                         SEQUENCE LISTING

<110>  ZYMEWORKS INC.
 
<120>  HETERODIMERIC Fc VARIANTS SELECTIVE FOR Fc GAMMA RIIB

<130>  V816743WO

<140>  PCT/CA2021/050690
<141>  2021-05-20

<150>  63/027,787
<151>  2020-05-20

<160>  186   

<170>  PatentIn version 3.5

<210>  1
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc sequence 231-447 (EU-numbering)

<400>  1

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  2
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain A, upper hinge, CH2 and CH3 domains

<400>  2

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Val Tyr Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Ala Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  3
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain B, upper hinge, CH2 and CH3 domains

<400>  3

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Leu Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Leu Thr Trp Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 231 1QVC (Bacteria)

<400>  4

Trp Thr Asp Gln Ser Gly Gln Asp Arg 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 168 1LN1 (Human)

<400>  5

Leu Asp Met Glu Gly Arg Lys Ile His 
1               5                   


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 2GKO (Parental)

<400>  6

Ser Thr Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 11 2DWC

<400>  7

His Phe Asp Glu Asn Gly Glu Ile Val Thr 
1               5                   10  


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 4R3O (Human - Parental)

<400>  8

Gly Leu Asp Glu Glu Gly Lys Gly Ala Val 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 19 1OID (Bacteria - Parental)

<400>  9

Val Thr Trp Glu Asp Gly Lys Ser Glu Arg 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 38 3GVE (Bacteria)

<400>  10

Leu Ile Asp Glu Asn Gly Asn Glu Gln Lys 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 60 3E35 (Bacteria)

<400>  11

Val Gln Asp Ala Thr Gly Ala Pro Phe Leu 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 1IJR (Human - Parental)

<400>  12

Asp Phe Asp Gln Asn Gln Gly Glu Val Val 
1               5                   10  


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 83 2X6C (Bacteria)

<400>  13

Ser Asp Phe Glu Gly Lys Pro Thr Leu 
1               5                   


<210>  14
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 4JN3 (Bacteria - Parental)

<400>  14

Leu Thr Asp Glu Glu Gly Arg Pro Tyr Arg 
1               5                   10  


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ F328*E_ D329*G_ A331*BN)

<400>  15

Ala His Trp Glu Gly Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ F328*Q_ D329*G_ A331*BN)

<400>  16

Ala His Trp Gln Gly Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*Q)

<400>  17

Ser Gln Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*N)

<400>  18

Ser Asn Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (Y331*AF)

<400>  19

Ser Thr Trp Phe Asp Gly Gly Phe Ala Thr 
1               5                   10  


<210>  20
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*E)

<400>  20

Ser Thr Trp Phe Asp Glu Gly Tyr Ala Thr 
1               5                   10  


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*D)

<400>  21

Ser Thr Trp Phe Asp Asp Gly Tyr Ala Thr 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*A)

<400>  22

Ser Thr Trp Phe Asp Ala Gly Tyr Ala Thr 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*L)

<400>  23

Ser Leu Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*I)

<400>  24

Ser Ile Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*E)

<400>  25

Ser Glu Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*D)

<400>  26

Ser Asp Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*A)

<400>  27

Ser Ala Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*F)

<400>  28

Ser Phe Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*T)

<400>  29

Ser His Trp Thr Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*S_ A331*BN)

<400>  30

Ser His Trp Ser Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*S)

<400>  31

Ser His Trp Ser Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*Q_ D329*G_ A331*BN)

<400>  32

Ser His Trp Gln Gly Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  33
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*Q_ D329*G)

<400>  33

Ser His Trp Gln Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  34
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*Q)

<400>  34

Ser His Trp Gln Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  35
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*N)

<400>  35

Ser His Trp Asn Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*H_ D329*G)

<400>  36

Ser His Trp His Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*H)

<400>  37

Ser His Trp His Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  38
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H)

<400>  38

Ser His Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*E_ D329*G_ A331*BN)

<400>  39

Ser His Trp Glu Gly Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*E_ D329*G)

<400>  40

Ser His Trp Glu Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*D)

<400>  41

Ser His Trp Asp Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ A331*BN)

<400>  42

Ser His Trp Phe Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*H_ D329*G)

<400>  43

Ser Thr Trp His Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*H)

<400>  44

Ser Thr Trp His Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  45
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*Q_ D329*G)

<400>  45

Ser Thr Trp Gln Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (D329*L)

<400>  46

Ser Thr Trp Phe Leu Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (D329*I)

<400>  47

Ser Thr Trp Phe Ile Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*S)

<400>  48

Ser Thr Trp Ser Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*S_ A331*BN)

<400>  49

Ser Thr Trp Ser Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H)

<400>  50

Ala His Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ A331*BN)

<400>  51

Ala His Trp Phe Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ F328*Q_ D329*G)

<400>  52

Ala His Trp Gln Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ F328*S)

<400>  53

Ala His Trp Ser Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  54
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ F328*S_ A331*BN)

<400>  54

Ala His Trp Ser Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A)

<400>  55

Ala Thr Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ A331*BN)

<400>  56

Ala Thr Trp Phe Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*W)

<400>  57

Ser Trp Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*V)

<400>  58

Ser Val Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*Y)

<400>  59

Ser Thr Trp Tyr Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*S_ D329*G)

<400>  60

Ser Thr Trp Ser Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (D329*G)

<400>  61

Ser Thr Trp Phe Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ F328*S_ A331*BN)

<400>  62

Ala Thr Trp Ser Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BL)

<400>  63

Ser Thr Trp Phe Asp Gly Gly Tyr Leu Thr 
1               5                   10  


<210>  64
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BK)

<400>  64

Ser Thr Trp Phe Asp Gly Gly Tyr Lys Thr 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BH)

<400>  65

Ser Thr Trp Phe Asp Gly Gly Tyr His Thr 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BF)

<400>  66

Ser Thr Trp Phe Asp Gly Gly Tyr Phe Thr 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (Y331*AW)

<400>  67

Ser Thr Trp Phe Asp Gly Gly Trp Ala Thr 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (D330*K)

<400>  68

Ser Thr Trp Phe Asp Lys Gly Tyr Ala Thr 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*R)

<400>  69

Ser Thr Trp Phe Asp Arg Gly Tyr Ala Thr 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*H)

<400>  70

Ser Thr Trp Phe Asp His Gly Tyr Ala Thr 
1               5                   10  


<210>  71
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*Q_ E329*S_ A331*BY)

<400>  71

Gly Leu Asp Gln Ser Gly Lys Gly Tyr Val 
1               5                   10  


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*T_ E329*N_ A331*BY)

<400>  72

Gly Leu Asp Thr Asn Gly Lys Gly Tyr Val 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*H_ E329*R_ A331*BY)

<400>  73

Gly Leu Asp His Arg Gly Lys Gly Tyr Val 
1               5                   10  


<210>  74
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E328*T_ E329*N_ A331*BV)

<400>  74

Phe Leu Asp Thr Asn Gly Lys Gly Val Val 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E328*Q_ E329*S_ A331*BV)

<400>  75

Phe Leu Asp Gln Ser Gly Lys Gly Val Val 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E328*H_ E329*R_ A331*BV)

<400>  76

Phe Leu Asp His Arg Gly Lys Gly Val Val 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E329*N_ A331*BV)

<400>  77

Phe Leu Asp Glu Asn Gly Lys Gly Val Val 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E329*N_ A331*BY)

<400>  78

Gly Leu Asp Glu Asn Gly Lys Gly Tyr Val 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D327*N_ Q328*H_ Q330*D)

<400>  79

Asp Phe Asn His Asn Asp Gly Glu Val Val 
1               5                   10  


<210>  80
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*T_ N329*D_ Q330*D)

<400>  80

Asp Phe Asp Thr Asp Asp Gly Glu Val Val 
1               5                   10  


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*S_ N329*T)

<400>  81

Asp Phe Asp Ser Thr Gln Gly Glu Val Val 
1               5                   10  


<210>  82
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*S_ N329*T_ Q330*D)

<400>  82

Asp Phe Asp Ser Thr Asp Gly Glu Val Val 
1               5                   10  


<210>  83
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*T_ N329*S)

<400>  83

Asp Phe Asp Thr Ser Gln Gly Glu Val Val 
1               5                   10  


<210>  84
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*H_ N329*D)

<400>  84

Asp Phe Asp His Asp Gln Gly Glu Val Val 
1               5                   10  


<210>  85
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*N_ N329*D_ Q330*D)

<400>  85

Asp Phe Asp Asn Asp Asp Gly Glu Val Val 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*E_ N329*D_ Q330*D)

<400>  86

Asp Phe Asp Glu Asp Asp Gly Glu Val Val 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (E328*H_ E329*N_ Y331*BI)

<400>  87

Leu Thr Asp His Asn Gly Arg Pro Ile Arg 
1               5                   10  


<210>  88
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (Y331*BI)

<400>  88

Leu Thr Asp Glu Glu Gly Arg Pro Ile Arg 
1               5                   10  


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (E329*D_ R331*S_ Y331*BI)

<400>  89

Leu Thr Asp Glu Asp Gly Ser Pro Ile Arg 
1               5                   10  


<210>  90
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (E329*D_ Y331*BI)

<400>  90

Leu Thr Asp Glu Asp Gly Arg Pro Ile Arg 
1               5                   10  


<210>  91
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*S)

<400>  91

Ser Ser Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  92
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (Y331*AE)

<400>  92

Ser Thr Trp Phe Asp Gly Gly Glu Ala Thr 
1               5                   10  


<210>  93
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (Y331*AD)

<400>  93

Ser Thr Trp Phe Asp Gly Gly Asp Ala Thr 
1               5                   10  


<210>  94
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (Y331*AA)

<400>  94

Ser Thr Trp Phe Asp Gly Gly Ala Ala Thr 
1               5                   10  


<210>  95
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*A)

<400>  95

Ser Thr Trp Ala Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  96
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (W327*T_ F328*H_ D329*G)

<400>  96

Ser Thr Thr His Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  97
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*N)

<400>  97

Asn Thr Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (Y331*AH)

<400>  98

Ser Thr Trp Phe Asp Gly Gly His Ala Thr 
1               5                   10  


<210>  99
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*E_ A331*BN)

<400>  99

Ser His Trp Glu Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ F328*E)

<400>  100

Ser His Trp Glu Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*D)

<400>  101

Asp Thr Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ W327*T_ F328*T_ D329*G)

<400>  102

Ser His Thr Thr Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  103
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ W327*T_ F328*H_ D329*G)

<400>  103

Ser His Thr His Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*H_ W327*D_ F328*T_ D329*G)

<400>  104

Ser His Asp Thr Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  105
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*I)

<400>  105

Ser Thr Trp Ile Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  106
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (D329*Q)

<400>  106

Ser Thr Trp Phe Gln Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  107
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (D329*P)

<400>  107

Ser Thr Trp Phe Pro Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  108
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ F328*E_ A331*BN)

<400>  108

Ala His Trp Glu Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  109
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (S325*A_ T326*H_ F328*E_ D329*G)

<400>  109

Ala His Trp Glu Gly Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  110
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (T326*Y)

<400>  110

Ser Tyr Trp Phe Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  111
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*W)

<400>  111

Ser Thr Trp Trp Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*V)

<400>  112

Ser Thr Trp Val Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  113
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (F328*T)

<400>  113

Ser Thr Trp Thr Asp Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (D329*E)

<400>  114

Ser Thr Trp Phe Glu Gly Gly Tyr Ala Thr 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BR)

<400>  115

Ser Thr Trp Phe Asp Gly Gly Tyr Arg Thr 
1               5                   10  


<210>  116
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BQ)

<400>  116

Ser Thr Trp Phe Asp Gly Gly Tyr Gln Thr 
1               5                   10  


<210>  117
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BN)

<400>  117

Ser Thr Trp Phe Asp Gly Gly Tyr Asn Thr 
1               5                   10  


<210>  118
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BG)

<400>  118

Ser Thr Trp Phe Asp Gly Gly Tyr Gly Thr 
1               5                   10  


<210>  119
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BE)

<400>  119

Ser Thr Trp Phe Asp Gly Gly Tyr Glu Thr 
1               5                   10  


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (A331*BD)

<400>  120

Ser Thr Trp Phe Asp Gly Gly Tyr Asp Thr 
1               5                   10  


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (Y331*AP)

<400>  121

Ser Thr Trp Phe Asp Gly Gly Pro Ala Thr 
1               5                   10  


<210>  122
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*S)

<400>  122

Ser Thr Trp Phe Asp Ser Gly Tyr Ala Thr 
1               5                   10  


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*N)

<400>  123

Ser Thr Trp Phe Asp Asn Gly Tyr Ala Thr 
1               5                   10  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*T)

<400>  124

Ser Thr Trp Phe Asp Thr Gly Tyr Ala Thr 
1               5                   10  


<210>  125
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 1 (G330*Y)

<400>  125

Ser Thr Trp Phe Asp Tyr Gly Tyr Ala Thr 
1               5                   10  


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ A330*BV)

<400>  126

Phe Leu Asp Glu Glu Gly Lys Gly Val Val 
1               5                   10  


<210>  127
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*Q_ E329*S_ A330*BV)

<400>  127

Gly Leu Asp Gln Ser Gly Lys Gly Val Val 
1               5                   10  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*Q_ E329*S)

<400>  128

Gly Leu Asp Gln Ser Gly Lys Gly Ala Val 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*H_ E329*T)

<400>  129

Gly Leu Asp His Thr Gly Lys Gly Ala Val 
1               5                   10  


<210>  130
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*T_ E329*N_ A330*BV)

<400>  130

Gly Leu Asp Thr Asn Gly Lys Gly Val Val 
1               5                   10  


<210>  131
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*T_ E329*N)

<400>  131

Gly Leu Asp Thr Asn Gly Lys Gly Ala Val 
1               5                   10  


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F)

<400>  132

Phe Leu Asp Glu Glu Gly Lys Gly Ala Val 
1               5                   10  


<210>  133
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*H_ E329*R)

<400>  133

Gly Leu Asp His Arg Gly Lys Gly Ala Val 
1               5                   10  


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E328*T_ E329*N)

<400>  134

Phe Leu Asp Thr Asn Gly Lys Gly Ala Val 
1               5                   10  


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E328*Q_ E329*S)

<400>  135

Phe Leu Asp Gln Ser Gly Lys Gly Ala Val 
1               5                   10  


<210>  136
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E328*H_ E329*R)

<400>  136

Phe Leu Asp His Arg Gly Lys Gly Ala Val 
1               5                   10  


<210>  137
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (G325*F_ E329*N)

<400>  137

Phe Leu Asp Glu Asn Gly Lys Gly Ala Val 
1               5                   10  


<210>  138
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E328*H_ E329*R_ A331*BV)

<400>  138

Gly Leu Asp His Arg Gly Lys Gly Val Val 
1               5                   10  


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E329*N_ A331*BV)

<400>  139

Gly Leu Asp Glu Asn Gly Lys Gly Val Val 
1               5                   10  


<210>  140
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (E329*N)

<400>  140

Gly Leu Asp Glu Asn Gly Lys Gly Ala Val 
1               5                   10  


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (A331*BY)

<400>  141

Gly Leu Asp Glu Glu Gly Lys Gly Tyr Val 
1               5                   10  


<210>  142
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 (A331*BV)

<400>  142

Gly Leu Asp Glu Glu Gly Lys Gly Val Val 
1               5                   10  


<210>  143
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7 - strat3-HF (Parental)

<400>  143

Gly Thr Asp Glu Glu Gly Lys Gly Ala Thr 
1               5                   10  


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7-HF (E329*N_ A331*BV)

<400>  144

Gly Thr Asp Glu Asn Gly Lys Gly Val Thr 
1               5                   10  


<210>  145
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7-HF (E329*N)

<400>  145

Gly Thr Asp Glu Asn Gly Lys Gly Ala Thr 
1               5                   10  


<210>  146
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7-HF (A331*BV)

<400>  146

Gly Thr Asp Glu Glu Gly Lys Gly Val Thr 
1               5                   10  


<210>  147
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7-HF (G325*F_ A331*BV)

<400>  147

Phe Thr Asp Glu Glu Gly Lys Gly Val Thr 
1               5                   10  


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 7-HF (G325*F)

<400>  148

Phe Thr Asp Glu Glu Gly Lys Gly Ala Thr 
1               5                   10  


<210>  149
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D325*A_ Q328*P_ N329*D)

<400>  149

Ala Phe Asp Pro Asp Gln Gly Glu Val Val 
1               5                   10  


<210>  150
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D325*A_ Q328*D_ N329*E_ Q330*D)

<400>  150

Ala Phe Asp Asp Glu Asp Gly Glu Val Val 
1               5                   10  


<210>  151
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D327*N_ Q328*D_ N329*E)

<400>  151

Asp Phe Asn Asp Glu Gln Gly Glu Val Val 
1               5                   10  


<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*E_ N329*E)

<400>  152

Asp Phe Asp Glu Glu Gln Gly Glu Val Val 
1               5                   10  


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D325*A_ Q328*E_ N329*D_ Q330*D)

<400>  153

Ala Phe Asp Glu Asp Asp Gly Glu Val Val 
1               5                   10  


<210>  154
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D325*A_ Q328*E_ N329*E)

<400>  154

Ala Phe Asp Glu Glu Gln Gly Glu Val Val 
1               5                   10  


<210>  155
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D325*A_ Q328*H_ N329*D)

<400>  155

Ala Phe Asp His Asp Gln Gly Glu Val Val 
1               5                   10  


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D325*A)

<400>  156

Ala Phe Asp Gln Asn Gln Gly Glu Val Val 
1               5                   10  


<210>  157
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (D325*A_ Q328*S_ N329*T_ Q330*D)

<400>  157

Ala Phe Asp Ser Thr Asp Gly Glu Val Val 
1               5                   10  


<210>  158
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*D_ N329*S)

<400>  158

Asp Phe Asp Asp Ser Gln Gly Glu Val Val 
1               5                   10  


<210>  159
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*D_ N329*E_ Q330*D)

<400>  159

Asp Phe Asp Asp Glu Asp Gly Glu Val Val 
1               5                   10  


<210>  160
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 (Q328*P_ N329*D)

<400>  160

Asp Phe Asp Pro Asp Gln Gly Glu Val Val 
1               5                   10  


<210>  161
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66 - strat3-HF (Parental)

<400>  161

Asp Thr Asp Gln Asn Gln Gly Glu Val Thr 
1               5                   10  


<210>  162
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66-HF (Q328*D_ N329*E_ Q330*D)

<400>  162

Asp Thr Asp Asp Glu Asp Gly Glu Val Thr 
1               5                   10  


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66-HF (D325*A_ Q328*D_ N329*E_ Q330*D)

<400>  163

Ala Thr Asp Asp Glu Asp Gly Glu Val Thr 
1               5                   10  


<210>  164
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66-HF (D325*A_ Q328*P_ N329*D)

<400>  164

Ala Thr Asp Pro Asp Gln Gly Glu Val Thr 
1               5                   10  


<210>  165
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66-HF (D325*A)

<400>  165

Ala Thr Asp Gln Asn Gln Gly Glu Val Thr 
1               5                   10  


<210>  166
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 66-HF (Q328*P_ N329*D)

<400>  166

Asp Thr Asp Pro Asp Gln Gly Glu Val Thr 
1               5                   10  


<210>  167
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (R331*S)

<400>  167

Leu Thr Asp Glu Glu Gly Ser Pro Tyr Arg 
1               5                   10  


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (E328*H_ E329*N)

<400>  168

Leu Thr Asp His Asn Gly Arg Pro Tyr Arg 
1               5                   10  


<210>  169
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (E329*D_  R331*S)

<400>  169

Leu Thr Asp Glu Asp Gly Ser Pro Tyr Arg 
1               5                   10  


<210>  170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (E329*D)

<400>  170

Leu Thr Asp Glu Asp Gly Arg Pro Tyr Arg 
1               5                   10  


<210>  171
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 151 (Y331*BQ)

<400>  171

Leu Thr Asp Glu Glu Gly Arg Pro Gln Arg 
1               5                   10  


<210>  172
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 19 (V325*A)

<400>  172

Ala Thr Trp Glu Asp Gly Lys Ser Glu Arg 
1               5                   10  


<210>  173
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 356 3A15 (Bacteria)

<400>  173

His Ile Asp Asn Gln Gly Tyr Glu Asn Leu 
1               5                   10  


<210>  174
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 2552 EQB (Yeast)

<400>  174

Val Asp Ile Asn Gly Lys Lys Val Lys 
1               5                   


<210>  175
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 53 3CIN (Bacteria)

<400>  175

Tyr Val Ser Phe Asn Gly Ala Thr Asp Glu 
1               5                   10  


<210>  176
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 47 1L4U (Lobster)

<400>  176

Gly Ile Ala Tyr Asp Gly Asn Leu Leu Lys 
1               5                   10  


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 5 2W3Y (Bacteria)

<400>  177

Phe Gln Asp Thr Ser Gly Asn Val Phe Tyr 
1               5                   10  


<210>  178
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 48 2HLC (Insect)

<400>  178

Ile Thr Leu Gln Asp Gln Arg Arg Val Trp 
1               5                   10  


<210>  179
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 28 1JJ2 (Archaea)

<400>  179

Val Glu Phe Glu Asp Gly Asp Arg Arg Leu 
1               5                   10  


<210>  180
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 82 3LYV (Pathogenic Bacteria)

<400>  180

Tyr Thr Asp Ser Glu Asp Gly Ala Thr Asn Ile 
1               5                   10      


<210>  181
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 3 1JCF (Bacteria)

<400>  181

Gly Ile Asp Leu Ser Thr Gly Leu Pro Arg Lys 
1               5                   10      


<210>  182
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 12 14-2

<400>  182

Asp Phe Thr Pro Lys Ala Lys Leu Gly Phe Gln Ile 
1               5                   10          


<210>  183
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 13_3

<400>  183

Val Leu Asp Asp Pro Ser Arg Glu Asn Glu Ala Asp Leu 
1               5                   10              


<210>  184
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 12_14

<400>  184

Asn Phe Thr Pro Lys Ala Lys Leu Gly Phe Glu Ile 
1               5                   10          


<210>  185
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 14_0

<400>  185

Gln Val His Glu Asp Ala Thr Lys Pro Tyr Gly Leu Ser Leu 
1               5                   10                  


<210>  186
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Template 11_14

<400>  186

Ala Pro Gln Ile Asn Pro His Ser Pro Lys Phe 
1               5                   10      


