                               SEQUENCE LISTING

<110> RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL
 
<120> GENE THERAPY WITH DYSFERLIN DUAL VECTORS

<130> 106887-8070

<140>
<141>

<150> 63/024,338
<151> 2020-05-13

<160> 22    

<170> PatentIn version 3.5

<210> 1
<211> 3340
<212> DNA
<213> Homo sapiens

<220>
<223> 5' hDYSF DNA fragment v1

<400> 1
atgctgaggg tcttcatcct ctatgccgag aacgtccaca cacccgacac cgacatcagc       60

gatgcctact gctccgcggt gtttgcaggg gtgaagaaga gaaccaaagt catcaagaac      120

agcgtgaacc ctgtatggaa tgagggattt gaatgggacc tcaagggcat ccccctggac      180

cagggctctg agcttcatgt ggtggtcaaa gaccatgaga cgatggggag gaacaggttc      240

ctgggggaag ccaaggtccc actccgagag gtcctcgcca cccctagtct gtccgccagc      300

ttcaatgccc ccctgctgga caccaagaag cagcccacag gggcctcgct ggtcctgcag      360

gtgtcctaca caccgctgcc tggagctgtg cccctgttcc cgccccctac tcctctggag      420

ccctccccga ctctgcctga cctggatgta gtggcagaca caggaggaga ggaagacaca      480

gaggaccagg gactcactgg agatgaggcg gagccattcc tggatcaaag cggaggcccg      540

ggggctccca ccaccccaag gaaactacct tcacgtcctc cgccccacta ccccgggatc      600

aaaagaaagc gaagtgcgcc tacatctaga aagctgctgt cagacaaacc gcaggatttc      660

cagatcaggg tccaggtgat cgaggggcgc cagctgccgg gggtgaacat caagcctgtg      720

gtcaaggtta ccgctgcagg gcagaccaag cggacgcgga tccacaaggg aaacagccca      780

ctcttcaatg agactctttt cttcaacttg tttgactctc ctggggagct gtttgatgag      840

cccatcttta tcacggtggt agactctcgt tctctcagga cagatgctct cctcggggag      900

ttccggatgg acgtgggcac catttacaga gagccccggc acgcctatct caggaagtgg      960

ctgctgctct cagaccctga tgacttctct gctggggcca gaggctacct gaaaacaagc     1020

ctttgtgtgc tggggcctgg ggacgaagcg cctctggaga gaaaagaccc ctctgaagac     1080

aaggaggaca ttgaaagcaa cctgctccgg cccacaggcg tagccctgcg aggagcccac     1140

ttctgcctga aggtcttccg ggccgaggac ttgccgcaga tggacgatgc cgtgatggac     1200

aacgtgaaac agatctttgg cttcgagagt aacaagaaga acttggtgga cccctttgtg     1260

gaggtcagct ttgcggggaa aatgctgtgc agcaagatct tggagaagac ggccaaccct     1320

cagtggaacc agaacatcac actgcctgcc atgtttccct ccatgtgcga aaaaatgagg     1380

attcgtatca tagactggga ccgcctgact cacaatgaca tcgtggctac cacctacctg     1440

agtatgtcga aaatctctgc ccctggagga gaaatagaag aggagcctgc aggtgctgtc     1500

aagccttcga aagcctcaga cttggatgac tacctgggct tcctccccac ttttgggccc     1560

tgctacatca acctctatgg cagtcccaga gagttcacag gcttcccaga cccctacaca     1620

gagctcaaca caggcaaggg ggaaggtgtg gcttatcgtg gccggcttct gctctccctg     1680

gagaccaagc tggtggagca cagtgaacag aaggtggagg accttcctgc ggatgacatc     1740

ctccgggtgg agaagtacct taggaggcgc aagtactccc tgtttgcggc cttctactca     1800

gccaccatgc tgcaggatgt ggatgatgcc atccagtttg aggtcagcat cgggaactac     1860

gggaacaagt tcgacatgac ctgcctgccg ctggcctcca ccactcagta cagccgtgca     1920

gtctttgacg ggtgccacta ctactaccta ccctggggta acgtgaaacc tgtggtggtg     1980

ctgtcatcct actgggagga catcagccat agaatcgaga ctcagaacca gctgcttggg     2040

attgctgacc ggctggaagc tggcctggag caggtccacc tggccctgaa ggcgcagtgc     2100

tccacggagg acgtggactc gctggtggct cagctgacgg atgagctcat cgcaggctgc     2160

agccagcctc tgggtgacat ccatgagaca ccctctgcca cccacctgga ccagtacctg     2220

taccagctgc gcacccatca cctgagccaa atcactgagg ctgccctggc cctgaagctc     2280

ggccacagtg agctccctgc agctctggag caggcggagg actggctcct gcgtctgcgt     2340

gccctggcag aggagcccca gaacagcctg ccggacatcg tcatctggat gctgcaggga     2400

gacaagcgtg tggcatacca gcgggtgccc gcccaccaag tcctcttctc ccggcggggt     2460

gccaactact gtggcaagaa ttgtgggaag ctacagacaa tctttctgaa atatccgatg     2520

gagaaggtgc ctggcgcccg gatgccagtg cagatacggg tcaagctgtg gtttgggctc     2580

tctgtggatg agaaggagtt caaccagttt gctgagggga agctgtctgt ctttgctgaa     2640

acctatgaga acgagactaa gttggccctt gttgggaact ggggcacaac gggcctcacc     2700

taccccaagt tttctgacgt cacgggcaag atcaagctac ccaaggacag cttccgcccc     2760

tcggccggct ggacctgggc tggagattgg ttcgtgtgtc cggagaagac tctgctccat     2820

gacatggacg ccggtcacct gagcttcgtg gaagaggtgt ttgagaacca gacccggctt     2880

cccggaggcc agtggatcta catgagtgac aactacaccg atgtgaacgg ggagaaggtg     2940

cttcccaagg atgacattga gtgcccactg ggctggaagt gggaagatga ggaatggtcc     3000

acagacctca accgggctgt cgatgagcaa ggctgggagt atagcatcac catccccccg     3060

gagcggaagc cgaagcactg ggtccctgct gagaagatgt actacacaca ccgacggcgg     3120

cgctgggtgc gcctgcgcag gagggatctc agccaaatgg aagcactgaa aaggcacagg     3180

caggcggagg cggagggcga gggctgggag tacgcctctc tttttggctg gaagttccac     3240

ctcgagtacc gcaagacaga tgccttccgc cgccgccgct ggcgccgtcg catggagcca     3300

ctggagaaga cggggcctgc agctgtgttt gcccttgagg                           3340


<210> 2
<211> 3866
<212> DNA
<213> Homo sapiens

<220>
<223> 3' hDYSF DNA fragment v1

<400> 2
tcgtcatctg gatgctgcag ggagacaagc gtgtggcata ccagcgggtg cccgcccacc       60

aagtcctctt ctcccggcgg ggtgccaact actgtggcaa gaattgtggg aagctacaga      120

caatctttct gaaatatccg atggagaagg tgcctggcgc ccggatgcca gtgcagatac      180

gggtcaagct gtggtttggg ctctctgtgg atgagaagga gttcaaccag tttgctgagg      240

ggaagctgtc tgtctttgct gaaacctatg agaacgagac taagttggcc cttgttggga      300

actggggcac aacgggcctc acctacccca agttttctga cgtcacgggc aagatcaagc      360

tacccaagga cagcttccgc ccctcggccg gctggacctg ggctggagat tggttcgtgt      420

gtccggagaa gactctgctc catgacatgg acgccggtca cctgagcttc gtggaagagg      480

tgtttgagaa ccagacccgg cttcccggag gccagtggat ctacatgagt gacaactaca      540

ccgatgtgaa cggggagaag gtgcttccca aggatgacat tgagtgccca ctgggctgga      600

agtgggaaga tgaggaatgg tccacagacc tcaaccgggc tgtcgatgag caaggctggg      660

agtatagcat caccatcccc ccggagcgga agccgaagca ctgggtccct gctgagaaga      720

tgtactacac acaccgacgg cggcgctggg tgcgcctgcg caggagggat ctcagccaaa      780

tggaagcact gaaaaggcac aggcaggcgg aggcggaggg cgagggctgg gagtacgcct      840

ctctttttgg ctggaagttc cacctcgagt accgcaagac agatgccttc cgccgccgcc      900

gctggcgccg tcgcatggag ccactggaga agacggggcc tgcagctgtg tttgcccttg      960

agggggccct gggcggcgtg atggatgaca agagtgaaga ttccatgtcc gtctccacct     1020

tgagcttcgg tgtgaacaga cccacgattt cctgcatatt cgactatggg aaccgctacc     1080

atctacgctg ctacatgtac caggcccggg acctggctgc gatggacaag gactcttttt     1140

ctgatcccta tgccatcgtc tccttcctgc accagagcca gaagacggtg gtggtgaaga     1200

acacccttaa ccccacctgg gaccagacgc tcatcttcta cgagatcgag atctttggcg     1260

agccggccac agttgctgag caaccgccca gcattgtggt ggagctgtac gaccatgaca     1320

cttatggtgc agacgagttt atgggtcgct gcatctgtca accgagtctg gaacggatgc     1380

cacggctggc ctggttccca ctgacgaggg gcagccagcc gtcgggggag ctgctggcct     1440

cttttgagct catccagaga gagaagccgg ccatccacca tattcctggt tttgaggtgc     1500

aggagacatc aaggatcctg gatgagtctg aggacacaga cctgccctac ccaccacccc     1560

agagggaggc caacatctac atggttcctc agaacatcaa gccagcgctc cagcgtaccg     1620

ccatcgagat cctggcatgg ggcctgcgga acatgaagag ttaccagctg gccaacatct     1680

cctcccccag cctcgtggta gagtgtgggg gccagacggt gcagtcctgt gtcatcagga     1740

acctccggaa gaaccccaac tttgacatct gcaccctctt catggaagtg atgctgccca     1800

gggaggagct ctactgcccc cccatcaccg tcaaggtcat cgataaccgc cagtttggcc     1860

gccggcctgt ggtgggccag tgtaccatcc gctccctgga gagcttcctg tgtgacccct     1920

actcggcgga gagtccatcc ccacagggtg gcccagacga tgtgagccta ctcagtcctg     1980

gggaagacgt gctcatcgac attgatgaca aggagcccct catccccatc caggaggaag     2040

agttcatcga ttggtggagc aaattctttg cctccatagg ggagagggaa aagtgcggct     2100

cctacctgga gaaggatttt gacaccctga aggtctatga cacacagctg gagaatgtgg     2160

aggcctttga gggcctgtct gacttttgta acaccttcaa gctgtaccgg ggcaagacgc     2220

aggaggagac agaagatcca tctgtgattg gtgaatttaa gggcctcttc aaaatttatc     2280

ccctcccaga agacccagcc atccccatgc ccccaagaca gttccaccag ctggccgccc     2340

agggacccca ggagtgcttg gtccgtatct acattgtccg agcatttggc ctgcagccca     2400

aggaccccaa tggaaagtgt gatccttaca tcaagatctc catagggaag aaatcagtga     2460

gtgaccagga taactacatc ccctgcacgc tggagcccgt atttggaaag atgttcgagc     2520

tgacctgcac tctgcctctg gagaaggacc taaagatcac tctctatgac tatgacctcc     2580

tctccaagga cgaaaagatc ggtgagacgg tcgtcgacct ggagaacagg ctgctgtcca     2640

agtttggggc tcgctgtgga ctcccacaga cctactgtgt ctctggaccg aaccagtggc     2700

gggaccagct ccgcccctcc cagctcctcc acctcttctg ccagcagcat agagtcaagg     2760

cacctgtgta ccggacagac cgtgtaatgt ttcaggataa agaatattcc attgaagaga     2820

tagaggctgg caggatccca aacccacacc tgggcccagt ggaggagcgt ctggctctgc     2880

atgtgcttca gcagcagggc ctggtcccgg agcacgtgga gtcacggccc ctctacagcc     2940

ccctgcagcc agacatcgag caggggaagc tgcagatgtg ggtcgaccta tttccgaagg     3000

ccctggggcg gcctggacct cccttcaaca tcaccccacg gagagccaga aggtttttcc     3060

tgcgttgtat tatctggaat accagagatg tgatcctgga tgacctgagc ctcacggggg     3120

agaagatgag cgacatttat gtgaaaggtt ggatgattgg ctttgaagaa cacaagcaaa     3180

agacagacgt gcattatcgt tccctgggag gtgaaggcaa cttcaactgg aggttcattt     3240

tccccttcga ctacctgcca gctgagcaag tctgtaccat tgccaagaag gatgccttct     3300

ggaggctgga caagactgag agcaaaatcc cagcacgagt ggtgttccag atctgggaca     3360

atgacaagtt ctcctttgat gattttctgg gctccctgca gctcgatctc aaccgcatgc     3420

ccaagccagc caagacagcc aagaagtgct ccttggacca gctggatgat gctttccacc     3480

cagaatggtt tgtgtccctt tttgagcaga aaacagtgaa gggctggtgg ccctgtgtag     3540

cagaagaggg tgagaagaaa atactggcgg gcaagctgga aatgaccttg gagattgtag     3600

cagagagtga gcatgaggag cggcctgctg gccagggccg ggatgagccc aacatgaacc     3660

ctaagcttga ggacccaagg cgccccgaca cctccttcct gtggtttacc tccccataca     3720

agaccatgaa gttcatcctg tggcggcgtt tccggtgggc catcatcctc ttcatcatcc     3780

tcttcatcct gctgctgttc ctggccatct tcatctacgc cttcccgaac tatgctgcca     3840

tgaagctggt gaagcccttc agctga                                          3866


<210> 3
<211> 128
<212> DNA
<213> Adeno-associated virus 2

<220>
<223> ITR

<400> 3
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttcct                                                               128


<210> 4
<211> 792
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> promoter

<400> 4
aagcttgcat gtctaagcta gacccttcag attaaaaata actgaggtaa gggcctgggt       60

aggggaggtg gtgtgagacg ctcctgtctc tcctctatct gcccatcggc cctttgggga      120

ggaggaatgt gcccaaggac taaaaaaagg ccatggagcc agaggggcga gggcaacaga      180

cctttcatgg gcaaaccttg gggccctgct gtctagcatg ccccactacg ggtctaggct      240

gcccatgtaa ggaggcaagg cctggggaca cccgagatgc ctggttataa ttaacccaga      300

catgtggctg cccccccccc cccaacacct gctgcctcta aaaataaccc tgtccctggt      360

ggatcccctg catgcgaaga tcttcgaaca aggctgtggg ggactgaggg caggctgtaa      420

caggcttggg ggccagggct tatacgtgcc tgggactccc aaagtattac tgttccatgt      480

tcccggcgaa gggccagctg tcccccgcca gctagactca gcacttagtt taggaaccag      540

tgagcaagtc agcccttggg gcagcccata caaggccatg gggctgggca agctgcacgc      600

ctgggtccgg ggtgggcacg gtgcccgggc aacgagctga aagctcatct gctctcaggg      660

gcccctccct ggggacagcc cctcctggct agtcacaccc tgtaggctcc tctatataac      720

ccaggggcac aggggctgcc ctcattctac caccacctcc acagcacaga cagacactca      780

ggagcagcca gc                                                          792


<210> 5
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Intron

<400> 5
aggtaagttt agtctttttg tcttttattt caggtcccgg atccggtggt ggtgcaaatc       60

aaagaactgc tcctcagtgg atgttgcctt tacttctagg cctgtacgga agtgttactt      120

ctgctctaaa agctgcggaa ttgtaccc                                         148


<210> 6
<211> 4689
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> DYSF F5' Expression Cassette v1

<400> 6
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctctaga gtttaagctt gcatgtctaa      180

gctagaccct tcagattaaa aataactgag gtaagggcct gggtagggga ggtggtgtga      240

gacgctcctg tctctcctct atctgcccat cggccctttg gggaggagga atgtgcccaa      300

ggactaaaaa aaggccatgg agccagaggg gcgagggcaa cagacctttc atgggcaaac      360

cttggggccc tgctgtctag catgccccac tacgggtcta ggctgcccat gtaaggaggc      420

aaggcctggg gacacccgag atgcctggtt ataattaacc cagacatgtg gctgcccccc      480

cccccccaac acctgctgcc tctaaaaata accctgtccc tggtggatcc cctgcatgcg      540

aagatcttcg aacaaggctg tgggggactg agggcaggct gtaacaggct tgggggccag      600

ggcttatacg tgcctgggac tcccaaagta ttactgttcc atgttcccgg cgaagggcca      660

gctgtccccc gccagctaga ctcagcactt agtttaggaa ccagtgagca agtcagccct      720

tggggcagcc catacaaggc catggggctg ggcaagctgc acgcctgggt ccggggtggg      780

cacggtgccc gggcaacgag ctgaaagctc atctgctctc aggggcccct ccctggggac      840

agcccctcct ggctagtcac accctgtagg ctcctctata taacccaggg gcacaggggc      900

tgccctcatt ctaccaccac ctccacagca cagacagaca ctcaggagca gccagcggcg      960

cgcccaggta agtttagtct ttttgtcttt tatttcaggt cccggatccg gtggtggtgc     1020

aaatcaaaga actgctcctc agtggatgtt gcctttactt ctaggcctgt acggaagtgt     1080

tacttctgct ctaaaagctg cggaattgta cccgcggccg cggctagcca ccatgctgag     1140

ggtcttcatc ctctatgccg agaacgtcca cacacccgac accgacatca gcgatgccta     1200

ctgctccgcg gtgtttgcag gggtgaagaa gagaaccaaa gtcatcaaga acagcgtgaa     1260

ccctgtatgg aatgagggat ttgaatggga cctcaagggc atccccctgg accagggctc     1320

tgagcttcat gtggtggtca aagaccatga gacgatgggg aggaacaggt tcctggggga     1380

agccaaggtc ccactccgag aggtcctcgc cacccctagt ctgtccgcca gcttcaatgc     1440

ccccctgctg gacaccaaga agcagcccac aggggcctcg ctggtcctgc aggtgtccta     1500

cacaccgctg cctggagctg tgcccctgtt cccgccccct actcctctgg agccctcccc     1560

gactctgcct gacctggatg tagtggcaga cacaggagga gaggaagaca cagaggacca     1620

gggactcact ggagatgagg cggagccatt cctggatcaa agcggaggcc cgggggctcc     1680

caccacccca aggaaactac cttcacgtcc tccgccccac taccccggga tcaaaagaaa     1740

gcgaagtgcg cctacatcta gaaagctgct gtcagacaaa ccgcaggatt tccagatcag     1800

ggtccaggtg atcgaggggc gccagctgcc gggggtgaac atcaagcctg tggtcaaggt     1860

taccgctgca gggcagacca agcggacgcg gatccacaag ggaaacagcc cactcttcaa     1920

tgagactctt ttcttcaact tgtttgactc tcctggggag ctgtttgatg agcccatctt     1980

tatcacggtg gtagactctc gttctctcag gacagatgct ctcctcgggg agttccggat     2040

ggacgtgggc accatttaca gagagccccg gcacgcctat ctcaggaagt ggctgctgct     2100

ctcagaccct gatgacttct ctgctggggc cagaggctac ctgaaaacaa gcctttgtgt     2160

gctggggcct ggggacgaag cgcctctgga gagaaaagac ccctctgaag acaaggagga     2220

cattgaaagc aacctgctcc ggcccacagg cgtagccctg cgaggagccc acttctgcct     2280

gaaggtcttc cgggccgagg acttgccgca gatggacgat gccgtgatgg acaacgtgaa     2340

acagatcttt ggcttcgaga gtaacaagaa gaacttggtg gacccctttg tggaggtcag     2400

ctttgcgggg aaaatgctgt gcagcaagat cttggagaag acggccaacc ctcagtggaa     2460

ccagaacatc acactgcctg ccatgtttcc ctccatgtgc gaaaaaatga ggattcgtat     2520

catagactgg gaccgcctga ctcacaatga catcgtggct accacctacc tgagtatgtc     2580

gaaaatctct gcccctggag gagaaataga agaggagcct gcaggtgctg tcaagccttc     2640

gaaagcctca gacttggatg actacctggg cttcctcccc acttttgggc cctgctacat     2700

caacctctat ggcagtccca gagagttcac aggcttccca gacccctaca cagagctcaa     2760

cacaggcaag ggggaaggtg tggcttatcg tggccggctt ctgctctccc tggagaccaa     2820

gctggtggag cacagtgaac agaaggtgga ggaccttcct gcggatgaca tcctccgggt     2880

ggagaagtac cttaggaggc gcaagtactc cctgtttgcg gccttctact cagccaccat     2940

gctgcaggat gtggatgatg ccatccagtt tgaggtcagc atcgggaact acgggaacaa     3000

gttcgacatg acctgcctgc cgctggcctc caccactcag tacagccgtg cagtctttga     3060

cgggtgccac tactactacc taccctgggg taacgtgaaa cctgtggtgg tgctgtcatc     3120

ctactgggag gacatcagcc atagaatcga gactcagaac cagctgcttg ggattgctga     3180

ccggctggaa gctggcctgg agcaggtcca cctggccctg aaggcgcagt gctccacgga     3240

ggacgtggac tcgctggtgg ctcagctgac ggatgagctc atcgcaggct gcagccagcc     3300

tctgggtgac atccatgaga caccctctgc cacccacctg gaccagtacc tgtaccagct     3360

gcgcacccat cacctgagcc aaatcactga ggctgccctg gccctgaagc tcggccacag     3420

tgagctccct gcagctctgg agcaggcgga ggactggctc ctgcgtctgc gtgccctggc     3480

agaggagccc cagaacagcc tgccggacat cgtcatctgg atgctgcagg gagacaagcg     3540

tgtggcatac cagcgggtgc ccgcccacca agtcctcttc tcccggcggg gtgccaacta     3600

ctgtggcaag aattgtggga agctacagac aatctttctg aaatatccga tggagaaggt     3660

gcctggcgcc cggatgccag tgcagatacg ggtcaagctg tggtttgggc tctctgtgga     3720

tgagaaggag ttcaaccagt ttgctgaggg gaagctgtct gtctttgctg aaacctatga     3780

gaacgagact aagttggccc ttgttgggaa ctggggcaca acgggcctca cctaccccaa     3840

gttttctgac gtcacgggca agatcaagct acccaaggac agcttccgcc cctcggccgg     3900

ctggacctgg gctggagatt ggttcgtgtg tccggagaag actctgctcc atgacatgga     3960

cgccggtcac ctgagcttcg tggaagaggt gtttgagaac cagacccggc ttcccggagg     4020

ccagtggatc tacatgagtg acaactacac cgatgtgaac ggggagaagg tgcttcccaa     4080

ggatgacatt gagtgcccac tgggctggaa gtgggaagat gaggaatggt ccacagacct     4140

caaccgggct gtcgatgagc aaggctggga gtatagcatc accatccccc cggagcggaa     4200

gccgaagcac tgggtccctg ctgagaagat gtactacaca caccgacggc ggcgctgggt     4260

gcgcctgcgc aggagggatc tcagccaaat ggaagcactg aaaaggcaca ggcaggcgga     4320

ggcggagggc gagggctggg agtacgcctc tctttttggc tggaagttcc acctcgagta     4380

ccgcaagaca gatgccttcc gccgccgccg ctggcgccgt cgcatggagc cactggagaa     4440

gacggggcct gcagctgtgt ttgcccttga gggcggccgc aataaaagat ctttattttc     4500

attagatctg tgtgttggtt ttttgtgtgt ctagagcatg gcgggttaat cattaactac     4560

aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4620

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     4680

cgagcgcgc                                                             4689


<210> 7
<211> 49
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> PolyA Signal

<400> 7
aataaaagat ctttattttc attagatctg tgtgttggtt ttttgtgtg                   49


<210> 8
<211> 4592
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> DYSF F3' Expression Cassette v1

<400> 8
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc catgctctgg      180

tcgactctag agttttcgtc atctggatgc tgcagggaga caagcgtgtg gcataccagc      240

gggtgcccgc ccaccaagtc ctcttctccc ggcggggtgc caactactgt ggcaagaatt      300

gtgggaagct acagacaatc tttctgaaat atccgatgga gaaggtgcct ggcgcccgga      360

tgccagtgca gatacgggtc aagctgtggt ttgggctctc tgtggatgag aaggagttca      420

accagtttgc tgaggggaag ctgtctgtct ttgctgaaac ctatgagaac gagactaagt      480

tggcccttgt tgggaactgg ggcacaacgg gcctcaccta ccccaagttt tctgacgtca      540

cgggcaagat caagctaccc aaggacagct tccgcccctc ggccggctgg acctgggctg      600

gagattggtt cgtgtgtccg gagaagactc tgctccatga catggacgcc ggtcacctga      660

gcttcgtgga agaggtgttt gagaaccaga cccggcttcc cggaggccag tggatctaca      720

tgagtgacaa ctacaccgat gtgaacgggg agaaggtgct tcccaaggat gacattgagt      780

gcccactggg ctggaagtgg gaagatgagg aatggtccac agacctcaac cgggctgtcg      840

atgagcaagg ctgggagtat agcatcacca tccccccgga gcggaagccg aagcactggg      900

tccctgctga gaagatgtac tacacacacc gacggcggcg ctgggtgcgc ctgcgcagga      960

gggatctcag ccaaatggaa gcactgaaaa ggcacaggca ggcggaggcg gagggcgagg     1020

gctgggagta cgcctctctt tttggctgga agttccacct cgagtaccgc aagacagatg     1080

ccttccgccg ccgccgctgg cgccgtcgca tggagccact ggagaagacg gggcctgcag     1140

ctgtgtttgc ccttgagggg gccctgggcg gcgtgatgga tgacaagagt gaagattcca     1200

tgtccgtctc caccttgagc ttcggtgtga acagacccac gatttcctgc atattcgact     1260

atgggaaccg ctaccatcta cgctgctaca tgtaccaggc ccgggacctg gctgcgatgg     1320

acaaggactc tttttctgat ccctatgcca tcgtctcctt cctgcaccag agccagaaga     1380

cggtggtggt gaagaacacc cttaacccca cctgggacca gacgctcatc ttctacgaga     1440

tcgagatctt tggcgagccg gccacagttg ctgagcaacc gcccagcatt gtggtggagc     1500

tgtacgacca tgacacttat ggtgcagacg agtttatggg tcgctgcatc tgtcaaccga     1560

gtctggaacg gatgccacgg ctggcctggt tcccactgac gaggggcagc cagccgtcgg     1620

gggagctgct ggcctctttt gagctcatcc agagagagaa gccggccatc caccatattc     1680

ctggttttga ggtgcaggag acatcaagga tcctggatga gtctgaggac acagacctgc     1740

cctacccacc accccagagg gaggccaaca tctacatggt tcctcagaac atcaagccag     1800

cgctccagcg taccgccatc gagatcctgg catggggcct gcggaacatg aagagttacc     1860

agctggccaa catctcctcc cccagcctcg tggtagagtg tgggggccag acggtgcagt     1920

cctgtgtcat caggaacctc cggaagaacc ccaactttga catctgcacc ctcttcatgg     1980

aagtgatgct gcccagggag gagctctact gcccccccat caccgtcaag gtcatcgata     2040

accgccagtt tggccgccgg cctgtggtgg gccagtgtac catccgctcc ctggagagct     2100

tcctgtgtga cccctactcg gcggagagtc catccccaca gggtggccca gacgatgtga     2160

gcctactcag tcctggggaa gacgtgctca tcgacattga tgacaaggag cccctcatcc     2220

ccatccagga ggaagagttc atcgattggt ggagcaaatt ctttgcctcc ataggggaga     2280

gggaaaagtg cggctcctac ctggagaagg attttgacac cctgaaggtc tatgacacac     2340

agctggagaa tgtggaggcc tttgagggcc tgtctgactt ttgtaacacc ttcaagctgt     2400

accggggcaa gacgcaggag gagacagaag atccatctgt gattggtgaa tttaagggcc     2460

tcttcaaaat ttatcccctc ccagaagacc cagccatccc catgccccca agacagttcc     2520

accagctggc cgcccaggga ccccaggagt gcttggtccg tatctacatt gtccgagcat     2580

ttggcctgca gcccaaggac cccaatggaa agtgtgatcc ttacatcaag atctccatag     2640

ggaagaaatc agtgagtgac caggataact acatcccctg cacgctggag cccgtatttg     2700

gaaagatgtt cgagctgacc tgcactctgc ctctggagaa ggacctaaag atcactctct     2760

atgactatga cctcctctcc aaggacgaaa agatcggtga gacggtcgtc gacctggaga     2820

acaggctgct gtccaagttt ggggctcgct gtggactccc acagacctac tgtgtctctg     2880

gaccgaacca gtggcgggac cagctccgcc cctcccagct cctccacctc ttctgccagc     2940

agcatagagt caaggcacct gtgtaccgga cagaccgtgt aatgtttcag gataaagaat     3000

attccattga agagatagag gctggcagga tcccaaaccc acacctgggc ccagtggagg     3060

agcgtctggc tctgcatgtg cttcagcagc agggcctggt cccggagcac gtggagtcac     3120

ggcccctcta cagccccctg cagccagaca tcgagcaggg gaagctgcag atgtgggtcg     3180

acctatttcc gaaggccctg gggcggcctg gacctccctt caacatcacc ccacggagag     3240

ccagaaggtt tttcctgcgt tgtattatct ggaataccag agatgtgatc ctggatgacc     3300

tgagcctcac gggggagaag atgagcgaca tttatgtgaa aggttggatg attggctttg     3360

aagaacacaa gcaaaagaca gacgtgcatt atcgttccct gggaggtgaa ggcaacttca     3420

actggaggtt cattttcccc ttcgactacc tgccagctga gcaagtctgt accattgcca     3480

agaaggatgc cttctggagg ctggacaaga ctgagagcaa aatcccagca cgagtggtgt     3540

tccagatctg ggacaatgac aagttctcct ttgatgattt tctgggctcc ctgcagctcg     3600

atctcaaccg catgcccaag ccagccaaga cagccaagaa gtgctccttg gaccagctgg     3660

atgatgcttt ccacccagaa tggtttgtgt ccctttttga gcagaaaaca gtgaagggct     3720

ggtggccctg tgtagcagaa gagggtgaga agaaaatact ggcgggcaag ctggaaatga     3780

ccttggagat tgtagcagag agtgagcatg aggagcggcc tgctggccag ggccgggatg     3840

agcccaacat gaaccctaag cttgaggacc caaggcgccc cgacacctcc ttcctgtggt     3900

ttacctcccc atacaagacc atgaagttca tcctgtggcg gcgtttccgg tgggccatca     3960

tcctcttcat catcctcttc atcctgctgc tgttcctggc catcttcatc tacgccttcc     4020

cgaactatgc tgccatgaag ctggtgaagc ccttcagctg aggactctcc tgccctgtag     4080

aaggggccgt ggggtcccct ccagcatggg actggcctgc ctcctccgcc cagctcggcg     4140

agctcctcca gacctcctag gcctgattgt cctgccaggg tgggcagaca gacagatgga     4200

ccggcccaca ctcccagagt tgctaacatg gagctctgag atcaccccac ttccatcatt     4260

tccttctccc ccaacccaac gcttttttgg atcagctcag acatatttca gtataaaaca     4320

gttggaacca caaaaaaaaa aaaaaaaagt cgacgcggcc gcaataaaag atctttattt     4380

tcattagatc tgtgtgttgg ttttttgtgt gtctagagca tggctacgta gataagtagc     4440

atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc     4500

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4560

cccgggcggc ctcagtgagc gagcgagcgc gc                                   4592


<210> 9
<211> 1113
<212> PRT
<213> Homo sapiens

<220>
<223> 5' hDYSF protein fragment

<400> 9
Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160 


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175     


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190         


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220                 


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240 


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255     


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270         


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285             


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300                 


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320 


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335     


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350         


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365             


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380                 


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400 


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415     


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430         


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445             


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460                 


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480 


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro 
                485                 490                 495     


Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu 
            500                 505                 510         


Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser 
        515                 520                 525             


Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr 
    530                 535                 540                 


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu 
545                 550                 555                 560 


Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro 
                565                 570                 575     


Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr 
            580                 585                 590         


Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp 
        595                 600                 605             


Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe 
    610                 615                 620                 


Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala 
625                 630                 635                 640 


Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys 
                645                 650                 655     


Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile 
            660                 665                 670         


Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly 
        675                 680                 685             


Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp 
    690                 695                 700                 


Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys 
705                 710                 715                 720 


Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu 
                725                 730                 735     


Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr 
            740                 745                 750         


Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala 
        755                 760                 765             


Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu 
    770                 775                 780                 


Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly 
785                 790                 795                 800 


Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe 
                805                 810                 815     


Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln 
            820                 825                 830         


Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met 
        835                 840                 845             


Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu 
    850                 855                 860                 


Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu 
865                 870                 875                 880 


Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr 
                885                 890                 895     


Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
            900                 905                 910         


Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly 
        915                 920                 925             


Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala 
    930                 935                 940                 


Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu 
945                 950                 955                 960 


Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val Asn 
                965                 970                 975     


Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly Trp 
            980                 985                 990         


Lys Trp Glu Asp Glu Glu Trp Ser  Thr Asp Leu Asn Arg  Ala Val Asp 
        995                 1000                 1005             


Glu Gln  Gly Trp Glu Tyr Ser  Ile Thr Ile Pro Pro  Glu Arg Lys 
    1010                 1015                 1020             


Pro Lys  His Trp Val Pro Ala  Glu Lys Met Tyr Tyr  Thr His Arg 
    1025                 1030                 1035             


Arg Arg  Arg Trp Val Arg Leu  Arg Arg Arg Asp Leu  Ser Gln Met 
    1040                 1045                 1050             


Glu Ala  Leu Lys Arg His Arg  Gln Ala Glu Ala Glu  Gly Glu Gly 
    1055                 1060                 1065             


Trp Glu  Tyr Ala Ser Leu Phe  Gly Trp Lys Phe His  Leu Glu Tyr 
    1070                 1075                 1080             


Arg Lys  Thr Asp Ala Phe Arg  Arg Arg Arg Trp Arg  Arg Arg Met 
    1085                 1090                 1095             


Glu Pro  Leu Glu Lys Thr Gly  Pro Ala Ala Val Phe  Ala Leu Glu 
    1100                 1105                 1110             


<210> 10
<211> 1287
<212> PRT
<213> Homo sapiens

<220>
<223> 3' hDYSF protein fragment

<400> 10
Val Ile Trp Met Leu Gln Gly Asp Lys Arg Val Ala Tyr Gln Arg Val 
1               5                   10                  15      


Pro Ala His Gln Val Leu Phe Ser Arg Arg Gly Ala Asn Tyr Cys Gly 
            20                  25                  30          


Lys Asn Cys Gly Lys Leu Gln Thr Ile Phe Leu Lys Tyr Pro Met Glu 
        35                  40                  45              


Lys Val Pro Gly Ala Arg Met Pro Val Gln Ile Arg Val Lys Leu Trp 
    50                  55                  60                  


Phe Gly Leu Ser Val Asp Glu Lys Glu Phe Asn Gln Phe Ala Glu Gly 
65                  70                  75                  80  


Lys Leu Ser Val Phe Ala Glu Thr Tyr Glu Asn Glu Thr Lys Leu Ala 
                85                  90                  95      


Leu Val Gly Asn Trp Gly Thr Thr Gly Leu Thr Tyr Pro Lys Phe Ser 
            100                 105                 110         


Asp Val Thr Gly Lys Ile Lys Leu Pro Lys Asp Ser Phe Arg Pro Ser 
        115                 120                 125             


Ala Gly Trp Thr Trp Ala Gly Asp Trp Phe Val Cys Pro Glu Lys Thr 
    130                 135                 140                 


Leu Leu His Asp Met Asp Ala Gly His Leu Ser Phe Val Glu Glu Val 
145                 150                 155                 160 


Phe Glu Asn Gln Thr Arg Leu Pro Gly Gly Gln Trp Ile Tyr Met Ser 
                165                 170                 175     


Asp Asn Tyr Thr Asp Val Asn Gly Glu Lys Val Leu Pro Lys Asp Asp 
            180                 185                 190         


Ile Glu Cys Pro Leu Gly Trp Lys Trp Glu Asp Glu Glu Trp Ser Thr 
        195                 200                 205             


Asp Leu Asn Arg Ala Val Asp Glu Gln Gly Trp Glu Tyr Ser Ile Thr 
    210                 215                 220                 


Ile Pro Pro Glu Arg Lys Pro Lys His Trp Val Pro Ala Glu Lys Met 
225                 230                 235                 240 


Tyr Tyr Thr His Arg Arg Arg Arg Trp Val Arg Leu Arg Arg Arg Asp 
                245                 250                 255     


Leu Ser Gln Met Glu Ala Leu Lys Arg His Arg Gln Ala Glu Ala Glu 
            260                 265                 270         


Gly Glu Gly Trp Glu Tyr Ala Ser Leu Phe Gly Trp Lys Phe His Leu 
        275                 280                 285             


Glu Tyr Arg Lys Thr Asp Ala Phe Arg Arg Arg Arg Trp Arg Arg Arg 
    290                 295                 300                 


Met Glu Pro Leu Glu Lys Thr Gly Pro Ala Ala Val Phe Ala Leu Glu 
305                 310                 315                 320 


Gly Ala Leu Gly Gly Val Met Asp Asp Lys Ser Glu Asp Ser Met Ser 
                325                 330                 335     


Val Ser Thr Leu Ser Phe Gly Val Asn Arg Pro Thr Ile Ser Cys Ile 
            340                 345                 350         


Phe Asp Tyr Gly Asn Arg Tyr His Leu Arg Cys Tyr Met Tyr Gln Ala 
        355                 360                 365             


Arg Asp Leu Ala Ala Met Asp Lys Asp Ser Phe Ser Asp Pro Tyr Ala 
    370                 375                 380                 


Ile Val Ser Phe Leu His Gln Ser Gln Lys Thr Val Val Val Lys Asn 
385                 390                 395                 400 


Thr Leu Asn Pro Thr Trp Asp Gln Thr Leu Ile Phe Tyr Glu Ile Glu 
                405                 410                 415     


Ile Phe Gly Glu Pro Ala Thr Val Ala Glu Gln Pro Pro Ser Ile Val 
            420                 425                 430         


Val Glu Leu Tyr Asp His Asp Thr Tyr Gly Ala Asp Glu Phe Met Gly 
        435                 440                 445             


Arg Cys Ile Cys Gln Pro Ser Leu Glu Arg Met Pro Arg Leu Ala Trp 
    450                 455                 460                 


Phe Pro Leu Thr Arg Gly Ser Gln Pro Ser Gly Glu Leu Leu Ala Ser 
465                 470                 475                 480 


Phe Glu Leu Ile Gln Arg Glu Lys Pro Ala Ile His His Ile Pro Gly 
                485                 490                 495     


Phe Glu Val Gln Glu Thr Ser Arg Ile Leu Asp Glu Ser Glu Asp Thr 
            500                 505                 510         


Asp Leu Pro Tyr Pro Pro Pro Gln Arg Glu Ala Asn Ile Tyr Met Val 
        515                 520                 525             


Pro Gln Asn Ile Lys Pro Ala Leu Gln Arg Thr Ala Ile Glu Ile Leu 
    530                 535                 540                 


Ala Trp Gly Leu Arg Asn Met Lys Ser Tyr Gln Leu Ala Asn Ile Ser 
545                 550                 555                 560 


Ser Pro Ser Leu Val Val Glu Cys Gly Gly Gln Thr Val Gln Ser Cys 
                565                 570                 575     


Val Ile Arg Asn Leu Arg Lys Asn Pro Asn Phe Asp Ile Cys Thr Leu 
            580                 585                 590         


Phe Met Glu Val Met Leu Pro Arg Glu Glu Leu Tyr Cys Pro Pro Ile 
        595                 600                 605             


Thr Val Lys Val Ile Asp Asn Arg Gln Phe Gly Arg Arg Pro Val Val 
    610                 615                 620                 


Gly Gln Cys Thr Ile Arg Ser Leu Glu Ser Phe Leu Cys Asp Pro Tyr 
625                 630                 635                 640 


Ser Ala Glu Ser Pro Ser Pro Gln Gly Gly Pro Asp Asp Val Ser Leu 
                645                 650                 655     


Leu Ser Pro Gly Glu Asp Val Leu Ile Asp Ile Asp Asp Lys Glu Pro 
            660                 665                 670         


Leu Ile Pro Ile Gln Glu Glu Glu Phe Ile Asp Trp Trp Ser Lys Phe 
        675                 680                 685             


Phe Ala Ser Ile Gly Glu Arg Glu Lys Cys Gly Ser Tyr Leu Glu Lys 
    690                 695                 700                 


Asp Phe Asp Thr Leu Lys Val Tyr Asp Thr Gln Leu Glu Asn Val Glu 
705                 710                 715                 720 


Ala Phe Glu Gly Leu Ser Asp Phe Cys Asn Thr Phe Lys Leu Tyr Arg 
                725                 730                 735     


Gly Lys Thr Gln Glu Glu Thr Glu Asp Pro Ser Val Ile Gly Glu Phe 
            740                 745                 750         


Lys Gly Leu Phe Lys Ile Tyr Pro Leu Pro Glu Asp Pro Ala Ile Pro 
        755                 760                 765             


Met Pro Pro Arg Gln Phe His Gln Leu Ala Ala Gln Gly Pro Gln Glu 
    770                 775                 780                 


Cys Leu Val Arg Ile Tyr Ile Val Arg Ala Phe Gly Leu Gln Pro Lys 
785                 790                 795                 800 


Asp Pro Asn Gly Lys Cys Asp Pro Tyr Ile Lys Ile Ser Ile Gly Lys 
                805                 810                 815     


Lys Ser Val Ser Asp Gln Asp Asn Tyr Ile Pro Cys Thr Leu Glu Pro 
            820                 825                 830         


Val Phe Gly Lys Met Phe Glu Leu Thr Cys Thr Leu Pro Leu Glu Lys 
        835                 840                 845             


Asp Leu Lys Ile Thr Leu Tyr Asp Tyr Asp Leu Leu Ser Lys Asp Glu 
    850                 855                 860                 


Lys Ile Gly Glu Thr Val Val Asp Leu Glu Asn Arg Leu Leu Ser Lys 
865                 870                 875                 880 


Phe Gly Ala Arg Cys Gly Leu Pro Gln Thr Tyr Cys Val Ser Gly Pro 
                885                 890                 895     


Asn Gln Trp Arg Asp Gln Leu Arg Pro Ser Gln Leu Leu His Leu Phe 
            900                 905                 910         


Cys Gln Gln His Arg Val Lys Ala Pro Val Tyr Arg Thr Asp Arg Val 
        915                 920                 925             


Met Phe Gln Asp Lys Glu Tyr Ser Ile Glu Glu Ile Glu Ala Gly Arg 
    930                 935                 940                 


Ile Pro Asn Pro His Leu Gly Pro Val Glu Glu Arg Leu Ala Leu His 
945                 950                 955                 960 


Val Leu Gln Gln Gln Gly Leu Val Pro Glu His Val Glu Ser Arg Pro 
                965                 970                 975     


Leu Tyr Ser Pro Leu Gln Pro Asp Ile Glu Gln Gly Lys Leu Gln Met 
            980                 985                 990         


Trp Val Asp Leu Phe Pro Lys Ala  Leu Gly Arg Pro Gly  Pro Pro Phe 
        995                 1000                 1005             


Asn Ile  Thr Pro Arg Arg Ala  Arg Arg Phe Phe Leu  Arg Cys Ile 
    1010                 1015                 1020             


Ile Trp  Asn Thr Arg Asp Val  Ile Leu Asp Asp Leu  Ser Leu Thr 
    1025                 1030                 1035             


Gly Glu  Lys Met Ser Asp Ile  Tyr Val Lys Gly Trp  Met Ile Gly 
    1040                 1045                 1050             


Phe Glu  Glu His Lys Gln Lys  Thr Asp Val His Tyr  Arg Ser Leu 
    1055                 1060                 1065             


Gly Gly  Glu Gly Asn Phe Asn  Trp Arg Phe Ile Phe  Pro Phe Asp 
    1070                 1075                 1080             


Tyr Leu  Pro Ala Glu Gln Val  Cys Thr Ile Ala Lys  Lys Asp Ala 
    1085                 1090                 1095             


Phe Trp  Arg Leu Asp Lys Thr  Glu Ser Lys Ile Pro  Ala Arg Val 
    1100                 1105                 1110             


Val Phe  Gln Ile Trp Asp Asn  Asp Lys Phe Ser Phe  Asp Asp Phe 
    1115                 1120                 1125             


Leu Gly  Ser Leu Gln Leu Asp  Leu Asn Arg Met Pro  Lys Pro Ala 
    1130                 1135                 1140             


Lys Thr  Ala Lys Lys Cys Ser  Leu Asp Gln Leu Asp  Asp Ala Phe 
    1145                 1150                 1155             


His Pro  Glu Trp Phe Val Ser  Leu Phe Glu Gln Lys  Thr Val Lys 
    1160                 1165                 1170             


Gly Trp  Trp Pro Cys Val Ala  Glu Glu Gly Glu Lys  Lys Ile Leu 
    1175                 1180                 1185             


Ala Gly  Lys Leu Glu Met Thr  Leu Glu Ile Val Ala  Glu Ser Glu 
    1190                 1195                 1200             


His Glu  Glu Arg Pro Ala Gly  Gln Gly Arg Asp Glu  Pro Asn Met 
    1205                 1210                 1215             


Asn Pro  Lys Leu Glu Asp Pro  Arg Arg Pro Asp Thr  Ser Phe Leu 
    1220                 1225                 1230             


Trp Phe  Thr Ser Pro Tyr Lys  Thr Met Lys Phe Ile  Leu Trp Arg 
    1235                 1240                 1245             


Arg Phe  Arg Trp Ala Ile Ile  Leu Phe Ile Ile Leu  Phe Ile Leu 
    1250                 1255                 1260             


Leu Leu  Phe Leu Ala Ile Phe  Ile Tyr Ala Phe Pro  Asn Tyr Ala 
    1265                 1270                 1275             


Ala Met  Lys Leu Val Lys Pro  Phe Ser 
    1280                 1285         


<210> 11
<211> 6914
<212> DNA
<213> Homo sapiens

<220>
<223> hDYSF DNA full length

<400> 11
gcggccgccg cccagccagg tgcaaaatgc cgtgtcattg ggagactccg cagccggagc       60

attagattac agctcgacgg agctcgggaa gggcggcggg ggtggaagat gagcagaagc      120

ccctgttctc ggaacgccgg ctgacaagcg gggtgagcgc agccggggcg gggacccagc      180

ctagcccact ggagcagccg ggggtggccc gttccccttt aagagcaact gctctaagcc      240

aggagccaga gattcgagcc ggcctcgccc agccagccct ctccagcgag gggacccaca      300

agcggcgcct cggccctccc gacctttccg agccctcttt gcgccctggg cgcacggggc      360

cctacacgcg ccaagcatgc tgagggtctt catcctctat gccgagaacg tccacacacc      420

cgacaccgac atcagcgatg cctactgctc cgcggtgttt gcaggggtga agaagagaac      480

caaagtcatc aagaacagcg tgaaccctgt atggaatgag ggatttgaat gggacctcaa      540

gggcatcccc ctggaccagg gctctgagct tcatgtggtg gtcaaagacc atgagacgat      600

ggggaggaac aggttcctgg gggaagccaa ggtcccactc cgagaggtcc tcgccacccc      660

tagtctgtcc gccagcttca atgcccccct gctggacacc aagaagcagc ccacaggggc      720

ctcgctggtc ctgcaggtgt cctacacacc gctgcctgga gctgtgcccc tgttcccgcc      780

ccctactcct ctggagccct ccccgactct gcctgacctg gatgtagtgg cagacacagg      840

aggagaggaa gacacagagg accagggact cactggagat gaggcggagc cattcctgga      900

tcaaagcgga ggcccggggg ctcccaccac cccaaggaaa ctaccttcac gtcctccgcc      960

ccactacccc gggatcaaaa gaaagcgaag tgcgcctaca tctagaaagc tgctgtcaga     1020

caaaccgcag gatttccaga tcagggtcca ggtgatcgag gggcgccagc tgccgggggt     1080

gaacatcaag cctgtggtca aggttaccgc tgcagggcag accaagcgga cgcggatcca     1140

caagggaaac agcccactct tcaatgagac tcttttcttc aacttgtttg actctcctgg     1200

ggagctgttt gatgagccca tctttatcac ggtggtagac tctcgttctc tcaggacaga     1260

tgctctcctc ggggagttcc ggatggacgt gggcaccatt tacagagagc cccggcacgc     1320

ctatctcagg aagtggctgc tgctctcaga ccctgatgac ttctctgctg gggccagagg     1380

ctacctgaaa acaagccttt gtgtgctggg gcctggggac gaagcgcctc tggagagaaa     1440

agacccctct gaagacaagg aggacattga aagcaacctg ctccggccca caggcgtagc     1500

cctgcgagga gcccacttct gcctgaaggt cttccgggcc gaggacttgc cgcagatgga     1560

cgatgccgtg atggacaacg tgaaacagat ctttggcttc gagagtaaca agaagaactt     1620

ggtggacccc tttgtggagg tcagctttgc ggggaaaatg ctgtgcagca agatcttgga     1680

gaagacggcc aaccctcagt ggaaccagaa catcacactg cctgccatgt ttccctccat     1740

gtgcgaaaaa atgaggattc gtatcataga ctgggaccgc ctgactcaca atgacatcgt     1800

ggctaccacc tacctgagta tgtcgaaaat ctctgcccct ggaggagaaa tagaagagga     1860

gcctgcaggt gctgtcaagc cttcgaaagc ctcagacttg gatgactacc tgggcttcct     1920

ccccactttt gggccctgct acatcaacct ctatggcagt cccagagagt tcacaggctt     1980

cccagacccc tacacagagc tcaacacagg caagggggaa ggtgtggctt atcgtggccg     2040

gcttctgctc tccctggaga ccaagctggt ggagcacagt gaacagaagg tggaggacct     2100

tcctgcggat gacatcctcc gggtggagaa gtaccttagg aggcgcaagt actccctgtt     2160

tgcggccttc tactcagcca ccatgctgca ggatgtggat gatgccatcc agtttgaggt     2220

cagcatcggg aactacggga acaagttcga catgacctgc ctgccgctgg cctccaccac     2280

tcagtacagc cgtgcagtct ttgacgggtg ccactactac tacctaccct ggggtaacgt     2340

gaaacctgtg gtggtgctgt catcctactg ggaggacatc agccatagaa tcgagactca     2400

gaaccagctg cttgggattg ctgaccggct ggaagctggc ctggagcagg tccacctggc     2460

cctgaaggcg cagtgctcca cggaggacgt ggactcgctg gtggctcagc tgacggatga     2520

gctcatcgca ggctgcagcc agcctctggg tgacatccat gagacaccct ctgccaccca     2580

cctggaccag tacctgtacc agctgcgcac ccatcacctg agccaaatca ctgaggctgc     2640

cctggccctg aagctcggcc acagtgagct ccctgcagct ctggagcagg cggaggactg     2700

gctcctgcgt ctgcgtgccc tggcagagga gccccagaac agcctgccgg acatcgtcat     2760

ctggatgctg cagggagaca agcgtgtggc ataccagcgg gtgcccgccc accaagtcct     2820

cttctcccgg cggggtgcca actactgtgg caagaattgt gggaagctac agacaatctt     2880

tctgaaatat ccgatggaga aggtgcctgg cgcccggatg ccagtgcaga tacgggtcaa     2940

gctgtggttt gggctctcag tggatgagaa ggagttcaac cagtttgctg aggggaagct     3000

gtctgtcttt gctgaaacct atgagaacga gactaagttg gcccttgttg ggaactgggg     3060

cacaacgggc ctcacctacc ccaagttttc tgacgtcacg ggcaagatca agctacccaa     3120

ggacagcttc cgcccctcgg ccggctggac ctgggctgga gattggttcg tgtgtccgga     3180

gaagactctg ctccatgaca tggacgccgg tcacctgagc ttcgtggaag aggtgtttga     3240

gaaccagacc cggcttcccg gaggccagtg gatctacatg agtgacaact acaccgatgt     3300

gaacggggag aaggtgcttc ccaaggatga cattgagtgc ccactgggct ggaagtggga     3360

agatgaggaa tggtccacag acctcaaccg ggctgtcgat gagcaaggct gggagtatag     3420

catcaccatc cccccggagc ggaagccgaa gcactgggtc cctgctgaga agatgtacta     3480

cacacaccga cggcggcgct gggtgcgcct gcgcaggagg gatctcagcc aaatggaagc     3540

actgaaaagg cacaggcagg cggaggcgga gggcgagggc tgggagtacg cctctctttt     3600

tggctggaag ttccacctcg agtaccgcaa gacagatgcc ttccgccgcc gccgctggcg     3660

ccgtcgcatg gagccactgg agaagacggg gcctgcagct gtgtttgccc ttgagggggc     3720

cctgggcggc gtgatggatg acaagagtga agattccatg tccgtctcca ccttgagctt     3780

cggtgtgaac agacccacga tttcctgcat attcgactat gggaaccgct accatctacg     3840

ctgctacatg taccaggccc gggacctggc tgcgatggac aaggactctt tttctgatcc     3900

ctatgccatc gtctccttcc tgcaccagag ccagaagacg gtggtggtga agaacaccct     3960

taaccccacc tgggaccaga cgctcatctt ctacgagatc gagatctttg gcgagccggc     4020

cacagttgct gagcaaccgc ccagcattgt ggtggagctg tacgaccatg acacttatgg     4080

tgcagacgag tttatgggtc gctgcatctg tcaaccgagt ctggaacgga tgccacggct     4140

ggcctggttc ccactgacga ggggcagcca gccgtcgggg gagctgctgg cctcttttga     4200

gctcatccag agagagaagc cggccatcca ccatattcct ggttttgagg tgcaggagac     4260

atcaaggatc ctggatgagt ctgaggacac agacctgccc tacccaccac cccagaggga     4320

ggccaacatc tacatggttc ctcagaacat caagccagcg ctccagcgta ccgccatcga     4380

gatcctggca tggggcctgc ggaacatgaa gagttaccag ctggccaaca tctcctcccc     4440

cagcctcgtg gtagagtgtg ggggccagac ggtgcagtcc tgtgtcatca ggaacctccg     4500

gaagaacccc aactttgaca tctgcaccct cttcatggaa gtgatgctgc ccagggagga     4560

gctctactgc ccccccatca ccgtcaaggt catcgataac cgccagtttg gccgccggcc     4620

tgtggtgggc cagtgtacca tccgctccct ggagagcttc ctgtgtgacc cctactcggc     4680

ggagagtcca tccccacagg gtggcccaga cgatgtgagc ctactcagtc ctggggaaga     4740

cgtgctcatc gacattgatg acaaggagcc cctcatcccc atccaggagg aagagttcat     4800

cgattggtgg agcaaattct ttgcctccat aggggagagg gaaaagtgcg gctcctacct     4860

ggagaaggat tttgacaccc tgaaggtcta tgacacacag ctggagaatg tggaggcctt     4920

tgagggcctg tctgactttt gtaacacctt caagctgtac cggggcaaga cgcaggagga     4980

gacagaagat ccatctgtga ttggtgaatt taagggcctc ttcaaaattt atcccctccc     5040

agaagaccca gccatcccca tgcccccaag acagttccac cagctggccg cccagggacc     5100

ccaggagtgc ttggtccgta tctacattgt ccgagcattt ggcctgcagc ccaaggaccc     5160

caatggaaag tgtgatcctt acatcaagat ctccataggg aagaaatcag tgagtgacca     5220

ggataactac atcccctgca cgctggagcc cgtatttgga aagatgttcg agctgacctg     5280

cactctgcct ctggagaagg acctaaagat cactctctat gactatgacc tcctctccaa     5340

ggacgaaaag atcggtgaga cggtcgtcga cctggagaac aggctgctgt ccaagtttgg     5400

ggctcgctgt ggactcccac agacctactg tgtctctgga ccgaaccagt ggcgggacca     5460

gctccgcccc tcccagctcc tccacctctt ctgccagcag catagagtca aggcacctgt     5520

gtaccggaca gaccgtgtaa tgtttcagga taaagaatat tccattgaag agatagaggc     5580

tggcaggatc ccaaacccac acctgggccc agtggaggag cgtctggctc tgcatgtgct     5640

tcagcagcag ggcctggtcc cggagcacgt ggagtcacgg cccctctaca gccccctgca     5700

gccagacatc gagcagggga agctgcagat gtgggtcgac ctatttccga aggccctggg     5760

gcggcctgga cctcccttca acatcacccc acggagagcc agaaggtttt tcctgcgttg     5820

tattatctgg aataccagag atgtgatcct ggatgacctg agcctcacgg gggagaagat     5880

gagcgacatt tatgtgaaag gttggatgat tggctttgaa gaacacaagc aaaagacaga     5940

cgtgcattat cgttccctgg gaggtgaagg caacttcaac tggaggttca ttttcccctt     6000

cgactacctg ccagctgagc aagtctgtac cattgccaag aaggatgcct tctggaggct     6060

ggacaagact gagagcaaaa tcccagcacg agtggtgttc cagatctggg acaatgacaa     6120

gttctccttt gatgattttc tgggctccct gcagctcgat ctcaaccgca tgcccaagcc     6180

agccaagaca gccaagaagt gctccttgga ccagctggat gatgctttcc acccagaatg     6240

gtttgtgtcc ctttttgagc agaaaacagt gaagggctgg tggccctgtg tagcagaaga     6300

gggtgagaag aaaatactgg cgggcaagct ggaaatgacc ttggagattg tagcagagag     6360

tgagcatgag gagcggcctg ctggccaggg ccgggatgag cccaacatga accctaagct     6420

tgaggaccca aggcgccccg acacctcctt cctgtggttt acctccccat acaagaccat     6480

gaagttcatc ctgtggcggc gtttccggtg ggccatcatc ctcttcatca tcctcttcat     6540

cctgctgctg ttcctggcca tcttcatcta cgccttcccg aactatgctg ccatgaagct     6600

ggtgaagccc ttcagctgag gactctcctg ccctgtagaa ggggccgtgg ggtcccctcc     6660

agcatgggac tggcctgcct cctccgccca gctcggcgag ctcctccaga cctcctaggc     6720

ctgattgtcc tgccagggtg ggcagacaga cagatggacc ggcccacact cccagagttg     6780

ctaacatgga gctctgagat caccccactt ccatcatttc cttctccccc aacccaacgc     6840

ttttttggat cagctcagac atatttcagt ataaaacagt tggaaccaca aaaaaaaaaa     6900

aaaaaaaaaa aaaa                                                       6914


<210> 12
<211> 2080
<212> PRT
<213> Homo sapiens

<220>
<223> hDYSF protein full length

<400> 12
Met Leu Arg Val Phe Ile Leu Tyr Ala Glu Asn Val His Thr Pro Asp 
1               5                   10                  15      


Thr Asp Ile Ser Asp Ala Tyr Cys Ser Ala Val Phe Ala Gly Val Lys 
            20                  25                  30          


Lys Arg Thr Lys Val Ile Lys Asn Ser Val Asn Pro Val Trp Asn Glu 
        35                  40                  45              


Gly Phe Glu Trp Asp Leu Lys Gly Ile Pro Leu Asp Gln Gly Ser Glu 
    50                  55                  60                  


Leu His Val Val Val Lys Asp His Glu Thr Met Gly Arg Asn Arg Phe 
65                  70                  75                  80  


Leu Gly Glu Ala Lys Val Pro Leu Arg Glu Val Leu Ala Thr Pro Ser 
                85                  90                  95      


Leu Ser Ala Ser Phe Asn Ala Pro Leu Leu Asp Thr Lys Lys Gln Pro 
            100                 105                 110         


Thr Gly Ala Ser Leu Val Leu Gln Val Ser Tyr Thr Pro Leu Pro Gly 
        115                 120                 125             


Ala Val Pro Leu Phe Pro Pro Pro Thr Pro Leu Glu Pro Ser Pro Thr 
    130                 135                 140                 


Leu Pro Asp Leu Asp Val Val Ala Asp Thr Gly Gly Glu Glu Asp Thr 
145                 150                 155                 160 


Glu Asp Gln Gly Leu Thr Gly Asp Glu Ala Glu Pro Phe Leu Asp Gln 
                165                 170                 175     


Ser Gly Gly Pro Gly Ala Pro Thr Thr Pro Arg Lys Leu Pro Ser Arg 
            180                 185                 190         


Pro Pro Pro His Tyr Pro Gly Ile Lys Arg Lys Arg Ser Ala Pro Thr 
        195                 200                 205             


Ser Arg Lys Leu Leu Ser Asp Lys Pro Gln Asp Phe Gln Ile Arg Val 
    210                 215                 220                 


Gln Val Ile Glu Gly Arg Gln Leu Pro Gly Val Asn Ile Lys Pro Val 
225                 230                 235                 240 


Val Lys Val Thr Ala Ala Gly Gln Thr Lys Arg Thr Arg Ile His Lys 
                245                 250                 255     


Gly Asn Ser Pro Leu Phe Asn Glu Thr Leu Phe Phe Asn Leu Phe Asp 
            260                 265                 270         


Ser Pro Gly Glu Leu Phe Asp Glu Pro Ile Phe Ile Thr Val Val Asp 
        275                 280                 285             


Ser Arg Ser Leu Arg Thr Asp Ala Leu Leu Gly Glu Phe Arg Met Asp 
    290                 295                 300                 


Val Gly Thr Ile Tyr Arg Glu Pro Arg His Ala Tyr Leu Arg Lys Trp 
305                 310                 315                 320 


Leu Leu Leu Ser Asp Pro Asp Asp Phe Ser Ala Gly Ala Arg Gly Tyr 
                325                 330                 335     


Leu Lys Thr Ser Leu Cys Val Leu Gly Pro Gly Asp Glu Ala Pro Leu 
            340                 345                 350         


Glu Arg Lys Asp Pro Ser Glu Asp Lys Glu Asp Ile Glu Ser Asn Leu 
        355                 360                 365             


Leu Arg Pro Thr Gly Val Ala Leu Arg Gly Ala His Phe Cys Leu Lys 
    370                 375                 380                 


Val Phe Arg Ala Glu Asp Leu Pro Gln Met Asp Asp Ala Val Met Asp 
385                 390                 395                 400 


Asn Val Lys Gln Ile Phe Gly Phe Glu Ser Asn Lys Lys Asn Leu Val 
                405                 410                 415     


Asp Pro Phe Val Glu Val Ser Phe Ala Gly Lys Met Leu Cys Ser Lys 
            420                 425                 430         


Ile Leu Glu Lys Thr Ala Asn Pro Gln Trp Asn Gln Asn Ile Thr Leu 
        435                 440                 445             


Pro Ala Met Phe Pro Ser Met Cys Glu Lys Met Arg Ile Arg Ile Ile 
    450                 455                 460                 


Asp Trp Asp Arg Leu Thr His Asn Asp Ile Val Ala Thr Thr Tyr Leu 
465                 470                 475                 480 


Ser Met Ser Lys Ile Ser Ala Pro Gly Gly Glu Ile Glu Glu Glu Pro 
                485                 490                 495     


Ala Gly Ala Val Lys Pro Ser Lys Ala Ser Asp Leu Asp Asp Tyr Leu 
            500                 505                 510         


Gly Phe Leu Pro Thr Phe Gly Pro Cys Tyr Ile Asn Leu Tyr Gly Ser 
        515                 520                 525             


Pro Arg Glu Phe Thr Gly Phe Pro Asp Pro Tyr Thr Glu Leu Asn Thr 
    530                 535                 540                 


Gly Lys Gly Glu Gly Val Ala Tyr Arg Gly Arg Leu Leu Leu Ser Leu 
545                 550                 555                 560 


Glu Thr Lys Leu Val Glu His Ser Glu Gln Lys Val Glu Asp Leu Pro 
                565                 570                 575     


Ala Asp Asp Ile Leu Arg Val Glu Lys Tyr Leu Arg Arg Arg Lys Tyr 
            580                 585                 590         


Ser Leu Phe Ala Ala Phe Tyr Ser Ala Thr Met Leu Gln Asp Val Asp 
        595                 600                 605             


Asp Ala Ile Gln Phe Glu Val Ser Ile Gly Asn Tyr Gly Asn Lys Phe 
    610                 615                 620                 


Asp Met Thr Cys Leu Pro Leu Ala Ser Thr Thr Gln Tyr Ser Arg Ala 
625                 630                 635                 640 


Val Phe Asp Gly Cys His Tyr Tyr Tyr Leu Pro Trp Gly Asn Val Lys 
                645                 650                 655     


Pro Val Val Val Leu Ser Ser Tyr Trp Glu Asp Ile Ser His Arg Ile 
            660                 665                 670         


Glu Thr Gln Asn Gln Leu Leu Gly Ile Ala Asp Arg Leu Glu Ala Gly 
        675                 680                 685             


Leu Glu Gln Val His Leu Ala Leu Lys Ala Gln Cys Ser Thr Glu Asp 
    690                 695                 700                 


Val Asp Ser Leu Val Ala Gln Leu Thr Asp Glu Leu Ile Ala Gly Cys 
705                 710                 715                 720 


Ser Gln Pro Leu Gly Asp Ile His Glu Thr Pro Ser Ala Thr His Leu 
                725                 730                 735     


Asp Gln Tyr Leu Tyr Gln Leu Arg Thr His His Leu Ser Gln Ile Thr 
            740                 745                 750         


Glu Ala Ala Leu Ala Leu Lys Leu Gly His Ser Glu Leu Pro Ala Ala 
        755                 760                 765             


Leu Glu Gln Ala Glu Asp Trp Leu Leu Arg Leu Arg Ala Leu Ala Glu 
    770                 775                 780                 


Glu Pro Gln Asn Ser Leu Pro Asp Ile Val Ile Trp Met Leu Gln Gly 
785                 790                 795                 800 


Asp Lys Arg Val Ala Tyr Gln Arg Val Pro Ala His Gln Val Leu Phe 
                805                 810                 815     


Ser Arg Arg Gly Ala Asn Tyr Cys Gly Lys Asn Cys Gly Lys Leu Gln 
            820                 825                 830         


Thr Ile Phe Leu Lys Tyr Pro Met Glu Lys Val Pro Gly Ala Arg Met 
        835                 840                 845             


Pro Val Gln Ile Arg Val Lys Leu Trp Phe Gly Leu Ser Val Asp Glu 
    850                 855                 860                 


Lys Glu Phe Asn Gln Phe Ala Glu Gly Lys Leu Ser Val Phe Ala Glu 
865                 870                 875                 880 


Thr Tyr Glu Asn Glu Thr Lys Leu Ala Leu Val Gly Asn Trp Gly Thr 
                885                 890                 895     


Thr Gly Leu Thr Tyr Pro Lys Phe Ser Asp Val Thr Gly Lys Ile Lys 
            900                 905                 910         


Leu Pro Lys Asp Ser Phe Arg Pro Ser Ala Gly Trp Thr Trp Ala Gly 
        915                 920                 925             


Asp Trp Phe Val Cys Pro Glu Lys Thr Leu Leu His Asp Met Asp Ala 
    930                 935                 940                 


Gly His Leu Ser Phe Val Glu Glu Val Phe Glu Asn Gln Thr Arg Leu 
945                 950                 955                 960 


Pro Gly Gly Gln Trp Ile Tyr Met Ser Asp Asn Tyr Thr Asp Val Asn 
                965                 970                 975     


Gly Glu Lys Val Leu Pro Lys Asp Asp Ile Glu Cys Pro Leu Gly Trp 
            980                 985                 990         


Lys Trp Glu Asp Glu Glu Trp Ser  Thr Asp Leu Asn Arg  Ala Val Asp 
        995                 1000                 1005             


Glu Gln  Gly Trp Glu Tyr Ser  Ile Thr Ile Pro Pro  Glu Arg Lys 
    1010                 1015                 1020             


Pro Lys  His Trp Val Pro Ala  Glu Lys Met Tyr Tyr  Thr His Arg 
    1025                 1030                 1035             


Arg Arg  Arg Trp Val Arg Leu  Arg Arg Arg Asp Leu  Ser Gln Met 
    1040                 1045                 1050             


Glu Ala  Leu Lys Arg His Arg  Gln Ala Glu Ala Glu  Gly Glu Gly 
    1055                 1060                 1065             


Trp Glu  Tyr Ala Ser Leu Phe  Gly Trp Lys Phe His  Leu Glu Tyr 
    1070                 1075                 1080             


Arg Lys  Thr Asp Ala Phe Arg  Arg Arg Arg Trp Arg  Arg Arg Met 
    1085                 1090                 1095             


Glu Pro  Leu Glu Lys Thr Gly  Pro Ala Ala Val Phe  Ala Leu Glu 
    1100                 1105                 1110             


Gly Ala  Leu Gly Gly Val Met  Asp Asp Lys Ser Glu  Asp Ser Met 
    1115                 1120                 1125             


Ser Val  Ser Thr Leu Ser Phe  Gly Val Asn Arg Pro  Thr Ile Ser 
    1130                 1135                 1140             


Cys Ile  Phe Asp Tyr Gly Asn  Arg Tyr His Leu Arg  Cys Tyr Met 
    1145                 1150                 1155             


Tyr Gln  Ala Arg Asp Leu Ala  Ala Met Asp Lys Asp  Ser Phe Ser 
    1160                 1165                 1170             


Asp Pro  Tyr Ala Ile Val Ser  Phe Leu His Gln Ser  Gln Lys Thr 
    1175                 1180                 1185             


Val Val  Val Lys Asn Thr Leu  Asn Pro Thr Trp Asp  Gln Thr Leu 
    1190                 1195                 1200             


Ile Phe  Tyr Glu Ile Glu Ile  Phe Gly Glu Pro Ala  Thr Val Ala 
    1205                 1210                 1215             


Glu Gln  Pro Pro Ser Ile Val  Val Glu Leu Tyr Asp  His Asp Thr 
    1220                 1225                 1230             


Tyr Gly  Ala Asp Glu Phe Met  Gly Arg Cys Ile Cys  Gln Pro Ser 
    1235                 1240                 1245             


Leu Glu  Arg Met Pro Arg Leu  Ala Trp Phe Pro Leu  Thr Arg Gly 
    1250                 1255                 1260             


Ser Gln  Pro Ser Gly Glu Leu  Leu Ala Ser Phe Glu  Leu Ile Gln 
    1265                 1270                 1275             


Arg Glu  Lys Pro Ala Ile His  His Ile Pro Gly Phe  Glu Val Gln 
    1280                 1285                 1290             


Glu Thr  Ser Arg Ile Leu Asp  Glu Ser Glu Asp Thr  Asp Leu Pro 
    1295                 1300                 1305             


Tyr Pro  Pro Pro Gln Arg Glu  Ala Asn Ile Tyr Met  Val Pro Gln 
    1310                 1315                 1320             


Asn Ile  Lys Pro Ala Leu Gln  Arg Thr Ala Ile Glu  Ile Leu Ala 
    1325                 1330                 1335             


Trp Gly  Leu Arg Asn Met Lys  Ser Tyr Gln Leu Ala  Asn Ile Ser 
    1340                 1345                 1350             


Ser Pro  Ser Leu Val Val Glu  Cys Gly Gly Gln Thr  Val Gln Ser 
    1355                 1360                 1365             


Cys Val  Ile Arg Asn Leu Arg  Lys Asn Pro Asn Phe  Asp Ile Cys 
    1370                 1375                 1380             


Thr Leu  Phe Met Glu Val Met  Leu Pro Arg Glu Glu  Leu Tyr Cys 
    1385                 1390                 1395             


Pro Pro  Ile Thr Val Lys Val  Ile Asp Asn Arg Gln  Phe Gly Arg 
    1400                 1405                 1410             


Arg Pro  Val Val Gly Gln Cys  Thr Ile Arg Ser Leu  Glu Ser Phe 
    1415                 1420                 1425             


Leu Cys  Asp Pro Tyr Ser Ala  Glu Ser Pro Ser Pro  Gln Gly Gly 
    1430                 1435                 1440             


Pro Asp  Asp Val Ser Leu Leu  Ser Pro Gly Glu Asp  Val Leu Ile 
    1445                 1450                 1455             


Asp Ile  Asp Asp Lys Glu Pro  Leu Ile Pro Ile Gln  Glu Glu Glu 
    1460                 1465                 1470             


Phe Ile  Asp Trp Trp Ser Lys  Phe Phe Ala Ser Ile  Gly Glu Arg 
    1475                 1480                 1485             


Glu Lys  Cys Gly Ser Tyr Leu  Glu Lys Asp Phe Asp  Thr Leu Lys 
    1490                 1495                 1500             


Val Tyr  Asp Thr Gln Leu Glu  Asn Val Glu Ala Phe  Glu Gly Leu 
    1505                 1510                 1515             


Ser Asp  Phe Cys Asn Thr Phe  Lys Leu Tyr Arg Gly  Lys Thr Gln 
    1520                 1525                 1530             


Glu Glu  Thr Glu Asp Pro Ser  Val Ile Gly Glu Phe  Lys Gly Leu 
    1535                 1540                 1545             


Phe Lys  Ile Tyr Pro Leu Pro  Glu Asp Pro Ala Ile  Pro Met Pro 
    1550                 1555                 1560             


Pro Arg  Gln Phe His Gln Leu  Ala Ala Gln Gly Pro  Gln Glu Cys 
    1565                 1570                 1575             


Leu Val  Arg Ile Tyr Ile Val  Arg Ala Phe Gly Leu  Gln Pro Lys 
    1580                 1585                 1590             


Asp Pro  Asn Gly Lys Cys Asp  Pro Tyr Ile Lys Ile  Ser Ile Gly 
    1595                 1600                 1605             


Lys Lys  Ser Val Ser Asp Gln  Asp Asn Tyr Ile Pro  Cys Thr Leu 
    1610                 1615                 1620             


Glu Pro  Val Phe Gly Lys Met  Phe Glu Leu Thr Cys  Thr Leu Pro 
    1625                 1630                 1635             


Leu Glu  Lys Asp Leu Lys Ile  Thr Leu Tyr Asp Tyr  Asp Leu Leu 
    1640                 1645                 1650             


Ser Lys  Asp Glu Lys Ile Gly  Glu Thr Val Val Asp  Leu Glu Asn 
    1655                 1660                 1665             


Arg Leu  Leu Ser Lys Phe Gly  Ala Arg Cys Gly Leu  Pro Gln Thr 
    1670                 1675                 1680             


Tyr Cys  Val Ser Gly Pro Asn  Gln Trp Arg Asp Gln  Leu Arg Pro 
    1685                 1690                 1695             


Ser Gln  Leu Leu His Leu Phe  Cys Gln Gln His Arg  Val Lys Ala 
    1700                 1705                 1710             


Pro Val  Tyr Arg Thr Asp Arg  Val Met Phe Gln Asp  Lys Glu Tyr 
    1715                 1720                 1725             


Ser Ile  Glu Glu Ile Glu Ala  Gly Arg Ile Pro Asn  Pro His Leu 
    1730                 1735                 1740             


Gly Pro  Val Glu Glu Arg Leu  Ala Leu His Val Leu  Gln Gln Gln 
    1745                 1750                 1755             


Gly Leu  Val Pro Glu His Val  Glu Ser Arg Pro Leu  Tyr Ser Pro 
    1760                 1765                 1770             


Leu Gln  Pro Asp Ile Glu Gln  Gly Lys Leu Gln Met  Trp Val Asp 
    1775                 1780                 1785             


Leu Phe  Pro Lys Ala Leu Gly  Arg Pro Gly Pro Pro  Phe Asn Ile 
    1790                 1795                 1800             


Thr Pro  Arg Arg Ala Arg Arg  Phe Phe Leu Arg Cys  Ile Ile Trp 
    1805                 1810                 1815             


Asn Thr  Arg Asp Val Ile Leu  Asp Asp Leu Ser Leu  Thr Gly Glu 
    1820                 1825                 1830             


Lys Met  Ser Asp Ile Tyr Val  Lys Gly Trp Met Ile  Gly Phe Glu 
    1835                 1840                 1845             


Glu His  Lys Gln Lys Thr Asp  Val His Tyr Arg Ser  Leu Gly Gly 
    1850                 1855                 1860             


Glu Gly  Asn Phe Asn Trp Arg  Phe Ile Phe Pro Phe  Asp Tyr Leu 
    1865                 1870                 1875             


Pro Ala  Glu Gln Val Cys Thr  Ile Ala Lys Lys Asp  Ala Phe Trp 
    1880                 1885                 1890             


Arg Leu  Asp Lys Thr Glu Ser  Lys Ile Pro Ala Arg  Val Val Phe 
    1895                 1900                 1905             


Gln Ile  Trp Asp Asn Asp Lys  Phe Ser Phe Asp Asp  Phe Leu Gly 
    1910                 1915                 1920             


Ser Leu  Gln Leu Asp Leu Asn  Arg Met Pro Lys Pro  Ala Lys Thr 
    1925                 1930                 1935             


Ala Lys  Lys Cys Ser Leu Asp  Gln Leu Asp Asp Ala  Phe His Pro 
    1940                 1945                 1950             


Glu Trp  Phe Val Ser Leu Phe  Glu Gln Lys Thr Val  Lys Gly Trp 
    1955                 1960                 1965             


Trp Pro  Cys Val Ala Glu Glu  Gly Glu Lys Lys Ile  Leu Ala Gly 
    1970                 1975                 1980             


Lys Leu  Glu Met Thr Leu Glu  Ile Val Ala Glu Ser  Glu His Glu 
    1985                 1990                 1995             


Glu Arg  Pro Ala Gly Gln Gly  Arg Asp Glu Pro Asn  Met Asn Pro 
    2000                 2005                 2010             


Lys Leu  Glu Asp Pro Arg Arg  Pro Asp Thr Ser Phe  Leu Trp Phe 
    2015                 2020                 2025             


Thr Ser  Pro Tyr Lys Thr Met  Lys Phe Ile Leu Trp  Arg Arg Phe 
    2030                 2035                 2040             


Arg Trp  Ala Ile Ile Leu Phe  Ile Ile Leu Phe Ile  Leu Leu Leu 
    2045                 2050                 2055             


Phe Leu  Ala Ile Phe Ile Tyr  Ala Phe Pro Asn Tyr  Ala Ala Met 
    2060                 2065                 2070             


Lys Leu  Val Lys Pro Phe Ser  
    2075                 2080 


<210> 13
<211> 3340
<212> DNA
<213> Homo sapiens

<220>
<223> 5' hDYSF DNA fragment v2

<400> 13
atgctgaggg tcttcatcct ctatgccgag aacgtccaca cacccgacac cgacatcagc       60

gatgcctact gctccgcggt gtttgcaggg gtgaagaaga gaaccaaagt catcaagaac      120

agcgtgaacc ctgtatggaa tgagggattt gaatgggacc tcaagggcat ccccctggac      180

cagggctctg agcttcatgt ggtggtcaaa gaccatgaga cgatggggag gaacaggttc      240

ctgggggaag ccaaggtccc actccgagag gtcctcgcca cccctagtct gtccgccagc      300

ttcaatgccc ccctgctgga caccaagaag cagcccacag gggcctcgct ggtcctgcag      360

gtgtcctaca caccgctgcc tggagctgtg cccctgttcc cgccccctac tcctctggag      420

ccctccccga ctctgcctga cctggatgta gtggcagaca caggaggaga ggaagacaca      480

gaggaccagg gactcactgg agatgaggcg gagccattcc tggatcaaag cggaggcccg      540

ggggctccca ccaccccaag gaaactacct tcacgtcctc cgccccacta ccccgggatc      600

aaaagaaagc gaagtgcgcc tacatctaga aagctgctgt cagacaaacc gcaggatttc      660

cagatcaggg tccaggtgat cgaggggcgc cagctgccgg gggtgaacat caagcctgtg      720

gtcaaggtta ccgctgcagg gcagaccaag cggacgcgga tccacaaggg aaacagccca      780

ctcttcaatg agactctttt cttcaacttg tttgactctc ctggggagct gtttgatgag      840

cccatcttta tcacggtggt agactctcgt tctctcagga cagatgctct cctcggggag      900

ttccggatgg acgtgggcac catttacaga gagccccggc acgcctatct caggaagtgg      960

ctgctgctct cagaccctga tgacttctct gctggggcca gaggctacct gaaaacaagc     1020

ctttgtgtgc tggggcctgg ggacgaagcg cctctggaga gaaaagaccc ctctgaagac     1080

aaggaggaca ttgaaagcaa cctgctccgg cccacaggcg tagccctgcg aggagcccac     1140

ttctgcctga aggtcttccg ggccgaggac ttgccgcaga tggacgatgc cgtgatggac     1200

aacgtgaaac agatctttgg cttcgagagt aacaagaaga acttggtgga cccctttgtg     1260

gaggtcagct ttgcggggaa aatgctgtgc agcaagatct tggagaagac ggccaaccct     1320

cagtggaacc agaacatcac actgcctgcc atgtttccct ccatgtgcga aaaaatgagg     1380

attcgtatca tagactggga ccgcctgact cacaatgaca tcgtggctac cacctacctg     1440

agtatgtcga aaatctctgc ccctggagga gaaatagaag aggagcctgc aggtgctgtc     1500

aagccttcga aagcctcaga cttggatgac tacctgggct tcctccccac ttttgggccc     1560

tgctacatca acctctatgg cagtcccaga gagttcacag gcttcccaga cccctacaca     1620

gagctcaaca caggcaaggg ggaaggtgtg gcttatcgtg gccggcttct gctctccctg     1680

gagaccaagc tggtggagca cagtgaacag aaggtggagg accttcctgc ggatgacatc     1740

ctccgggtgg agaagtacct taggaggcgc aagtactccc tgtttgcggc cttctactca     1800

gccaccatgc tgcaggatgt ggatgatgcc atccagtttg aggtcagcat cgggaactac     1860

gggaacaagt tcgacatgac ctgcctgccg ctggcctcca ccactcagta cagccgtgca     1920

gtctttgacg ggtgccacta ctactaccta ccctggggta acgtgaaacc tgtggtggtg     1980

ctgtcatcct actgggagga catcagccat agaatcgaga ctcagaacca gctgcttggg     2040

attgctgacc ggctggaagc tggcctggag caggtccacc tggccctgaa ggcgcagtgc     2100

tccacggagg acgtggactc gctggtggct cagctgacgg atgagctcat cgcaggctgc     2160

agccagcctc tgggtgacat ccatgagaca ccctctgcca cccacctgga ccagtacctg     2220

taccagctgc gcacccatca cctgagccaa atcactgagg ctgccctggc cctgaagctc     2280

ggccacagtg agctccctgc agctctggag caggcggagg actggctcct gcgtctgcgt     2340

gccctggcag aggagcccca gaacagcctg ccggacatcg tcatctggat gctgcaggga     2400

gacaagcgtg tggcatacca gcgggtgccc gcccaccaag tcctcttctc ccggcggggt     2460

gccaactact gtggcaagaa ttgtgggaag ctacagacaa tctttctgaa atatccgatg     2520

gagaaggtgc ctggcgcccg gatgccagtg cagatacggg tcaagctgtg gtttgggctc     2580

tcagtggatg agaaggagtt caaccagttt gctgagggga agctgtctgt ctttgctgaa     2640

acctatgaga acgagactaa gttggccctt gttgggaact ggggcacaac gggcctcacc     2700

taccccaagt tttctgacgt cacgggcaag atcaagctac ccaaggacag cttccgcccc     2760

tcggccggct ggacctgggc tggagattgg ttcgtgtgtc cggagaagac tctgctccat     2820

gacatggacg ccggtcacct gagcttcgtg gaagaggtgt ttgagaacca gacccggctt     2880

cccggaggcc agtggatcta catgagtgac aactacaccg atgtgaacgg ggagaaggtg     2940

cttcccaagg atgacattga gtgcccactg ggctggaagt gggaagatga ggaatggtcc     3000

acagacctca accgggctgt cgatgagcaa ggctgggagt atagcatcac catccccccg     3060

gagcggaagc cgaagcactg ggtccctgct gagaagatgt actacacaca ccgacggcgg     3120

cgctgggtgc gcctgcgcag gagggatctc agccaaatgg aagcactgaa aaggcacagg     3180

caggcggagg cggagggcga gggctgggag tacgcctctc tttttggctg gaagttccac     3240

ctcgagtacc gcaagacaga tgccttccgc cgccgccgct ggcgccgtcg catggagcca     3300

ctggagaaga cggggcctgc agctgtgttt gcccttgagg                           3340


<210> 14
<211> 3866
<212> DNA
<213> Homo sapiens

<220>
<223> 3' hDYSF DNA fragment v2

<400> 14
tcgtcatctg gatgctgcag ggagacaagc gtgtggcata ccagcgggtg cccgcccacc       60

aagtcctctt ctcccggcgg ggtgccaact actgtggcaa gaattgtggg aagctacaga      120

caatctttct gaaatatccg atggagaagg tgcctggcgc ccggatgcca gtgcagatac      180

gggtcaagct gtggtttggg ctctcagtgg atgagaagga gttcaaccag tttgctgagg      240

ggaagctgtc tgtctttgct gaaacctatg agaacgagac taagttggcc cttgttggga      300

actggggcac aacgggcctc acctacccca agttttctga cgtcacgggc aagatcaagc      360

tacccaagga cagcttccgc ccctcggccg gctggacctg ggctggagat tggttcgtgt      420

gtccggagaa gactctgctc catgacatgg acgccggtca cctgagcttc gtggaagagg      480

tgtttgagaa ccagacccgg cttcccggag gccagtggat ctacatgagt gacaactaca      540

ccgatgtgaa cggggagaag gtgcttccca aggatgacat tgagtgccca ctgggctgga      600

agtgggaaga tgaggaatgg tccacagacc tcaaccgggc tgtcgatgag caaggctggg      660

agtatagcat caccatcccc ccggagcgga agccgaagca ctgggtccct gctgagaaga      720

tgtactacac acaccgacgg cggcgctggg tgcgcctgcg caggagggat ctcagccaaa      780

tggaagcact gaaaaggcac aggcaggcgg aggcggaggg cgagggctgg gagtacgcct      840

ctctttttgg ctggaagttc cacctcgagt accgcaagac agatgccttc cgccgccgcc      900

gctggcgccg tcgcatggag ccactggaga agacggggcc tgcagctgtg tttgcccttg      960

agggggccct gggcggcgtg atggatgaca agagtgaaga ttccatgtcc gtctccacct     1020

tgagcttcgg tgtgaacaga cccacgattt cctgcatatt cgactatggg aaccgctacc     1080

atctacgctg ctacatgtac caggcccggg acctggctgc gatggacaag gactcttttt     1140

ctgatcccta tgccatcgtc tccttcctgc accagagcca gaagacggtg gtggtgaaga     1200

acacccttaa ccccacctgg gaccagacgc tcatcttcta cgagatcgag atctttggcg     1260

agccggccac agttgctgag caaccgccca gcattgtggt ggagctgtac gaccatgaca     1320

cttatggtgc agacgagttt atgggtcgct gcatctgtca accgagtctg gaacggatgc     1380

cacggctggc ctggttccca ctgacgaggg gcagccagcc gtcgggggag ctgctggcct     1440

cttttgagct catccagaga gagaagccgg ccatccacca tattcctggt tttgaggtgc     1500

aggagacatc aaggatcctg gatgagtctg aggacacaga cctgccctac ccaccacccc     1560

agagggaggc caacatctac atggttcctc agaacatcaa gccagcgctc cagcgtaccg     1620

ccatcgagat cctggcatgg ggcctgcgga acatgaagag ttaccagctg gccaacatct     1680

cctcccccag cctcgtggta gagtgtgggg gccagacggt gcagtcctgt gtcatcagga     1740

acctccggaa gaaccccaac tttgacatct gcaccctctt catggaagtg atgctgccca     1800

gggaggagct ctactgcccc cccatcaccg tcaaggtcat cgataaccgc cagtttggcc     1860

gccggcctgt ggtgggccag tgtaccatcc gctccctgga gagcttcctg tgtgacccct     1920

actcggcgga gagtccatcc ccacagggtg gcccagacga tgtgagccta ctcagtcctg     1980

gggaagacgt gctcatcgac attgatgaca aggagcccct catccccatc caggaggaag     2040

agttcatcga ttggtggagc aaattctttg cctccatagg ggagagggaa aagtgcggct     2100

cctacctgga gaaggatttt gacaccctga aggtctatga cacacagctg gagaatgtgg     2160

aggcctttga gggcctgtct gacttttgta acaccttcaa gctgtaccgg ggcaagacgc     2220

aggaggagac agaagatcca tctgtgattg gtgaatttaa gggcctcttc aaaatttatc     2280

ccctcccaga agacccagcc atccccatgc ccccaagaca gttccaccag ctggccgccc     2340

agggacccca ggagtgcttg gtccgtatct acattgtccg agcatttggc ctgcagccca     2400

aggaccccaa tggaaagtgt gatccttaca tcaagatctc catagggaag aaatcagtga     2460

gtgaccagga taactacatc ccctgcacgc tggagcccgt atttggaaag atgttcgagc     2520

tgacctgcac tctgcctctg gagaaggacc taaagatcac tctctatgac tatgacctcc     2580

tctccaagga cgaaaagatc ggtgagacgg tcgtcgacct ggagaacagg ctgctgtcca     2640

agtttggggc tcgctgtgga ctcccacaga cctactgtgt ctctggaccg aaccagtggc     2700

gggaccagct ccgcccctcc cagctcctcc acctcttctg ccagcagcat agagtcaagg     2760

cacctgtgta ccggacagac cgtgtaatgt ttcaggataa agaatattcc attgaagaga     2820

tagaggctgg caggatccca aacccacacc tgggcccagt ggaggagcgt ctggctctgc     2880

atgtgcttca gcagcagggc ctggtcccgg agcacgtgga gtcacggccc ctctacagcc     2940

ccctgcagcc agacatcgag caggggaagc tgcagatgtg ggtcgaccta tttccgaagg     3000

ccctggggcg gcctggacct cccttcaaca tcaccccacg gagagccaga aggtttttcc     3060

tgcgttgtat tatctggaat accagagatg tgatcctgga tgacctgagc ctcacggggg     3120

agaagatgag cgacatttat gtgaaaggtt ggatgattgg ctttgaagaa cacaagcaaa     3180

agacagacgt gcattatcgt tccctgggag gtgaaggcaa cttcaactgg aggttcattt     3240

tccccttcga ctacctgcca gctgagcaag tctgtaccat tgccaagaag gatgccttct     3300

ggaggctgga caagactgag agcaaaatcc cagcacgagt ggtgttccag atctgggaca     3360

atgacaagtt ctcctttgat gattttctgg gctccctgca gctcgatctc aaccgcatgc     3420

ccaagccagc caagacagcc aagaagtgct ccttggacca gctggatgat gctttccacc     3480

cagaatggtt tgtgtccctt tttgagcaga aaacagtgaa gggctggtgg ccctgtgtag     3540

cagaagaggg tgagaagaaa atactggcgg gcaagctgga aatgaccttg gagattgtag     3600

cagagagtga gcatgaggag cggcctgctg gccagggccg ggatgagccc aacatgaacc     3660

ctaagcttga ggacccaagg cgccccgaca cctccttcct gtggtttacc tccccataca     3720

agaccatgaa gttcatcctg tggcggcgtt tccggtgggc catcatcctc ttcatcatcc     3780

tcttcatcct gctgctgttc ctggccatct tcatctacgc cttcccgaac tatgctgcca     3840

tgaagctggt gaagcccttc agctga                                          3866


<210> 15
<211> 4689
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> DYSF F5' Expresson Cassette v2

<400> 15
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctctaga gtttaagctt gcatgtctaa      180

gctagaccct tcagattaaa aataactgag gtaagggcct gggtagggga ggtggtgtga      240

gacgctcctg tctctcctct atctgcccat cggccctttg gggaggagga atgtgcccaa      300

ggactaaaaa aaggccatgg agccagaggg gcgagggcaa cagacctttc atgggcaaac      360

cttggggccc tgctgtctag catgccccac tacgggtcta ggctgcccat gtaaggaggc      420

aaggcctggg gacacccgag atgcctggtt ataattaacc cagacatgtg gctgcccccc      480

cccccccaac acctgctgcc tctaaaaata accctgtccc tggtggatcc cctgcatgcg      540

aagatcttcg aacaaggctg tgggggactg agggcaggct gtaacaggct tgggggccag      600

ggcttatacg tgcctgggac tcccaaagta ttactgttcc atgttcccgg cgaagggcca      660

gctgtccccc gccagctaga ctcagcactt agtttaggaa ccagtgagca agtcagccct      720

tggggcagcc catacaaggc catggggctg ggcaagctgc acgcctgggt ccggggtggg      780

cacggtgccc gggcaacgag ctgaaagctc atctgctctc aggggcccct ccctggggac      840

agcccctcct ggctagtcac accctgtagg ctcctctata taacccaggg gcacaggggc      900

tgccctcatt ctaccaccac ctccacagca cagacagaca ctcaggagca gccagcggcg      960

cgcccaggta agtttagtct ttttgtcttt tatttcaggt cccggatccg gtggtggtgc     1020

aaatcaaaga actgctcctc agtggatgtt gcctttactt ctaggcctgt acggaagtgt     1080

tacttctgct ctaaaagctg cggaattgta cccgcggccg cggctagcca ccatgctgag     1140

ggtcttcatc ctctatgccg agaacgtcca cacacccgac accgacatca gcgatgccta     1200

ctgctccgcg gtgtttgcag gggtgaagaa gagaaccaaa gtcatcaaga acagcgtgaa     1260

ccctgtatgg aatgagggat ttgaatggga cctcaagggc atccccctgg accagggctc     1320

tgagcttcat gtggtggtca aagaccatga gacgatgggg aggaacaggt tcctggggga     1380

agccaaggtc ccactccgag aggtcctcgc cacccctagt ctgtccgcca gcttcaatgc     1440

ccccctgctg gacaccaaga agcagcccac aggggcctcg ctggtcctgc aggtgtccta     1500

cacaccgctg cctggagctg tgcccctgtt cccgccccct actcctctgg agccctcccc     1560

gactctgcct gacctggatg tagtggcaga cacaggagga gaggaagaca cagaggacca     1620

gggactcact ggagatgagg cggagccatt cctggatcaa agcggaggcc cgggggctcc     1680

caccacccca aggaaactac cttcacgtcc tccgccccac taccccggga tcaaaagaaa     1740

gcgaagtgcg cctacatcta gaaagctgct gtcagacaaa ccgcaggatt tccagatcag     1800

ggtccaggtg atcgaggggc gccagctgcc gggggtgaac atcaagcctg tggtcaaggt     1860

taccgctgca gggcagacca agcggacgcg gatccacaag ggaaacagcc cactcttcaa     1920

tgagactctt ttcttcaact tgtttgactc tcctggggag ctgtttgatg agcccatctt     1980

tatcacggtg gtagactctc gttctctcag gacagatgct ctcctcgggg agttccggat     2040

ggacgtgggc accatttaca gagagccccg gcacgcctat ctcaggaagt ggctgctgct     2100

ctcagaccct gatgacttct ctgctggggc cagaggctac ctgaaaacaa gcctttgtgt     2160

gctggggcct ggggacgaag cgcctctgga gagaaaagac ccctctgaag acaaggagga     2220

cattgaaagc aacctgctcc ggcccacagg cgtagccctg cgaggagccc acttctgcct     2280

gaaggtcttc cgggccgagg acttgccgca gatggacgat gccgtgatgg acaacgtgaa     2340

acagatcttt ggcttcgaga gtaacaagaa gaacttggtg gacccctttg tggaggtcag     2400

ctttgcgggg aaaatgctgt gcagcaagat cttggagaag acggccaacc ctcagtggaa     2460

ccagaacatc acactgcctg ccatgtttcc ctccatgtgc gaaaaaatga ggattcgtat     2520

catagactgg gaccgcctga ctcacaatga catcgtggct accacctacc tgagtatgtc     2580

gaaaatctct gcccctggag gagaaataga agaggagcct gcaggtgctg tcaagccttc     2640

gaaagcctca gacttggatg actacctggg cttcctcccc acttttgggc cctgctacat     2700

caacctctat ggcagtccca gagagttcac aggcttccca gacccctaca cagagctcaa     2760

cacaggcaag ggggaaggtg tggcttatcg tggccggctt ctgctctccc tggagaccaa     2820

gctggtggag cacagtgaac agaaggtgga ggaccttcct gcggatgaca tcctccgggt     2880

ggagaagtac cttaggaggc gcaagtactc cctgtttgcg gccttctact cagccaccat     2940

gctgcaggat gtggatgatg ccatccagtt tgaggtcagc atcgggaact acgggaacaa     3000

gttcgacatg acctgcctgc cgctggcctc caccactcag tacagccgtg cagtctttga     3060

cgggtgccac tactactacc taccctgggg taacgtgaaa cctgtggtgg tgctgtcatc     3120

ctactgggag gacatcagcc atagaatcga gactcagaac cagctgcttg ggattgctga     3180

ccggctggaa gctggcctgg agcaggtcca cctggccctg aaggcgcagt gctccacgga     3240

ggacgtggac tcgctggtgg ctcagctgac ggatgagctc atcgcaggct gcagccagcc     3300

tctgggtgac atccatgaga caccctctgc cacccacctg gaccagtacc tgtaccagct     3360

gcgcacccat cacctgagcc aaatcactga ggctgccctg gccctgaagc tcggccacag     3420

tgagctccct gcagctctgg agcaggcgga ggactggctc ctgcgtctgc gtgccctggc     3480

agaggagccc cagaacagcc tgccggacat cgtcatctgg atgctgcagg gagacaagcg     3540

tgtggcatac cagcgggtgc ccgcccacca agtcctcttc tcccggcggg gtgccaacta     3600

ctgtggcaag aattgtggga agctacagac aatctttctg aaatatccga tggagaaggt     3660

gcctggcgcc cggatgccag tgcagatacg ggtcaagctg tggtttgggc tctcagtgga     3720

tgagaaggag ttcaaccagt ttgctgaggg gaagctgtct gtctttgctg aaacctatga     3780

gaacgagact aagttggccc ttgttgggaa ctggggcaca acgggcctca cctaccccaa     3840

gttttctgac gtcacgggca agatcaagct acccaaggac agcttccgcc cctcggccgg     3900

ctggacctgg gctggagatt ggttcgtgtg tccggagaag actctgctcc atgacatgga     3960

cgccggtcac ctgagcttcg tggaagaggt gtttgagaac cagacccggc ttcccggagg     4020

ccagtggatc tacatgagtg acaactacac cgatgtgaac ggggagaagg tgcttcccaa     4080

ggatgacatt gagtgcccac tgggctggaa gtgggaagat gaggaatggt ccacagacct     4140

caaccgggct gtcgatgagc aaggctggga gtatagcatc accatccccc cggagcggaa     4200

gccgaagcac tgggtccctg ctgagaagat gtactacaca caccgacggc ggcgctgggt     4260

gcgcctgcgc aggagggatc tcagccaaat ggaagcactg aaaaggcaca ggcaggcgga     4320

ggcggagggc gagggctggg agtacgcctc tctttttggc tggaagttcc acctcgagta     4380

ccgcaagaca gatgccttcc gccgccgccg ctggcgccgt cgcatggagc cactggagaa     4440

gacggggcct gcagctgtgt ttgcccttga gggcggccgc aataaaagat ctttattttc     4500

attagatctg tgtgttggtt ttttgtgtgt ctagagcatg gcgggttaat cattaactac     4560

aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4620

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     4680

cgagcgcgc                                                             4689


<210> 16
<211> 4592
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> DYSF F3' Expression Cassette v2

<400> 16
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctactta tctacgtagc catgctctgg      180

tcgactctag agttttcgtc atctggatgc tgcagggaga caagcgtgtg gcataccagc      240

gggtgcccgc ccaccaagtc ctcttctccc ggcggggtgc caactactgt ggcaagaatt      300

gtgggaagct acagacaatc tttctgaaat atccgatgga gaaggtgcct ggcgcccgga      360

tgccagtgca gatacgggtc aagctgtggt ttgggctctc agtggatgag aaggagttca      420

accagtttgc tgaggggaag ctgtctgtct ttgctgaaac ctatgagaac gagactaagt      480

tggcccttgt tgggaactgg ggcacaacgg gcctcaccta ccccaagttt tctgacgtca      540

cgggcaagat caagctaccc aaggacagct tccgcccctc ggccggctgg acctgggctg      600

gagattggtt cgtgtgtccg gagaagactc tgctccatga catggacgcc ggtcacctga      660

gcttcgtgga agaggtgttt gagaaccaga cccggcttcc cggaggccag tggatctaca      720

tgagtgacaa ctacaccgat gtgaacgggg agaaggtgct tcccaaggat gacattgagt      780

gcccactggg ctggaagtgg gaagatgagg aatggtccac agacctcaac cgggctgtcg      840

atgagcaagg ctgggagtat agcatcacca tccccccgga gcggaagccg aagcactggg      900

tccctgctga gaagatgtac tacacacacc gacggcggcg ctgggtgcgc ctgcgcagga      960

gggatctcag ccaaatggaa gcactgaaaa ggcacaggca ggcggaggcg gagggcgagg     1020

gctgggagta cgcctctctt tttggctgga agttccacct cgagtaccgc aagacagatg     1080

ccttccgccg ccgccgctgg cgccgtcgca tggagccact ggagaagacg gggcctgcag     1140

ctgtgtttgc ccttgagggg gccctgggcg gcgtgatgga tgacaagagt gaagattcca     1200

tgtccgtctc caccttgagc ttcggtgtga acagacccac gatttcctgc atattcgact     1260

atgggaaccg ctaccatcta cgctgctaca tgtaccaggc ccgggacctg gctgcgatgg     1320

acaaggactc tttttctgat ccctatgcca tcgtctcctt cctgcaccag agccagaaga     1380

cggtggtggt gaagaacacc cttaacccca cctgggacca gacgctcatc ttctacgaga     1440

tcgagatctt tggcgagccg gccacagttg ctgagcaacc gcccagcatt gtggtggagc     1500

tgtacgacca tgacacttat ggtgcagacg agtttatggg tcgctgcatc tgtcaaccga     1560

gtctggaacg gatgccacgg ctggcctggt tcccactgac gaggggcagc cagccgtcgg     1620

gggagctgct ggcctctttt gagctcatcc agagagagaa gccggccatc caccatattc     1680

ctggttttga ggtgcaggag acatcaagga tcctggatga gtctgaggac acagacctgc     1740

cctacccacc accccagagg gaggccaaca tctacatggt tcctcagaac atcaagccag     1800

cgctccagcg taccgccatc gagatcctgg catggggcct gcggaacatg aagagttacc     1860

agctggccaa catctcctcc cccagcctcg tggtagagtg tgggggccag acggtgcagt     1920

cctgtgtcat caggaacctc cggaagaacc ccaactttga catctgcacc ctcttcatgg     1980

aagtgatgct gcccagggag gagctctact gcccccccat caccgtcaag gtcatcgata     2040

accgccagtt tggccgccgg cctgtggtgg gccagtgtac catccgctcc ctggagagct     2100

tcctgtgtga cccctactcg gcggagagtc catccccaca gggtggccca gacgatgtga     2160

gcctactcag tcctggggaa gacgtgctca tcgacattga tgacaaggag cccctcatcc     2220

ccatccagga ggaagagttc atcgattggt ggagcaaatt ctttgcctcc ataggggaga     2280

gggaaaagtg cggctcctac ctggagaagg attttgacac cctgaaggtc tatgacacac     2340

agctggagaa tgtggaggcc tttgagggcc tgtctgactt ttgtaacacc ttcaagctgt     2400

accggggcaa gacgcaggag gagacagaag atccatctgt gattggtgaa tttaagggcc     2460

tcttcaaaat ttatcccctc ccagaagacc cagccatccc catgccccca agacagttcc     2520

accagctggc cgcccaggga ccccaggagt gcttggtccg tatctacatt gtccgagcat     2580

ttggcctgca gcccaaggac cccaatggaa agtgtgatcc ttacatcaag atctccatag     2640

ggaagaaatc agtgagtgac caggataact acatcccctg cacgctggag cccgtatttg     2700

gaaagatgtt cgagctgacc tgcactctgc ctctggagaa ggacctaaag atcactctct     2760

atgactatga cctcctctcc aaggacgaaa agatcggtga gacggtcgtc gacctggaga     2820

acaggctgct gtccaagttt ggggctcgct gtggactccc acagacctac tgtgtctctg     2880

gaccgaacca gtggcgggac cagctccgcc cctcccagct cctccacctc ttctgccagc     2940

agcatagagt caaggcacct gtgtaccgga cagaccgtgt aatgtttcag gataaagaat     3000

attccattga agagatagag gctggcagga tcccaaaccc acacctgggc ccagtggagg     3060

agcgtctggc tctgcatgtg cttcagcagc agggcctggt cccggagcac gtggagtcac     3120

ggcccctcta cagccccctg cagccagaca tcgagcaggg gaagctgcag atgtgggtcg     3180

acctatttcc gaaggccctg gggcggcctg gacctccctt caacatcacc ccacggagag     3240

ccagaaggtt tttcctgcgt tgtattatct ggaataccag agatgtgatc ctggatgacc     3300

tgagcctcac gggggagaag atgagcgaca tttatgtgaa aggttggatg attggctttg     3360

aagaacacaa gcaaaagaca gacgtgcatt atcgttccct gggaggtgaa ggcaacttca     3420

actggaggtt cattttcccc ttcgactacc tgccagctga gcaagtctgt accattgcca     3480

agaaggatgc cttctggagg ctggacaaga ctgagagcaa aatcccagca cgagtggtgt     3540

tccagatctg ggacaatgac aagttctcct ttgatgattt tctgggctcc ctgcagctcg     3600

atctcaaccg catgcccaag ccagccaaga cagccaagaa gtgctccttg gaccagctgg     3660

atgatgcttt ccacccagaa tggtttgtgt ccctttttga gcagaaaaca gtgaagggct     3720

ggtggccctg tgtagcagaa gagggtgaga agaaaatact ggcgggcaag ctggaaatga     3780

ccttggagat tgtagcagag agtgagcatg aggagcggcc tgctggccag ggccgggatg     3840

agcccaacat gaaccctaag cttgaggacc caaggcgccc cgacacctcc ttcctgtggt     3900

ttacctcccc atacaagacc atgaagttca tcctgtggcg gcgtttccgg tgggccatca     3960

tcctcttcat catcctcttc atcctgctgc tgttcctggc catcttcatc tacgccttcc     4020

cgaactatgc tgccatgaag ctggtgaagc ccttcagctg aggactctcc tgccctgtag     4080

aaggggccgt ggggtcccct ccagcatggg actggcctgc ctcctccgcc cagctcggcg     4140

agctcctcca gacctcctag gcctgattgt cctgccaggg tgggcagaca gacagatgga     4200

ccggcccaca ctcccagagt tgctaacatg gagctctgag atcaccccac ttccatcatt     4260

tccttctccc ccaacccaac gcttttttgg atcagctcag acatatttca gtataaaaca     4320

gttggaacca caaaaaaaaa aaaaaaaagt cgacgcggcc gcaataaaag atctttattt     4380

tcattagatc tgtgtgttgg ttttttgtgt gtctagagca tggctacgta gataagtagc     4440

atggcgggtt aatcattaac tacaaggaac ccctagtgat ggagttggcc actccctctc     4500

tgcgcgctcg ctcgctcact gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg     4560

cccgggcggc ctcagtgagc gagcgagcgc gc                                   4592


<210> 17
<211> 128
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> 3' ITR

<400> 17
aggaacccct agtgatggag ttggccactc cctctctgcg cgctcgctcg ctcactgagg       60

ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc      120

gagcgcgc                                                               128


<210> 18
<211> 8341
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Plasmid sequence for DYS F5 Expression Cassette 

<400> 18
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctctaga gtttaagctt gcatgtctaa      180

gctagaccct tcagattaaa aataactgag gtaagggcct gggtagggga ggtggtgtga      240

gacgctcctg tctctcctct atctgcccat cggccctttg gggaggagga atgtgcccaa      300

ggactaaaaa aaggccatgg agccagaggg gcgagggcaa cagacctttc atgggcaaac      360

cttggggccc tgctgtctag catgccccac tacgggtcta ggctgcccat gtaaggaggc      420

aaggcctggg gacacccgag atgcctggtt ataattaacc cagacatgtg gctgcccccc      480

cccccccaac acctgctgcc tctaaaaata accctgtccc tggtggatcc cctgcatgcg      540

aagatcttcg aacaaggctg tgggggactg agggcaggct gtaacaggct tgggggccag      600

ggcttatacg tgcctgggac tcccaaagta ttactgttcc atgttcccgg cgaagggcca      660

gctgtccccc gccagctaga ctcagcactt agtttaggaa ccagtgagca agtcagccct      720

tggggcagcc catacaaggc catggggctg ggcaagctgc acgcctgggt ccggggtggg      780

cacggtgccc gggcaacgag ctgaaagctc atctgctctc aggggcccct ccctggggac      840

agcccctcct ggctagtcac accctgtagg ctcctctata taacccaggg gcacaggggc      900

tgccctcatt ctaccaccac ctccacagca cagacagaca ctcaggagca gccagcggcg      960

cgcccaggta agtttagtct ttttgtcttt tatttcaggt cccggatccg gtggtggtgc     1020

aaatcaaaga actgctcctc agtggatgtt gcctttactt ctaggcctgt acggaagtgt     1080

tacttctgct ctaaaagctg cggaattgta cccgcggccg cggctagcca ccatgctgag     1140

ggtcttcatc ctctatgccg agaacgtcca cacacccgac accgacatca gcgatgccta     1200

ctgctccgcg gtgtttgcag gggtgaagaa gagaaccaaa gtcatcaaga acagcgtgaa     1260

ccctgtatgg aatgagggat ttgaatggga cctcaagggc atccccctgg accagggctc     1320

tgagcttcat gtggtggtca aagaccatga gacgatgggg aggaacaggt tcctggggga     1380

agccaaggtc ccactccgag aggtcctcgc cacccctagt ctgtccgcca gcttcaatgc     1440

ccccctgctg gacaccaaga agcagcccac aggggcctcg ctggtcctgc aggtgtccta     1500

cacaccgctg cctggagctg tgcccctgtt cccgccccct actcctctgg agccctcccc     1560

gactctgcct gacctggatg tagtggcaga cacaggagga gaggaagaca cagaggacca     1620

gggactcact ggagatgagg cggagccatt cctggatcaa agcggaggcc cgggggctcc     1680

caccacccca aggaaactac cttcacgtcc tccgccccac taccccggga tcaaaagaaa     1740

gcgaagtgcg cctacatcta gaaagctgct gtcagacaaa ccgcaggatt tccagatcag     1800

ggtccaggtg atcgaggggc gccagctgcc gggggtgaac atcaagcctg tggtcaaggt     1860

taccgctgca gggcagacca agcggacgcg gatccacaag ggaaacagcc cactcttcaa     1920

tgagactctt ttcttcaact tgtttgactc tcctggggag ctgtttgatg agcccatctt     1980

tatcacggtg gtagactctc gttctctcag gacagatgct ctcctcgggg agttccggat     2040

ggacgtgggc accatttaca gagagccccg gcacgcctat ctcaggaagt ggctgctgct     2100

ctcagaccct gatgacttct ctgctggggc cagaggctac ctgaaaacaa gcctttgtgt     2160

gctggggcct ggggacgaag cgcctctgga gagaaaagac ccctctgaag acaaggagga     2220

cattgaaagc aacctgctcc ggcccacagg cgtagccctg cgaggagccc acttctgcct     2280

gaaggtcttc cgggccgagg acttgccgca gatggacgat gccgtgatgg acaacgtgaa     2340

acagatcttt ggcttcgaga gtaacaagaa gaacttggtg gacccctttg tggaggtcag     2400

ctttgcgggg aaaatgctgt gcagcaagat cttggagaag acggccaacc ctcagtggaa     2460

ccagaacatc acactgcctg ccatgtttcc ctccatgtgc gaaaaaatga ggattcgtat     2520

catagactgg gaccgcctga ctcacaatga catcgtggct accacctacc tgagtatgtc     2580

gaaaatctct gcccctggag gagaaataga agaggagcct gcaggtgctg tcaagccttc     2640

gaaagcctca gacttggatg actacctggg cttcctcccc acttttgggc cctgctacat     2700

caacctctat ggcagtccca gagagttcac aggcttccca gacccctaca cagagctcaa     2760

cacaggcaag ggggaaggtg tggcttatcg tggccggctt ctgctctccc tggagaccaa     2820

gctggtggag cacagtgaac agaaggtgga ggaccttcct gcggatgaca tcctccgggt     2880

ggagaagtac cttaggaggc gcaagtactc cctgtttgcg gccttctact cagccaccat     2940

gctgcaggat gtggatgatg ccatccagtt tgaggtcagc atcgggaact acgggaacaa     3000

gttcgacatg acctgcctgc cgctggcctc caccactcag tacagccgtg cagtctttga     3060

cgggtgccac tactactacc taccctgggg taacgtgaaa cctgtggtgg tgctgtcatc     3120

ctactgggag gacatcagcc atagaatcga gactcagaac cagctgcttg ggattgctga     3180

ccggctggaa gctggcctgg agcaggtcca cctggccctg aaggcgcagt gctccacgga     3240

ggacgtggac tcgctggtgg ctcagctgac ggatgagctc atcgcaggct gcagccagcc     3300

tctgggtgac atccatgaga caccctctgc cacccacctg gaccagtacc tgtaccagct     3360

gcgcacccat cacctgagcc aaatcactga ggctgccctg gccctgaagc tcggccacag     3420

tgagctccct gcagctctgg agcaggcgga ggactggctc ctgcgtctgc gtgccctggc     3480

agaggagccc cagaacagcc tgccggacat cgtcatctgg atgctgcagg gagacaagcg     3540

tgtggcatac cagcgggtgc ccgcccacca agtcctcttc tcccggcggg gtgccaacta     3600

ctgtggcaag aattgtggga agctacagac aatctttctg aaatatccga tggagaaggt     3660

gcctggcgcc cggatgccag tgcagatacg ggtcaagctg tggtttgggc tctctgtgga     3720

tgagaaggag ttcaaccagt ttgctgaggg gaagctgtct gtctttgctg aaacctatga     3780

gaacgagact aagttggccc ttgttgggaa ctggggcaca acgggcctca cctaccccaa     3840

gttttctgac gtcacgggca agatcaagct acccaaggac agcttccgcc cctcggccgg     3900

ctggacctgg gctggagatt ggttcgtgtg tccggagaag actctgctcc atgacatgga     3960

cgccggtcac ctgagcttcg tggaagaggt gtttgagaac cagacccggc ttcccggagg     4020

ccagtggatc tacatgagtg acaactacac cgatgtgaac ggggagaagg tgcttcccaa     4080

ggatgacatt gagtgcccac tgggctggaa gtgggaagat gaggaatggt ccacagacct     4140

caaccgggct gtcgatgagc aaggctggga gtatagcatc accatccccc cggagcggaa     4200

gccgaagcac tgggtccctg ctgagaagat gtactacaca caccgacggc ggcgctgggt     4260

gcgcctgcgc aggagggatc tcagccaaat ggaagcactg aaaaggcaca ggcaggcgga     4320

ggcggagggc gagggctggg agtacgcctc tctttttggc tggaagttcc acctcgagta     4380

ccgcaagaca gatgccttcc gccgccgccg ctggcgccgt cgcatggagc cactggagaa     4440

gacggggcct gcagctgtgt ttgcccttga gggcggccgc aataaaagat ctttattttc     4500

attagatctg tgtgttggtt ttttgtgtgt ctagagcatg gcgggttaat cattaactac     4560

aaggaacccc tagtgatgga gttggccact ccctctctgc gcgctcgctc gctcactgag     4620

gccgggcgac caaaggtcgc ccgacgcccg ggctttgccc gggcggcctc agtgagcgag     4680

cgagcgcgca gctgcattaa tgaatcggcc aacgcgcggg gagaggcggt ttgcgtattg     4740

ggcgctcttc cgcttcctcg ctcactgact cgctgcgctc ggtcgttcgg ctgcggcgag     4800

cggtatcagc tcactcaaag gcggtaatac ggttatccac agaatcaggg gataacgcag     4860

gaaagaacat gtgagcaaaa ggccagcaaa aggccaggaa ccgtaaaaag gccgcgttgc     4920

tggcgttttt ccataggctc cgcccccctg acgagcatca caaaaatcga cgctcaagtc     4980

agaggtggcg aaacccgaca ggactataaa gataccaggc gtttccccct ggaagctccc     5040

tcgtgcgctc tcctgttccg accctgccgc ttaccggata cctgtccgcc tttctccctt     5100

cgggaagcgt ggcgctttct catagctcac gctgtaggta tctcagttcg gtgtaggtcg     5160

ttcgctccaa gctgggctgt gtgcacgaac cccccgttca gcccgaccgc tgcgccttat     5220

ccggtaacta tcgtcttgag tccaacccgg taagacacga cttatcgcca ctggcagcag     5280

ccactggtaa caggattagc agagcgaggt atgtaggcgg tgctacagag ttcttgaagt     5340

ggtggcctaa ctacggctac actagaagaa cagtatttgg tatctgcgct ctgctgaagc     5400

cagttacctt cggaaaaaga gttggtagct cttgatccgg caaacaaacc accgctggta     5460

gcggtggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     5520

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     5580

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     5640

gttttaaatc aatctaaagt atatatgagt aaaaatattc cggaattgcc agctggggcg     5700

ccctctggta aggttgggaa gccctgcaaa gtaaactgga tggctttctt gccgccaagg     5760

atctgatggc gcaggggatc aagatctgat caagagacag gatgaggatc gtttcgcatg     5820

attgaacaag atggattgca cgcaggttct ccggccgctt gggtggagag gctattcggc     5880

tatgactggg cacaacagac aatcggctgc tctgatgccg ccgtgttccg gctgtcagcg     5940

caggggcgcc cggttctttt tgtcaagacc gacctgtccg gtgccctgaa tgaactgcag     6000

gacgaggcag cgcggctatc gtggctggcc acgacgggcg ttccttgcgc agctgtgctc     6060

gacgttgtca ctgaagcggg aagggactgg ctgctattgg gcgaagtgcc ggggcaggat     6120

ctcctgtcat cccaccttgc tcctgccgag aaagtatcca tcatggctga tgcaatgcgg     6180

cggctgcata cgcttgatcc ggctacctgc ccattcgacc accaagcgaa acatcgcatc     6240

gagcgagcac gtactcggat ggaagccggt cttgtcgatc aggatgatct ggacgaagag     6300

catcaggggc tcgcgccagc cgaactgttc gccaggctca aggcgcgcat gcccgacggc     6360

gaggatctcg tcgtgaccca tggcgatgcc tgcttgccga atatcatggt ggaaaatggc     6420

cgcttttctg gattcatcga ctgtggccgg ctgggtgtgg cggaccgcta tcaggacata     6480

gcgttggcta cccgtgatat tgctgaagag cttggcggcg aatgggctga ccgcttcctc     6540

gtgctttacg gtatcgccgc tcccgattcg cagcgcatcg ccttctatcg ccttcttgac     6600

gagttcttct gaaccggtaa tattattgaa gcatttatca gggttattgt ctcatgagcg     6660

gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc acatttcccc     6720

gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc tataaaaata     6780

ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac     6840

acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg agcagacaag     6900

cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat     6960

cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac agatgcgtaa     7020

ggagaaaata ccgcatcagg cgattccaac atccaataaa tcatacaggc aaggcaaaga     7080

attagcaaaa ttaagcaata aagcctcaga gcataaagct aaatcggttg taccaaaaac     7140

attatgaccc tgtaatactt ttgcgggaga agcctttatt tcaacgcaag gataaaaatt     7200

tttagaaccc tcatatattt taaatgcaat gcctgagtaa tgtgtaggta aagattcaaa     7260

cgggtgagaa aggccggaga cagtcaaatc accatcaata tgatattcaa ccgttctagc     7320

tgataaattc atgccggaga gggtagctat ttttgagagg tctctacaaa ggctatcagg     7380

tcattgcctg agagtctgga gcaaacaaga gaatcgatga acggtaatcg taaaactagc     7440

atgtcaatca tatgtacccc ggttgataat cagaaaagcc ccaaaaacag gaagattgta     7500

taagcaaata tttaaattgt aagcgttaat attttgttaa aattcgcgtt aaatttttgt     7560

taaatcagct cattttttaa ccaataggcc gaaatcggca aaatccctta taaatcaaaa     7620

gaatagaccg agatagggtt gagtgttgtt ccagtttgga acaagagtcc actattaaag     7680

aacgtggact ccaacgtcaa agggcgaaaa accgtctatc agggcgatgg cccactacgt     7740

gaaccatcac cctaatcaag ttttttgggg tcgaggtgcc gtaaagcact aaatcggaac     7800

cctaaaggga gcccccgatt tagagcttga cggggaaagc cggcgaacgt ggcgagaaag     7860

gaagggaaga aagcgaaagg agcgggcgct agggcgctgg caagtgtagc ggtcacgctg     7920

cgcgtaacca ccacacccgc cgcgcttaat gcgccgctac agggcgcgta ctatggttgc     7980

tttgacgagc acgtataacg tgctttcctc gttagaatca gagcgggagc taaacaggag     8040

gccgattaaa gggattttag acaggaacgg tacgccagaa tcctgagaag tgtttttata     8100

atcagtgagg ccaccgagta aaagagtctg tccatcacgc aaattaaccg ttgtcgcaat     8160

acttctttga ttagtaataa catcacttgc ctgagtagaa gaactcaaac tatcggcctt     8220

gctggtaata tccagaacaa tattaccgcc agccattgca acggaatcgc cattcgccat     8280

tcaggctgcg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta ttacgccagc     8340

t                                                                     8341


<210> 19
<211> 8244
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> Plasmid sequence for DYS F3 Expression Cassette 

<400> 19
gtagccatgc tctggtcgac tctagagttt tcgtcatctg gatgctgcag ggagacaagc       60

gtgtggcata ccagcgggtg cccgcccacc aagtcctctt ctcccggcgg ggtgccaact      120

actgtggcaa gaattgtggg aagctacaga caatctttct gaaatatccg atggagaagg      180

tgcctggcgc ccggatgcca gtgcagatac gggtcaagct gtggtttggg ctctctgtgg      240

atgagaagga gttcaaccag tttgctgagg ggaagctgtc tgtctttgct gaaacctatg      300

agaacgagac taagttggcc cttgttggga actggggcac aacgggcctc acctacccca      360

agttttctga cgtcacgggc aagatcaagc tacccaagga cagcttccgc ccctcggccg      420

gctggacctg ggctggagat tggttcgtgt gtccggagaa gactctgctc catgacatgg      480

acgccggtca cctgagcttc gtggaagagg tgtttgagaa ccagacccgg cttcccggag      540

gccagtggat ctacatgagt gacaactaca ccgatgtgaa cggggagaag gtgcttccca      600

aggatgacat tgagtgccca ctgggctgga agtgggaaga tgaggaatgg tccacagacc      660

tcaaccgggc tgtcgatgag caaggctggg agtatagcat caccatcccc ccggagcgga      720

agccgaagca ctgggtccct gctgagaaga tgtactacac acaccgacgg cggcgctggg      780

tgcgcctgcg caggagggat ctcagccaaa tggaagcact gaaaaggcac aggcaggcgg      840

aggcggaggg cgagggctgg gagtacgcct ctctttttgg ctggaagttc cacctcgagt      900

accgcaagac agatgccttc cgccgccgcc gctggcgccg tcgcatggag ccactggaga      960

agacggggcc tgcagctgtg tttgcccttg agggggccct gggcggcgtg atggatgaca     1020

agagtgaaga ttccatgtcc gtctccacct tgagcttcgg tgtgaacaga cccacgattt     1080

cctgcatatt cgactatggg aaccgctacc atctacgctg ctacatgtac caggcccggg     1140

acctggctgc gatggacaag gactcttttt ctgatcccta tgccatcgtc tccttcctgc     1200

accagagcca gaagacggtg gtggtgaaga acacccttaa ccccacctgg gaccagacgc     1260

tcatcttcta cgagatcgag atctttggcg agccggccac agttgctgag caaccgccca     1320

gcattgtggt ggagctgtac gaccatgaca cttatggtgc agacgagttt atgggtcgct     1380

gcatctgtca accgagtctg gaacggatgc cacggctggc ctggttccca ctgacgaggg     1440

gcagccagcc gtcgggggag ctgctggcct cttttgagct catccagaga gagaagccgg     1500

ccatccacca tattcctggt tttgaggtgc aggagacatc aaggatcctg gatgagtctg     1560

aggacacaga cctgccctac ccaccacccc agagggaggc caacatctac atggttcctc     1620

agaacatcaa gccagcgctc cagcgtaccg ccatcgagat cctggcatgg ggcctgcgga     1680

acatgaagag ttaccagctg gccaacatct cctcccccag cctcgtggta gagtgtgggg     1740

gccagacggt gcagtcctgt gtcatcagga acctccggaa gaaccccaac tttgacatct     1800

gcaccctctt catggaagtg atgctgccca gggaggagct ctactgcccc cccatcaccg     1860

tcaaggtcat cgataaccgc cagtttggcc gccggcctgt ggtgggccag tgtaccatcc     1920

gctccctgga gagcttcctg tgtgacccct actcggcgga gagtccatcc ccacagggtg     1980

gcccagacga tgtgagccta ctcagtcctg gggaagacgt gctcatcgac attgatgaca     2040

aggagcccct catccccatc caggaggaag agttcatcga ttggtggagc aaattctttg     2100

cctccatagg ggagagggaa aagtgcggct cctacctgga gaaggatttt gacaccctga     2160

aggtctatga cacacagctg gagaatgtgg aggcctttga gggcctgtct gacttttgta     2220

acaccttcaa gctgtaccgg ggcaagacgc aggaggagac agaagatcca tctgtgattg     2280

gtgaatttaa gggcctcttc aaaatttatc ccctcccaga agacccagcc atccccatgc     2340

ccccaagaca gttccaccag ctggccgccc agggacccca ggagtgcttg gtccgtatct     2400

acattgtccg agcatttggc ctgcagccca aggaccccaa tggaaagtgt gatccttaca     2460

tcaagatctc catagggaag aaatcagtga gtgaccagga taactacatc ccctgcacgc     2520

tggagcccgt atttggaaag atgttcgagc tgacctgcac tctgcctctg gagaaggacc     2580

taaagatcac tctctatgac tatgacctcc tctccaagga cgaaaagatc ggtgagacgg     2640

tcgtcgacct ggagaacagg ctgctgtcca agtttggggc tcgctgtgga ctcccacaga     2700

cctactgtgt ctctggaccg aaccagtggc gggaccagct ccgcccctcc cagctcctcc     2760

acctcttctg ccagcagcat agagtcaagg cacctgtgta ccggacagac cgtgtaatgt     2820

ttcaggataa agaatattcc attgaagaga tagaggctgg caggatccca aacccacacc     2880

tgggcccagt ggaggagcgt ctggctctgc atgtgcttca gcagcagggc ctggtcccgg     2940

agcacgtgga gtcacggccc ctctacagcc ccctgcagcc agacatcgag caggggaagc     3000

tgcagatgtg ggtcgaccta tttccgaagg ccctggggcg gcctggacct cccttcaaca     3060

tcaccccacg gagagccaga aggtttttcc tgcgttgtat tatctggaat accagagatg     3120

tgatcctgga tgacctgagc ctcacggggg agaagatgag cgacatttat gtgaaaggtt     3180

ggatgattgg ctttgaagaa cacaagcaaa agacagacgt gcattatcgt tccctgggag     3240

gtgaaggcaa cttcaactgg aggttcattt tccccttcga ctacctgcca gctgagcaag     3300

tctgtaccat tgccaagaag gatgccttct ggaggctgga caagactgag agcaaaatcc     3360

cagcacgagt ggtgttccag atctgggaca atgacaagtt ctcctttgat gattttctgg     3420

gctccctgca gctcgatctc aaccgcatgc ccaagccagc caagacagcc aagaagtgct     3480

ccttggacca gctggatgat gctttccacc cagaatggtt tgtgtccctt tttgagcaga     3540

aaacagtgaa gggctggtgg ccctgtgtag cagaagaggg tgagaagaaa atactggcgg     3600

gcaagctgga aatgaccttg gagattgtag cagagagtga gcatgaggag cggcctgctg     3660

gccagggccg ggatgagccc aacatgaacc ctaagcttga ggacccaagg cgccccgaca     3720

cctccttcct gtggtttacc tccccataca agaccatgaa gttcatcctg tggcggcgtt     3780

tccggtgggc catcatcctc ttcatcatcc tcttcatcct gctgctgttc ctggccatct     3840

tcatctacgc cttcccgaac tatgctgcca tgaagctggt gaagcccttc agctgaggac     3900

tctcctgccc tgtagaaggg gccgtggggt cccctccagc atgggactgg cctgcctcct     3960

ccgcccagct cggcgagctc ctccagacct cctaggcctg attgtcctgc cagggtgggc     4020

agacagacag atggaccggc ccacactccc agagttgcta acatggagct ctgagatcac     4080

cccacttcca tcatttcctt ctcccccaac ccaacgcttt tttggatcag ctcagacata     4140

tttcagtata aaacagttgg aaccacaaaa aaaaaaaaaa aaagtcgacg cggccgcaat     4200

aaaagatctt tattttcatt agatctgtgt gttggttttt tgtgtgtcta gagcatggct     4260

acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta gtgatggagt     4320

tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc     4380

gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcagc tgcattaatg     4440

aatcggccaa cgcgcgggga gaggcggttt gcgtattggg cgctcttccg cttcctcgct     4500

cactgactcg ctgcgctcgg tcgttcggct gcggcgagcg gtatcagctc actcaaaggc     4560

ggtaatacgg ttatccacag aatcagggga taacgcagga aagaacatgt gagcaaaagg     4620

ccagcaaaag gccaggaacc gtaaaaaggc cgcgttgctg gcgtttttcc ataggctccg     4680

cccccctgac gagcatcaca aaaatcgacg ctcaagtcag aggtggcgaa acccgacagg     4740

actataaaga taccaggcgt ttccccctgg aagctccctc gtgcgctctc ctgttccgac     4800

cctgccgctt accggatacc tgtccgcctt tctcccttcg ggaagcgtgg cgctttctca     4860

tagctcacgc tgtaggtatc tcagttcggt gtaggtcgtt cgctccaagc tgggctgtgt     4920

gcacgaaccc cccgttcagc ccgaccgctg cgccttatcc ggtaactatc gtcttgagtc     4980

caacccggta agacacgact tatcgccact ggcagcagcc actggtaaca ggattagcag     5040

agcgaggtat gtaggcggtg ctacagagtt cttgaagtgg tggcctaact acggctacac     5100

tagaagaaca gtatttggta tctgcgctct gctgaagcca gttaccttcg gaaaaagagt     5160

tggtagctct tgatccggca aacaaaccac cgctggtagc ggtggttttt ttgtttgcaa     5220

gcagcagatt acgcgcagaa aaaaaggatc tcaagaagat cctttgatct tttctacggg     5280

gtctgacgct cagtggaacg aaaactcacg ttaagggatt ttggtcatga gattatcaaa     5340

aaggatcttc acctagatcc ttttaaatta aaaatgaagt tttaaatcaa tctaaagtat     5400

atatgagtaa aaatattccg gaattgccag ctggggcgcc ctctggtaag gttgggaagc     5460

cctgcaaagt aaactggatg gctttcttgc cgccaaggat ctgatggcgc aggggatcaa     5520

gatctgatca agagacagga tgaggatcgt ttcgcatgat tgaacaagat ggattgcacg     5580

caggttctcc ggccgcttgg gtggagaggc tattcggcta tgactgggca caacagacaa     5640

tcggctgctc tgatgccgcc gtgttccggc tgtcagcgca ggggcgcccg gttctttttg     5700

tcaagaccga cctgtccggt gccctgaatg aactgcagga cgaggcagcg cggctatcgt     5760

ggctggccac gacgggcgtt ccttgcgcag ctgtgctcga cgttgtcact gaagcgggaa     5820

gggactggct gctattgggc gaagtgccgg ggcaggatct cctgtcatcc caccttgctc     5880

ctgccgagaa agtatccatc atggctgatg caatgcggcg gctgcatacg cttgatccgg     5940

ctacctgccc attcgaccac caagcgaaac atcgcatcga gcgagcacgt actcggatgg     6000

aagccggtct tgtcgatcag gatgatctgg acgaagagca tcaggggctc gcgccagccg     6060

aactgttcgc caggctcaag gcgcgcatgc ccgacggcga ggatctcgtc gtgacccatg     6120

gcgatgcctg cttgccgaat atcatggtgg aaaatggccg cttttctgga ttcatcgact     6180

gtggccggct gggtgtggcg gaccgctatc aggacatagc gttggctacc cgtgatattg     6240

ctgaagagct tggcggcgaa tgggctgacc gcttcctcgt gctttacggt atcgccgctc     6300

ccgattcgca gcgcatcgcc ttctatcgcc ttcttgacga gttcttctga accggtaata     6360

ttattgaagc atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta     6420

gaaaaataaa caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtcta     6480

agaaaccatt attatcatga cattaaccta taaaaatagg cgtatcacga ggccctttcg     6540

tctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc cggagacggt     6600

cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg cgtcagcggg     6660

tgttggcggg tgtcggggct ggcttaacta tgcggcatca gagcagattg tactgagagt     6720

gcaccatatg cggtgtgaaa taccgcacag atgcgtaagg agaaaatacc gcatcaggcg     6780

attccaacat ccaataaatc atacaggcaa ggcaaagaat tagcaaaatt aagcaataaa     6840

gcctcagagc ataaagctaa atcggttgta ccaaaaacat tatgaccctg taatactttt     6900

gcgggagaag cctttatttc aacgcaagga taaaaatttt tagaaccctc atatatttta     6960

aatgcaatgc ctgagtaatg tgtaggtaaa gattcaaacg ggtgagaaag gccggagaca     7020

gtcaaatcac catcaatatg atattcaacc gttctagctg ataaattcat gccggagagg     7080

gtagctattt ttgagaggtc tctacaaagg ctatcaggtc attgcctgag agtctggagc     7140

aaacaagaga atcgatgaac ggtaatcgta aaactagcat gtcaatcata tgtaccccgg     7200

ttgataatca gaaaagcccc aaaaacagga agattgtata agcaaatatt taaattgtaa     7260

gcgttaatat tttgttaaaa ttcgcgttaa atttttgtta aatcagctca ttttttaacc     7320

aataggccga aatcggcaaa atcccttata aatcaaaaga atagaccgag atagggttga     7380

gtgttgttcc agtttggaac aagagtccac tattaaagaa cgtggactcc aacgtcaaag     7440

ggcgaaaaac cgtctatcag ggcgatggcc cactacgtga accatcaccc taatcaagtt     7500

ttttggggtc gaggtgccgt aaagcactaa atcggaaccc taaagggagc ccccgattta     7560

gagcttgacg gggaaagccg gcgaacgtgg cgagaaagga agggaagaaa gcgaaaggag     7620

cgggcgctag ggcgctggca agtgtagcgg tcacgctgcg cgtaaccacc acacccgccg     7680

cgcttaatgc gccgctacag ggcgcgtact atggttgctt tgacgagcac gtataacgtg     7740

ctttcctcgt tagaatcaga gcgggagcta aacaggaggc cgattaaagg gattttagac     7800

aggaacggta cgccagaatc ctgagaagtg tttttataat cagtgaggcc accgagtaaa     7860

agagtctgtc catcacgcaa attaaccgtt gtcgcaatac ttctttgatt agtaataaca     7920

tcacttgcct gagtagaaga actcaaacta tcggccttgc tggtaatatc cagaacaata     7980

ttaccgccag ccattgcaac ggaatcgcca ttcgccattc aggctgcgca actgttggga     8040

agggcgatcg gtgcgggcct cttcgctatt acgccagctg cgcgctcgct cgctcactga     8100

ggccgcccgg gcaaagcccg ggcgtcgggc gacctttggt cgcccggcct cagtgagcga     8160

gcgagcgcgc agagagggag tggccaactc catcactagg ggttccttgt agttaatgat     8220

taacccgcca tgctacttat ctac                                            8244


<210> 20
<211> 7906
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<220>
<223> full DYF expression cassette 

<400> 20
gcgcgctcgc tcgctcactg aggccgcccg ggcaaagccc gggcgtcggg cgacctttgg       60

tcgcccggcc tcagtgagcg agcgagcgcg cagagaggga gtggccaact ccatcactag      120

gggttccttg tagttaatga ttaacccgcc atgctctaga gtttaagctt gcatgtctaa      180

gctagaccct tcagattaaa aataactgag gtaagggcct gggtagggga ggtggtgtga      240

gacgctcctg tctctcctct atctgcccat cggccctttg gggaggagga atgtgcccaa      300

ggactaaaaa aaggccatgg agccagaggg gcgagggcaa cagacctttc atgggcaaac      360

cttggggccc tgctgtctag catgccccac tacgggtcta ggctgcccat gtaaggaggc      420

aaggcctggg gacacccgag atgcctggtt ataattaacc cagacatgtg gctgcccccc      480

cccccccaac acctgctgcc tctaaaaata accctgtccc tggtggatcc cctgcatgcg      540

aagatcttcg aacaaggctg tgggggactg agggcaggct gtaacaggct tgggggccag      600

ggcttatacg tgcctgggac tcccaaagta ttactgttcc atgttcccgg cgaagggcca      660

gctgtccccc gccagctaga ctcagcactt agtttaggaa ccagtgagca agtcagccct      720

tggggcagcc catacaaggc catggggctg ggcaagctgc acgcctgggt ccggggtggg      780

cacggtgccc gggcaacgag ctgaaagctc atctgctctc aggggcccct ccctggggac      840

agcccctcct ggctagtcac accctgtagg ctcctctata taacccaggg gcacaggggc      900

tgccctcatt ctaccaccac ctccacagca cagacagaca ctcaggagca gccagcggcg      960

cgcccaggta agtttagtct ttttgtcttt tatttcaggt cccggatccg gtggtggtgc     1020

aaatcaaaga actgctcctc agtggatgtt gcctttactt ctaggcctgt acggaagtgt     1080

tacttctgct ctaaaagctg cggaattgta cccgcggccg cggctagcca ccatgctgag     1140

ggtcttcatc ctctatgccg agaacgtcca cacacccgac accgacatca gcgatgccta     1200

ctgctccgcg gtgtttgcag gggtgaagaa gagaaccaaa gtcatcaaga acagcgtgaa     1260

ccctgtatgg aatgagggat ttgaatggga cctcaagggc atccccctgg accagggctc     1320

tgagcttcat gtggtggtca aagaccatga gacgatgggg aggaacaggt tcctggggga     1380

agccaaggtc ccactccgag aggtcctcgc cacccctagt ctgtccgcca gcttcaatgc     1440

ccccctgctg gacaccaaga agcagcccac aggggcctcg ctggtcctgc aggtgtccta     1500

cacaccgctg cctggagctg tgcccctgtt cccgccccct actcctctgg agccctcccc     1560

gactctgcct gacctggatg tagtggcaga cacaggagga gaggaagaca cagaggacca     1620

gggactcact ggagatgagg cggagccatt cctggatcaa agcggaggcc cgggggctcc     1680

caccacccca aggaaactac cttcacgtcc tccgccccac taccccggga tcaaaagaaa     1740

gcgaagtgcg cctacatcta gaaagctgct gtcagacaaa ccgcaggatt tccagatcag     1800

ggtccaggtg atcgaggggc gccagctgcc gggggtgaac atcaagcctg tggtcaaggt     1860

taccgctgca gggcagacca agcggacgcg gatccacaag ggaaacagcc cactcttcaa     1920

tgagactctt ttcttcaact tgtttgactc tcctggggag ctgtttgatg agcccatctt     1980

tatcacggtg gtagactctc gttctctcag gacagatgct ctcctcgggg agttccggat     2040

ggacgtgggc accatttaca gagagccccg gcacgcctat ctcaggaagt ggctgctgct     2100

ctcagaccct gatgacttct ctgctggggc cagaggctac ctgaaaacaa gcctttgtgt     2160

gctggggcct ggggacgaag cgcctctgga gagaaaagac ccctctgaag acaaggagga     2220

cattgaaagc aacctgctcc ggcccacagg cgtagccctg cgaggagccc acttctgcct     2280

gaaggtcttc cgggccgagg acttgccgca gatggacgat gccgtgatgg acaacgtgaa     2340

acagatcttt ggcttcgaga gtaacaagaa gaacttggtg gacccctttg tggaggtcag     2400

ctttgcgggg aaaatgctgt gcagcaagat cttggagaag acggccaacc ctcagtggaa     2460

ccagaacatc acactgcctg ccatgtttcc ctccatgtgc gaaaaaatga ggattcgtat     2520

catagactgg gaccgcctga ctcacaatga catcgtggct accacctacc tgagtatgtc     2580

gaaaatctct gcccctggag gagaaataga agaggagcct gcaggtgctg tcaagccttc     2640

gaaagcctca gacttggatg actacctggg cttcctcccc acttttgggc cctgctacat     2700

caacctctat ggcagtccca gagagttcac aggcttccca gacccctaca cagagctcaa     2760

cacaggcaag ggggaaggtg tggcttatcg tggccggctt ctgctctccc tggagaccaa     2820

gctggtggag cacagtgaac agaaggtgga ggaccttcct gcggatgaca tcctccgggt     2880

ggagaagtac cttaggaggc gcaagtactc cctgtttgcg gccttctact cagccaccat     2940

gctgcaggat gtggatgatg ccatccagtt tgaggtcagc atcgggaact acgggaacaa     3000

gttcgacatg acctgcctgc cgctggcctc caccactcag tacagccgtg cagtctttga     3060

cgggtgccac tactactacc taccctgggg taacgtgaaa cctgtggtgg tgctgtcatc     3120

ctactgggag gacatcagcc atagaatcga gactcagaac cagctgcttg ggattgctga     3180

ccggctggaa gctggcctgg agcaggtcca cctggccctg aaggcgcagt gctccacgga     3240

ggacgtggac tcgctggtgg ctcagctgac ggatgagctc atcgcaggct gcagccagcc     3300

tctgggtgac atccatgaga caccctctgc cacccacctg gaccagtacc tgtaccagct     3360

gcgcacccat cacctgagcc aaatcactga ggctgccctg gccctgaagc tcggccacag     3420

tgagctccct gcagctctgg agcaggcgga ggactggctc ctgcgtctgc gtgccctggc     3480

agaggagccc cagaacagcc tgccggacat cgtcatctgg atgctgcagg gagacaagcg     3540

tgtggcatac cagcgggtgc ccgcccacca agtcctcttc tcccggcggg gtgccaacta     3600

ctgtggcaag aattgtggga agctacagac aatctttctg aaatatccga tggagaaggt     3660

gcctggcgcc cggatgccag tgcagatacg ggtcaagctg tggtttgggc tctctgtgga     3720

tgagaaggag ttcaaccagt ttgctgaggg gaagctgtct gtctttgctg aaacctatga     3780

gaacgagact aagttggccc ttgttgggaa ctggggcaca acgggcctca cctaccccaa     3840

gttttctgac gtcacgggca agatcaagct acccaaggac agcttccgcc cctcggccgg     3900

ctggacctgg gctggagatt ggttcgtgtg tccggagaag actctgctcc atgacatgga     3960

cgccggtcac ctgagcttcg tggaagaggt gtttgagaac cagacccggc ttcccggagg     4020

ccagtggatc tacatgagtg acaactacac cgatgtgaac ggggagaagg tgcttcccaa     4080

ggatgacatt gagtgcccac tgggctggaa gtgggaagat gaggaatggt ccacagacct     4140

caaccgggct gtcgatgagc aaggctggga gtatagcatc accatccccc cggagcggaa     4200

gccgaagcac tgggtccctg ctgagaagat gtactacaca caccgacggc ggcgctgggt     4260

gcgcctgcgc aggagggatc tcagccaaat ggaagcactg aaaaggcaca ggcaggcgga     4320

ggcggagggc gagggctggg agtacgcctc tctttttggc tggaagttcc acctcgagta     4380

ccgcaagaca gatgccttcc gccgccgccg ctggcgccgt cgcatggagc cactggagaa     4440

gacggggcct gcagctgtgt ttgcccttga gggggccctg ggcggcgtga tggatgacaa     4500

gagtgaagat tccatgtccg tctccacctt gagcttcggt gtgaacagac ccacgatttc     4560

ctgcatattc gactatggga accgctacca tctacgctgc tacatgtacc aggcccggga     4620

cctggctgcg atggacaagg actctttttc tgatccctat gccatcgtct ccttcctgca     4680

ccagagccag aagacggtgg tggtgaagaa cacccttaac cccacctggg accagacgct     4740

catcttctac gagatcgaga tctttggcga gccggccaca gttgctgagc aaccgcccag     4800

cattgtggtg gagctgtacg accatgacac ttatggtgca gacgagttta tgggtcgctg     4860

catctgtcaa ccgagtctgg aacggatgcc acggctggcc tggttcccac tgacgagggg     4920

cagccagccg tcgggggagc tgctggcctc ttttgagctc atccagagag agaagccggc     4980

catccaccat attcctggtt ttgaggtgca ggagacatca aggatcctgg atgagtctga     5040

ggacacagac ctgccctacc caccacccca gagggaggcc aacatctaca tggttcctca     5100

gaacatcaag ccagcgctcc agcgtaccgc catcgagatc ctggcatggg gcctgcggaa     5160

catgaagagt taccagctgg ccaacatctc ctcccccagc ctcgtggtag agtgtggggg     5220

ccagacggtg cagtcctgtg tcatcaggaa cctccggaag aaccccaact ttgacatctg     5280

caccctcttc atggaagtga tgctgcccag ggaggagctc tactgccccc ccatcaccgt     5340

caaggtcatc gataaccgcc agtttggccg ccggcctgtg gtgggccagt gtaccatccg     5400

ctccctggag agcttcctgt gtgaccccta ctcggcggag agtccatccc cacagggtgg     5460

cccagacgat gtgagcctac tcagtcctgg ggaagacgtg ctcatcgaca ttgatgacaa     5520

ggagcccctc atccccatcc aggaggaaga gttcatcgat tggtggagca aattctttgc     5580

ctccataggg gagagggaaa agtgcggctc ctacctggag aaggattttg acaccctgaa     5640

ggtctatgac acacagctgg agaatgtgga ggcctttgag ggcctgtctg acttttgtaa     5700

caccttcaag ctgtaccggg gcaagacgca ggaggagaca gaagatccat ctgtgattgg     5760

tgaatttaag ggcctcttca aaatttatcc cctcccagaa gacccagcca tccccatgcc     5820

cccaagacag ttccaccagc tggccgccca gggaccccag gagtgcttgg tccgtatcta     5880

cattgtccga gcatttggcc tgcagcccaa ggaccccaat ggaaagtgtg atccttacat     5940

caagatctcc atagggaaga aatcagtgag tgaccaggat aactacatcc cctgcacgct     6000

ggagcccgta tttggaaaga tgttcgagct gacctgcact ctgcctctgg agaaggacct     6060

aaagatcact ctctatgact atgacctcct ctccaaggac gaaaagatcg gtgagacggt     6120

cgtcgacctg gagaacaggc tgctgtccaa gtttggggct cgctgtggac tcccacagac     6180

ctactgtgtc tctggaccga accagtggcg ggaccagctc cgcccctccc agctcctcca     6240

cctcttctgc cagcagcata gagtcaaggc acctgtgtac cggacagacc gtgtaatgtt     6300

tcaggataaa gaatattcca ttgaagagat agaggctggc aggatcccaa acccacacct     6360

gggcccagtg gaggagcgtc tggctctgca tgtgcttcag cagcagggcc tggtcccgga     6420

gcacgtggag tcacggcccc tctacagccc cctgcagcca gacatcgagc aggggaagct     6480

gcagatgtgg gtcgacctat ttccgaaggc cctggggcgg cctggacctc ccttcaacat     6540

caccccacgg agagccagaa ggtttttcct gcgttgtatt atctggaata ccagagatgt     6600

gatcctggat gacctgagcc tcacggggga gaagatgagc gacatttatg tgaaaggttg     6660

gatgattggc tttgaagaac acaagcaaaa gacagacgtg cattatcgtt ccctgggagg     6720

tgaaggcaac ttcaactgga ggttcatttt ccccttcgac tacctgccag ctgagcaagt     6780

ctgtaccatt gccaagaagg atgccttctg gaggctggac aagactgaga gcaaaatccc     6840

agcacgagtg gtgttccaga tctgggacaa tgacaagttc tcctttgatg attttctggg     6900

ctccctgcag ctcgatctca accgcatgcc caagccagcc aagacagcca agaagtgctc     6960

cttggaccag ctggatgatg ctttccaccc agaatggttt gtgtcccttt ttgagcagaa     7020

aacagtgaag ggctggtggc cctgtgtagc agaagagggt gagaagaaaa tactggcggg     7080

caagctggaa atgaccttgg agattgtagc agagagtgag catgaggagc ggcctgctgg     7140

ccagggccgg gatgagccca acatgaaccc taagcttgag gacccaaggc gccccgacac     7200

ctccttcctg tggtttacct ccccatacaa gaccatgaag ttcatcctgt ggcggcgttt     7260

ccggtgggcc atcatcctct tcatcatcct cttcatcctg ctgctgttcc tggccatctt     7320

catctacgcc ttcccgaact atgctgccat gaagctggtg aagcccttca gctgaggact     7380

ctcctgccct gtagaagggg ccgtggggtc ccctccagca tgggactggc ctgcctcctc     7440

cgcccagctc ggcgagctcc tccagacctc ctaggcctga ttgtcctgcc agggtgggca     7500

gacagacaga tggaccggcc cacactccca gagttgctaa catggagctc tgagatcacc     7560

ccacttccat catttccttc tcccccaacc caacgctttt ttggatcagc tcagacatat     7620

ttcagtataa aacagttgga accacaaaaa aaaaaaaaaa aagtcgacgc ggccgcaata     7680

aaagatcttt attttcatta gatctgtgtg ttggtttttt gtgtgtctag agcatggcta     7740

cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     7800

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     7860

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgc                    7906


<210> 21
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 21
His His His His His His 
1               5       


<210> 22
<211> 250
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> misc_feature
<222> (1)..(250)
<223> This sequence may encompass 100-250 nucleotides

<400> 22
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      180

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      240

aaaaaaaaaa                                                             250


