                        б

<110>  ɽ̴Ƽ޹˾
 
<120>  ǻ׺ＰӦ

<130>  P2021TC1613

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  182
<212>  PRT
<213>  Homo sapiens

<220>
<223>  ҰHǻ

<400>  1

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Cys Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  2
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-1

<400>  2

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Cys Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  3
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-2

<400>  3

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Cys 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  4
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-3

<400>  4

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Cys Leu Gln Asp Ile Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  5
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-4

<400>  5

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Cys Gln Asp Ile Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  6
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-5

<400>  6

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Cys Asp Ile Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  7
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-6

<400>  7

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Cys Ile Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  8
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-7

<400>  8

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Cys Lys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  9
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-8

<400>  9

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Cys Lys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  10
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-9

<400>  10

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Cys Pro Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  11
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-10

<400>  11

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Cys Asp Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  12
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-11

<400>  12

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Cys Ser Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  13
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-12

<400>  13

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  14
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-13

<400>  14

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Ser Cys Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ser Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ser Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  15
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-1

<400>  15
accaccgcaa gtacctcaca ggtgcgccag aattatcatc aggatagcga agcagccatt       60

aatcgtcaga ttaatctgga actgtatgcc tcttatgtgt atctgtctat gagctattat      120

tttgatcgcg atgatgtggc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaactgcaga atcagcgtgg tggttgtatt      240

tttctgcagg atattaaaaa accggattca gatgattggg aaagcggcct gaatgcgatg      300

gaaagcgcct tacatttaga aaaaaatgtt aatcagtcac tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgagt gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga attaggcgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  16
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-2

<400>  16
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagcaatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgagtat gagctattat      120

tttgatcgcg atgatgtggc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgtgg tggtcgttgt      240

tttctgcagg atattaaaaa accggatagc gatgattggg aaagtggcct gaatgctatg      300

gaaagtgcct tacatttaga aaaaaatgtt aatcagtctc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggtgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  17
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-3

<400>  17
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagcaatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgtctat gtcttattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaactgcaga atcagcgtgg tggtcgtatt      240

tgtttacagg atattaaaaa accggattca gatgattggg aaagtggcct gaatgcaatg      300

gaaagtgcct tacatctgga aaaaaatgtt aatcagagcc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgagt gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggcgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  18
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-4

<400>  18
accaccgcaa gtacctcaca ggtgcgccag aattatcatc aggatagtga agcagcaatt       60

aatcgtcaga ttaatctgga actgtatgca agctatgtgt atctgtctat gtcttattat      120

tttgatcgtg atgatgtggc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaactgcaga atcagcgtgg tggtcgcatt      240

ttttgtcagg atattaaaaa accggatagc gatgattggg aaagcggcct gaatgcgatg      300

gaaagtgcct tacatttaga aaaaaatgtt aatcagagcc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgagc gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga attaggcgat catgttacca atttacgtaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  19
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-5

<400>  19
accaccgcct ctacctcaca ggtgcgccag aattatcatc aggatagcga agcagccatt       60

aatcgtcaga ttaatctgga actgtatgcc tcttatgtgt atctgagtat gagctattat      120

tttgatcgtg atgatgtggc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgtgg tggtcgtatt      240

tttctgtgtg atattaaaaa accggattca gatgattggg aaagcggcct gaatgcgatg      300

gaaagtgcac tgcatctgga aaaaaatgtt aatcagtcac tgttagaact gcataaactg      360

gcaaccgata aaaatgatcc gcatttaagc gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgttacca atttacgcaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  20
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-6

<400>  20
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagcaatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgtctat gtcatattat      120

tttgatcgtg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaactgcaga atcagcgcgg tggtcgcatt      240

tttctgcagt gtattaaaaa accggatagt gatgattggg aaagcggcct gaatgcgatg      300

gaaagtgcct tacatctgga aaaaaatgtt aatcagagcc tgctggaatt acataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggcgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagcgataat      540

gaatct                                                                 546


<210>  21
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-7

<400>  21
accaccgcct ctacctcaca ggtgcgtcag aattatcatc aggatagcga agcagccatt       60

aatcgccaga ttaatctgga actgtatgca agctatgtgt atctgtctat gtcttattat      120

tttgatcgtg atgatgttgc actgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgcgg tggtcgtatt      240

tttctgcagg attgtaaaaa accggatagt gatgattggg aaagtggcct gaatgcaatg      300

gaaagtgccc tgcatttaga aaaaaatgtt aatcagagtt tactggaatt acataaactg      360

gcaaccgata aaaatgatcc gcatctgagc gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgtgacca atttacgcaa aatgggcgcc      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga ttcagataat      540

gaatct                                                                 546


<210>  22
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-8

<400>  22
accaccgcct ctacctcaca ggtgcgtcag aattatcatc aggatagcga agcagccatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgagtat gagctattat      120

tttgatcgtg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgcgg tggtcgcatt      240

tttctgcagg atatttgtaa accggatagc gatgattggg aaagtggcct gaatgcaatg      300

gaaagtgcct tacatctgga aaaaaatgtt aatcagtcac tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  23
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-9

<400>  23
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagcaatt       60

aatcgccaga ttaatttaga actgtatgcc tcttatgtgt atctgtctat gagctattat      120

tttgatcgtg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaactgcaga atcagcgcgg tggtcgcatt      240

tttctgcagg atattaaatg tccggatagt gatgattggg aaagcggcct gaatgcgatg      300

gaaagtgcac tgcatctgga aaaaaatgtt aatcagagcc tgctggaatt acataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggcgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagcgataat      540

gaatct                                                                 546


<210>  24
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-10

<400>  24
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagccatt       60

aatcgccaga ttaatctgga actgtatgcc tcttatgtgt atctgtctat gagctattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgtgg tggtcgtatt      240

tttctgcagg atattaaaaa atgtgattca gatgattggg aaagtggcct gaatgcgatg      300

gaaagcgcct tacatttaga aaaaaatgtt aatcagtcac tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgagt gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgtgacca atttacgtaa aatgggtgca      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  25
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-11

<400>  25
accaccgcaa gtacctcaca ggtgcgtcag aattatcatc aggatagcga agcagccatt       60

aatcgccaga ttaatctgga actgtatgcc tcttatgtgt atctgtctat gagctattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagagtcat      180

gaagaacgtg aacatgccga aaaactgatg aaattacaga atcagcgcgg tggtcgtatt      240

tttctgcagg atattaaaaa accgtgtagc gatgattggg aaagcggcct gaatgcgatg      300

gaaagtgcac tgcatttaga aaaaaatgtt aatcagtctc tgctggaatt acataaactg      360

gcaaccgata aaaatgatcc gcatctgagc gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggtgat catgtgacca atttacgcaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  26
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-12

<400>  26
accaccgcct ctacctcaca ggttcgtcag aattatcatc aggatagtga agcagcaatt       60

aatcgccaga ttaatttaga actgtatgca agctatgtgt atctgagtat gagctattat      120

tttgatcgcg atgatgtggc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaactgcaga atcagcgtgg tggtcgcatt      240

tttctgcagg atattaaaaa accggattgt gatgattggg aaagtggcct gaatgctatg      300

gaaagtgcct tacatctgga aaaaaatgtt aatcagtcac tgctggaatt acataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag ccattaaaga actgggtgat catgttacca atttacgtaa aatgggcgca      480

ccggaaagcg gcttagccga atatctgttt gataaacata ccttaggcga tagcgataat      540

gaatct                                                                 546


<210>  27
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HFn-Mut-13

<400>  27
accaccgcct ctacctcaca ggtgcgccag aattatcatc aggatagcga agcagccatt       60

aatcgtcaga ttaatttaga actgtatgca agctatgtgt atctgagtat gagctattat      120

tttgatcgcg atgatgttgc cctgaaaaat tttgccaaat attttctgca tcagtctcat      180

gaagaacgcg aacatgccga aaaactgatg aaattacaga atcagcgtgg tggtcgcatt      240

tttctgcagg atattaaaaa accggattct tgtgattggg aaagcggcct gaatgcaatg      300

gaaagtgcct tacatctgga aaaaaatgtt aatcagtcac tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctgtca gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgtgacca atttacgtaa aatgggcgcc      480

ccggaaagtg gcttagccga atatctgttt gataaacata ccttaggcga tagtgataat      540

gaatct                                                                 546


<210>  28
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mut-12

<400>  28

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Cys Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Ala Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  29
<211>  182
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mut-12"

<400>  29

Thr Thr Ala Ser Thr Ser Gln Val Arg Gln Asn Tyr His Gln Asp Ser 
1               5                   10                  15      


Glu Ala Ala Ile Asn Arg Gln Ile Asn Leu Glu Leu Tyr Ala Ser Tyr 
            20                  25                  30          


Val Tyr Leu Ser Met Ser Tyr Tyr Phe Asp Arg Asp Asp Val Ala Leu 
        35                  40                  45              


Lys Asn Phe Ala Lys Tyr Phe Leu His Gln Ser His Glu Glu Arg Glu 
    50                  55                  60                  


His Ala Glu Lys Leu Met Lys Leu Gln Asn Gln Arg Gly Gly Arg Ile 
65                  70                  75                  80  


Phe Leu Gln Asp Ile Lys Lys Pro Asp Glu Asp Asp Trp Glu Ser Gly 
                85                  90                  95      


Leu Asn Ala Met Glu Cys Ala Leu His Leu Glu Lys Asn Val Asn Gln 
            100                 105                 110         


Ser Leu Leu Glu Leu His Lys Leu Ala Thr Asp Lys Asn Asp Pro His 
        115                 120                 125             


Leu Ala Asp Phe Ile Glu Thr His Tyr Leu Asn Glu Gln Val Lys Ala 
    130                 135                 140                 


Ile Lys Glu Leu Gly Asp His Val Thr Asn Leu Arg Lys Met Gly Ala 
145                 150                 155                 160 


Pro Glu Ser Gly Leu Ala Glu Tyr Leu Phe Asp Lys His Thr Leu Gly 
                165                 170                 175     


Asp Ser Asp Asn Glu Ser 
            180         


<210>  30
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mut-12

<400>  30
accaccgcaa gtacctctca ggtgcgccag aattatcatc aggatagcga agcagcaatt       60

aatcgtcaga ttaatctgga actgtatgca agctatgtgt atctgtctat gtcttattat      120

tttgatcgcg atgatgtggc actgaaaaat tttgcaaaat attttctgca tcagtcacat      180

gaagaacgcg aacatgcaga aaaactgatg aaacttcaaa atcagcgtgg tggtcgtatt      240

tttttgcaag atattaaaaa accggattgt gatgattggg aaagtggcct gaatgcaatg      300

gaagcagcac tgcatctgga aaaaaatgtt aatcagagcc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctggca gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgttacca atctgcgtaa aatgggcgca      480

ccggaaagcg gcctggcaga atatctgttt gataaacata ccctgggcga tagtgataat      540

gaaagc                                                                 546


<210>  31
<211>  546
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mut-12"

<400>  31
accaccgcaa gtacctctca ggtgcgccag aattatcatc aggatagcga agcagcaatt       60

aatcgtcaga ttaatctgga actgtatgca agctatgtgt atctgtctat gtcttattat      120

tttgatcgcg atgatgtggc actgaaaaat tttgcaaaat attttctgca tcagtcacat      180

gaagaacgcg aacatgcaga aaaactgatg aaactacaga atcagcgtgg tggtcgtatt      240

tttctccagg atattaaaaa accggatgaa gatgattggg aaagtggcct gaatgcaatg      300

gaatgtgcac tgcatctgga aaaaaatgtt aatcagagcc tgctggaact gcataaactg      360

gcaaccgata aaaatgatcc gcatctggca gattttattg aaacccatta tctgaatgaa      420

caggttaaag caattaaaga actgggcgat catgttacca atctgcgtaa aatgggcgca      480

ccggaaagcg gcctggcaga atatctgttt gataaacata ccctgggcga tagtgataat      540

gaaagc                                                                 546


<210>  32
<211>  174
<212>  PRT
<213>  Homo sapiens

<220>
<223>  Ұ(L)ǻ

<400>  32

Ser Ser Gln Ile Arg Gln Asn Tyr Ser Thr Asp Val Glu Ala Ala Val 
1               5                   10                  15      


Asn Ser Leu Val Asn Leu Tyr Leu Gln Ala Ser Tyr Thr Tyr Leu Ser 
            20                  25                  30          


Leu Gly Phe Tyr Phe Asp Arg Asp Asp Val Ala Leu Glu Gly Val Ser 
        35                  40                  45              


His Phe Phe Arg Glu Leu Ala Glu Glu Lys Arg Glu Gly Tyr Glu Arg 
    50                  55                  60                  


Leu Leu Lys Met Gln Asn Gln Arg Gly Gly Arg Ala Leu Phe Gln Asp 
65                  70                  75                  80  


Ile Lys Lys Pro Ala Glu Asp Glu Trp Gly Lys Thr Pro Asp Ala Met 
                85                  90                  95      


Lys Ala Ala Met Ala Leu Glu Lys Lys Leu Asn Gln Ala Leu Leu Asp 
            100                 105                 110         


Leu His Ala Leu Gly Ser Ala Arg Thr Asp Pro His Leu Cys Asp Phe 
        115                 120                 125             


Leu Glu Thr His Phe Leu Asp Glu Glu Val Lys Leu Ile Lys Lys Met 
    130                 135                 140                 


Gly Asp His Leu Thr Asn Leu His Arg Leu Gly Gly Pro Glu Ala Gly 
145                 150                 155                 160 


Leu Gly Glu Tyr Leu Phe Glu Arg Leu Thr Leu Lys His Asp 
                165                 170                 


