                         SEQUENCE LISTING

<110>  Decibel Therapeutics, Inc.
 
<120>  COMPOSITIONS AND METHODS FOR PROMOTING HAIR CELL REGENERATION

<130>  51124-085WO3

<150>  US 63/109,420
<151>  2020-11-04

<150>  US 63/025,039
<151>  2020-05-14

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  502
<212>  DNA
<213>  Homo sapiens

<400>  1
aacatatcct ggtgtggagt aggggacgct gctctgacag aggctcgggg gcctgagctg       60

gctctgtgag ctggggagga ggcagacagc caggccttgt ctgcaagcag acctggcagc      120

attgggctgg ccgcccccca gggcctcctc ttcatgccca gtgaatgact caccttggca      180

cagacacaat gttcggggtg ggcacagtgc ctgcttcccg ccgcacccca gcccccctca      240

aatgccttcc gagaagccca ttgagcaggg ggcttgcatt gcaccccagc ctgacagcct      300

ggcatcttgg gataaaagca gcacagcccc ctaggggctg cccttgctgt gtggcgccac      360

cggcggtgga gaacaaggct ctattcagcc tgtgcccagg aaaggggatc aggggatgcc      420

caggcatgga cagtgggtgg caggggggga gaggagggct gtctgcttcc cagaagtcca      480

aggacacaaa tgggtgaggg ga                                               502


<210>  2
<211>  917
<212>  DNA
<213>  Homo sapiens

<400>  2
aggggtggcc agggaaacgg ggcgctgcag gaataaagac gagccagcac agccagctca       60

tgtgtaacgg ctttgtggag ctgtcaaggc ctggtctctg ggagagaggc acagggaggc      120

cagacaagga aggggtgacc tggagggaca gatccagggg ctaaagtcct gataaggcaa      180

gagagtgccg gccccctctt gccctatcag gacctccact gccacataga ggccatgatt      240

gacccttaga caaagggctg gtgtccaatc ccagccccca gccccagaac tccagggaat      300

gaatgggcag agagcaggaa tgtgggacat ctgtgttcaa gggaaggact ccaggagtct      360

gctgggaatg aggcctagta ggaaatgagg tggcccttga gggtacagaa caggttcatt      420

cttcgccaaa ttcccagcac cttgcaggca cttacagctg agtgagataa tgcctgggtt      480

atgaaatcaa aaagttggaa agcaggtcag aggtcatctg gtacagccct tccttccctt      540

tttttttttt ttttttgtga gacaaggtct ctctctgttg cccaggctgg agtggcgcaa      600

acacagctca ctgcagcctc aacctactgg gctcaagcaa tcctccagcc tcagcctccc      660

aaagtgctgg gattacaagc atgagccacc ccactcagcc ctttccttcc tttttaattg      720

atgcataata attgtaagta ttcatcatgg tccaaccaac cctttcttga cccaccttcc      780

tagagagagg gtcctcttgc ttcagcggtc agggccccag acccatggtc tggctccagg      840

taccacctgc ctcatgcagg agttggcgtg cccaggaagc tctgcctctg ggcacagtga      900

cctcagtggg gtgaggg                                                     917


<210>  3
<211>  179
<212>  DNA
<213>  Homo sapiens

<400>  3
gagctctccc catagctggg ctgcggccca accccacccc ctcaggctat gccagggggt       60

gttgccaggg gcacccgggc atcgccagtc tagcccactc cttcataaag ccctcgcatc      120

ccaggagcga gcagagccag agcaggttgg agaggagacg catcacctcc gctgctcgc       179


<210>  4
<211>  254
<212>  DNA
<213>  Homo sapiens

<400>  4
aggggtggcc agggaaacgg ggcgctgcag gaataaagac gagccagcac agccagctca       60

tgtgtaacgg ctttgtggag ctgtcaaggc ctggtctctg ggagagaggc acagggaggc      120

cagacaagga aggggtgacc tggagggaca gatccagggg ctaaagtcct gataaggcaa      180

gagagtgccg gccccctctt gccctatcag gacctccact gccacataga ggccatgatt      240

gacccttaga caaa                                                        254


<210>  5
<211>  254
<212>  DNA
<213>  Homo sapiens

<400>  5
aggccatgat tgacccttag acaaagggct ggtgtccaat cccagccccc agccccagaa       60

ctccagggaa tgaatgggca gagagcagga atgtgggaca tctgtgttca agggaaggac      120

tccaggagtc tgctgggaat gaggcctagt aggaaatgag gtggcccttg agggtacaga      180

acaggttcat tcttcgccaa attcccagca ccttgcaggc acttacagct gagtgagata      240

atgcctgggt tatg                                                        254


<210>  6
<211>  253
<212>  DNA
<213>  Homo sapiens

<400>  6
tgagtgagat aatgcctggg ttatgaaatc aaaaagttgg aaagcaggtc agaggtcatc       60

tggtacagcc cttccttccc tttttttttt ttttttttgt gagacaaggt ctctctctgt      120

tgcccaggct ggagtggcgc aaacacagct cactgcagcc tcaacctact gggctcaagc      180

aatcctccag cctcagcctc ccaaagtgct gggattacaa gcatgagcca ccccactcag      240

ccctttcctt cct                                                         253


<210>  7
<211>  231
<212>  DNA
<213>  Homo sapiens

<400>  7
caccccactc agccctttcc ttccttttta attgatgcat aataattgta agtattcatc       60

atggtccaac caaccctttc ttgacccacc ttcctagaga gagggtcctc ttgcttcagc      120

ggtcagggcc ccagacccat ggtctggctc caggtaccac ctgcctcatg caggagttgg      180

cgtgcccagg aagctctgcc tctgggcaca gtgacctcag tggggtgagg g               231


<210>  8
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8
aacatatcct ggtgtggagt aggggacgct gctctgacag aggctcgggg gcctgagctg       60

gctctgtgag ctggggagga ggcagacagc caggccttgt ctgcaagcag acctggcagc      120

attgggctgg ccgcccccca gggcctcctc ttcatgccca gtgaatgact caccttggca      180

cagacacaat gttcggggtg ggcacagtgc ctgcttcccg ccgcacccca gcccccctca      240

aatgccttcc gagaagccca ttgagcaggg ggcttgcatt gcaccccagc ctgacagcct      300

ggcatcttgg gataaaagca gcacagcccc ctaggggctg cccttgctgt gtggcgccac      360

cggcggtgga gaacaaggct ctattcagcc tgtgcccagg aaaggggatc aggggatgcc      420

caggcatgga cagtgggtgg caggggggga gaggagggct gtctgcttcc cagaagtcca      480

aggacacaaa tgggtgaggg gagagctctc cccatagctg ggctgcggcc caaccccacc      540

ccctcaggct atgccagggg gtgttgccag gggcacccgg gcatcgccag tctagcccac      600

tccttcataa agccctcgca tcccaggagc gagcagagcc agagcaggtt ggagaggaga      660

cgcatcacct ccgctgctcg c                                                681


<210>  9
<211>  2209
<212>  DNA
<213>  Homo sapiens

<400>  9
gagctcccac ctccctctct gtgctgggac tcacagaggg agacctcagg aggcagtctg       60

tccatcacat gtccaaatgc agagcatacc ctgggctggg cgcagtggcg cacaactgta      120

attccagcac tttgggaggc tgatgtggaa ggatcacttg agcccagaag ttctagacca      180

gcctgggcaa catggcaaga ccctatctct acaaaaaaag ttaaaaaatc agccacgtgt      240

ggtgacacac acctgtagtc ccagctattc aggaggctga ggtgagggga tcacttaagg      300

ctgggaggtt gaggctgcag tgagtcgtgg ttgcgccact gcactccagc ctgggcaaca      360

gtgagaccct gtctcaaaag acaaaaaaaa aaaaaaaaaa aaaaagaaca tatcctggtg      420

tggagtaggg gacgctgctc tgacagaggc tcgggggcct gagctggctc tgtgagctgg      480

ggaggaggca gacagccagg ccttgtctgc aagcagacct ggcagcattg ggctggccgc      540

cccccagggc ctcctcttca tgcccagtga atgactcacc ttggcacaga cacaatgttc      600

ggggtgggca cagtgcctgc ttcccgccgc accccagccc ccctcaaatg ccttccgaga      660

agcccattga gcagggggct tgcattgcac cccagcctga cagcctggca tcttgggata      720

aaagcagcac agccccctag gggctgccct tgctgtgtgg cgccaccggc ggtggagaac      780

aaggctctat tcagcctgtg cccaggaaag gggatcaggg gatgcccagg catggacagt      840

gggtggcagg gggggagagg agggctgtct gcttcccaga agtccaagga cacaaatggg      900

tgaggggact gggcagggtt ctgaccctgt gggaccagag tggagggcgt agatggacct      960

gaagtctcca gggacaacag ggcccaggtc tcaggctcct agttgggccc agtggctcca     1020

gcgtttccaa acccatccat ccccagaggt tcttcccatc tctccaggct gatgtgtggg     1080

aactcgagga aataaatctc cagtgggaga cggaggggtg gccagggaaa cggggcgctg     1140

caggaataaa gacgagccag cacagccagc tcatgtgtaa cggctttgtg gagctgtcaa     1200

ggcctggtct ctgggagaga ggcacaggga ggccagacaa ggaaggggtg acctggaggg     1260

acagatccag gggctaaagt cctgataagg caagagagtg ccggccccct cttgccctat     1320

caggacctcc actgccacat agaggccatg attgaccctt agacaaaggg ctggtgtcca     1380

atcccagccc ccagccccag aactccaggg aatgaatggg cagagagcag gaatgtggga     1440

catctgtgtt caagggaagg actccaggag tctgctggga atgaggccta gtaggaaatg     1500

aggtggccct tgagggtaca gaacaggttc attcttcgcc aaattcccag caccttgcag     1560

gcacttacag ctgagtgaga taatgcctgg gttatgaaat caaaaagttg gaaagcaggt     1620

cagaggtcat ctggtacagc ccttccttcc cttttttttt tttttttttg tgagacaagg     1680

tctctctctg ttgcccaggc tggagtggcg caaacacagc tcactgcagc ctcaacctac     1740

tgggctcaag caatcctcca gcctcagcct cccaaagtgc tgggattaca agcatgagcc     1800

accccactca gccctttcct tcctttttaa ttgatgcata ataattgtaa gtattcatca     1860

tggtccaacc aaccctttct tgacccacct tcctagagag agggtcctct tgcttcagcg     1920

gtcagggccc cagacccatg gtctggctcc aggtaccacc tgcctcatgc aggagttggc     1980

gtgcccagga agctctgcct ctgggcacag tgacctcagt ggggtgaggg gagctctccc     2040

catagctggg ctgcggccca accccacccc ctcaggctat gccagggggt gttgccaggg     2100

gcacccgggc atcgccagtc tagcccactc cttcataaag ccctcgcatc ccaggagcga     2160

gcagagccag agcaggttgg agaggagacg catcacctcc gctgctcgc                 2209


<210>  10
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 
1               5                   10                  15      


Gly Asp His His Arg Gln Pro Gln Pro His His Leu Pro Gln Pro Pro 
            20                  25                  30          


Pro Pro Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Glu His Pro Val 
        35                  40                  45              


Tyr Pro Pro Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp 
    50                  55                  60                  


Leu Ala Pro Thr Leu Gln Gly Ile Cys Thr Ala Arg Ala Ala Gln Tyr 
65                  70                  75                  80  


Leu Leu His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg 
                85                  90                  95      


Asp Glu Val Asp Gly Arg Gly Glu Leu Val Arg Arg Ser Ser Gly Gly 
            100                 105                 110         


Ala Ser Ser Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu 
        115                 120                 125             


Cys Lys Leu Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg 
    130                 135                 140                 


Gln Arg Ala Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg 
145                 150                 155                 160 


Arg Leu Ala Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn 
                165                 170                 175     


His Ala Phe Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp 
            180                 185                 190         


Lys Lys Leu Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile 
        195                 200                 205             


Asn Ala Leu Ser Glu Leu Leu Gln Thr Pro Ser Gly Gly Glu Gln Pro 
    210                 215                 220                 


Pro Pro Pro Pro Ala Ser Cys Lys Ser Asp His His His Leu Arg Thr 
225                 230                 235                 240 


Ala Ala Ser Tyr Glu Gly Gly Ala Gly Asn Ala Thr Ala Ala Gly Ala 
                245                 250                 255     


Gln Gln Ala Ser Gly Gly Ser Gln Arg Pro Thr Pro Pro Gly Ser Cys 
            260                 265                 270         


Arg Thr Arg Phe Ser Ala Pro Ala Ser Ala Gly Gly Tyr Ser Val Gln 
        275                 280                 285             


Leu Asp Ala Leu His Phe Ser Thr Phe Glu Asp Ser Ala Leu Thr Ala 
    290                 295                 300                 


Met Met Ala Gln Lys Asn Leu Ser Pro Ser Leu Pro Gly Ser Ile Leu 
305                 310                 315                 320 


Gln Pro Val Gln Glu Glu Asn Ser Lys Thr Ser Pro Arg Ser His Arg 
                325                 330                 335     


Ser Asp Gly Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu 
            340                 345                 350         


Ala Ser 
        


<210>  11
<211>  1062
<212>  DNA
<213>  Homo sapiens

<400>  11
atgtcccgcc tgctgcatgc agaagagtgg gctgaagtga aggagttggg agaccaccat       60

cgccagcccc agccgcatca tctcccgcaa ccgccgccgc cgccgcagcc acctgcaact      120

ttgcaggcga gagagcatcc cgtctacccg cctgagctgt ccctcctgga cagcaccgac      180

ccacgcgcct ggctggctcc cactttgcag ggcatctgca cggcacgcgc cgcccagtat      240

ttgctacatt ccccggagct gggtgcctca gaggccgctg cgccccggga cgaggtggac      300

ggccgggggg agctggtaag gaggagcagc ggcggtgcca gcagcagcaa gagccccggg      360

ccggtgaaag tgcgggaaca gctgtgcaag ctgaaaggcg gggtggtggt agacgagctg      420

ggctgcagcc gccaacgggc cccttccagc aaacaggtga atggggtgca gaagcagaga      480

cggctagcag ccaacgccag ggagcggcgc aggatgcatg ggctgaacca cgccttcgac      540

cagctgcgca atgttatccc gtcgttcaac aacgacaaga agctgtccaa atatgagacc      600

ctgcagatgg cccaaatcta catcaacgcc ttgtccgagc tgctacaaac gcccagcgga      660

ggggaacagc caccgccgcc tccagcctcc tgcaaaagcg accaccacca ccttcgcacc      720

gcggcctcct atgaaggggg cgcgggcaac gcgaccgcag ctggggctca gcaggcttcc      780

ggagggagcc agcggccgac cccgcccggg agttgccgga ctcgcttctc agccccagct      840

tctgcgggag ggtactcggt gcagctggac gctctgcact tctcgacttt cgaggacagc      900

gccctgacag cgatgatggc gcaaaagaat ttgtctcctt ctctccccgg gagcatcttg      960

cagccagtgc aggaggaaaa cagcaaaact tcgcctcggt cccacagaag cgacggggaa     1020

ttttcccccc attcccatta cagtgactcg gatgaggcaa gt                        1062


<210>  12
<211>  351
<212>  PRT
<213>  Mus musculus

<400>  12

Met Ser Arg Leu Leu His Ala Glu Glu Trp Ala Glu Val Lys Glu Leu 
1               5                   10                  15      


Gly Asp His His Arg His Pro Gln Pro His His Val Pro Pro Leu Thr 
            20                  25                  30          


Pro Gln Pro Pro Ala Thr Leu Gln Ala Arg Asp Leu Pro Val Tyr Pro 
        35                  40                  45              


Ala Glu Leu Ser Leu Leu Asp Ser Thr Asp Pro Arg Ala Trp Leu Thr 
    50                  55                  60                  


Pro Thr Leu Gln Gly Leu Cys Thr Ala Arg Ala Ala Gln Tyr Leu Leu 
65                  70                  75                  80  


His Ser Pro Glu Leu Gly Ala Ser Glu Ala Ala Ala Pro Arg Asp Glu 
                85                  90                  95      


Ala Asp Ser Gln Gly Glu Leu Val Arg Arg Ser Gly Cys Gly Gly Leu 
            100                 105                 110         


Ser Lys Ser Pro Gly Pro Val Lys Val Arg Glu Gln Leu Cys Lys Leu 
        115                 120                 125             


Lys Gly Gly Val Val Val Asp Glu Leu Gly Cys Ser Arg Gln Arg Ala 
    130                 135                 140                 


Pro Ser Ser Lys Gln Val Asn Gly Val Gln Lys Gln Arg Arg Leu Ala 
145                 150                 155                 160 


Ala Asn Ala Arg Glu Arg Arg Arg Met His Gly Leu Asn His Ala Phe 
                165                 170                 175     


Asp Gln Leu Arg Asn Val Ile Pro Ser Phe Asn Asn Asp Lys Lys Leu 
            180                 185                 190         


Ser Lys Tyr Glu Thr Leu Gln Met Ala Gln Ile Tyr Ile Asn Ala Leu 
        195                 200                 205             


Ser Glu Leu Leu Gln Thr Pro Asn Val Gly Glu Gln Pro Pro Pro Pro 
    210                 215                 220                 


Thr Ala Ser Cys Lys Asn Asp His His His Leu Arg Thr Ala Ser Ser 
225                 230                 235                 240 


Tyr Glu Gly Gly Ala Gly Ala Ser Ala Val Ala Gly Ala Gln Pro Ala 
                245                 250                 255     


Pro Gly Gly Gly Pro Arg Pro Thr Pro Pro Gly Pro Cys Arg Thr Arg 
            260                 265                 270         


Phe Ser Gly Pro Ala Ser Ser Gly Gly Tyr Ser Val Gln Leu Asp Ala 
        275                 280                 285             


Leu His Phe Pro Ala Phe Glu Asp Arg Ala Leu Thr Ala Met Met Ala 
    290                 295                 300                 


Gln Lys Asp Leu Ser Pro Ser Leu Pro Gly Gly Ile Leu Gln Pro Val 
305                 310                 315                 320 


Gln Glu Asp Asn Ser Lys Thr Ser Pro Arg Ser His Arg Ser Asp Gly 
                325                 330                 335     


Glu Phe Ser Pro His Ser His Tyr Ser Asp Ser Asp Glu Ala Ser 
            340                 345                 350     


<210>  13
<211>  1053
<212>  DNA
<213>  Mus musculus

<400>  13
atgtcccgcc tgctgcatgc agaagagtgg gctgaggtaa aagagttggg ggaccaccat       60

cgccatcccc agccgcacca cgtcccgccg ctgacgccac agccacctgc taccctgcag      120

gcgagagacc ttcccgtcta cccggcagaa ctgtccctcc tggatagcac cgacccacgc      180

gcctggctga ctcccacttt gcagggcctc tgcacggcac gcgccgccca gtatctgctg      240

cattctcccg agctgggtgc ctccgaggcc gcggcgcccc gggacgaggc tgacagccag      300

ggtgagctgg taaggagaag cggctgtggc ggcctcagca agagccccgg gcccgtcaaa      360

gtacgggaac agctgtgcaa gctgaagggt ggggttgtag tggacgagct tggctgcagc      420

cgccagcgag ccccttccag caaacaggtg aatggggtac agaagcaaag gaggctggca      480

gcaaacgcaa gggaacggcg caggatgcac gggctgaacc acgccttcga ccagctgcgc      540

aacgttatcc cgtccttcaa caacgacaag aagctgtcca aatatgagac cctacagatg      600

gcccagatct acatcaacgc tctgtcggag ttgctgcaga ctcccaatgt cggagagcaa      660

ccgccgccgc ccacagcttc ctgcaaaaat gaccaccatc accttcgcac cgcctcctcc      720

tatgaaggag gtgcgggcgc ctctgcggta gctggggctc agccagcccc gggagggggc      780

ccgagaccta ccccgcccgg gccttgccgg actcgcttct caggcccagc ttcctctggg      840

ggttactcgg tgcagctgga cgctttgcac ttcccagcct tcgaggacag ggccctaaca      900

gcgatgatgg cacagaagga cctgtcgcct tcgctgcccg ggggcatcct gcagcctgta      960

caggaggaca acagcaaaac atctcccaga tcccacagaa gtgacggaga gttttccccc     1020

cactctcatt acagtgactc tgatgaggcc agt                                  1053


<210>  14
<211>  6988
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc ggcgcgccac accggtgaac atatcctggt      240

gtggagtagg ggacgctgct ctgacagagg ctcgggggcc tgagctggct ctgtgagctg      300

gggaggaggc agacagccag gccttgtctg caagcagacc tggcagcatt gggctggccg      360

ccccccaggg cctcctcttc atgcccagtg aatgactcac cttggcacag acacaatgtt      420

cggggtgggc acagtgcctg cttcccgccg caccccagcc cccctcaaat gccttccgag      480

aagcccattg agcagggggc ttgcattgca ccccagcctg acagcctggc atcttgggat      540

aaaagcagca cagcccccta ggggctgccc ttgctgtgtg gcgccaccgg cggtggagaa      600

caaggctcta ttcagcctgt gcccaggaaa ggggatcagg ggatgcccag gcatggacag      660

tgggtggcag ggggggagag gagggctgtc tgcttcccag aagtccaagg acacaaatgg      720

gtgaggggag agctctcccc atagctgggc tgcggcccaa ccccaccccc tcaggctatg      780

ccagggggtg ttgccagggg cacccgggca tcgccagtct agcccactcc ttcataaagc      840

cctcgcatcc caggagcgag cagagccaga gcaggttgga gaggagacgc atcacctccg      900

ctgctcgccc gcggccgcgc caccatgtcc cgcctgctgc atgcagaaga gtgggctgaa      960

gtgaaggagt tgggagacca ccatcgccag ccccagccgc atcatctccc gcaaccgccg     1020

ccgccgccgc agccacctgc aactttgcag gcgagagagc atcccgtcta cccgcctgag     1080

ctgtccctcc tggacagcac cgacccacgc gcctggctgg ctcccacttt gcagggcatc     1140

tgcacggcac gcgccgccca gtatttgcta cattccccgg agctgggtgc ctcagaggcc     1200

gctgcgcccc gggacgaggt ggacggccgg ggggagctgg taaggaggag cagcggcggt     1260

gccagcagca gcaagagccc cgggccggtg aaagtgcggg aacagctgtg caagctgaaa     1320

ggcggggtgg tggtagacga gctgggctgc agccgccaac gggccccttc cagcaaacag     1380

gtgaatgggg tgcagaagca gagacggcta gcagccaacg ccagggagcg gcgcaggatg     1440

catgggctga accacgcctt cgaccagctg cgcaatgtta tcccgtcgtt caacaacgac     1500

aagaagctgt ccaaatatga gaccctgcag atggcccaaa tctacatcaa cgccttgtcc     1560

gagctgctac aaacgcccag cggaggggaa cagccaccgc cgcctccagc ctcctgcaaa     1620

agcgaccacc accaccttcg caccgcggcc tcctatgaag ggggcgcggg caacgcgacc     1680

gcagctgggg ctcagcaggc ttccggaggg agccagcggc cgaccccgcc cgggagttgc     1740

cggactcgct tctcagcccc agcttctgcg ggagggtact cggtgcagct ggacgctctg     1800

cacttctcga ctttcgagga cagcgccctg acagcgatga tggcgcaaaa gaatttgtct     1860

ccttctctcc ccgggagcat cttgcagcca gtgcaggagg aaaacagcaa aacttcgcct     1920

cggtcccaca gaagcgacgg ggaattttcc ccccattccc attacagtga ctcggatgag     1980

gcaagtacgc gtggaagcgg agctactaac ttcagcctgc tgaagcaggc tggcgacgtg     2040

gaggagaacc ctggacctat gccagagcca gcgaagtctg ctcccgcccc gaaaaagggc     2100

tccaagaagg cggtgactaa ggcgcagaag aaaggcggca agaagcgcaa gcgcagccgc     2160

aaggagagct attccatcta tgtgtacaag gttctgaagc aggtccaccc tgacaccggc     2220

atttcgtcca aggccatggg catcatgaat tcgtttgtga acgacatttt cgagcgcatc     2280

gcaggtgagg cttcccgcct ggcgcattac aacaagcgct cgaccatcac ctccagggag     2340

atccagacgg ccgtgcgcct gctgctgcct ggggagttgg ccaagcacgc cgtgtccgag     2400

ggtactaagg ccatcaccaa gtacaccagc gctaaggatc caccggtcgc caccatggtg     2460

agcaagggcg aggagctgtt caccggggtg gtgcccatcc tggtcgagct ggacggcgac     2520

gtaaacggcc acaagttcag cgtgtccggc gagggcgagg gcgatgccac ctacggcaag     2580

ctgaccctga agttcatctg caccaccggc aagctgcccg tgccctggcc caccctcgtg     2640

accaccctga cctacggcgt gcagtgcttc agccgctacc ccgaccacat gaagcagcac     2700

gacttcttca agtccgccat gcccgaaggc tacgtccagg agcgcaccat cttcttcaag     2760

gacgacggca actacaagac ccgcgccgag gtgaagttcg agggcgacac cctggtgaac     2820

cgcatcgagc tgaagggcat cgacttcaag gaggacggca acatcctggg gcacaagctg     2880

gagtacaact acaacagcca caacgtctat atcatggccg acaagcagaa gaacggcatc     2940

aaggtgaact tcaagatccg ccacaacatc gaggacggca gcgtgcagct cgccgaccac     3000

taccagcaga acacccccat cggcgacggc cccgtgctgc tgcccgacaa ccactacctg     3060

agcacccagt ccgccctgag caaagacccc aacgagaagc gcgatcacat ggtcctgctg     3120

gagttcgtga ccgccgccgg gatcactctc ggcatggacg agctgtacaa gtaataagct     3180

tggatccaat caacctctgg attacaaaat ttgtgaaaga ttgactggta ttcttaacta     3240

tgttgctcct tttacgctat gtggatacgc tgctttaatg cctttgtatc atgctattgc     3300

ttcccgtatg gctttcattt tctcctcctt gtataaatcc tggttgctgt ctctttatga     3360

ggagttgtgg cccgttgtca ggcaacgtgg cgtggtgtgc actgtgtttg ctgacgcaac     3420

ccccactggt tggggcattg ccaccacctg tcagctcctt tccgggactt tcgctttccc     3480

cctccctatt gccacggcgg aactcatcgc cgcctgcctt gcccgctgct ggacaggggc     3540

tcggctgttg ggcactgaca attccgtggt gttgtcgggg aaatcatcgt cctttccttg     3600

gctgctcgcc tgtgttgcca cctggattct gcgcgggacg tccttctgct acgtcccttc     3660

ggccctcaat ccagcggacc ttccttcccg cggcctgctg ccggctctgc ggcctcttcc     3720

gcgtcttcga gatctgcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc     3780

tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat     3840

gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg     3900

caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga ctcgagttaa     3960

gggcgaattc ccgataagga tcttcctaga gcatggctac gtagataagt agcatggcgg     4020

gttaatcatt aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc     4080

tcgctcgctc actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc     4140

ggcctcagtg agcgagcgag cgcgcagcct taattaacct aattcactgg ccgtcgtttt     4200

acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc     4260

ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt     4320

gcgcagcctg aatggcgaat gggacgcgcc ctgtagcggc gcattaagcg cggcgggtgt     4380

ggtggttacg cgcagcgtga ccgctacact tgccagcgcc ctagcgcccg ctcctttcgc     4440

tttcttccct tcctttctcg ccacgttcgc cggctttccc cgtcaagctc taaatcgggg     4500

gctcccttta gggttccgat ttagtgcttt acggcacctc gaccccaaaa aacttgatta     4560

gggtgatggt tcacgtagtg ggccatcgcc ctgatagacg gtttttcgcc ctttgacgtt     4620

ggagtccacg ttctttaata gtggactctt gttccaaact ggaacaacac tcaaccctat     4680

ctcggtctat tcttttgatt tataagggat tttgccgatt tcggcctatt ggttaaaaaa     4740

tgagctgatt taacaaaaat ttaacgcgaa ttttaacaaa atattaacgc ttacaattta     4800

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     4860

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     4920

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     4980

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     5040

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     5100

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     5160

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     5220

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     5280

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     5340

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     5400

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     5460

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     5520

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     5580

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag     5640

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta     5700

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     5760

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt     5820

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     5880

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     5940

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     6000

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     6060

tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag     6120

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     6180

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     6240

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     6300

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     6360

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     6420

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     6480

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     6540

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     6600

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt     6660

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag     6720

gaagcggaag agcgcccaat acgcaaaccg cctctccccg cgcgttggcc gattcattaa     6780

tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat     6840

gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc ggctcgtatg     6900

ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga ccatgattac     6960

gccagattta attaaggcct taattagg                                        6988


<210>  15
<211>  5751
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  15
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc ggcgcgccac accggtgaac atatcctggt      240

gtggagtagg ggacgctgct ctgacagagg ctcgggggcc tgagctggct ctgtgagctg      300

gggaggaggc agacagccag gccttgtctg caagcagacc tggcagcatt gggctggccg      360

ccccccaggg cctcctcttc atgcccagtg aatgactcac cttggcacag acacaatgtt      420

cggggtgggc acagtgcctg cttcccgccg caccccagcc cccctcaaat gccttccgag      480

aagcccattg agcagggggc ttgcattgca ccccagcctg acagcctggc atcttgggat      540

aaaagcagca cagcccccta ggggctgccc ttgctgtgtg gcgccaccgg cggtggagaa      600

caaggctcta ttcagcctgt gcccaggaaa ggggatcagg ggatgcccag gcatggacag      660

tgggtggcag ggggggagag gagggctgtc tgcttcccag aagtccaagg acacaaatgg      720

gtgaggggag agctctcccc atagctgggc tgcggcccaa ccccaccccc tcaggctatg      780

ccagggggtg ttgccagggg cacccgggca tcgccagtct agcccactcc ttcataaagc      840

cctcgcatcc caggagcgag cagagccaga gcaggttgga gaggagacgc atcacctccg      900

ctgctcgccc gcggccgcgc caccatgtcc cgcctgctgc atgcagaaga gtgggctgaa      960

gtgaaggagt tgggagacca ccatcgccag ccccagccgc atcatctccc gcaaccgccg     1020

ccgccgccgc agccacctgc aactttgcag gcgagagagc atcccgtcta cccgcctgag     1080

ctgtccctcc tggacagcac cgacccacgc gcctggctgg ctcccacttt gcagggcatc     1140

tgcacggcac gcgccgccca gtatttgcta cattccccgg agctgggtgc ctcagaggcc     1200

gctgcgcccc gggacgaggt ggacggccgg ggggagctgg taaggaggag cagcggcggt     1260

gccagcagca gcaagagccc cgggccggtg aaagtgcggg aacagctgtg caagctgaaa     1320

ggcggggtgg tggtagacga gctgggctgc agccgccaac gggccccttc cagcaaacag     1380

gtgaatgggg tgcagaagca gagacggcta gcagccaacg ccagggagcg gcgcaggatg     1440

catgggctga accacgcctt cgaccagctg cgcaatgtta tcccgtcgtt caacaacgac     1500

aagaagctgt ccaaatatga gaccctgcag atggcccaaa tctacatcaa cgccttgtcc     1560

gagctgctac aaacgcccag cggaggggaa cagccaccgc cgcctccagc ctcctgcaaa     1620

agcgaccacc accaccttcg caccgcggcc tcctatgaag ggggcgcggg caacgcgacc     1680

gcagctgggg ctcagcaggc ttccggaggg agccagcggc cgaccccgcc cgggagttgc     1740

cggactcgct tctcagcccc agcttctgcg ggagggtact cggtgcagct ggacgctctg     1800

cacttctcga ctttcgagga cagcgccctg acagcgatga tggcgcaaaa gaatttgtct     1860

ccttctctcc ccgggagcat cttgcagcca gtgcaggagg aaaacagcaa aacttcgcct     1920

cggtcccaca gaagcgacgg ggaattttcc ccccattccc attacagtga ctcggatgag     1980

gcaagttaga agcttggatc caatcaacct ctggattaca aaatttgtga aagattgact     2040

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     2100

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg     2160

ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg     2220

tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg     2280

actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc     2340

tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaaatca     2400

tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc     2460

tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct     2520

ctgcggcctc ttccgcgtct tcgagatctg cctcgactgt gccttctagt tgccagccat     2580

ctgttgtttg cccctccccc gtgccttcct tgaccctgga aggtgccact cccactgtcc     2640

tttcctaata aaatgaggaa attgcatcgc attgtctgag taggtgtcat tctattctgg     2700

ggggtggggt ggggcaggac agcaaggggg aggattggga agacaatagc aggcatgctg     2760

gggactcgag ttaagggcga attcccgata aggatcttcc tagagcatgg ctacgtagat     2820

aagtagcatg gcgggttaat cattaactac aaggaacccc tagtgatgga gttggccact     2880

ccctctctgc gcgctcgctc gctcactgag gccgggcgac caaaggtcgc ccgacgcccg     2940

ggctttgccc gggcggcctc agtgagcgag cgagcgcgca gccttaatta acctaattca     3000

ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc     3060

cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg caccgatcgc     3120

ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag cggcgcatta     3180

agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag cgccctagcg     3240

cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt tccccgtcaa     3300

gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca cctcgacccc     3360

aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata gacggttttt     3420

cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca aactggaaca     3480

acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc gatttcggcc     3540

tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa caaaatatta     3600

acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct atttgtttat     3660

ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga taaatgcttc     3720

aataatattg aaaaaggaag agtatgagcc atattcaacg ggaaacgtcg aggccgcgat     3780

taaattccaa catggatgct gatttatatg ggtataaatg ggctcgcgat aatgtcgggc     3840

aatcaggtgc gacaatctat cgcttgtatg ggaagcccga tgcgccagag ttgtttctga     3900

aacatggcaa aggtagcgtt gccaatgatg ttacagatga gatggtcaga ctaaactggc     3960

tgacggaatt tatgcctctt ccgaccatca agcattttat ccgtactcct gatgatgcat     4020

ggttactcac cactgcgatc cccggaaaaa cagcattcca ggtattagaa gaatatcctg     4080

attcaggtga aaatattgtt gatgcgctgg cagtgttcct gcgccggttg cattcgattc     4140

ctgtttgtaa ttgtcctttt aacagcgatc gcgtatttcg tcttgctcag gcgcaatcac     4200

gaatgaataa cggtttggtt gatgcgagtg attttgatga cgagcgtaat ggctggcctg     4260

ttgaacaagt ctggaaagaa atgcataaac ttttgccatt ctcaccggat tcagtcgtca     4320

ctcatggtga tttctcactt gataacctta tttttgacga ggggaaatta ataggttgta     4380

ttgatgttgg acgagtcgga atcgcagacc gataccagga tcttgccatc ctatggaact     4440

gcctcggtga gttttctcct tcattacaga aacggctttt tcaaaaatat ggtattgata     4500

atcctgatat gaataaattg cagtttcatt tgatgctcga tgagtttttc taactgtcag     4560

accaagttta ctcatatata ctttagattg atttaaaact tcatttttaa tttaaaagga     4620

tctaggtgaa gatccttttt gataatctca tgaccaaaat cccttaacgt gagttttcgt     4680

tccactgagc gtcagacccc gtagaaaaga tcaaaggatc ttcttgagat cctttttttc     4740

tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct accagcggtg gtttgtttgc     4800

cggatcaaga gctaccaact ctttttccga aggtaactgg cttcagcaga gcgcagatac     4860

caaatactgt tcttctagtg tagccgtagt taggccacca cttcaagaac tctgtagcac     4920

cgcctacata cctcgctctg ctaatcctgt taccagtggc tgctgccagt ggcgataagt     4980

cgtgtcttac cgggttggac tcaagacgat agttaccgga taaggcgcag cggtcgggct     5040

gaacgggggg ttcgtgcaca cagcccagct tggagcgaac gacctacacc gaactgagat     5100

acctacagcg tgagctatga gaaagcgcca cgcttcccga agggagaaag gcggacaggt     5160

atccggtaag cggcagggtc ggaacaggag agcgcacgag ggagcttcca gggggaaacg     5220

cctggtatct ttatagtcct gtcgggtttc gccacctctg acttgagcgt cgatttttgt     5280

gatgctcgtc aggggggcgg agcctatgga aaaacgccag caacgcggcc tttttacggt     5340

tcctggcctt ttgctggcct tttgctcaca tgttctttcc tgcgttatcc cctgattctg     5400

tggataaccg tattaccgcc tttgagtgag ctgataccgc tcgccgcagc cgaacgaccg     5460

agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc aatacgcaaa ccgcctctcc     5520

ccgcgcgttg gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg     5580

gcagtgagcg caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac     5640

actttatgct tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag     5700

gaaacagcta tgaccatgat tacgccagat ttaattaagg ccttaattag g              5751


<210>  16
<211>  548
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  16
gatccaatca acctctggat tacaaaattt gtgaaagatt gactggtatt cttaactatg       60

ttgctccttt tacgctatgt ggatacgctg ctttaatgcc tttgtatcat gctattgctt      120

cccgtatggc tttcattttc tcctccttgt ataaatcctg gttgctgtct ctttatgagg      180

agttgtggcc cgttgtcagg caacgtggcg tggtgtgcac tgtgtttgct gacgcaaccc      240

ccactggttg gggcattgcc accacctgtc agctcctttc cgggactttc gctttccccc      300

tccctattgc cacggcggaa ctcatcgccg cctgccttgc ccgctgctgg acaggggctc      360

ggctgttggg cactgacaat tccgtggtgt tgtcggggaa atcatcgtcc tttccttggc      420

tgctcgcctg tgttgccacc tggattctgc gcgggacgtc cttctgctac gtcccttcgg      480

ccctcaatcc agcggacctt ccttcccgcg gcctgctgcc ggctctgcgg cctcttccgc      540

gtcttcga                                                               548


<210>  17
<211>  425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  17
aatcaacctc tggattacaa aatttgtgaa agattgactg gtattcttaa ctatgttgct       60

ccttttacgc tatgtggata cgctgcttta atgcctttgt atcatgctat tgcttcccgt      120

atggctttca ttttctcctc cttgtataaa tcctggttag ttcttgccac ggcggaactc      180

atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc      240

gtggtgttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat ctagctttat      300

ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt ataagctgca ataaacaagt      360

taacaacaac aattgcattc attttatgtt tcaggttcag ggggagatgt gggaggtttt      420

ttaaa                                                                  425


