                         SEQUENCE LISTING

<110>  Biocytogen PharmaceuticalsBeijingCo., Ltd
 
<120>  GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC 
       CD276

<130>  1

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  3197
<212>  DNA
<213>  Mus musculus

<400>  1
cggcgcggcg cgccaaagtg acctggtaca gcctggaccc caagctcatc ggctttgtct       60

ggctggccgc ctggcctctt cccacttgga tttggatgat cctgaggcct ttggaggaac      120

ttcgagacaa aggcccctct tcctcttcca cgggcaggag cagccattcg ccacggagag      180

cccagctgtc agctgtctca caggaagatg cttcgaggat ggggtggccc cagtgtgggt      240

gtgtgtgtgc gcacagcact gggggtgctg tgcctctgcc tcacaggagc tgtggaagtc      300

caggtctctg aagaccccgt ggtggccctg gtggacacgg atgccaccct acgctgctcc      360

ttttccccag agcctggctt cagtctggca cagctcaacc tcatctggca gctgacagac      420

accaaacagc tggtgcacag cttcacggag ggccgggacc aaggcagtgc ctactccaac      480

cgcacagcgc tcttccctga cctgttggtg caaggcaatg cgtccttgag gctgcagcgc      540

gtccgagtaa ccgacgaggg cagctacacc tgctttgtga gcatccagga ctttgacagc      600

gctgctgtta gcctgcaggt ggccgccccc tactcgaagc ccagcatgac cctggagccc      660

aacaaggacc tacgtccagg gaacatggtg accatcacgt gctctagcta ccagggctat      720

ccggaggccg aggtgttctg gaaggatgga cagggagtgc ccttgactgg caatgtgacc      780

acatcccaga tggccaacga gcggggcttg ttcgatgttc acagcgtgct gagggtggtg      840

ctgggtgcta acggcaccta cagctgcctg gtacgcaacc cggtgttgca gcaagatgct      900

cacggctcag tcaccatcac agggcagccc ctgacattcc cccctgaggc tctgtgggta      960

accgtggggc tctctgtctg tcttgtggta ctactggtgg ccctggcttt cgtgtgctgg     1020

agaaagatca agcagagctg cgaggaggag aatgcaggtg ccgaggacca ggatggagat     1080

ggagaaggat ccaagacagc tctacggcct ctgaaaccct ctgaaaacaa agaagatgac     1140

ggacaagaaa ttgcttgatt gggagctgct gcccttccca ggtggggggc ccaccctctg     1200

gcagtgttga gcttcaatgc gagcccttcc cccaacgaat gggtttgtcc cacagatcta     1260

cccgttcgtc aaaggacgtg gtccatagac cacccacagc cttacttttc caatggactt     1320

aattcccatc atcctgcagc ctcatttctc cagtgacacg atacacgaac catcctgcgg     1380

ccttatttcc cacggacacg acacaaagat gtccctcctc ggtgttcctc cagagtcgtc     1440

tggtggcctt gtgatacggc gtgaaccttc ttccttctgc cttacgtcta atggacacac     1500

acgcaccacc cccacaccct tgctcctcca aagccatgca gactgtgtaa ctgctattat     1560

tctccaaggg gcatcctgtg cagatgaaac cctgctttat ttccctgaag acagctgcac     1620

agtgacctct tagttcttgc tcccatggcc ctgatgtatc ctagttacca gccctcaacc     1680

tcagttctga gggtgggatc ccatcgctca gcaaggcttc atcctgacct ccctgccctg     1740

atctgatctg gccctggctt ttgttgtctc gctccctgac taagtgagat ggggcactct     1800

cccgcccccg ccccccccag gtcacagata cctacctgca gctgtgcgtg ctggatcacg     1860

cacatacttg ccttgcatgg tctcctggct gccctgggct gtgcctgttc ttccatagga     1920

agcaagttct tgtctccctg gttctcaggg cccctcaggg gctcagcctt cagccctgtg     1980

cttccccatg ttgggaatct ttgttacctt tttcttcttt gtaaattaac atctgataac     2040

aaccacaggg tccaatggga ctttcacaga cctgccagct agataaataa tgacaacaga     2100

agtttattaa tattttaaga cttaggcctt ttgctgggca gcctcccaac tattctatcc     2160

tgactaatcc tggcactatg tcccaccaca tggccaggtc tacctctctg ctccactctc     2220

catccacctc catgtctgcc agcaaatctc ccgtgattca gttcttctcc cagagtccct     2280

atctctgccc agaagtacca tcttcgactt cctgcccaac tattggccgt cagctcttca     2340

ttaaagccga tcagatgtaa ttctagattg ccttaggcag gtgaggaaga aacaagtatt     2400

tgtaaaatat gagaccagca atgggccata gaaataacag caccagatcc tgccagcatt     2460

tagccctctg ttggtacaaa attaacaatt gaatatacag agacctactt ccagagtgta     2520

ccccaacaac aggcgtgagc atggtgctgg gtactagggt cctgctggaa aatcagagac     2580

cttacctaca gctgggacat gaccttgctt ccgacttacc caccacttct ggatacctca     2640

ccctcagccc acactatccc tggcctaggg cccagggtag agccagaaac atggagaaag     2700

catggcccct tgccgtacct ggagaactgg gtattttcca gagtctttat agatgtggac     2760

tggaaggcag gtggccacag ccgtgcagac ctgggtcagg tcagaaacct atgccatgct     2820

gggacctact caacagcaga agcatgaaga gggcctgagg acaagaaagg ccttcttacc     2880

atggtgctat tctggagctg ggatatatac ctggcttgtc tctgactgcc ctggcttctg     2940

gcagaacttc tgatgtcctc ctgaaggcct ctctcccacc ccagtacctg agaacctgag     3000

gataatttaa acatgggact ctggccagca cctgggagag acaggtagat ctctgatttt     3060

tgactcagcc tggtctatcg agtgagttcc aggacatctg gggctacaca gagaaaccat     3120

cttaaagact aaaaataata aacatgagac tgtaaactgg gtgtattttg ggagaaataa     3180

atgtcttttt ctttcaa                                                    3197


<210>  2
<211>  316
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Arg Gly Trp Gly Gly Pro Ser Val Gly Val Cys Val Arg Thr 
1               5                   10                  15      


Ala Leu Gly Val Leu Cys Leu Cys Leu Thr Gly Ala Val Glu Val Gln 
            20                  25                  30          


Val Ser Glu Asp Pro Val Val Ala Leu Val Asp Thr Asp Ala Thr Leu 
        35                  40                  45              


Arg Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr 
65                  70                  75                  80  


Glu Gly Arg Asp Gln Gly Ser Ala Tyr Ser Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Val Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Thr Asp Glu Gly Ser Tyr Thr Cys Phe Val Ser Ile Gln Asp 
        115                 120                 125             


Phe Asp Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asn Met 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Lys Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Arg Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Leu Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Val Val Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Asp Gly Glu Gly Ser Lys Thr Ala Leu Arg Pro Leu Lys Pro 
    290                 295                 300                 


Ser Glu Asn Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


<210>  3
<211>  3295
<212>  DNA
<213>  Homo sapiens

<400>  3
attcgggccg ggcctcgctg cggcggcgac tgagccaggc tgggccgcgt ccctgagtcc       60

cagagtcggc gcggcgcggc aggggcagcc ttccaccacg gggagcccag ctgtcagccg      120

cctcacagga agatgctgcg tcggcggggc agccctggca tgggtgtgca tgtgggtgca      180

gccctgggag cactgtggtt ctgcctcaca ggagccctgg aggtccaggt ccctgaagac      240

ccagtggtgg cactggtggg caccgatgcc accctgtgct gctccttctc ccctgagcct      300

ggcttcagcc tggcacagct caacctcatc tggcagctga cagataccaa acagctggtg      360

cacagctttg ctgagggcca ggaccagggc agcgcctatg ccaaccgcac ggccctcttc      420

ccggacctgc tggcacaggg caacgcatcc ctgaggctgc agcgcgtgcg tgtggcggac      480

gagggcagct tcacctgctt cgtgagcatc cgggatttcg gcagcgctgc cgtcagcctg      540

caggtggccg ctccctactc gaagcccagc atgaccctgg agcccaacaa ggacctgcgg      600

ccaggggaca cggtgaccat cacgtgctcc agctaccagg gctaccctga ggctgaggtg      660

ttctggcagg atgggcaggg tgtgcccctg actggcaacg tgaccacgtc gcagatggcc      720

aacgagcagg gcttgtttga tgtgcacagc atcctgcggg tggtgctggg tgcaaatggc      780

acctacagct gcctggtgcg caaccccgtg ctgcagcagg atgcgcacag ctctgtcacc      840

atcacacccc agagaagccc cacaggagcc gtggaggtcc aggtccctga ggacccggtg      900

gtggccctag tgggcaccga tgccaccctg cgctgctcct tctcccccga gcctggcttc      960

agcctggcac agctcaacct catctggcag ctgacagaca ccaaacagct ggtgcacagt     1020

ttcaccgaag gccgggacca gggcagcgcc tatgccaacc gcacggccct cttcccggac     1080

ctgctggcac aaggcaatgc atccctgagg ctgcagcgcg tgcgtgtggc ggacgagggc     1140

agcttcacct gcttcgtgag catccgggat ttcggcagcg ctgccgtcag cctgcaggtg     1200

gccgctccct actcgaagcc cagcatgacc ctggagccca acaaggacct gcggccaggg     1260

gacacggtga ccatcacgtg ctccagctac cggggctacc ctgaggctga ggtgttctgg     1320

caggatgggc agggtgtgcc cctgactggc aacgtgacca cgtcgcagat ggccaacgag     1380

cagggcttgt ttgatgtgca cagcgtcctg cgggtggtgc tgggtgcgaa tggcacctac     1440

agctgcctgg tgcgcaaccc cgtgctgcag caggatgcgc acggctctgt caccatcaca     1500

gggcagccta tgacattccc cccagaggcc ctgtgggtga ccgtggggct gtctgtctgt     1560

ctcattgcac tgctggtggc cctggctttc gtgtgctgga gaaagatcaa acagagctgt     1620

gaggaggaga atgcaggagc tgaggaccag gatggggagg gagaaggctc caagacagcc     1680

ctgcagcctc tgaaacactc tgacagcaaa gaagatgatg gacaagaaat agcctgacca     1740

tgaggaccag ggagctgcta cccctcccta cagctcctac cctctggctg caatggggct     1800

gcactgtgag ccctgccccc aacagatgca tcctgctctg acaggtgggc tccttctcca     1860

aaggatgcga tacacagacc actgtgcagc cttatttctc caatggacat gattcccaag     1920

tcatcctgct gccttttttc ttatagacac aatgaacaga ccacccacaa ccttagttct     1980

ctaagtcatc ctgcctgctg ccttatttca cagtacatac atttcttagg gacacagtac     2040

actgaccaca tcaccaccct cttcttccag tgctgcgtgg accatctggc tgcctttttt     2100

ctccaaaaga tgcaatattc agactgactg accccctgcc ttatttcacc aaagacacga     2160

tgcatagtca ccccggcctt gtttctccaa tggccgtgat acactagtga tcatgttcag     2220

ccctgcttcc acctgcatag aatcttttct tctcagacag ggacagtgcg gcctcaacat     2280

ctcctggagt ctagaagctg tttcctttcc cctccttcct cctcttgctc tagccttaat     2340

actggccttt tccctccctg ccccaagtga agacagggca ctctgcgccc accacatgca     2400

cagctgtgca tggagacctg caggtgcacg tgctggaaca cgtgtggttc ccccctggcc     2460

cagcctcctc tgcagtgccc ctctcccctg cccatcctcc ccacggaagc atgtgctggt     2520

cacactggtt ctccaggggt ctgtgatggg gcccctgggg gtcagcttct gtccctctgc     2580

cttctcacct ctttgttcct ttcttttcat gtatccattc agttgatgtt tattgagcaa     2640

ctacagatgt cagcactgtg ttaggtgctg ggggccctgc gtgggaagat aaagttcctc     2700

cctcaaggac tccccatcca gctgggagac agacaactaa ctacactgca ccctgcggtt     2760

tgcagggggc tcctgcctgg ctccctgctc cacacctcct ctgtggctca aggcttcctg     2820

gatacctcac ccccatccca cccataattc ttacccagag catggggttg gggcggaaac     2880

ctggagagag ggacatagcc cctcgccacg gctagagaat ctggtggtgt ccaaaatgtc     2940

tgtccaggtg tgggcaggtg ggcaggcacc aaggccctct ggacctttca tagcagcaga     3000

aaaggcagag cctggggcag ggcagggcca ggaatgcttt ggggacaccg aggggactgc     3060

cccccacccc caccatggtg ctattctggg gctggggcag tcttttcctg gcttgcctct     3120

ggccagctcc tggcctctgg tagagtgaga cttcagacgt tctgatgcct tccggatgtc     3180

atctctccct gccccaggaa tggaagatgt gaggacttct aatttaaatg tgggactcgg     3240

agggattttg taaactgggg gtatattttg gggaaaataa atgtctttgt aaaaa          3295


<210>  4
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Leu Arg Arg Arg Gly Ser Pro Gly Met Gly Val His Val Gly Ala 
1               5                   10                  15      


Ala Leu Gly Ala Leu Trp Phe Cys Leu Thr Gly Ala Leu Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Met Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Ile Ala Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Glu Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Gln Pro Leu Lys His Ser Asp Ser Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  5
<211>  2080
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleotide sequence of 73702275-73704354 of NCBI accession number
       NC_000015.10

<400>  5
cctgaagacc cagtggtggc actggtgggc accgatgcca ccctgtgctg ctccttctcc       60

cctgagcctg gcttcagcct ggcacagctc aacctcatct ggcagctgac agataccaaa      120

cagctggtgc acagctttgc tgagggccag gaccagggca gcgcctatgc caaccgcacg      180

gccctcttcc cggacctgct ggcacagggc aacgcatccc tgaggctgca gcgcgtgcgt      240

gtggcggacg agggcagctt cacctgcttc gtgagcatcc gggatttcgg cagcgctgcc      300

gtcagcctgc aggtggccgg tgagcaccag gagggggacg ccttcccctt agttcaccct      360

ccattccccc tgcagcccac cccctgctgc accactgctc ccagaacccc agtgctgatt      420

cctgtactca gccccatgca tccttttcgt cctctgccat tgccctgccc ttgacccctg      480

ccctctgtca cctccagctc cctactcgaa gcccagcatg accctggagc ccaacaagga      540

cctgcggcca ggggacacgg tgaccatcac gtgctccagc taccagggct accctgaggc      600

tgaggtgttc tggcaggatg ggcagggtgt gcccctgact ggcaacgtga ccacgtcgca      660

gatggccaac gagcagggct tgtttgatgt gcacagcatc ctgcgggtgg tgctgggtgc      720

aaatggcacc tacagctgcc tggtgcgcaa ccccgtgctg cagcaggatg cgcacagctc      780

tgtcaccatc acaccccaga gaagccccac aggttgcttt gcttaaatgt ccccttgggg      840

gaggggggtt ctgcttctgt cggcaggggt tgggagctcc gaatctggcc ccaccttcaa      900

tctcccagaa cagcaagttg cctcctaatg atagggagaa agataacggg gaggtgggga      960

tgttcactgg aggggttggg ggcggagaaa tcacaggcct tcttaaggct ctcctgactt     1020

caaggctctg gaagcctctg ggaagaatgg agccacatct gggtcagcag aggggtgggc     1080

gaaggaaagg agtcctgatg gcaggattca ccagggctgg agctggtgag agtcacctgc     1140

cccaggcctg gccctgggat tggtctggtc aggccaagac ccacctgctg tgattgttct     1200

cagaagattg gggagactcc atatctgaga gtcctcagac ttaatctgct tttgcatcta     1260

agaagaaaat aggaagatgg aacagggtct gggaattgat gggggaagag tttgggggac     1320

tcgggtggta gcctagagag tcccatttct cctcaccacc ctgcccctct gaccccgccc     1380

ccaggagccg tggaggtcca ggtccctgag gacccggtgg tggccctagt gggcaccgat     1440

gccaccctgc gctgctcctt ctcccccgag cctggcttca gcctggcaca gctcaacctc     1500

atctggcagc tgacagacac caaacagctg gtgcacagtt tcaccgaagg ccgggaccag     1560

ggcagcgcct atgccaaccg cacggccctc ttcccggacc tgctggcaca aggcaatgca     1620

tccctgaggc tgcagcgcgt gcgtgtggcg gacgagggca gcttcacctg cttcgtgagc     1680

atccgggatt tcggcagcgc tgccgtcagc ctgcaggtgg ccggtgagca ccaggagggc     1740

gacgccttcc ccttggttca ccctccattc cctctgcagc ccaccctctg ctgcaccact     1800

gctcccagaa ccccagtgct gattcctgta ctcagcccca tgcatccttt tcctcccctg     1860

ccattgccct gcccttgacc cctgccctct gtcacctcca gctccctact cgaagcccag     1920

catgaccctg gagcccaaca aggacctgcg gccaggggac acggtgacca tcacgtgctc     1980

cagctaccgg ggctaccctg aggctgaggt gttctggcag gatgggcagg gtgtgcccct     2040

gactggcaac gtgaccacgt cgcagatggc caacgagcag                           2080


<210>  6
<211>  4063
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5' homologous arm

<400>  6
tctatctctg gaggtggtca tggatacaaa atgttcatat tcttgctaat tactgttagg       60

tgggacgggt ggacatgggt cacatggctt gagcaggcaa cagcaagaga cacaagaagt      120

gcctgcagcc tgcctgagtc aggcacctgc aagctaaacc caggggagtc tgggaccacc      180

ctgggctagg cttggtctgt tgtaagcgat ccaactcttg ctgaggcctg acgctgaccc      240

cagccctgcc cctggtctct ttcttctctg ctgggccttg gttgtttggt acatgtgtat      300

taaactagca gatgtctctc ccagactcca catccttaca tttctgctac tcctagctag      360

ggctctgtcc tggggtttct gcacacatgc tcctaaccta acatgccttg gacaaaaggc      420

tccacatttc ctgccccaat aaccaggtct cagaaccaag tgtcttgaca gttgccttcc      480

cgtgtcctat gctctcagat actgtcactg tgatctcttc ctgccttatc actcggctgg      540

cccctttcat ctaccctgca catgctatcg aagtagccct gacaatgtgg tttctttatt      600

ccagaaccct cagtggctcc tggctacctt tagtagttga gtagacgttt caagttgaac      660

cctaagtctg tctaaagtct acccctttac tgtcccattt ctcccatcag ccaaagtgac      720

ctggtacagc ctggacccca agctcatcgg ctttgtctgg ctggccgcct ggcctcttcc      780

cacttggatt tggatgatcc tgaggccttt ggaggaactt cgagacaaag gcccctcttc      840

ctcttccacg ggcaggagca gccattcgcc acggagagcc cagctgtcag ctgtctcaca      900

ggaagatgct tcgaggatgg ggtggcccca gtgtgggtgt gtgtgtgcgc acagcactgg      960

gggtgctgtg cctctgcctc acaggtgagg ggaagggtca tgatcatgat ggtatgtggg     1020

gatgtccact cctccctggg ctccagccag gctgtctctg tcttgaagaa gcatattgat     1080

ttccatctct gggctccaca ggccaccaac ctcctttacc ttagcctctg cttcttcatc     1140

tgtaaaatgg gacagtatgc tatgataatg caagttcctg aacacactgt gtgaactctg     1200

ctcaggacca ttgccgaaaa ctttctgtcc tcagacacag gcatgactcc attctttatt     1260

ttgttgcaaa cctttgctca gatgacaggt catcagcatg ctttcttgac tactttgtat     1320

aaaacaacat agcactcttc ctccctccct aaatcatccc tgccccgagc gctttattac     1380

attcttccta taatttacct ccactggaca tatggttcct ttgcttattg cctgttgtca     1440

cctcgctcat aaggcaaggt ctaacctcag ggactgaatg gatgattgct atgttcacag     1500

tgctctgtcc ccatgctgaa taaattccca cctagtgctt ggctaagtaa atgccctgtt     1560

taggtagtca tccaccttat ggagaaaaca aagccaagtg tctggcgcca tctagtggtc     1620

atcagagaca acaccatctc tatccgtggg tgttcagact tctttttgtg tgagtgtgtt     1680

tgcttggttg agacagggtc tcactatgtg tacctggctg tccttgaact cattatctag     1740

acaggcaggc ctcaaactca cacagagatc tacctgtctc tgcctcccaa gtgttgggat     1800

aaaaggtgtg tgtcaccaca cttggcctgg ttctaacttc tttagaaaga attttgggtg     1860

actaagctcc atgtcctaga tgtcccctac aaggggacac gtagatctag ttggcaaaga     1920

tgaaaactgg cctgagtttt catggaatca ctgaaagata tcaagggcca gcttcaacct     1980

ctagacatca catactaaga aagagtgtgt gtagaattca tagtaaaaga ctaatcacaa     2040

aacaaataca aattttctaa gccttatatg ggtgctgtat tcagctggct tcatttgaag     2100

cttgtttgtg ctggaaagtt tataggatag aaggcacggg ggccaatagc ggagcctgtt     2160

tctttctctc tctctctctc ccttcctttc tccctccctc cctccctccc tccctccctc     2220

cctccctccc tccctccctc ccccctctct ttctttcttt ctttctttct ttctttcttt     2280

ctttctttct ttctttcttt ctttctttct ttctttcttt tttttttgtt ttttgttttt     2340

ttgagtcagg gtttctctgt ataaccctgg ctgtcctgaa actcactctg tagaccaggc     2400

tggcctcgaa ctcagaaatc cacctgcctc tgtctcccaa gtgctgggat taaaggcgtg     2460

cgccaccact gcccggcacc attttcttat aacttataaa agaaagcatt tcctttgggg     2520

gcttgcttaa caatgtcaga gggtgagtcc atgaccctct ccattatggt ggagaatatg     2580

acagcaggca ggcccgcata gcactggagc agtagctgag agattccatc cgatccacaa     2640

gcacaaagca gagaggagag cacaggcttt tgaaacctca aagcccatgc tagttacaga     2700

tctcctctaa caaggccaca cctcctaatc cttcccaaac agttccaaca gcattcaaac     2760

atatgcacgc gaaggggggg ggggcacatt ctcatttaaa tcaccacaca ttccttcctt     2820

ctcacccttc atcaaccagc aaatattgat aattctctgg gctgcatctt agatctggct     2880

ggtttgctca atccctgtgg ctgctcttca ctgcagggcc tagaacttgc tatgttgacc     2940

aggctggctt caaatttatg gagatcttcc tgcctctgcc tcctgagtgc ttagcctttc     3000

gctgacttgt gctcatagcc tcatgtgtcc tttctacagc tgtgtcgcca tcacttcttt     3060

tgaggacctc tgagctggtc tcccgactac ccaccccctc actcttccac gatagagtct     3120

ccctttatag acgagccggg gtgagcttca ggctttgcta cccagatcac atctaataat     3180

tagtgccctc cgtaatgaca tcctctcgaa ggtgggagac cccaggtttc ttccagcatc     3240

tctcagagcc ccgtctggct ggcctccagt gggcttttcc atgtgctctt tctgatctgc     3300

acctcagggc ctttgtacct gctggtccct cttcctggga cacacttaca tgtgtttcat     3360

agagctcctg cctcacacct tatttaaaga catgggtatt ctttcttgca tagaagttaa     3420

gtatgtttat tcatgaagag aagagaagga aaggcactca tgaagttctc tcacccaagg     3480

gagttcactg agaacagtgg gtgtttagtt ctgcaggcac ccttcctata cagatagtat     3540

ttgtaggaaa atgcaaggga cctggcaggt ggaaagaagc tgccaggctt gaaagctgcc     3600

tcttctttgg ttctttcttt ttctttgact tttataagta cttcctcttt cttctccacc     3660

cacagcttcc cttttttttt tttttttttt tttttttaga atagagcgga tccaaagctg     3720

ggtgatgctc taacaccaag ccctccccct cccccacatt gtctaatcac aagctgatga     3780

acatctgtgt ccatcacaaa ctgcctgcct tccattccga cataaacgag ctccagggta     3840

tgacctgggt cttggtcctt gttgcatttc taattcatgt tggcaaatag ctgcctgcag     3900

tgaggaacat agataggaac ttactctgag cctctgacct gaaaggaagc gtgtgcagag     3960

cctagaggta gctggaaaag gagagagacc ctgaggaaac ctcatctttc ctaactgccc     4020

taccccttcc aactcacccc caggagctgt ggaagtccag gtc                       4063


<210>  7
<211>  5208
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3' homologous arm

<400>  7
cttcagtgct tggggatcta aagagggttc aggctcacct tcatgccaag gtggacagtc       60

actctctgtg tttggccttg acatgtctct gttcagtcct ttagtagatc tgtgtgctgg      120

gtctagcttc ccagtgcctc cctctgggct gtgtgagctt tcccagggtc ctctctgtct      180

ctgagatcag ggtgtctgtc actggtcctt atcttttctc atcccataac ttctgcctgg      240

caccctcagc ccacccagct ttctacttcc aagggttgcc agtgtctgtg tagaccttag      300

gctcattgcg gctcacctct cctgctgagc gtgctggacc ttgtgtgggt ttctctcctg      360

atgaactcag ccagtggcca gcattcatgc ttatctccca ggagtaagtc ttattcctaa      420

ctcttgcttt tttaaggtgt cacctagacc tccccaagac tgaacctacc ttcgctgtag      480

agagccagtc tatgcagcct ctaagggagt cccttcctca gctctctcat attctgaggt      540

accaccttga tcttacagag aacatcgtag gaaagccgtg tttcactggg ttggagagat      600

gccttagtga ctaaaaagcc ttgatgctct atcattgaag accacagagt ttacatccaa      660

gcacacatat atcacgtggc ttgcaaacat ctataattcc aactccaagg gatcagatgc      720

tctttgctgg cctctgtgga taccctcaca cacatgtgtg aacacacgca cgtgtgcgtg      780

cacacacaca cacacacaca cacacacgca tgaacattct tttttaaaaa acaacaacaa      840

caacaacaac aggtctgttt ttttttttgt tgttgttgtt gtttttgttt ttataagaaa      900

gaccaaggag tctggagtga gatgtaagat ggacagatgt gtggaggtta tcaggaagga      960

cagaggactc atgatcaacc tgtaccaagt gggctgggat gtctgtagta tgcttgctgt     1020

gaagcaaggg tttgtatgtg gaaagaacag ttgccctgct tcagagaaca ttacctcagt     1080

agatagcatt gactgaaagg gatttcattt gggctgttgt cgtcaagcac aattcagacg     1140

agatggaggc tcagggaaaa gggactctct cccaagacca cagaccagca cagtggctcc     1200

aaaggatttg ggggccgggc cccactttga aaactgacaa gtgctaaagg cagtggtttg     1260

cctgaagttt ggcgggttcc cagcttctct aaactccatc tgaggagcct ttggatcctt     1320

ttgcggcatt ctgcagcgag cagaggagcc aggatctgaa tctagcattg gcctcttagc     1380

ccagtttctc tcctccccac cggctggcct cctgtttcca ttagagcaga gctggcttac     1440

cttggagccc ttggcctgca tttggctgcg ggcagctctg ccttgtacag cattctggga     1500

tttcagtgct cagtcctctg cctggtctcc ctccacctga agggagttag tgatgttgag     1560

tggcctgtgc caggcatctc tggagagaga gggctttcta gagcaaacac tggaaatgta     1620

ggtctgagcc ccactaactg tgtccttggc caggaggatg aaggcagtct caccctgctt     1680

taggctccgt gtcagggtga accttacctt tgagtatttc agttttttat tagcttctat     1740

taattacata tcaaatagat tatatttcat atatatatga aatataatat ataatatata     1800

catacattct gatcatgctc accccaacac catttcatgt cccctgtcat tccatctgat     1860

ccccttcctc tgcccaacta gtctcctccg attttcatta ctctaaaacc ttagagtgtg     1920

tgtgtgcgcg cgtgcgtgcg tgcgcgtgta tgtgtgtgaa ggtcagagga caactttcag     1980

gaattggtgc tctccttcca ccattggttc tggggctaga actcaggtca ccaggcattc     2040

agagtagact cttttaccag ttggtgtcct tctcccatct taatgtctct atatattttg     2100

tgacactatg gcacagtgag gggtcagtta taggagcttg ggcactttat caagtgacca     2160

tgtttccttc cccctagcga ccattagttg cctgcagttc ttcagggagg gtggagtccc     2220

ttgggtattt ctgctgctct gccctgctca ctgctgcagg agcaccttag acatcttaga     2280

catttccatg tgagggtttc acatgggctc tagactgacc tagtcaccca cctcagctgt     2340

ggcctctgct cctgccctgg cttcttctgc ttcagactcc agagcagcag tgctccaccc     2400

ccctgctccc accccatgtc tgtgcaaagc atagctactg ccaagactta ccacaattcc     2460

tggatgcagg ctgccgggtc ccgctgcctg ggttctccac tgtggctgct gatgccctgg     2520

ctgcctgctg tttccagaga gcataaggaa tcaagctgtc tttgttagtg ccccaacctg     2580

caccggcagc ggctctgccc tggacccagt gtggcactgg gctcaggatg atagctatgc     2640

tggagtcatg tggggtatgt gctcagaaca gctgctggtc ccaatcccac cttagttgct     2700

ctgcctccac acactccttg acatgagata tctaatgggg agcctcacgt tgcacgtgaa     2760

tattggcgag gctctcccag atctgtatgg atccttaagt gacttagact ctcactccag     2820

gccctcatct atgtgcagtg agtgacagag agtactttgt gggcggtgtt ccatctctct     2880

gctgatgatt gattggcagg atctccttgt cgcagtttta ctgttgattg attgattgac     2940

tggcaggatc tcagttgacc ttgaactaaa tatgtcacga ggatgacctt gagtttcttc     3000

tcctcccacc tctacctcct tagttcttgg attccagggg gctcgggaaa caatgcccag     3060

ttcatgtgct gctgggaata gaacccggag cttcttgtgt tttaggcaag caaatggtct     3120

accaactgag atacatctcc agagaaccat agctttcctt tccgttcttt tttttctttc     3180

tcctttcttt ttgtagcccc tttccaaata taaaagctaa tactagctcc tggattgtcc     3240

aaagcaggcc acagtctgac tcatgggctg tcgctggctg atgcctgatc ttcaggatga     3300

tgtaaaccag gtaggactgt aacctcgagg gaggtgtctg gagaggtgat tgctaggaag     3360

ggaaaatgac agcgactgtg tagatcctgg aaggagtcag gactaattct gtagagaatg     3420

gccgaagtgg ggtttcctgt ggcgacatta gacagaaaag ctgggagctg ggtcagctta     3480

gagaccctta gagatccagc cattcgtgcc tgcgtgtctt ggggcacatc actgttttag     3540

tttagtttat ttggtgcagc tgtaagagga ttcctgagac aggtcatgta aagaacagac     3600

atttggtgat agctcagtgg ttaagagcac tggctgccct tccagaggtc ctgagttcaa     3660

ttcccagcaa ctacatgatg gcttacaacc atatcagaat gaaatctgat gccccctgtc     3720

tggtatgccg gtgtacatac agatatacat taaataaata aaacttaaaa aaaaaaaaga     3780

aagaacattt actggcatgt gcatctcaag ctgagagtac catacccaga cagctgggag     3840

agcagagaaa gaaagctctt gccacagaag gatgaaggct ggtgtttgga atccccctct     3900

tagaagacag aacggttatc ctaggtcagt gaggccctat ccatggttat tagtcagcct     3960

caggcttctt agcttcccct cttcccttct gaggtgaacc catagccaca atggcagggt     4020

ttggtggggt gagtagagct gtgactctgg gagccctggc catgggagcc tcagtgagca     4080

tcattgacct tggtggcgta ggagcttggg agcccctgtt cacaccgtag aacaagatgg     4140

tctcatgctt ctttcttcct cttctagggc agcccctgac attcccccct gaggctctgt     4200

gggtaaccgt ggggctctct gtctgtcttg tggtactact ggtggccctg gctttcgtgt     4260

gctggagaaa gatcaagcag agctgcgagg aggagaatgc aggtgaggga gagtgactcg     4320

cgtgtgcgtg cgtgcgtgtg tttgtgtgta tgtgtgtgtg tgtgtgcgag tgttgtacat     4380

acatgcctgc atgtcttggg gcatgtcact gttttcgttt tttggttcag ctgtaagaga     4440

atacccgaga cagggtcatg taaaggacag acatgtactg gcttgtgttt ctcaagctgt     4500

gggtatccta tccagacagc tgggagagca cagaaaacac ttgccacaga aggacgaaag     4560

ttggagtttg caaccctagc acctacataa atgtctagtg ggcatggcag cttgtctgta     4620

attccagctc ttagaaggag gagacatgag cttccccagc cagactagcc acatcagtga     4680

gctctgggtt caactgagag acctggtctt aatgaataag catggagtga ccaagaagac     4740

tcctgacatc acccacacac atgtaaacag gcatgcacac atgcacgagt accacacact     4800

cggctgcatg cacaaagtaa gtaagtcaat accatgtcca ggatctgccc ccctggagag     4860

gccttgctgc tcattaaatg gtggaaagcg agagggcaaa ggccatagcg cccatcctat     4920

ctgcaagggt ggggtggtca gagcctaatt aatcaccctt tagaagcatc gcctctttag     4980

gaaacaaaat taatgtaaaa gttaaattta tttttttaat ttaaagtttt tgtatatggg     5040

tgttttgcct gcatgcaggt ctggaactga agtcacagtg gttattagct gccacatggc     5100

tgctgagaac agaatcttgt tctctataag agcagacagt gctctttaac cactgagcca     5160

tcttctcctg cccagaagtc acaccccttg atactgtttg atggcagc                  5208


<210>  8
<211>  61
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the connection between the 5' end of the human CD276 gene 
       sequence in the A fragment and the mouse CD276 gene locus

<400>  8
tcacccccag gagctgtgga agtccaggtc cctgaagacc cagtggtggc actggtgggc       60

a                                                                       61


<210>  9
<211>  71
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the connection between the 3' end of the human CD276 gene 
       sequence and the mouse CD276 gene locus

<400>  9
actggcaacg tgaccacgtc gcagatggcc aacgagcagg gcttgttcga tgttcacagc       60

gtgctgaggg t                                                            71


<210>  10
<211>  104
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the connection between the 5' end of the Neo cassette and the 
       mouse CD276 gene locus

<400>  10
cttaaatctc tggtttccag gtcagcacta gttcaagtag gcaccaattg aagcttgata       60

tcgaattccg aagttcctat tctctagaaa gtataggaac ttca                       104


<210>  11
<211>  100
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  the connection between the 3' end of the Neo cassette with the 
       mouse CD276 sequence

<400>  11
aagttcctat tctctagaaa gtataggaac ttcatcagtc aggtacataa tggtggatcc       60

cttcagtgct tggggatcta aagagggttc aggctcacct                            100


<210>  12
<211>  3851
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  mRNA sequence of the engineered mouse CD276 after humanization

<400>  12
cggcgcggcg cgccaaagtg acctggtaca gcctggaccc caagctcatc ggctttgtct       60

ggctggccgc ctggcctctt cccacttgga tttggatgat cctgaggcct ttggaggaac      120

ttcgagacaa aggcccctct tcctcttcca cgggcaggag cagccattcg ccacggagag      180

cccagctgtc agctgtctca caggaagatg cttcgaggat ggggtggccc cagtgtgggt      240

gtgtgtgtgc gcacagcact gggggtgctg tgcctctgcc tcacaggagc tgtggaagtc      300

caggtccctg aagacccagt ggtggcactg gtgggcaccg atgccaccct gtgctgctcc      360

ttctcccctg agcctggctt cagcctggca cagctcaacc tcatctggca gctgacagat      420

accaaacagc tggtgcacag ctttgctgag ggccaggacc agggcagcgc ctatgccaac      480

cgcacggccc tcttcccgga cctgctggca cagggcaacg catccctgag gctgcagcgc      540

gtgcgtgtgg cggacgaggg cagcttcacc tgcttcgtga gcatccggga tttcggcagc      600

gctgccgtca gcctgcaggt ggccgctccc tactcgaagc ccagcatgac cctggagccc      660

aacaaggacc tgcggccagg ggacacggtg accatcacgt gctccagcta ccagggctac      720

cctgaggctg aggtgttctg gcaggatggg cagggtgtgc ccctgactgg caacgtgacc      780

acgtcgcaga tggccaacga gcagggcttg tttgatgtgc acagcatcct gcgggtggtg      840

ctgggtgcaa atggcaccta cagctgcctg gtgcgcaacc ccgtgctgca gcaggatgcg      900

cacagctctg tcaccatcac accccagaga agccccacag gagccgtgga ggtccaggtc      960

cctgaggacc cggtggtggc cctagtgggc accgatgcca ccctgcgctg ctccttctcc     1020

cccgagcctg gcttcagcct ggcacagctc aacctcatct ggcagctgac agacaccaaa     1080

cagctggtgc acagtttcac cgaaggccgg gaccagggca gcgcctatgc caaccgcacg     1140

gccctcttcc cggacctgct ggcacaaggc aatgcatccc tgaggctgca gcgcgtgcgt     1200

gtggcggacg agggcagctt cacctgcttc gtgagcatcc gggatttcgg cagcgctgcc     1260

gtcagcctgc aggtggccgc tccctactcg aagcccagca tgaccctgga gcccaacaag     1320

gacctgcggc caggggacac ggtgaccatc acgtgctcca gctaccgggg ctaccctgag     1380

gctgaggtgt tctggcagga tgggcagggt gtgcccctga ctggcaacgt gaccacgtcg     1440

cagatggcca acgagcaggg cttgttcgat gttcacagcg tgctgagggt ggtgctgggt     1500

gctaacggca cctacagctg cctggtacgc aacccggtgt tgcagcaaga tgctcacggc     1560

tcagtcacca tcacagggca gcccctgaca ttcccccctg aggctctgtg ggtaaccgtg     1620

gggctctctg tctgtcttgt ggtactactg gtggccctgg ctttcgtgtg ctggagaaag     1680

atcaagcaga gctgcgagga ggagaatgca ggtgccgagg accaggatgg agatggagaa     1740

ggatccaaga cagctctacg gcctctgaaa ccctctgaaa acaaagaaga tgacggacaa     1800

gaaattgctt gattgggagc tgctgccctt cccaggtggg gggcccaccc tctggcagtg     1860

ttgagcttca atgcgagccc ttcccccaac gaatgggttt gtcccacaga tctacccgtt     1920

cgtcaaagga cgtggtccat agaccaccca cagccttact tttccaatgg acttaattcc     1980

catcatcctg cagcctcatt tctccagtga cacgatacac gaaccatcct gcggccttat     2040

ttcccacgga cacgacacaa agatgtccct cctcggtgtt cctccagagt cgtctggtgg     2100

ccttgtgata cggcgtgaac cttcttcctt ctgccttacg tctaatggac acacacgcac     2160

cacccccaca cccttgctcc tccaaagcca tgcagactgt gtaactgcta ttattctcca     2220

aggggcatcc tgtgcagatg aaaccctgct ttatttccct gaagacagct gcacagtgac     2280

ctcttagttc ttgctcccat ggccctgatg tatcctagtt accagccctc aacctcagtt     2340

ctgagggtgg gatcccatcg ctcagcaagg cttcatcctg acctccctgc cctgatctga     2400

tctggccctg gcttttgttg tctcgctccc tgactaagtg agatggggca ctctcccgcc     2460

cccgcccccc ccaggtcaca gatacctacc tgcagctgtg cgtgctggat cacgcacata     2520

cttgccttgc atggtctcct ggctgccctg ggctgtgcct gttcttccat aggaagcaag     2580

ttcttgtctc cctggttctc agggcccctc aggggctcag ccttcagccc tgtgcttccc     2640

catgttggga atctttgtta cctttttctt ctttgtaaat taacatctga taacaaccac     2700

agggtccaat gggactttca cagacctgcc agctagataa ataatgacaa cagaagttta     2760

ttaatatttt aagacttagg ccttttgctg ggcagcctcc caactattct atcctgacta     2820

atcctggcac tatgtcccac cacatggcca ggtctacctc tctgctccac tctccatcca     2880

cctccatgtc tgccagcaaa tctcccgtga ttcagttctt ctcccagagt ccctatctct     2940

gcccagaagt accatcttcg acttcctgcc caactattgg ccgtcagctc ttcattaaag     3000

ccgatcagat gtaattctag attgccttag gcaggtgagg aagaaacaag tatttgtaaa     3060

atatgagacc agcaatgggc catagaaata acagcaccag atcctgccag catttagccc     3120

tctgttggta caaaattaac aattgaatat acagagacct acttccagag tgtaccccaa     3180

caacaggcgt gagcatggtg ctgggtacta gggtcctgct ggaaaatcag agaccttacc     3240

tacagctggg acatgacctt gcttccgact tacccaccac ttctggatac ctcaccctca     3300

gcccacacta tccctggcct agggcccagg gtagagccag aaacatggag aaagcatggc     3360

cccttgccgt acctggagaa ctgggtattt tccagagtct ttatagatgt ggactggaag     3420

gcaggtggcc acagccgtgc agacctgggt caggtcagaa acctatgcca tgctgggacc     3480

tactcaacag cagaagcatg aagagggcct gaggacaaga aaggccttct taccatggtg     3540

ctattctgga gctgggatat atacctggct tgtctctgac tgccctggct tctggcagaa     3600

cttctgatgt cctcctgaag gcctctctcc caccccagta cctgagaacc tgaggataat     3660

ttaaacatgg gactctggcc agcacctggg agagacaggt agatctctga tttttgactc     3720

agcctggtct atcgagtgag ttccaggaca tctggggcta cacagagaaa ccatcttaaa     3780

gactaaaaat aataaacatg agactgtaaa ctgggtgtat tttgggagaa ataaatgtct     3840

ttttctttca a                                                          3851


<210>  13
<211>  534
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  encoded protein sequence of the engineered mouse CD276 after 
       humanization

<400>  13

Met Leu Arg Gly Trp Gly Gly Pro Ser Val Gly Val Cys Val Arg Thr 
1               5                   10                  15      


Ala Leu Gly Val Leu Cys Leu Cys Leu Thr Gly Ala Val Glu Val Gln 
            20                  25                  30          


Val Pro Glu Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu 
        35                  40                  45              


Cys Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Ala 
65                  70                  75                  80  


Glu Gly Gln Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Ala Asp Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp 
        115                 120                 125             


Phe Gly Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Gln Asp Gly Gln Gly Val Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Gln Gly Leu Phe Asp Val His Ser Ile Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Ser Ser Val Thr Ile Thr Pro Gln 
225                 230                 235                 240 


Arg Ser Pro Thr Gly Ala Val Glu Val Gln Val Pro Glu Asp Pro Val 
                245                 250                 255     


Val Ala Leu Val Gly Thr Asp Ala Thr Leu Arg Cys Ser Phe Ser Pro 
            260                 265                 270         


Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp Gln Leu Thr 
        275                 280                 285             


Asp Thr Lys Gln Leu Val His Ser Phe Thr Glu Gly Arg Asp Gln Gly 
    290                 295                 300                 


Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu Ala Gln 
305                 310                 315                 320 


Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp Glu Gly 
                325                 330                 335     


Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala Ala Val 
            340                 345                 350         


Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser Met Thr Leu Glu 
        355                 360                 365             


Pro Asn Lys Asp Leu Arg Pro Gly Asp Thr Val Thr Ile Thr Cys Ser 
    370                 375                 380                 


Ser Tyr Arg Gly Tyr Pro Glu Ala Glu Val Phe Trp Gln Asp Gly Gln 
385                 390                 395                 400 


Gly Val Pro Leu Thr Gly Asn Val Thr Thr Ser Gln Met Ala Asn Glu 
                405                 410                 415     


Gln Gly Leu Phe Asp Val His Ser Val Leu Arg Val Val Leu Gly Ala 
            420                 425                 430         


Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn Pro Val Leu Gln Gln Asp 
        435                 440                 445             


Ala His Gly Ser Val Thr Ile Thr Gly Gln Pro Leu Thr Phe Pro Pro 
    450                 455                 460                 


Glu Ala Leu Trp Val Thr Val Gly Leu Ser Val Cys Leu Val Val Leu 
465                 470                 475                 480 


Leu Val Ala Leu Ala Phe Val Cys Trp Arg Lys Ile Lys Gln Ser Cys 
                485                 490                 495     


Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln Asp Gly Asp Gly Glu Gly 
            500                 505                 510         


Ser Lys Thr Ala Leu Arg Pro Leu Lys Pro Ser Glu Asn Lys Glu Asp 
        515                 520                 525             


Asp Gly Gln Glu Ile Ala 
    530                 


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  14
gctcgactag agcttgcgga                                                   20


<210>  15
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  15
tctgttcatc ctctcacagg cacag                                             25


<210>  16
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  16
ctgtgtacct gaggctagac cacatg                                            26


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  17
agggatgcgt tgccctgtgc                                                   20


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  18
ggcagcagat ggggctaaga tgaat                                             25


<210>  19
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  19
cgaaagacta cagagtgctt tggcct                                            26


<210>  20
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  20
tgcgtttggg agggaaacag acatt                                             25


<210>  21
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  21
aactgtgagg ctctgaacat tcggc                                             25


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  22
ggatcggcca ttgaacaaga t                                                 21


<210>  23
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  23
cagaagaact cgtcaagaag gc                                                22


<210>  24
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
actctgagcc tctgacctga aagga                                             25


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
gaagcagagg gtacccctct cc                                                22


<210>  26
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  26
tgtagaccat gtagttgagg tca                                               23


<210>  27
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
agggatgcgt tgccctgtgc                                                   20


<210>  28
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
agactcacac tggaggagtc tctt                                              24


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  29
tcagagacag agaggaccct ggg                                               23


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
ggaccaaggc agtgcctact                                                   20


<210>  31
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
tggtcaccat gttccctgga cgt                                               23


<210>  32
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  32
cagctggtgc acagctttgc t                                                 21


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
ggcagctgta ggtgccattt gca                                               23


<210>  34
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
aggtcggtgt gaacggattt g                                                 21


<210>  35
<211>  316
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Met Leu Arg Gly Trp Gly Gly Pro Ser Val Gly Val Ser Met Gly Thr 
1               5                   10                  15      


Ala Leu Gly Val Leu Cys Leu Cys Leu Thr Gly Ala Val Glu Val Gln 
            20                  25                  30          


Val Ser Glu Asp Pro Val Val Ala Leu Val Asp Thr Asp Ala Thr Leu 
        35                  40                  45              


Arg Cys Ser Phe Ser Pro Glu Pro Gly Phe Ser Leu Arg Gln Leu Asn 
    50                  55                  60                  


Leu Ile Trp Gln Leu Thr Asp Thr Lys Gln Leu Val His Ser Phe Thr 
65                  70                  75                  80  


Glu Gly Arg Asp Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe 
                85                  90                  95      


Pro Asp Leu Leu Val Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val 
            100                 105                 110         


Arg Val Thr Asp Glu Gly Ser Tyr Thr Cys Phe Val Ser Ile Gln Asp 
        115                 120                 125             


Phe Asp Ser Ala Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys 
    130                 135                 140                 


Pro Ser Met Thr Leu Glu Pro Asn Lys Asp Leu Arg Pro Gly Asp Met 
145                 150                 155                 160 


Val Thr Ile Thr Cys Ser Ser Tyr Gln Gly Tyr Pro Glu Ala Glu Val 
                165                 170                 175     


Phe Trp Lys Asp Gly Gln Gly Leu Pro Leu Thr Gly Asn Val Thr Thr 
            180                 185                 190         


Ser Gln Met Ala Asn Glu Arg Gly Leu Phe Asp Val His Ser Val Leu 
        195                 200                 205             


Arg Val Val Leu Gly Ala Asn Gly Thr Tyr Ser Cys Leu Val Arg Asn 
    210                 215                 220                 


Pro Val Leu Gln Gln Asp Ala His Gly Ser Val Thr Ile Thr Gly Gln 
225                 230                 235                 240 


Pro Met Thr Phe Pro Pro Glu Ala Leu Trp Val Thr Val Gly Leu Ser 
                245                 250                 255     


Val Cys Leu Val Ile Leu Leu Val Ala Leu Ala Phe Val Cys Trp Arg 
            260                 265                 270         


Lys Ile Lys Gln Ser Cys Glu Glu Glu Asn Ala Gly Ala Glu Asp Gln 
        275                 280                 285             


Asp Gly Asp Gly Glu Gly Ser Lys Thr Ala Leu Arg Pro Leu Lys His 
    290                 295                 300                 


Ser Glu Asn Lys Glu Asp Asp Gly Gln Glu Ile Ala 
305                 310                 315     


