                         SEQUENCE LISTING

<110>  PRECISION BIOSCIENCES, INC.
 
<120>  TREATMENT OF RETINITIS PIGMENTOSA USING IMPROVED ENGINEERED 
       MEGANUCLEASES

<130>  P1090.70035WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/023,665
<151>  2020-05-12

<150>  US 63/068,971
<151>  2020-08-21

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  163
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  1

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Ile Ala Gln Ile Lys Pro Asn Gln Ser 
            20                  25                  30          


Tyr Lys Phe Lys His Gln Leu Ser Leu Ala Phe Gln Val Thr Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Arg Asp Arg Gly Ser Val Ser Asp Tyr Ile Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Trp Arg Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys 
145                 150                 155                 160 


Ser Ser Pro 
            


<210>  2
<211>  9
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  2

Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210>  3
<211>  13706
<212>  DNA
<213>  Homo sapiens

<400>  3
gtgggggacc aggagaaaga aagccaagga agaggaggag gaggaggaga aggaggagaa       60

ggatgctgac ctagcagctc ctctcacagc agctcctctc ttgcagaggc tgaagagcga      120

tttgtgccct gcaagctaag cccctaatcc accgaggcaa aggcaaagcc cctagccggg      180

ctcccgaggg ctgggactcg ggtgccccaa gatggctgca tccagccatc ttggcttaga      240

aagcccccca catgccagct tggccaacac ccacaccatg ggtttctctg gactgcccga      300

cacaaggtgt gggtgctggc caggcctgtg ttcaaatccc agctctgcag aggaactttg      360

accctgcata ccccagattc ctcagtggtc agtggggagt tagaccctct tcataggggg      420

caggaggagt tgttcattca ttcaacaaat gtttattgaa cacctcctat gggttgtgag      480

ctcagaggca gcgatgaaca ggccaggctg gtcctgcatt ctagaaatag atgggaagtc      540

agtcaataag tagacaaatg aggccaggtg tggtggcatg cctgtagacc cagttactcg      600

ggatgctgag gtaggaggat cacttgagcc taggacagga attcaaggct gcagtaagct      660

atgattgcgc cactgcactc cagcctgggc aacagagcaa gactcatctc taaaaaacat      720

ttaaaaattg ttttaagaag acaaatgaga tagtcgctga tggtaatgac tgtgtaaaaa      780

ctgaacatgg ctgggtgtgg ttgctcacac ctataatctc agcactttgg gaggctgaga      840

ttacagcctc ccaagtggct cccaaggcag gaggatcact tgagcctggg agttagagaa      900

cagcttggac aatataggga gagcccaact ctacaaaaat gaaaataaat tagccaggca      960

tggtggcaca caccaatggt cccagctact caggggttga ggtggtggac cgcttgagcc     1020

caggaggttg aggctgcagt gagccatgat catgccgctg cactccaacc tgagtcacag     1080

agtgataccc tgtctcaaaa aacaataggc caggtgtggt ggctcacgcc tgtaacccca     1140

gcactttggg aggccgaggc ggatggatca cttgagatca ggagttagag accagcctgg     1200

ctaacatggc aaaatcctgt ctgtactaaa aatataaaaa ttagccaggc atggcagtac     1260

atgcctgtag tcctggttac ttgggaggct aaggcaggag aatcgcttga acccaggaag     1320

aggaggttgc agtgagccaa gatcacacca ctgcactcca gcttgggtga cagagtgaga     1380

ccctgtctca aaacagctaa acctggtggg ggtgcctggt gtgtaggatg gtcaggggtg     1440

gtctctccaa ggacatgagt gtgagcggag acctgaagga gactcaggaa gagattaata     1500

ctgtcagcaa caaatatatt gatcacttac aagcactccc aataatccta ttaggtaggc     1560

actattatca ttcccatttt acagagtgga gaaccgaagc acactctcgg gagggcgggg     1620

tagctggctg cacccaggct gtgtagcctc agtccagatg taagggtggg tggaaaagag     1680

ccttgcccaa tgagggagaa cagtgaaacc aaggccatag ggtctaaaga ttcacgaacc     1740

aggctctcat ggagaaagca ggtgaggttt actgtataga tgggtgtgcc cctaccccac     1800

actgaggctt cctcgtctga gcaaactgag gcccagagag gggaaggaag caggactacc     1860

atggtgactc aaagaccagc tagaatccag cctcctctcc tcgaggcttc cactgcccca     1920

cgccaggcct gtgtgactca gtctagggcc tttccattac cccagctaaa cctttcttta     1980

gtcatttata ccatggtgtg aatggctggc tggtctttcc tgagagctat ctttgatgag     2040

gggagggagg catagccagg tttgggaagc tgatacccca ggaagcccag ttgactgtgt     2100

gggttatagc ccaggctgtc actgatttgt aacgggacct gagcaactct gcagagctag     2160

gcctcagtct tttcatctgc aaaatggata tagcagagat ggtcagagta ggtgacttcg     2220

aatgaccctt ccagctcact atgagtctgt tttcctgaac aaagagcatt ttttgtttaa     2280

aaaaaaattt cttgggccgg acacggtggt tcactcctat aatcctggca ctttgggagg     2340

ccgaggaggg tggatcgctt gagccaggag ttcaggacca gcctgggcaa catagcgaga     2400

ctccacccct acaaaaaata caaaaactag tggtgtgcac ttgtggtccc agctactcag     2460

gaggctgagg tgagaggatc gcttgagccc aggaggcaga ggctacagtg agctatgatt     2520

gtggcactgc actccagcct gggcgacaga gaccttgtct caaaactttt tttttcttcg     2580

tcaagcttta cagaataaag agcactgtca cctcagtgat ggctgttagt tccccatcac     2640

cagggctcca tgaggttgca attgtgaaac tcacaaagga ggaacctgag acagagaggg     2700

gaagtactga gatcatctag gtccattccc ccactcactc gttcattcaa caaatattca     2760

ggagcacctt ctaggtgcca ggccctggag acacatcagt gaacaaaaca gacatcatcc     2820

cacctctttc cactacaggc caagcaccat gctggtctct gggaaccctg ttgtgagcaa     2880

gacagaccca ggcttaccct tgtggactca tgttacaggc agggagacgg gcacaaaaca     2940

caaataaaaa gcttccatgc tgtcagaagc actatgcaaa aagcaagatg ctgaggtact     3000

gctaagctgt gtgggatggg ggctcagccc ggccagggag gggccagttg tgggtcagtc     3060

ttgacccaag gcatccagga caccctcctt ctggccatga gggtccacgt cagaatcaaa     3120

ccctcacctt aacctcatta gcgttgggca taatcaccag gccaagcgcc ttaaactacg     3180

agaggcccca tcccacccgc cctgccttag ccctgccacg tgtgccaaac gctgttagac     3240

ccaacaccac ccaggccagg tagggggctg gagcccaggt gggctgcagg gaagggggca     3300

ctcttctgag cagacagatc tgggaatcct gggtgggaag agagacagtg agagagagat     3360

taagggatat ttcccaggca tcagggcttt gcactctcag gggtccttcc gcctggatgt     3420

ccttcccctg aagcttcctc ctgttgttcc gttctcagct caagctccag cttctcagag     3480

aagcctcctg tgttgggagt ggctgcgact gaactgtccc tactgttatt cgctcttcta     3540

tttgtttgtg gtccctgtgc cccctcaccc cacaaaaaca ctggcttctt gtgagcagga     3600

gcttgctctt tcgtgtaccc tgtgtgtccc caaggaccaa gcaccttgtc tgggccacag     3660

taggtgctca atacacatgt tggctggaca gtggtcactg agcggccgca cgtcgggcac     3720

tctcagcact tgcacaggcc gccccagaca ccccacttca ttcctgggag gtgtcatcat     3780

gttgcttgga cgacggggag agggggacct gccagtgttg gcctccattt tcccccagtc     3840

atctgccccc aaggctctga ctactttctt tctcacggta catcctgcta ttctggaatc     3900

ggccctcgtg gggccacctg gtacatggca tttgaggccc tcgtggctga ttaggcctcc     3960

cccaacagtg ccctgtctgc tgcctccagg gccagcctcc ccttcagact ggagtcccct     4020

gaagggttct gcccctcccc tgctctggta gccccctcca tcctccctcc ctccactcca     4080

tctttggggg catttgagtc acctttctac accagtgatc tgcccaagcc actgctcact     4140

ttcctctgga taaagccagg ttccccggcc tagcgttcaa gacccattac aactgccccc     4200

agcccagatc ttccccacct agccacctgg caaactgctc cttctctcaa aggcccaaac     4260

atggcctccc agactgcaac ccccaggcag tcaggccctg tctccacaac ctcacagcca     4320

ccctggacgg aatctgcttc ttcccacatt tgagtcctcc tcagcccctg agctcctctg     4380

ggcagggctg tttctttcca tctttgtatt cccaggggcc tgcaaataaa tgtttaatga     4440

acgaacaaga gagtgaattc caattccatg caacaaggat tgggctcctg ggccctaggc     4500

tatgtgtctg gcaccagaaa cggaagctgc aggttgcagc ccctgccctc atggagctcc     4560

tcctgtcaga ggagtgtggg gactggatga ctccagaggt aacttgtggg ggaacgaaca     4620

ggtaaggggc tgtgtgacga gatgagagac tgggagaata aaccagaaag tctctagctg     4680

tccagaggac atagcacaga ggcccatggt ccctatttca aacccaggcc accagactga     4740

gctgggacct tgggacagac aagtcatgca gaagttaggg gaccttctcc tcccttttcc     4800

tggatcctga gtacctctcc tccctgacct caggcttcct cctagtgtca ccttggcccc     4860

tcttagaagc caattaggcc ctcagtttct gcagcgggga ttaatatgat tatgaacacc     4920

cccaatctcc cagatgctga ttcagccagg agcttaggag ggggaggtca ctttataagg     4980

gtctgggggg gtcagaaccc agagtcatcc agctggagcc ctgagtggct gagctcaggc     5040

cttcgcagca ttcttgggtg ggagcagcca cgggtcagcc acaagggcca cagccatgaa     5100

tggcacagaa ggccctaact tctacgtgcc cttctccaat gcgacgggtg tggtacgcag     5160

ccccttcgag tacccacagt actacctggc tgagccatgg cagttctcca tgctggccgc     5220

ctacatgttt ctgctgatcg tgctgggctt ccccatcaac ttcctcacgc tctacgtcac     5280

cgtccagcac aagaagctgc gcacgcctct caactacatc ctgctcaacc tagccgtggc     5340

tgacctcttc atggtcctag gtggcttcac cagcaccctc tacacctctc tgcatggata     5400

cttcgtcttc gggcccacag gatgcaattt ggagggcttc tttgccaccc tgggcggtat     5460

gagccgggtg tgggtggggt gtgcaggagc ccgggagcat ggaggggtct gggagagtcc     5520

cgggcttggc ggtggtggct gagaggcctt ctcccttctc ctgtcctgtc aatgttatcc     5580

aaagccctca tatattcagt caacaaacac cattcatggt gatagccggg ctgctgtttg     5640

tgcagggctg gcactgaaca ctgccttgat cttatttgga gcaatatgcg cttgtctaat     5700

ttcacagcaa gaaaactgag ctgaggctca aagaagtcaa gcgccctgct ggggcgtcac     5760

acagggacgg gtgcagagtt gagttggaag cccgcatcta tctcgggcca tgtttgcagc     5820

accaagcctc tgtttccctt ggagcagctg tgctgagtca gacccaggct gggcactgag     5880

ggagagctgg gcaagccaga cccctcctct ctgggggccc aagctcaggg tgggaagtgg     5940

attttccatt ctccagtcat tgggtcttcc ctgtgctggg caatgggctc ggtcccctct     6000

ggcatcctct gcctcccctc tcagcccctg tcctcaggtg cccctccagc ctccctgccg     6060

cgttccaagt ctcctggtgt tgagaaccgc aagcagccgc tctgaagcag ttcctttttg     6120

ctttagaata atgtcttgca tttaacagga aaacagatgg ggtgctgcag ggataacaga     6180

tcccacttaa cagagaggaa aactgaggca gggagagggg aagagactca tttagggatg     6240

tggccaggca gcaacaagag cctaggtctc ctggctgtga tccaggaata tctctgctga     6300

gatgcaggag gagacgctag aagcagccat tgcaaagctg ggtgacgggg agagcttacc     6360

gccagccaca agcgtctctc tgccagcctt gccctgtctc ccccatgtcc aggctgctgc     6420

ctcggtccca ttctcaggga atctctggcc attgttgggt gtttgttgca ttcaataatc     6480

acagatcact cagttctggc cagaaggtgg gtgtgccact tacgggtggt tgttctctgc     6540

agggtcagtc ccagtttaca aatattgtcc ctttcactgt taggaatgtc ccagtttggt     6600

tgattaacta tatggccact ctccctatgg aacttcatgg ggtggtgagc aggacagatg     6660

tctgaattcc atcatttcct tcttcttcct ctgggcaaaa cattgcacat tgcttcatgg     6720

ctcctaggag aggcccccac atgtccgggt tatttcattt cccgagaagg gagagggagg     6780

aaggactgcc aattctgggt ttccaccacc tctgcattcc ttcccaacaa ggaactctgc     6840

cccacattag gatgcattct tctgctaaac acacacacac acacacacac acacaacaca     6900

cacacacaca cacacacaca cacacacaca aaactcccta ccgggttccc agttcaatcc     6960

tgaccccctg atctgattcg tgtcccttat gggcccagag cgctaagcaa ataacttccc     7020

ccattccctg gaatttcttt gcccagctct cctcagcgtg tggtccctct gccccttccc     7080

cctcctccca gcaccaagct ctctccttcc ccaaggcctc ctcaaatccc tctcccactc     7140

ctggttgcct tcctagctac cctctccctg tctagggggg agtgcaccct ccttaggcag     7200

tggggtctgt gctgaccgcc tgctgactgc cttgcaggtg aaattgccct gtggtccttg     7260

gtggtcctgg ccatcgagcg gtacgtggtg gtgtgtaagc ccatgagcaa cttccgcttc     7320

ggggagaacc atgccatcat gggcgttgcc ttcacctggg tcatggcgct ggcctgcgcc     7380

gcacccccac tcgccggctg gtccaggtaa tggcactgag cagaagggaa gaagctccgg     7440

gggctctttg tagggtcctc cagtcaggac tcaaacccag tagtgtctgg ttccaggcac     7500

tgaccttgta tgtctcctgg cccaaatgcc cactcagggt aggggtgtag ggcagaagaa     7560

gaaacagact ctaatgttgc tacaagggct ggtcccatct cctgagcccc atgtcaaaca     7620

gaatccaaga catcccaacc cttcaccttg gctgtgcccc taatcctcaa ctaagctagg     7680

cgcaaattcc aatcctcttt ggtctagtac cccgggggca gccccctcta accttgggcc     7740

tcagcagcag gggaggccac accttcctag tgcaggtggc catattgtgg ccccttggaa     7800

ctgggtccca ctcagcctct aggcgattgt ctcctaatgg ggctgagatg agacacagtg     7860

gggacagtgg tttggacaat aggactggtg actctggtcc ccagaggcct catgtccctc     7920

tgtctccaga aaattcccac tctcacttcc ctttcctcct cagtcttgct agggtccatt     7980

tcttacccct tgctgaattt gagcccaccc cctggacttt ttccccatct tctccaatct     8040

ggcctagttc tatcctctgg aagcagagcc gctggacgct ctgggtttcc tgaggcccgt     8100

ccactgtcac caatatcagg aaccattgcc acgtcctaat gacgtgcgct ggaagcctct     8160

agtttccaga agctgcacaa agatccctta gatactctgt gtgtccatct ttggcctgga     8220

aaatactctc accctggggc taggaagacc tcggtttgta caaacttcct caaatgcaga     8280

gcctgagggc tctccccacc tcctcaccaa ccctctgcgt ggcatagccc tagcctcagc     8340

gggcagtgga tgctggggct gggcatgcag ggagaggctg ggtggtgtca tctggtaacg     8400

cagccaccaa acaatgaagc gacactgatt ccacaaggtg catctgcatc cccatctgat     8460

ccattccatc ctgtcaccca gccatgcaga cgtttatgat ccccttttcc agggagggaa     8520

tgtgaagccc cagaaagggc cagcgctcgg cagccacctt ggctgttccc aagtccctca     8580

caggcagggt ctccctacct gcctgtcctc aggtacatcc ccgagggcct gcagtgctcg     8640

tgtggaatcg actactacac gctcaagccg gaggtcaaca acgagtcttt tgtcatctac     8700

atgttcgtgg tccacttcac catccccatg attatcatct ttttctgcta tgggcagctc     8760

gtcttcaccg tcaaggaggt acgggccggg gggtgggcgg cctcacggct ctgagggtcc     8820

agcccccagc atgcatctgc ggctcctgct ccctggagga gccatggtct ggacccgggt     8880

cccgtgtcct gcaggccgct gcccagcagc aggagtcagc caccacacag aaggcagaga     8940

aggaggtcac ccgcatggtc atcatcatgg tcatcgcttt cctgatctgc tgggtgccct     9000

acgccagcgt ggcattctac atcttcaccc accagggctc caacttcggt cccatcttca     9060

tgaccatccc agcgttcttt gccaagagcg ccgccatcta caaccctgtc atctatatca     9120

tgatgaacaa gcaggtgcct actgcgggtg ggagggcccc agtgccccag gccacaggcg     9180

ctgcctgcca aggacaagct acttcccagg gcaggggagg gggctccatc agggttactg     9240

gcagcagtct tgggtcagca gtcccaatgg ggagtgtgtg agaaatgcag attcctggcc     9300

ccactcagaa ctgctgaatc tcagggtggg cccaggaacc tgcatttcca gcaagccctc     9360

cacaggtggc tcagatgctc actcaggtgg gagaagctcc agtcagctag ttctggaagc     9420

ccaatgtcaa agtcagaagg acccaagtcg ggaatgggat gggccagtct ccataaagct     9480

gaataaggag ctaaaaagtc ttattctgag gggtaaaggg gtaaagggtt cctcggagag     9540

gtacctccga ggggtaaaca gttgggtaaa cagtctctga agtcagctct gccattttct     9600

agctgtatgg ccctgggcaa gtcaatttcc ttctctgtgc tttggtttcc tcatccatag     9660

aaaggtagaa agggcaaaac accaaactct tggattacaa gagataattt acagaacacc     9720

cttggcacac agagggcacc atgaaatgtc acgggtgaca cagccccctt gtgctcagtc     9780

cctggcatct ctaggggtga ggagcgtctg cctagcaggt tccctccagg aagctggatt     9840

tgagtggatg gggcgctgga atcgtgaggg gcagaagcag gcaaagggtc ggggcgaacc     9900

tcactaacgt gccagttcca agcacactgt gggcagccct ggccctgact caagcctctt     9960

gccttccagt tccggaactg catgctcacc accatctgct gcggcaagaa cccactgggt    10020

gacgatgagg cctctgctac cgtgtccaag acggagacga gccaggtggc cccggcctaa    10080

gacctgccta ggactctgtg gccgactata ggcgtctccc atcccctaca ccttccccca    10140

gccacagcca tcccaccagg agcagcgcct gtgcagaatg aacgaagtca cataggctcc    10200

ttaatttttt tttttttttt aagaaataat taatgaggct cctcactcac ctgggacagc    10260

ctgagaaggg acatccacca agacctactg atctggagtc ccacgttccc caaggccagc    10320

gggatgtgtg cccctcctcc tcccaactca tctttcagga acacgaggat tcttgctttc    10380

tggaaaagtg tcccagctta gggataagtg tctagcacag aatggggcac acagtaggtg    10440

cttaataaat gctggatgga tgcaggaagg aatggaggaa tgaatgggaa gggagaacat    10500

atctatcctc tcagaccctc gcagcagcag caactcatac ttggctaatg atatggagca    10560

gttgtttttc cctccctggg cctcactttc ttctcctata aaatggaaat cccagatccc    10620

tggtcctgcc gacacgcagc tactgagaag accaaaagag gtgtgtgtgt gtctatgtgt    10680

gtgtttcagc actttgtaaa tagcaagaag ctgtacagat tctagttaat gttgtgaata    10740

acatcaatta atgtaactag ttaattacta tgattatcac ctcctgatag tgaacatttt    10800

gagattgggc attcagatga tggggtttca cccaaccttg gggcaggttt ttaaaaatta    10860

gctaggcatc aaggccagac cagggctggg ggttgggctg taggcaggga cagtcacagg    10920

aatgcagaat gcagtcatca gacctgaaaa aacaacactg ggggaggggg acggtgaagg    10980

ccaagttccc aatgagggtg agattgggcc tggggtctca cccctagtgt ggggccccag    11040

gtcccgtgcc tccccttccc aatgtggcct atggagagac aggcctttct ctcagcctct    11100

ggaagccacc tgctcttttg ctctagcacc tgggtcccag catctagagc atggagcctc    11160

tagaagccat gctcacccgc ccacatttaa ttaacagctg agtccctgat gtcatcctta    11220

tctcgaagag cttagaaaca aagagtggga aattccactg ggcctacctt ccttggggat    11280

gttcatgggc cccagtttcc agtttccctt gccagacaag cccatcttca gcagttgcta    11340

gtccattctc cattctggag aatctgctcc aaaaagctgg ccacatctct gaggtgtcag    11400

aattaagctg cctcagtaac tgctccccct tctccatata agcaaagcca gaagctctag    11460

ctttacccag ctctgcctgg agactaaggc aaattgggcc attaaaagct cagctcctat    11520

gttggtatta acggtggtgg gttttgttgc tttcacactc tatccacagg atagattgaa    11580

actgccagct tccacctgat ccctgaccct gggatggctg gattgagcaa tgagcagagc    11640

caagcagcac agagtcccct ggggctagag gtggaggagg cagtcctggg aatgggaaaa    11700

accccaactt tggggtcata gaggcacagg taacccataa aactgcaaac aagctttgtc    11760

acctctcaga gcttccttat ctgcaaaaaa gaatcttaaa actgaccttg gctgggcaca    11820

gtggctcaca cctctaatcc cagcactttg ggaggccaag gtgggcagat cacgaggtca    11880

ggagtttgag accagcctga ccaacacggt gaaaccctgt ctctactaaa aatacaaaaa    11940

tcagctgggc atggtggcgc gtgcctgtaa tcccagctat tcagtgggct gaggcaggag    12000

aatcgcttga acctgggagg tggaggttgc agtgagccga gattgcgcca ctgcactcca    12060

gcctgagcaa cagagggaca gtctgtctcc aaacaaaaca aaacaaacaa acaaacaaac    12120

aaacaaacaa aaaacaacaa caaaaaaacc acttgatcct aaggggatta gatgcgactg    12180

tggactttaa gtggccagcc tactgcctgg catgcagcag atgagactat ggcaatactg    12240

ggcttcagct cagagctggc cttactagag accctgtccc aaaggggaaa aggatggagc    12300

taaagctccc gagagtcacc ccctcctccg aggtgagaaa ggagggcagg agcatgagat    12360

agccgatcct cggtgccttg gtgaggctgg ggcaaatcat gctgggatct ctatcattgt    12420

ccctctttac tgtgactcac tagataatat cagtcaggat acttttggtc acaagtgata    12480

ggaaatccaa ctcatttggg ctgaagcaaa agggacacat tgttggctca catgaacaaa    12540

aagcccgggg cttcaggcac agggtatcac catgactgag atggggatta attctgtgat    12600

tggccaagtc taggtcacct gatcatacgt aactcattta tgcctgaggt tgcaattttt    12660

tggatttttg caatcagacc ttggcgatga ccttgagcag taggatataa ataactccca    12720

catgcttagc gttccaataa tggaatacta ggcatacgca ggtctaactg catcaccatg    12780

gctggaatgg ggattcatcc tctgattggt cagacctagg tcacatgctc accctgcagc    12840

ccaagcaggc tgaatgggga gaggtaggtt tcacaaagga aagcccaggt gctgttacct    12900

gaagtaggag ggcaggaggc agggtgagca gagccaacat caacccagag ggaatggaat    12960

ctaagttggt gttttctggg cacgtggctg gaccaggcct ccctccctca tcatctcagg    13020

gacatgaggg agaagattcc tatgggtggt cccgaaggtc tcaccctttg ttttggatgc    13080

tgtgttgggc cagggtggca gtgggtggga cagtggcatc ttagctgccc tgacttgcag    13140

gcagcccatt ccagctcccc gccccaaccc caacccagcc cactttttct gagaaatggt    13200

acatttgccc cagcctcatg tccagaggaa aattttactc taacaccaga acattctctg    13260

gtttgtcctg atagacaaga aagcctccac ctccttaatt tacaaatgac ttgacagctg    13320

cttcgtgggc acttgcatac ataaagagaa ggagctgctg ccttaagttg cagcaagttt    13380

ggccccacct catctccagg cagccagcag atgtacagag tgcctcttgg gtacaatggc    13440

agctccattc aaccaaacct gagcaagctg accccatgcc agaatgcact ggggactcgg    13500

agatgaattg gagcctagag accaagtctc taggctatga cctgggctgc ctcacggcca    13560

cagagctctg tcacgccaag ggagagatgc acccctgaaa gcctgaggtg ccccataagg    13620

agagagtggg tgcccttccc aactatgtag cttcagggca agttctcttt ctttcttttt    13680

ctttctttct ctttctttct ttcttt                                         13706


<210>  4
<211>  13706
<212>  DNA
<213>  Homo sapiens

<400>  4
gtgggggacc aggagaaaga aagccaagga agaggaggag gaggaggaga aggaggagaa       60

ggatgctgac ctagcagctc ctctcacagc agctcctctc ttgcagaggc tgaagagcga      120

tttgtgccct gcaagctaag cccctaatcc accgaggcaa aggcaaagcc cctagccggg      180

ctcccgaggg ctgggactcg ggtgccccaa gatggctgca tccagccatc ttggcttaga      240

aagcccccca catgccagct tggccaacac ccacaccatg ggtttctctg gactgcccga      300

cacaaggtgt gggtgctggc caggcctgtg ttcaaatccc agctctgcag aggaactttg      360

accctgcata ccccagattc ctcagtggtc agtggggagt tagaccctct tcataggggg      420

caggaggagt tgttcattca ttcaacaaat gtttattgaa cacctcctat gggttgtgag      480

ctcagaggca gcgatgaaca ggccaggctg gtcctgcatt ctagaaatag atgggaagtc      540

agtcaataag tagacaaatg aggccaggtg tggtggcatg cctgtagacc cagttactcg      600

ggatgctgag gtaggaggat cacttgagcc taggacagga attcaaggct gcagtaagct      660

atgattgcgc cactgcactc cagcctgggc aacagagcaa gactcatctc taaaaaacat      720

ttaaaaattg ttttaagaag acaaatgaga tagtcgctga tggtaatgac tgtgtaaaaa      780

ctgaacatgg ctgggtgtgg ttgctcacac ctataatctc agcactttgg gaggctgaga      840

ttacagcctc ccaagtggct cccaaggcag gaggatcact tgagcctggg agttagagaa      900

cagcttggac aatataggga gagcccaact ctacaaaaat gaaaataaat tagccaggca      960

tggtggcaca caccaatggt cccagctact caggggttga ggtggtggac cgcttgagcc     1020

caggaggttg aggctgcagt gagccatgat catgccgctg cactccaacc tgagtcacag     1080

agtgataccc tgtctcaaaa aacaataggc caggtgtggt ggctcacgcc tgtaacccca     1140

gcactttggg aggccgaggc ggatggatca cttgagatca ggagttagag accagcctgg     1200

ctaacatggc aaaatcctgt ctgtactaaa aatataaaaa ttagccaggc atggcagtac     1260

atgcctgtag tcctggttac ttgggaggct aaggcaggag aatcgcttga acccaggaag     1320

aggaggttgc agtgagccaa gatcacacca ctgcactcca gcttgggtga cagagtgaga     1380

ccctgtctca aaacagctaa acctggtggg ggtgcctggt gtgtaggatg gtcaggggtg     1440

gtctctccaa ggacatgagt gtgagcggag acctgaagga gactcaggaa gagattaata     1500

ctgtcagcaa caaatatatt gatcacttac aagcactccc aataatccta ttaggtaggc     1560

actattatca ttcccatttt acagagtgga gaaccgaagc acactctcgg gagggcgggg     1620

tagctggctg cacccaggct gtgtagcctc agtccagatg taagggtggg tggaaaagag     1680

ccttgcccaa tgagggagaa cagtgaaacc aaggccatag ggtctaaaga ttcacgaacc     1740

aggctctcat ggagaaagca ggtgaggttt actgtataga tgggtgtgcc cctaccccac     1800

actgaggctt cctcgtctga gcaaactgag gcccagagag gggaaggaag caggactacc     1860

atggtgactc aaagaccagc tagaatccag cctcctctcc tcgaggcttc cactgcccca     1920

cgccaggcct gtgtgactca gtctagggcc tttccattac cccagctaaa cctttcttta     1980

gtcatttata ccatggtgtg aatggctggc tggtctttcc tgagagctat ctttgatgag     2040

gggagggagg catagccagg tttgggaagc tgatacccca ggaagcccag ttgactgtgt     2100

gggttatagc ccaggctgtc actgatttgt aacgggacct gagcaactct gcagagctag     2160

gcctcagtct tttcatctgc aaaatggata tagcagagat ggtcagagta ggtgacttcg     2220

aatgaccctt ccagctcact atgagtctgt tttcctgaac aaagagcatt ttttgtttaa     2280

aaaaaaattt cttgggccgg acacggtggt tcactcctat aatcctggca ctttgggagg     2340

ccgaggaggg tggatcgctt gagccaggag ttcaggacca gcctgggcaa catagcgaga     2400

ctccacccct acaaaaaata caaaaactag tggtgtgcac ttgtggtccc agctactcag     2460

gaggctgagg tgagaggatc gcttgagccc aggaggcaga ggctacagtg agctatgatt     2520

gtggcactgc actccagcct gggcgacaga gaccttgtct caaaactttt tttttcttcg     2580

tcaagcttta cagaataaag agcactgtca cctcagtgat ggctgttagt tccccatcac     2640

cagggctcca tgaggttgca attgtgaaac tcacaaagga ggaacctgag acagagaggg     2700

gaagtactga gatcatctag gtccattccc ccactcactc gttcattcaa caaatattca     2760

ggagcacctt ctaggtgcca ggccctggag acacatcagt gaacaaaaca gacatcatcc     2820

cacctctttc cactacaggc caagcaccat gctggtctct gggaaccctg ttgtgagcaa     2880

gacagaccca ggcttaccct tgtggactca tgttacaggc agggagacgg gcacaaaaca     2940

caaataaaaa gcttccatgc tgtcagaagc actatgcaaa aagcaagatg ctgaggtact     3000

gctaagctgt gtgggatggg ggctcagccc ggccagggag gggccagttg tgggtcagtc     3060

ttgacccaag gcatccagga caccctcctt ctggccatga gggtccacgt cagaatcaaa     3120

ccctcacctt aacctcatta gcgttgggca taatcaccag gccaagcgcc ttaaactacg     3180

agaggcccca tcccacccgc cctgccttag ccctgccacg tgtgccaaac gctgttagac     3240

ccaacaccac ccaggccagg tagggggctg gagcccaggt gggctgcagg gaagggggca     3300

ctcttctgag cagacagatc tgggaatcct gggtgggaag agagacagtg agagagagat     3360

taagggatat ttcccaggca tcagggcttt gcactctcag gggtccttcc gcctggatgt     3420

ccttcccctg aagcttcctc ctgttgttcc gttctcagct caagctccag cttctcagag     3480

aagcctcctg tgttgggagt ggctgcgact gaactgtccc tactgttatt cgctcttcta     3540

tttgtttgtg gtccctgtgc cccctcaccc cacaaaaaca ctggcttctt gtgagcagga     3600

gcttgctctt tcgtgtaccc tgtgtgtccc caaggaccaa gcaccttgtc tgggccacag     3660

taggtgctca atacacatgt tggctggaca gtggtcactg agcggccgca cgtcgggcac     3720

tctcagcact tgcacaggcc gccccagaca ccccacttca ttcctgggag gtgtcatcat     3780

gttgcttgga cgacggggag agggggacct gccagtgttg gcctccattt tcccccagtc     3840

atctgccccc aaggctctga ctactttctt tctcacggta catcctgcta ttctggaatc     3900

ggccctcgtg gggccacctg gtacatggca tttgaggccc tcgtggctga ttaggcctcc     3960

cccaacagtg ccctgtctgc tgcctccagg gccagcctcc ccttcagact ggagtcccct     4020

gaagggttct gcccctcccc tgctctggta gccccctcca tcctccctcc ctccactcca     4080

tctttggggg catttgagtc acctttctac accagtgatc tgcccaagcc actgctcact     4140

ttcctctgga taaagccagg ttccccggcc tagcgttcaa gacccattac aactgccccc     4200

agcccagatc ttccccacct agccacctgg caaactgctc cttctctcaa aggcccaaac     4260

atggcctccc agactgcaac ccccaggcag tcaggccctg tctccacaac ctcacagcca     4320

ccctggacgg aatctgcttc ttcccacatt tgagtcctcc tcagcccctg agctcctctg     4380

ggcagggctg tttctttcca tctttgtatt cccaggggcc tgcaaataaa tgtttaatga     4440

acgaacaaga gagtgaattc caattccatg caacaaggat tgggctcctg ggccctaggc     4500

tatgtgtctg gcaccagaaa cggaagctgc aggttgcagc ccctgccctc atggagctcc     4560

tcctgtcaga ggagtgtggg gactggatga ctccagaggt aacttgtggg ggaacgaaca     4620

ggtaaggggc tgtgtgacga gatgagagac tgggagaata aaccagaaag tctctagctg     4680

tccagaggac atagcacaga ggcccatggt ccctatttca aacccaggcc accagactga     4740

gctgggacct tgggacagac aagtcatgca gaagttaggg gaccttctcc tcccttttcc     4800

tggatcctga gtacctctcc tccctgacct caggcttcct cctagtgtca ccttggcccc     4860

tcttagaagc caattaggcc ctcagtttct gcagcgggga ttaatatgat tatgaacacc     4920

cccaatctcc cagatgctga ttcagccagg agcttaggag ggggaggtca ctttataagg     4980

gtctgggggg gtcagaaccc agagtcatcc agctggagcc ctgagtggct gagctcaggc     5040

cttcgcagca ttcttgggtg ggagcagcca cgggtcagcc acaagggcca cagccatgaa     5100

tggcacagaa ggccctaact tctacgtgcc cttctccaat gcgacgggtg tggtacgcag     5160

ccacttcgag tacccacagt actacctggc tgagccatgg cagttctcca tgctggccgc     5220

ctacatgttt ctgctgatcg tgctgggctt ccccatcaac ttcctcacgc tctacgtcac     5280

cgtccagcac aagaagctgc gcacgcctct caactacatc ctgctcaacc tagccgtggc     5340

tgacctcttc atggtcctag gtggcttcac cagcaccctc tacacctctc tgcatggata     5400

cttcgtcttc gggcccacag gatgcaattt ggagggcttc tttgccaccc tgggcggtat     5460

gagccgggtg tgggtggggt gtgcaggagc ccgggagcat ggaggggtct gggagagtcc     5520

cgggcttggc ggtggtggct gagaggcctt ctcccttctc ctgtcctgtc aatgttatcc     5580

aaagccctca tatattcagt caacaaacac cattcatggt gatagccggg ctgctgtttg     5640

tgcagggctg gcactgaaca ctgccttgat cttatttgga gcaatatgcg cttgtctaat     5700

ttcacagcaa gaaaactgag ctgaggctca aagaagtcaa gcgccctgct ggggcgtcac     5760

acagggacgg gtgcagagtt gagttggaag cccgcatcta tctcgggcca tgtttgcagc     5820

accaagcctc tgtttccctt ggagcagctg tgctgagtca gacccaggct gggcactgag     5880

ggagagctgg gcaagccaga cccctcctct ctgggggccc aagctcaggg tgggaagtgg     5940

attttccatt ctccagtcat tgggtcttcc ctgtgctggg caatgggctc ggtcccctct     6000

ggcatcctct gcctcccctc tcagcccctg tcctcaggtg cccctccagc ctccctgccg     6060

cgttccaagt ctcctggtgt tgagaaccgc aagcagccgc tctgaagcag ttcctttttg     6120

ctttagaata atgtcttgca tttaacagga aaacagatgg ggtgctgcag ggataacaga     6180

tcccacttaa cagagaggaa aactgaggca gggagagggg aagagactca tttagggatg     6240

tggccaggca gcaacaagag cctaggtctc ctggctgtga tccaggaata tctctgctga     6300

gatgcaggag gagacgctag aagcagccat tgcaaagctg ggtgacgggg agagcttacc     6360

gccagccaca agcgtctctc tgccagcctt gccctgtctc ccccatgtcc aggctgctgc     6420

ctcggtccca ttctcaggga atctctggcc attgttgggt gtttgttgca ttcaataatc     6480

acagatcact cagttctggc cagaaggtgg gtgtgccact tacgggtggt tgttctctgc     6540

agggtcagtc ccagtttaca aatattgtcc ctttcactgt taggaatgtc ccagtttggt     6600

tgattaacta tatggccact ctccctatgg aacttcatgg ggtggtgagc aggacagatg     6660

tctgaattcc atcatttcct tcttcttcct ctgggcaaaa cattgcacat tgcttcatgg     6720

ctcctaggag aggcccccac atgtccgggt tatttcattt cccgagaagg gagagggagg     6780

aaggactgcc aattctgggt ttccaccacc tctgcattcc ttcccaacaa ggaactctgc     6840

cccacattag gatgcattct tctgctaaac acacacacac acacacacac acacaacaca     6900

cacacacaca cacacacaca cacacacaca aaactcccta ccgggttccc agttcaatcc     6960

tgaccccctg atctgattcg tgtcccttat gggcccagag cgctaagcaa ataacttccc     7020

ccattccctg gaatttcttt gcccagctct cctcagcgtg tggtccctct gccccttccc     7080

cctcctccca gcaccaagct ctctccttcc ccaaggcctc ctcaaatccc tctcccactc     7140

ctggttgcct tcctagctac cctctccctg tctagggggg agtgcaccct ccttaggcag     7200

tggggtctgt gctgaccgcc tgctgactgc cttgcaggtg aaattgccct gtggtccttg     7260

gtggtcctgg ccatcgagcg gtacgtggtg gtgtgtaagc ccatgagcaa cttccgcttc     7320

ggggagaacc atgccatcat gggcgttgcc ttcacctggg tcatggcgct ggcctgcgcc     7380

gcacccccac tcgccggctg gtccaggtaa tggcactgag cagaagggaa gaagctccgg     7440

gggctctttg tagggtcctc cagtcaggac tcaaacccag tagtgtctgg ttccaggcac     7500

tgaccttgta tgtctcctgg cccaaatgcc cactcagggt aggggtgtag ggcagaagaa     7560

gaaacagact ctaatgttgc tacaagggct ggtcccatct cctgagcccc atgtcaaaca     7620

gaatccaaga catcccaacc cttcaccttg gctgtgcccc taatcctcaa ctaagctagg     7680

cgcaaattcc aatcctcttt ggtctagtac cccgggggca gccccctcta accttgggcc     7740

tcagcagcag gggaggccac accttcctag tgcaggtggc catattgtgg ccccttggaa     7800

ctgggtccca ctcagcctct aggcgattgt ctcctaatgg ggctgagatg agacacagtg     7860

gggacagtgg tttggacaat aggactggtg actctggtcc ccagaggcct catgtccctc     7920

tgtctccaga aaattcccac tctcacttcc ctttcctcct cagtcttgct agggtccatt     7980

tcttacccct tgctgaattt gagcccaccc cctggacttt ttccccatct tctccaatct     8040

ggcctagttc tatcctctgg aagcagagcc gctggacgct ctgggtttcc tgaggcccgt     8100

ccactgtcac caatatcagg aaccattgcc acgtcctaat gacgtgcgct ggaagcctct     8160

agtttccaga agctgcacaa agatccctta gatactctgt gtgtccatct ttggcctgga     8220

aaatactctc accctggggc taggaagacc tcggtttgta caaacttcct caaatgcaga     8280

gcctgagggc tctccccacc tcctcaccaa ccctctgcgt ggcatagccc tagcctcagc     8340

gggcagtgga tgctggggct gggcatgcag ggagaggctg ggtggtgtca tctggtaacg     8400

cagccaccaa acaatgaagc gacactgatt ccacaaggtg catctgcatc cccatctgat     8460

ccattccatc ctgtcaccca gccatgcaga cgtttatgat ccccttttcc agggagggaa     8520

tgtgaagccc cagaaagggc cagcgctcgg cagccacctt ggctgttccc aagtccctca     8580

caggcagggt ctccctacct gcctgtcctc aggtacatcc ccgagggcct gcagtgctcg     8640

tgtggaatcg actactacac gctcaagccg gaggtcaaca acgagtcttt tgtcatctac     8700

atgttcgtgg tccacttcac catccccatg attatcatct ttttctgcta tgggcagctc     8760

gtcttcaccg tcaaggaggt acgggccggg gggtgggcgg cctcacggct ctgagggtcc     8820

agcccccagc atgcatctgc ggctcctgct ccctggagga gccatggtct ggacccgggt     8880

cccgtgtcct gcaggccgct gcccagcagc aggagtcagc caccacacag aaggcagaga     8940

aggaggtcac ccgcatggtc atcatcatgg tcatcgcttt cctgatctgc tgggtgccct     9000

acgccagcgt ggcattctac atcttcaccc accagggctc caacttcggt cccatcttca     9060

tgaccatccc agcgttcttt gccaagagcg ccgccatcta caaccctgtc atctatatca     9120

tgatgaacaa gcaggtgcct actgcgggtg ggagggcccc agtgccccag gccacaggcg     9180

ctgcctgcca aggacaagct acttcccagg gcaggggagg gggctccatc agggttactg     9240

gcagcagtct tgggtcagca gtcccaatgg ggagtgtgtg agaaatgcag attcctggcc     9300

ccactcagaa ctgctgaatc tcagggtggg cccaggaacc tgcatttcca gcaagccctc     9360

cacaggtggc tcagatgctc actcaggtgg gagaagctcc agtcagctag ttctggaagc     9420

ccaatgtcaa agtcagaagg acccaagtcg ggaatgggat gggccagtct ccataaagct     9480

gaataaggag ctaaaaagtc ttattctgag gggtaaaggg gtaaagggtt cctcggagag     9540

gtacctccga ggggtaaaca gttgggtaaa cagtctctga agtcagctct gccattttct     9600

agctgtatgg ccctgggcaa gtcaatttcc ttctctgtgc tttggtttcc tcatccatag     9660

aaaggtagaa agggcaaaac accaaactct tggattacaa gagataattt acagaacacc     9720

cttggcacac agagggcacc atgaaatgtc acgggtgaca cagccccctt gtgctcagtc     9780

cctggcatct ctaggggtga ggagcgtctg cctagcaggt tccctccagg aagctggatt     9840

tgagtggatg gggcgctgga atcgtgaggg gcagaagcag gcaaagggtc ggggcgaacc     9900

tcactaacgt gccagttcca agcacactgt gggcagccct ggccctgact caagcctctt     9960

gccttccagt tccggaactg catgctcacc accatctgct gcggcaagaa cccactgggt    10020

gacgatgagg cctctgctac cgtgtccaag acggagacga gccaggtggc cccggcctaa    10080

gacctgccta ggactctgtg gccgactata ggcgtctccc atcccctaca ccttccccca    10140

gccacagcca tcccaccagg agcagcgcct gtgcagaatg aacgaagtca cataggctcc    10200

ttaatttttt tttttttttt aagaaataat taatgaggct cctcactcac ctgggacagc    10260

ctgagaaggg acatccacca agacctactg atctggagtc ccacgttccc caaggccagc    10320

gggatgtgtg cccctcctcc tcccaactca tctttcagga acacgaggat tcttgctttc    10380

tggaaaagtg tcccagctta gggataagtg tctagcacag aatggggcac acagtaggtg    10440

cttaataaat gctggatgga tgcaggaagg aatggaggaa tgaatgggaa gggagaacat    10500

atctatcctc tcagaccctc gcagcagcag caactcatac ttggctaatg atatggagca    10560

gttgtttttc cctccctggg cctcactttc ttctcctata aaatggaaat cccagatccc    10620

tggtcctgcc gacacgcagc tactgagaag accaaaagag gtgtgtgtgt gtctatgtgt    10680

gtgtttcagc actttgtaaa tagcaagaag ctgtacagat tctagttaat gttgtgaata    10740

acatcaatta atgtaactag ttaattacta tgattatcac ctcctgatag tgaacatttt    10800

gagattgggc attcagatga tggggtttca cccaaccttg gggcaggttt ttaaaaatta    10860

gctaggcatc aaggccagac cagggctggg ggttgggctg taggcaggga cagtcacagg    10920

aatgcagaat gcagtcatca gacctgaaaa aacaacactg ggggaggggg acggtgaagg    10980

ccaagttccc aatgagggtg agattgggcc tggggtctca cccctagtgt ggggccccag    11040

gtcccgtgcc tccccttccc aatgtggcct atggagagac aggcctttct ctcagcctct    11100

ggaagccacc tgctcttttg ctctagcacc tgggtcccag catctagagc atggagcctc    11160

tagaagccat gctcacccgc ccacatttaa ttaacagctg agtccctgat gtcatcctta    11220

tctcgaagag cttagaaaca aagagtggga aattccactg ggcctacctt ccttggggat    11280

gttcatgggc cccagtttcc agtttccctt gccagacaag cccatcttca gcagttgcta    11340

gtccattctc cattctggag aatctgctcc aaaaagctgg ccacatctct gaggtgtcag    11400

aattaagctg cctcagtaac tgctccccct tctccatata agcaaagcca gaagctctag    11460

ctttacccag ctctgcctgg agactaaggc aaattgggcc attaaaagct cagctcctat    11520

gttggtatta acggtggtgg gttttgttgc tttcacactc tatccacagg atagattgaa    11580

actgccagct tccacctgat ccctgaccct gggatggctg gattgagcaa tgagcagagc    11640

caagcagcac agagtcccct ggggctagag gtggaggagg cagtcctggg aatgggaaaa    11700

accccaactt tggggtcata gaggcacagg taacccataa aactgcaaac aagctttgtc    11760

acctctcaga gcttccttat ctgcaaaaaa gaatcttaaa actgaccttg gctgggcaca    11820

gtggctcaca cctctaatcc cagcactttg ggaggccaag gtgggcagat cacgaggtca    11880

ggagtttgag accagcctga ccaacacggt gaaaccctgt ctctactaaa aatacaaaaa    11940

tcagctgggc atggtggcgc gtgcctgtaa tcccagctat tcagtgggct gaggcaggag    12000

aatcgcttga acctgggagg tggaggttgc agtgagccga gattgcgcca ctgcactcca    12060

gcctgagcaa cagagggaca gtctgtctcc aaacaaaaca aaacaaacaa acaaacaaac    12120

aaacaaacaa aaaacaacaa caaaaaaacc acttgatcct aaggggatta gatgcgactg    12180

tggactttaa gtggccagcc tactgcctgg catgcagcag atgagactat ggcaatactg    12240

ggcttcagct cagagctggc cttactagag accctgtccc aaaggggaaa aggatggagc    12300

taaagctccc gagagtcacc ccctcctccg aggtgagaaa ggagggcagg agcatgagat    12360

agccgatcct cggtgccttg gtgaggctgg ggcaaatcat gctgggatct ctatcattgt    12420

ccctctttac tgtgactcac tagataatat cagtcaggat acttttggtc acaagtgata    12480

ggaaatccaa ctcatttggg ctgaagcaaa agggacacat tgttggctca catgaacaaa    12540

aagcccgggg cttcaggcac agggtatcac catgactgag atggggatta attctgtgat    12600

tggccaagtc taggtcacct gatcatacgt aactcattta tgcctgaggt tgcaattttt    12660

tggatttttg caatcagacc ttggcgatga ccttgagcag taggatataa ataactccca    12720

catgcttagc gttccaataa tggaatacta ggcatacgca ggtctaactg catcaccatg    12780

gctggaatgg ggattcatcc tctgattggt cagacctagg tcacatgctc accctgcagc    12840

ccaagcaggc tgaatgggga gaggtaggtt tcacaaagga aagcccaggt gctgttacct    12900

gaagtaggag ggcaggaggc agggtgagca gagccaacat caacccagag ggaatggaat    12960

ctaagttggt gttttctggg cacgtggctg gaccaggcct ccctccctca tcatctcagg    13020

gacatgaggg agaagattcc tatgggtggt cccgaaggtc tcaccctttg ttttggatgc    13080

tgtgttgggc cagggtggca gtgggtggga cagtggcatc ttagctgccc tgacttgcag    13140

gcagcccatt ccagctcccc gccccaaccc caacccagcc cactttttct gagaaatggt    13200

acatttgccc cagcctcatg tccagaggaa aattttactc taacaccaga acattctctg    13260

gtttgtcctg atagacaaga aagcctccac ctccttaatt tacaaatgac ttgacagctg    13320

cttcgtgggc acttgcatac ataaagagaa ggagctgctg ccttaagttg cagcaagttt    13380

ggccccacct catctccagg cagccagcag atgtacagag tgcctcttgg gtacaatggc    13440

agctccattc aaccaaacct gagcaagctg accccatgcc agaatgcact ggggactcgg    13500

agatgaattg gagcctagag accaagtctc taggctatga cctgggctgc ctcacggcca    13560

cagagctctg tcacgccaag ggagagatgc acccctgaaa gcctgaggtg ccccataagg    13620

agagagtggg tgcccttccc aactatgtag cttcagggca agttctcttt ctttcttttt    13680

ctttctttct ctttctttct ttcttt                                         13706


<210>  5
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  6
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser His Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  7
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  7
acgggtgtgg tacgcagcca ct                                                22


<210>  8
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  8
tgcccacacc atgcgtcggt ga                                                22


<210>  9
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  9
acgggtgtgg tacgcagccc ct                                                22


<210>  10
<211>  22
<212>  DNA
<213>  Homo sapiens

<400>  10
tgcccacacc atgcgtcggg ga                                                22


<210>  11
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  11

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Phe Ala Arg Ile Phe Lys Gly Gln His 
            20                  25                  30          


Trp Lys Phe Lys His Tyr Ile Arg Leu Thr Phe Ser Val Arg Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Val Asp Ser Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Trp Ala Ser Ile Ile Pro Glu Gln Arg Leu 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Val Asp Gln Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  12
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  12

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Phe Ala Arg Ile Phe Lys Gly Gln His 
            20                  25                  30          


Trp Lys Phe Lys His Tyr Ile Arg Leu Thr Phe Ser Val Arg Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Cys Asp Ser Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Trp Ala Ser Ile Ile Pro Glu Gln Asn Gly 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Val Asp Gln Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  13
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  13

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Tyr Ala Arg Ile Phe Lys Gly Gln His 
            20                  25                  30          


Trp Lys Phe Lys His Tyr Ile Arg Leu Thr Phe Ser Val Arg Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Gln Asp Ser Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Trp Ala Ser Ile Ile Pro Glu Gln Ala Tyr 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Val Asp Gln Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  14
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  14

Met Asn Thr Lys Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe 
1               5                   10                  15      


Val Asp Gly Asp Gly Ser Ile Phe Ala Arg Ile Phe Lys Gly Gln His 
            20                  25                  30          


Trp Lys Phe Lys His Tyr Ile Arg Leu Thr Phe Ser Val Arg Gln Lys 
        35                  40                  45              


Thr Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val 
    50                  55                  60                  


Gly Tyr Val Tyr Asp Ser Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu 
65                  70                  75                  80  


Ile Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys 
                85                  90                  95      


Leu Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu 
            100                 105                 110         


Pro Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp 
        115                 120                 125             


Val Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr 
    130                 135                 140                 


Ser Glu Thr Val Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly 
145                 150                 155                 160 


Gly Leu Ser Pro Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser 
                165                 170                 175     


Ser Pro Gly Ser Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser 
            180                 185                 190         


Gly Thr Gly Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val 
        195                 200                 205             


Asp Gly Asp Gly Ser Ile Trp Ala Ser Ile Ile Pro Glu Gln Lys Ser 
    210                 215                 220                 


Lys Phe Lys His Arg Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr 
225                 230                 235                 240 


Gln Arg Arg Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly 
                245                 250                 255     


Tyr Val Val Asp Gln Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile 
            260                 265                 270         


Lys Pro Leu His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu 
        275                 280                 285             


Lys Gln Lys Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro 
    290                 295                 300                 


Ser Ala Lys Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val 
305                 310                 315                 320 


Asp Gln Ile Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser 
                325                 330                 335     


Glu Thr Val Arg Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser 
            340                 345                 350         


Ser Pro 
        


<210>  15
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  15

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Trp Ala Ser Ile Ile Pro Glu Gln Arg Leu Lys Phe Lys His Arg 
            20                  25                  30          


Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Val Asp Gln 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  16
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  16

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Trp Ala Ser Ile Ile Pro Glu Gln Asn Gly Lys Phe Lys His Arg 
            20                  25                  30          


Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Val Asp Gln 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  17
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  17

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Trp Ala Ser Ile Ile Pro Glu Gln Ala Tyr Lys Phe Lys His Arg 
            20                  25                  30          


Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Val Asp Gln 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  18
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  18

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Trp Ala Ser Ile Ile Pro Glu Gln Lys Ser Lys Phe Lys His Arg 
            20                  25                  30          


Leu Arg Leu Ser Phe Thr Val Ala Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Val Asp Gln 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Arg Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  19
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  19

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Phe Lys Gly Gln His Trp Lys Phe Lys His Tyr 
            20                  25                  30          


Ile Arg Leu Thr Phe Ser Val Arg Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Val Asp Ser 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  20
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  20

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Phe Lys Gly Gln His Trp Lys Phe Lys His Tyr 
            20                  25                  30          


Ile Arg Leu Thr Phe Ser Val Arg Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Cys Asp Ser 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  21
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  21

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Tyr Ala Arg Ile Phe Lys Gly Gln His Trp Lys Phe Lys His Tyr 
            20                  25                  30          


Ile Arg Leu Thr Phe Ser Val Arg Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Gln Asp Ser 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  22
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  22

Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
1               5                   10                  15      


Ile Phe Ala Arg Ile Phe Lys Gly Gln His Trp Lys Phe Lys His Tyr 
            20                  25                  30          


Ile Arg Leu Thr Phe Ser Val Arg Gln Lys Thr Gln Arg Arg Trp Phe 
        35                  40                  45              


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Ser 
    50                  55                  60                  


Gly Ser Val Ser Glu Tyr Tyr Leu Ser Glu Ile Lys Pro Leu His Asn 
65                  70                  75                  80  


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
                85                  90                  95      


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
            100                 105                 110         


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
        115                 120                 125             


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
    130                 135                 140                 


Val Leu Asp 
145         


<210>  23
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  23
ccgggcgaag ggtgtggtga gtggccactt g                                      31


<210>  24
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  24
ggcccgcttc ccacaccact caccggtgaa c                                      31


<210>  25
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  25
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacggtgac       60

ggttccatct ttgcccgtat ctttaagggt caacattgga agttcaagca ctatattcgt      120

ttgaccttct cggtgcggca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt ggttgactct ggcagcgttt ccgagtacta cctgtccgag      240

attaaaccat tacataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctgggcctc gatcattcct      660

gagcaacggc ttaaattcaa gcataggctg cgcctctctt tcactgtcgc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtggttgac      780

cagggcagcg tctccgagta taggctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  26
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  26
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacggtgac       60

ggttccatct ttgcccgtat ctttaagggt caacattgga agttcaagca ctatattcgt      120

ttgaccttca gtgtgcggca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtgtgactct ggcagcgttt ccgagtacta cctgtccgag      240

attaaaccat tacataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctgggcctc gatcattcct      660

gagcaaaatg gtaaattcaa gcataggctg cgcctctctt tcactgtcgc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtggttgac      780

cagggcagcg tctccgagta taggctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  27
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  27
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacggtgac       60

ggttccatct atgcccgtat ctttaagggt caacattgga agttcaagca ctatattcgt      120

ttgaccttca gtgtgcggca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gcaggactct ggcagcgttt ccgagtacta cctgtccgag      240

attaaaccat tacataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctgggcctc gatcattcct      660

gagcaagcgt ataaattcaa gcataggctg cgcctctctt tcactgtcgc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtggttgac      780

cagggcagcg tctccgagta taggctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  28
<211>  1062
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  28
atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt agacggtgac       60

ggttccatct ttgcccgtat ctttaagggt caacattgga agttcaagca ctatattcgt      120

ttgaccttct cggtgcggca gaagacacag cgccgttggt tcctcgacaa gctggtggac      180

gagatcggtg tgggttacgt gtatgactct ggcagcgttt ccgagtacta cctgtccgag      240

attaaaccat tacataattt tttaacacaa ctacaacctt ttctaaaact aaaacaaaaa      300

caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga atccccggac      360

aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga ttcgaagacg      420

cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg atccgtggga      480

ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag cccgggttca      540

gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa caaggaattc      600

ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctgggcctc gatcattcct      660

gagcaaaagt cgaaattcaa gcataggctg cgcctctctt tcactgtcgc tcagaagaca      720

cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta cgtggttgac      780

cagggcagcg tctccgagta taggctgtcc gagatcaagc ctctgcacaa cttcctgacc      840

cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct gaagatcatc      900

gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg cacctgggtg      960

gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga aaccgtccgc     1020

gccgttctag acagtctctc cgagaagaag aagtcgtccc cc                        1062


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthesized

<400>  29

Met Ala Pro Lys Lys Lys Arg Lys Val His 
1               5                   10  


