ucaacugcaa ucagcgcuga cgaa                        44


<210>  11
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-Orf1ab

<400>  11
taatacgact cactataggt ctagaaataa ttttgtttaa ctttaagaag gagatatacc       60

atgctaacat gcttaggata atggcctctc ttgttcttgc tcgcaaacat aacacttgct      120

gtaacttatc acaccgtttc tacaggttag ctaacgagtg tgcgcaagta ttaagtgaga      180

tggtcatgtg tggcggctca ctatatgtta aaccaggtgg aacatcatcc ggtgatgcta      240

caactgctta tgctaatagt gtctttaaca tttgtcaagc tgttacagcc aatgtaaatg      300

cacttctttc aactgatggt aataagatag ctgacaagta tgtccgcaat ctacaacaca      360

ggctctatga gtgtctctat agaaataggg atgttgatca tgaattcgtg gatgagtttt      420

acgcttacct gtttttttga attc                                             444


<210>  12
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS-upE

<400>  12
taatacgact cactataggt ctagaaataa ttttgtttaa ctttaagaag gagatatacc       60

atgctgtttt cgtgcctgca acgcgcgatt cagttcctct tcacataatc gccccgagct      120

cgcttatcgt ttaagcagct ctgcgctact atgggtcccg tgtagaggct aatccattag      180

tctctctttg gacatatgga aaacgaacta tgttaccctt tgtccaagaa cgaatagggt      240

tgttcatagt aaactttttc atttttaccg tagtatgtgc tataacactc ttggtgtgta      300

tggctttcct tacggctact agattatgtg tgtttttttg aattc                      345


<210>  13
<211>  449
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS-Orf1a

<400>  13
taatacgact cactataggg agatctagaa ataattttgt ttaactttaa gaaggagata       60

taccatgact attcccacac agttgttccc actcttattt gtgactatgg ccttcgttat      120

gttgttggtt aaacacaaac acaccttttt gacacttttc ttgttgcctg tggctatttg      180

tttgacttat gcaaacatag tctacgagcc cactactccc atttcgtcag cgctgattgc      240

agttgcaaat tggcttgccc ccactaatgc ttatatgcgc actacacata ctgatattgg      300

tgtctacatt agtatgtcac ttgtattagt cattgtagtg aagagattgt acaacccatc      360

actttctaac tttgcgttag cattgtgcag tggtgtaatg tggttgtaca cttatagcat      420

tggagaagcc tcaagctttt tttgaattc                                        449


<210>  14
<211>  3924
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AsCpf1

<400>  14
atgactcagt tcgaggggtt caccaatttg taccaggtct ctaagacact tcgctttgag       60

cttatccctc agggcaagac gctgaagcat atccaggagc aaggatttat cgaggaggac      120

aaggcacgta atgaccacta taaagagctg aaaccgatca ttgatcgcat ttacaagacc      180

tatgcagatc agtgtctgca gcttgtgcaa ttagattggg aaaatctgag cgccgcaatc      240

gactcctatc gtaaagagaa gactgaagaa acacgtaatg cattaattga agaacaggcc      300

acgtatcgca atgctatcca cgattatttt attgggcgca ccgacaattt aactgatgcc      360

atcaataagc gtcacgcaga gatctacaag ggacttttta aagccgaatt atttaatggc      420

aaggttttaa aacagcttgg tactgtaaca acaacagagc acgagaatgc ccttctgcgc      480

tcgttcgata agtttaccac gtacttctcg ggcttttacg aaaaccgcaa aaacgtgttc      540

tcggcggagg acatctctac agctatccca caccgtattg tacaagataa cttccccaaa      600

tttaaggaga attgtcacat tttcacgcgt ttgattactg cggtaccgtc tttacgtgag      660

catttcgaaa acgttaagaa ggcaattggc atttttgtca gcacgtctat tgaagaagtg      720

ttctcgtttc ccttctacaa tcagctgttg actcaaacgc agatcgactt atataaccag      780

ctgttgggtg gcatctcacg cgaggcaggc acagaaaaaa ttaaaggcct gaacgaggtc      840

ttgaatttgg ctatccagaa gaacgatgag accgcgcaca tcattgcttc cttacctcat      900

cgctttattc cgttgtttaa acaaattctt agtgatcgta atactttatc cttcatctta      960

gaggaattta aatccgacga ggaggttatt cagtccttct gcaaatataa aactctgtta     1020

cgcaacgaga acgtgcttga aaccgcggag gctttattca acgagctgaa ctcgattgac     1080

ttgacacata ttttcatctc acacaagaaa ctggaaacga tttcgtcagc cctttgcgac     1140

cactgggata ctctgcgtaa cgcattatat gaacgtcgca tttccgaatt gacaggaaaa     1200

atcactaaga gcgcaaagga gaaggtacag cgttcgctga aacatgaaga catcaacctt     1260

caggagatta tctctgcggc gggcaaagaa cttagtgaag catttaagca aaaaaccagt     1320

gagatcctta gccatgcgca cgctgctctt gaccaaccac ttccgacaac gctgaaaaaa     1380

caggaggaaa aggagattct gaagagccag ctggattctt tacttggact ttatcatttg     1440

ttggattggt ttgccgtgga cgaaagtaac gaagtagatc ccgaattttc ggcgcgcctt     1500

accggcatca agttggaaat ggaaccctca ctgtcgttct acaataaagc ccgcaactac     1560

gccactaaaa agccctattc ggtagaaaag tttaagttga actttcagat gccaactctt     1620

gcttcaggat gggatgtgaa caaagaaaag aataacggag ctattttgtt cgttaagaac     1680

ggtctgtatt atcttggaat catgccgaaa cagaagggac gttacaaagc gctttcgttc     1740

gaaccaacag aaaagacctc cgaggggttc gataagatgt attacgacta ttttccggac     1800

gcagcaaaaa tgatcccgaa gtgctcaacg cagctgaaag ctgtgactgc gcattttcaa     1860

actcacacga cccccatttt gttatccaat aatttcatcg aacctttgga aattacgaag     1920

gagatctatg acttaaacaa tcctgaaaaa gagccgaaaa aatttcaaac cgcgtacgcc     1980

aagaaaaccg gggaccaaaa agggtaccgc gaagctcttt gcaaatggat cgacttcact     2040

cgtgattttc tttctaagta tacgaaaact acgtcgattg acttatcgag tttacgccca     2100

tcctctcaat acaaggatct gggggaatat tatgccgaac tgaatcctct tttatatcac     2160

atcagcttcc aacgcatcgc cgaaaaagag attatggacg cggtcgagac gggaaagctt     2220

tacttatttc aaatctataa taaagatttc gccaaaggtc atcacgggaa acccaatctg     2280

cacacccttt attggacagg tctgttctct cccgaaaact tagcgaaaac atccattaag     2340

cttaacgggc aggcagagtt gttctatcgt cccaaatccc gtatgaagcg catggcacac     2400

cgtcttggag aaaaaatgct taacaaaaag cttaaagacc aaaaaactcc gatccctgat     2460

accctttacc aagagttata tgattatgtc aatcatcgct tatcacatga cttgtccgac     2520

gaggcacgcg cacttttacc aaacgtcatc acgaaggaag tcagtcacga aatcattaag     2580

gatcgtcgtt tcacatccga taaatttttt tttcacgtac caattacttt gaactatcag     2640

gctgccaata gtccgagcaa gttcaatcaa cgtgtaaacg cgtacttaaa ggagcacccc     2700

gaaaccccca ttatcgggat cgaccgcggc gaacgcaatc ttatctatat cacggttatc     2760

gattctactg gaaaaatttt agagcagcgt tccctgaaca ccattcaaca gtttgattat     2820

cagaagaaac ttgacaatcg cgaaaaagaa cgtgttgcgg cgcgtcaagc atggagcgtt     2880

gttggtacaa tcaaagacct taaacaaggt tacttatcgc aggtcatcca cgagatcgtt     2940

gacctgatga tccactacca agctgtcgtc gtacttgaaa atcttaattt cggcttcaag     3000

tccaaacgta caggaattgc ggaaaaggct gtataccaac aattcgaaaa aatgcttatc     3060

gataagctta actgccttgt gttgaaagat taccctgcgg aaaaagtcgg aggtgtatta     3120

aacccatatc aattgaccga tcaattcact tcatttgcca aaatgggcac gcagtcaggg     3180

tttttgttct atgtaccagc tccatatacc tctaagattg atccgttaac gggctttgtt     3240

gatcctttcg tctggaagac catcaaaaac catgaaagcc gcaaacactt ccttgagggc     3300

tttgactttc ttcactacga tgtaaagacc ggagatttca tcttacactt caaaatgaac     3360

cgcaatctgt ctttccaacg tggtttacct ggatttatgc ctgcgtggga catcgtattc     3420

gagaaaaatg aaactcagtt tgatgcaaaa ggcacgccgt ttatcgccgg aaagcgcatt     3480

gtaccagtta tcgagaacca ccgtttcaca gggcgttacc gcgacctgta ccccgcgaac     3540

gaattgatcg cgctgttaga agaaaaggga atcgttttcc gtgacgggtc caacatctta     3600

cccaagttac ttgaaaacga cgacagtcac gcaatcgaca caatggttgc tttaatccgc     3660

tccgttctgc aaatgcgtaa cagcaacgct gcgactggtg aggactacat taatagcccg     3720

gtccgcgacc ttaacggcgt atgtttcgac tcccgtttcc agaatcctga gtggcccatg     3780

gacgcagacg caaatggggc ctaccatatt gcgctgaaag gtcaattact tctgaatcac     3840

ttgaaggaat ctaaggacct taaactgcag aatgggatct caaaccaaga ctggttagcg     3900

tacattcagg aattacgtaa ctag                                            3924


<210>  15
<211>  3729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BbCpf1

<400>  15
atgaaaaagt ttaccaatct gtatccggtt caaaaaacac ttcgttttga acttatcccg       60

caaggcaata cctctaaaca tctttgcaaa attattcagg aggacgagca gatcgcagag      120

gactcgcaag aagtgaaaaa attattagac cgttatcata aagagttcat cgcaattgct      180

ttaagcagct tccctacgtc tcctttagcg aaagaaatta tcccgaaact gaaagagttt      240

gctcaaatcc gtgctacagg ggatgcaaag cagatttcaa caattcaaga tgaacttcgt      300

gagctggtgg ttaaaggttt caagggggag ggggagcaag aacgtcgtta caaaatcttg      360

atcggagcaa aggggaatcc aaacgccgat gaactgttta acactgagtt gattaacttt      420

cttaaagatc cggctgagca agccctggta aaaaagtttc agaaacatac tggttatttc      480

ttgggattta acgaaaatcg caagaacatg tactcggcga aggctcagag tacggctatt      540

gcgtatcgct taattcatga gaacttgcca cgctttcttg acaatattac aacttacgaa      600

aaagtcaaga catacctgaa agaggagatc cctcagttgg agaaggaact ggtacgcgct      660

ggggcgagcc ttgtaagtca tgtcgacagt gtcttcacaa tcgacttttt tttagaggtg      720

tttacgcagt ccggcattga ccagtacaac gctcttattg gaaaaattgt caaccaggaa      780

caaggggagg tgaaaggatt aaatgagcgc atcaatttat acaatcaaca acataagcaa      840

gaggcgaagc tgccactttt taaacctttg tacaaacaga ttttaagcga tcgcgagcaa      900

ttgtcttggc ttgccgaagc atataattct gacaaagatt tattggactc gatccagaaa      960

tattatcaac tgttaatcga caaccaaatc tttgaacgta ttccgcgcct gatgcacacg     1020

ctggaaaagg caccgttaga taagatttgg atcacttacg atacgcaact gacaagtatc     1080

tcaaacacac tttacggctc ttggcgcgtc atcggtgagg ctctgggccg taacgctaag     1140

agtgagaagg agcgtaaatc atcgcaaaaa aaggcgttaa attactccct ggagtccatt     1200

aatcaggcca tcgccaagat gcccagcgat gaggagcttc cacctatcca gaaatacttt     1260

atcgcacttg ggagtaaccc gtccaaaaaa gacgctagct ccggtacgtt agtagataaa     1320

gtccgttcgt catataaagc ctgtcaagat attcttacaa atcctgatca tacgggcaag     1380

aaacttatcc aagacaaaaa gcaagttgat ctgttaaagc aattactgga tgacttattg     1440

atcttacagc gtttcatcaa acctttgctg tatagcaata acgagaatga gactcacaaa     1500

gatgaagttt tctatacaga attaacggat atcatggatt tgcttaatcc tattgtagga     1560

ctgtataaca aagtacgcaa ttatttgact caaaagccat attcgactga aaagtttaag     1620

atcaatttca aatcatcgtc cctgttggcg ggttgggacc gcaacaagga gaaagacaac     1680

ttaggggtaa tcttgaaacg cgaagataaa tactaccttg ctattatgga caaggcacac     1740

aacgccacat ttaaaaacaa gtcacttcct actcaaggcg aatgttacga gaaaatggaa     1800

tataagcttc tgccgggagc caataaaatg ctgccgaagg tatatatcac ctcgaaaaaa     1860

ggtatcgaat ccttccatcc atctgaagaa ttacaaaaaa agtacaaatt gggaacgcac     1920

aagaaaggcg cttcgttcaa cctgagcgac atgcgtgcat tgatcgatta cttcaaagaa     1980

tccttggaga agcacgagga gcattcacaa tttggattcc acttttcgga cacgagtacc     2040

tacgaagaca tttctggatt ttaccgtgaa gttgagcagc aggcttataa aattacgttc     2100

cgtaaagtat cggtcgaata catcgatcaa ttggttaacg aaggcaagct ttatctgttc     2160

cagatttata acaaagattt ttctccctat tctaaaggca cacctaattt acacactttg     2220

tactggaaga tgttgtttga tcccgcgaac ttacaggata ttgtttataa gttgaatggt     2280

gaggcggaag tattttttcg caaaaagtcg ctgcagtacg accgtcctac acatccaaaa     2340

ggccaaccta tcaataagaa aagtttgctg aatgaggggg aaacatccct tttcgactat     2400

gaccttatca aggaccgccg ctttactgta gacaaatttc agtttcatgt ccctattacg     2460

atgaatttca aggccacgca aggtacaaag gtcaaccaaa tggtccagga ggaggtcaag     2520

aaatccaaag gattccactt gatcggcatc gatcgcggag aacgcaacct tttatacatc     2580

gtcgtgatca atgaacgcgg ggagatcatt gagcagtgtt cattaaacaa gattgtgaat     2640

acataccagg aaaaggaaca caccgttgat tataaagctc tgttagagaa acgctcacag     2700

tctcgtcttg aggagcgcaa gtcgtggcaa actatcgaaa atatcaagga gttaaagggc     2760

ggatacttat cacaagttgt gcacaaaatc gctcagttga tgatcaaata taacgcaatt     2820

gccgttctgg aggacttaaa cttcggtttc attcgtactc gcaagaagtt tgaattttcg     2880

gtgtatcagg agttcgagaa gaaactgatc gataaattgg gttacgtggt agacaagaaa     2940

gccccgattc agcaggaggg tggtttactt caagcttatc agttaaccgc cccattcaag     3000

tcattccgtg agatggggaa acagaacggt tttttgtttt acgtacccgc gtggaacaca     3060

agcgcaatcg atccgcgtac cggatttgtc aatttactgg acacacgcta tgaatcgatc     3120

gcaaaaacca aagagcttat taagaaattg aaagacattc gttacaatag ccaaaaggac     3180

tggttcgaaa tcgatcttga ctataatgcc tttgggaacc gtgcgaaggg ttctcgctcg     3240

aaatggcgct tatgtagcta cggcgaacgt attgagcaca ctcgtaaaca ggatagtaat     3300

ggtcaagagg agagcgattc gatggtagta ttgacggaag catttaaaga tgtctttacg     3360

aagtatcaga tcgattaccg cgagaatctg aaggaacagt tacttctgca gtcagataaa     3420

gctttttttg tggatttcct gagcctgtta cgtttgacgc tgcaactgcg taacagttta     3480

tccaactccc ttattgacta tattctttcg ccggtagccg acgagaatgg ggagtttttt     3540

gactcgcgta aagcccttag taatgagcca caggatgctg acgccaacgg tgcataccac     3600

attgctttaa agggtttgtg ggtattggat aaaatccgta aaacggagaa ggttacgcca     3660

gctaagttgg cgctttccaa ccaggaatgg ttgtcgtttg cccaagagaa gccctttttc     3720

aatgagtga                                                             3729


<210>  16
<211>  3789
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  BoCpf1

<400>  16
atgcgcaagt tcaacgagtt cgtcggattg taccctattt ctaaaacctt acgttttgag       60

cttaagccga ttggtaagac gttggagcat attcagcgta ataaactttt ggagcatgac      120

gcggtacgcg ctgatgatta cgtaaaggtg aagaaaatta ttgacaaata tcacaaatgt      180

ttgattgacg aagcactgtc tggcttcacc tttgacacgg aagcagacgg tcgctcgaac      240

aatagtcttt ctgagtacta cctgtattac aatctgaaaa aacgcaacga acaggaacaa      300

aaaacgttta agacaattca aaacaatttg cgtaagcaga ttgtcaacaa acttactcaa      360

tcggagaagt acaaacgcat tgacaaaaaa gagttaatta cgactgactt accggacttt      420

ctgacaaacg agagcgagaa ggagcttgta gaaaaattta agaatttcac gacgtatttt      480

acagagttcc ataagaatcg taaaaatatg tactccaaag aagaaaaatc gaccgcaatt      540

gcatttcgct tgattaatga gaatttgccc aaattcgtag ataacattgc ggcgttcgag      600

aaagtcgtgt cttccccgct ggccgaaaaa atcaacgctc tttacgagga ctttaaggaa      660

tacctgaacg tagaggaaat cagtcgtgtg tttcgcttag actactatga tgaattgtta      720

actcaaaaac agattgatct ttacaatgct atcgtaggcg ggcgtacgga agaagacaat      780

aaaattcaga ttaaaggtct taaccaatac attaacgagt acaatcagca acagactgac      840

cgctccaatc gtttacctaa attgaagcct ctgtataagc aaattctgag cgatcgcgaa      900

agcgtaagct ggttgcctcc taaatttgac tctgacaaga atttgctgat caaaatcaag      960

gaatgctatg atgcactgtc tgagaaggag aaagttttcg acaagttaga gtctattctt     1020

aagagtttaa gcacttatga tttgagcaag atttacatta gtaatgacag tcaattgagt     1080

tacatctccc aaaagatgtt tggccgctgg gatatcattt ccaaggcaat ccgcgaggat     1140

tgtgcgaagc gtaaccctca gaaatctcgt gagtcactgg agaaatttgc agagcgcatt     1200

gataaaaaac ttaaaactat tgatagtatt tccatcgggg atgtagacga atgcttggcc     1260

cagttgggtg aaacttacgt aaaacgtgtc gaggattact ttgttgcgat gggagaatca     1320

gagatcgacg atgaacagac tgacacaacg tccttcaaaa agaacattga aggcgcctac     1380

gagagcgtta aggaacttct taacaatgca gacaatatca ccgacaacaa tcttatgcag     1440

gataaaggta atgtcgaaaa gatcaagaca ctgttggatg ctatcaagga tcttcaacgc     1500

tttattaagc cgttattagg gaaaggtgac gaagcggaca aagatggggt cttctatggt     1560

gaattcacga gcttgtggac caaattagac caagtgacac cgctttataa catggttcgc     1620

aactatttga ccagtaagcc ctatagtaca aaaaagatca agctgaattt cgagaattcc     1680

acccttatgg acgggtggga tttgaacaaa gagcctgata ataccactgt gattttttgt     1740

aaggacggtt tgtactattt gggtatcatg ggaaaaaagt ataatcgcgt ctttgtggat     1800

cgtgaagatt tgccgcacga tggagagtgt tatgataaaa tggaatataa actgcttcca     1860

ggagctaata agatgctgcc aaaagtattc ttctcggaaa ccgggattca acgttttctg     1920

ccttccgagg aacttttagg caagtacgag cgtggaacgc ataagaaggg tgccggcttt     1980

gaccttggag actgtcgcgc tttaatcgat tttttcaaga agtcgatcga acgccacgat     2040

gactggaaaa aattcgattt caagttttcg gacacttcta cctatcagga tatctccgag     2100

ttctaccgtg aggttgaaca acaaggctat aaaatgtcat ttcgcaaggt ctcagtggat     2160

tatatcaaat ctctggtaga ggaaggcaag ttgtatttat ttcaaatcta taataaagat     2220

ttttcggctc attccaaggg cacacccaat atgcacacat tgtactggaa gatgttgttt     2280

gacgaagaga acttaaaaga cgttgtttat aagcttaacg gagaggctga agtcttcttt     2340

cgtaagtcaa gtatcacagt ccaatcaccc acccatcccg caaattcccc aatcaagaat     2400

aagaataaag acaaccaaaa aaaagagagt aagtttgaat atgatttgat caaagatcgt     2460

cgttacaccg tcgataaatt tttgtttcac gttcctatca ccatgaactt caagagtgtg     2520

ggtggttcga atattaatca gttagttaag cgtcacattc gctcggcgac tgacttacac     2580

atcatcggca tcgatcgcgg tgagcgccat ctgctgtacc tgaccgtgat cgattcacgc     2640

ggcaatatta aagaacaatt ttctcttaac gagatcgtca atgaatacaa cggaaacacc     2700

taccgcaccg attaccacga actgcttgac acgcgcgaag gggagcgtac cgaagcacgt     2760

cgtaactggc aaacgattca gaatatccgc gaacttaagg aaggatattt gagccaggtg     2820

atccataaga tttccgaatt ggcaattaaa tacaacgcgg taattgtgct ggaagacctt     2880

aactttggct tcatgcgcag tcgtcagaag gtggaaaaac aggtatacca aaaatttgag     2940

aaaatgttga tcgacaagct taattatttg gtagacaaaa aaaagcctgt ggccgaaacg     3000

gggggattat tgcgcgccta tcaactgacg ggagaatttg agtcattcaa gactcttggc     3060

aagcaatctg gaatcttgtt ctacgtacca gcatggaata ctagcaagat tgaccctgtt     3120

acaggcttcg taaatctttt cgatacacat tacgagaata ttgagaaagc gaaggtgttc     3180

ttcgataagt ttaagtcgat tcgctacaat tcggacaaag attggtttga gttcgtcgtc     3240

gatgactaca ctcgtttttc tcccaaggct gagggaactc gtcgtgattg gacgatttgt     3300

actcagggta aacgtatcca gatttgtcgc aaccatcagc gcaacaatga atgggaaggg     3360

caagaaatcg accttacgaa agccttcaag gaacacttcg aggcgtatgg tgtagacatt     3420

tctaaggatt tacgtgagca aattaacaca cagaataaga aagaattttt tgaagaatta     3480

ttgcgtttac ttcgcttgac gctgcagatg cgcaattcaa tgccgtcctc ggatattgat     3540

taccttatct ctccagttgc taatgacact ggatgtttct ttgactctcg caaacaggcg     3600

gaattgaagg aaaatgccgt tttgccgatg aacgcggatg ctaatggagc gtacaacatc     3660

gctcgtaaag gacttttggc gattcgcaaa atgaaacagg aggagaacga ctccgcgaaa     3720

attagcttag ccattagtaa taaggagtgg ttgaagttcg cacagactaa accgtatctg     3780

gaagattga                                                             3789


<210>  17
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1

<400>  17
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttcaaa      540

gggttccacg agaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgaa cggctgggat aaaaataagg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  18
<211>  3933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HkCpf1

<400>  18
atgttcgaaa agcttagtaa catcgtaagt atttcgaaga cgatccgctt caaattgatt       60

ccagtaggta aaaccctgga gaatattgaa aagcttggca aactggaaaa ggactttgag      120

cgctcggact tttacccaat cctgaagaat atctcggatg actattaccg ccaatacatc      180

aaagaaaaat tgtccgattt aaacctggat tggcagaagc tttacgatgc tcatgagttg      240

ctggactcca gtaagaaaga gtcgcagaaa aaccttgaga tgatccaagc tcagtatcgc      300

aaagtccttt tcaacatttt atcgggcgag cttgataaga gcggagaaaa gaatagcaag      360

gacctgatta agaataataa agccttatac ggaaagttgt tcaaaaaaca atttattctg      420

gaggtcctgc ctgactttgt gaataataac gattcctatt ctgaagaaga tcttgaggga      480

cttaatcttt atagcaaatt tacaactcgc ttgaaaaact tctgggaaac acgtaaaaat      540

gtcttcactg ataaagacat tgtcacggcg attcccttcc gtgcggtgaa tgagaacttt      600

ggattttact acgataacat taaaattttt aacaaaaata ttgagtatct ggagaacaaa      660

atcccaaatt tggaaaatga gttgaaggag gccgatatcc ttgacgacaa tcgctctgtg      720

aaagattact ttacaccaaa cggattcaat tacgtcatca cccaagacgg tattgacgtc      780

taccaagcaa ttcgtggcgg gttcaccaaa gagaatggcg agaaggtcca gggtatcaac      840

gagattttga atcttacaca gcaacagctt cgccgcaagc cggaaactaa aaacgttaag      900

cttggagttt tgacgaagtt gcgtaaacaa atcctggagt atagcgagag cacaagtttt      960

ttgattgatc agattgaaga tgataatgat ttagtagacc gtattaataa gttcaacgta     1020

tcgttctttg aaagcacaga agttagcccc tcattattcg aacagatcga acgcttgtat     1080

aatgccctga agtctattaa aaaagaggaa gtatatattg acgctcgtaa tacacagaaa     1140

ttctcccaga tgcttttcgg tcaatgggac gttatccgcc gcggttacac ggtcaagatt     1200

actgaagggt ctaaggaaga aaagaagaag tacaaagagt atctggagtt agatgaaaca     1260

tctaaggcta agcgttatct taatattcgt gaaattgaag aattagtcaa cttagtagag     1320

gggtttgagg aggtagacgt cttctcagtc ttgctggaga agtttaaaat gaataatatt     1380

gagcgctcag agtttgaggc gccaatttat ggaagcccta ttaaattaga ggcgattaag     1440

gagtacttgg agaaacattt ggaggagtat cacaaatgga agctgttgct tattggaaat     1500

gacgaccttg ataccgacga gaccttctac cctctgctta atgaggtcat ttctgattac     1560

tatatcatcc cactttataa tcttacgcgc aactatttga cccgcaagca cagtgacaag     1620

gacaagatca aagtgaactt tgactttcct accctggctg acgggtggag cgaatcgaag     1680

atctctgaca accgctccat tatcttgcgt aaggggggct attattactt ggggatctta     1740

atcgataata agttattaat taataaaaaa aataagtcaa aaaagattta cgagatcctg     1800

atttacaatc agatccctga attctctaaa tcaattccaa attacccctt tacaaagaaa     1860

gttaaggaac acttcaaaaa caatgttagc gacttccagt taattgatgg ctatgttagc     1920

ccgcttatta ttactaagga aatctatgat attaaaaagg aaaagaagta caaaaaggac     1980

ttctataaag acaacaatac caacaagaac tacttgtata caatttacaa atggatcgaa     2040

ttctgtaagc agtttcttta taagtacaag ggacccaata aggaatccta caaggaaatg     2100

tatgattttt ccacgttaaa ggacacgtcg ttatacgtta acttgaatga cttctacgcc     2160

gatgttaact cttgtgctta tcgcgtcctg ttcaataaga tcgacgagaa tactattgac     2220

aacgcggttg aagatgggaa gctgctgtta tttcaaattt acaataaaga ctttagccct     2280

gaatcgaaag gcaaaaagaa tttgcacaca ctgtactggc ttagcatgtt cagcgaagag     2340

aaccttcgca cgcgtaaatt gaagctgaat ggccaggcag agatctttta ccgcaaaaag     2400

ctggagaaga aaccgattat ccataaggaa ggcagtatcc tgcttaacaa gatcgataaa     2460

gaagggaaca caatccccga aaacatttac catgagtgct accgttattt aaataaaaaa     2520

attggtcgcg aggatttgtc agatgaggcg attgcgcttt tcaataaaga cgtcttgaaa     2580

tataaggaag ctcgcttcga tattattaag gaccgccgtt actccgagtc tcaatttttc     2640

tttcatgtgc cgatcacgtt caactgggat atcaagacca acaaaaacgt taaccaaatc     2700

gtgcagggga tgattaaaga tggggaaatt aagcacatta tcgggattga ccgtggcgag     2760

cgtcatttgc tgtactattc cgtcatcgac ttagaaggta atatcgttga acaagggtct     2820

cttaatacct tggagcagaa tcgctttgat aactcgaccg taaaggtaga ttaccaaaac     2880

aaacttcgca cgcgtgaaga agatcgtgac cgtgctcgca aaaattggac gaatattaac     2940

aaaatcaaag aactgaaaga tggttacctg tcccatgtgg tccacaagtt aagtcgcttg     3000

atcattaaat atgaagcaat tgtaatcatg gaaaacttga accaaggttt taagcgcgga     3060

cgttttaagg tagagcgtca agtttaccaa aagttcgagt tggcacttat gaacaagttg     3120

tccgccttgt cgttcaaaga gaagtacgat gaacgcaaaa acttggagcc atcaggaatc     3180

cttaatccta tccaagcatg ttacccagta gatgcctatc aagagttgca aggtcagaac     3240

gggatcgtct tttacttgcc agccgcttat acctccgtta ttgacccggt gactggattt     3300

acaaatttat ttcgcctgaa aagtatcaac agctcgaaat atgaggaatt tattaaaaag     3360

tttaaaaaca tttactttga caatgaagaa gaggacttca aattcatttt taactacaag     3420

gatttcgcaa aggctaatct tgtgatttta aacaatatta agagcaaaga ctggaagatt     3480

agcacgcgcg gtgagcgcat tagctacaat tccaagaaaa aggagtattt ctatgttcaa     3540

cctactgagt tcttaatcaa taaacttaaa gaattaaata tcgattacga aaacattgac     3600

atcatcccat taattgataa tctggaggaa aaggccaaac gtaagattct taaggcgctt     3660

tttgatacct tcaagtactc cgttcaactt cgtaattatg actttgagaa cgattacatc     3720

atctctccga cagcagacga caatggcaat tattacaact caaatgaaat cgacatcgac     3780

aaaacgaatc tgcctaataa cggggacgct aacggtgctt ttaatatcgc tcgcaaaggg     3840

ttgctgctga aggaccgtat cgtcaactct aatgaatcta aggttgacct taaaatcaag     3900

aacgaagact ggatcaattt tatcattagc tga                                  3933


<210>  19
<211>  3675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lb4Cpf1

<400>  19
atgggtttgt atgatggctt cgttaatcgt tatagtgtca gtaaaaccct gcgtttcgaa       60

cttattccac aagggcgcac tcgtgaatac atcgaaacca atggaatcct gtcagatgac      120

gaggagcgcg ccaaagacta caagacaatc aagcgtctga ttgacgagta ccacaaagac      180

tatatttccc gttgccttaa aaatgtaaac atctcttgtt tggaggagta ctatcacctg      240

tataactcct ctaaccgtga taagcgtcac gaggagctgg atgcattatc cgaccagatg      300

cgcggcgaga ttgcatcttt tttaactggg aacgacgagt ataaggaaca gaaaagtcgc      360

gacatcatta ttaatgaacg tattattaac tttgcgtcta cggacgaaga gttggcggca      420

gtcaagcgct tccgcaagtt cacaagttat tttactgggt ttttcactaa ccgcgagaac      480

atgtactcgg ccgagaaaaa atctacggcc atcgcacatc gtatcattga cgtgaatctt      540

ccaaagtacg tggataacat taaggcattt aacacggcta tcgaagcggg agtctttgat      600

atcgctgaat ttgaatcaaa tttcaaggcc attaccgatg agcacgaagt aagcgattta      660

cttgacatca ccaaatactc tcgctttatc cgtaatgagg acattatcat ttacaatact      720

cttctggggg gtattagcat gaaagacgaa aaaattcagg ggctgaatga gttaattaat      780

cttcataacc agaagcatcc tggtaagaaa gtgcctttac ttaaggtcct ttacaagcag      840

attttggggg attcacagac tcacagtttt gtcgacgatc agttcgagga cgaccaacag      900

gtcatcaacg ccgtgaaggc ggttacggac accttttcag agacgctgtt aggctctttg      960

aaaattatca ttaataacat tggtcattac gaccttgacc gtatttacat taaagcggga     1020

caggatatca ccacgctgag taaacgtgca ttaaatgatt ggcacattat caccgagtgc     1080

ttggagtcag aatacgatga taaattccct aagaacaaga aaagtgatac ttacgaggaa     1140

atgcgtaacc gctacgttaa gtcctttaag tcgtttagta ttgggcgcct taacagtctg     1200

gtaaccacat atacagaaca agcgtgcttc cttgagaact acttgggctc gtttgggggc     1260

gatactgata agaactgttt gacagatttt accaactcac ttatggaagt agaacatctg     1320

cttaattcag agtatcctgt gacaaatcgt cttatcacgg attacgaatc cgtgcgcatt     1380

cttaagcgcc tgttagattc agaaatggaa gttattcact tcttaaagcc gttgttaggg     1440

aatggaaacg aatcagataa agatcttgtt ttttacgggg aatttgaggc agaatatgag     1500

aaattgctgc ctgtcatcaa agtctataac cgcgtgcgta actatttaac tcgcaagccg     1560

ttttcaacgg agaagatcaa attaaacttt aactccccaa ctcttctgtg cggatggtct     1620

cagagtaaag agaaagaata catgggcgtg attttgcgta aagacggaca gtattacctt     1680

ggtatcatga ctccgagcaa taaaaagatt ttcagcgaag cgcccaagcc tgacgaagat     1740

tgttacgaaa aaatggtctt acgctacatt ccccacccct accagatgct gcctaaggtg     1800

ttcttctcca agtcgaacat tgcctttttt aacccttcgg atgaaatctt gcgcattaaa     1860

aagcaggagt catttaagaa agggaagagt tttaatcgcg atgactgcca caaattcatt     1920

gacttctata aagactcaat caaccgccac gaggagtggc gcaaatttaa cttcaaattt     1980

tctgatacag actcttatga agatatctcg cgtttttaca aagaggtaga gaaccaggct     2040

ttttccatga gctttactaa gatccccacc gtatatattg attcattagt ggacgaggga     2100

aagctttacc tgttcaaact gcacaacaag gattttagcg aacattctaa gggaaagccg     2160

aacttacata cggtttactg gaacgcttta ttctcagaat acaacttaca gaacacggtc     2220

tatcaattga acgggtctgc ggagatcttc ttccgcaaag cctcgattcc agaaaatgag     2280

cgcgtaattc acaagaaaaa tgttcctatt actcgcaaag tagcagaact taatggaaag     2340

aaggaagttt cggtctttcc ttatgatatc atcaaaaacc gccgctacac agtagacaag     2400

tttcaatttc acgtgccact gaaaatgaat ttcaaggccg atgaaaagaa gcgtattaac     2460

gacgacgtaa tcgaagccat ccgtagtaac aaggggattc acgtcatcgg catcgatcgt     2520

ggtgaacgca atcttctgta cttaagctta attaacgagg aagggcgtat catcgaacaa     2580

cgttcgttga atattatcga tagtggagag gggcacactc agaactaccg cgatctgtta     2640

gactcacgtg aaaaagatcg cgaaaaagct cgtgagaact ggcaggaaat ccaagaaatc     2700

aaagatttga agactggcta tttgtcccag gcgatccata caatcacgaa atggatgaag     2760

gagtacaatg caatcattgt tcttgaagat cttaatgacc gctttacaaa tggccgtaag     2820

aaagttgaaa agcaagtgta tcagaagttc gagaaaatgt taattgataa gcttaattat     2880

tacgtcgata aggacgagga gtttgaccgt atgggtggaa ctcaccgcgc ccttcaattg     2940

acggagaagt tcgagtcatt tcagaaactt ggccgccaga cggggtttat tttctatgtg     3000

cctgcatgga atacctcgaa gttagaccca acaactgggt ttgtagactt gctttatccg     3060

aaatataaat ctgtagatgc gaccaaggat tttatcaaga agtttgactt tatccgcttt     3120

aatagcgaga agaactactt tgagtttggc cttcattatt ccaactttac tgagcgcgct     3180

atcggttgtc gcgatgaatg gattttatgc tcttacggta accgcattgt taatttccgc     3240

aacgccgcaa agaataacag ttgggactac aaagaaatcg acattacgaa acagttactg     3300

gacctgtttg aaaaaaacgg aattgacgta aagcaagaaa atttgatcga cagcatctgt     3360

gaaatgaaag ataaaccttt tttcaagagc cttatcgcga acatcaaact tatcttacag     3420

atccgcaact ccgcgtcggg gactgatatc gactatatga tctctcccgc tatgaatgac     3480

cgcggggagt tctttgacac tcgtaaaggt ttgcagcaat tacctcttga cgccgatgcg     3540

aatggtgcat acaacatcgc gaagaaggga ttatggatcg ttgatcaaat ccgtaatacg     3600

actggcaaca atgtgaagat ggccatgtcc aaccgcgaat ggatgcactt tgcacaggaa     3660

agtcgtctgg cttga                                                      3675


<210>  20
<211>  3621
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lb5Cpf1

<400>  20
atggagaatt attatgattc attgacgcgc caatatccgg ttactaagac cattcgccaa       60

gaacttaaac ccgtggggaa gactttagag aacattaaga atgcggaaat catcgaggcc      120

gacaagcaaa aaaaggaagc atacgtcaaa gtgaaagagc ttatggatga atttcataaa      180

agcatcattg agaaatcatt ggtgggtatc aagctggacg ggttgtcgga atttgaaaag      240

ctgtataaga ttaagacaaa gaccgacgag gacaagaatc gtattagcga gctgttctat      300

tacatgcgca aacagatcgc agacgcgctt aaaaacagcc gtgattacgg gtacgtagat      360

aataaagatc ttatcgaaaa gatcttacca gaacgcgtta aggatgaaaa ctccctgaat      420

gccttgtcct gttttaaggg atttacgact tatttcacgg attattataa aaaccgcaaa      480

aacatctata gtgatgaaga gaaacattcc acggtggggt atcgctgcat caacgagaac      540

ttattgattt tcatgtctaa tattgaggta tatcaaatct ataagaaggc gaacatcaag      600

aatgacaatt acgatgaaga gaccctggat aagaccttca tgatcgagtc gttcaacgag      660

tgcttaacgc agtctggagt tgaggcctat aattcggtag tcgcctctat caagacggcg      720

acaaatctgt atattcaaaa aaataacaag gaggaaaact tcgttcgcgt gcctaagatg      780

aaggtgttgt tcaaacaaat tctgtctgac cgtacgtcat tattcgacgg tctgattatc      840

gagtctgatg acgagttact ggacaaactt tgtagttttt ctgcggaggt agataagttc      900

ttgccgatca atattgatcg ctacatcaag accctgatgg acagcaacaa tggcacgggc      960

atttatgtaa agaacgatag cagtctgacg accttaagca actatttgac agactcgtgg     1020

tcgtcaattc gtaatgcatt taacgagaac tacgacgcta agtataccgg taaagtcaac     1080

gataagtacg aggaaaagcg tgagaaagca tataaatcca atgactcctt tgaacttaat     1140

tacatccaaa acttattagg aattaatgtg attgacaagt atattgagcg tatcaacttt     1200

gacatcaagg aaatctgtga ggcttataaa gagatgacca aaaattgctt cgaggatcat     1260

gataagacaa aaaaattgca gaagaatatt aaagctgtag cttccattaa gagttatctt     1320

gacagtctga agaacattga gcgtgatatc aagctgttaa acgggacagg attggagtcg     1380

cgcaatgaat ttttttatgg tgaacagagt acggtgttag aagaaatcac gaaagtagat     1440

gagttatata atattacccg caattacctt acgaaaaagc ccttttctac cgaaaaaatg     1500

aagttaaatt tcaacaatcc ccaactttta ggaggttggg acgttaacaa ggagcgtgat     1560

tgttacggtg tgattctgat taaagacaat aactattact tgggtatcat ggataaatcg     1620

gcgaataaga gttttcttaa tattaaggaa agcaaaaacg aaaatgcgta caagaaggtt     1680

aactgcaagc tgcttcctgg acccaacaag atgtttccaa aggtgttctt cgctaagtcg     1740

aacattgact actacgatcc gactcacgaa atcaagaagc tttacgacaa gggaactttt     1800

aaaaagggga attctttcaa tttagaagac tgccataagt tgattgattt ctataaggag     1860

tcgattaaaa agaatgacga ctggaaaaac tttaacttta atttcagtga taccaaggac     1920

tatgaggata tttcgggatt ctttcgtgag gttgaagcgc aaaattataa gattacatat     1980

accaacgtta gctgcgattt cattgagtca cttgttgacg agggtaagct ttatttattt     2040

caaatctaca acaaggattt ttcagagtac gctaccggca atttgaactt acatactctg     2100

tacttaaaaa tgcttttcga cgaacgcaac ttaaaagact tatgcatcaa gatgaacggc     2160

gaggccgagg tgttctaccg ccccgcgtca attttggatg aagacaaagt ggtgcacaaa     2220

gcaaatcaga aaattacgaa caagaacaca aactcgaaaa agaaagaaag tattttcagc     2280

tatgacattg taaaagacaa acgctacact gtcgataaat ttttcattca tttgcccatt     2340

acgttgaact ataaggagca aaatgtatcg cgtttcaacg attacattcg tgaaatttta     2400

aaaaagtcta agaacattcg tgtgattggc attgatcgcg gagagcgtaa ccttctgtat     2460

gttgtggtct gtgactctga tgggtcaatt ttgtatcagc gttccattaa tgagatcgta     2520

agcggttccc acaaaacaga ttaccacaag cttttggaca acaaggaaaa agaacgtttg     2580

tccagccgtc gtgattggaa gactatcgaa aatattaaag atctgaaggc gggatatatg     2640

tcgcaagttg ttaatgaaat ttataatttg attttgaagt ataatgctat cgttgtctta     2700

gaagacctta acattggttt taagaatggc cgcaagaagg tggaaaaaca agtgtaccag     2760

aattttgaaa aagccctgat cgacaaactg aactacctgt gtatcgacaa gacgcgcgaa     2820

caattgtcac catcatcacc aggaggagtc ttaaatgcct atcaactgac tgccaagttc     2880

gagagttttg agaagattgg aaaacaaaca ggatgcatct tctacgtgcc agcctacctg     2940

acttcccaga tcgacccaac gacagggttt gtaaacttgt tctatcagaa agatacttcc     3000

aagcaaggcc ttcagctttt cttccgtaag tttaaaaaga tcaacttcga taaggtggcc     3060

agcaattttg aatttgtttt cgattacaat gactttacta ataaagctga gggtactaag     3120

acaaattgga ccatctcaac tcagggtacg cgtatcgcca aataccgctc agatgacgca     3180

aatggaaagt ggatctcgcg tactgtgcat ccgaccgaca ttatcaaaga agctctgaat     3240

cgtgagaaga ttaactataa tgatggccat gacttgattg atgagattgt aagtattgag     3300

aagagcgctg tgctgaagga gatttactac ggatttaagc tgaccctgca attacgtaat     3360

tcgactttgg ctaatgagga ggagcaggaa gattacatca tctccccagt aaaaaacagt     3420

tcgggaaact acttcgattc ccgcatcaca tcgaaggagt taccttgcga tgctgacgcc     3480

aatggcgctt acaacatcgc acgcaaaggt ttatgggctt tagaacaaat tcgcaacagt     3540

gagaacgtat caaaagtaaa attagcgatc tcgaacaagg agtggtttga gtacacgcaa     3600

aacaatatcc caagtttgtg a                                               3621


<210>  21
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1

<400>  21
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt cacgactgcc tttacgggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgggtggat gggataagga caaagagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  22
<211>  3669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  OsCpf1

<400>  22
atggagaccg aaattttaaa gtacgatttt tttgaacgcg aaggtaagta tatgtattat       60

gatggcctga caaaacagta cgctttaagt aagacaatcc gtaacgagct ggtgccgatt      120

ggtaaaactc ttgacaacat caagaaaaac cgtattttag aagcggatat caaacgcaaa      180

tctgattatg agcacgttaa aaagttgatg gatatgtatc ataaaaaaat cattaacgag      240

gcgcttgaca actttaaatt gtctgttctg gaagacgcgg cggacattta cttcaacaaa      300

cagaacgatg aacgtgatat tgatgctttc ttgaaaattc aggacaaact gcgcaaggaa      360

atcgtcgaac agttgaaggg ccatacggac tactccaaag tcggaaataa ggacttcttg      420

ggtctgctta aggccgctag tacagaagag gatcgtatct tgattgagag cttcgacaac      480

ttttacacat atttcacatc gtacaataag gttcgttcaa acctgtactc tgccgaagac      540

aagtcgtcga cagtagcgta tcgtctgatc aatgaaaatt taccaaagtt tttcgataat      600

atcaaagcct atcgcacggt tcgtaacgct ggggtaatct ccggtgacat gtccattgtc      660

gagcaagatg agctgtttga ggtagacacg tttaaccata ctctgacaca atatgggatc      720

gacacgtata accatatgat tggccagttg aacagtgcaa ttaatcttta caatcaaaag      780

atgcatggcg ctggttcttt taagaagtta cccaaaatga aggagttata caagcagctg      840

cttactgagc gtgaggagga attcatcgaa gaatataccg atgacgaagt gctgatcacg      900

agtgttcata attacgtttc atacttgatc gattacctga attccgacaa ggttgagtct      960

ttttttgata ctttacgtaa gagcgacggt aaagaggtat ttatcaaaaa cgatgtaagt     1020

aaaactacga tgtctaacat tttatttgac aattggagca ccattgatga tttgattaac     1080

catgaatatg attcagctcc agaaaacgtt aagaaaacga aagatgacaa atatttcgag     1140

aaacgtcaaa aggatttaaa aaagaacaag tcgtactctt tgtcgaagat tgctgctctt     1200

tgtcgcgata caacgattct ggagaagtat atccgtcgtt tggtagacga cattgaaaag     1260

atttacacaa gtaacaatgt cttcagcgac attgttttat ccaaacatga tcgcagtaag     1320

aaattgagca agaatacgaa tgccgtacaa gccattaaga atatgcttga ttctatcaaa     1380

gactttgagc atgatgtcat gcttattaac ggttcaggac aggagatcaa gaaaaatctt     1440

aacgtttact cagaacagga agcattggcc ggcatcttac gccaggtcga ccacatctat     1500

aatcttacac gcaactactt gacaaaaaag cccttctcca cagaaaaaat caaactgaat     1560

tttaatcgcc cgacgttcct ggatgggtgg gacaaaaata aggaggaagc aaacctgggc     1620

atcttgttaa tcaaagataa tcgctactac ctggggatca tgaatacaag tagtaacaag     1680

gcttttgtaa accccccaaa agccattagc aatgatattt ataaaaaggt cgattacaaa     1740

cttttgcctg gccccaacaa gatgttgccc aaggtgtttt ttgcgacgaa gaacattgca     1800

tactatgccc ccagcgagga gttgctgtcg aaatatcgta aagggacgca caagaaagga     1860

gatagtttca gcatcgacga ttgtcgtaac ctgattgatt tttttaaatc gtcaattaac     1920

aaaaacactg attggtcgac gtttggattc aatttctctg atactaacag ttataacgat     1980

atctcggact tttatcgtga agtcgagaaa cagggctaca aattatcgtt cacggatatt     2040

gatgcttgtt acattaaaga cttggtcgat aataatgaat tgtatctgtt tcagatttac     2100

aacaaggact tttcccctta tagtaaaggt aaattaaatc tgcatacact gtacttcaaa     2160

atgttatttg atcaacgcaa ccttgacaac gtagtctata agctgaatgg tgaggcggaa     2220

gtattttacc gccctgcatc catcgagtca gacgagcaaa ttattcacaa gtcaggacaa     2280

aacattaaga ataagaatca gaaacgctca aattgcaaga agacgagcac tttcgactat     2340

gatattgtga aagatcgccg ttattgcaaa gataagttta tgcttcattt gcccatcact     2400

gttaatttcg gtacaaatga gagcggaaaa tttaatgaat tggttaacaa cgcgattcgc     2460

gctgataagg acgttaatgt gattgggatc gaccgtggtg aacgtaattt actttatgta     2520

gttgtcgttg acccctgcgg taagattatc gaacagatct cgcttaacac aattgtggat     2580

aaagagtatg acatcgagac ggattaccac caattattgg acgaaaaaga ggggtcccgt     2640

gataaggccc gcaaggattg gaatacgatt gagaacatca aagaattgaa ggagggctat     2700

ctgtcgcaag ttgtaaatat cattgccaag ttggtactga aatatgacgc catcatttgt     2760

ttagaagact taaactttgg atttaaacgc ggacgccaaa aagtagaaaa gcaggtgtac     2820

cagaaattcg aaaagatgct gatcgataag atgaattatt tagtgttgga taaatcgcgc     2880

aaacaggaat cccctcaaaa accaggcggc gcgttaaatg ccctgcagtt gactagtgcc     2940

tttaagtcgt ttaaggagtt gggtaaacag acaggtatca tctactatgt accagcgtat     3000

ttgacgagta aaatcgatcc caccaccgga ttcgcaaatc ttttttacat caagtatgaa     3060

tccgtcgata aagcccgtga cttcttcagc aaatttgatt ttatccgtta taaccaaatg     3120

gataactatt tcgaatttgg attcgactac aaatcgttca cagaacgcgc gtcagggtgt     3180

aagtccaaat ggattgcttg cacgaacggc gaacgtatcg tgaaatatcg caattctgat     3240

aaaaataact ctttcgatga taagacagtc atcttgaccg atgaatatcg ctcgctgttc     3300

gacaaatact tacaaaacta tattgatgag gacgatctta aggaccaaat cttgcagatt     3360

gattctgcag acttttacaa gaatcttatt aaactgttcc agttgaccct tcaaatgcgc     3420

aatagcagct ccgacggaaa gcgtgattat attatttccc ccgtgaagaa ttatcgcgag     3480

gagttctttt gcagtgagtt cagtgatgac accttccctc gtgacgccga cgcaaatgga     3540

gcatataaca tcgctcgcaa agggctgtgg gtcatcaagc agatccgtga gacaaaaagc     3600

ggcacgaaaa tcaacttggc gatgagcaat agcgagtggt tggaatacgc ccaatgcaat     3660

ttgctttga                                                             3669


<210>  23
<211>  3897
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TsCpf1

<400>  23
atgaccaaga ctttcgatag cgagttcttc aacctgtaca gcttgcaaaa aacggtccgt       60

tttgagttaa agccagtcgg tgaaactgca tcctttgtcg aggatttcaa aaatgaagga      120

ttaaagcgcg tagtgagcga ggacgaacgt cgcgcggtcg attaccagaa ggtgaaggaa      180

atcatcgatg attaccatcg cgatttcatc gaagaatccc ttaactattt tcctgagcaa      240

gtgagtaagg acgcccttga gcaggcgttt catttatatc agaagttgaa agccgctaag      300

gtagaagagc gcgagaaagc gttgaaggaa tgggaagccc tgcaaaaaaa attgcgtgaa      360

aaagtagtga agtgtttctc cgacagcaat aaagcgcgtt tctctcgtat cgataagaaa      420

gagctgatca aggaagatct tatcaactgg ttagtcgccc aaaatcgtga agacgacatt      480

cctactgtcg agacgttcaa taattttacg acgtacttca caggttttca tgaaaatcgt      540

aagaacattt attcaaaaga cgaccatgct accgctatca gtttccgctt gatccatgag      600

aacctgccaa agtttttcga caacgtcatt tcttttaaca agttaaaaga aggttttccc      660

gagcttaagt tcgataaggt gaaagaagat ttggaagtag attatgactt gaaacacgct      720

tttgaaattg agtactttgt taattttgtt acccaggccg gtatcgacca atacaattac      780

ttgttaggcg gaaagacgtt agaagatgga acaaagaaac aaggaatgaa tgagcaaatt      840

aacttattca agcagcaaca gacgcgcgac aaggcacgtc agattcccaa attgattcca      900

ctttttaaac aaatcctgtc tgagcgtaca gagtcccaga gtttcattcc aaaacagttt      960

gaatccgacc aagagctgtt tgattcgttg caaaaattac ataacaactg tcaggataag     1020

ttcacggttt tgcaacaagc catcttaggc ttagcagaag cggatcttaa aaaggtattc     1080

atcaaaacgt cagatttgaa cgcgctgagt aacaccattt tcggtaacta ttcggtattc     1140

tctgatgcgc tgaacctgta caaagaaagt cttaaaacta aaaaagccca agaggccttt     1200

gaaaaacttc ccgcacatag catccacgat ttaatccaat accttgaaca gtttaacagc     1260

tctctggacg cagagaaaca acaatcgacc gatacggtat tgaactattt cattaagact     1320

gacgaattgt atagccgctt tatcaagagc acatctgagg cctttacgca agtgcagcct     1380

ctttttgaat tggaggctct gtcgtcaaag cgccgcccac cagaatcaga agacgaagga     1440

gcgaagggtc aggaaggatt cgagcagatt aagcgtatta aagcttacct tgacaccctg     1500

atggaggccg tacacttcgc taagccgctt tacttggtca aaggccgtaa gatgatcgaa     1560

ggcttggaca aagaccaatc tttttacgaa gcattcgaga tggcatatca ggaattagaa     1620

agtcttatta ttcctattta caataaggct cgttcatatc ttagccgcaa accgtttaag     1680

gcggataaat tcaaaattaa ctttgacaac aacactctgt tatctggctg ggacgctaat     1740

aaagaaactg ctaatgcgtc gatcctgttt aaaaaagatg gactttatta cttagggatt     1800

atgcctaaag ggaaaacgtt tctttttgat tatttcgttt cgagtgaaga ctcggaaaaa     1860

ctgaaacagc gccgccagaa aacggcagag gaagctttgg cacaagacgg ggagtcatat     1920

ttcgaaaaga ttcgctataa actgctgccc ggcgcaagca aaatgttgcc gaaggtattt     1980

ttttccaaca aaaatattgg gttctataac ccgtcagacg atatcttgcg tattcgcaat     2040

acagcgtcac acactaagaa tggcactccg cagaaagggc atagcaaggt ggaatttaac     2100

ttgaatgact gtcacaagat gatcgacttt tttaagtctt cgattcaaaa gcacccagag     2160

tgggggtcct ttggatttac tttctccgat actagcgact tcgaagatat gagtgcgttt     2220

tatcgtgaag tggagaacca gggatacgtt atttcattcg acaagatcaa ggaaacctac     2280

attcagagcc aagtcgaaca ggggaacctt tatctgtttc aaatctacaa caaggatttt     2340

agtccctact ctaagggcaa acccaactta cacaccttat actggaaggc tctttttgag     2400

gaagcaaacc ttaataatgt agttgcgaaa ttaaatggcg aggctgaaat ttttttccgc     2460

cgtcatagta tcaaagcctc tgacaaggtc gtacacccgg ccaaccaagc aatcgacaac     2520

aaaaatcccc atacagagaa aacgcaaagt acgtttgaat atgatcttgt gaaggacaag     2580

cgctatactc aagataagtt cttcttccac gtcccaatca gtctgaattt taaagcgcag     2640

ggtgtttcga aatttaacga taaagttaac gggttcctta aagggaaccc ggatgtaaat     2700

atcattggga tcgaccgtgg ggaacgtcat ttgttgtact ttacggtagt aaatcagaaa     2760

ggtgagattt tggtgcaaga gtcacttaat acactgatga gcgataaggg tcacgtgaac     2820

gattatcagc agaagttaga taagaaggag caggaacgtg acgccgcccg caaatcttgg     2880

acaactgtcg agaacattaa ggaactgaaa gaaggttatc tgtctcatgt ggttcacaag     2940

ttagcgcatc tgatcattaa atacaatgcg atcgtgtgtc tggaagactt aaatttcggt     3000

tttaagcgtg gacgctttaa agtcgaaaaa caggtctatc aaaagttcga aaaggcgctg     3060

atcgataagc tgaactattt agttttcaag gagaaggagt taggtgaggt cgggcactac     3120

ttaacagctt accaactgac agctccattc gagtccttta aaaagttagg caagcagagc     3180

ggaatccttt tttatgttcc cgctgactat acatcgaaga tcgacccgac cacgggcttt     3240

gttaacttcc ttgatctgcg ctatcaaagc gttgaaaagg caaagcaact tctttcagat     3300

tttaatgcca ttcgtttcaa ttctgtccaa aactactttg agttcgaaat cgactacaaa     3360

aaattgacac caaagcgtaa agttgggacc cagtcaaagt gggtgatctg cacgtatgga     3420

gatgtccgtt atcagaatcg tcgcaatcaa aaggggcact gggaaactga ggaggtaaat     3480

gtgactgaga aattaaaggc tttgttcgcg agcgactcta aaaccactac agtcattgat     3540

tacgcgaatg atgacaactt aatcgacgtt atcttagagc aggacaaagc atcgtttttt     3600

aaggaattat tgtggctgct gaagctgacg atgacgttac gtcatagcaa gatcaagtct     3660

gaagatgact ttatcttgag ccctgtcaag aacgagcagg gcgaatttta cgacagtcgc     3720

aaagcaggtg aagtctggcc gaaggatgcc gacgctaacg gtgcgtatca cattgcgctt     3780

aagggactgt ggaacctgca acagattaat cagtgggaaa aaggtaagac attgaatctg     3840

gcaattaaaa accaggattg gttttccttt atccaagaga agccatacca agagtga        3897


<210>  24
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-Orf1ab-RPA-F

<400>  24
ctaacatgct taggataatg gcctctcttg ttc                                    33


<210>  25
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-Orf1ab -RPA-R

<400>  25
gtaagcgtaa aactcatcca cgaattcatg atc                                    33


<210>  26
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS-upE-RPA-F

<400>  26
ctcgcttatc gtttaagcag ctctgcgcta ctatg                                  35


<210>  27
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS-upE-RPA-F

<400>  27
ctcgcttatc gtttaagcag ctctgcgcta ctatg                                  35


<210>  28
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS-Orf1-RPA-F

<400>  28
ctattcccac acagttgttc ccactcttat                                        30


<210>  29
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MERS-Orf1-RPA-R

<400>  29
cttgaggctt ctccaatgct ataagtgtac                                        30


<210>  30
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1-K180R

<400>  30
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttccgt      540

gggttccacg agaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgaa cggctgggat aaaaataagg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  31
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1-E184R

<400>  31
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttcaaa      540

gggttccacc gtaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgaa cggctgggat aaaaataagg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  32
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1-N607R

<400>  32
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttcaaa      540

gggttccacg agaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgcg tggctgggat aaaaataagg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  33
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1-K613R

<400>  33
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttcaaa      540

gggttccacg agaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgaa cggctgggat aaaaatcgtg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  34
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1-E184R-N607R

<400>  34
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttcaaa      540

gggttccacc gtaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgcg tggctgggat aaaaataagg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  35
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1-E184R-N607R-K613R

<400>  35
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttcaaa      540

gggttccacc gtaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgcg tggctgggat aaaaatcgtg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  36
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1-T148R

<400>  36
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt ccgtactgcc tttacgggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgggtggat gggataagga caaagagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  37
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1-T152R

<400>  37
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt cacgactgcc tttcgtggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgggtggat gggataagga caaagagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  38
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1-G532R

<400>  38
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt cacgactgcc tttacgggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgcgtggat gggataagga caaagagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  39
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1-K538R

<400>  39
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt cacgactgcc tttacgggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgggtggat gggataagga ccgtgagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  40
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1-T152R-G532R

<400>  40
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt cacgactgcc tttcgtggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgcgtggat gggataagga caaagagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  41
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1-T152R-G532R-K538R

<400>  41
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt cacgactgcc tttcgtggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgcgtggat gggataagga ccgtgagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  42
<211>  3687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LbCpf1-K536R

<400>  42
atgtctaagc tggaaaaatt caccaactgc tacagtttaa gcaagacgtt acgcttcaag       60

gcgatcccgg ttgggaaaac acaagagaat attgacaaca aacgcctttt agttgaagat      120

gagaagcgtg cagaggacta taaaggagtt aagaagcttt tggaccgtta ctacttatcg      180

tttattaatg atgtgctgca ttccatcaaa ctgaagaatc tgaataatta cattagtctt      240

ttccgtaaga aaacacgtac tgagaaggaa aacaaggagc tggaaaatct tgagatcaat      300

ttgcgcaagg agattgctaa ggcattcaaa ggtaacgagg gatataagtc gttgtttaaa      360

aaagacatta ttgaaacgat ccttccggaa ttccttgacg ataaagacga gattgcactg      420

gtgaactcct tcaacgggtt cacgactgcc tttacgggtt tttttgacaa ccgcgagaat      480

atgttcagtg aagaagccaa atctacctct atcgctttcc gctgcattaa tgaaaacctg      540

actcgttata tctctaacat ggacatcttc gaaaaggtag acgcgatctt tgataaacac      600

gaagtgcagg agatcaagga gaaaattctt aatagcgact atgatgttga agatttcttt      660

gagggggaat tctttaactt tgtactgacg caagaaggga tcgacgtcta taacgctatt      720

atcggaggat tcgtaaccga gagtggagag aaaattaagg gtcttaatga gtacattaat      780

ttgtacaatc aaaaaacgaa acagaaattg cccaagttta aacctctgta taaacaagtg      840

ctgagtgatc gcgaaagttt gtcattctat ggagaggggt atactagcga cgaggaggtt      900

cttgaggtgt ttcgcaacac cttaaacaag aactctgaga ttttcagctc aatcaaaaaa      960

cttgagaaat tatttaaaaa tttcgacgaa tactcgtcag ccggcatttt cgtgaaaaat     1020

ggtccggcca tttccacaat ctctaaggac atctttggag aatggaacgt tatccgtgac     1080

aaatggaacg ctgaatatga tgacatccat ttgaaaaaga aggctgtcgt tacagaaaaa     1140

tatgaagatg atcgccgcaa gagcttcaaa aagatcggtt cgttctcgct tgagcagttg     1200

caagaatacg cagatgccga tctgtcagta gtagagaaat taaaggaaat cattattcaa     1260

aaagtggacg agatttacaa agtttacgga tcctctgaga agctttttga tgcagatttt     1320

gtgttggaga aatcgttaaa aaagaatgat gccgtcgtgg caattatgaa agacttatta     1380

gatagcgtga agtccttcga gaattatatt aaggcgttct ttggagaggg taaggagaca     1440

aaccgcgacg aatcgtttta cggcgatttc gtgttggcct acgacatctt gctgaaagtt     1500

gatcacattt acgacgccat ccgtaactat gtaactcaga aaccctacag taaggacaag     1560

tttaagttat actttcagaa tccgcagttc atgggtggat gggatcgcga caaagagaca     1620

gactaccgtg ctactatctt acgctacggg tcgaagtatt accttgcaat tatggataag     1680

aagtacgcaa aatgcttgca gaagatcgat aaagacgacg tcaacggaaa ttatgaaaag     1740

atcaattata aattattacc cgggcctaat aaaatgttgc ccaaagtatt tttctctaag     1800

aaatggatgg cctactacaa tccatcagaa gacattcaga agatctataa aaacggcaca     1860

ttcaaaaaag gcgatatgtt caacttgaac gattgccaca aactgattga tttctttaag     1920

gatagcatta gccgttaccc gaagtggtcc aacgcttatg actttaactt cagcgaaaca     1980

gagaagtata aagacattgc agggttctac cgtgaggtag aagaacaagg atataaagtt     2040

tctttcgaaa gtgcaagtaa gaaggaagta gataaattgg ttgaggaggg caaactgtat     2100

atgtttcaga tttacaataa ggatttctct gacaagtccc acggcacacc caatttgcat     2160

actatgtact tcaaacttct gtttgacgag aataaccatg ggcagatccg tcttagtggg     2220

ggagctgagt tatttatgcg ccgtgcgtct ttgaaaaagg aggagttagt tgttcacccg     2280

gcaaattcac ccattgccaa caaaaatcca gataacccca agaagacaac cactctttca     2340

tacgatgtgt acaaagataa gcgtttctct gaagatcaat acgaactgca tattccgatc     2400

gcaatcaaca agtgcccaaa gaacatcttt aaaatcaata cggaagttcg cgttcttctg     2460

aaacatgatg ataacccgta tgttattgga attgatcgtg gggagcgtaa cttgttgtat     2520

attgtcgtag tagatggaaa aggtaacatc gtcgaacagt actcgctgaa tgagattatt     2580

aacaacttca acgggattcg catcaagact gattaccact cacttcttga caaaaaggag     2640

aaggagcgct ttgaagcccg tcaaaattgg acatcaatcg aaaatattaa ggagctgaaa     2700

gccggataca tctctcaagt ggtccataaa atttgtgaac tggtcgagaa atatgatgcc     2760

gtgatcgcgc ttgaggacct gaatagtgga ttcaaaaact cgcgtgtgaa agttgagaaa     2820

caggtgtatc agaaatttga gaaaatgtta attgacaaat tgaactacat ggtagataaa     2880

aagagtaacc catgtgcgac gggcggtgca ttgaagggat accagatcac caataagttt     2940

gagtctttca aaagtatgtc tacgcagaat ggttttattt tctacatccc ggcttggctg     3000

acatctaaaa ttgacccttc gacgggtttt gtcaatctgc tgaaaacaaa gtatacaagt     3060

attgcggatt caaaaaaatt catctcatct ttcgatcgca tcatgtacgt cccagaagaa     3120

gacttatttg agtttgcact ggattataag aatttttccc gtactgacgc agactatatc     3180

aagaaatgga aattatattc atacgggaac cgcattcgta tcttccgtaa tcctaaaaag     3240

aacaacgttt tcgactggga agaagtatgc ttaaccagtg cttacaaaga attgttcaac     3300

aaatacggca ttaactacca gcagggcgac attcgcgcat tattatgcga acagtcagat     3360

aaagcgttct actccagctt tatggcgtta atgtcgctta tgttacagat gcgcaacagc     3420

attacaggcc gcaccgatgt cgattttctg atttcgccgg tgaaaaacag cgatggcatt     3480

ttttacgatt ctcgcaatta cgaggcgcag gaaaatgcaa ttcttccgaa gaacgcagac     3540

gcaaacggcg cttacaacat cgcacgtaaa gttctttggg cgatcggaca atttaaaaaa     3600

gccgaggatg aaaaattgga caaggttaaa attgctatct cgaataaaga gtggcttgag     3660

tacgcgcaaa cttctgttaa gcactga                                         3687


<210>  43
<211>  3903
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  FnCpf1-K611R

<400>  43
atgtctatct accaggagtt tgtaaacaag tattctctta gtaaaacgtt gcgttttgaa       60

cttattccac agggtaaaac cctggagaat attaaggctc gtggcttaat tcttgatgac      120

gaaaagcgcg caaaggatta caaaaaggca aaacaaatta ttgataagta ccatcagttc      180

ttcattgaag agattttatc cagcgtttgt atctccgagg acctgttaca gaactacagc      240

gatgtatatt tcaaattgaa aaaatccgat gatgacaatc tgcaaaagga ttttaaatcg      300

gccaaggaca ctatcaagaa acaaatttct gagtacatca aagatagcga gaaattcaag      360

aatttattta accaaaatct gatcgacgcg aagaaggggc aggagtcaga cttgattttg      420

tggttgaaac agtcgaaaga taatggaatc gaactgttca aagccaactc tgacattaca      480

gatattgatg aagctctgga aattattaag agctttaagg ggtggaccac ctatttcaaa      540

gggttccacg agaaccgtaa aaacgtgtac tcttcgaatg atattcctac tagcattatt      600

tatcgtattg tagacgacaa ccttcctaaa ttcttggaga ataaagctaa atatgaatcg      660

ctgaaggata aggcgcccga agcaatcaat tacgaacaaa tcaaaaaaga tctggctgaa      720

gaactgacct ttgacattga ctataaaact tctgaagtaa accagcgcgt tttcagtctt      780

gacgaggttt ttgaaatcgc taattttaat aattatttaa atcaatccgg gattacaaaa      840

tttaacacga ttattggtgg caagttcgta aatggagaga acactaagcg taagggaatt      900

aacgagtaca ttaatttata ctcgcagcag attaacgaca aaacgctgaa aaaatataaa      960

atgagcgttt tatttaagca aattctgagc gataccgagt caaagtcctt cgtaattgac     1020

aagcttgagg atgactctga cgttgtcacg acgatgcagt cattctatga acagattgcg     1080

gcttttaaaa ccgtggaaga aaaatcaatc aaagagacct tgtcattatt atttgacgat     1140

ctgaaagctc aaaagttgga cttaagtaag atctacttta agaatgataa gagtctgacg     1200

gatttatccc aacaagtctt tgacgactac tctgtaattg gcacagccgt cttggaatac     1260

atcacccaac aaatcgctcc taaaaattta gacaatccga gtaaaaagga acaagagctg     1320

attgcaaaaa agaccgagaa agcgaaatat ttatcgttag aaactattaa attagcgctg     1380

gaagaattta ataaacaccg tgacattgac aagcaatgtc gtttcgaaga gattttagct     1440

aactttgcgg ccatcccgat gatctttgac gagattgcac aaaataaaga caatcttgcg     1500

cagatctcga ttaagtatca gaaccaaggt aagaaagacc tgttgcaggc ttccgcagag     1560

gatgacgtta aagcgatcaa agatctgtta gaccaaacca acaatttgct tcacaagtta     1620

aagatttttc acatttcaca gtcagaggat aaagcaaaca ttcttgataa agacgaacac     1680

ttttatttag ttttcgagga atgttatttt gagctggcga acattgttcc cctttataat     1740

aagatccgta attatatcac tcagaaacct tattctgacg agaaattcaa gttgaatttt     1800

gaaaactcca ctcttgcgaa cggctgggat cgcaataagg aacccgataa tactgccatt     1860

ctgtttatta aagacgacaa atattactta ggagttatga ataagaaaaa caataagatc     1920

tttgatgaca aagctattaa ggagaacaaa ggcgagggct acaaaaaaat tgtatacaaa     1980

cttctgcctg gagctaacaa gatgttgcca aaagtatttt tcagtgcaaa atcgattaag     2040

ttctacaacc catcggagga tattttacgt attcgcaacc attccaccca tacgaaaaat     2100

gggtcacccc aaaagggtta cgaaaagttt gagtttaata ttgaagattg ccgtaagttt     2160

attgattttt ataaacaatc tatctctaaa caccccgaat ggaaggattt cggattccgt     2220

ttctctgaca cacaacgcta caattcgatc gatgaattct atcgtgaggt tgagaaccaa     2280

ggatataagt tgacatttga aaacatttcc gaatcataca tcgattcggt cgtgaaccag     2340

ggtaagttat atttatttca gatctacaac aaggattttt ccgcctatag caaaggccgt     2400

ccgaacttac atacgttgta ctggaaggcc ctgtttgatg agcgcaatct gcaagatgtc     2460

gtatataagt taaatggcga agctgaactg ttttaccgca agcagtcgat cccgaagaag     2520

atcacacatc ctgctaagga ggcaattgct aacaagaata aagacaatcc aaagaaagaa     2580

agtgtcttcg agtatgactt aattaaagat aaacgtttta ctgaggacaa gtttttcttt     2640

cattgcccaa tcacaatcaa tttcaaatca agtggagcaa acaagtttaa cgacgaaatt     2700

aacttactgc tgaaggaaaa ggcgaatgac gtgcacattc tgtccattga tcgcggagaa     2760

cgtcacctgg cgtactatac gttggtcgac gggaagggaa acatcattaa acaggacacg     2820

tttaatatta tcggcaatga tcgcatgaag acaaattatc acgacaagct ggcggcaatt     2880

gagaaggatc gtgactcagc tcgcaaagac tggaagaaga ttaacaacat caaggagatg     2940

aaagagggtt atcttagcca agtcgtccat gagattgcaa aattggttat tgaatacaat     3000

gcgattgttg tcttcgaaga tcttaatttt gggttcaaac gtggtcgctt caaagtcgag     3060

aagcaggttt accaaaagct ggaaaagatg cttattgaga aattgaatta cttggttttc     3120

aaggacaatg aattcgataa gacaggcggt gtacttcgtg cgtatcaact tacggcaccc     3180

tttgaaacct tcaaaaaaat gggcaaacaa actgggatca tctactacgt gccggcgggg     3240

ttcaccagca aaatttgtcc tgtaactggg ttcgtgaacc agttgtaccc caaatacgaa     3300

tcagtcagta agtcccagga gtttttttct aagttcgata agatctgtta taatcttgac     3360

aaaggctact ttgagttttc tttcgattat aagaactttg gcgataaagc agccaaaggg     3420

aagtggacta ttgcgtcgtt cggctcacgt cttatcaact ttcgcaacag cgataagaac     3480

cataactggg atacacgtga agtttatcca acgaaggagc ttgagaagtt attaaaagat     3540

tacagtattg aatatgggca cggggagtgc attaaagcag ctatctgtgg tgagtcggac     3600

aagaaattct tcgcaaaact gacgtctgtt cttaatacca tccttcaaat gcgtaattcc     3660

aagacgggta cggagctgga ttacctgatc agtcccgttg ccgatgttaa tggtaatttt     3720

ttcgactcgc gtcaggcccc gaagaacatg cctcaggacg ccgatgccaa cggtgcgtac     3780

catattggcc ttaagggctt aatgctgtta ggacgtatta agaacaacca ggagggtaaa     3840

aaactgaatc tggtcattaa aaacgaagaa tatttcgaat ttgtacagaa ccgcaataac     3900

tga                                                                   3903


<210>  44
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E- RPA-F

<400>  44
tgtactcatt cgtttcggaa gagacaggta cg                                     32


<210>  45
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Cov2-E- RPA-R

<400>  45
tagaccagaa gatcaggaac tctagaagaa ttcag                                  35


<210>  46
<211>  308
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2-E

<400>  46
taatacgact cactataggg agatctagaa ataattttgt ttaactttaa gaaggagata       60

taccatgatg tactcattcg tttcggaaga gacaggtacg ttaatagtta atagcgtact      120

tctttttctt gctttcgtgg tattcttgct agttacacta gccatcctta ctgcgcttcg      180

attgtgtgcg tactgctgca atattgttaa cgtgagtctt gtaaaacctt ctttttacgt      240

ttactctcgt gttaaaaatc tgaattcttc tagagttcct gatcttctgg tctaattttt      300

ttgaattc                                                               308


<210>  47
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E-Cr1

<400>  47
uaauuucuac uaaguguaga uacaagacuc acguuaacaa uauu                        44


<210>  48
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E-Cr2

<400>  48
uaauuucuac uaaguguaga uacacgagag uaaacguaaa aaga                        44


<210>  49
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E-Cr3

<400>  49
uaauuucuac uaaguguaga uaacacgaga guaaacguaa aaag                        44


<210>  50
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E-Cr4

<400>  50
uaauuucuac uaaguguaga uuacguuuac ucucguguua aaaa                        44


<210>  51
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E-Cr5

<400>  51
uaauuucuac uaaguguaga uuaacacgag aguaaacgua aaaa                        44


<210>  52
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E-Cr6

<400>  52
uaauuucuac uaaguguaga uacguuuacu cucguguuaa aaau                        44


<210>  53
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-E-Cr7

<400>  53
uaauuucuac uaaguguaga ucguuuacuc ucguguuaaa aauc                        44


<210>  54
<211>  1228
<212>  PRT
<213>  Lachnospiraceae bacterium ND2006

<400>  54

Met Ser Lys Leu Glu Lys Phe Thr Asn Cys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Lys Ala Ile Pro Val Gly Lys Thr Gln Glu Asn Ile Asp 
            20                  25                  30          


Asn Lys Arg Leu Leu Val Glu Asp Glu Lys Arg Ala Glu Asp Tyr Lys 
        35                  40                  45              


Gly Val Lys Lys Leu Leu Asp Arg Tyr Tyr Leu Ser Phe Ile Asn Asp 
    50                  55                  60                  


Val Leu His Ser Ile Lys Leu Lys Asn Leu Asn Asn Tyr Ile Ser Leu 
65                  70                  75                  80  


Phe Arg Lys Lys Thr Arg Thr Glu Lys Glu Asn Lys Glu Leu Glu Asn 
                85                  90                  95      


Leu Glu Ile Asn Leu Arg Lys Glu Ile Ala Lys Ala Phe Lys Gly Asn 
            100                 105                 110         


Glu Gly Tyr Lys Ser Leu Phe Lys Lys Asp Ile Ile Glu Thr Ile Leu 
        115                 120                 125             


Pro Glu Phe Leu Asp Asp Lys Asp Glu Ile Ala Leu Val Asn Ser Phe 
    130                 135                 140                 


Asn Gly Phe Thr Thr Ala Phe Thr Gly Phe Phe Asp Asn Arg Glu Asn 
145                 150                 155                 160 


Met Phe Ser Glu Glu Ala Lys Ser Thr Ser Ile Ala Phe Arg Cys Ile 
                165                 170                 175     


Asn Glu Asn Leu Thr Arg Tyr Ile Ser Asn Met Asp Ile Phe Glu Lys 
            180                 185                 190         


Val Asp Ala Ile Phe Asp Lys His Glu Val Gln Glu Ile Lys Glu Lys 
        195                 200                 205             


Ile Leu Asn Ser Asp Tyr Asp Val Glu Asp Phe Phe Glu Gly Glu Phe 
    210                 215                 220                 


Phe Asn Phe Val Leu Thr Gln Glu Gly Ile Asp Val Tyr Asn Ala Ile 
225                 230                 235                 240 


Ile Gly Gly Phe Val Thr Glu Ser Gly Glu Lys Ile Lys Gly Leu Asn 
                245                 250                 255     


Glu Tyr Ile Asn Leu Tyr Asn Gln Lys Thr Lys Gln Lys Leu Pro Lys 
            260                 265                 270         


Phe Lys Pro Leu Tyr Lys Gln Val Leu Ser Asp Arg Glu Ser Leu Ser 
        275                 280                 285             


Phe Tyr Gly Glu Gly Tyr Thr Ser Asp Glu Glu Val Leu Glu Val Phe 
    290                 295                 300                 


Arg Asn Thr Leu Asn Lys Asn Ser Glu Ile Phe Ser Ser Ile Lys Lys 
305                 310                 315                 320 


Leu Glu Lys Leu Phe Lys Asn Phe Asp Glu Tyr Ser Ser Ala Gly Ile 
                325                 330                 335     


Phe Val Lys Asn Gly Pro Ala Ile Ser Thr Ile Ser Lys Asp Ile Phe 
            340                 345                 350         


Gly Glu Trp Asn Val Ile Arg Asp Lys Trp Asn Ala Glu Tyr Asp Asp 
        355                 360                 365             


Ile His Leu Lys Lys Lys Ala Val Val Thr Glu Lys Tyr Glu Asp Asp 
    370                 375                 380                 


Arg Arg Lys Ser Phe Lys Lys Ile Gly Ser Phe Ser Leu Glu Gln Leu 
385                 390                 395                 400 


Gln Glu Tyr Ala Asp Ala Asp Leu Ser Val Val Glu Lys Leu Lys Glu 
                405                 410                 415     


Ile Ile Ile Gln Lys Val Asp Glu Ile Tyr Lys Val Tyr Gly Ser Ser 
            420                 425                 430         


Glu Lys Leu Phe Asp Ala Asp Phe Val Leu Glu Lys Ser Leu Lys Lys 
        435                 440                 445             


Asn Asp Ala Val Val Ala Ile Met Lys Asp Leu Leu Asp Ser Val Lys 
    450                 455                 460                 


Ser Phe Glu Asn Tyr Ile Lys Ala Phe Phe Gly Glu Gly Lys Glu Thr 
465                 470                 475                 480 


Asn Arg Asp Glu Ser Phe Tyr Gly Asp Phe Val Leu Ala Tyr Asp Ile 
                485                 490                 495     


Leu Leu Lys Val Asp His Ile Tyr Asp Ala Ile Arg Asn Tyr Val Thr 
            500                 505                 510         


Gln Lys Pro Tyr Ser Lys Asp Lys Phe Lys Leu Tyr Phe Gln Asn Pro 
        515                 520                 525             


Gln Phe Met Gly Gly Trp Asp Lys Asp Lys Glu Thr Asp Tyr Arg Ala 
    530                 535                 540                 


Thr Ile Leu Arg Tyr Gly Ser Lys Tyr Tyr Leu Ala Ile Met Asp Lys 
545                 550                 555                 560 


Lys Tyr Ala Lys Cys Leu Gln Lys Ile Asp Lys Asp Asp Val Asn Gly 
                565                 570                 575     


Asn Tyr Glu Lys Ile Asn Tyr Lys Leu Leu Pro Gly Pro Asn Lys Met 
            580                 585                 590         


Leu Pro Lys Val Phe Phe Ser Lys Lys Trp Met Ala Tyr Tyr Asn Pro 
        595                 600                 605             


Ser Glu Asp Ile Gln Lys Ile Tyr Lys Asn Gly Thr Phe Lys Lys Gly 
    610                 615                 620                 


Asp Met Phe Asn Leu Asn Asp Cys His Lys Leu Ile Asp Phe Phe Lys 
625                 630                 635                 640 


Asp Ser Ile Ser Arg Tyr Pro Lys Trp Ser Asn Ala Tyr Asp Phe Asn 
                645                 650                 655     


Phe Ser Glu Thr Glu Lys Tyr Lys Asp Ile Ala Gly Phe Tyr Arg Glu 
            660                 665                 670         


Val Glu Glu Gln Gly Tyr Lys Val Ser Phe Glu Ser Ala Ser Lys Lys 
        675                 680                 685             


Glu Val Asp Lys Leu Val Glu Glu Gly Lys Leu Tyr Met Phe Gln Ile 
    690                 695                 700                 


Tyr Asn Lys Asp Phe Ser Asp Lys Ser His Gly Thr Pro Asn Leu His 
705                 710                 715                 720 


Thr Met Tyr Phe Lys Leu Leu Phe Asp Glu Asn Asn His Gly Gln Ile 
                725                 730                 735     


Arg Leu Ser Gly Gly Ala Glu Leu Phe Met Arg Arg Ala Ser Leu Lys 
            740                 745                 750         


Lys Glu Glu Leu Val Val His Pro Ala Asn Ser Pro Ile Ala Asn Lys 
        755                 760                 765             


Asn Pro Asp Asn Pro Lys Lys Thr Thr Thr Leu Ser Tyr Asp Val Tyr 
    770                 775                 780                 


Lys Asp Lys Arg Phe Ser Glu Asp Gln Tyr Glu Leu His Ile Pro Ile 
785                 790                 795                 800 


Ala Ile Asn Lys Cys Pro Lys Asn Ile Phe Lys Ile Asn Thr Glu Val 
                805                 810                 815     


Arg Val Leu Leu Lys His Asp Asp Asn Pro Tyr Val Ile Gly Ile Asp 
            820                 825                 830         


Arg Gly Glu Arg Asn Leu Leu Tyr Ile Val Val Val Asp Gly Lys Gly 
        835                 840                 845             


Asn Ile Val Glu Gln Tyr Ser Leu Asn Glu Ile Ile Asn Asn Phe Asn 
    850                 855                 860                 


Gly Ile Arg Ile Lys Thr Asp Tyr His Ser Leu Leu Asp Lys Lys Glu 
865                 870                 875                 880 


Lys Glu Arg Phe Glu Ala Arg Gln Asn Trp Thr Ser Ile Glu Asn Ile 
                885                 890                 895     


Lys Glu Leu Lys Ala Gly Tyr Ile Ser Gln Val Val His Lys Ile Cys 
            900                 905                 910         


Glu Leu Val Glu Lys Tyr Asp Ala Val Ile Ala Leu Glu Asp Leu Asn 
        915                 920                 925             


Ser Gly Phe Lys Asn Ser Arg Val Lys Val Glu Lys Gln Val Tyr Gln 
    930                 935                 940                 


Lys Phe Glu Lys Met Leu Ile Asp Lys Leu Asn Tyr Met Val Asp Lys 
945                 950                 955                 960 


Lys Ser Asn Pro Cys Ala Thr Gly Gly Ala Leu Lys Gly Tyr Gln Ile 
                965                 970                 975     


Thr Asn Lys Phe Glu Ser Phe Lys Ser Met Ser Thr Gln Asn Gly Phe 
            980                 985                 990         


Ile Phe Tyr Ile Pro Ala Trp Leu  Thr Ser Lys Ile Asp  Pro Ser Thr 
        995                 1000                 1005             


Gly Phe  Val Asn Leu Leu Lys  Thr Lys Tyr Thr Ser  Ile Ala Asp 
    1010                 1015                 1020             


Ser Lys  Lys Phe Ile Ser Ser  Phe Asp Arg Ile Met  Tyr Val Pro 
    1025                 1030                 1035             


Glu Glu  Asp Leu Phe Glu Phe  Ala Leu Asp Tyr Lys  Asn Phe Ser 
    1040                 1045                 1050             


Arg Thr  Asp Ala Asp Tyr Ile  Lys Lys Trp Lys Leu  Tyr Ser Tyr 
    1055                 1060                 1065             


Gly Asn  Arg Ile Arg Ile Phe  Arg Asn Pro Lys Lys  Asn Asn Val 
    1070                 1075                 1080             


Phe Asp  Trp Glu Glu Val Cys  Leu Thr Ser Ala Tyr  Lys Glu Leu 
    1085                 1090                 1095             


Phe Asn  Lys Tyr Gly Ile Asn  Tyr Gln Gln Gly Asp  Ile Arg Ala 
    1100                 1105                 1110             


Leu Leu  Cys Glu Gln Ser Asp  Lys Ala Phe Tyr Ser  Ser Phe Met 
    1115                 1120                 1125             


Ala Leu  Met Ser Leu Met Leu  Gln Met Arg Asn Ser  Ile Thr Gly 
    1130                 1135                 1140             


Arg Thr  Asp Val Asp Phe Leu  Ile Ser Pro Val Lys  Asn Ser Asp 
    1145                 1150                 1155             


Gly Ile  Phe Tyr Asp Ser Arg  Asn Tyr Glu Ala Gln  Glu Asn Ala 
    1160                 1165                 1170             


Ile Leu  Pro Lys Asn Ala Asp  Ala Asn Gly Ala Tyr  Asn Ile Ala 
    1175                 1180                 1185             


Arg Lys  Val Leu Trp Ala Ile  Gly Gln Phe Lys Lys  Ala Glu Asp 
    1190                 1195                 1200             


Glu Lys  Leu Asp Lys Val Lys  Ile Ala Ile Ser Asn  Lys Glu Trp 
    1205                 1210                 1215             


Leu Glu  Tyr Ala Gln Thr Ser  Val Lys His 
    1220                 1225             


<210>  55
<211>  1300
<212>  PRT
<213>  Francisella novicida U112

<400>  55

Met Ser Ile Tyr Gln Glu Phe Val Asn Lys Tyr Ser Leu Ser Lys Thr 
1               5                   10                  15      


Leu Arg Phe Glu Leu Ile Pro Gln Gly Lys Thr Leu Glu Asn Ile Lys 
            20                  25                  30          


Ala Arg Gly Leu Ile Leu Asp Asp Glu Lys Arg Ala Lys Asp Tyr Lys 
        35                  40                  45              


Lys Ala Lys Gln Ile Ile Asp Lys Tyr His Gln Phe Phe Ile Glu Glu 
    50                  55                  60                  


Ile Leu Ser Ser Val Cys Ile Ser Glu Asp Leu Leu Gln Asn Tyr Ser 
65                  70                  75                  80  


Asp Val Tyr Phe Lys Leu Lys Lys Ser Asp Asp Asp Asn Leu Gln Lys 
                85                  90                  95      


Asp Phe Lys Ser Ala Lys Asp Thr Ile Lys Lys Gln Ile Ser Glu Tyr 
            100                 105                 110         


Ile Lys Asp Ser Glu Lys Phe Lys Asn Leu Phe Asn Gln Asn Leu Ile 
        115                 120                 125             


Asp Ala Lys Lys Gly Gln Glu Ser Asp Leu Ile Leu Trp Leu Lys Gln 
    130                 135                 140                 


Ser Lys Asp Asn Gly Ile Glu Leu Phe Lys Ala Asn Ser Asp Ile Thr 
145                 150                 155                 160 


Asp Ile Asp Glu Ala Leu Glu Ile Ile Lys Ser Phe Lys Gly Trp Thr 
                165                 170                 175     


Thr Tyr Phe Lys Gly Phe His Glu Asn Arg Lys Asn Val Tyr Ser Ser 
            180                 185                 190         


Asn Asp Ile Pro Thr Ser Ile Ile Tyr Arg Ile Val Asp Asp Asn Leu 
        195                 200                 205             


Pro Lys Phe Leu Glu Asn Lys Ala Lys Tyr Glu Ser Leu Lys Asp Lys 
    210                 215                 220                 


Ala Pro Glu Ala Ile Asn Tyr Glu Gln Ile Lys Lys Asp Leu Ala Glu 
225                 230                 235                 240 


Glu Leu Thr Phe Asp Ile Asp Tyr Lys Thr Ser Glu Val Asn Gln Arg 
                245                 250                 255     


Val Phe Ser Leu Asp Glu Val Phe Glu Ile Ala Asn Phe Asn Asn Tyr 
            260                 265                 270         


Leu Asn Gln Ser Gly Ile Thr Lys Phe Asn Thr Ile Ile Gly Gly Lys 
        275                 280                 285             


Phe Val Asn Gly Glu Asn Thr Lys Arg Lys Gly Ile Asn Glu Tyr Ile 
    290                 295                 300                 


Asn Leu Tyr Ser Gln Gln Ile Asn Asp Lys Thr Leu Lys Lys Tyr Lys 
305                 310                 315                 320 


Met Ser Val Leu Phe Lys Gln Ile Leu Ser Asp Thr Glu Ser Lys Ser 
                325                 330                 335     


Phe Val Ile Asp Lys Leu Glu Asp Asp Ser Asp Val Val Thr Thr Met 
            340                 345                 350         


Gln Ser Phe Tyr Glu Gln Ile Ala Ala Phe Lys Thr Val Glu Glu Lys 
        355                 360                 365             


Ser Ile Lys Glu Thr Leu Ser Leu Leu Phe Asp Asp Leu Lys Ala Gln 
    370                 375                 380                 


Lys Leu Asp Leu Ser Lys Ile Tyr Phe Lys Asn Asp Lys Ser Leu Thr 
385                 390                 395                 400 


Asp Leu Ser Gln Gln Val Phe Asp Asp Tyr Ser Val Ile Gly Thr Ala 
                405                 410                 415     


Val Leu Glu Tyr Ile Thr Gln Gln Ile Ala Pro Lys Asn Leu Asp Asn 
            420                 425                 430         


Pro Ser Lys Lys Glu Gln Glu Leu Ile Ala Lys Lys Thr Glu Lys Ala 
        435                 440                 445             


Lys Tyr Leu Ser Leu Glu Thr Ile Lys Leu Ala Leu Glu Glu Phe Asn 
    450                 455                 460                 


Lys His Arg Asp Ile Asp Lys Gln Cys Arg Phe Glu Glu Ile Leu Ala 
465                 470                 475                 480 


Asn Phe Ala Ala Ile Pro Met Ile Phe Asp Glu Ile Ala Gln Asn Lys 
                485                 490                 495     


Asp Asn Leu Ala Gln Ile Ser Ile Lys Tyr Gln Asn Gln Gly Lys Lys 
            500                 505                 510         


Asp Leu Leu Gln Ala Ser Ala Glu Asp Asp Val Lys Ala Ile Lys Asp 
        515                 520                 525             


Leu Leu Asp Gln Thr Asn Asn Leu Leu His Lys Leu Lys Ile Phe His 
    530                 535                 540                 


Ile Ser Gln Ser Glu Asp Lys Ala Asn Ile Leu Asp Lys Asp Glu His 
545                 550                 555                 560 


Phe Tyr Leu Val Phe Glu Glu Cys Tyr Phe Glu Leu Ala Asn Ile Val 
                565                 570                 575     


Pro Leu Tyr Asn Lys Ile Arg Asn Tyr Ile Thr Gln Lys Pro Tyr Ser 
            580                 585                 590         


Asp Glu Lys Phe Lys Leu Asn Phe Glu Asn Ser Thr Leu Ala Asn Gly 
        595                 600                 605             


Trp Asp Lys Asn Lys Glu Pro Asp Asn Thr Ala Ile Leu Phe Ile Lys 
    610                 615                 620                 


Asp Asp Lys Tyr Tyr Leu Gly Val Met Asn Lys Lys Asn Asn Lys Ile 
625                 630                 635                 640 


Phe Asp Asp Lys Ala Ile Lys Glu Asn Lys Gly Glu Gly Tyr Lys Lys 
                645                 650                 655     


Ile Val Tyr Lys Leu Leu Pro Gly Ala Asn Lys Met Leu Pro Lys Val 
            660                 665                 670         


Phe Phe Ser Ala Lys Ser Ile Lys Phe Tyr Asn Pro Ser Glu Asp Ile 
        675                 680                 685             


Leu Arg Ile Arg Asn His Ser Thr His Thr Lys Asn Gly Ser Pro Gln 
    690                 695                 700                 


Lys Gly Tyr Glu Lys Phe Glu Phe Asn Ile Glu Asp Cys Arg Lys Phe 
705                 710                 715                 720 


Ile Asp Phe Tyr Lys Gln Ser Ile Ser Lys His Pro Glu Trp Lys Asp 
                725                 730                 735     


Phe Gly Phe Arg Phe Ser Asp Thr Gln Arg Tyr Asn Ser Ile Asp Glu 
            740                 745                 750         


Phe Tyr Arg Glu Val Glu Asn Gln Gly Tyr Lys Leu Thr Phe Glu Asn 
        755                 760                 765             


Ile Ser Glu Ser Tyr Ile Asp Ser Val Val Asn Gln Gly Lys Leu Tyr 
    770                 775                 780                 


Leu Phe Gln Ile Tyr Asn Lys Asp Phe Ser Ala Tyr Ser Lys Gly Arg 
785                 790                 795                 800 


Pro Asn Leu His Thr Leu Tyr Trp Lys Ala Leu Phe Asp Glu Arg Asn 
                805                 810                 815     


Leu Gln Asp Val Val Tyr Lys Leu Asn Gly Glu Ala Glu Leu Phe Tyr 
            820                 825                 830         


Arg Lys Gln Ser Ile Pro Lys Lys Ile Thr His Pro Ala Lys Glu Ala 
        835                 840                 845             


Ile Ala Asn Lys Asn Lys Asp Asn Pro Lys Lys Glu Ser Val Phe Glu 
    850                 855                 860                 


Tyr Asp Leu Ile Lys Asp Lys Arg Phe Thr Glu Asp Lys Phe Phe Phe 
865                 870                 875                 880 


His Cys Pro Ile Thr Ile Asn Phe Lys Ser Ser Gly Ala Asn Lys Phe 
                885                 890                 895     


Asn Asp Glu Ile Asn Leu Leu Leu Lys Glu Lys Ala Asn Asp Val His 
            900                 905                 910         


Ile Leu Ser Ile Asp Arg Gly Glu Arg His Leu Ala Tyr Tyr Thr Leu 
        915                 920                 925             


Val Asp Gly Lys Gly Asn Ile Ile Lys Gln Asp Thr Phe Asn Ile Ile 
    930                 935                 940                 


Gly Asn Asp Arg Met Lys Thr Asn Tyr His Asp Lys Leu Ala Ala Ile 
945                 950                 955                 960 


Glu Lys Asp Arg Asp Ser Ala Arg Lys Asp Trp Lys Lys Ile Asn Asn 
                965                 970                 975     


Ile Lys Glu Met Lys Glu Gly Tyr Leu Ser Gln Val Val His Glu Ile 
            980                 985                 990         


Ala Lys Leu Val Ile Glu Tyr Asn  Ala Ile Val Val Phe  Glu Asp Leu 
        995                 1000                 1005             


Asn Phe  Gly Phe Lys Arg Gly  Arg Phe Lys Val Glu  Lys Gln Val 
    1010                 1015                 1020             


Tyr Gln  Lys Leu Glu Lys Met  Leu Ile Glu Lys Leu  Asn Tyr Leu 
    1025                 1030                 1035             


Val Phe  Lys Asp Asn Glu Phe  Asp Lys Thr Gly Gly  Val Leu Arg 
    1040                 1045                 1050             


Ala Tyr  Gln Leu Thr Ala Pro  Phe Glu Thr Phe Lys  Lys Met Gly 
    1055                 1060                 1065             


Lys Gln  Thr Gly Ile Ile Tyr  Tyr Val Pro Ala Gly  Phe Thr Ser 
    1070                 1075                 1080             


Lys Ile  Cys Pro Val Thr Gly  Phe Val Asn Gln Leu  Tyr Pro Lys 
    1085                 1090                 1095             


Tyr Glu  Ser Val Ser Lys Ser  Gln Glu Phe Phe Ser  Lys Phe Asp 
    1100                 1105                 1110             


Lys Ile  Cys Tyr Asn Leu Asp  Lys Gly Tyr Phe Glu  Phe Ser Phe 
    1115                 1120                 1125             


Asp Tyr  Lys Asn Phe Gly Asp  Lys Ala Ala Lys Gly  Lys Trp Thr 
    1130                 1135                 1140             


Ile Ala  Ser Phe Gly Ser Arg  Leu Ile Asn Phe Arg  Asn Ser Asp 
    1145                 1150                 1155             


Lys Asn  His Asn Trp Asp Thr  Arg Glu Val Tyr Pro  Thr Lys Glu 
    1160                 1165                 1170             


Leu Glu  Lys Leu Leu Lys Asp  Tyr Ser Ile Glu Tyr  Gly His Gly 
    1175                 1180                 1185             


Glu Cys  Ile Lys Ala Ala Ile  Cys Gly Glu Ser Asp  Lys Lys Phe 
    1190                 1195                 1200             


Phe Ala  Lys Leu Thr Ser Val  Leu Asn Thr Ile Leu  Gln Met Arg 
    1205                 1210                 1215             


Asn Ser  Lys Thr Gly Thr Glu  Leu Asp Tyr Leu Ile  Ser Pro Val 
    1220                 1225                 1230             


Ala Asp  Val Asn Gly Asn Phe  Phe Asp Ser Arg Gln  Ala Pro Lys 
    1235                 1240                 1245             


Asn Met  Pro Gln Asp Ala Asp  Ala Asn Gly Ala Tyr  His Ile Gly 
    1250                 1255                 1260             


Leu Lys  Gly Leu Met Leu Leu  Gly Arg Ile Lys Asn  Asn Gln Glu 
    1265                 1270                 1275             


Gly Lys  Lys Leu Asn Leu Val  Ile Lys Asn Glu Glu  Tyr Phe Glu 
    1280                 1285                 1290             


Phe Val  Gln Asn Arg Asn Asn  
    1295                 1300 


<210>  56
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr3

<400>  56
uaauuucuac uaaguguaga uacaagacuc acguuaacaa uauu                        44


<210>  57
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr4

<400>  57
uaauuucuac uaaguguaga uacacgagag uaaacguaaa aaga                        44


<210>  58
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr5

<400>  58
uaauuucuac uaaguguaga uaacacgaga guaaacguaa aaag                        44


<210>  59
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr6

<400>  59
uaauuucuac uaaguguaga uuacguuuac ucucguguua aaaa                        44


<210>  60
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr7

<400>  60
uaauuucuac uaaguguaga uuaacacgag aguaaacgua aaaa                        44


<210>  61
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr8

<400>  61
uaauuucuac uaaguguaga uacguuuacu cucguguuaa aaau                        44


<210>  62
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr9

<400>  62
uaauuucuac uaaguguaga ucguuuacuc ucguguuaaa aauc                        44


<210>  63
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S-cr10

<400>  63
uaauuucuac uaaguguaga uacuccuggu gauucuucuu cagg                        44


<210>  64
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-M-cr1

<400>  64
uaauuucuac uaaguguaga uuagaagcgg ucuggucaga auag                        44


<210>  65
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-M-cr2

<400>  65
uaauuucuac uaaguguaga uggcaggucc uugaugucac agcg                        44


<210>  66
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-M-cr3

<400>  66
uaauuucuac uaaguguaga uuuuaggcag guccuugaug ucac                        44


<210>  67
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-M-cr4

<400>  67
uaauuucuac uaaguguaga uuaauaagaa agcguucgug augu                        44


<210>  68
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-M-cr5

<400>  68
uaauuucuac uaaguguaga uuuauuacaa auugggagcu ucgc                        44


<210>  69
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-N-cr1

<400>  69
uaauuucuac uaaguguaga uuugaacugu ugcgacuacg ugau                        44


<210>  70
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-N-cr2

<400>  70
uaauuucuac uaaguguaga ucugcugcuu gacagauuga acca                        44


<210>  71
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-N-cr3

<400>  71
uaauuucuac uaaguguaga ucucucaagc ugguucaauc uguc                        44


<210>  72
<211>  44
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  CoV2-N-cr4

<400>  72
uaauuucuac uaaguguaga ugccuuguug uuguuggccu uuac                        44


<210>  73
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S- RPA-F

<400>  73
ggaaagtgag ttcagagttt attctagtgc ga                                     32


<210>  74
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoV2-S- RPA-R

<400>  74
cacagtctac agcatctgta atggttccat                                        30


<210>  75
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoV2-M- RPA-F

<400>  75
ctacttcatt gcttctttca gactgtttgc                                        30


<210>  76
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoV2-M- RPA-R

<400>  76
ttatagttgc caatcctgta gcgactgtat                                        30


<210>  77
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoV2-N- RPA-F

<400>  77
atcgtgctac aacttcctca aggaacaaca                                        30


<210>  78
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CoV2-N- RPA-R

<400>  78
gcaatttgcg gccaatgttt gtaatcagtt                                        30


<210>  79
<211>  416
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2-S-

<400>  79
ggaaagtgag ttcagagttt attctagtgc gaataattgc acttttgaat atgtctctca       60

gccttttctt atggaccttg aaggaaaaca gggtaatttc aaaaatctta gggaatttgt      120

gtttaagaat attgatggtt attttaaaat atattctaag cacacgccta ttaatttagt      180

gcgtgatctc cctcagggtt tttcggcttt agaaccattg gtagatttgc caataggtat      240

taacatcact aggtttcaaa ctttacttgc tttacataga agttatttga ctcctggtga      300

ttcttcttca ggttggacag ctggtgctgc agcttattat gtgggttatc ttcaacctag      360

gacttttcta ttaaaatata atgaaaatgg aaccattaca gatgctgtag actgtg          416


<210>  80
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2-M-

<400>  80
ctacttcatt gcttctttca gactgtttgc gcgtacgcgt tccatgtggt cattcaatcc       60

agaaactaac attcttctca acgtgccact ccatggcact attctgacca gaccgcttct      120

agaaagtgaa ctcgtaatcg gagctgtgat ccttcgtgga catcttcgta ttgctggaca      180

ccatctagga cgctgtgaca tcaaggacct gcctaaagaa atcactgttg ctacatcacg      240

aacgctttct tattacaaat tgggagcttc gcagcgtgta gcaggtgact caggttttgc      300

tgcatacagt cgctacagga ttggcaacta taa                                   333


<210>  81
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SARS-CoV2-N-

<400>  81
atcgtgctac aacttcctca aggaacaaca ttgccaaaag gcttctacgc agaagggagc       60

agaggcggca gtcaagcctc ttctcgttcc tcatcacgta gtcgcaacag ttcaagaaat      120

tcaactccag gcagcagtag gggaacttct cctgctagaa tggctggcaa tggcggtgat      180

gctgctcttg ctttgctgct gcttgacaga ttgaaccagc ttgagagcaa aatgtctggt      240

aaaggccaac aacaacaagg ccaaactgtc actaagaaat ctgctgctga ggcttctaag      300

aagcctcggc aaaaacgtac tgccactaaa gcatacaatg taacacaagc tttcggcaga      360

cgtggtccag aacaaaccca aggaaatttt ggggaccagg aactaatcag acaaggaact      420

gattacaaac attggccgca aattgc                                           446


