                         SEQUENCE LISTING

<110>  The Trustees of The University of Pennsylvania
 
<120>  COMPOSITIONS FOR DRG-SPECIFIC REDUCTION OF TRANSGENE EXPRESSION

<130>  21-9594PCT

<150>  63/023,593
<151>  2020-05-12

<150>  63/043562
<151>  2020-06-24

<150>  63/079299
<151>  2020-09-16

<150>  63/152042
<151>  2021-02-22

<150>  63/038488
<151>  2020-06-12

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  miR-183 target

<400>  1
agtgaattct accagtgcca ta                                                22


<210>  2
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  mirR-96 target

<400>  2
agcaaaaatg tgctagtgcc aaa                                               23


<210>  3
<211>  24
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miR-182 target

<400>  3
agtgtgagtt ctaccattgc caaa                                              24


<210>  4
<211>  23
<212>  DNA
<213>  Artificial sequence

<220>
<223>  miR-145 target

<400>  4
agggattcct gggaaaactg gac                                               23


<210>  5
<211>  4
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Spacer (i)

<400>  5
ggat                                                                     4


<210>  6
<211>  6
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Spacer (ii)

<400>  6
cacgtg                                                                   6


<210>  7
<211>  6
<212>  DNA
<213>  Artificial sequence

<220>
<223>  spacer iii

<400>  7
gcatgc                                                                   6


<210>  8
<211>  2211
<212>  DNA
<213>  adeno-associated virus hu68


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  8
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc agt         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa ggc att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cgg ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gaa gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gtg ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc ccc gac cct caa cca atc gga gaa cct ccc        576
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc        624
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc        672
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac        816
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga        864
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg caa aga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att        960
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gct aat       1008
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       1056
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       1104
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat cta acg ctt aat gat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc caa gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       1200
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tat gct cac agc caa agc ctg       1296
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga ctc atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       1392
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       1440
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       1488
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       1536
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       1584
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       1632
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       1680
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act acc aac cca gta gca acg gag tcc       1728
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       1776
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       1824
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       1920
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gct ttc aac aag gac aag ctg aac tct ttc atc acc       2016
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag att gag tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gtt       2160
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat tct gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       2208
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               

taa                                                                   2211


<210>  9
<211>  736
<212>  PRT
<213>  adeno-associated virus hu68

<400>  9

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Val Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  10
<211>  3198
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.eGFP.miR145.rBG.ITR


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' - AAV2 - ITR

<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' - AAV2 - ITR

<220>
<221>  promoter
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (1979)..(2698)
<223>  eGFP gene

<220>
<221>  misc_feature
<222>  (2705)..(2727)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2728)..(2731)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2732)..(2754)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2755)..(2760)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2761)..(2783)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2784)..(2789)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2790)..(2812)
<223>  miR145

<220>
<221>  misc_feature
<222>  (2981)..(3198)
<223>  3' ITR

<400>  10
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagggat tcctgggaaa actggacgga tagggattcc tgggaaaact ggaccacgtg     2760

agggattcct gggaaaactg gacgcatgca gggattcctg ggaaaactgg acgcggccgc     2820

ctcgaggacg gggtgaacta cgcctgagga tccgatcttt ttccctctgc caaaaattat     2880

ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc     2940

attgcaatag tgtgttggaa ttttttgtgt ctctcactcg gaagcaattc gttgatctga     3000

atttcgacca cccataatac ccattaccct ggtagataag tagcatggcg ggttaatcat     3060

taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3120

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     3180

gagcgagcga gcgcgcag                                                   3198


<210>  11
<211>  3202
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.eGFP.miR182.rGB.ITR


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' ITR (AAV2)

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  misc_feature
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (958)..(1930)
<223>  chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1979)..(2698)
<223>  eGFP coding sequence

<220>
<221>  misc_feature
<222>  (2705)..(2728)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2729)..(2732)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2733)..(2756)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2757)..(2760)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2763)..(2786)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2787)..(2792)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2793)..(2816)
<223>  miR182

<220>
<221>  polyA_signal
<222>  (2858)..(2984)

<220>
<221>  misc_feature
<222>  (3073)..(3202)
<223>  3' ITR

<400>  11
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagtgtg agttctacca ttgccaaagg atagtgtgag ttctaccatt gccaaacacg     2760

tgagtgtgag ttctaccatt gccaaagcat gcagtgtgag ttctaccatt gccaaagcgg     2820

ccgcctcgag gacggggtga actacgcctg aggatccgat ctttttccct ctgccaaaaa     2880

ttatggggac atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat     2940

tttcattgca atagtgtgtt ggaatttttt gtgtctctca ctcggaagca attcgttgat     3000

ctgaatttcg accacccata atacccatta ccctggtaga taagtagcat ggcgggttaa     3060

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3120

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3180

cagtgagcga gcgagcgcgc ag                                              3202


<210>  12
<211>  3198
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.eGFP.miRNA96.rBG.ITR


<220>
<221>  misc_feature
<222>  (1979)..(2699)
<223>  eGFP coding sequence

<220>
<221>  misc_feature
<222>  (2705)..(2727)
<223>  miR96

<220>
<221>  misc_feature
<222>  (2728)..(2731)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2732)..(2754)
<223>  miR96

<220>
<221>  misc_feature
<222>  (2755)..(2760)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2761)..(2783)
<223>  miR96

<220>
<221>  misc_feature
<222>  (2784)..(2789)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2790)..(2812)
<223>  miR96

<400>  12
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagcaaa aatgtgctag tgccaaagga tagcaaaaat gtgctagtgc caaacacgtg     2760

agcaaaaatg tgctagtgcc aaagcatgca gcaaaaatgt gctagtgcca aagcggccgc     2820

ctcgaggacg gggtgaacta cgcctgagga tccgatcttt ttccctctgc caaaaattat     2880

ggggacatca tgaagcccct tgagcatctg acttctggct aataaaggaa atttattttc     2940

attgcaatag tgtgttggaa ttttttgtgt ctctcactcg gaagcaattc gttgatctga     3000

atttcgacca cccataatac ccattaccct ggtagataag tagcatggcg ggttaatcat     3060

taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     3120

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     3180

gagcgagcga gcgcgcag                                                   3198


<210>  13
<211>  3194
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.eGFP.miRNA183.rBG.ITR


<220>
<221>  misc_feature
<222>  (1979)..(2698)
<223>  eGFP coding sequence

<220>
<221>  misc_feature
<222>  (2705)..(2726)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2727)..(2730)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2731)..(2752)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2753)..(2758)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2781)..(2786)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2787)..(2808)
<223>  miRNA183

<400>  13
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagtgaa ttctaccagt gccataggat agtgaattct accagtgcca tacacgtgag     2760

tgaattctac cagtgccata gcatgcagtg aattctacca gtgccatagc ggccgcctcg     2820

aggacggggt gaactacgcc tgaggatccg atctttttcc ctctgccaaa aattatgggg     2880

acatcatgaa gccccttgag catctgactt ctggctaata aaggaaattt attttcattg     2940

caatagtgtg ttggaatttt ttgtgtctct cactcggaag caattcgttg atctgaattt     3000

cgaccaccca taatacccat taccctggta gataagtagc atggcgggtt aatcattaac     3060

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     3120

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     3180

gagcgagcgc gcag                                                       3194


<210>  14
<211>  4300
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.hIDUAcoV1.rBG.ITR


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  misc_feature
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (836)..(839)
<223>  TATA

<220>
<221>  misc_feature
<222>  (958)..(1930)
<223>  chicken beta-actin intron

<400>  14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattcagcca ccatgaggcc tctcagacct agagctgctc tgctggcact     1980

gctggcttct ctgcttgctg ctcctcctgt ggctcctgcc gaagctcctc atctggtgca     2040

cgtggatgcc gccagagcac tgtggcccct gagaagattt tggcggagca ccggcttttg     2100

ccctccactg cctcattctc aggccgacca gtacgtgctg agctgggacc agcaactgaa     2160

cctggcctac gtgggagccg tgcctcacag aggcattaag caagtgcgga cccactggct     2220

gctggaactg gtcacaacaa gaggcagcac aggcagaggc ctgagctaca acttcaccca     2280

cctggacggc tacctggacc tgctgagaga gaatcagctg ctgcctggct tcgagctgat     2340

gggctctgcc tctggccact tcaccgactt cgaggacaag cagcaggttt tcgagtggaa     2400

ggacctggtg tccagcctgg ccagacggta catcggcaga tacggactgg cccacgtgtc     2460

caagtggaac ttcgagacct ggaacgagcc cgaccaccac gacttcgaca acgtgtcaat     2520

gaccatgcag ggctttctga actactacga cgcctgcagc gagggcctga gagctgcttc     2580

tcctgctctg agacttggcg gccctggcga ctcttttcac acccctccaa gaagccctct     2640

gtcctgggga ctgctgagac actgtcacga cggcaccaat ttcttcaccg gcgaggctgg     2700

cgtgcggctg gattatatca gcctgcacag aaagggcgcc agaagcagca tcagcatcct     2760

ggaacaagag aaggtggtgg cccagcagat cagacagctg ttccccaagt tcgccgacac     2820

acccatctac aacgacgagg ccgatcctct cgttggctgg tcacttcctc agccttggag     2880

agccgatgtg acctatgccg ccatggtggt caaagtgatc gcccagcacc agaatctgct     2940

gctcgccaat accaccagcg cctttccata cgctctgctg agcaacgaca acgccttcct     3000

gagctatcac cctcatcctt tcgctcagcg gaccctgacc gccagattcc aagtgaacaa     3060

cacccggcct ccacacgtgc agctgctgag aaaaccagtg ctgacagcca tgggcctgct     3120

cgccctgctg gacgaagaac aactgtgggc cgaagtgtcc caggccggaa cagtgctgga     3180

tagcaatcac acagtgggcg tgctggcctc cgctcataga cctcaaggac cagccgatgc     3240

ttggagggct gccgtgctga tctacgccag cgacgataca agggctcacc ccaacagatc     3300

cgtggccgtg acactgagac tgagaggcgt tccaccagga cctggcctgg tgtacgtgac     3360

cagatacctg gacaacggcc tgtgcagccc tgatggcgaa tggcgtagac taggcagacc     3420

tgtgtttcct accgccgagc agttcagacg gatgagagcc gctgaagatc ccgtggctgc     3480

tgctccaaga cctcttccag ctggtggcag actgactctg aggcctgcac tcagactgcc     3540

tagtctgctg ctggtgcacg tctgtgccag acctgagaag cctcctggcc aagtgacaag     3600

actgagggcc ctgccactga cacagggaca gctggttctt gtttggagcg acgagcacgt     3660

gggcagcaag tgtctgtgga cctacgagat ccagttcagc caggacggca aggcctacac     3720

acccgtgtct agaaagccta gcaccttcaa cctgttcgtg ttcagccccg atacaggcgc     3780

cgtgtctggc agctatagag tcagagccct ggactactgg gccagaccag gaccattttc     3840

tgaccccgtg ccttacctgg aagtgcccgt tcctagaggc cctccttctc ctggaaatcc     3900

ctgataaggt accataccta ggctcgagga cggggtgaac tacgcctgag gatccgatct     3960

ttttccctct gccaaaaatt atggggacat catgaagccc cttgagcatc tgacttctgg     4020

ctaataaagg aaatttattt tcattgcaat agtgtgttgg aattttttgt gtctctcact     4080

cggaagcaat tcgttgatct gaatttcgac cacccataat acccattacc ctggtagata     4140

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     4200

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4260

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           4300


<210>  15
<211>  4403
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ITR.CB7.CI.hIDUAcoV1.miR183.ITR


<220>
<221>  misc_feature
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (198)..(579)
<223>  CMV IE promoter

<220>
<221>  misc_feature
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  misc_feature
<222>  (1938)..(3908)
<223>  hIDUAcoV1

<220>
<221>  misc_feature
<222>  (3915)..(3936)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (3937)..(3940)
<223>  spacer

<220>
<221>  misc_feature
<222>  (3941)..(3962)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (3963)..(3968)
<223>  spacer

<220>
<221>  misc_feature
<222>  (3969)..(3990)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (3991)..(3996)
<223>  spacer

<220>
<221>  misc_feature
<222>  (3997)..(4018)
<223>  miRNA183

<400>  15
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattcagcca ccatgaggcc tctcagacct agagctgctc tgctggcact     1980

gctggcttct ctgcttgctg ctcctcctgt ggctcctgcc gaagctcctc atctggtgca     2040

cgtggatgcc gccagagcac tgtggcccct gagaagattt tggcggagca ccggcttttg     2100

ccctccactg cctcattctc aggccgacca gtacgtgctg agctgggacc agcaactgaa     2160

cctggcctac gtgggagccg tgcctcacag aggcattaag caagtgcgga cccactggct     2220

gctggaactg gtcacaacaa gaggcagcac aggcagaggc ctgagctaca acttcaccca     2280

cctggacggc tacctggacc tgctgagaga gaatcagctg ctgcctggct tcgagctgat     2340

gggctctgcc tctggccact tcaccgactt cgaggacaag cagcaggttt tcgagtggaa     2400

ggacctggtg tccagcctgg ccagacggta catcggcaga tacggactgg cccacgtgtc     2460

caagtggaac ttcgagacct ggaacgagcc cgaccaccac gacttcgaca acgtgtcaat     2520

gaccatgcag ggctttctga actactacga cgcctgcagc gagggcctga gagctgcttc     2580

tcctgctctg agacttggcg gccctggcga ctcttttcac acccctccaa gaagccctct     2640

gtcctgggga ctgctgagac actgtcacga cggcaccaat ttcttcaccg gcgaggctgg     2700

cgtgcggctg gattatatca gcctgcacag aaagggcgcc agaagcagca tcagcatcct     2760

ggaacaagag aaggtggtgg cccagcagat cagacagctg ttccccaagt tcgccgacac     2820

acccatctac aacgacgagg ccgatcctct cgttggctgg tcacttcctc agccttggag     2880

agccgatgtg acctatgccg ccatggtggt caaagtgatc gcccagcacc agaatctgct     2940

gctcgccaat accaccagcg cctttccata cgctctgctg agcaacgaca acgccttcct     3000

gagctatcac cctcatcctt tcgctcagcg gaccctgacc gccagattcc aagtgaacaa     3060

cacccggcct ccacacgtgc agctgctgag aaaaccagtg ctgacagcca tgggcctgct     3120

cgccctgctg gacgaagaac aactgtgggc cgaagtgtcc caggccggaa cagtgctgga     3180

tagcaatcac acagtgggcg tgctggcctc cgctcataga cctcaaggac cagccgatgc     3240

ttggagggct gccgtgctga tctacgccag cgacgataca agggctcacc ccaacagatc     3300

cgtggccgtg acactgagac tgagaggcgt tccaccagga cctggcctgg tgtacgtgac     3360

cagatacctg gacaacggcc tgtgcagccc tgatggcgaa tggcgtagac taggcagacc     3420

tgtgtttcct accgccgagc agttcagacg gatgagagcc gctgaagatc ccgtggctgc     3480

tgctccaaga cctcttccag ctggtggcag actgactctg aggcctgcac tcagactgcc     3540

tagtctgctg ctggtgcacg tctgtgccag acctgagaag cctcctggcc aagtgacaag     3600

actgagggcc ctgccactga cacagggaca gctggttctt gtttggagcg acgagcacgt     3660

gggcagcaag tgtctgtgga cctacgagat ccagttcagc caggacggca aggcctacac     3720

acccgtgtct agaaagccta gcaccttcaa cctgttcgtg ttcagccccg atacaggcgc     3780

cgtgtctggc agctatagag tcagagccct ggactactgg gccagaccag gaccattttc     3840

tgaccccgtg ccttacctgg aagtgcccgt tcctagaggc cctccttctc ctggaaatcc     3900

ctgataaggt accagtgaat tctaccagtg ccataggata gtgaattcta ccagtgccat     3960

acacgtgagt gaattctacc agtgccatag catgcagtga attctaccag tgccatagcg     4020

gccgcctcga ggacggggtg aactacgcct gaggatccga tctttttccc tctgccaaaa     4080

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     4140

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagc aattcgttga     4200

tctgaatttc gaccacccat aatacccatt accctggtag ataagtagca tggcgggtta     4260

atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     4320

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     4380

tcagtgagcg agcgagcgcg cag                                             4403


<210>  16
<211>  2211
<212>  DNA
<213>  adeno-associated virus 9


<220>
<221>  CDS
<222>  (1)..(2211)

<400>  16
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctt agt         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa gga att cgc gag tgg tgg gct ttg aaa cct gga gcc cct caa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro           
            20                  25                  30                    

aag gca aat caa caa cat caa gac aac gct cga ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctt gga ccc ggc aac gga ctc gac aag ggg gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gca gca gac gcg gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc gga gac aac ccg tac ctc aag tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttc cag gag cgg ctc aaa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aaa aag agg ctt ctt gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro           
        115                 120                 125                       

ctt ggt ctg gtt gag gaa gcg gct aag acg gct cct gga aag aag agg        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tcc tcc gcg ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggt gca cag ccc gct aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac aca gag tca gtc cca gac cct caa cca atc gga gaa cct ccc        576
Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro           
            180                 185                 190                   

gca gcc ccc tca ggt gtg gga tct ctt aca atg gct tca ggt ggt ggc        624
Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca gtg gca gac aat aac gaa ggt gcc gat gga gtg ggt agt tcc        672
Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser           
    210                 215                 220                           

tcg gga aat tgg cat tgc gat tcc caa tgg ctg ggg gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aat cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc aac agc aca tct gga gga tct tca aat gac aac        816
Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn           
            260                 265                 270                   

gcc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac aga        864
Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg           
        275                 280                 285                       

ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctc atc aac aac        912
Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn           
    290                 295                 300                           

aac tgg gga ttc cgg cct aag cga ctc aac ttc aag ctc ttc aac att        960
Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile           
305                 310                 315                 320           

cag gtc aaa gag gtt acg gac aac aat gga gtc aag acc atc gcc aat       1008
Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn           
                325                 330                 335               

aac ctt acc agc acg gtc cag gtc ttc acg gac tca gac tat cag ctc       1056
Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu           
            340                 345                 350                   

ccg tac gtg ctc ggg tcg gct cac gag ggc tgc ctc ccg ccg ttc cca       1104
Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro           
        355                 360                 365                       

gcg gac gtt ttc atg att cct cag tac ggg tat ctg acg ctt aat gat       1152
Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp           
    370                 375                 380                           

gga agc cag gcc gtg ggt cgt tcg tcc ttt tac tgc ctg gaa tat ttc       1200
Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe           
385                 390                 395                 400           

ccg tcg caa atg cta aga acg ggt aac aac ttc cag ttc agc tac gag       1248
Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu           
                405                 410                 415               

ttt gag aac gta cct ttc cat agc agc tac gct cac agc caa agc ctg       1296
Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu           
            420                 425                 430                   

gac cga cta atg aat cca ctc atc gac caa tac ttg tac tat ctc tca       1344
Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser           
        435                 440                 445                       

aag act att aac ggt tct gga cag aat caa caa acg cta aaa ttc agt       1392
Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser           
    450                 455                 460                           

gtg gcc gga ccc agc aac atg gct gtc cag gga aga aac tac ata cct       1440
Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro           
465                 470                 475                 480           

gga ccc agc tac cga caa caa cgt gtc tca acc act gtg act caa aac       1488
Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn           
                485                 490                 495               

aac aac agc gaa ttt gct tgg cct gga gct tct tct tgg gct ctc aat       1536
Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn           
            500                 505                 510                   

gga cgt aat agc ttg atg aat cct gga cct gct atg gcc agc cac aaa       1584
Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys           
        515                 520                 525                       

gaa gga gag gac cgt ttc ttt cct ttg tct gga tct tta att ttt ggc       1632
Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly           
    530                 535                 540                           

aaa caa gga act gga aga gac aac gtg gat gcg gac aaa gtc atg ata       1680
Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile           
545                 550                 555                 560           

acc aac gaa gaa gaa att aaa act act aac ccg gta gca acg gag tcc       1728
Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser           
                565                 570                 575               

tat gga caa gtg gcc aca aac cac cag agt gcc caa gca cag gcg cag       1776
Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln           
            580                 585                 590                   

acc ggc tgg gtt caa aac caa gga ata ctt ccg ggt atg gtt tgg cag       1824
Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gat gtg tac ctg caa gga ccc att tgg gcc aaa att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gac ggc aac ttt cac cct tct ccg ctg atg gga ggg ttt gga atg       1920
Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac aca cct gta cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

gat cct cca acg gcc ttc aac aag gac aag ctg aac tct ttc atc acc       2016
Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr           
            660                 665                 670                   

cag tat tct act ggc caa gtc agc gtg gag atc gag tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aag gaa aac agc aag cgc tgg aac ccg gag atc cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tat tac aag tct aat aat gtt gaa ttt gct gtt aat act gaa ggt gta       2160
Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val           
705                 710                 715                 720           

tat agt gaa ccc cgc ccc att ggc acc aga tac ctg act cgt aat ctg       2208
Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu           
                725                 730                 735               

taa                                                                   2211


<210>  17
<211>  736
<212>  PRT
<213>  adeno-associated virus 9

<400>  17

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Gln Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln His Gln Asp Asn Ala Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Gly Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Leu Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ala Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Ala Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Thr Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Val Gly Ser Leu Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Val Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Gln Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Asn Ser Thr Ser Gly Gly Ser Ser Asn Asp Asn 
            260                 265                 270         


Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg 
        275                 280                 285             


Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn 
    290                 295                 300                 


Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile 
305                 310                 315                 320 


Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn 
                325                 330                 335     


Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu 
            340                 345                 350         


Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro 
        355                 360                 365             


Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp 
    370                 375                 380                 


Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe 
385                 390                 395                 400 


Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu 
                405                 410                 415     


Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu 
            420                 425                 430         


Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser 
        435                 440                 445             


Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser 
    450                 455                 460                 


Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro 
465                 470                 475                 480 


Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn 
                485                 490                 495     


Asn Asn Ser Glu Phe Ala Trp Pro Gly Ala Ser Ser Trp Ala Leu Asn 
            500                 505                 510         


Gly Arg Asn Ser Leu Met Asn Pro Gly Pro Ala Met Ala Ser His Lys 
        515                 520                 525             


Glu Gly Glu Asp Arg Phe Phe Pro Leu Ser Gly Ser Leu Ile Phe Gly 
    530                 535                 540                 


Lys Gln Gly Thr Gly Arg Asp Asn Val Asp Ala Asp Lys Val Met Ile 
545                 550                 555                 560 


Thr Asn Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr Glu Ser 
                565                 570                 575     


Tyr Gly Gln Val Ala Thr Asn His Gln Ser Ala Gln Ala Gln Ala Gln 
            580                 585                 590         


Thr Gly Trp Val Gln Asn Gln Gly Ile Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Met 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asp Pro Pro Thr Ala Phe Asn Lys Asp Lys Leu Asn Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Tyr Lys Ser Asn Asn Val Glu Phe Ala Val Asn Thr Glu Gly Val 
705                 710                 715                 720 


Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735     


<210>  18
<211>  1962
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1962)

<400>  18
atg cgt ccc ctg cgc ccc cgc gcc gcg ctg ctg gcg ctc ctg gcc tcg         48
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser           
1               5                   10                  15                

ctc ctg gcc gcg ccc ccg gtg gcc ccg gcc gag gcc ccg cac ctg gtg         96
Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val           
            20                  25                  30                    

cat gtg gac gcg gcc cgc gcg ctg tgg ccc ctg cgg cgc ttc tgg agg        144
His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg           
        35                  40                  45                        

agc aca ggc ttc tgc ccc ccg ctg cca cac agc cag gct gac cag tac        192
Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr           
    50                  55                  60                            

gtc ctc agc tgg gac cag cag ctc aac ctc gcc tat gtg ggc gcc gtc        240
Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val           
65                  70                  75                  80            

cct cac cgc ggc atc aag cag gtc cgg acc cac tgg ctg ctg gag ctt        288
Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu           
                85                  90                  95                

gtc acc acc agg ggg tcc act gga cgg ggc ctg agc tac aac ttc acc        336
Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr           
            100                 105                 110                   

cac ctg gac ggg tac ctg gac ctt ctc agg gag aac cag ctc ctc cca        384
His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro           
        115                 120                 125                       

ggg ttt gag ctg atg ggc agc gcc tcg ggc cac ttc act gac ttt gag        432
Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu           
    130                 135                 140                           

gac aag cag cag gtg ttt gag tgg aag gac ttg gtc tcc agc ctg gcc        480
Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala           
145                 150                 155                 160           

agg aga tac atc ggt agg tac gga ctg gcg cat gtt tcc aag tgg aac        528
Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn           
                165                 170                 175               

ttc gag acg tgg aat gag cca gac cac cac gac ttt gac aac gtc tcc        576
Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser           
            180                 185                 190                   

atg acc atg caa ggc ttc ctg aac tac tac gat gcc tgc tcg gag ggt        624
Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly           
        195                 200                 205                       

ctg cgc gcc gcc agc ccc gcc ctg cgg ctg gga ggc ccc ggc gac tcc        672
Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser           
    210                 215                 220                           

ttc cac acc cca ccg cga tcc ccg ctg agc tgg ggc ctc ctg cgc cac        720
Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His           
225                 230                 235                 240           

tgc cac gac ggt acc aac ttc ttc act ggg gag gcg ggc gtg cgg ctg        768
Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu           
                245                 250                 255               

gac tac atc tcc ctc cac agg aag ggt gcg cgc agc tcc atc tcc atc        816
Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile           
            260                 265                 270                   

ctg gag cag gag aag gtc gtc gcg cag cag atc cgg cag ctc ttc ccc        864
Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro           
        275                 280                 285                       

aag ttc gcg gac acc ccc att tac aac gac gag gcg gac ccg ctg gtg        912
Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val           
    290                 295                 300                           

ggc tgg tcc ctg cca cag ccg tgg agg gcg gac gtg acc tac gcg gcc        960
Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala           
305                 310                 315                 320           

atg gtg gtg aag gtc atc gcg cag cat cag aac ctg cta ctg gcc aac       1008
Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn           
                325                 330                 335               

acc acc tcc gcc ttc ccc tac gcg ctc ctg agc aac gac aat gcc ttc       1056
Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe           
            340                 345                 350                   

ctg agc tac cac ccg cac ccc ttc gcg cag cgc acg ctc acc gcg cgc       1104
Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg           
        355                 360                 365                       

ttc cag gtc aac aac acc cgc ccg ccg cac gtg cag ctg ttg cgc aag       1152
Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys           
    370                 375                 380                           

ccg gtg ctc acg gcc atg ggg ctg ctg gcg ctg ctg gat gag gag cag       1200
Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln           
385                 390                 395                 400           

ctc tgg gcc gaa gtg tcg cag gcc ggg acc gtc ctg gac agc aac cac       1248
Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His           
                405                 410                 415               

acg gtg ggc gtc ctg gcc agc gcc cac cgc ccc cag ggc ccg gcc gac       1296
Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp           
            420                 425                 430                   

gcc tgg cgc gcc gcg gtg ctg atc tac gcg agc gac gac acc cgc gcc       1344
Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala           
        435                 440                 445                       

cac ccc aac cgc agc gtc gcg gtg acc ctg cgg ctg cgc ggg gtg ccc       1392
His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro           
    450                 455                 460                           

ccc ggc ccg ggc ctg gtc tac gtc acg cgc tac ctg gac aac ggg ctc       1440
Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu           
465                 470                 475                 480           

tgc agc ccc gac ggc gag tgg cgg cgc ctg ggc cgg ccc gtc ttc ccc       1488
Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro           
                485                 490                 495               

acg gca gag cag ttc cgg cgc atg cgc gcg gct gag gac ccg gtg gcc       1536
Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala           
            500                 505                 510                   

gcg gcg ccc cgc ccc tta ccc gcc ggc ggc cgc ctg acc ctg cgc ccc       1584
Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro           
        515                 520                 525                       

gcg ctg cgg ctg ccg tcg ctt ttg ctg gtg cac gtg tgt gcg cgc ccc       1632
Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro           
    530                 535                 540                           

gag aag ccg ccc ggg cag gtc acg cgg ctc cgc gcc ctg ccc ctg acc       1680
Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr           
545                 550                 555                 560           

caa ggg cag ctg gtt ctg gtc tgg tcg gat gaa cac gtg ggc tcc aag       1728
Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys           
                565                 570                 575               

tgc ctg tgg aca tac gag atc cag ttc tct cag gac ggt aag gcg tac       1776
Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr           
            580                 585                 590                   

acc ccg gtc agc agg aag cca tcg acc ttc aac ctc ttt gtg ttc agc       1824
Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser           
        595                 600                 605                       

cca gac aca ggt gct gtc tct ggc tcc tac cga gtt cga gcc ctg gac       1872
Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp           
    610                 615                 620                           

tac tgg gcc cga cca ggc ccc ttc tcg gac cct gtg ccg tac ctg gag       1920
Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu           
625                 630                 635                 640           

gtc cct gtg cca aga ggg ccc cca tcc ccg ggc aat cca tga               1962
Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro                       
                645                 650                                   


<210>  19
<211>  653
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  20
<211>  3106
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CB7.CI.eGFP.miR183(1x).RBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  AAV2 - 5' ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  human cytomegalovirus (CMV) immediate early (IE) enhancer

<220>
<221>  promoter
<222>  (582)..(862)
<223>  chicken beta-actin (CB) promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin intron

<220>
<221>  Misc
<222>  (1977)..(2696)
<223>  eGFP coding sequence

<220>
<221>  misc_RNA
<222>  (2699)..(2720)
<223>  miR183

<220>
<221>  polyA_signal
<222>  (2762)..(2888)
<223>  rabbit globin polyA

<220>
<221>  repeat_region
<222>  (2977)..(3106)
<223>  AAV2 - 3' ITR

<400>  20
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttacttaata cgactcacta taggctagta atacgactca ctatagatgg     1980

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     2040

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     2100

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     2160

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     2220

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     2280

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     2340

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     2400

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     2460

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     2520

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     2580

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     2640

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaagcag     2700

tgaattctac cagtgccata gcggccgcct cgaggacggg gtgaactacg cctgaggatc     2760

cgatcttttt ccctctgcca aaaattatgg ggacatcatg aagccccttg agcatctgac     2820

ttctggctaa taaaggaaat ttattttcat tgcaatagtg tgttggaatt ttttgtgtct     2880

ctcactcgga agcaattcgt tgatctgaat ttcgaccacc cataataccc attaccctgg     2940

tagataagta gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg     3000

ccactccctc tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac     3060

gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc gcgcag                    3106


<210>  21
<211>  3136
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CB7.CI.eGFP.miRNA183(2x).RBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  AAV 2 - 5' ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  hCMV IE enhancer

<220>
<221>  promoter
<222>  (582)..(862)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1977)..(2696)
<223>  eGFP coding sequence

<220>
<221>  misc_RNA
<222>  (2701)..(2722)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2701)..(2722)
<223>  spacer

<220>
<221>  misc_feature
<222>  (2723)..(2728)
<223>  spacer

<220>
<221>  misc_RNA
<222>  (2729)..(2750)
<223>  miRNA183

<220>
<221>  polyA_signal
<222>  (2792)..(2916)
<223>  rabbit globin polyA

<400>  21
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttacttaata cgactcacta taggctagta atacgactca ctatagatgg     1980

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     2040

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     2100

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     2160

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     2220

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     2280

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     2340

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     2400

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     2460

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     2520

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     2580

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     2640

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaggtg     2700

agtgaattct accagtgcca tagcatgcag tgaattctac cagtgccata gcggccgcct     2760

cgaggacggg gtgaactacg cctgaggatc cgatcttttt ccctctgcca aaaattatgg     2820

ggacatcatg aagccccttg agcatctgac ttctggctaa taaaggaaat ttattttcat     2880

tgcaatagtg tgttggaatt ttttgtgtct ctcactcgga agcaattcgt tgatctgaat     2940

ttcgaccacc cataataccc attaccctgg tagataagta gcatggcggg ttaatcatta     3000

actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca     3060

ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga     3120

gcgagcgagc gcgcag                                                     3136


<210>  22
<211>  3163
<212>  DNA
<213>  Artificial sequence

<220>
<223>  CB7.CI.eGFP.miRNA183(3x).RBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  AAV2 - 5' ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  promoter
<222>  (582)..(862)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin promoter

<220>
<221>  misc_feature
<222>  (1977)..(2696)
<223>  eGFP coding sequence

<220>
<221>  misc_RNA
<222>  (2703)..(2724)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2725)..(2728)
<223>  spacer

<220>
<221>  misc_RNA
<222>  (2729)..(2750)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2751)..(2756)
<223>  spacer

<220>
<221>  misc_RNA
<222>  (2757)..(2778)
<223>  miRNA183

<220>
<221>  polyA_signal
<222>  (2819)..(2945)
<223>  rabbit globin polyA

<220>
<221>  repeat_region
<222>  (3034)..(3163)

<400>  22
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttacttaata cgactcacta taggctagta atacgactca ctatagatgg     1980

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     2040

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     2100

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     2160

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     2220

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     2280

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     2340

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     2400

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     2460

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     2520

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     2580

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     2640

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaggta     2700

ccagtgaatt ctaccagtgc cataggatag tgaattctac cagtgccata cacgtgagtg     2760

aattctacca gtgccatagg gccgcctcga ggacggggtg aactacgcct gaggatccga     2820

tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc     2880

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     2940

actcggaagc aattcgttga tctgaatttc gaccacccat aatacccatt accctggtag     3000

ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca     3060

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     3120

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag                       3163


<210>  23
<211>  3192
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CB7.CI.eGFP.miRNA183.RBG


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  AAV2 = 5' ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  hCMV IE enhancer

<220>
<221>  promoter
<222>  (582)..(862)
<223>  CB promoter

<220>
<221>  Intron
<222>  (956)..(1926)
<223>  chicken betan-actin intron

<220>
<221>  misc_feature
<222>  (1977)..(2696)
<223>  eGFP coding sequence

<220>
<221>  misc_RNA
<222>  (2703)..(2724)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2725)..(2729)
<223>  spacer

<220>
<221>  misc_RNA
<222>  (2729)..(2750)
<223>  miRNA183

<220>
<221>  misc_RNA
<222>  (2757)..(2778)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (2779)..(2784)
<223>  spacer

<220>
<221>  misc_RNA
<222>  (2785)..(2806)
<223>  miRNA183

<220>
<221>  polyA_signal
<222>  (2848)..(2974)
<223>  rabbit globin polyA

<220>
<221>  repeat_region
<222>  (3063)..(3192)
<223>  AAV2 - 3' ITR

<400>  23
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttacttaata cgactcacta taggctagta atacgactca ctatagatgg     1980

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     2040

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     2100

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     2160

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     2220

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     2280

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     2340

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     2400

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     2460

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     2520

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     2580

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     2640

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaggta     2700

ccagtgaatt ctaccagtgc cataggatag tgaattctac cagtgccata cacgtgagtg     2760

aattctacca gtgccatagc atgcagtgaa ttctaccagt gccatagcgg ccgcctcgag     2820

gacggggtga actacgcctg aggatccgat ctttttccct ctgccaaaaa ttatggggac     2880

atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat tttcattgca     2940

atagtgtgtt ggaatttttt gtgtctctca ctcggaagca attcgttgat ctgaatttcg     3000

accacccata atacccatta ccctggtaga taagtagcat ggcgggttaa tcattaacta     3060

caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct cgctcactga     3120

ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct cagtgagcga     3180

gcgagcgcgc ag                                                         3192


<210>  24
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  LAGLIDADG

<400>  24

Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210>  25
<211>  22
<212>  DNA
<213>  Artificial sequence

<220>
<223>  endonuclease recognition site

<400>  25
caaaacgtcg tgagacagtt tg                                                22


<210>  26
<211>  3283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  promoter
<222>  (582)..(862)
<223>  CB promoter

<220>
<221>  TATA_signal
<222>  (836)..(839)
<223>  TATA

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1977)..(2696)
<223>  eGFP

<220>
<221>  misc_feature
<222>  (2729)..(2760)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2757)..(2778)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2785)..(2806)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2815)..(2836)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2858)..(2879)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2884)..(2905)
<223>  miR183

<220>
<221>  polyA_signal
<222>  (2939)..(3065)
<223>  Rabbit globin poly A

<220>
<221>  repeat_region
<222>  (3154)..(3283)
<223>  3' ITR

<400>  26
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttacttaata cgactcacta taggctagta atacgactca ctatagatgg     1980

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     2040

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     2100

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     2160

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     2220

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     2280

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     2340

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     2400

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     2460

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     2520

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     2580

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     2640

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaggta     2700

ccagtgaatt ctaccagtgc cataggatag tgaattctac cagtgccata cacgtgagtg     2760

aattctacca gtgccatagc atgcagtgaa ttctaccagt gccatagcgg ccgcagtgaa     2820

ttctaccagt gccatatcac agtgaattct aaccggtagt gaattctacc agtgccatat     2880

cacagtgaat tctaccagtg ccatactcga ggacggggtg aactacgcct gaggatccga     2940

tctttttccc tctgccaaaa attatgggga catcatgaag ccccttgagc atctgacttc     3000

tggctaataa aggaaattta ttttcattgc aatagtgtgt tggaattttt tgtgtctctc     3060

actcggaagc aattcgttga tctgaatttc gaccacccat aatacccatt accctggtag     3120

ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca     3180

ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc     3240

cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag                       3283


<210>  27
<211>  3294
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  promoter
<222>  (582)..(862)
<223>  CB promoter

<220>
<221>  TATA_signal
<222>  (836)..(839)

<220>
<221>  Intron
<222>  (956)..(1928)
<223>  chicken beta-actin intron

<220>
<221>  misc_feature
<222>  (1977)..(2696)
<223>  eGFP

<220>
<221>  misc_feature
<222>  (2703)..(2724)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2729)..(2750)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2757)..(2778)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2785)..(2806)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2815)..(2836)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2841)..(2862)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2869)..(2890)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2895)..(2916)
<223>  miR183

<220>
<221>  polyA_signal
<222>  (2950)..(3076)
<223>  Rabbit globin poly A

<220>
<221>  repeat_region
<222>  (3165)..(3294)
<223>  3 ' ITR

<400>  27
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc      900

cgccgccgcc tcgcgccgcc cgccccggct ctgactgacc gcgttactcc cacaggtgag      960

cgggcgggac ggcccttctc ctccgggctg taattagcgc ttggtttaat gacggcttgt     1020

ttcttttctg tggctgcgtg aaagccttga ggggctccgg gagggccctt tgtgcggggg     1080

gagcggctcg gggggtgcgt gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc     1140

gctgcccggc ggctgtgagc gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt     1200

gcgcgagggg agcgcggccg ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa     1260

caaaggctgc gtgcggggtg tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt     1320

cgggctgcaa ccccccctgc acccccctcc ccgagttgct gagcacggcc cggcttcggg     1380

tgcggggctc cgtacggggc gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca     1440

ggtgggggtg ccgggcgggg cggggccgcc tcgggccggg gagggctcgg gggaggggcg     1500

cggcggcccc cggagcgccg gcggctgtcg aggcgcggcg agccgcagcc attgcctttt     1560

atggtaatcg tgcgagaggg cgcagggact tcctttgtcc caaatctgtg cggagccgaa     1620

atctgggagg cgccgccgca ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg     1680

caggaaggaa atgggcgggg agggccttcg tgcgtcgccg cgccgccgtc cccttctccc     1740

tctccagcct cggggctgtc cgcgggggga cggctgcctt cgggggggac ggggcagggc     1800

ggggttcggc ttctggcgtg tgaccggcgg ctctagagcc tctgctaacc atgttcatgc     1860

cttcttcttt ttcctacagc tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt     1920

tggcaaagaa ttacttaata cgactcacta taggctagta atacgactca ctatagatgg     1980

tgagcaaggg cgaggagctg ttcaccgggg tggtgcccat cctggtcgag ctggacggcg     2040

acgtaaacgg ccacaagttc agcgtgtccg gcgagggcga gggcgatgcc acctacggca     2100

agctgaccct gaagttcatc tgcaccaccg gcaagctgcc cgtgccctgg cccaccctcg     2160

tgaccaccct gacctacggc gtgcagtgct tcagccgcta ccccgaccac atgaagcagc     2220

acgacttctt caagtccgcc atgcccgaag gctacgtcca ggagcgcacc atcttcttca     2280

aggacgacgg caactacaag acccgcgccg aggtgaagtt cgagggcgac accctggtga     2340

accgcatcga gctgaagggc atcgacttca aggaggacgg caacatcctg gggcacaagc     2400

tggagtacaa ctacaacagc cacaacgtct atatcatggc cgacaagcag aagaacggca     2460

tcaaggtgaa cttcaagatc cgccacaaca tcgaggacgg cagcgtgcag ctcgccgacc     2520

actaccagca gaacaccccc atcggcgacg gccccgtgct gctgcccgac aaccactacc     2580

tgagcaccca gtccgccctg agcaaagacc ccaacgagaa gcgcgatcac atggtcctgc     2640

tggagttcgt gaccgccgcc gggatcactc tcggcatgga cgagctgtac aagtaaggta     2700

ccagtgaatt ctaccagtgc cataggatag tgaattctac cagtgccata cacgtgagtg     2760

aattctacca gtgccatagc atgcagtgaa ttctaccagt gccatagcgg ccgcagtgaa     2820

ttctaccagt gccatacgat agtgaattct accagtgcca taaccggtag tgaattctac     2880

cagtgccata tcacagtgaa ttctaccagt gccatactcg aggacggggt gaactacgcc     2940

tgaggatccg atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     3000

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     3060

ttgtgtctct cactcggaag caattcgttg atctgaattt cgaccaccca taatacccat     3120

taccctggta gataagtagc atggcgggtt aatcattaac tacaaggaac ccctagtgat     3180

ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt     3240

cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc gcag           3294


<210>  28
<211>  3304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  enhancer
<222>  (198)..(579)
<223>  CMV IE enhancer

<220>
<221>  promoter
<222>  (582)..(863)
<223>  CB promoter

<220>
<221>  TATA_signal
<222>  (836)..(839)
<223>  TATA

<220>
<221>  misc_feature
<222>  (836)..(2698)
<223>  eGFP

<220>
<221>  Intron
<222>  (958)..(1930)

<220>
<221>  misc_feature
<222>  (2705)..(2728)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2733)..(2756)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2763)..(2786)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2793)..(2816)
<223>  miR182

<220>
<221>  misc_feature
<222>  (2825)..(2846)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2851)..(2872)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2879)..(2900)
<223>  miR183

<220>
<221>  misc_feature
<222>  (2905)..(2926)
<223>  miR183

<220>
<221>  polyA_signal
<222>  (2960)..(3086)
<223>  Rabbit globin poly A

<220>
<221>  repeat_region
<222>  (3175)..(3304)
<223>  3' ITR

<400>  28
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctaccag ggtaatgggg      180

atcctctaga actatagcta gtcgacattg attattgact agttattaat agtaatcaat      240

tacggggtca ttagttcata gcccatatat ggagttccgc gttacataac ttacggtaaa      300

tggcccgcct ggctgaccgc ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt      360

tcccatagta acgccaatag ggactttcca ttgacgtcaa tgggtggagt atttacggta      420

aactgcccac ttggcagtac atcaagtgta tcatatgcca agtacgcccc ctattgacgt      480

caatgacggt aaatggcccg cctggcatta tgcccagtac atgaccttat gggactttcc      540

tacttggcag tacatctacg tattagtcat cgctattacc atggtcgagg tgagccccac      600

gttctgcttc actctcccca tctccccccc ctccccaccc ccaattttgt atttatttat      660

tttttaatta ttttgtgcag cgatgggggc gggggggggg ggggggcgcg cgccaggcgg      720

ggcggggcgg ggcgaggggc ggggcggggc gaggcggaga ggtgcggcgg cagccaatca      780

gagcggcgcg ctccgaaagt ttccttttat ggcgaggcgg cggcggcggc ggccctataa      840

aaagcgaagc gcgcggcggg cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc      900

tccgccgccg cctcgcgccg cccgccccgg ctctgactga ccgcgttact cccacaggtg      960

agcgggcggg acggcccttc tcctccgggc tgtaattagc gcttggttta atgacggctt     1020

gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc gggagggccc tttgtgcggg     1080

gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc     1140

gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt     1200

gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt gcgggggggg ctgcgagggg     1260

aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg     1320

gtcgggctgc aaccccccct gcacccccct ccccgagttg ctgagcacgg cccggcttcg     1380

ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg     1440

caggtggggg tgccgggcgg ggcggggccg cctcgggccg gggagggctc gggggagggg     1500

cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt     1560

ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt cccaaatctg tgcggagccg     1620

aaatctggga ggcgccgccg caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc     1680

ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc     1740

cctctccagc ctcggggctg tccgcggggg gacggctgcc ttcggggggg acggggcagg     1800

gcggggttcg gcttctggcg tgtgaccggc ggctctagag cctctgctaa ccatgttcat     1860

gccttcttct ttttcctaca gctcctgggc aacgtgctgg ttattgtgct gtctcatcat     1920

tttggcaaag aattacttaa tacgactcac tataggctag taatacgact cactatagat     1980

ggtgagcaag ggcgaggagc tgttcaccgg ggtggtgccc atcctggtcg agctggacgg     2040

cgacgtaaac ggccacaagt tcagcgtgtc cggcgagggc gagggcgatg ccacctacgg     2100

caagctgacc ctgaagttca tctgcaccac cggcaagctg cccgtgccct ggcccaccct     2160

cgtgaccacc ctgacctacg gcgtgcagtg cttcagccgc taccccgacc acatgaagca     2220

gcacgacttc ttcaagtccg ccatgcccga aggctacgtc caggagcgca ccatcttctt     2280

caaggacgac ggcaactaca agacccgcgc cgaggtgaag ttcgagggcg acaccctggt     2340

gaaccgcatc gagctgaagg gcatcgactt caaggaggac ggcaacatcc tggggcacaa     2400

gctggagtac aactacaaca gccacaacgt ctatatcatg gccgacaagc agaagaacgg     2460

catcaaggtg aacttcaaga tccgccacaa catcgaggac ggcagcgtgc agctcgccga     2520

ccactaccag cagaacaccc ccatcggcga cggccccgtg ctgctgcccg acaaccacta     2580

cctgagcacc cagtccgccc tgagcaaaga ccccaacgag aagcgcgatc acatggtcct     2640

gctggagttc gtgaccgccg ccgggatcac tctcggcatg gacgagctgt acaagtaagg     2700

taccagtgtg agttctacca ttgccaaagg atagtgtgag ttctaccatt gccaaacacg     2760

tgagtgtgag ttctaccatt gccaaagcat gcagtgtgag ttctaccatt gccaaagcgg     2820

ccgcagtgaa ttctaccagt gccatacgat agtgaattct accagtgcca taaccggtag     2880

tgaattctac cagtgccata tcacagtgaa ttctaccagt gccatactcg aggacggggt     2940

gaactacgcc tgaggatccg atctttttcc ctctgccaaa aattatgggg acatcatgaa     3000

gccccttgag catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg     3060

ttggaatttt ttgtgtctct cactcggaag caattcgttg atctgaattt cgaccaccca     3120

taatacccat taccctggta gataagtagc atggcgggtt aatcattaac tacaaggaac     3180

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgggc     3240

gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc gagcgagcgc     3300

gcag                                                                  3304


