                               SEQUENCE LISTING

<110> KORRO BIO, INC.
 
<120> METHODS AND COMPOSITIONS FOR THE ADAR-MEDIATED EDITING OF 
      TRANSMEMBRANE CHANNEL-LIKE PROTEIN 1 (TMC1)

<130> 131522-01020

<140>
<141>

<150> 63/025,313
<151> 2020-05-15

<160> 76    

<170> PatentIn version 3.5

<210> 1
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 1
ggugaauagu auaacaauau                                                   20


<210> 2
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 2
auguuguuau aguauccacc                                                   20


<210> 3
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 3
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210> 4
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 4
ggugaagagg agaacaauau                                                   20


<210> 5
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 5
auguuguucu cgucuccacc                                                   20


<210> 6
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 6
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210> 7
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 7
ggugucgaga agaggagaac aauau                                             25


<210> 8
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 8
auguuguucu cgucuccucg acacc                                             25


<210> 9
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 9
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210> 10
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 10
ggguggaaua guauaacaau au                                                22


<210> 11
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
auguuguuau aguaucccac cu                                                22


<210> 12
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 13
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
guggaauagu auaacaauau                                                   20


<210> 14
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
auguuguuau aguaucccac                                                   20


<210> 15
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210> 16
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 16
ggugucgaga auaguauaac aauau                                             25


<210> 17
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
auguuguuau aguauccucg acacc                                             25


<210> 18
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210> 19
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
ggguggaaua guauaacaau au                                                22


<210> 20
<211> 22
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 20
auguuguuau aguaucccac cu                                                22


<210> 21
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 22
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
ggguggaaua guauacca                                                     18


<210> 23
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
ugguauagua ucccaccu                                                     18


<210> 24
<211> 40
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210> 25
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
guggguggaa uaguauacca                                                   20


<210> 26
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
ugguauagua ucccaccuac                                                   20


<210> 27
<211> 44
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210> 28
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 28
uggguggaau aguauacca                                                    19


<210> 29
<211> 19
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
ugguauagua ucccaccua                                                    19


<210> 30
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210> 31
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
gguggaauag uauacca                                                      17


<210> 32
<211> 17
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
ugguauagua ucccacc                                                      17


<210> 33
<211> 38
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210> 34
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
guggaauagu auacca                                                       16


<210> 35
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
ugguauagua ucccac                                                       16


<210> 36
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210> 37
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
ggugaauagu auaacaauau gcuaaauguu guuauaguau ccacc                       45


<210> 38
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 38
ggugaagagg agaacaauau gcuaaauguu guucucgucu ccacc                       45


<210> 39
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 39
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacc            55


<210> 40
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (5)..(6)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (23)..(23)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (25)..(25)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (27)..(28)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (32)..(32)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (34)..(35)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (37)..(41)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (43)..(49)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (52)..(52)
<223> 2'-O-methyl nucleotide

<220>
<221> modified_base
<222> (54)..(55)
<223> 2'-O-methyl nucleotide

<400> 40
nnngnngaga agaggagaan aanangnnaa angnngnnnn ngnnnnnnng anann            55


<210> 41
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 41
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 42
<211> 45
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 42
guggaauagu auaacaauau gcuaaauguu guuauaguau cccac                       45


<210> 43
<211> 55
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 43
ggugucgaga auaguauaac aauaugcuaa auguuguuau aguauccucg acacc            55


<210> 44
<211> 49
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 44
ggguggaaua guauaacaau augcuaaaug uuguuauagu aucccaccu                   49


<210> 45
<211> 40
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 45
ggguggaaua guauaccauu cgugguauag uaucccaccu                             40


<210> 46
<211> 44
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 46
guggguggaa uaguauacca uucgugguau aguaucccac cuac                        44


<210> 47
<211> 42
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 47
uggguggaau aguauaccau ucgugguaua guaucccacc ua                          42


<210> 48
<211> 38
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 48
gguggaauag uauaccauuc gugguauagu aucccacc                               38


<210> 49
<211> 36
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 49
guggaauagu auaccauucg ugguauagua ucccac                                 36


<210> 50
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 50
acatgaggat cacccatgt                                                    19


<210> 51
<211> 16
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      RFGF peptide sequence"

<400> 51
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210> 52
<211> 11
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      RFGF analogue peptide sequence"

<400> 52
Ala Ala Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10      


<210> 53
<211> 13
<212> PRT
<213> Human immunodeficiency virus

<400> 53
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210> 54
<211> 16
<212> PRT
<213> Drosophila sp.

<400> 54
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 55
<211> 2136
<212> DNA
<213> Homo sapiens

<400> 55
atggaacaaa aacttatttc tgaagaagat ctggatatag aagatgaaga aaacatgagt       60

tccagcagca ctgatgtgaa ggaaaaccgc aatctggaca acgtgtcccc caaggatggc      120

agcacacctg ggcctggcga gggctctcag ctctccaatg ggggtggtgg tggccccggc      180

agaaagcggc ccctggagga gggcagcaat ggccactcca agtaccgcct gaagaaaagg      240

aggaaaacac cagggcccgt cctccccaag aacgccctga tgcagctgaa tgagatcaag      300

cctggtttgc agtacacact cctgtcccag actgggcccg tgcacgcgcc tttgtttgtc      360

atgtctgtgg aggtgaatgg ccaggttttt gagggctctg gtcccacaaa gaaaaaggca      420

aaactccatg ctgctgagaa ggccttgagg tctttcgttc agtttcctaa tgcctctgag      480

gcccacctgg ccatggggag gaccctgtct gtcaacacgg acttcacatc tgaccaggcc      540

gacttccctg acacgctctt caatggtttt gaaactcctg acaaggcgga gcctcccttt      600

tacgtgggct ccaatgggga tgactccttc agttccagcg gggacctcag cttgtctgct      660

tccccggtgc ctgccagcct agcccagcct cctctccctg tcttaccacc attcccaccc      720

ccgagtggga agaatcccgt gatgatcttg aacgaactgc gcccaggact caagtatgac      780

ttcctctccg agagcgggga gagccatgcc aagagcttcg tcatgtctgt ggtcgtggat      840

ggtcagttct ttgaaggctc ggggagaaac aagaagcttg ccaaggcccg ggctgcgcag      900

tctgccctgg ccgccatttt taacttgcac ttggatcaga cgccatctcg ccagcctatt      960

cccagtgagg gtcttcagct gcatttaccg caggttttag ctgacgctgt ctcacgcctg     1020

gtcctgggta agtttggtga cctgaccgac aacttctcct cccctcacgc tcgcagaaaa     1080

gtgctggctg gagtcgtcat gacaacaggc acagatgtta aagatgccaa ggtgataagt     1140

gtttctacag gaacaaaatg tattaatggt gaatacatga gtgatcgtgg ccttgcatta     1200

aatgactgcc atgcagaaat aatatctcgg agatccttgc tcagatttct ttatacacaa     1260

cttgagcttt acttaaataa caaagatgat caaaaaagat ccatctttca gaaatcagag     1320

cgaggggggt ttaggctgaa ggagaatgtc cagtttcatc tgtacatcag cacctctccc     1380

tgtggagatg ccagaatctt ctcaccacat gagccaatcc tggaagaacc agcagataga     1440

cacccaaatc gtaaagcaag aggacagcta cggaccaaaa tagagtctgg tgaggggacg     1500

attccagtgc gctccaatgc gagcatccaa acgtgggacg gggtgctgca aggggagcgg     1560

ctgctcacca tgtcctgcag tgacaagatt gcacgctgga acgtggtggg catccaggga     1620

tccctgctca gcattttcgt ggagcccatt tacttctcga gcatcatcct gggcagcctt     1680

taccacgggg accacctttc cagggccatg taccagcgga tctccaacat agaggacctg     1740

ccacctctct acaccctcaa caagcctttg ctcagtggca tcagcaatgc agaagcacgg     1800

cagccaggga aggcccccaa cttcagtgtc aactggacgg taggcgactc cgctattgag     1860

gtcatcaacg ccacgactgg gaaggatgag ctgggccgcg cgtcccgcct gtgtaagcac     1920

gcgttgtact gtcgctggat gcgtgtgcac ggcaaggttc cctcccactt actacgctcc     1980

aagattacca agcccaacgt gtaccatgag tccaagctgg cggcaaagga gtaccaggcc     2040

gccaaggcgc gtctgttcac agccttcatc aaggcggggc tgggggcctg ggtggagaag     2100

cccaccgagc aggaccagtt ctcactcacg ccctga                               2136


<210> 56
<211> 3711
<212> DNA
<213> Homo sapiens

<400> 56
atggaacaaa aacttatttc tgaagaagat ctgaatccgc ggcaggggta ttccctcagc       60

ggatactaca cccatccatt tcaaggctat gagcacagac agctcaggta ccagcagcct      120

gggccaggat cttcccccag tagtttcctg cttaagcaaa tagaatttct caaggggcag      180

ctcccagaag caccggtgat tggaaagcag acaccgtcac tgccaccttc cctcccagga      240

ctccggccaa ggtttccagt actacttgcc tccagtacca gaggcaggca agtggacatc      300

aggggtgtcc ccaggggcgt gcatctcaga agtcaggggc tccagagagg gttccagcat      360

ccttcaccac gtggcaggag tctgccacag agaggtgttg attgcctttc ctcacatttc      420

caggaactga gtatctacca agatcaggaa caaaggatct taaagttcct ggaagagctt      480

ggggaaggga aggccaccac agcacatgat ctgtctggga aacttgggac tccgaagaaa      540

gaaatcaatc gagttttata ctccctggca aagaagggca agctacagaa agaggcagga      600

acaccccctt tgtggaaaat cgcggtctcc actcaggctt ggaaccagca cagcggagtg      660

gtaagaccag acggtcatag ccaaggagcc ccaaactcag acccgagttt ggaaccggaa      720

gacagaaact ccacatctgt ctcagaagat cttcttgagc cttttattgc agtctcagct      780

caggcttgga accagcacag cggagtggta agaccagaca gtcatagcca aggatcccca      840

aactcagacc caggtttgga acctgaagac agcaactcca catctgcctt ggaagatcct      900

cttgagtttt tagacatggc cgagatcaag gagaaaatct gcgactatct cttcaatgtg      960

tctgactcct ctgccctgaa tttggctaaa aatattggcc ttaccaaggc ccgagatata     1020

aatgctgtgc taattgacat ggaaaggcag ggggatgtct atagacaagg gacaacccct     1080

cccatatggc atttgacaga caagaagcga gagaggatgc aaatcaagag aaatacgaac     1140

agtgttcctg aaaccgctcc agctgcaatc cctgagacca aaagaaacgc agagttcctc     1200

acctgtaata tacccacatc aaatgcctca aataacatgg taaccacaga aaaagtggag     1260

aatgggcagg aacctgtcat aaagttagaa aacaggcaag aggccagacc agaaccagca     1320

agactgaaac cacctgttca ttacaatggc ccctcaaaag cagggtatgt tgactttgaa     1380

aatggccagt gggccacaga tgacatccca gatgacttga atagtatccg cgcagcacca     1440

ggtgagtttc gagccatcat ggagatgccc tccttctaca gtcatggctt gccacggtgt     1500

tcaccctaca agaaactgac agagtgccag ctgaagaacc ccatcagcgg gctgttagaa     1560

tatgcccagt tcgctagtca aacctgtgag ttcaacatga tagagcagag tggaccaccc     1620

catgaacctc gatttaaatt ccaggttgtc atcaatggcc gagagtttcc cccagctgaa     1680

gctggaagca agaaagtggc caagcaggat gcagctatga aagccatgac aattctgcta     1740

gaggaagcca aagccaagga cagtggaaaa tcagaagaat catcccacta ttccacagag     1800

aaagaatcag agaagactgc agagtcccag acccccaccc cttcagccac atccttcttt     1860

tctgggaaga gccccgtcac cacactgctt gagtgtatgc acaaattggg gaactcctgc     1920

gaattccgtc tcctgtccaa agaaggccct gcccatgaac ccaagttcca atactgtgtt     1980

gcagtgggag cccaaacttt ccccagtgtg agtgctccca gcaagaaagt ggcaaagcag     2040

atggccgcag aggaagccat gaaggccctg catggggagg cgaccaactc catggcttct     2100

gataaccagc ctgaaggtat gatctcagag tcacttgata acttggaatc catgatgccc     2160

aacaaggtca ggaagattgg cgagctcgtg agatacctga acaccaaccc tgtgggtggc     2220

cttttggagt acgcccgctc ccatggcttt gctgctgaat tcaagttggt cgaccagtcc     2280

ggacctcctc acgagcccaa gttcgtttac caagcaaaag ttgggggtcg ctggttccca     2340

gccgtctgcg cacacagcaa gaagcaaggc aagcaggaag cagcagatgc ggctctccgt     2400

gtcttgattg gggagaacga gaaggcagaa cgcatgggtt tcacagaggt aaccccagtg     2460

acaggggcca gtctcagaag aactatgctc ctcctctcaa ggtccccaga agcacagcca     2520

aagacactcc ctctcactgg cagcaccttc catgaccaga tagccatgct gagccaccgg     2580

tgcttcaaca ctctgactaa cagcttccag ccctccttgc tcggccgcaa gattctggcc     2640

gccatcatta tgaaaaaaga ctctgaggac atgggtgtcg tcgtcagctt gggaacaggg     2700

aatcgctgtg tgaaaggaga ttctctcagc ctaaaaggag aaactgtcaa tgactgccat     2760

gcagaaataa tctcccggag aggcttcatc aggtttctct acagtgagtt aatgaaatac     2820

aactcccaga ctgcgaagga tagtatattt gaacctgcta agggaggaga aaagctccaa     2880

ataaaaaaga ctgtgtcatt ccatctgtat atcagcactg ctccgtgtgg agatggcgcc     2940

ctctttgaca agtcctgcag cgaccgtgct atggaaagca cagaatcccg ccactaccct     3000

gtcttcgaga atcccaaaca aggaaagctc cgcaccaagg tggagaacgg agaaggcaca     3060

atccctgtgg aatccagtga cattgtgcct acgtgggatg gcattcggct cggggagaga     3120

ctccgtacca tgtcctgtag tgacaaaatc ctacgctgga acgtgctggg cctgcaaggg     3180

gcactgttga cccacttcct gcagcccatt tatctcaaat ctgtcacatt gggttacctt     3240

ttcagccaag ggcatctgac ccgtgctatt tgctgtcgtg tgacaagaga tgggagtgca     3300

tttgaggatg gactacgaca tccctttatt gtcaaccacc ccaaggttgg cagagtcagc     3360

atatatgatt ccaaaaggca atccgggaag actaaggaga caagcgtcaa ctggtgtctg     3420

gctgatggct atgacctgga gatcctggac ggtaccagag gcactgtgga tgggccacgg     3480

aatgaattgt cccgggtctc caaaaagaac atttttcttc tatttaagaa gctctgctcc     3540

ttccgttacc gcagggatct actgagactc tcctatggtg aggccaagaa agctgcccgt     3600

gactacgaga cggccaagaa ctacttcaaa aaaggcctga aggatatggg ctatgggaac     3660

tggattagca aaccccagga ggaaaagaac ttttatctct gcccagtata g              3711


<210> 57
<211> 5340
<212> DNA
<213> Homo sapiens

<400> 57
gatggcgcgc gactgtttcc catctactca gaggctgagg cgggagaatc gcttgaaccc       60

ggaaggcgga ggttgcagtg agctgaaatc acgccattgc gctccagcct gggtgacaga      120

gcaagactcc gtcacaaaaa aaaaaagaaa aaagaaacac cagttttctg atttcaccga      180

agacctactg cctcagaaac tatgagggca gaacccagca atctgtgctt tctttcacaa      240

gccctccagg agttgctgaa atttaggaat cattgcccca aaaagtggcc ctcataatga      300

tgccagatgg gatcttactc tgttgcccag gctggagtgc agtggtgcga tctcggctct      360

ctgcaacctc cgcctcccag gttcaagtga ttctcctgcc tcggcctcct gagtagctgg      420

gatttcaggc catgaaagat cactgtttta gtctgcgtgg tgcagtggaa cagatagacc      480

tcggtttgaa tctcagctct actgtttact agacatgaaa tggggaaatc taaaatgaga      540

tgccagaagc ctcaaaaatg gaaaaccccc tgtgcttcac atctgaaaat ctctgctggg      600

ggcagcaact ttgagcctgt ggggaaggaa ctgtccacgt ggagtggtct ggtgaatgct      660

taaggagctg cagaagggaa gtccctctcc aaactagcca gccactgaga ccttctgaca      720

ggacaccccc aggatgtcac ccaaaaaagt acaaatcaaa gtggaggaaa aagaagacga      780

gactgaggaa agctcaagtg aagaggaaga ggaggtggaa gataagctac ctcgaagaga      840

gagcttgaga ccaaagagga aacggaccag agatgttatc aatgaggatg acccagaacc      900

tgaaccagag gatgaagaaa caaggaaggc aagagaaaaa gagaggagga ggaggctaaa      960

gagaggagca gaagaagaag aaattgatga agaggaattg gaaagattga aggcagagtt     1020

agatgagaaa agacaaataa ttgctactgt caaatgcaaa ccatggaaga tggagaagaa     1080

aattgaagtt ctcaaggagg caaaaaaatt tgtgagtgaa aatgaagggg ctcttgggaa     1140

aggaaaagga aaacggtggt ttgcatttaa gatgatgatg gccaagaaat gggcaaaatt     1200

cctccgtgat tttgagaact tcaaagctgc gtgtgtccca tgggaaaata aaatcaaggc     1260

tattgaaagt cagtttggct cctcagtggc ctcatacttc ctcttcttga gatggatgta     1320

tggagtcaat atggttctct ttatcctgac atttagcctc atcatgttgc cagagtacct     1380

ctggggtttg ccatatggca gtttacctag gaaaaccgtt cccagagccg aagaggcatc     1440

ggcagcaaac tttggtgtgt tgtacgactt caatggtttg gcacaatatt ccgttctctt     1500

ttatggctat tatgacaata aacgaacaat tggatggatg aatttcaggt tgccgctctc     1560

ctattttcta gtggggatta tgtgcattgg atacagcttt ctggttgtcc tcaaagcaat     1620

gaccaaaaac attggtgatg atggaggtgg agatgacaac actttcaatt tcagctggaa     1680

ggtctttacc agctgggact acctgatcgg caatcctgaa acagcagaca acaaatttaa     1740

ttctatcaca atgaacttta aggaagctat cacagaagaa aaagcagccc aagtagaaga     1800

aaacgtccac ttgatcagat tcctgaggtt tctggctaac ttcttcgtgt ttctaacact     1860

tggagggagt ggatacctca tcttttgggc tgtgaagcga tcccaggaat ttgcacagca     1920

agatcctgac acccttgggt ggtgggaaaa aaatgaaatg aacatggtta tgtccctcct     1980

agggatgttc tgtccaacat tgtttgactt atttgctgaa ttagaagact accatcctct     2040

catcgctttg aaatggctac tgggacgcat ttttgctctt cttttaggca atttatacgt     2100

atttattctt gcattaatgg atgagattaa caacaagatt gaagaggaga agctagtaaa     2160

ggccaatatt accctttggg aagccaatat gatcaaggcc tacaatgcat cattctctga     2220

aaatagcact ggaccaccct tttttgttca ccctgcagat gtacctcgag gaccttgctg     2280

ggaaacaatg gtgggacagg agtttgtgag gctgacagtc tctgatgttc tgaccaccta     2340

cgtcacaatc ctcattgggg actttctaag ggcatgtttt gtgaggtttt gcaattattg     2400

ctggtgctgg gacttggagt atggatatcc ttcatacacc gaattcgaca tcagtggcaa     2460

cgtcctcgct ctgatcttca accaaggcat gatctggatg ggctccttct ttgctcccag     2520

cctcccaggc atcaatatcc ttcgactcca tacatccatg tacttccagt gctgggccgt     2580

tatgtgctgc aatgttcctg aggccagggt cttcaaagct tccagatcaa ataacttcta     2640

cctgggcatg ctactgctca tcctcttcct gtccacaatg cctgtcttgt acatgatcgt     2700

gtccctccca ccatcttttg attgtggtcc attcagtggc aaaaatagaa tgtttgaagt     2760

cattggagag accctggagc acgatttccc aagctggatg gcgaagatct tgagacagct     2820

ttcaaaccct gggctggtca ttgctgtcat tttggtgatg gttttggcca tctattatct     2880

caatgctact gccaagggcc agaaggcagc gaatctggat ctcaaaaaga agatgaaaat     2940

gcaagctttg gagaacaaaa tgcgaaacaa gaaaatggca gctgcacgag cagctgcagc     3000

tgctggtcgc cagtaataag tatcctgaga gcccagaaaa ggtacacttt gccttgctgt     3060

ttaaaagtaa tgcaatatgt gaacgcccag agaacaagca ctgtggaact gctattttcc     3120

tgttctaccc ttgatggatt ttcaaggtca tgctggccaa ttaaggcatc atcagtccta     3180

cctgagcaac aagaatctaa actttattcc aagtcagaaa ctgtttctgc agagccactc     3240

tctcccctgc tccatttcgt gacttttttt ttttttttaa caaattgagt ttagaagtga     3300

gtgtaatcca gcaatacagt ttactggttt agttggtggg ttaattaaaa aaaatttgct     3360

catatgaact ttcattttat atgtttcttt tgcctgagtt tccttaaact gagagcagaa     3420

atatttcacc ctttttcctc taagttcaga aatatttgca aaaagtactc attgtaatca     3480

ttcattaact cactttttga aaccaatacc ttattttctc tttttttcta cctgtctccc     3540

caaccacgcg ccccacaaat atattcctaa aacctttgta tttggtgctg gattcagtat     3600

gaaaagaaat agggttttta gaagaaaaaa aaatcctata tgaattgggg cctggatagc     3660

actgagttga agatcttgaa gatctcttac tttgagaagg tacatgagtc ttacacaacc     3720

tagcttttta tgagataaaa ttaaaaaaaa aaggaaagac atcataaatg actgttgttc     3780

tctcacagtc tgctcatttg tcttccaatg atcatgttat cagtggtgaa tccatacagg     3840

tctgcatcaa actcgataca attcttgcct ccttggaggg aagaattcag ctgaggggca     3900

gaagtaggtt tatggcagag ggagagaatg aggcaagttt tagagcagga gtgtaggttt     3960

attaaaaagt tttacagcag gaacaaaagg aaataaaata tacttggaag agagccaagt     4020

gggcaaattg agagttccaa gtgccctgtt cagctttgac ctgggtttct atacactggc     4080

atggttctgg agtttgcatc tctccccgct tgattttttt ggcggatggg ctgtccgtgt     4140

ggatggtggc ctgccggcag ttggaaggag ctatgtgtac aatgtgttac tgaagttgtg     4200

tgcctgctca cttgtgacgt tttcccttac catccagcgt tcctggagga aggtcatata     4260

ctagttaaac tctgccattt tgcttagtgg gcatgcttga gcccacttgc ccaactccta     4320

agatctccgg ctcaggtgtt ttctatctat tgggagactg tctttcccta gcactggttg     4380

ccactaatta ttattttaga gagatagttt aaccaccacc tgaccatcac caaatggtca     4440

cctgacattc ctgtgggatg ggtggtgggg ggcctctctt gccctgctta tgtttttatg     4500

tttgcctaac tacctactct aacaatcata tcctgtaagc ttggattcta atgttctata     4560

atttttttct ttgctttttt tgttaaggtc aggaaaacac acttctgttg ggggccttaa     4620

tttatagata tgtttaagca ttattatgga tttacagttt gaattgactt taagtagtaa     4680

cactcagtgc cctcactagc cttgttgtgc gactttaatt gcatagctta actcagtgtg     4740

cctttccaaa actaagccaa tttgcttgcc attccctgca gttgacttac tgatttctat     4800

tatcctgtct ctgagtttct cattcttttt gatcaccaaa aggcagccat agaataatcg     4860

cactgtttcc ctgccagttc taaactttat tcctctggtt gtctttttca gattgacttc     4920

cattctcaat cttatcactc cctttttagg attccttggg ctcttatgtc tgtaattcag     4980

agtctattat ttatattgat tttcatgtga cttgtaatgg ttccttatta ttttttgatg     5040

catggattat ctttcttgtc cttattgtaa attctctgtg agcaggggtt gtatcttcta     5100

actcttttgt atgcctagta tagtgctgtg cacaagtagg cgctgaataa atgcttgcta     5160

attaaattga atcaatttaa cttacagcaa ttgtgttatg agacaaaaac ttctgttacc     5220

tgcatgaaaa cattttacta tgatgtaaga aatggattat ctgttgatag gctgagttta     5280

ttgtttaatt agattataat gcagatgagt aaataaagct agtgtttatt tctacttgga     5340


<210> 58
<211> 2310
<212> DNA
<213> Homo sapiens

<400> 58
atgtcaccca aaaaagtaca aatcaaagtg gaggaaaaag aagacgagac tgaggaaagc       60

tcaagtgaag aggaagagga ggtggaagat aagctacctc gaagagagag cttgagacca      120

aagaggaaac ggaccagaga tgttatcaat gaggatgacc cagaacctga accagaggat      180

gaagaaacaa ggaaggcaag agaaaaagag aggaggagga ggctaaagag aggagcagaa      240

gaagaagaaa ttgatgaaga ggaattggaa agattgaagg cagagttaga tgagaaaaga      300

caaataattg ctactgtcaa atgcaaacca tggaagatgg agaagaaaat tgaagttctc      360

aaggaggcaa aaaaatttgt gagtgaaaat gaaggggctc ttgggaaagg aaaaggaaaa      420

cggtggtttg catttaagat gatgatggcc aagaaatggg caaaattcct ccgtgatttt      480

gagaacttca aagctgcgtg tgtcccatgg gaaaataaaa tcaaggctat tgaaagtcag      540

tttggctcct cagtggcctc atacttcctc ttcttgagat ggatgtatgg agtcaatatg      600

gttctcttta tcctgacatt tagcctcatc atgttgccag agtacctctg gggtttgcca      660

tatggcagtt tacctaggaa aaccgttccc agagccgaag aggcatcggc agcaaacttt      720

ggtgtgttgt acgacttcaa tggtttggca caatattccg ttctctttta tggctattat      780

gacaataaac gaacaattgg atggatgaat ttcaggttgc cgctctccta ttttctagtg      840

gggattatgt gcattggata cagctttctg gttgtcctca aagcaatgac caaaaacatt      900

ggtgatgatg gaggtggaga tgacaacact ttcaatttca gctggaaggt ctttaccagc      960

tgggactacc tgatcggcaa tcctgaaaca gcagacaaca aatttaattc tatcacaatg     1020

aactttaagg aagctatcac agaagaaaaa gcagcccaag tagaagaaaa cgtccacttg     1080

atcagattcc tgaggtttct ggctaacttc ttcgtgtttc taacacttgg agggagtgga     1140

tacctcatct tttgggctgt gaagcgatcc caggaatttg cacagcaaga tcctgacacc     1200

cttgggtggt gggaaaaaaa tgaaatgaac atggttatgt ccctcctagg gatgttctgt     1260

ccaacattgt ttgacttatt tgctgaatta gaagactacc atcctctcat cgctttgaaa     1320

tggctactgg gacgcatttt tgctcttctt ttaggcaatt tatacgtatt tattcttgca     1380

ttaatggatg agattaacaa caagattgaa gaggagaagc tagtaaaggc caatattacc     1440

ctttgggaag ccaatatgat caaggcctac aatgcatcat tctctgaaaa tagcactgga     1500

ccaccctttt ttgttcaccc tgcagatgta cctcgaggac cttgctggga aacaatggtg     1560

ggacaggagt ttgtgaggct gacagtctct gatgttctga ccacctacgt cacaatcctc     1620

attggggact ttctaagggc atgttttgtg aggttttgca attattgctg gtgctgggac     1680

ttggagtatg gatatccttc atacaccgaa ttcaacatca gtggcaacgt cctcgctctg     1740

atcttcaacc aaggcatgat ctggatgggc tccttctttg ctcccagcct cccaggcatc     1800

aatatccttc gactccatac atccatgtac ttccagtgct gggccgttat gtgctgcaat     1860

gttcctgagg ccagggtctt caaagcttcc agatcaaata acttctacct gggcatgcta     1920

ctgctcatcc tcttcctgtc cacaatgcct gtcttgtaca tgatcgtgtc cctcccacca     1980

tcttttgatt gtggtccatt cagtggcaaa aatagaatgt ttgaagtcat tggagagacc     2040

ctggagcacg atttcccaag ctggatggcg aagatcttga gacagctttc aaaccctggg     2100

ctggtcattg ctgtcatttt ggtgatggtt ttggccatct attatctcaa tgctactgcc     2160

aagggccaga aggcagcgaa tctggatctc aaaaagaaga tgaaaatgca agctttggag     2220

aacaaaatgc gaaacaagaa aatggcagct gcacgagcag ctgcagctgc tggtcgccag     2280

tacccatacg acgtcccaga ctacgcttaa                                      2310


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 59
gacagtctct gatgttctga                                                   20


<210> 60
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 60
catggatgta tggagtcgaa g                                                 21


<210> 61
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 61
gguugaagau cagagcgagg acguugccac ugaugtcgaa uucgguguau                  50


<210> 62
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 62
gguugaagau cagagcgagg ccguggccac ugaugtcgaa uucgguguau                  50


<210> 63
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 63
gguugaagau cagagggaga acguugccac ugaugtcgaa uucgguguau                  50


<210> 64
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 64
gguugaagau cagagcgagg acguugccac ugaugtcgaa uucgguguau                  50


<210> 65
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 65
gguugaagau cagagcgagg ccguggccac ugaugtcgaa uucgguguau                  50


<210> 66
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 66
gguugaagau cagagggaga acguugccac ugaugtcgaa uucgguguau                  50


<210> 67
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 67
gguugaagau cagagcgagg acguugccac ugaugtcgaa uucgguguau                  50


<210> 68
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 68
gguugaagau cagagcgagg acguugccac ugaugtcgaa uucgguguau                  50


<210> 69
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 69
gguugaagau cagagcgagg acguugccac ugaugucgaa uucgguguau                  50


<210> 70
<211> 50
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 70
gguugaagau cagagcgagg acguugccac ugaugucgaa uucgguguau                  50


<210> 71
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 71
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacccugau       60

gtcgaauucg gug                                                          73


<210> 72
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 72
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacccugau       60

gtcgaauucg gug                                                          73


<210> 73
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 73
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acacccugau       60

gtcgaauucg gug                                                          73


<210> 74
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 74
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgauca       60

gagcgaggac guugccactg augtcgaauu cggtg                                  95


<210> 75
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 75
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgauca       60

gagcgaggac guugccactg augtcgaauu cggtg                                  95


<210> 76
<211> 95
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<220>
<221> source
<223> /note="Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide"

<400> 76
ggugucgaga agaggagaac aauaugcuaa auguuguucu cgucuccucg acaccgauca       60

gagcgaggac guugccactg augucgaauu cggtg                                  95


