                         SEQUENCE LISTING

<110>  Invetx Inc.
 
<120>  COMPOSITIONS FOR INCREASING HALF-LIFE OF A THERAPEUTIC AGENT IN 
       CANINES AND METHODS OF USE

<130>  47406-0015WO1

<150>  63/122,417
<151>  2020-12-07

<150>  63/023,083
<151>  2020-05-11

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  104
<212>  PRT
<213>  Canine

<400>  1

Gly Pro Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
1               5                   10                  15      


Ile Thr Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg 
            20                  25                  30          


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
        35                  40                  45              


His Thr Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Arg 
            100                 


<210>  2
<211>  104
<212>  PRT
<213>  Canine

<400>  2

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu 
1               5                   10                  15      


Ile Ala Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro 
            20                  25                  30          


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met 
        35                  40                  45              


Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly 
65                  70                  75                  80  


Lys Gln Phe Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Arg 
            100                 


<210>  3
<211>  104
<212>  PRT
<213>  Canine

<400>  3

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Val 
1               5                   10                  15      


Thr Ala Arg Thr Pro Thr Val Thr Cys Val Val Val Asp Leu Asp Pro 
            20                  25                  30          


Glu Asn Pro Glu Val Gln Ile Ser Trp Phe Val Asp Ser Lys Gln Val 
        35                  40                  45              


Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu Gln Ser Asn Gly Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Ser Gly 
65                  70                  75                  80  


Lys Gln Phe Lys Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile 
                85                  90                  95      


Glu Glu Ile Ile Ser Lys Thr Pro 
            100                 


<210>  4
<211>  104
<212>  PRT
<213>  Canine

<400>  4

Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg 
1               5                   10                  15      


Ile Thr Arg Thr Pro Glu Ile Thr Cys Val Val Leu Asp Leu Gly Arg 
            20                  25                  30          


Glu Asp Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val 
        35                  40                  45              


His Thr Ala Lys Thr Gln Pro Arg Glu Gln Gln Phe Asn Ser Thr Tyr 
    50                  55                  60                  


Arg Val Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly 
65                  70                  75                  80  


Lys Glu Phe Lys Cys Arg Val Asn His Ile Gly Leu Pro Ser Pro Ile 
                85                  90                  95      


Glu Arg Thr Ile Ser Lys Ala Arg 
            100                 


<210>  5
<211>  106
<212>  PRT
<213>  Canine

<400>  5

Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser 
1               5                   10                  15      


Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro 
            20                  25                  30          


Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg 
        35                  40                  45              


Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
    50                  55                  60                  


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp 
65                  70                  75                  80  


Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn His Tyr Thr 
                85                  90                  95      


Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
            100                 105     


<210>  6
<211>  105
<212>  PRT
<213>  Canine

<400>  6

Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu Ser Lys 
1               5                   10                  15      


Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro Asp 
            20                  25                  30          


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys 
        35                  40                  45              


Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr 
65                  70                  75                  80  


Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Glu Ser Leu Ser His Ser Pro Gly Lys 
            100                 105 


<210>  7
<211>  105
<212>  PRT
<213>  Canine

<400>  7

Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met Ser Lys 
1               5                   10                  15      


Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro Pro Glu 
            20                  25                  30          


Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu Ser Lys 
        35                  40                  45              


Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu 
    50                  55                  60                  


Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly Asp Thr 
65                  70                  75                  80  


Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                85                  90                  95      


Ile Ser Leu Ser His Ser Pro Gly Lys 
            100                 105 


<210>  8
<211>  106
<212>  PRT
<213>  Canine

<400>  8

Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser 
1               5                   10                  15      


Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro Pro 
            20                  25                  30          


Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro Glu Ser 
        35                  40                  45              


Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe 
    50                  55                  60                  


Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln Gly Asp 
65                  70                  75                  80  


Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn His Tyr Thr 
                85                  90                  95      


Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
            100                 105     


<210>  9
<211>  220
<212>  PRT
<213>  Canine

<400>  9

Val Pro Glu Pro Leu Gly Gly Pro Ser Val Leu Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Ser Arg Glu Gln 
    50                  55                  60                  


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His 
65                  70                  75                  80  


Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile 
                85                  90                  95      


Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Arg 
            100                 105                 110         


Ala His Lys Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu 
        115                 120                 125             


Ser Ser Ser Asp Thr Val Ser Ile Thr Cys Leu Ile Lys Asp Phe Tyr 
    130                 135                 140                 


Pro Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro 
145                 150                 155                 160 


Glu Arg Lys His Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asp Pro Phe Thr Cys Ala Val Met His Glu Thr Leu Gln Asn His 
        195                 200                 205             


Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  10
<211>  219
<212>  PRT
<213>  Canine

<400>  10

Ala Pro Glu Met Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Leu Ile Ala Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Leu Asp Pro Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asp Gly Lys Gln Met Gln Thr Ala Lys Thr Gln Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
65                  70                  75                  80  


Gln Asp Trp Leu Lys Gly Lys Gln Phe Thr Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Ala Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
            100                 105                 110         


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Arg Glu Glu Leu 
        115                 120                 125             


Ser Lys Asn Thr Val Ser Leu Thr Cys Leu Ile Lys Asp Phe Phe Pro 
    130                 135                 140                 


Pro Asp Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
145                 150                 155                 160 


Ser Lys Tyr Arg Thr Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
                165                 170                 175     


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
            180                 185                 190         


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
        195                 200                 205             


Thr Gln Glu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 


<210>  11
<211>  219
<212>  PRT
<213>  Canine

<400>  11

Gly Cys Gly Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Ile Leu Val Thr Ala Arg Thr Pro Thr Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Leu Asp Pro Glu Asn Pro Glu Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asp Ser Lys Gln Val Gln Thr Ala Asn Thr Gln Pro Arg Glu Glu 
    50                  55                  60                  


Gln Ser Asn Gly Thr Tyr Arg Val Val Ser Val Leu Pro Ile Gly His 
65                  70                  75                  80  


Gln Asp Trp Leu Ser Gly Lys Gln Phe Lys Cys Lys Val Asn Asn Lys 
                85                  90                  95      


Ala Leu Pro Ser Pro Ile Glu Glu Ile Ile Ser Lys Thr Pro Gly Gln 
            100                 105                 110         


Ala His Gln Pro Asn Val Tyr Val Leu Pro Pro Ser Arg Asp Glu Met 
        115                 120                 125             


Ser Lys Asn Thr Val Thr Leu Thr Cys Leu Val Lys Asp Phe Phe Pro 
    130                 135                 140                 


Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Gln Glu Pro Glu 
145                 150                 155                 160 


Ser Lys Tyr Arg Met Thr Pro Pro Gln Leu Asp Glu Asp Gly Ser Tyr 
                165                 170                 175     


Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Arg Gly 
            180                 185                 190         


Asp Thr Phe Ile Cys Ala Val Met His Glu Ala Leu His Asn His Tyr 
        195                 200                 205             


Thr Gln Ile Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 


<210>  12
<211>  220
<212>  PRT
<213>  Canine

<400>  12

Val Pro Glu Ser Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Ile Leu Arg Ile Thr Arg Thr Pro Glu Ile Thr Cys Val 
            20                  25                  30          


Val Leu Asp Leu Gly Arg Glu Asp Pro Glu Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asp Gly Lys Glu Val His Thr Ala Lys Thr Gln Pro Arg Glu Gln 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Pro Ile Glu His 
65                  70                  75                  80  


Gln Asp Trp Leu Thr Gly Lys Glu Phe Lys Cys Arg Val Asn His Ile 
                85                  90                  95      


Gly Leu Pro Ser Pro Ile Glu Arg Thr Ile Ser Lys Ala Arg Gly Gln 
            100                 105                 110         


Ala His Gln Pro Ser Val Tyr Val Leu Pro Pro Ser Pro Lys Glu Leu 
        115                 120                 125             


Ser Ser Ser Asp Thr Val Thr Leu Thr Cys Leu Ile Lys Asp Phe Phe 
    130                 135                 140                 


Pro Pro Glu Ile Asp Val Glu Trp Gln Ser Asn Gly Gln Pro Glu Pro 
145                 150                 155                 160 


Glu Ser Lys Tyr His Thr Thr Ala Pro Gln Leu Asp Glu Asp Gly Ser 
                165                 170                 175     


Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asp Thr Phe Thr Cys Ala Val Met His Glu Ala Leu Gln Asn His 
        195                 200                 205             


Tyr Thr Asp Leu Ser Leu Ser His Ser Pro Gly Lys 
    210                 215                 220 


<210>  13
<211>  468
<212>  PRT
<213>  Canine

<400>  13

Met Glu Ser Val Phe Cys Trp Val Phe Leu Val Val Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Gly Glu Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Tyr Tyr Met His Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Gln Arg Val Ala His Ile Arg Gly Asp Gly Arg Thr Thr His Tyr Ala 
65                  70                  75                  80  


Asp Ala Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Asn Ser Leu Thr Val Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Val Lys Asp Ile Tyr Tyr Gly Val Gly Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Thr Ala Pro Ser 
    130                 135                 140                 


Val Phe Pro Leu Ala Pro Ser Cys Gly Ser Thr Ser Gly Ser Thr Val 
145                 150                 155                 160 


Ala Leu Ala Cys Leu Val Ser Gly Tyr Phe Pro Glu Pro Val Thr Val 
                165                 170                 175     


Ser Trp Asn Ser Gly Ser Leu Thr Ser Gly Val His Thr Phe Pro Ser 
            180                 185                 190         


Val Leu Gln Ser Ser Gly Leu His Ser Leu Ser Ser Met Val Thr Val 
        195                 200                 205             


Pro Ser Ser Arg Trp Pro Ser Glu Thr Phe Thr Cys Asn Val Val His 
    210                 215                 220                 


Pro Ala Ser Asn Thr Lys Val Asp Lys Pro Val Phe Asn Glu Cys Arg 
225                 230                 235                 240 


Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu Pro Leu Gly Gly Pro 
                245                 250                 255     


Ser Val Leu Ile Phe Pro Pro Lys Pro Lys Asp Ile Leu Arg Ile Thr 
            260                 265                 270         


Arg Thr Pro Glu Val Thr Cys Val Val Leu Asp Leu Gly Arg Glu Asp 
        275                 280                 285             


Pro Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Glu Val His Thr 
    290                 295                 300                 


Ala Lys Thr Gln Ser Arg Glu Gln Gln Phe Asn Gly Thr Tyr Arg Val 
305                 310                 315                 320 


Val Ser Val Leu Pro Ile Glu His Gln Asp Trp Leu Thr Gly Lys Glu 
                325                 330                 335     


Phe Lys Cys Arg Val Asn His Ile Asp Leu Pro Ser Pro Ile Glu Arg 
            340                 345                 350         


Thr Ile Ser Lys Ala Arg Gly Arg Ala His Lys Pro Ser Val Tyr Val 
        355                 360                 365             


Leu Pro Pro Ser Pro Lys Glu Leu Ser Ser Ser Asp Thr Val Ser Ile 
    370                 375                 380                 


Thr Cys Leu Ile Lys Asp Phe Tyr Pro Pro Asp Ile Asp Val Glu Trp 
385                 390                 395                 400 


Gln Ser Asn Gly Gln Gln Glu Pro Glu Arg Lys His Arg Met Thr Pro 
                405                 410                 415     


Pro Gln Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asp Pro Phe Thr Cys Ala Val 
        435                 440                 445             


Met His Glu Thr Leu Gln Asn His Tyr Thr Asp Leu Ser Leu Ser His 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  14
<211>  96
<212>  PRT
<213>  Canine

<400>  14

Leu Phe Thr Arg Thr Lys Arg Arg Ser Asp Val Ser Trp Gly Asn Thr 
1               5                   10                  15      


Gly Ser Ser Gln Thr Val Ile Arg Ala Ser Val Ala Ser Trp Ser Arg 
            20                  25                  30          


Asn Gly Asp Leu Tyr Ala Pro Lys Pro Lys Arg Glu Asn Gly Arg Val 
        35                  40                  45              


Pro Arg Pro Pro Asp Cys Lys Ala Met Phe Thr Leu Leu Ala Val Asp 
    50                  55                  60                  


Pro Gln Met Gln Pro Glu Gly Lys Gln Thr Lys Asn Lys Ala Gln Gln 
65                  70                  75                  80  


Arg Glu Lys Asn Leu Phe Ser Tyr Thr Arg Thr Ile Ala His Gln Glu 
                85                  90                  95      


<210>  15
<211>  105
<212>  PRT
<213>  Canine

<400>  15

Leu Tyr Ala Asp Cys Ala Ser Val Ser Pro Trp Thr Tyr Ser Asp Ile 
1               5                   10                  15      


Tyr Ser Val Arg Ala Val Ala Ala Pro Tyr Asp Ser His Tyr Met Pro 
            20                  25                  30          


Ser Leu Phe Gln Ile Val Tyr Ala Thr Ala Lys Glu Lys Cys Asn Cys 
        35                  40                  45              


Asn Asn Cys Gly Cys Gly Leu Phe Val Thr Ala Thr Val Asp Pro Asn 
    50                  55                  60                  


Ser Gln Gln Asn Pro Glu Ser Gly Ser Gln Lys Asn Lys Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Gln Gln Asn Arg Asp Met Lys Asn Thr Leu Val Phe Glu Ser 
                85                  90                  95      


Tyr Met Arg Thr Ile Ala His Gln Ile 
            100                 105 


<210>  16
<211>  66
<212>  PRT
<213>  Canine

<400>  16

Leu Ser Asp Gly Ser Val Ser Trp Ala Val Ser Asn Arg Asp Tyr Ser 
1               5                   10                  15      


Lys Ala Ile His Val Thr Gly Val Trp Pro Arg His Met His Asn Ser 
            20                  25                  30          


Leu Phe Tyr Thr Pro Lys Ser Thr Lys Cys Ile Ser Pro Glu Ser Phe 
        35                  40                  45              


Ile Pro Ser Gly Gln Gln Thr Leu Phe Glu Pro Ser Tyr His Thr Ala 
    50                  55                  60                  


Thr Ala 
65      


<210>  17
<211>  17
<212>  PRT
<213>  Canine

<400>  17

Phe Asn Glu Cys Arg Cys Thr Asp Thr Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Pro 
    


<210>  18
<211>  22
<212>  PRT
<213>  Canine

<400>  18

Pro Lys Arg Glu Asn Gly Arg Val Pro Arg Pro Pro Asp Cys Pro Lys 
1               5                   10                  15      


Cys Pro Ala Pro Glu Met 
            20          


<210>  19
<211>  20
<212>  PRT
<213>  Canine

<400>  19

Ala Lys Glu Cys Glu Cys Lys Cys Asn Cys Asn Asn Cys Pro Cys Pro 
1               5                   10                  15      


Gly Cys Gly Leu 
            20  


<210>  20
<211>  17
<212>  PRT
<213>  Canine

<400>  20

Pro Lys Glu Ser Thr Cys Lys Cys Ile Ser Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Ser 
    


<210>  21
<211>  17
<212>  PRT
<213>  Canine

<400>  21

Pro Lys Glu Ser Thr Cys Lys Cys Ile Pro Pro Cys Pro Val Pro Glu 
1               5                   10                  15      


Ser 
    


<210>  22
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  22

Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Ser Glu Arg 
1               5                   10          


<210>  23
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  23

Ser Glu Arg Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr 
1               5                   10          


<210>  24
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  24

Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Ser Glu Arg 
1               5                   10                  15  


<210>  25
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  25

Ser Glu Arg Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr 
1               5                   10                  15  


<210>  26
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  26

Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Ser 
1               5                   10                  15      


Glu Arg 
        


<210>  27
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  27

Ser Glu Arg Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly 
1               5                   10                  15      


Leu Tyr 
        


<210>  28
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  28

Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly 
1               5                   10                  15      


Leu Tyr Ser Glu Arg 
            20      


<210>  29
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic polypeptide

<400>  29

Ser Glu Arg Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly Leu Tyr Gly 
1               5                   10                  15      


Leu Tyr Gly Leu Tyr 
            20      


<210>  30
<211>  202
<212>  PRT
<213>  Canine

<400>  30

Val Phe Ile Phe Pro Pro Lys Pro Lys Asp Thr Leu Leu Ile Ala Arg 
1               5                   10                  15      


Thr Pro Glu Val Thr Cys Val Val Val Asp Leu Asp Pro Glu Asp Pro 
            20                  25                  30          


Glu Val Gln Ile Ser Trp Phe Val Asp Gly Lys Gln Met Gln Thr Ala 
        35                  40                  45              


Lys Thr Gln Pro Arg Glu Glu Gln Phe Asn Gly Thr Tyr Arg Val Val 
    50                  55                  60                  


Ser Val Leu Pro Ile Gly His Gln Asp Trp Leu Lys Gly Lys Gln Phe 
65                  70                  75                  80  


Thr Cys Lys Val Asn Asn Lys Ala Leu Pro Ser Pro Ile Glu Arg Thr 
                85                  90                  95      


Ile Ser Lys Ala Arg Gly Gln Ala His Gln Pro Ser Val Tyr Val Leu 
            100                 105                 110         


Pro Pro Ser Arg Glu Glu Leu Ser Lys Asn Thr Val Ser Leu Thr Cys 
        115                 120                 125             


Leu Ile Lys Asp Phe Phe Pro Pro Asp Ile Asp Val Glu Trp Gln Ser 
    130                 135                 140                 


Asn Gly Gln Gln Glu Pro Glu Ser Lys Tyr Arg Thr Thr Pro Pro Gln 
145                 150                 155                 160 


Leu Asp Glu Asp Gly Ser Tyr Phe Leu Tyr Ser Lys Leu Ser Val Asp 
                165                 170                 175     


Lys Ser Arg Trp Gln Arg Gly Asp Thr Phe Ile Cys Ala Val Met His 
            180                 185                 190         


Glu Ala Leu His Asn His Tyr Thr Gln Glu 
        195                 200         


<210>  31
<211>  200
<212>  PRT
<213>  human

<400>  31

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
1               5                   10                  15      


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            20                  25                  30          


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        35                  40                  45              


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    50                  55                  60                  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
65                  70                  75                  80  


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                85                  90                  95      


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            100                 105                 110         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        115                 120                 125             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    130                 135                 140                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
145                 150                 155                 160 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                165                 170                 175     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            180                 185                 190         


Leu His Asn His Tyr Thr Gln Lys 
        195                 200 


