                               SEQUENCE LISTING

<110> CURIE CO. INC.
 
<120> TRANSGLUTAMINASE VARIANTS AND APPLICATIONS OF USE THEREOF

<130> 12527.006WO1

<140> PCT/US2021/032217
<141> 2021-05-13

<150> 63/074,288
<151> 2020-09-03

<150> 63/024,398
<151> 2020-05-13

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 331
<212> PRT
<213> Streptomyces mobaraensis

<400> 1
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 2
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 3
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


Val Val Tyr Glu Ser Lys Phe Arg Asn Trp Ala Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 4
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 4
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Met Gly Ser Leu Gly Ala Met 
        275                 280                 285             


Thr Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 5
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Glu Gly Ser Leu Gly Ala Met 
        275                 280                 285             


Val Val Tyr Glu Ser Lys Phe Arg Asn Trp Lys Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 6
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Asp Leu Gly Ala Met 
        275                 280                 285             


Leu Val Tyr Glu Ser Lys Phe Arg Asn Trp Lys Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 7
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Glu Gly Ser Leu Gly Ala Met 
        275                 280                 285             


Ile Val Tyr Glu Ser Lys Phe Arg Asn Trp Lys Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 8
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Lys Ala Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 9
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Gln Gly Pro Leu Gly Ala Met 
        275                 280                 285             


Glu Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 10
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Lys Ala Pro Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 11
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Arg Ala Glu Leu Gly Ala Met 
        275                 280                 285             


Gln Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 12
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ala Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 13
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Glu Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 14
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Lys Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 15
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 16
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ala Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 17
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Lys Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 18
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ala Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 19
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Glu Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 20
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Lys Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 21
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ala Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 22
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ala Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 23
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Glu Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 24
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Lys Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 25
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 25
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 26
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asp Ala Ala Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Val Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 27
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Gly Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Glu Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 28
<211> 331
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Asp Pro Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro 
                325                 330     


<210> 29
<211> 339
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Asp Ser Asp Asp Arg Val Thr Pro Pro Ala Glu Pro Leu Asp Arg Met 
1               5                   10                  15      


Pro Asp Pro Tyr Arg Pro Ser Tyr Gly Arg Ala Glu Thr Val Val Asn 
            20                  25                  30          


Asn Tyr Ile Arg Lys Trp Gln Gln Val Tyr Ser His Arg Asp Gly Arg 
        35                  40                  45              


Lys Gln Gln Met Thr Glu Glu Gln Arg Glu Trp Leu Ser Tyr Gly Cys 
    50                  55                  60                  


Val Gly Val Thr Trp Val Asn Ser Gly Gln Tyr Pro Thr Asn Arg Leu 
65                  70                  75                  80  


Ala Phe Ala Ser Phe Asp Glu Asp Arg Phe Lys Asn Glu Leu Lys Asn 
                85                  90                  95      


Gly Arg Pro Arg Ser Gly Glu Thr Arg Ala Glu Phe Glu Gly Arg Val 
            100                 105                 110         


Ala Lys Glu Ser Phe Asp Glu Glu Lys Gly Phe Gln Arg Ala Arg Glu 
        115                 120                 125             


Val Ala Ser Val Met Asn Arg Ala Leu Glu Asn Ala His Asp Glu Ser 
    130                 135                 140                 


Ala Tyr Leu Asp Asn Leu Lys Lys Glu Leu Ala Asn Gly Asn Asp Ala 
145                 150                 155                 160 


Leu Arg Asn Glu Asp Ala Arg Ser Pro Phe Tyr Ser Ala Leu Arg Asn 
                165                 170                 175     


Thr Pro Ser Phe Lys Glu Arg Asn Gly Gly Asn His Asp Pro Ser Arg 
            180                 185                 190         


Met Lys Ala Val Ile Tyr Ser Lys His Phe Trp Ser Gly Gln Asp Arg 
        195                 200                 205             


Ser Ser Ser Ala Asp Lys Arg Lys Tyr Gly Asp Pro Asp Ala Phe Arg 
    210                 215                 220                 


Pro Ala Pro Gly Thr Gly Leu Val Asp Met Ser Arg Asp Arg Asn Ile 
225                 230                 235                 240 


Pro Arg Ser Pro Thr Ser Pro Gly Glu Gly Phe Val Asn Phe Asp Tyr 
                245                 250                 255     


Gly Trp Phe Gly Ala Gln Thr Glu Ala Asp Ala Asp Lys Thr Val Trp 
            260                 265                 270         


Thr His Gly Asn His Tyr His Ala Pro Asn Gly Ser Leu Gly Ala Met 
        275                 280                 285             


His Val Tyr Glu Ser Lys Phe Arg Asn Trp Ser Glu Gly Tyr Ser Asp 
    290                 295                 300                 


Phe Asp Arg Gly Ala Tyr Val Ile Thr Phe Ile Pro Lys Ser Trp Asn 
305                 310                 315                 320 


Thr Ala Pro Asp Lys Val Lys Gln Gly Trp Pro Leu Glu His His His 
                325                 330                 335     


His His His 
            


<210> 30
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      His tag


<220>
<221> SITE
<222> (1)..(8)
<223> This sequence may encompass 6-8 residues

<400> 30
His His His His His His His His 
1               5               


<210> 31
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Pro Lys Glu Lys 
1               


