                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Incorporated
 
<120>  DISEASE CORRECTION BY DELIVERY OF AAV8 VECTORS EXPRESSING CODON 
       OPTIMIZED NAGLU

<130>  U1196.70068WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/023,224
<151>  2020-05-11

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  2264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
atggaggctg tggctgtggc tgccgctgtg ggagtgctgc tgctggctgg ggccggaggg       60

gccgctggcg atgaggctcg ggaggctgca gctgtgcgcg cactggtcgc acgactgctg      120

ggacctgggc cagcagccga cttctctgtg agtgtcgaga gagccctggc tgcaaagccc      180

ggactggata cctacagtct gggaggagga ggagcagctc gagtgagggt cagagggtca      240

acaggagtgg cagcagctgc aggactgcac cgatatctgc gagacttttg cggctgtcat      300

gtggcctggt caggaagcca gctgaggctg cccagacctc tgccagcagt gccaggcgag      360

ctgacagaag ccactcccaa ccggtaccgc tactatcaga acgtgtgcac ccagtcctat      420

tctttcgtct ggtgggactg ggctcgatgg gagcgcgaaa tcgattggat ggcactgaac      480

ggaattaatc tggcactggc atggtccgga caggaggcaa tctggcagag agtgtacctg      540

gcactgggac tgactcaggc cgagattaac gagttcttca ccgggccagc ttttctggca      600

tggggacgga tggggaatct gcacacatgg gacggaccac tgccaccttc ttggcacatc      660

aaacagctgt atctgcagca tagggtgctg gatcagatga gaagttttgg catgactcca      720

gtgctgcccg ctttcgcagg acacgtccct gaggccgtga cacgcgtctt cccacaggtg      780

aacgtcacta agatgggcag ctggggacac ttcaactgca gttactcatg tagcttcctg      840

ctggcccctg aagatccaat ttttcccatc attggaagcc tgttcctgcg ggagctgatc      900

aaagaatttg gaaccgacca catctacggg gccgatacat tcaacgagat gcagccaccc      960

agctccgaac ctagctacct ggccgctgca accacagccg tgtacgaggc catgaccgct     1020

gtggacacag aagccgtctg gctgctgcag gggtggctgt ttcagcatca gccacagttc     1080

tggggacctg cacagatccg agctgtgctg ggagcagtcc cacgaggaag gctgctggtg     1140

ctggatctgt tcgctgagtc ccagcccgtc tacactagga ccgcctcttt ccagggccag     1200

ccttttattt ggtgtatgct gcacaacttt ggagggaatc atgggctgtt cggcgcactg     1260

gaggcagtga acggaggacc agaagcagct agactgtttc ctaatagcac tatggtgggc     1320

accggaatgg ctcccgaggg catctcacag aatgaagtgg tctacagcct gatggcagag     1380

ctgggatggc gaaaggaccc cgtgcctgat ctggcagcct gggtcactag tttcgctgca     1440

aggagatacg gggtgtcaca ccctgacgct ggagcagctt ggcgactgct gctgaggagc     1500

gtgtacaact gcagtgggga ggcctgtaga ggccataatc ggtccccact ggtgcggcgc     1560

ccctcactgc agatgaacac cagcatctgg tacaatcgat ccgacgtgtt cgaagcttgg     1620

cggctgctgc tgacaagtgc cccttcactg gctacttctc cagcattccg ctatgacctg     1680

ctggatctga caaggcaggc cgtgcaggag ctggtcagcc tgtactatga ggaagctcgc     1740

agcgcatacc tgtccaagga actggcatcc ctgctgaggg caggaggcgt gctggcttat     1800

gagctgctgc cagctctgga cgaagtcctg gcatccgatt ctagatttct gctgggcagc     1860

tggctggagc aggcacgagc agcagccgtg agcgaggccg aagctgactt ctacgagcag     1920

aactctaggt atcagctgac tctgtgggga cccgaaggga acatcctgga ttacgcaaac     1980

aagcagctgg caggactggt ggctaattac tataccccta gatggcggct gtttctggag     2040

gccctggtgg actctgtcgc tcagggcatt ccattccagc agcaccagtt tgataagaac     2100

gtgttccagc tggaacaggc cttcgtcctg tctaaacagc ggtatcctag tcagccacgc     2160

ggcgacacag tggacctggc aaagaagatt ttcctgaaat actatccccg ctgggtggct     2220

ggctcatgga ccggtggcgc gccttcgaac tgcagctcga ggta                      2264


<210>  2
<211>  4533
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctcagat ctgaattcgg tacctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggagtattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcgc gctgccttcg ccccgtgccc      840

cgctccgccg ccgcctcgcg ccgcccgccc cggctctgac tgaccgcgtt actcccacag      900

gtgagcgggc gggacggccc ttctcctccg ggctgtaatt agcgcttggt ttaatgacgg      960

cttgtttctt ttctgtggct gcgtgaaagc cttgaggggc tccgggaggg ccctttgtgc     1020

ggggggagcg gctcgggggg tgcgtgcgtg tgtgtgtgcg tggggagcgc cgcgtgcggc     1080

tccgcgctgc ccggcggctg tgagcgctgc gggcgcggcg cggggctttg tgcgctccgc     1140

agtgtgcgcg aggggagcgc ggccgggggc ggtgccccgc ggtgcggggg gggctgcgag     1200

gggaacaaag gctgcgtgcg gggtgtgtgc gtgggggggt gagcaggggg tgtgggcgcg     1260

tcggtcgggc tgcaaccccc cctgcacccc cctccccgag ttgctgagca cggcccggct     1320

tcgggtgcgg ggctccgtac ggggcgtggc gcggggctcg ccgtgccggg cggggggtgg     1380

cggcaggtgg gggtgccggg cggggcgggg ccgcctcggg ccggggaggg ctcgggggag     1440

gggcgcggcg gcccccggag cgccggcggc tgtcgaggcg cggcgagccg cagccattgc     1500

cttttatggt aatcgtgcga gagggcgcag ggacttcctt tgtcccaaat ctgtgcggag     1560

ccgaaatctg ggaggcgccg ccgcaccccc tctagcgggc gcggggcgaa gcggtgcggc     1620

gccggcagga aggaaatggg cggggagggc cttcgtgcgt cgccgcgccg ccgtcccctt     1680

ctccctctcc agcctcgggg ctgtccgcgg ggggacggct gccttcgggg gggacggggc     1740

agggcggggt tcggcttctg gcgtgtgacc ggcggctcta gagcctctgc taaccatgtt     1800

catgccttct tctttttcct acagctcctg ggcaacgtgc tggttattgt gctgtctcat     1860

cattttggca aagaattcct cgaagatcta ggcctgcagg cggccgccac catggaggct     1920

gtggctgtgg ctgccgctgt gggagtgctg ctgctggctg gggccggagg ggccgctggc     1980

gatgaggctc gggaggctgc agctgtgcgc gcactggtcg cacgactgct gggacctggg     2040

ccagcagccg acttctctgt gagtgtcgag agagccctgg ctgcaaagcc cggactggat     2100

acctacagtc tgggaggagg aggagcagct cgagtgaggg tcagagggtc aacaggagtg     2160

gcagcagctg caggactgca ccgatatctg cgagactttt gcggctgtca tgtggcctgg     2220

tcaggaagcc agctgaggct gcccagacct ctgccagcag tgccaggcga gctgacagaa     2280

gccactccca accggtaccg ctactatcag aacgtgtgca cccagtccta ttctttcgtc     2340

tggtgggact gggctcgatg ggagcgcgaa atcgattgga tggcactgaa cggaattaat     2400

ctggcactgg catggtccgg acaggaggca atctggcaga gagtgtacct ggcactggga     2460

ctgactcagg ccgagattaa cgagttcttc accgggccag cttttctggc atggggacgg     2520

atggggaatc tgcacacatg ggacggacca ctgccacctt cttggcacat caaacagctg     2580

tatctgcagc atagggtgct ggatcagatg agaagttttg gcatgactcc agtgctgccc     2640

gctttcgcag gacacgtccc tgaggccgtg acacgcgtct tcccacaggt gaacgtcact     2700

aagatgggca gctggggaca cttcaactgc agttactcat gtagcttcct gctggcccct     2760

gaagatccaa tttttcccat cattggaagc ctgttcctgc gggagctgat caaagaattt     2820

ggaaccgacc acatctacgg ggccgataca ttcaacgaga tgcagccacc cagctccgaa     2880

cctagctacc tggccgctgc aaccacagcc gtgtacgagg ccatgaccgc tgtggacaca     2940

gaagccgtct ggctgctgca ggggtggctg tttcagcatc agccacagtt ctggggacct     3000

gcacagatcc gagctgtgct gggagcagtc ccacgaggaa ggctgctggt gctggatctg     3060

ttcgctgagt cccagcccgt ctacactagg accgcctctt tccagggcca gccttttatt     3120

tggtgtatgc tgcacaactt tggagggaat catgggctgt tcggcgcact ggaggcagtg     3180

aacggaggac cagaagcagc tagactgttt cctaatagca ctatggtggg caccggaatg     3240

gctcccgagg gcatctcaca gaatgaagtg gtctacagcc tgatggcaga gctgggatgg     3300

cgaaaggacc ccgtgcctga tctggcagcc tgggtcacta gtttcgctgc aaggagatac     3360

ggggtgtcac accctgacgc tggagcagct tggcgactgc tgctgaggag cgtgtacaac     3420

tgcagtgggg aggcctgtag aggccataat cggtccccac tggtgcggcg cccctcactg     3480

cagatgaaca ccagcatctg gtacaatcga tccgacgtgt tcgaagcttg gcggctgctg     3540

ctgacaagtg ccccttcact ggctacttct ccagcattcc gctatgacct gctggatctg     3600

acaaggcagg ccgtgcagga gctggtcagc ctgtactatg aggaagctcg cagcgcatac     3660

ctgtccaagg aactggcatc cctgctgagg gcaggaggcg tgctggctta tgagctgctg     3720

ccagctctgg acgaagtcct ggcatccgat tctagatttc tgctgggcag ctggctggag     3780

caggcacgag cagcagccgt gagcgaggcc gaagctgact tctacgagca gaactctagg     3840

tatcagctga ctctgtgggg acccgaaggg aacatcctgg attacgcaaa caagcagctg     3900

gcaggactgg tggctaatta ctatacccct agatggcggc tgtttctgga ggccctggtg     3960

gactctgtcg ctcagggcat tccattccag cagcaccagt ttgataagaa cgtgttccag     4020

ctggaacagg ccttcgtcct gtctaaacag cggtatccta gtcagccacg cggcgacaca     4080

gtggacctgg caaagaagat tttcctgaaa tactatcccc gctgggtggc tggctcatgg     4140

taagtcgact agagctcgct gatcagcctc gactgtgcct tctagttgcc agccatctgt     4200

tgtttgcccc tcccccgtgc cttccttgac cctggaaggt gccactccca ctgtcctttc     4260

ctaataaaat gaggaaattg catcgcattg tctgagtagg tgtcattcta ttctgggggg     4320

tggggtgggg caggacagca agggggagga ttgggaagac aatagcaggc atgctgggga     4380

gagatctgag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     4440

cactgaggcc gcccgggcaa agcccgggcg tcgggcgacc tttggtcgcc cggcctcagt     4500

gagcgagcga gcgcgcagag agggagtggc caa                                  4533


<210>  3
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Phe Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Val Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Phe Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  4
<211>  145
<212>  DNA
<213>  adeno-associated virus 2

<400>  4
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcct                                            145


<210>  5
<211>  6838
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5
gggggggggg ggggggggtt ggccactccc tctctgcgcg ctcgctcgct cactgaggcc       60

gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt gagcgagcga      120

gcgcgcagag agggagtggc caactccatc actaggggtt cctagatctg aattcggtac      180

cctagttatt aatagtaatc aattacgggg tcattagttc atagcccata tatggagttc      240

cgcgttacat aacttacggt aaatggcccg cctggctgac cgcccaacga cccccgccca      300

ttgacgtcaa taatgacgta tgttcccata gtaacgccaa tagggacttt ccattgacgt      360

caatgggtgg actatttacg gtaaactgcc cacttggcag tacatcaagt gtatcatatg      420

ccaagtacgc cccctattga cgtcaatgac ggtaaatggc ccgcctggca ttatgcccag      480

tacatgacct tatgggactt tcctacttgg cagtacatct acgtattagt catcgctatt      540

accatggtcg aggtgagccc cacgttctgc ttcactctcc ccatctcccc cccctcccca      600

cccccaattt tgtatttatt tattttttaa ttattttgtg cagcgatggg ggcggggggg      660

gggggggggc gcgcgccagg cggggcgggg cggggcgagg ggcggggcgg ggcgaggcgg      720

agaggtgcgg cggcagccaa tcagagcggc gcgctccgaa agtttccttt tatggcgagg      780

cggcggcggc ggcggcccta taaaaagcga agcgcgcggc gggcgggagt cgctgcgacg      840

ctgccttcgc cccgtgcccc gctccgccgc cgcctcgcgc cgcccgcccc ggctctgact      900

gaccgcgtta ctcccacagg tgagcgggcg ggacggccct tctcctccgg gctgtaatta      960

gcgcttggtt taatgacggc ttgtttcttt tctgtggctg cgtgaaagcc ttgaggggct     1020

ccgggagcta gagcctctgc taaccatgtt catgccttct tctttttcct acagctcctg     1080

ggcaacgtgc tggttattgt gctgtctcat cattttggca aagaattcat ggaggctgtg     1140

gctgtggctg ccgctgtggg agtgctgctg ctggctgggg ccggaggggc cgctggcgat     1200

gaggctcggg aggctgcagc tgtgcgcgca ctggtcgcac gactgctggg acctgggcca     1260

gcagccgact tctctgtgag tgtcgagaga gccctggctg caaagcccgg actggatacc     1320

tacagtctgg gaggaggagg agcagctcga gtgagggtca gagggtcaac aggagtggca     1380

gcagctgcag gactgcaccg atatctgcga gacttttgcg gctgtcatgt ggcctggtca     1440

ggaagccagc tgaggctgcc cagacctctg ccagcagtgc caggcgagct gacagaagcc     1500

actcccaacc ggtaccgcta ctatcagaac gtgtgcaccc agtcctattc tttcgtctgg     1560

tgggactggg ctcgatggga gcgcgaaatc gattggatgg cactgaacgg aattaatctg     1620

gcactggcat ggtccggaca ggaggcaatc tggcagagag tgtacctggc actgggactg     1680

actcaggccg agattaacga gttcttcacc gggccagctt ttctggcatg gggacggatg     1740

gggaatctgc acacatggga cggaccactg ccaccttctt ggcacatcaa acagctgtat     1800

ctgcagcata gggtgctgga tcagatgaga agttttggca tgactccagt gctgcccgct     1860

ttcgcaggac acgtccctga ggccgtgaca cgcgtcttcc cacaggtgaa cgtcactaag     1920

atgggcagct ggggacactt caactgcagt tactcatgta gcttcctgct ggcccctgaa     1980

gatccaattt ttcccatcat tggaagcctg ttcctgcggg agctgatcaa agaatttgga     2040

accgaccaca tctacggggc cgatacattc aacgagatgc agccacccag ctccgaacct     2100

agctacctgg ccgctgcaac cacagccgtg tacgaggcca tgaccgctgt ggacacagaa     2160

gccgtctggc tgctgcaggg gtggctgttt cagcatcagc cacagttctg gggacctgca     2220

cagatccgag ctgtgctggg agcagtccca cgaggaaggc tgctggtgct ggatctgttc     2280

gctgagtccc agcccgtcta cactaggacc gcctctttcc agggccagcc ttttatttgg     2340

tgtatgctgc acaactttgg agggaatcat gggctgttcg gcgcactgga ggcagtgaac     2400

ggaggaccag aagcagctag actgtttcct aatagcacta tggtgggcac cggaatggct     2460

cccgagggca tctcacagaa tgaagtggtc tacagcctga tggcagagct gggatggcga     2520

aaggaccccg tgcctgatct ggcagcctgg gtcactagtt tcgctgcaag gagatacggg     2580

gtgtcacacc ctgacgctgg agcagcttgg cgactgctgc tgaggagcgt gtacaactgc     2640

agtggggagg cctgtagagg ccataatcgg tccccactgg tgcggcgccc ctcactgcag     2700

atgaacacca gcatctggta caatcgatcc gacgtgttcg aagcttggcg gctgctgctg     2760

acaagtgccc cttcactggc tacttctcca gcattccgct atgacctgct ggatctgaca     2820

aggcaggccg tgcaggagct ggtcagcctg tactatgagg aagctcgcag cgcatacctg     2880

tccaaggaac tggcatccct gctgagggca ggaggcgtgc tggcttatga gctgctgcca     2940

gctctggacg aagtcctggc atccgattct agatttctgc tgggcagctg gctggagcag     3000

gcacgagcag cagccgtgag cgaggccgaa gctgacttct acgagcagaa ctctaggtat     3060

cagctgactc tgtggggacc cgaagggaac atcctggatt acgcaaacaa gcagctggca     3120

ggactggtgg ctaattacta tacccctaga tggcggctgt ttctggaggc cctggtggac     3180

tctgtcgctc agggcattcc attccagcag caccagtttg ataagaacgt gttccagctg     3240

gaacaggcct tcgtcctgtc taaacagcgg tatcctagtc agccacgcgg cgacacagtg     3300

gacctggcaa agaagatttt cctgaaatac tatccccgct gggtggctgg ctcatggacc     3360

ggtggcgcgc cttcgaactg cagctcgagg taggatccag acatgataag atacattgat     3420

gagtttggac aaaccacaac tagaatgcag tgaaaaaaat gctttatttg tgaaatttgt     3480

gatgctattg ctttatttgt aaccattata agctgcaata aacaagttaa caacaacaat     3540

tgcattcatt ttatgtttca ggttcagggg gaggtgtggg aggtttttta gtcgactaga     3600

gctcgctgat cagcctcgac tgtgccttct agttgccagc catctgttgt ttgcccctcc     3660

cccgtgcctt ccttgaccct ggaaggtgcc actcccactg tcctttccta ataaaatgag     3720

gaaattgcat cgcattgtct gagtaggtgt cattctattc tggggggtgg ggtggggcag     3780

gacagcaagg gggaggattg ggaagacaat agcaggcatg ctggggagag atctaggaac     3840

ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact gaggccgccc     3900

gggcaaagcc cgggcgtcgg gcgacctttg gtcgcccggc ctcagtgagc gagcgagcgc     3960

gcagagaggg agtggccaac cccccccccc ccccccctgc agccagctgg cgtaatagcg     4020

aagaggcccg caccgatcgc ccttcccaac agttgcgtag cctgaatggc gaatggcgcg     4080

acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc agcgtgaccg     4140

ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc tttctcgcca     4200

cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg ttccgattta     4260

gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca cgtagtgggc     4320

catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc tttaatagtg     4380

gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct tttgatttat     4440

aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa caaaaattta     4500

acgcgaattt taacaaaata ttaacgttta caatttcctg atgcggtatt ttctccttac     4560

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     4620

cgcatagtta agccagcccc gacacccgcc aacacccgct gacgcgccct gacgggcttg     4680

tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct gcatgtgtca     4740

gaggttttca ccgtcatcac cgaaacgcgc gagacgaaag ggcctcgtga tacgcctatt     4800

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg     4860

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     4920

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     4980

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     5040

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     5100

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     5160

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     5220

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     5280

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     5340

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     5400

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     5460

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     5520

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     5580

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     5640

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     5700

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     5760

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     5820

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     5880

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     5940

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     6000

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     6060

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     6120

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     6180

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     6240

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     6300

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     6360

gacctacacc gaactgagat acctacagcg tgagcattga gaaagcgcca cgcttcccga     6420

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     6480

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     6540

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     6600

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     6660

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     6720

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgccc     6780

aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct gggctgca       6838


<210>  6
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Phe Phe Leu Tyr Tyr 
        435                 440                 445             


Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu 
    450                 455                 460                 


Gly Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn 
465                 470                 475                 480 


Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Val Thr 
                485                 490                 495     


Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr 
            500                 505                 510         


His Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala 
        515                 520                 525             


Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu 
    530                 535                 540                 


Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp 
545                 550                 555                 560 


Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala 
                565                 570                 575     


Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr 
            580                 585                 590         


Ala Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met 
        595                 600                 605             


Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys 
    610                 615                 620                 


Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly 
625                 630                 635                 640 


Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro 
                645                 650                 655     


Val Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser 
            660                 665                 670         


Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp 
        675                 680                 685             


Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr 
    690                 695                 700                 


Thr Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr 
705                 710                 715                 720 


Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Phe Leu Thr 
                725                 730                 735     


Arg Asn Leu 
            


<210>  7
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
atggaggctg tggctgtggc tgccgctgtg ggagtgctgc tgctggctgg ggccggaggg       60

gccgctggcg atgaggctcg ggaggctgca gctgtgcgcg cactggtcgc acgactgctg      120

ggacctgggc cagcagccga cttctctgtg agtgtcgaga gagccctggc tgcaaagccc      180

ggactggata cctacagtct gggaggagga ggagcagctc gagtgagggt cagagggtca      240

acaggagtgg cagcagctgc aggactgcac cgatatctgc gagacttttg cggctgtcat      300

gtggcctggt caggaagcca gctgaggctg cccagacctc tgccagcagt gccaggcgag      360

ctgacagaag ccactcccaa ccggtaccgc tactatcaga acgtgtgcac ccagtcctat      420

tctttcgtct ggtgggactg ggctcgatgg gagcgcgaaa tcgattggat ggcactgaac      480

ggaattaatc tggcactggc atggtccgga caggaggcaa tctggcagag agtgtacctg      540

gcactgggac tgactcaggc cgagattaac gagttcttca ccgggccagc ttttctggca      600

tggggacgga tggggaatct gcacacatgg gacggaccac tgccaccttc ttggcacatc      660

aaacagctgt atctgcagca tagggtgctg gatcagatga gaagttttgg catgactcca      720

gtgctgcccg ctttcgcagg acacgtccct gaggccgtga cacgcgtctt cccacaggtg      780

aacgtcacta agatgggcag ctggggacac ttcaactgca gttactcatg tagcttcctg      840

ctggcccctg aagatccaat ttttcccatc attggaagcc tgttcctgcg ggagctgatc      900

aaagaatttg gaaccgacca catctacggg gccgatacat tcaacgagat gcagccaccc      960

agctccgaac ctagctacct ggccgctgca accacagccg tgtacgaggc catgaccgct     1020

gtggacacag aagccgtctg gctgctgcag gggtggctgt ttcagcatca gccacagttc     1080

tggggacctg cacagatccg agctgtgctg ggagcagtcc cacgaggaag gctgctggtg     1140

ctggatctgt tcgctgagtc ccagcccgtc tacactagga ccgcctcttt ccagggccag     1200

ccttttattt ggtgtatgct gcacaacttt ggagggaatc atgggctgtt cggcgcactg     1260

gaggcagtga acggaggacc agaagcagct agactgtttc ctaatagcac tatggtgggc     1320

accggaatgg ctcccgaggg catctcacag aatgaagtgg tctacagcct gatggcagag     1380

ctgggatggc gaaaggaccc cgtgcctgat ctggcagcct gggtcactag tttcgctgca     1440

aggagatacg gggtgtcaca ccctgacgct ggagcagctt ggcgactgct gctgaggagc     1500

gtgtacaact gcagtgggga ggcctgtaga ggccataatc ggtccccact ggtgcggcgc     1560

ccctcactgc agatgaacac cagcatctgg tacaatcgat ccgacgtgtt cgaagcttgg     1620

cggctgctgc tgacaagtgc cccttcactg gctacttctc cagcattccg ctatgacctg     1680

ctggatctga caaggcaggc cgtgcaggag ctggtcagcc tgtactatga ggaagctcgc     1740

agcgcatacc tgtccaagga actggcatcc ctgctgaggg caggaggcgt gctggcttat     1800

gagctgctgc cagctctgga cgaagtcctg gcatccgatt ctagatttct gctgggcagc     1860

tggctggagc aggcacgagc agcagccgtg agcgaggccg aagctgactt ctacgagcag     1920

aactctaggt atcagctgac tctgtgggga cccgaaggga acatcctgga ttacgcaaac     1980

aagcagctgg caggactggt ggctaattac tataccccta gatggcggct gtttctggag     2040

gccctggtgg actctgtcgc tcagggcatt ccattccagc agcaccagtt tgataagaac     2100

gtgttccagc tggaacaggc cttcgtcctg tctaaacagc ggtatcctag tcagccacgc     2160

ggcgacacag tggacctggc aaagaagatt ttcctgaaat actatccccg ctgggtggct     2220

ggctcatggt aa                                                         2232


