                               SEQUENCE LISTING

<110> LIFEEDIT THERAPEUTICS, INC.
 
<120> RNA-GUIDED NUCLEIC ACID BINDING PROTEINS AND ACTIVE FRAGMENTS AND
      VARIANTS THEREOF AND METHODS OF USE

<130> L103438 1210WO (0086.7)

<140>
<141>

<150> 63/023,009
<151> 2020-05-11

<160> 90    

<170> PatentIn version 3.5

<210> 1
<211> 782
<212> PRT
<213> Bacillus sp.

<400> 1
Met Lys Leu Lys Arg Gly Leu Leu Val Leu Cys Thr Ser Thr Ala Leu 
1               5                   10                  15      


Ile Tyr Pro Ser Ile Val Asn Ala Lys Asn Asn Asp Val Pro Phe Tyr 
            20                  25                  30          


Asp Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro 
        35                  40                  45              


Gly Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu 
    50                  55                  60                  


Tyr Arg Ala Asp Ile His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn 
65                  70                  75                  80  


Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu 
                85                  90                  95      


Pro Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro 
            100                 105                 110         


Ala Gly Asp Arg Met Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val 
        115                 120                 125             


Ile Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile 
    130                 135                 140                 


Asp Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln 
145                 150                 155                 160 


Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly 
                165                 170                 175     


Ala Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg 
            180                 185                 190         


Thr Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys 
        195                 200                 205             


Asp Val Pro Val Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys 
    210                 215                 220                 


Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro 
225                 230                 235                 240 


Tyr Gln Ala Ala Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp 
                245                 250                 255     


Ile Thr Lys Asp Gly Glu Thr Val His His Gln Glu Asn Tyr Leu Arg 
            260                 265                 270         


Ser Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly 
        275                 280                 285             


Lys Phe Val Lys Asp Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln 
    290                 295                 300                 


Tyr Thr Ala Lys Ile Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn 
305                 310                 315                 320 


Glu Lys Asn Val Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val 
                325                 330                 335     


Thr Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile 
            340                 345                 350         


Asp Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys 
        355                 360                 365             


Asn Ile Lys Thr Arg Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu 
    370                 375                 380                 


Arg Asp Gln Tyr Arg Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln 
385                 390                 395                 400 


Gln Glu Val Asn Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser 
                405                 410                 415     


Leu Ser Tyr Cys Arg Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly 
            420                 425                 430         


Lys Asp His Tyr Tyr Asp Arg Asp Cys Ser Trp Glu Glu Asn Lys Leu 
        435                 440                 445             


Asp Ser Ala Ala Ser Lys Leu Asp Asn Ala Arg Gln Lys Phe Glu Lys 
    450                 455                 460                 


Glu Lys Asn Lys Leu Lys Lys Leu Asp Val Leu Glu Glu Lys Tyr Thr 
465                 470                 475                 480 


Asn Pro Glu Thr Val Val Val Leu Lys His Asn Gly Gln Gln Val Ala 
                485                 490                 495     


Leu Gln Lys Val Arg Leu Thr Glu Gly Glu Lys Lys Thr Leu Asn Leu 
            500                 505                 510         


Asp Trp Gln His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro 
        515                 520                 525             


Ala Gly Asn Arg Ile Asp Ile Glu Glu Thr Thr Tyr Lys Asn Asn Pro 
    530                 535                 540                 


Ile Lys Thr Ala Ile Tyr Glu Pro Ser Lys Glu Lys Ala Met Cys Gly 
545                 550                 555                 560 


Val Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Glu Arg Val Ser 
                565                 570                 575     


Lys Glu Asp Ile Thr Gly Glu Met Tyr Tyr Glu Thr Leu Thr Gly Ser 
            580                 585                 590         


Ile Asp Asn Leu Ala Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Ser 
        595                 600                 605             


Tyr Glu Val Asn Gly Lys Tyr Lys Asn Asp Trp Asn Ala Asn Tyr Pro 
    610                 615                 620                 


Gly Val Phe Thr Ala Ala Lys Ala Gln Tyr Pro Phe Ala Asp Glu Gly 
625                 630                 635                 640 


Leu Lys Ser Thr Gln Asp Leu Glu Lys Lys Glu Leu Lys Asp Asn Thr 
                645                 650                 655     


Ala Lys Phe Leu Pro Lys Asn Met Tyr Leu Ser Glu Ala Thr Gly His 
            660                 665                 670         


Val Phe Asp Ser Lys Arg Pro Thr Lys Ser Leu Tyr Trp Asp Gly Gln 
        675                 680                 685             


Glu Lys Ile Ile Asp Gly Gly Gln Lys Trp Tyr Ser Pro Leu Lys Thr 
    690                 695                 700                 


Lys Asp Gly Val Tyr Thr Phe Asn Val Glu Thr Ala Pro Ala Gly Ile 
705                 710                 715                 720 


Asn Glu Met Ser Leu Cys Leu Thr Glu Gln Val Glu Ile Lys Gly Val 
                725                 730                 735     


Ala Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe 
            740                 745                 750         


Pro Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu 
        755                 760                 765             


Leu His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Thr Gly Lys 
    770                 775                 780         


<210> 2
<211> 759
<212> PRT
<213> Bacillus sp.

<400> 2
Met Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn Asp Thr Phe 
1               5                   10                  15      


Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe Arg Pro Gly 
            20                  25                  30          


Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp Ile His Phe 
        35                  40                  45              


Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn 
    50                  55                  60                  


Leu Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ala Asn 
65                  70                  75                  80  


Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg Met Val Thr 
                85                  90                  95      


Glu Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys Tyr Trp Gly 
            100                 105                 110         


Asn Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser Ile Asn Thr 
        115                 120                 125             


Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile Arg Asp Ile 
    130                 135                 140                 


Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Glu Gly Ile 
145                 150                 155                 160 


Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro Glu Leu Lys 
                165                 170                 175     


Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val Lys Phe Thr 
            180                 185                 190         


Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg 
        195                 200                 205             


Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala Ala Gly Glu 
    210                 215                 220                 


Arg Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp Gly Glu Thr 
225                 230                 235                 240 


Val His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln Lys Asp Asn 
                245                 250                 255     


Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys Asp Asp Val 
            260                 265                 270         


Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys Ile Lys Val 
        275                 280                 285             


Leu Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val Asp Phe Thr 
    290                 295                 300                 


Ile Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro Asp Pro Gly 
305                 310                 315                 320 


Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala Asp Arg Ile 
                325                 330                 335     


Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr Arg Val Asp 
            340                 345                 350         


Val Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr Arg Val Lys 
        355                 360                 365             


Val Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn Ser Ser Glu 
    370                 375                 380                 


Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys Arg Arg Asn 
385                 390                 395                 400 


Pro Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr Tyr Asp Arg 
                405                 410                 415     


Asp Cys Ser Trp Glu Glu Asn Lys Leu Asp Ser Ala Ala Ser Lys Leu 
            420                 425                 430         


Asp Asn Ala Arg Gln Lys Phe Glu Lys Glu Lys Asn Lys Leu Lys Lys 
        435                 440                 445             


Leu Asp Val Leu Glu Glu Lys Tyr Thr Asn Pro Glu Thr Val Val Val 
    450                 455                 460                 


Leu Lys His Asn Gly Gln Gln Val Ala Leu Gln Lys Val Arg Leu Thr 
465                 470                 475                 480 


Glu Gly Glu Lys Lys Thr Leu Asn Leu Asp Trp Gln His Lys Gly Lys 
                485                 490                 495     


Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala Gly Asn Arg Ile Asp Ile 
            500                 505                 510         


Glu Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile Tyr Glu 
        515                 520                 525             


Pro Ser Lys Glu Lys Ala Met Cys Gly Val Thr Ser Val Lys Gly Val 
    530                 535                 540                 


Val Glu Thr Val Ser Glu Arg Val Ser Lys Glu Asp Ile Thr Gly Glu 
545                 550                 555                 560 


Met Tyr Tyr Glu Thr Leu Thr Gly Ser Ile Asp Asn Leu Ala Pro Ser 
                565                 570                 575     


Lys Leu His Ser Gly Tyr Gly Phe Ser Tyr Glu Val Asn Gly Lys Tyr 
            580                 585                 590         


Lys Asn Asp Trp Asn Ala Asn Tyr Pro Gly Val Phe Thr Ala Ala Lys 
        595                 600                 605             


Ala Gln Tyr Pro Phe Ala Asp Glu Gly Leu Lys Ser Thr Gln Asp Leu 
    610                 615                 620                 


Glu Lys Lys Glu Leu Lys Asp Asn Thr Ala Lys Phe Leu Pro Lys Asn 
625                 630                 635                 640 


Met Tyr Leu Ser Glu Ala Thr Gly His Val Phe Asp Ser Lys Arg Pro 
                645                 650                 655     


Thr Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp Gly Gly 
            660                 665                 670         


Gln Lys Trp Tyr Ser Pro Leu Lys Thr Lys Asp Gly Val Tyr Thr Phe 
        675                 680                 685             


Asn Val Glu Thr Ala Pro Ala Gly Ile Asn Glu Met Ser Leu Cys Leu 
    690                 695                 700                 


Thr Glu Gln Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe Ile Lys 
705                 710                 715                 720 


Arg Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly Val Gly 
                725                 730                 735     


Trp Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr Asp Trp 
            740                 745                 750         


Tyr Tyr Met Lys Thr Gly Lys 
        755                 


<210> 3
<211> 789
<212> PRT
<213> Bacillus sp.

<400> 3
Met Lys Phe Lys Lys Gly Ile Phe Val Leu Phe Thr Ser Val Leu Leu 
1               5                   10                  15      


Ser Ala Pro Asn Ser Ala Asp Ala Lys Asn Asn Asp Val Pro Phe Tyr 
            20                  25                  30          


Asn Gly Asn Glu Asp Thr Phe Val Lys Ser Ala Gln Leu Gln Met Pro 
        35                  40                  45              


Gly Lys Tyr Phe Arg Pro Gly Ser Tyr Ser Pro Gln Gly Thr Asp Leu 
    50                  55                  60                  


Met Tyr Lys Gly Asp Ile His Tyr Pro Ala Val Tyr Asn Gly Ser Phe 
65                  70                  75                  80  


Asn Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Gly Asn Asp Ser Ser 
                85                  90                  95      


Glu Pro Tyr Ile Arg Ile Ser Asn Glu Gly Tyr Phe Asn Ser Ser Val 
            100                 105                 110         


Pro Val Gly Asp Arg Met Val Thr Glu Ile Glu Arg Val Thr Glu Pro 
        115                 120                 125             


Ile Ile Ser Asn Lys Tyr Trp Gly Asn Pro Glu Phe Val Leu Gly Asn 
    130                 135                 140                 


Ile Lys Glu His Ile Ile Arg Asn Asp Lys Thr Asn Glu Met Tyr Gly 
145                 150                 155                 160 


Gln Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala 
                165                 170                 175     


Gly Ala Gly Ala Val Asp Asn Val Asn Asn Tyr Asn Leu Trp Tyr Val 
            180                 185                 190         


Arg Thr Ser Lys Pro Glu Leu Lys Glu Phe Lys Ala Ser Ser Gly Lys 
        195                 200                 205             


Lys Asp Asp Pro Val Lys Phe Ile Phe Asn Gly Phe Glu Tyr Val Ser 
    210                 215                 220                 


Lys Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn 
225                 230                 235                 240 


Pro Tyr Gln Ser Glu Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu 
                245                 250                 255     


Asp Ile Ile Lys Asn Gly Glu Thr Val His His Gln Gly Asn Tyr Leu 
            260                 265                 270         


Arg Ser Asn Pro Gln Lys Asn Asn Asp Lys Pro Asn Glu Gly Asp Ala 
        275                 280                 285             


Gly Tyr Phe Ser Lys Glu Gly Ile Pro Phe Tyr Pro Gln Glu Cys Gly 
    290                 295                 300                 


Arg Tyr Thr Ala Lys Leu Lys Leu Ile Asp Ala Val Gln Arg Glu Ser 
305                 310                 315                 320 


Thr Glu Lys Val Val Asp Phe Val Val Asp Gly Ser Cys Gly Thr Gln 
                325                 330                 335     


Val Pro Pro Thr Thr Asp Pro Val Asp Gly Glu Phe Asn Tyr Lys Ile 
            340                 345                 350         


Asp Tyr Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Lys Asp Lys 
        355                 360                 365             


Glu Ile Lys Thr Arg Val Asp Val Ser Arg Ala Ser Phe Lys Glu Glu 
    370                 375                 380                 


His Asp Gln Tyr Arg Ala Lys Leu Asp Glu Glu Phe Lys Lys Tyr Gln 
385                 390                 395                 400 


Lys Glu Val Asp Ala Tyr Ile Ser Glu Arg Asp Ser Ala Gln Asp Ser 
                405                 410                 415     


Leu Asn Tyr Cys Arg Arg Asn Pro Ile Arg Glu Glu Asp Glu Lys Gly 
            420                 425                 430         


Gly Val His Tyr Arg Asp Arg Asp Cys Ser Trp Glu Glu Asn Asn Leu 
        435                 440                 445             


Asp Asn Val Val Ser Lys Leu Glu Lys Ala Lys Gln Asn Arg Glu Lys 
    450                 455                 460                 


Leu Ser Lys Lys Leu Gly Asp Phe Asp Lys Leu Asn Ala Gln Tyr His 
465                 470                 475                 480 


Asn Pro Glu Val Thr Val Ile Leu Lys His Asn Gly Lys Lys Val Glu 
                485                 490                 495     


Ser Lys Thr Val Arg Leu Lys Glu Gly Glu Lys Lys Thr Val Phe Phe 
            500                 505                 510         


Asn Trp Glu His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro 
        515                 520                 525             


Ala Asp Glu Asp Gly Ser Arg Leu Asp Ile Lys Glu Thr Thr Tyr Lys 
    530                 535                 540                 


Asn Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro Ser Gln Glu Lys Ala 
545                 550                 555                 560 


Met Cys Gly Ala Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Asn 
                565                 570                 575     


Arg Val Ser Val Glu Asp Thr Val Gly Glu Met Tyr His Glu Thr Leu 
            580                 585                 590         


Thr Gly Ser Ile Asp Lys Leu Val Pro Ser Lys Leu His Ser Gly Tyr 
        595                 600                 605             


Gly Phe Thr Tyr Glu Leu Asp Gly Lys Tyr Thr Asn Asn Trp Asp Gln 
    610                 615                 620                 


Asn Tyr Gln Gly Val Phe Thr Val Ala Thr Ala Lys Tyr Pro Phe Ala 
625                 630                 635                 640 


Asp Glu Gly Leu Lys Leu Asn Gln Asp Leu Glu Lys Lys Glu Ile Lys 
                645                 650                 655     


Asp Asn Thr Ser Lys Phe Ile Pro Lys Asn Met Tyr Leu Ser Glu Lys 
            660                 665                 670         


Thr Gly Tyr Val Phe Asp Ser Lys Arg Pro Ile Lys Ser Leu Tyr Trp 
        675                 680                 685             


Asp Gly Gln Glu Lys Ile Ile Asp Gly Gly His Lys Trp Tyr Ala Pro 
    690                 695                 700                 


Met Lys Thr Lys Asp Gly Lys Tyr Ser Phe Lys Val Glu Thr Lys Pro 
705                 710                 715                 720 


Thr Gly Ile Asn Glu Met Ser Leu Cys Met Thr Glu Glu Val Glu Ile 
                725                 730                 735     


Lys Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp 
            740                 745                 750         


Asp Pro Phe Pro Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys 
        755                 760                 765             


Glu Glu Leu Leu His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Asn Gly 
    770                 775                 780                 


Asn Lys Asn Lys Ile 
785                 


<210> 4
<211> 766
<212> PRT
<213> Bacillus sp.

<400> 4
Met Lys Asn Asn Asp Val Pro Phe Tyr Asn Gly Asn Glu Asp Thr Phe 
1               5                   10                  15      


Val Lys Ser Ala Gln Leu Gln Met Pro Gly Lys Tyr Phe Arg Pro Gly 
            20                  25                  30          


Ser Tyr Ser Pro Gln Gly Thr Asp Leu Met Tyr Lys Gly Asp Ile His 
        35                  40                  45              


Tyr Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu 
    50                  55                  60                  


Asn Leu Val Gln Gly Asn Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ser 
65                  70                  75                  80  


Asn Glu Gly Tyr Phe Asn Ser Ser Val Pro Val Gly Asp Arg Met Val 
                85                  90                  95      


Thr Glu Ile Glu Arg Val Thr Glu Pro Ile Ile Ser Asn Lys Tyr Trp 
            100                 105                 110         


Gly Asn Pro Glu Phe Val Leu Gly Asn Ile Lys Glu His Ile Ile Arg 
        115                 120                 125             


Asn Asp Lys Thr Asn Glu Met Tyr Gly Gln Phe Tyr Trp Ile Arg Asp 
    130                 135                 140                 


Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Asp Asn 
145                 150                 155                 160 


Val Asn Asn Tyr Asn Leu Trp Tyr Val Arg Thr Ser Lys Pro Glu Leu 
                165                 170                 175     


Lys Glu Phe Lys Ala Ser Ser Gly Lys Lys Asp Asp Pro Val Lys Phe 
            180                 185                 190         


Ile Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp 
        195                 200                 205             


Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ser Glu Ala Gly 
    210                 215                 220                 


Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile Ile Lys Asn Gly Glu 
225                 230                 235                 240 


Thr Val His His Gln Gly Asn Tyr Leu Arg Ser Asn Pro Gln Lys Asn 
                245                 250                 255     


Asn Asp Lys Pro Asn Glu Gly Asp Ala Gly Tyr Phe Ser Lys Glu Gly 
            260                 265                 270         


Ile Pro Phe Tyr Pro Gln Glu Cys Gly Arg Tyr Thr Ala Lys Leu Lys 
        275                 280                 285             


Leu Ile Asp Ala Val Gln Arg Glu Ser Thr Glu Lys Val Val Asp Phe 
    290                 295                 300                 


Val Val Asp Gly Ser Cys Gly Thr Gln Val Pro Pro Thr Thr Asp Pro 
305                 310                 315                 320 


Val Asp Gly Glu Phe Asn Tyr Lys Ile Asp Tyr Ser Ala Asp Arg Ile 
                325                 330                 335     


Glu Gly Glu Thr Ala Arg Lys Asp Lys Glu Ile Lys Thr Arg Val Asp 
            340                 345                 350         


Val Ser Arg Ala Ser Phe Lys Glu Glu His Asp Gln Tyr Arg Ala Lys 
        355                 360                 365             


Leu Asp Glu Glu Phe Lys Lys Tyr Gln Lys Glu Val Asp Ala Tyr Ile 
    370                 375                 380                 


Ser Glu Arg Asp Ser Ala Gln Asp Ser Leu Asn Tyr Cys Arg Arg Asn 
385                 390                 395                 400 


Pro Ile Arg Glu Glu Asp Glu Lys Gly Gly Val His Tyr Arg Asp Arg 
                405                 410                 415     


Asp Cys Ser Trp Glu Glu Asn Asn Leu Asp Asn Val Val Ser Lys Leu 
            420                 425                 430         


Glu Lys Ala Lys Gln Asn Arg Glu Lys Leu Ser Lys Lys Leu Gly Asp 
        435                 440                 445             


Phe Asp Lys Leu Asn Ala Gln Tyr His Asn Pro Glu Val Thr Val Ile 
    450                 455                 460                 


Leu Lys His Asn Gly Lys Lys Val Glu Ser Lys Thr Val Arg Leu Lys 
465                 470                 475                 480 


Glu Gly Glu Lys Lys Thr Val Phe Phe Asn Trp Glu His Lys Gly Lys 
                485                 490                 495     


Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala Asp Glu Asp Gly Ser Arg 
            500                 505                 510         


Leu Asp Ile Lys Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala 
        515                 520                 525             


Ile Tyr Glu Pro Ser Gln Glu Lys Ala Met Cys Gly Ala Thr Ser Val 
    530                 535                 540                 


Lys Gly Val Val Glu Thr Val Ser Asn Arg Val Ser Val Glu Asp Thr 
545                 550                 555                 560 


Val Gly Glu Met Tyr His Glu Thr Leu Thr Gly Ser Ile Asp Lys Leu 
                565                 570                 575     


Val Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Thr Tyr Glu Leu Asp 
            580                 585                 590         


Gly Lys Tyr Thr Asn Asn Trp Asp Gln Asn Tyr Gln Gly Val Phe Thr 
        595                 600                 605             


Val Ala Thr Ala Lys Tyr Pro Phe Ala Asp Glu Gly Leu Lys Leu Asn 
    610                 615                 620                 


Gln Asp Leu Glu Lys Lys Glu Ile Lys Asp Asn Thr Ser Lys Phe Ile 
625                 630                 635                 640 


Pro Lys Asn Met Tyr Leu Ser Glu Lys Thr Gly Tyr Val Phe Asp Ser 
                645                 650                 655     


Lys Arg Pro Ile Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile 
            660                 665                 670         


Asp Gly Gly His Lys Trp Tyr Ala Pro Met Lys Thr Lys Asp Gly Lys 
        675                 680                 685             


Tyr Ser Phe Lys Val Glu Thr Lys Pro Thr Gly Ile Asn Glu Met Ser 
    690                 695                 700                 


Leu Cys Met Thr Glu Glu Val Glu Ile Lys Gly Val Ala Tyr Asp Asp 
705                 710                 715                 720 


Phe Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser 
                725                 730                 735     


Gly Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu 
            740                 745                 750         


Thr Asp Trp Tyr Tyr Met Lys Asn Gly Asn Lys Asn Lys Ile 
        755                 760                 765     


<210> 5
<211> 18
<212> RNA
<213> Bacillus sp.

<400> 5
guugaacaau aacauaag                                                     18


<210> 6
<211> 16
<212> RNA
<213> Bacillus sp.

<400> 6
guugaacaau aacaua                                                       16


<210> 7
<211> 79
<212> RNA
<213> Bacillus sp.

<400> 7
cuuaauauua uauuuaauaa agaugcggaa aggacacacc uaacguacca gacuauggua       60

uagguguguc cuuuuugug                                                    79


<210> 8
<211> 97
<212> RNA
<213> Bacillus sp.

<400> 8
uguuaugaua uauuuaaaug aauauaugaa uuuaaaauuu acgugaagga cacaccuuac       60

guaccauucc aacgguacag guguguccuu uuuuugu                                97


<210> 9
<211> 130
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(29)
<223> a, c, u, g, unknown or other

<400> 9
nnnnnnnnnn nnnnnnnnnn nnnnnnnnng uugaacaaua acauaagaaa gcuuaauauu       60

auauuuaaua aagaugcgga aaggacacac cuaacguacc agacuauggu auaggugugu      120

ccuuuuugug                                                             130


<210> 10
<211> 146
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (1)..(29)
<223> a, c, u, g, unknown or other

<400> 10
nnnnnnnnnn nnnnnnnnnn nnnnnnnnng uugaacaaua acauaaaagu guuaugauau       60

auuuaaauga auauaugaau uuaaaauuua cgugaaggac acaccuuacg uaccauucca      120

acgguacagg uguguccuuu uuuugu                                           146


<210> 11
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 11
atcataatct gtattcctcc ttatgcttta cgcttt                                 36


<210> 12
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 12
atcataatct gtattcctcc ttatgcttta tgtcca                                 36


<210> 13
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 13
ctctatca                                                                 8


<210> 14
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 14
tggaatactg tcactaggag gtgttgtgac gctatg                                 36


<210> 15
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
tggaatactg tcactaggag gtgttgtgac gctatg                                 36


<210> 16
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 16
aaacctca                                                                 8


<210> 17
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 17
caagttgatt taagtaaatt agattttgaa gttattt                                37


<210> 18
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 18
caagttgatt taagtaaatt agattttgaa gttattt                                37


<210> 19
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
acctttca                                                                 8


<210> 20
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 20
attcagaggt ggtcatcatt aatgaatgcg ttaat                                  35


<210> 21
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 21
attcagaggt ggtcatcatt aatgaatgcg ttaat                                  35


<210> 22
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 22
ttgtatca                                                                 8


<210> 23
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 23
tccaaaggcg ctaaaattcc gatcggcaca ttata                                  35


<210> 24
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 24
tccaaaggcg ctaaaattcc gatcggcaca ttata                                  35


<210> 25
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 25
caacatca                                                                 8


<210> 26
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 26
tctactgaaa catataacgt tatgtttgat cctga                                  35


<210> 27
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 27
tctactgaaa catataacgt tatgtttgat cctga                                  35


<210> 28
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 28
gcttctca                                                                 8


<210> 29
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 29
ttttacattt acagaaagtg aagtagcttt aataga                                 36


<210> 30
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 30
ttttacattt acagaaagtg aagtagcttt aataga                                 36


<210> 31
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 31
caatttca                                                                 8


<210> 32
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 32
gtaataacat ctgcctctag tgatttgttt ttctt                                  35


<210> 33
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 33
gtaataacat ctgcctctag tgatttgttt ttctt                                  35


<210> 34
<211> 8
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 34
gtgcttca                                                                 8


<210> 35
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 35
tca                                                                      3


<210> 36
<211> 3
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 36
tga                                                                      3


<210> 37
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 37
gagcggacag cagcttccta tatctcgtac                                        30


<210> 38
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 38
ccatgatata gacgttgtgg ctgttgtagt                                        30


<210> 39
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Met Lys Leu Lys Arg Gly Leu Leu Val Leu Cys Thr Ser Thr 
            20                  25                  30          


Ala Leu Ile Tyr Pro Ser Ile Val Asn Ala Lys Asn Asn Asp Val Pro 
        35                  40                  45              


Phe Tyr Asp Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln 
    50                  55                  60                  


Leu Pro Gly Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu 
65                  70                  75                  80  


Ser Leu Tyr Arg Ala Asp Ile His Phe Pro Ala Val Tyr Asn Gly Ser 
                85                  90                  95      


Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Ala Glu Asp Ser 
            100                 105                 110         


Ser Glu Pro Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser 
        115                 120                 125             


Val Pro Ala Gly Asp Arg Met Val Thr Glu Val Glu Arg Ile Asn Lys 
    130                 135                 140                 


Tyr Val Ile Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp 
145                 150                 155                 160 


Asn Ile Asp Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu 
                165                 170                 175     


Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr 
            180                 185                 190         


Ala Gly Ala Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr 
        195                 200                 205             


Val Arg Thr Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser 
    210                 215                 220                 


Thr Lys Asp Val Pro Val Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val 
225                 230                 235                 240 


Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val 
                245                 250                 255     


Asn Pro Tyr Gln Ala Ala Ala Gly Glu Arg Asn Arg Val Lys Trp Met 
            260                 265                 270         


Leu Asp Ile Thr Lys Asp Gly Glu Thr Val His His Gln Glu Asn Tyr 
        275                 280                 285             


Leu Arg Ser Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp 
    290                 295                 300                 


Ala Gly Lys Phe Val Lys Asp Asp Val Lys Trp Gln Pro Gln Met Cys 
305                 310                 315                 320 


Gly Gln Tyr Thr Ala Lys Ile Lys Val Leu Asp Ala Val Gln Arg Glu 
                325                 330                 335     


Ser Asn Glu Lys Asn Val Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn 
            340                 345                 350         


Glu Val Thr Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr 
        355                 360                 365             


Ile Ile Asp Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu 
    370                 375                 380                 


Gly Lys Asn Ile Lys Thr Arg Val Asp Val Ser Arg Asp Asn Phe Lys 
385                 390                 395                 400 


Pro Glu Arg Asp Gln Tyr Arg Val Lys Val Asn Asn Asn Ile Asn Lys 
                405                 410                 415     


Ser Gln Gln Glu Val Asn Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln 
            420                 425                 430         


Ser Ser Leu Ser Tyr Cys Arg Arg Asn Pro Ile His Glu Val Asp Ala 
        435                 440                 445             


Glu Gly Lys Asp His Tyr Tyr Asp Arg Asp Cys Ser Trp Glu Glu Asn 
    450                 455                 460                 


Lys Leu Asp Ser Ala Ala Ser Lys Leu Asp Asn Ala Arg Gln Lys Phe 
465                 470                 475                 480 


Glu Lys Glu Lys Asn Lys Leu Lys Lys Leu Asp Val Leu Glu Glu Lys 
                485                 490                 495     


Tyr Thr Asn Pro Glu Thr Val Val Val Leu Lys His Asn Gly Gln Gln 
            500                 505                 510         


Val Ala Leu Gln Lys Val Arg Leu Thr Glu Gly Glu Lys Lys Thr Leu 
        515                 520                 525             


Asn Leu Asp Trp Gln His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile 
    530                 535                 540                 


Asn Pro Ala Gly Asn Arg Ile Asp Ile Glu Glu Thr Thr Tyr Lys Asn 
545                 550                 555                 560 


Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro Ser Lys Glu Lys Ala Met 
                565                 570                 575     


Cys Gly Val Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Glu Arg 
            580                 585                 590         


Val Ser Lys Glu Asp Ile Thr Gly Glu Met Tyr Tyr Glu Thr Leu Thr 
        595                 600                 605             


Gly Ser Ile Asp Asn Leu Ala Pro Ser Lys Leu His Ser Gly Tyr Gly 
    610                 615                 620                 


Phe Ser Tyr Glu Val Asn Gly Lys Tyr Lys Asn Asp Trp Asn Ala Asn 
625                 630                 635                 640 


Tyr Pro Gly Val Phe Thr Ala Ala Lys Ala Gln Tyr Pro Phe Ala Asp 
                645                 650                 655     


Glu Gly Leu Lys Ser Thr Gln Asp Leu Glu Lys Lys Glu Leu Lys Asp 
            660                 665                 670         


Asn Thr Ala Lys Phe Leu Pro Lys Asn Met Tyr Leu Ser Glu Ala Thr 
        675                 680                 685             


Gly His Val Phe Asp Ser Lys Arg Pro Thr Lys Ser Leu Tyr Trp Asp 
    690                 695                 700                 


Gly Gln Glu Lys Ile Ile Asp Gly Gly Gln Lys Trp Tyr Ser Pro Leu 
705                 710                 715                 720 


Lys Thr Lys Asp Gly Val Tyr Thr Phe Asn Val Glu Thr Ala Pro Ala 
                725                 730                 735     


Gly Ile Asn Glu Met Ser Leu Cys Leu Thr Glu Gln Val Glu Ile Lys 
            740                 745                 750         


Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp 
        755                 760                 765             


Pro Phe Pro Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu 
    770                 775                 780                 


Glu Leu Leu His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Thr Gly Lys 
785                 790                 795                 800 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
                805                 810                 815     


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
            820                 825                 830         


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
        835                 840                 845             


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
    850                 855                 860                 


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
865                 870                 875                 880 


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
                885                 890                 895     


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
            900                 905                 910         


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
        915                 920                 925             


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
    930                 935                 940                 


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
945                 950                 955                 960 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
                965                 970                 975     


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
            980                 985                 990         


Ala Gly Thr Leu Thr Leu Glu Glu  Val Arg Arg Lys Phe  Asn Asn Gly 
        995                 1000                 1005             


Glu Ile  Asn Phe Gly Gly Ser  Gly Ser Gly Ser Gly  Ser Gly Ser 
    1010                 1015                 1020             


Ile Thr  Arg Thr Thr Asn Pro  Arg Asn Val Val Pro  Lys Ile Tyr 
    1025                 1030                 1035             


Met Ser  Ala Gly Ser Ile Pro  Leu Thr Thr His Ile  Thr Asn Ser 
    1040                 1045                 1050             


Ile Gln  Pro Thr Leu Trp Thr  Ile Gly Ser Ile Asn  Gly Val Ala 
    1055                 1060                 1065             


Pro Leu  Ala Lys Ser Ile Lys  Leu Gly Ile Pro Val  Thr Gly Ser 
    1070                 1075                 1080             


Ala Tyr  Thr Asp Gln Thr Thr  Ala Met Val Arg Lys  Lys Val Ser 
    1085                 1090                 1095             


Val Phe  Met Gly Ser Gly Ser  Gly Ser Gly Ser Ser  Gln Leu Val 
    1100                 1105                 1110             


Lys Ser  Glu Leu Glu Glu Lys  Lys Ser Glu Leu Arg  His Lys Leu 
    1115                 1120                 1125             


Lys Tyr  Val Pro His Glu Tyr  Ile Glu Leu Ile Glu  Ile Ala Arg 
    1130                 1135                 1140             


Asn Ser  Thr Gln Asp Arg Ile  Leu Glu Met Lys Val  Met Glu Phe 
    1145                 1150                 1155             


Phe Met  Lys Val Tyr Gly Tyr  Arg Gly Lys His Leu  Gly Gly Ser 
    1160                 1165                 1170             


Arg Lys  Pro Asp Gly Ala Ile  Tyr Thr Val Gly Ser  Pro Ile Asp 
    1175                 1180                 1185             


Tyr Gly  Val Ile Val Asp Thr  Lys Ala Tyr Ser Gly  Gly Tyr Asn 
    1190                 1195                 1200             


Leu Pro  Ile Gly Gln Ala Asp  Glu Met Gln Arg Tyr  Val Glu Glu 
    1205                 1210                 1215             


Asn Gln  Thr Arg Asn Lys His  Ile Asn Pro Asn Glu  Trp Trp Lys 
    1220                 1225                 1230             


Val Tyr  Pro Ser Ser Val Thr  Glu Phe Lys Phe Leu  Phe Val Ser 
    1235                 1240                 1245             


Gly His  Phe Lys Gly Asn Tyr  Lys Ala Gln Leu Thr  Arg Leu Asn 
    1250                 1255                 1260             


His Ile  Thr Asn Cys Asn Gly  Ala Val Leu Ser Val  Glu Glu Leu 
    1265                 1270                 1275             


Leu Ile  Gly Gly Glu Met Ile  Lys Ala Gly Thr Leu  Thr Leu Glu 
    1280                 1285                 1290             


Glu Val  Arg Arg Lys Phe Asn  Asn Gly Glu Ile Asn  Phe Pro Lys 
    1295                 1300                 1305             


Lys Lys  Arg Lys Val Glu Asn  Leu Tyr Phe Gln Ser  Gly Ser His 
    1310                 1315                 1320             


His His  His His His His His  His His 
    1325                 1330         


<210> 40
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 40
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
            20                  25                  30          


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
        35                  40                  45              


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
    50                  55                  60                  


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
65                  70                  75                  80  


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
                85                  90                  95      


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
            100                 105                 110         


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
        115                 120                 125             


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
    130                 135                 140                 


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
145                 150                 155                 160 


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
                165                 170                 175     


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
            180                 185                 190         


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
        195                 200                 205             


Asn Gly Glu Ile Asn Phe Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Ser Ile Thr Arg Thr Thr Asn Pro Arg Asn Val Val Pro Lys Ile Tyr 
225                 230                 235                 240 


Met Ser Ala Gly Ser Ile Pro Leu Thr Thr His Ile Thr Asn Ser Ile 
                245                 250                 255     


Gln Pro Thr Leu Trp Thr Ile Gly Ser Ile Asn Gly Val Ala Pro Leu 
            260                 265                 270         


Ala Lys Ser Ile Lys Leu Gly Ile Pro Val Thr Gly Ser Ala Tyr Thr 
        275                 280                 285             


Asp Gln Thr Thr Ala Met Val Arg Lys Lys Val Ser Val Phe Met Gly 
    290                 295                 300                 


Ser Gly Ser Gly Ser Gly Ser Ser Gln Leu Val Lys Ser Glu Leu Glu 
305                 310                 315                 320 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
                325                 330                 335     


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
            340                 345                 350         


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
        355                 360                 365             


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
    370                 375                 380                 


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
385                 390                 395                 400 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
                405                 410                 415     


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
            420                 425                 430         


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
        435                 440                 445             


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
    450                 455                 460                 


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
465                 470                 475                 480 


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
                485                 490                 495     


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly Ser Glu 
            500                 505                 510         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Lys Leu Lys 
        515                 520                 525             


Arg Gly Leu Leu Val Leu Cys Thr Ser Thr Ala Leu Ile Tyr Pro Ser 
    530                 535                 540                 


Ile Val Asn Ala Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn 
545                 550                 555                 560 


Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe 
                565                 570                 575     


Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp 
            580                 585                 590         


Ile His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro 
        595                 600                 605             


Lys Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg 
    610                 615                 620                 


Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg 
625                 630                 635                 640 


Met Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys 
                645                 650                 655     


Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser 
            660                 665                 670         


Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile 
        675                 680                 685             


Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val 
    690                 695                 700                 


Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro 
705                 710                 715                 720 


Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val 
                725                 730                 735     


Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr 
            740                 745                 750         


Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala 
        755                 760                 765             


Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp 
    770                 775                 780                 


Gly Glu Thr Val His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln 
785                 790                 795                 800 


Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys 
                805                 810                 815     


Asp Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys 
            820                 825                 830         


Ile Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val 
        835                 840                 845             


Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro 
    850                 855                 860                 


Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala 
865                 870                 875                 880 


Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr 
                885                 890                 895     


Arg Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr 
            900                 905                 910         


Arg Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn 
        915                 920                 925             


Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys 
    930                 935                 940                 


Arg Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr 
945                 950                 955                 960 


Tyr Asp Arg Asp Cys Ser Trp Glu Glu Asn Lys Leu Asp Ser Ala Ala 
                965                 970                 975     


Ser Lys Leu Asp Asn Ala Arg Gln Lys Phe Glu Lys Glu Lys Asn Lys 
            980                 985                 990         


Leu Lys Lys Leu Asp Val Leu Glu  Glu Lys Tyr Thr Asn  Pro Glu Thr 
        995                 1000                 1005             


Val Val  Val Leu Lys His Asn  Gly Gln Gln Val Ala  Leu Gln Lys 
    1010                 1015                 1020             


Val Arg  Leu Thr Glu Gly Glu  Lys Lys Thr Leu Asn  Leu Asp Trp 
    1025                 1030                 1035             


Gln His  Lys Gly Lys Gly Thr  Ile Gln Ala Glu Ile  Asn Pro Ala 
    1040                 1045                 1050             


Gly Asn  Arg Ile Asp Ile Glu  Glu Thr Thr Tyr Lys  Asn Asn Pro 
    1055                 1060                 1065             


Ile Lys  Thr Ala Ile Tyr Glu  Pro Ser Lys Glu Lys  Ala Met Cys 
    1070                 1075                 1080             


Gly Val  Thr Ser Val Lys Gly  Val Val Glu Thr Val  Ser Glu Arg 
    1085                 1090                 1095             


Val Ser  Lys Glu Asp Ile Thr  Gly Glu Met Tyr Tyr  Glu Thr Leu 
    1100                 1105                 1110             


Thr Gly  Ser Ile Asp Asn Leu  Ala Pro Ser Lys Leu  His Ser Gly 
    1115                 1120                 1125             


Tyr Gly  Phe Ser Tyr Glu Val  Asn Gly Lys Tyr Lys  Asn Asp Trp 
    1130                 1135                 1140             


Asn Ala  Asn Tyr Pro Gly Val  Phe Thr Ala Ala Lys  Ala Gln Tyr 
    1145                 1150                 1155             


Pro Phe  Ala Asp Glu Gly Leu  Lys Ser Thr Gln Asp  Leu Glu Lys 
    1160                 1165                 1170             


Lys Glu  Leu Lys Asp Asn Thr  Ala Lys Phe Leu Pro  Lys Asn Met 
    1175                 1180                 1185             


Tyr Leu  Ser Glu Ala Thr Gly  His Val Phe Asp Ser  Lys Arg Pro 
    1190                 1195                 1200             


Thr Lys  Ser Leu Tyr Trp Asp  Gly Gln Glu Lys Ile  Ile Asp Gly 
    1205                 1210                 1215             


Gly Gln  Lys Trp Tyr Ser Pro  Leu Lys Thr Lys Asp  Gly Val Tyr 
    1220                 1225                 1230             


Thr Phe  Asn Val Glu Thr Ala  Pro Ala Gly Ile Asn  Glu Met Ser 
    1235                 1240                 1245             


Leu Cys  Leu Thr Glu Gln Val  Glu Ile Lys Gly Val  Ala Tyr Asp 
    1250                 1255                 1260             


Asp Phe  Ile Lys Arg Arg Val  Phe Pro Asp Asp Pro  Phe Pro Gly 
    1265                 1270                 1275             


Gly Ser  Gly Val Gly Trp Asn  Trp Val Gly Lys Glu  Glu Leu Leu 
    1280                 1285                 1290             


His Lys  Leu Thr Asp Trp Tyr  Tyr Met Lys Thr Gly  Lys Pro Lys 
    1295                 1300                 1305             


Lys Lys  Arg Lys Val Glu Asn  Leu Tyr Phe Gln Ser  Gly Ser His 
    1310                 1315                 1320             


His His  His His His His His  His His 
    1325                 1330         


<210> 41
<211> 1309
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Met Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn Asp 
            20                  25                  30          


Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe Arg 
        35                  40                  45              


Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp Ile 
    50                  55                  60                  


His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys 
65                  70                  75                  80  


Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg Ile 
                85                  90                  95      


Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg Met 
            100                 105                 110         


Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys Tyr 
        115                 120                 125             


Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser Ile 
    130                 135                 140                 


Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile Arg 
145                 150                 155                 160 


Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Glu 
                165                 170                 175     


Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro Glu 
            180                 185                 190         


Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val Lys 
        195                 200                 205             


Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn 
    210                 215                 220                 


Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala Ala 
225                 230                 235                 240 


Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp Gly 
                245                 250                 255     


Glu Thr Val His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln Lys 
            260                 265                 270         


Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys Asp 
        275                 280                 285             


Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys Ile 
    290                 295                 300                 


Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val Asp 
305                 310                 315                 320 


Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro Asp 
                325                 330                 335     


Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala Asp 
            340                 345                 350         


Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr Arg 
        355                 360                 365             


Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr Arg 
    370                 375                 380                 


Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn Ser 
385                 390                 395                 400 


Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys Arg 
                405                 410                 415     


Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr Tyr 
            420                 425                 430         


Asp Arg Asp Cys Ser Trp Glu Glu Asn Lys Leu Asp Ser Ala Ala Ser 
        435                 440                 445             


Lys Leu Asp Asn Ala Arg Gln Lys Phe Glu Lys Glu Lys Asn Lys Leu 
    450                 455                 460                 


Lys Lys Leu Asp Val Leu Glu Glu Lys Tyr Thr Asn Pro Glu Thr Val 
465                 470                 475                 480 


Val Val Leu Lys His Asn Gly Gln Gln Val Ala Leu Gln Lys Val Arg 
                485                 490                 495     


Leu Thr Glu Gly Glu Lys Lys Thr Leu Asn Leu Asp Trp Gln His Lys 
            500                 505                 510         


Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala Gly Asn Arg Ile 
        515                 520                 525             


Asp Ile Glu Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile 
    530                 535                 540                 


Tyr Glu Pro Ser Lys Glu Lys Ala Met Cys Gly Val Thr Ser Val Lys 
545                 550                 555                 560 


Gly Val Val Glu Thr Val Ser Glu Arg Val Ser Lys Glu Asp Ile Thr 
                565                 570                 575     


Gly Glu Met Tyr Tyr Glu Thr Leu Thr Gly Ser Ile Asp Asn Leu Ala 
            580                 585                 590         


Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Ser Tyr Glu Val Asn Gly 
        595                 600                 605             


Lys Tyr Lys Asn Asp Trp Asn Ala Asn Tyr Pro Gly Val Phe Thr Ala 
    610                 615                 620                 


Ala Lys Ala Gln Tyr Pro Phe Ala Asp Glu Gly Leu Lys Ser Thr Gln 
625                 630                 635                 640 


Asp Leu Glu Lys Lys Glu Leu Lys Asp Asn Thr Ala Lys Phe Leu Pro 
                645                 650                 655     


Lys Asn Met Tyr Leu Ser Glu Ala Thr Gly His Val Phe Asp Ser Lys 
            660                 665                 670         


Arg Pro Thr Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp 
        675                 680                 685             


Gly Gly Gln Lys Trp Tyr Ser Pro Leu Lys Thr Lys Asp Gly Val Tyr 
    690                 695                 700                 


Thr Phe Asn Val Glu Thr Ala Pro Ala Gly Ile Asn Glu Met Ser Leu 
705                 710                 715                 720 


Cys Leu Thr Glu Gln Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe 
                725                 730                 735     


Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly 
            740                 745                 750         


Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr 
        755                 760                 765             


Asp Trp Tyr Tyr Met Lys Thr Gly Lys Ser Gly Ser Glu Thr Pro Gly 
    770                 775                 780                 


Thr Ser Glu Ser Ala Thr Pro Glu Ser Gln Leu Val Lys Ser Glu Leu 
785                 790                 795                 800 


Glu Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His 
                805                 810                 815     


Glu Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg 
            820                 825                 830         


Ile Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr 
        835                 840                 845             


Arg Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr 
    850                 855                 860                 


Thr Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala 
865                 870                 875                 880 


Tyr Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln 
                885                 890                 895     


Arg Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn 
            900                 905                 910         


Glu Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu 
        915                 920                 925             


Phe Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg 
    930                 935                 940                 


Leu Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu 
945                 950                 955                 960 


Leu Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu 
                965                 970                 975     


Glu Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Gly Gly Ser 
            980                 985                 990         


Gly Ser Gly Ser Gly Ser Gly Ser  Ile Thr Arg Thr Thr  Asn Pro Arg 
        995                 1000                 1005             


Asn Val  Val Pro Lys Ile Tyr  Met Ser Ala Gly Ser  Ile Pro Leu 
    1010                 1015                 1020             


Thr Thr  His Ile Thr Asn Ser  Ile Gln Pro Thr Leu  Trp Thr Ile 
    1025                 1030                 1035             


Gly Ser  Ile Asn Gly Val Ala  Pro Leu Ala Lys Ser  Ile Lys Leu 
    1040                 1045                 1050             


Gly Ile  Pro Val Thr Gly Ser  Ala Tyr Thr Asp Gln  Thr Thr Ala 
    1055                 1060                 1065             


Met Val  Arg Lys Lys Val Ser  Val Phe Met Gly Ser  Gly Ser Gly 
    1070                 1075                 1080             


Ser Gly  Ser Ser Gln Leu Val  Lys Ser Glu Leu Glu  Glu Lys Lys 
    1085                 1090                 1095             


Ser Glu  Leu Arg His Lys Leu  Lys Tyr Val Pro His  Glu Tyr Ile 
    1100                 1105                 1110             


Glu Leu  Ile Glu Ile Ala Arg  Asn Ser Thr Gln Asp  Arg Ile Leu 
    1115                 1120                 1125             


Glu Met  Lys Val Met Glu Phe  Phe Met Lys Val Tyr  Gly Tyr Arg 
    1130                 1135                 1140             


Gly Lys  His Leu Gly Gly Ser  Arg Lys Pro Asp Gly  Ala Ile Tyr 
    1145                 1150                 1155             


Thr Val  Gly Ser Pro Ile Asp  Tyr Gly Val Ile Val  Asp Thr Lys 
    1160                 1165                 1170             


Ala Tyr  Ser Gly Gly Tyr Asn  Leu Pro Ile Gly Gln  Ala Asp Glu 
    1175                 1180                 1185             


Met Gln  Arg Tyr Val Glu Glu  Asn Gln Thr Arg Asn  Lys His Ile 
    1190                 1195                 1200             


Asn Pro  Asn Glu Trp Trp Lys  Val Tyr Pro Ser Ser  Val Thr Glu 
    1205                 1210                 1215             


Phe Lys  Phe Leu Phe Val Ser  Gly His Phe Lys Gly  Asn Tyr Lys 
    1220                 1225                 1230             


Ala Gln  Leu Thr Arg Leu Asn  His Ile Thr Asn Cys  Asn Gly Ala 
    1235                 1240                 1245             


Val Leu  Ser Val Glu Glu Leu  Leu Ile Gly Gly Glu  Met Ile Lys 
    1250                 1255                 1260             


Ala Gly  Thr Leu Thr Leu Glu  Glu Val Arg Arg Lys  Phe Asn Asn 
    1265                 1270                 1275             


Gly Glu  Ile Asn Phe Pro Lys  Lys Lys Arg Lys Val  Glu Asn Leu 
    1280                 1285                 1290             


Tyr Phe  Gln Ser Gly Ser His  His His His His His  His His His 
    1295                 1300                 1305             


His 
    


<210> 42
<211> 1309
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 42
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
            20                  25                  30          


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
        35                  40                  45              


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
    50                  55                  60                  


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
65                  70                  75                  80  


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
                85                  90                  95      


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
            100                 105                 110         


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
        115                 120                 125             


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
    130                 135                 140                 


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
145                 150                 155                 160 


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
                165                 170                 175     


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
            180                 185                 190         


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
        195                 200                 205             


Asn Gly Glu Ile Asn Phe Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Ser Ile Thr Arg Thr Thr Asn Pro Arg Asn Val Val Pro Lys Ile Tyr 
225                 230                 235                 240 


Met Ser Ala Gly Ser Ile Pro Leu Thr Thr His Ile Thr Asn Ser Ile 
                245                 250                 255     


Gln Pro Thr Leu Trp Thr Ile Gly Ser Ile Asn Gly Val Ala Pro Leu 
            260                 265                 270         


Ala Lys Ser Ile Lys Leu Gly Ile Pro Val Thr Gly Ser Ala Tyr Thr 
        275                 280                 285             


Asp Gln Thr Thr Ala Met Val Arg Lys Lys Val Ser Val Phe Met Gly 
    290                 295                 300                 


Ser Gly Ser Gly Ser Gly Ser Ser Gln Leu Val Lys Ser Glu Leu Glu 
305                 310                 315                 320 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
                325                 330                 335     


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
            340                 345                 350         


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
        355                 360                 365             


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
    370                 375                 380                 


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
385                 390                 395                 400 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
                405                 410                 415     


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
            420                 425                 430         


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
        435                 440                 445             


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
    450                 455                 460                 


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
465                 470                 475                 480 


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
                485                 490                 495     


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly Ser Glu 
            500                 505                 510         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Lys Asn Asn 
        515                 520                 525             


Asp Val Pro Phe Tyr Asp Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys 
    530                 535                 540                 


Tyr Leu Gln Leu Pro Gly Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala 
545                 550                 555                 560 


Ser Lys Glu Ser Leu Tyr Arg Ala Asp Ile His Phe Pro Ala Val Tyr 
                565                 570                 575     


Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Ala 
            580                 585                 590         


Glu Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu 
        595                 600                 605             


Asn Gly Ser Val Pro Ala Gly Asp Arg Met Val Thr Glu Val Glu Arg 
    610                 615                 620                 


Ile Asn Lys Tyr Val Ile Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe 
625                 630                 635                 640 


Val Leu Asp Asn Ile Asp Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr 
                645                 650                 655     


Lys Glu Leu Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser 
            660                 665                 670         


Gly Gly Tyr Ala Gly Ala Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser 
        675                 680                 685             


Leu Trp Tyr Val Arg Thr Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala 
    690                 695                 700                 


Ser Ser Ser Thr Lys Asp Val Pro Val Lys Phe Thr Phe Asn Gly Phe 
705                 710                 715                 720 


Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly 
                725                 730                 735     


Thr Thr Val Asn Pro Tyr Gln Ala Ala Ala Gly Glu Arg Asn Arg Val 
            740                 745                 750         


Lys Trp Met Leu Asp Ile Thr Lys Asp Gly Glu Thr Val His His Gln 
        755                 760                 765             


Glu Asn Tyr Leu Arg Ser Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn 
    770                 775                 780                 


Glu Gly Asp Ala Gly Lys Phe Val Lys Asp Asp Val Lys Trp Gln Pro 
785                 790                 795                 800 


Gln Met Cys Gly Gln Tyr Thr Ala Lys Ile Lys Val Leu Asp Ala Val 
                805                 810                 815     


Gln Arg Glu Ser Asn Glu Lys Asn Val Asp Phe Thr Ile Asp Gly Asn 
            820                 825                 830         


Cys Gly Asn Glu Val Thr Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp 
        835                 840                 845             


Phe Lys Tyr Ile Ile Asp Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr 
    850                 855                 860                 


Ala Arg Glu Gly Lys Asn Ile Lys Thr Arg Val Asp Val Ser Arg Asp 
865                 870                 875                 880 


Asn Phe Lys Pro Glu Arg Asp Gln Tyr Arg Val Lys Val Asn Asn Asn 
                885                 890                 895     


Ile Asn Lys Ser Gln Gln Glu Val Asn Ser Ser Glu Ser Glu Arg Asp 
            900                 905                 910         


Ser Ala Gln Ser Ser Leu Ser Tyr Cys Arg Arg Asn Pro Ile His Glu 
        915                 920                 925             


Val Asp Ala Glu Gly Lys Asp His Tyr Tyr Asp Arg Asp Cys Ser Trp 
    930                 935                 940                 


Glu Glu Asn Lys Leu Asp Ser Ala Ala Ser Lys Leu Asp Asn Ala Arg 
945                 950                 955                 960 


Gln Lys Phe Glu Lys Glu Lys Asn Lys Leu Lys Lys Leu Asp Val Leu 
                965                 970                 975     


Glu Glu Lys Tyr Thr Asn Pro Glu Thr Val Val Val Leu Lys His Asn 
            980                 985                 990         


Gly Gln Gln Val Ala Leu Gln Lys  Val Arg Leu Thr Glu  Gly Glu Lys 
        995                 1000                 1005             


Lys Thr  Leu Asn Leu Asp Trp  Gln His Lys Gly Lys  Gly Thr Ile 
    1010                 1015                 1020             


Gln Ala  Glu Ile Asn Pro Ala  Gly Asn Arg Ile Asp  Ile Glu Glu 
    1025                 1030                 1035             


Thr Thr  Tyr Lys Asn Asn Pro  Ile Lys Thr Ala Ile  Tyr Glu Pro 
    1040                 1045                 1050             


Ser Lys  Glu Lys Ala Met Cys  Gly Val Thr Ser Val  Lys Gly Val 
    1055                 1060                 1065             


Val Glu  Thr Val Ser Glu Arg  Val Ser Lys Glu Asp  Ile Thr Gly 
    1070                 1075                 1080             


Glu Met  Tyr Tyr Glu Thr Leu  Thr Gly Ser Ile Asp  Asn Leu Ala 
    1085                 1090                 1095             


Pro Ser  Lys Leu His Ser Gly  Tyr Gly Phe Ser Tyr  Glu Val Asn 
    1100                 1105                 1110             


Gly Lys  Tyr Lys Asn Asp Trp  Asn Ala Asn Tyr Pro  Gly Val Phe 
    1115                 1120                 1125             


Thr Ala  Ala Lys Ala Gln Tyr  Pro Phe Ala Asp Glu  Gly Leu Lys 
    1130                 1135                 1140             


Ser Thr  Gln Asp Leu Glu Lys  Lys Glu Leu Lys Asp  Asn Thr Ala 
    1145                 1150                 1155             


Lys Phe  Leu Pro Lys Asn Met  Tyr Leu Ser Glu Ala  Thr Gly His 
    1160                 1165                 1170             


Val Phe  Asp Ser Lys Arg Pro  Thr Lys Ser Leu Tyr  Trp Asp Gly 
    1175                 1180                 1185             


Gln Glu  Lys Ile Ile Asp Gly  Gly Gln Lys Trp Tyr  Ser Pro Leu 
    1190                 1195                 1200             


Lys Thr  Lys Asp Gly Val Tyr  Thr Phe Asn Val Glu  Thr Ala Pro 
    1205                 1210                 1215             


Ala Gly  Ile Asn Glu Met Ser  Leu Cys Leu Thr Glu  Gln Val Glu 
    1220                 1225                 1230             


Ile Lys  Gly Val Ala Tyr Asp  Asp Phe Ile Lys Arg  Arg Val Phe 
    1235                 1240                 1245             


Pro Asp  Asp Pro Phe Pro Gly  Gly Ser Gly Val Gly  Trp Asn Trp 
    1250                 1255                 1260             


Val Gly  Lys Glu Glu Leu Leu  His Lys Leu Thr Asp  Trp Tyr Tyr 
    1265                 1270                 1275             


Met Lys  Thr Gly Lys Pro Lys  Lys Lys Arg Lys Val  Glu Asn Leu 
    1280                 1285                 1290             


Tyr Phe  Gln Ser Gly Ser His  His His His His His  His His His 
    1295                 1300                 1305             


His 
    


<210> 43
<211> 1339
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Met Lys Phe Lys Lys Gly Ile Phe Val Leu Phe Thr Ser Val 
            20                  25                  30          


Leu Leu Ser Ala Pro Asn Ser Ala Asp Ala Lys Asn Asn Asp Val Pro 
        35                  40                  45              


Phe Tyr Asn Gly Asn Glu Asp Thr Phe Val Lys Ser Ala Gln Leu Gln 
    50                  55                  60                  


Met Pro Gly Lys Tyr Phe Arg Pro Gly Ser Tyr Ser Pro Gln Gly Thr 
65                  70                  75                  80  


Asp Leu Met Tyr Lys Gly Asp Ile His Tyr Pro Ala Val Tyr Asn Gly 
                85                  90                  95      


Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Gly Asn Asp 
            100                 105                 110         


Ser Ser Glu Pro Tyr Ile Arg Ile Ser Asn Glu Gly Tyr Phe Asn Ser 
        115                 120                 125             


Ser Val Pro Val Gly Asp Arg Met Val Thr Glu Ile Glu Arg Val Thr 
    130                 135                 140                 


Glu Pro Ile Ile Ser Asn Lys Tyr Trp Gly Asn Pro Glu Phe Val Leu 
145                 150                 155                 160 


Gly Asn Ile Lys Glu His Ile Ile Arg Asn Asp Lys Thr Asn Glu Met 
                165                 170                 175     


Tyr Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly 
            180                 185                 190         


Tyr Ala Gly Ala Gly Ala Val Asp Asn Val Asn Asn Tyr Asn Leu Trp 
        195                 200                 205             


Tyr Val Arg Thr Ser Lys Pro Glu Leu Lys Glu Phe Lys Ala Ser Ser 
    210                 215                 220                 


Gly Lys Lys Asp Asp Pro Val Lys Phe Ile Phe Asn Gly Phe Glu Tyr 
225                 230                 235                 240 


Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr 
                245                 250                 255     


Val Asn Pro Tyr Gln Ser Glu Ala Gly Glu Arg Asn Arg Val Lys Trp 
            260                 265                 270         


Met Leu Asp Ile Ile Lys Asn Gly Glu Thr Val His His Gln Gly Asn 
        275                 280                 285             


Tyr Leu Arg Ser Asn Pro Gln Lys Asn Asn Asp Lys Pro Asn Glu Gly 
    290                 295                 300                 


Asp Ala Gly Tyr Phe Ser Lys Glu Gly Ile Pro Phe Tyr Pro Gln Glu 
305                 310                 315                 320 


Cys Gly Arg Tyr Thr Ala Lys Leu Lys Leu Ile Asp Ala Val Gln Arg 
                325                 330                 335     


Glu Ser Thr Glu Lys Val Val Asp Phe Val Val Asp Gly Ser Cys Gly 
            340                 345                 350         


Thr Gln Val Pro Pro Thr Thr Asp Pro Val Asp Gly Glu Phe Asn Tyr 
        355                 360                 365             


Lys Ile Asp Tyr Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Lys 
    370                 375                 380                 


Asp Lys Glu Ile Lys Thr Arg Val Asp Val Ser Arg Ala Ser Phe Lys 
385                 390                 395                 400 


Glu Glu His Asp Gln Tyr Arg Ala Lys Leu Asp Glu Glu Phe Lys Lys 
                405                 410                 415     


Tyr Gln Lys Glu Val Asp Ala Tyr Ile Ser Glu Arg Asp Ser Ala Gln 
            420                 425                 430         


Asp Ser Leu Asn Tyr Cys Arg Arg Asn Pro Ile Arg Glu Glu Asp Glu 
        435                 440                 445             


Lys Gly Gly Val His Tyr Arg Asp Arg Asp Cys Ser Trp Glu Glu Asn 
    450                 455                 460                 


Asn Leu Asp Asn Val Val Ser Lys Leu Glu Lys Ala Lys Gln Asn Arg 
465                 470                 475                 480 


Glu Lys Leu Ser Lys Lys Leu Gly Asp Phe Asp Lys Leu Asn Ala Gln 
                485                 490                 495     


Tyr His Asn Pro Glu Val Thr Val Ile Leu Lys His Asn Gly Lys Lys 
            500                 505                 510         


Val Glu Ser Lys Thr Val Arg Leu Lys Glu Gly Glu Lys Lys Thr Val 
        515                 520                 525             


Phe Phe Asn Trp Glu His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile 
    530                 535                 540                 


Asn Pro Ala Asp Glu Asp Gly Ser Arg Leu Asp Ile Lys Glu Thr Thr 
545                 550                 555                 560 


Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro Ser Gln Glu 
                565                 570                 575     


Lys Ala Met Cys Gly Ala Thr Ser Val Lys Gly Val Val Glu Thr Val 
            580                 585                 590         


Ser Asn Arg Val Ser Val Glu Asp Thr Val Gly Glu Met Tyr His Glu 
        595                 600                 605             


Thr Leu Thr Gly Ser Ile Asp Lys Leu Val Pro Ser Lys Leu His Ser 
    610                 615                 620                 


Gly Tyr Gly Phe Thr Tyr Glu Leu Asp Gly Lys Tyr Thr Asn Asn Trp 
625                 630                 635                 640 


Asp Gln Asn Tyr Gln Gly Val Phe Thr Val Ala Thr Ala Lys Tyr Pro 
                645                 650                 655     


Phe Ala Asp Glu Gly Leu Lys Leu Asn Gln Asp Leu Glu Lys Lys Glu 
            660                 665                 670         


Ile Lys Asp Asn Thr Ser Lys Phe Ile Pro Lys Asn Met Tyr Leu Ser 
        675                 680                 685             


Glu Lys Thr Gly Tyr Val Phe Asp Ser Lys Arg Pro Ile Lys Ser Leu 
    690                 695                 700                 


Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp Gly Gly His Lys Trp Tyr 
705                 710                 715                 720 


Ala Pro Met Lys Thr Lys Asp Gly Lys Tyr Ser Phe Lys Val Glu Thr 
                725                 730                 735     


Lys Pro Thr Gly Ile Asn Glu Met Ser Leu Cys Met Thr Glu Glu Val 
            740                 745                 750         


Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe 
        755                 760                 765             


Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly Val Gly Trp Asn Trp Val 
    770                 775                 780                 


Gly Lys Glu Glu Leu Leu His Lys Leu Thr Asp Trp Tyr Tyr Met Lys 
785                 790                 795                 800 


Asn Gly Asn Lys Asn Lys Ile Ser Gly Ser Glu Thr Pro Gly Thr Ser 
                805                 810                 815     


Glu Ser Ala Thr Pro Glu Ser Gln Leu Val Lys Ser Glu Leu Glu Glu 
            820                 825                 830         


Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr 
        835                 840                 845             


Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu 
    850                 855                 860                 


Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly 
865                 870                 875                 880 


Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val 
                885                 890                 895     


Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser 
            900                 905                 910         


Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr 
        915                 920                 925             


Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp 
    930                 935                 940                 


Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val 
945                 950                 955                 960 


Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn 
                965                 970                 975     


His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu 
            980                 985                 990         


Ile Gly Gly Glu Met Ile Lys Ala  Gly Thr Leu Thr Leu  Glu Glu Val 
        995                 1000                 1005             


Arg Arg  Lys Phe Asn Asn Gly  Glu Ile Asn Phe Gly  Gly Ser Gly 
    1010                 1015                 1020             


Ser Gly  Ser Gly Ser Gly Ser  Ile Thr Arg Thr Thr  Asn Pro Arg 
    1025                 1030                 1035             


Asn Val  Val Pro Lys Ile Tyr  Met Ser Ala Gly Ser  Ile Pro Leu 
    1040                 1045                 1050             


Thr Thr  His Ile Thr Asn Ser  Ile Gln Pro Thr Leu  Trp Thr Ile 
    1055                 1060                 1065             


Gly Ser  Ile Asn Gly Val Ala  Pro Leu Ala Lys Ser  Ile Lys Leu 
    1070                 1075                 1080             


Gly Ile  Pro Val Thr Gly Ser  Ala Tyr Thr Asp Gln  Thr Thr Ala 
    1085                 1090                 1095             


Met Val  Arg Lys Lys Val Ser  Val Phe Met Gly Ser  Gly Ser Gly 
    1100                 1105                 1110             


Ser Gly  Ser Ser Gln Leu Val  Lys Ser Glu Leu Glu  Glu Lys Lys 
    1115                 1120                 1125             


Ser Glu  Leu Arg His Lys Leu  Lys Tyr Val Pro His  Glu Tyr Ile 
    1130                 1135                 1140             


Glu Leu  Ile Glu Ile Ala Arg  Asn Ser Thr Gln Asp  Arg Ile Leu 
    1145                 1150                 1155             


Glu Met  Lys Val Met Glu Phe  Phe Met Lys Val Tyr  Gly Tyr Arg 
    1160                 1165                 1170             


Gly Lys  His Leu Gly Gly Ser  Arg Lys Pro Asp Gly  Ala Ile Tyr 
    1175                 1180                 1185             


Thr Val  Gly Ser Pro Ile Asp  Tyr Gly Val Ile Val  Asp Thr Lys 
    1190                 1195                 1200             


Ala Tyr  Ser Gly Gly Tyr Asn  Leu Pro Ile Gly Gln  Ala Asp Glu 
    1205                 1210                 1215             


Met Gln  Arg Tyr Val Glu Glu  Asn Gln Thr Arg Asn  Lys His Ile 
    1220                 1225                 1230             


Asn Pro  Asn Glu Trp Trp Lys  Val Tyr Pro Ser Ser  Val Thr Glu 
    1235                 1240                 1245             


Phe Lys  Phe Leu Phe Val Ser  Gly His Phe Lys Gly  Asn Tyr Lys 
    1250                 1255                 1260             


Ala Gln  Leu Thr Arg Leu Asn  His Ile Thr Asn Cys  Asn Gly Ala 
    1265                 1270                 1275             


Val Leu  Ser Val Glu Glu Leu  Leu Ile Gly Gly Glu  Met Ile Lys 
    1280                 1285                 1290             


Ala Gly  Thr Leu Thr Leu Glu  Glu Val Arg Arg Lys  Phe Asn Asn 
    1295                 1300                 1305             


Gly Glu  Ile Asn Phe Pro Lys  Lys Lys Arg Lys Val  Glu Asn Leu 
    1310                 1315                 1320             


Tyr Phe  Gln Ser Gly Ser His  His His His His His  His His His 
    1325                 1330                 1335             


His 
    


<210> 44
<211> 1332
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 44
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
            20                  25                  30          


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
        35                  40                  45              


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
    50                  55                  60                  


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
65                  70                  75                  80  


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
                85                  90                  95      


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
            100                 105                 110         


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
        115                 120                 125             


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
    130                 135                 140                 


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
145                 150                 155                 160 


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
                165                 170                 175     


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
            180                 185                 190         


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
        195                 200                 205             


Asn Gly Glu Ile Asn Phe Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Ser Ile Thr Arg Thr Thr Asn Pro Arg Asn Val Val Pro Lys Ile Tyr 
225                 230                 235                 240 


Met Ser Ala Gly Ser Ile Pro Leu Thr Thr His Ile Thr Asn Ser Ile 
                245                 250                 255     


Gln Pro Thr Leu Trp Thr Ile Gly Ser Ile Asn Gly Val Ala Pro Leu 
            260                 265                 270         


Ala Lys Ser Ile Lys Leu Gly Ile Pro Val Thr Gly Ser Ala Tyr Thr 
        275                 280                 285             


Asp Gln Thr Thr Ala Met Val Arg Lys Lys Val Ser Val Phe Met Gly 
    290                 295                 300                 


Ser Gly Ser Gly Ser Gly Ser Ser Gln Leu Val Lys Ser Glu Leu Glu 
305                 310                 315                 320 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
                325                 330                 335     


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
            340                 345                 350         


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
        355                 360                 365             


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
    370                 375                 380                 


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
385                 390                 395                 400 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
                405                 410                 415     


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
            420                 425                 430         


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
        435                 440                 445             


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
    450                 455                 460                 


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
465                 470                 475                 480 


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
                485                 490                 495     


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly Ser Glu 
            500                 505                 510         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Lys Leu Lys 
        515                 520                 525             


Arg Gly Leu Leu Val Leu Cys Thr Ser Thr Ala Leu Ile Tyr Pro Ser 
    530                 535                 540                 


Ile Val Asn Ala Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn 
545                 550                 555                 560 


Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe 
                565                 570                 575     


Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp 
            580                 585                 590         


Ile His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro 
        595                 600                 605             


Lys Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg 
    610                 615                 620                 


Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg 
625                 630                 635                 640 


Met Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys 
                645                 650                 655     


Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser 
            660                 665                 670         


Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile 
        675                 680                 685             


Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val 
    690                 695                 700                 


Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro 
705                 710                 715                 720 


Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val 
                725                 730                 735     


Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr 
            740                 745                 750         


Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala 
        755                 760                 765             


Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp 
    770                 775                 780                 


Gly Glu Thr Val His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln 
785                 790                 795                 800 


Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys 
                805                 810                 815     


Asp Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys 
            820                 825                 830         


Ile Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val 
        835                 840                 845             


Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro 
    850                 855                 860                 


Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala 
865                 870                 875                 880 


Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr 
                885                 890                 895     


Arg Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr 
            900                 905                 910         


Arg Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn 
        915                 920                 925             


Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys 
    930                 935                 940                 


Arg Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr 
945                 950                 955                 960 


Tyr Asp Arg Asp Cys Ser Trp Glu Glu Asn Lys Leu Asp Ser Ala Ala 
                965                 970                 975     


Ser Lys Leu Asp Asn Ala Arg Gln Lys Phe Glu Lys Glu Lys Asn Lys 
            980                 985                 990         


Leu Lys Lys Leu Asp Val Leu Glu  Glu Lys Tyr Thr Asn  Pro Glu Thr 
        995                 1000                 1005             


Val Val  Val Leu Lys His Asn  Gly Gln Gln Val Ala  Leu Gln Lys 
    1010                 1015                 1020             


Val Arg  Leu Thr Glu Gly Glu  Lys Lys Thr Leu Asn  Leu Asp Trp 
    1025                 1030                 1035             


Gln His  Lys Gly Lys Gly Thr  Ile Gln Ala Glu Ile  Asn Pro Ala 
    1040                 1045                 1050             


Gly Asn  Arg Ile Asp Ile Glu  Glu Thr Thr Tyr Lys  Asn Asn Pro 
    1055                 1060                 1065             


Ile Lys  Thr Ala Ile Tyr Glu  Pro Ser Lys Glu Lys  Ala Met Cys 
    1070                 1075                 1080             


Gly Val  Thr Ser Val Lys Gly  Val Val Glu Thr Val  Ser Glu Arg 
    1085                 1090                 1095             


Val Ser  Lys Glu Asp Ile Thr  Gly Glu Met Tyr Tyr  Glu Thr Leu 
    1100                 1105                 1110             


Thr Gly  Ser Ile Asp Asn Leu  Ala Pro Ser Lys Leu  His Ser Gly 
    1115                 1120                 1125             


Tyr Gly  Phe Ser Tyr Glu Val  Asn Gly Lys Tyr Lys  Asn Asp Trp 
    1130                 1135                 1140             


Asn Ala  Asn Tyr Pro Gly Val  Phe Thr Ala Ala Lys  Ala Gln Tyr 
    1145                 1150                 1155             


Pro Phe  Ala Asp Glu Gly Leu  Lys Ser Thr Gln Asp  Leu Glu Lys 
    1160                 1165                 1170             


Lys Glu  Leu Lys Asp Asn Thr  Ala Lys Phe Leu Pro  Lys Asn Met 
    1175                 1180                 1185             


Tyr Leu  Ser Glu Ala Thr Gly  His Val Phe Asp Ser  Lys Arg Pro 
    1190                 1195                 1200             


Thr Lys  Ser Leu Tyr Trp Asp  Gly Gln Glu Lys Ile  Ile Asp Gly 
    1205                 1210                 1215             


Gly Gln  Lys Trp Tyr Ser Pro  Leu Lys Thr Lys Asp  Gly Val Tyr 
    1220                 1225                 1230             


Thr Phe  Asn Val Glu Thr Ala  Pro Ala Gly Ile Asn  Glu Met Ser 
    1235                 1240                 1245             


Leu Cys  Leu Thr Glu Gln Val  Glu Ile Lys Gly Val  Ala Tyr Asp 
    1250                 1255                 1260             


Asp Phe  Ile Lys Arg Arg Val  Phe Pro Asp Asp Pro  Phe Pro Gly 
    1265                 1270                 1275             


Gly Ser  Gly Val Gly Trp Asn  Trp Val Gly Lys Glu  Glu Leu Leu 
    1280                 1285                 1290             


His Lys  Leu Thr Asp Trp Tyr  Tyr Met Lys Thr Gly  Lys Pro Lys 
    1295                 1300                 1305             


Lys Lys  Arg Lys Val Glu Asn  Leu Tyr Phe Gln Ser  Gly Ser His 
    1310                 1315                 1320             


His His  His His His His His  His His 
    1325                 1330         


<210> 45
<211> 1316
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Met Lys Asn Asn Asp Val Pro Phe Tyr Asn Gly Asn Glu Asp 
            20                  25                  30          


Thr Phe Val Lys Ser Ala Gln Leu Gln Met Pro Gly Lys Tyr Phe Arg 
        35                  40                  45              


Pro Gly Ser Tyr Ser Pro Gln Gly Thr Asp Leu Met Tyr Lys Gly Asp 
    50                  55                  60                  


Ile His Tyr Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro 
65                  70                  75                  80  


Lys Glu Asn Leu Val Gln Gly Asn Asp Ser Ser Glu Pro Tyr Ile Arg 
                85                  90                  95      


Ile Ser Asn Glu Gly Tyr Phe Asn Ser Ser Val Pro Val Gly Asp Arg 
            100                 105                 110         


Met Val Thr Glu Ile Glu Arg Val Thr Glu Pro Ile Ile Ser Asn Lys 
        115                 120                 125             


Tyr Trp Gly Asn Pro Glu Phe Val Leu Gly Asn Ile Lys Glu His Ile 
    130                 135                 140                 


Ile Arg Asn Asp Lys Thr Asn Glu Met Tyr Gly Gln Phe Tyr Trp Ile 
145                 150                 155                 160 


Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val 
                165                 170                 175     


Asp Asn Val Asn Asn Tyr Asn Leu Trp Tyr Val Arg Thr Ser Lys Pro 
            180                 185                 190         


Glu Leu Lys Glu Phe Lys Ala Ser Ser Gly Lys Lys Asp Asp Pro Val 
        195                 200                 205             


Lys Phe Ile Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr 
    210                 215                 220                 


Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ser Glu 
225                 230                 235                 240 


Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile Ile Lys Asn 
                245                 250                 255     


Gly Glu Thr Val His His Gln Gly Asn Tyr Leu Arg Ser Asn Pro Gln 
            260                 265                 270         


Lys Asn Asn Asp Lys Pro Asn Glu Gly Asp Ala Gly Tyr Phe Ser Lys 
        275                 280                 285             


Glu Gly Ile Pro Phe Tyr Pro Gln Glu Cys Gly Arg Tyr Thr Ala Lys 
    290                 295                 300                 


Leu Lys Leu Ile Asp Ala Val Gln Arg Glu Ser Thr Glu Lys Val Val 
305                 310                 315                 320 


Asp Phe Val Val Asp Gly Ser Cys Gly Thr Gln Val Pro Pro Thr Thr 
                325                 330                 335     


Asp Pro Val Asp Gly Glu Phe Asn Tyr Lys Ile Asp Tyr Ser Ala Asp 
            340                 345                 350         


Arg Ile Glu Gly Glu Thr Ala Arg Lys Asp Lys Glu Ile Lys Thr Arg 
        355                 360                 365             


Val Asp Val Ser Arg Ala Ser Phe Lys Glu Glu His Asp Gln Tyr Arg 
    370                 375                 380                 


Ala Lys Leu Asp Glu Glu Phe Lys Lys Tyr Gln Lys Glu Val Asp Ala 
385                 390                 395                 400 


Tyr Ile Ser Glu Arg Asp Ser Ala Gln Asp Ser Leu Asn Tyr Cys Arg 
                405                 410                 415     


Arg Asn Pro Ile Arg Glu Glu Asp Glu Lys Gly Gly Val His Tyr Arg 
            420                 425                 430         


Asp Arg Asp Cys Ser Trp Glu Glu Asn Asn Leu Asp Asn Val Val Ser 
        435                 440                 445             


Lys Leu Glu Lys Ala Lys Gln Asn Arg Glu Lys Leu Ser Lys Lys Leu 
    450                 455                 460                 


Gly Asp Phe Asp Lys Leu Asn Ala Gln Tyr His Asn Pro Glu Val Thr 
465                 470                 475                 480 


Val Ile Leu Lys His Asn Gly Lys Lys Val Glu Ser Lys Thr Val Arg 
                485                 490                 495     


Leu Lys Glu Gly Glu Lys Lys Thr Val Phe Phe Asn Trp Glu His Lys 
            500                 505                 510         


Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala Asp Glu Asp Gly 
        515                 520                 525             


Ser Arg Leu Asp Ile Lys Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys 
    530                 535                 540                 


Thr Ala Ile Tyr Glu Pro Ser Gln Glu Lys Ala Met Cys Gly Ala Thr 
545                 550                 555                 560 


Ser Val Lys Gly Val Val Glu Thr Val Ser Asn Arg Val Ser Val Glu 
                565                 570                 575     


Asp Thr Val Gly Glu Met Tyr His Glu Thr Leu Thr Gly Ser Ile Asp 
            580                 585                 590         


Lys Leu Val Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Thr Tyr Glu 
        595                 600                 605             


Leu Asp Gly Lys Tyr Thr Asn Asn Trp Asp Gln Asn Tyr Gln Gly Val 
    610                 615                 620                 


Phe Thr Val Ala Thr Ala Lys Tyr Pro Phe Ala Asp Glu Gly Leu Lys 
625                 630                 635                 640 


Leu Asn Gln Asp Leu Glu Lys Lys Glu Ile Lys Asp Asn Thr Ser Lys 
                645                 650                 655     


Phe Ile Pro Lys Asn Met Tyr Leu Ser Glu Lys Thr Gly Tyr Val Phe 
            660                 665                 670         


Asp Ser Lys Arg Pro Ile Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys 
        675                 680                 685             


Ile Ile Asp Gly Gly His Lys Trp Tyr Ala Pro Met Lys Thr Lys Asp 
    690                 695                 700                 


Gly Lys Tyr Ser Phe Lys Val Glu Thr Lys Pro Thr Gly Ile Asn Glu 
705                 710                 715                 720 


Met Ser Leu Cys Met Thr Glu Glu Val Glu Ile Lys Gly Val Ala Tyr 
                725                 730                 735     


Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro Gly 
            740                 745                 750         


Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu His 
        755                 760                 765             


Lys Leu Thr Asp Trp Tyr Tyr Met Lys Asn Gly Asn Lys Asn Lys Ile 
    770                 775                 780                 


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
785                 790                 795                 800 


Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu Arg His 
                805                 810                 815     


Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu Ile Ala 
            820                 825                 830         


Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met Glu Phe 
        835                 840                 845             


Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly Ser Arg 
    850                 855                 860                 


Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp Tyr Gly 
865                 870                 875                 880 


Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu Pro Ile 
                885                 890                 895     


Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln Thr Arg 
            900                 905                 910         


Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro Ser Ser 
        915                 920                 925             


Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys Gly Asn 
    930                 935                 940                 


Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys Asn Gly 
945                 950                 955                 960 


Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met Ile Lys 
                965                 970                 975     


Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn Asn Gly 
            980                 985                 990         


Glu Ile Asn Phe Gly Gly Ser Gly  Ser Gly Ser Gly Ser  Gly Ser Ile 
        995                 1000                 1005             


Thr Arg  Thr Thr Asn Pro Arg  Asn Val Val Pro Lys  Ile Tyr Met 
    1010                 1015                 1020             


Ser Ala  Gly Ser Ile Pro Leu  Thr Thr His Ile Thr  Asn Ser Ile 
    1025                 1030                 1035             


Gln Pro  Thr Leu Trp Thr Ile  Gly Ser Ile Asn Gly  Val Ala Pro 
    1040                 1045                 1050             


Leu Ala  Lys Ser Ile Lys Leu  Gly Ile Pro Val Thr  Gly Ser Ala 
    1055                 1060                 1065             


Tyr Thr  Asp Gln Thr Thr Ala  Met Val Arg Lys Lys  Val Ser Val 
    1070                 1075                 1080             


Phe Met  Gly Ser Gly Ser Gly  Ser Gly Ser Ser Gln  Leu Val Lys 
    1085                 1090                 1095             


Ser Glu  Leu Glu Glu Lys Lys  Ser Glu Leu Arg His  Lys Leu Lys 
    1100                 1105                 1110             


Tyr Val  Pro His Glu Tyr Ile  Glu Leu Ile Glu Ile  Ala Arg Asn 
    1115                 1120                 1125             


Ser Thr  Gln Asp Arg Ile Leu  Glu Met Lys Val Met  Glu Phe Phe 
    1130                 1135                 1140             


Met Lys  Val Tyr Gly Tyr Arg  Gly Lys His Leu Gly  Gly Ser Arg 
    1145                 1150                 1155             


Lys Pro  Asp Gly Ala Ile Tyr  Thr Val Gly Ser Pro  Ile Asp Tyr 
    1160                 1165                 1170             


Gly Val  Ile Val Asp Thr Lys  Ala Tyr Ser Gly Gly  Tyr Asn Leu 
    1175                 1180                 1185             


Pro Ile  Gly Gln Ala Asp Glu  Met Gln Arg Tyr Val  Glu Glu Asn 
    1190                 1195                 1200             


Gln Thr  Arg Asn Lys His Ile  Asn Pro Asn Glu Trp  Trp Lys Val 
    1205                 1210                 1215             


Tyr Pro  Ser Ser Val Thr Glu  Phe Lys Phe Leu Phe  Val Ser Gly 
    1220                 1225                 1230             


His Phe  Lys Gly Asn Tyr Lys  Ala Gln Leu Thr Arg  Leu Asn His 
    1235                 1240                 1245             


Ile Thr  Asn Cys Asn Gly Ala  Val Leu Ser Val Glu  Glu Leu Leu 
    1250                 1255                 1260             


Ile Gly  Gly Glu Met Ile Lys  Ala Gly Thr Leu Thr  Leu Glu Glu 
    1265                 1270                 1275             


Val Arg  Arg Lys Phe Asn Asn  Gly Glu Ile Asn Phe  Pro Lys Lys 
    1280                 1285                 1290             


Lys Arg  Lys Val Glu Asn Leu  Tyr Phe Gln Ser Gly  Ser His His 
    1295                 1300                 1305             


His His  His His His His His  His 
    1310                 1315     


<210> 46
<211> 1316
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Gln Leu Val Lys Ser Glu Leu Glu Glu Lys Lys Ser Glu Leu 
            20                  25                  30          


Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile Glu Leu Ile Glu 
        35                  40                  45              


Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu Met Lys Val Met 
    50                  55                  60                  


Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys His Leu Gly Gly 
65                  70                  75                  80  


Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly Ser Pro Ile Asp 
                85                  90                  95      


Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly Gly Tyr Asn Leu 
            100                 105                 110         


Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val Glu Glu Asn Gln 
        115                 120                 125             


Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp Lys Val Tyr Pro 
    130                 135                 140                 


Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser Gly His Phe Lys 
145                 150                 155                 160 


Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His Ile Thr Asn Cys 
                165                 170                 175     


Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile Gly Gly Glu Met 
            180                 185                 190         


Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg Arg Lys Phe Asn 
        195                 200                 205             


Asn Gly Glu Ile Asn Phe Gly Gly Ser Gly Ser Gly Ser Gly Ser Gly 
    210                 215                 220                 


Ser Ile Thr Arg Thr Thr Asn Pro Arg Asn Val Val Pro Lys Ile Tyr 
225                 230                 235                 240 


Met Ser Ala Gly Ser Ile Pro Leu Thr Thr His Ile Thr Asn Ser Ile 
                245                 250                 255     


Gln Pro Thr Leu Trp Thr Ile Gly Ser Ile Asn Gly Val Ala Pro Leu 
            260                 265                 270         


Ala Lys Ser Ile Lys Leu Gly Ile Pro Val Thr Gly Ser Ala Tyr Thr 
        275                 280                 285             


Asp Gln Thr Thr Ala Met Val Arg Lys Lys Val Ser Val Phe Met Gly 
    290                 295                 300                 


Ser Gly Ser Gly Ser Gly Ser Ser Gln Leu Val Lys Ser Glu Leu Glu 
305                 310                 315                 320 


Glu Lys Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu 
                325                 330                 335     


Tyr Ile Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile 
            340                 345                 350         


Leu Glu Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg 
        355                 360                 365             


Gly Lys His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr 
    370                 375                 380                 


Val Gly Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr 
385                 390                 395                 400 


Ser Gly Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg 
                405                 410                 415     


Tyr Val Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu 
            420                 425                 430         


Trp Trp Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe 
        435                 440                 445             


Val Ser Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu 
    450                 455                 460                 


Asn His Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu 
465                 470                 475                 480 


Leu Ile Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu 
                485                 490                 495     


Val Arg Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ser Gly Ser Glu 
            500                 505                 510         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Met Lys Asn Asn 
        515                 520                 525             


Asp Val Pro Phe Tyr Asn Gly Asn Glu Asp Thr Phe Val Lys Ser Ala 
    530                 535                 540                 


Gln Leu Gln Met Pro Gly Lys Tyr Phe Arg Pro Gly Ser Tyr Ser Pro 
545                 550                 555                 560 


Gln Gly Thr Asp Leu Met Tyr Lys Gly Asp Ile His Tyr Pro Ala Val 
                565                 570                 575     


Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu Val Gln 
            580                 585                 590         


Gly Asn Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ser Asn Glu Gly Tyr 
        595                 600                 605             


Phe Asn Ser Ser Val Pro Val Gly Asp Arg Met Val Thr Glu Ile Glu 
    610                 615                 620                 


Arg Val Thr Glu Pro Ile Ile Ser Asn Lys Tyr Trp Gly Asn Pro Glu 
625                 630                 635                 640 


Phe Val Leu Gly Asn Ile Lys Glu His Ile Ile Arg Asn Asp Lys Thr 
                645                 650                 655     


Asn Glu Met Tyr Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu 
            660                 665                 670         


Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Asp Asn Val Asn Asn Tyr 
        675                 680                 685             


Asn Leu Trp Tyr Val Arg Thr Ser Lys Pro Glu Leu Lys Glu Phe Lys 
    690                 695                 700                 


Ala Ser Ser Gly Lys Lys Asp Asp Pro Val Lys Phe Ile Phe Asn Gly 
705                 710                 715                 720 


Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn 
                725                 730                 735     


Gly Thr Thr Val Asn Pro Tyr Gln Ser Glu Ala Gly Glu Arg Asn Arg 
            740                 745                 750         


Val Lys Trp Met Leu Asp Ile Ile Lys Asn Gly Glu Thr Val His His 
        755                 760                 765             


Gln Gly Asn Tyr Leu Arg Ser Asn Pro Gln Lys Asn Asn Asp Lys Pro 
    770                 775                 780                 


Asn Glu Gly Asp Ala Gly Tyr Phe Ser Lys Glu Gly Ile Pro Phe Tyr 
785                 790                 795                 800 


Pro Gln Glu Cys Gly Arg Tyr Thr Ala Lys Leu Lys Leu Ile Asp Ala 
                805                 810                 815     


Val Gln Arg Glu Ser Thr Glu Lys Val Val Asp Phe Val Val Asp Gly 
            820                 825                 830         


Ser Cys Gly Thr Gln Val Pro Pro Thr Thr Asp Pro Val Asp Gly Glu 
        835                 840                 845             


Phe Asn Tyr Lys Ile Asp Tyr Ser Ala Asp Arg Ile Glu Gly Glu Thr 
    850                 855                 860                 


Ala Arg Lys Asp Lys Glu Ile Lys Thr Arg Val Asp Val Ser Arg Ala 
865                 870                 875                 880 


Ser Phe Lys Glu Glu His Asp Gln Tyr Arg Ala Lys Leu Asp Glu Glu 
                885                 890                 895     


Phe Lys Lys Tyr Gln Lys Glu Val Asp Ala Tyr Ile Ser Glu Arg Asp 
            900                 905                 910         


Ser Ala Gln Asp Ser Leu Asn Tyr Cys Arg Arg Asn Pro Ile Arg Glu 
        915                 920                 925             


Glu Asp Glu Lys Gly Gly Val His Tyr Arg Asp Arg Asp Cys Ser Trp 
    930                 935                 940                 


Glu Glu Asn Asn Leu Asp Asn Val Val Ser Lys Leu Glu Lys Ala Lys 
945                 950                 955                 960 


Gln Asn Arg Glu Lys Leu Ser Lys Lys Leu Gly Asp Phe Asp Lys Leu 
                965                 970                 975     


Asn Ala Gln Tyr His Asn Pro Glu Val Thr Val Ile Leu Lys His Asn 
            980                 985                 990         


Gly Lys Lys Val Glu Ser Lys Thr  Val Arg Leu Lys Glu  Gly Glu Lys 
        995                 1000                 1005             


Lys Thr  Val Phe Phe Asn Trp  Glu His Lys Gly Lys  Gly Thr Ile 
    1010                 1015                 1020             


Gln Ala  Glu Ile Asn Pro Ala  Asp Glu Asp Gly Ser  Arg Leu Asp 
    1025                 1030                 1035             


Ile Lys  Glu Thr Thr Tyr Lys  Asn Asn Pro Ile Lys  Thr Ala Ile 
    1040                 1045                 1050             


Tyr Glu  Pro Ser Gln Glu Lys  Ala Met Cys Gly Ala  Thr Ser Val 
    1055                 1060                 1065             


Lys Gly  Val Val Glu Thr Val  Ser Asn Arg Val Ser  Val Glu Asp 
    1070                 1075                 1080             


Thr Val  Gly Glu Met Tyr His  Glu Thr Leu Thr Gly  Ser Ile Asp 
    1085                 1090                 1095             


Lys Leu  Val Pro Ser Lys Leu  His Ser Gly Tyr Gly  Phe Thr Tyr 
    1100                 1105                 1110             


Glu Leu  Asp Gly Lys Tyr Thr  Asn Asn Trp Asp Gln  Asn Tyr Gln 
    1115                 1120                 1125             


Gly Val  Phe Thr Val Ala Thr  Ala Lys Tyr Pro Phe  Ala Asp Glu 
    1130                 1135                 1140             


Gly Leu  Lys Leu Asn Gln Asp  Leu Glu Lys Lys Glu  Ile Lys Asp 
    1145                 1150                 1155             


Asn Thr  Ser Lys Phe Ile Pro  Lys Asn Met Tyr Leu  Ser Glu Lys 
    1160                 1165                 1170             


Thr Gly  Tyr Val Phe Asp Ser  Lys Arg Pro Ile Lys  Ser Leu Tyr 
    1175                 1180                 1185             


Trp Asp  Gly Gln Glu Lys Ile  Ile Asp Gly Gly His  Lys Trp Tyr 
    1190                 1195                 1200             


Ala Pro  Met Lys Thr Lys Asp  Gly Lys Tyr Ser Phe  Lys Val Glu 
    1205                 1210                 1215             


Thr Lys  Pro Thr Gly Ile Asn  Glu Met Ser Leu Cys  Met Thr Glu 
    1220                 1225                 1230             


Glu Val  Glu Ile Lys Gly Val  Ala Tyr Asp Asp Phe  Ile Lys Arg 
    1235                 1240                 1245             


Arg Val  Phe Pro Asp Asp Pro  Phe Pro Gly Gly Ser  Gly Val Gly 
    1250                 1255                 1260             


Trp Asn  Trp Val Gly Lys Glu  Glu Leu Leu His Lys  Leu Thr Asp 
    1265                 1270                 1275             


Trp Tyr  Tyr Met Lys Asn Gly  Asn Lys Asn Lys Ile  Pro Lys Lys 
    1280                 1285                 1290             


Lys Arg  Lys Val Glu Asn Leu  Tyr Phe Gln Ser Gly  Ser His His 
    1295                 1300                 1305             


His His  His His His His His  His 
    1310                 1315     


<210> 47
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Pro Lys Lys Lys Arg Lys Val 
1               5           


<210> 48
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210> 49
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp Tyr 
1               5                   10                  15      


Lys Asp Asp Asp Asp Lys 
            20          


<210> 50
<211> 203
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 50
tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca cggggatttc       60

caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat caacgggact      120

ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg cgtgtacggt      180

gggaggtcta tataagcaga gct                                              203


<210> 51
<211> 318
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 51
tgtacaaaaa agcaggcttt aaaggaacca attcagtcga ctggatccgg taccaaggtc       60

gggcaggaag agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct      120

gttagagaga taattagaat taatttgact gtaaacacaa agatattagt acaaaatacg      180

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg      240

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg      300

tggaaaggac gaaacacc                                                    318


<210> 52
<211> 4
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 52
aaag                                                                     4


<210> 53
<211> 1644
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 53
gacgcattgg acgattttga tctggatatg ctgggaagtg acgccctcga tgattttgac       60

cttgacatgc ttggttcgga tgcccttgat gactttgacc tcgacatgct cggcagtgac      120

gcccttgatg atttcgacct ggacatgctg attaactcta gaagttccgg atctggtagc      180

cagtacctgc ccgacaccga cgaccggcac cggatcgagg aaaagcggaa gcggacctac      240

gagacattca agagcatcat gaagaagtcc cccttcagcg gccccaccga ccctagacct      300

ccacctagaa gaatcgccgt gcccagcaga tccagcgcca gcgtgccaaa acctgccccc      360

cagccttacc ccttcaccag cagcctgagc accatcaact acgacgagtt ccctaccatg      420

gtgttcccca gcggccagat ctctcaggcc tctgctctgg ctccagcccc tcctcaggtg      480

ctgcctcagg ctcctgctcc tgcaccagct ccagccatgg tgtctgcact ggctcaggca      540

ccagcacccg tgcctgtgct ggctcctgga cctccacagg ctgtggctcc accagcccct      600

aaacctacac aggccggcga gggcacactg tctgaagctc tgctgcagct gcagttcgac      660

gacgaggatc tgggagccct gctgggaaac agcaccgatc ctgccgtgtt caccgacctg      720

gccagcgtgg acaacagcga gttccagcag ctgctgaacc agggcatccc tgtggcccct      780

cacaccaccg agcccatgct gatggaatac cccgaggcca tcacccggct cgtgacaggc      840

gctcagaggc ctcctgatcc agctcctgcc cctctgggag caccaggcct gcctaatgga      900

ctgctgtctg gcgacgagga cttcagctct atcgccgata tggatttctc agccttgctg      960

ggctctggca gcggcagccg ggattccagg gaagggatgt ttttgccgaa gcctgaggcc     1020

ggctccgcta ttagtgacgt gtttgagggc cgcgaggtgt gccagccaaa acgaatccgg     1080

ccatttcatc ctccaggaag tccatgggcc aaccgcccac tccccgccag cctcgcacca     1140

acaccaaccg gtccagtaca tgagccagtc gggtcactga ccccggcacc agtccctcag     1200

ccactagatc cagcgcccgc agtgactccc gaggccagtc acctgttgga agatcccgat     1260

gaagagacga gccaggctgt caaagccctt cgggagatgg ccgatactgt gattccccag     1320

aaggaagagg ctgcaatctg tggccaaatg gacctttccc atccgccccc aaggggccat     1380

ctggatgagc tgacaaccac acttgagtcc atgaccgagg atctgaacct ggactcaccc     1440

ctgaccccgg aattgaacga gattctggat accttcctga acgacgagtg cctcttgcat     1500

gccatgcata tcagcacagg actgtccatc ttcgacacat ctctgttttc cggaggatct     1560

agcggaggct cctctggctc tgagacacct ggcacaagcg agagcgcaac acctgaaagc     1620

agcgggggca gcagcggggg gtca                                            1644


<210> 54
<211> 1371
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Leu Lys Arg Gly Leu Leu Val Leu Cys Thr Ser Thr Ala Leu Ile 
        35                  40                  45              


Tyr Pro Ser Ile Val Asn Ala Lys Asn Asn Asp Val Pro Phe Tyr Asp 
    50                  55                  60                  


Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly 
65                  70                  75                  80  


Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr 
                85                  90                  95      


Arg Ala Asp Ile His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp 
            100                 105                 110         


Gly Asn Pro Lys Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu Pro 
        115                 120                 125             


Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala 
    130                 135                 140                 


Gly Asp Arg Met Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val Ile 
145                 150                 155                 160 


Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile Asp 
                165                 170                 175     


Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe 
            180                 185                 190         


Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala 
        195                 200                 205             


Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr 
    210                 215                 220                 


Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp 
225                 230                 235                 240 


Val Pro Val Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn 
                245                 250                 255     


Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr 
            260                 265                 270         


Gln Ala Ala Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile 
        275                 280                 285             


Thr Lys Asp Gly Glu Thr Val His His Gln Glu Asn Tyr Leu Arg Ser 
    290                 295                 300                 


Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys 
305                 310                 315                 320 


Phe Val Lys Asp Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr 
                325                 330                 335     


Thr Ala Lys Ile Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn Glu 
            340                 345                 350         


Lys Asn Val Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val Thr 
        355                 360                 365             


Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp 
    370                 375                 380                 


Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn 
385                 390                 395                 400 


Ile Lys Thr Arg Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu Arg 
                405                 410                 415     


Asp Gln Tyr Arg Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln Gln 
            420                 425                 430         


Glu Val Asn Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu 
        435                 440                 445             


Ser Tyr Cys Arg Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly Lys 
    450                 455                 460                 


Asp His Tyr Tyr Asp Arg Asp Cys Ser Trp Glu Glu Asn Lys Leu Asp 
465                 470                 475                 480 


Ser Ala Ala Ser Lys Leu Asp Asn Ala Arg Gln Lys Phe Glu Lys Glu 
                485                 490                 495     


Lys Asn Lys Leu Lys Lys Leu Asp Val Leu Glu Glu Lys Tyr Thr Asn 
            500                 505                 510         


Pro Glu Thr Val Val Val Leu Lys His Asn Gly Gln Gln Val Ala Leu 
        515                 520                 525             


Gln Lys Val Arg Leu Thr Glu Gly Glu Lys Lys Thr Leu Asn Leu Asp 
    530                 535                 540                 


Trp Gln His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala 
545                 550                 555                 560 


Gly Asn Arg Ile Asp Ile Glu Glu Thr Thr Tyr Lys Asn Asn Pro Ile 
                565                 570                 575     


Lys Thr Ala Ile Tyr Glu Pro Ser Lys Glu Lys Ala Met Cys Gly Val 
            580                 585                 590         


Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Glu Arg Val Ser Lys 
        595                 600                 605             


Glu Asp Ile Thr Gly Glu Met Tyr Tyr Glu Thr Leu Thr Gly Ser Ile 
    610                 615                 620                 


Asp Asn Leu Ala Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Ser Tyr 
625                 630                 635                 640 


Glu Val Asn Gly Lys Tyr Lys Asn Asp Trp Asn Ala Asn Tyr Pro Gly 
                645                 650                 655     


Val Phe Thr Ala Ala Lys Ala Gln Tyr Pro Phe Ala Asp Glu Gly Leu 
            660                 665                 670         


Lys Ser Thr Gln Asp Leu Glu Lys Lys Glu Leu Lys Asp Asn Thr Ala 
        675                 680                 685             


Lys Phe Leu Pro Lys Asn Met Tyr Leu Ser Glu Ala Thr Gly His Val 
    690                 695                 700                 


Phe Asp Ser Lys Arg Pro Thr Lys Ser Leu Tyr Trp Asp Gly Gln Glu 
705                 710                 715                 720 


Lys Ile Ile Asp Gly Gly Gln Lys Trp Tyr Ser Pro Leu Lys Thr Lys 
                725                 730                 735     


Asp Gly Val Tyr Thr Phe Asn Val Glu Thr Ala Pro Ala Gly Ile Asn 
            740                 745                 750         


Glu Met Ser Leu Cys Leu Thr Glu Gln Val Glu Ile Lys Gly Val Ala 
        755                 760                 765             


Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro 
    770                 775                 780                 


Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu 
785                 790                 795                 800 


His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Thr Gly Lys Lys Arg Pro 
                805                 810                 815     


Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Gly Arg Leu 
            820                 825                 830         


Asp Ala Leu Ile Ser Thr Ser Leu Tyr Lys Lys Ala Gly Tyr Lys Glu 
        835                 840                 845             


Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
    850                 855                 860                 


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
865                 870                 875                 880 


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
                885                 890                 895     


Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg Ser Ser Gly 
            900                 905                 910         


Ser Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu 
        915                 920                 925             


Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys 
    930                 935                 940                 


Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile 
945                 950                 955                 960 


Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln 
                965                 970                 975     


Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe 
            980                 985                 990         


Pro Thr Met Val Phe Pro Ser Gly  Gln Ile Ser Gln Ala  Ser Ala Leu 
        995                 1000                 1005             


Ala Pro  Ala Pro Pro Gln Val  Leu Pro Gln Ala Pro  Ala Pro Ala 
    1010                 1015                 1020             


Pro Ala  Pro Ala Met Val Ser  Ala Leu Ala Gln Ala  Pro Ala Pro 
    1025                 1030                 1035             


Val Pro  Val Leu Ala Pro Gly  Pro Pro Gln Ala Val  Ala Pro Pro 
    1040                 1045                 1050             


Ala Pro  Lys Pro Thr Gln Ala  Gly Glu Gly Thr Leu  Ser Glu Ala 
    1055                 1060                 1065             


Leu Leu  Gln Leu Gln Phe Asp  Asp Glu Asp Leu Gly  Ala Leu Leu 
    1070                 1075                 1080             


Gly Asn  Ser Thr Asp Pro Ala  Val Phe Thr Asp Leu  Ala Ser Val 
    1085                 1090                 1095             


Asp Asn  Ser Glu Phe Gln Gln  Leu Leu Asn Gln Gly  Ile Pro Val 
    1100                 1105                 1110             


Ala Pro  His Thr Thr Glu Pro  Met Leu Met Glu Tyr  Pro Glu Ala 
    1115                 1120                 1125             


Ile Thr  Arg Leu Val Thr Gly  Ala Gln Arg Pro Pro  Asp Pro Ala 
    1130                 1135                 1140             


Pro Ala  Pro Leu Gly Ala Pro  Gly Leu Pro Asn Gly  Leu Leu Ser 
    1145                 1150                 1155             


Gly Asp  Glu Asp Phe Ser Ser  Ile Ala Asp Met Asp  Phe Ser Ala 
    1160                 1165                 1170             


Leu Leu  Gly Ser Gly Ser Gly  Ser Arg Asp Ser Arg  Glu Gly Met 
    1175                 1180                 1185             


Phe Leu  Pro Lys Pro Glu Ala  Gly Ser Ala Ile Ser  Asp Val Phe 
    1190                 1195                 1200             


Glu Gly  Arg Glu Val Cys Gln  Pro Lys Arg Ile Arg  Pro Phe His 
    1205                 1210                 1215             


Pro Pro  Gly Ser Pro Trp Ala  Asn Arg Pro Leu Pro  Ala Ser Leu 
    1220                 1225                 1230             


Ala Pro  Thr Pro Thr Gly Pro  Val His Glu Pro Val  Gly Ser Leu 
    1235                 1240                 1245             


Thr Pro  Ala Pro Val Pro Gln  Pro Leu Asp Pro Ala  Pro Ala Val 
    1250                 1255                 1260             


Thr Pro  Glu Ala Ser His Leu  Leu Glu Asp Pro Asp  Glu Glu Thr 
    1265                 1270                 1275             


Ser Gln  Ala Val Lys Ala Leu  Arg Glu Met Ala Asp  Thr Val Ile 
    1280                 1285                 1290             


Pro Gln  Lys Glu Glu Ala Ala  Ile Cys Gly Gln Met  Asp Leu Ser 
    1295                 1300                 1305             


His Pro  Pro Pro Arg Gly His  Leu Asp Glu Leu Thr  Thr Thr Leu 
    1310                 1315                 1320             


Glu Ser  Met Thr Glu Asp Leu  Asn Leu Asp Ser Pro  Leu Thr Pro 
    1325                 1330                 1335             


Glu Leu  Asn Glu Ile Leu Asp  Thr Phe Leu Asn Asp  Glu Cys Leu 
    1340                 1345                 1350             


Leu His  Ala Met His Ile Ser  Thr Gly Leu Ser Ile  Phe Asp Thr 
    1355                 1360                 1365             


Ser Leu  Phe 
    1370     


<210> 55
<211> 1348
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn Asp Thr Phe Leu 
        35                  40                  45              


Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe Arg Pro Gly Ser 
    50                  55                  60                  


Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp Ile His Phe Pro 
65                  70                  75                  80  


Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu 
                85                  90                  95      


Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ala Asn Glu 
            100                 105                 110         


Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg Met Val Thr Glu 
        115                 120                 125             


Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys Tyr Trp Gly Asn 
    130                 135                 140                 


Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser Ile Asn Thr Tyr 
145                 150                 155                 160 


Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala 
                165                 170                 175     


Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Glu Gly Ile Asn 
            180                 185                 190         


Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro Glu Leu Lys Asp 
        195                 200                 205             


Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val Lys Phe Thr Phe 
    210                 215                 220                 


Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp 
225                 230                 235                 240 


Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala Ala Gly Glu Arg 
                245                 250                 255     


Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp Gly Glu Thr Val 
            260                 265                 270         


His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln Lys Asp Asn Glu 
        275                 280                 285             


Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys Asp Asp Val Lys 
    290                 295                 300                 


Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys Ile Lys Val Leu 
305                 310                 315                 320 


Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val Asp Phe Thr Ile 
                325                 330                 335     


Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro Asp Pro Gly Asp 
            340                 345                 350         


Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala Asp Arg Ile Glu 
        355                 360                 365             


Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr Arg Val Asp Val 
    370                 375                 380                 


Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr Arg Val Lys Val 
385                 390                 395                 400 


Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn Ser Ser Glu Ser 
                405                 410                 415     


Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys Arg Arg Asn Pro 
            420                 425                 430         


Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr Tyr Asp Arg Asp 
        435                 440                 445             


Cys Ser Trp Glu Glu Asn Lys Leu Asp Ser Ala Ala Ser Lys Leu Asp 
    450                 455                 460                 


Asn Ala Arg Gln Lys Phe Glu Lys Glu Lys Asn Lys Leu Lys Lys Leu 
465                 470                 475                 480 


Asp Val Leu Glu Glu Lys Tyr Thr Asn Pro Glu Thr Val Val Val Leu 
                485                 490                 495     


Lys His Asn Gly Gln Gln Val Ala Leu Gln Lys Val Arg Leu Thr Glu 
            500                 505                 510         


Gly Glu Lys Lys Thr Leu Asn Leu Asp Trp Gln His Lys Gly Lys Gly 
        515                 520                 525             


Thr Ile Gln Ala Glu Ile Asn Pro Ala Gly Asn Arg Ile Asp Ile Glu 
    530                 535                 540                 


Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro 
545                 550                 555                 560 


Ser Lys Glu Lys Ala Met Cys Gly Val Thr Ser Val Lys Gly Val Val 
                565                 570                 575     


Glu Thr Val Ser Glu Arg Val Ser Lys Glu Asp Ile Thr Gly Glu Met 
            580                 585                 590         


Tyr Tyr Glu Thr Leu Thr Gly Ser Ile Asp Asn Leu Ala Pro Ser Lys 
        595                 600                 605             


Leu His Ser Gly Tyr Gly Phe Ser Tyr Glu Val Asn Gly Lys Tyr Lys 
    610                 615                 620                 


Asn Asp Trp Asn Ala Asn Tyr Pro Gly Val Phe Thr Ala Ala Lys Ala 
625                 630                 635                 640 


Gln Tyr Pro Phe Ala Asp Glu Gly Leu Lys Ser Thr Gln Asp Leu Glu 
                645                 650                 655     


Lys Lys Glu Leu Lys Asp Asn Thr Ala Lys Phe Leu Pro Lys Asn Met 
            660                 665                 670         


Tyr Leu Ser Glu Ala Thr Gly His Val Phe Asp Ser Lys Arg Pro Thr 
        675                 680                 685             


Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp Gly Gly Gln 
    690                 695                 700                 


Lys Trp Tyr Ser Pro Leu Lys Thr Lys Asp Gly Val Tyr Thr Phe Asn 
705                 710                 715                 720 


Val Glu Thr Ala Pro Ala Gly Ile Asn Glu Met Ser Leu Cys Leu Thr 
                725                 730                 735     


Glu Gln Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg 
            740                 745                 750         


Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly Val Gly Trp 
        755                 760                 765             


Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr Asp Trp Tyr 
    770                 775                 780                 


Tyr Met Lys Thr Gly Lys Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly 
785                 790                 795                 800 


Gln Ala Lys Lys Lys Lys Gly Arg Leu Asp Ala Leu Ile Ser Thr Ser 
                805                 810                 815     


Leu Tyr Lys Lys Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala 
            820                 825                 830         


Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu 
        835                 840                 845             


Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe 
    850                 855                 860                 


Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp 
865                 870                 875                 880 


Met Leu Ile Asn Ser Arg Ser Ser Gly Ser Gly Ser Gln Tyr Leu Pro 
                885                 890                 895     


Asp Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr 
            900                 905                 910         


Glu Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr 
        915                 920                 925             


Asp Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser 
    930                 935                 940                 


Ala Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser 
945                 950                 955                 960 


Leu Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser 
                965                 970                 975     


Gly Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val 
            980                 985                 990         


Leu Pro Gln Ala Pro Ala Pro Ala  Pro Ala Pro Ala Met  Val Ser Ala 
        995                 1000                 1005             


Leu Ala  Gln Ala Pro Ala Pro  Val Pro Val Leu Ala  Pro Gly Pro 
    1010                 1015                 1020             


Pro Gln  Ala Val Ala Pro Pro  Ala Pro Lys Pro Thr  Gln Ala Gly 
    1025                 1030                 1035             


Glu Gly  Thr Leu Ser Glu Ala  Leu Leu Gln Leu Gln  Phe Asp Asp 
    1040                 1045                 1050             


Glu Asp  Leu Gly Ala Leu Leu  Gly Asn Ser Thr Asp  Pro Ala Val 
    1055                 1060                 1065             


Phe Thr  Asp Leu Ala Ser Val  Asp Asn Ser Glu Phe  Gln Gln Leu 
    1070                 1075                 1080             


Leu Asn  Gln Gly Ile Pro Val  Ala Pro His Thr Thr  Glu Pro Met 
    1085                 1090                 1095             


Leu Met  Glu Tyr Pro Glu Ala  Ile Thr Arg Leu Val  Thr Gly Ala 
    1100                 1105                 1110             


Gln Arg  Pro Pro Asp Pro Ala  Pro Ala Pro Leu Gly  Ala Pro Gly 
    1115                 1120                 1125             


Leu Pro  Asn Gly Leu Leu Ser  Gly Asp Glu Asp Phe  Ser Ser Ile 
    1130                 1135                 1140             


Ala Asp  Met Asp Phe Ser Ala  Leu Leu Gly Ser Gly  Ser Gly Ser 
    1145                 1150                 1155             


Arg Asp  Ser Arg Glu Gly Met  Phe Leu Pro Lys Pro  Glu Ala Gly 
    1160                 1165                 1170             


Ser Ala  Ile Ser Asp Val Phe  Glu Gly Arg Glu Val  Cys Gln Pro 
    1175                 1180                 1185             


Lys Arg  Ile Arg Pro Phe His  Pro Pro Gly Ser Pro  Trp Ala Asn 
    1190                 1195                 1200             


Arg Pro  Leu Pro Ala Ser Leu  Ala Pro Thr Pro Thr  Gly Pro Val 
    1205                 1210                 1215             


His Glu  Pro Val Gly Ser Leu  Thr Pro Ala Pro Val  Pro Gln Pro 
    1220                 1225                 1230             


Leu Asp  Pro Ala Pro Ala Val  Thr Pro Glu Ala Ser  His Leu Leu 
    1235                 1240                 1245             


Glu Asp  Pro Asp Glu Glu Thr  Ser Gln Ala Val Lys  Ala Leu Arg 
    1250                 1255                 1260             


Glu Met  Ala Asp Thr Val Ile  Pro Gln Lys Glu Glu  Ala Ala Ile 
    1265                 1270                 1275             


Cys Gly  Gln Met Asp Leu Ser  His Pro Pro Pro Arg  Gly His Leu 
    1280                 1285                 1290             


Asp Glu  Leu Thr Thr Thr Leu  Glu Ser Met Thr Glu  Asp Leu Asn 
    1295                 1300                 1305             


Leu Asp  Ser Pro Leu Thr Pro  Glu Leu Asn Glu Ile  Leu Asp Thr 
    1310                 1315                 1320             


Phe Leu  Asn Asp Glu Cys Leu  Leu His Ala Met His  Ile Ser Thr 
    1325                 1330                 1335             


Gly Leu  Ser Ile Phe Asp Thr  Ser Leu Phe 
    1340                 1345             


<210> 56
<211> 1378
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Phe Lys Lys Gly Ile Phe Val Leu Phe Thr Ser Val Leu Leu Ser 
        35                  40                  45              


Ala Pro Asn Ser Ala Asp Ala Lys Asn Asn Asp Val Pro Phe Tyr Asn 
    50                  55                  60                  


Gly Asn Glu Asp Thr Phe Val Lys Ser Ala Gln Leu Gln Met Pro Gly 
65                  70                  75                  80  


Lys Tyr Phe Arg Pro Gly Ser Tyr Ser Pro Gln Gly Thr Asp Leu Met 
                85                  90                  95      


Tyr Lys Gly Asp Ile His Tyr Pro Ala Val Tyr Asn Gly Ser Phe Asn 
            100                 105                 110         


Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Gly Asn Asp Ser Ser Glu 
        115                 120                 125             


Pro Tyr Ile Arg Ile Ser Asn Glu Gly Tyr Phe Asn Ser Ser Val Pro 
    130                 135                 140                 


Val Gly Asp Arg Met Val Thr Glu Ile Glu Arg Val Thr Glu Pro Ile 
145                 150                 155                 160 


Ile Ser Asn Lys Tyr Trp Gly Asn Pro Glu Phe Val Leu Gly Asn Ile 
                165                 170                 175     


Lys Glu His Ile Ile Arg Asn Asp Lys Thr Asn Glu Met Tyr Gly Gln 
            180                 185                 190         


Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly 
        195                 200                 205             


Ala Gly Ala Val Asp Asn Val Asn Asn Tyr Asn Leu Trp Tyr Val Arg 
    210                 215                 220                 


Thr Ser Lys Pro Glu Leu Lys Glu Phe Lys Ala Ser Ser Gly Lys Lys 
225                 230                 235                 240 


Asp Asp Pro Val Lys Phe Ile Phe Asn Gly Phe Glu Tyr Val Ser Lys 
                245                 250                 255     


Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro 
            260                 265                 270         


Tyr Gln Ser Glu Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp 
        275                 280                 285             


Ile Ile Lys Asn Gly Glu Thr Val His His Gln Gly Asn Tyr Leu Arg 
    290                 295                 300                 


Ser Asn Pro Gln Lys Asn Asn Asp Lys Pro Asn Glu Gly Asp Ala Gly 
305                 310                 315                 320 


Tyr Phe Ser Lys Glu Gly Ile Pro Phe Tyr Pro Gln Glu Cys Gly Arg 
                325                 330                 335     


Tyr Thr Ala Lys Leu Lys Leu Ile Asp Ala Val Gln Arg Glu Ser Thr 
            340                 345                 350         


Glu Lys Val Val Asp Phe Val Val Asp Gly Ser Cys Gly Thr Gln Val 
        355                 360                 365             


Pro Pro Thr Thr Asp Pro Val Asp Gly Glu Phe Asn Tyr Lys Ile Asp 
    370                 375                 380                 


Tyr Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Lys Asp Lys Glu 
385                 390                 395                 400 


Ile Lys Thr Arg Val Asp Val Ser Arg Ala Ser Phe Lys Glu Glu His 
                405                 410                 415     


Asp Gln Tyr Arg Ala Lys Leu Asp Glu Glu Phe Lys Lys Tyr Gln Lys 
            420                 425                 430         


Glu Val Asp Ala Tyr Ile Ser Glu Arg Asp Ser Ala Gln Asp Ser Leu 
        435                 440                 445             


Asn Tyr Cys Arg Arg Asn Pro Ile Arg Glu Glu Asp Glu Lys Gly Gly 
    450                 455                 460                 


Val His Tyr Arg Asp Arg Asp Cys Ser Trp Glu Glu Asn Asn Leu Asp 
465                 470                 475                 480 


Asn Val Val Ser Lys Leu Glu Lys Ala Lys Gln Asn Arg Glu Lys Leu 
                485                 490                 495     


Ser Lys Lys Leu Gly Asp Phe Asp Lys Leu Asn Ala Gln Tyr His Asn 
            500                 505                 510         


Pro Glu Val Thr Val Ile Leu Lys His Asn Gly Lys Lys Val Glu Ser 
        515                 520                 525             


Lys Thr Val Arg Leu Lys Glu Gly Glu Lys Lys Thr Val Phe Phe Asn 
    530                 535                 540                 


Trp Glu His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala 
545                 550                 555                 560 


Asp Glu Asp Gly Ser Arg Leu Asp Ile Lys Glu Thr Thr Tyr Lys Asn 
                565                 570                 575     


Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro Ser Gln Glu Lys Ala Met 
            580                 585                 590         


Cys Gly Ala Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Asn Arg 
        595                 600                 605             


Val Ser Val Glu Asp Thr Val Gly Glu Met Tyr His Glu Thr Leu Thr 
    610                 615                 620                 


Gly Ser Ile Asp Lys Leu Val Pro Ser Lys Leu His Ser Gly Tyr Gly 
625                 630                 635                 640 


Phe Thr Tyr Glu Leu Asp Gly Lys Tyr Thr Asn Asn Trp Asp Gln Asn 
                645                 650                 655     


Tyr Gln Gly Val Phe Thr Val Ala Thr Ala Lys Tyr Pro Phe Ala Asp 
            660                 665                 670         


Glu Gly Leu Lys Leu Asn Gln Asp Leu Glu Lys Lys Glu Ile Lys Asp 
        675                 680                 685             


Asn Thr Ser Lys Phe Ile Pro Lys Asn Met Tyr Leu Ser Glu Lys Thr 
    690                 695                 700                 


Gly Tyr Val Phe Asp Ser Lys Arg Pro Ile Lys Ser Leu Tyr Trp Asp 
705                 710                 715                 720 


Gly Gln Glu Lys Ile Ile Asp Gly Gly His Lys Trp Tyr Ala Pro Met 
                725                 730                 735     


Lys Thr Lys Asp Gly Lys Tyr Ser Phe Lys Val Glu Thr Lys Pro Thr 
            740                 745                 750         


Gly Ile Asn Glu Met Ser Leu Cys Met Thr Glu Glu Val Glu Ile Lys 
        755                 760                 765             


Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp 
    770                 775                 780                 


Pro Phe Pro Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu 
785                 790                 795                 800 


Glu Leu Leu His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Asn Gly Asn 
                805                 810                 815     


Lys Asn Lys Ile Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala 
            820                 825                 830         


Lys Lys Lys Lys Gly Arg Leu Asp Ala Leu Ile Ser Thr Ser Leu Tyr 
        835                 840                 845             


Lys Lys Ala Gly Tyr Lys Glu Ala Ser Gly Ser Gly Arg Ala Asp Ala 
    850                 855                 860                 


Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp 
865                 870                 875                 880 


Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu 
                885                 890                 895     


Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu 
            900                 905                 910         


Ile Asn Ser Arg Ser Ser Gly Ser Gly Ser Gln Tyr Leu Pro Asp Thr 
        915                 920                 925             


Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu Thr 
    930                 935                 940                 


Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp Pro 
945                 950                 955                 960 


Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala Ser 
                965                 970                 975     


Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu Ser 
            980                 985                 990         


Thr Ile Asn Tyr Asp Glu Phe Pro  Thr Met Val Phe Pro  Ser Gly Gln 
        995                 1000                 1005             


Ile Ser  Gln Ala Ser Ala Leu  Ala Pro Ala Pro Pro  Gln Val Leu 
    1010                 1015                 1020             


Pro Gln  Ala Pro Ala Pro Ala  Pro Ala Pro Ala Met  Val Ser Ala 
    1025                 1030                 1035             


Leu Ala  Gln Ala Pro Ala Pro  Val Pro Val Leu Ala  Pro Gly Pro 
    1040                 1045                 1050             


Pro Gln  Ala Val Ala Pro Pro  Ala Pro Lys Pro Thr  Gln Ala Gly 
    1055                 1060                 1065             


Glu Gly  Thr Leu Ser Glu Ala  Leu Leu Gln Leu Gln  Phe Asp Asp 
    1070                 1075                 1080             


Glu Asp  Leu Gly Ala Leu Leu  Gly Asn Ser Thr Asp  Pro Ala Val 
    1085                 1090                 1095             


Phe Thr  Asp Leu Ala Ser Val  Asp Asn Ser Glu Phe  Gln Gln Leu 
    1100                 1105                 1110             


Leu Asn  Gln Gly Ile Pro Val  Ala Pro His Thr Thr  Glu Pro Met 
    1115                 1120                 1125             


Leu Met  Glu Tyr Pro Glu Ala  Ile Thr Arg Leu Val  Thr Gly Ala 
    1130                 1135                 1140             


Gln Arg  Pro Pro Asp Pro Ala  Pro Ala Pro Leu Gly  Ala Pro Gly 
    1145                 1150                 1155             


Leu Pro  Asn Gly Leu Leu Ser  Gly Asp Glu Asp Phe  Ser Ser Ile 
    1160                 1165                 1170             


Ala Asp  Met Asp Phe Ser Ala  Leu Leu Gly Ser Gly  Ser Gly Ser 
    1175                 1180                 1185             


Arg Asp  Ser Arg Glu Gly Met  Phe Leu Pro Lys Pro  Glu Ala Gly 
    1190                 1195                 1200             


Ser Ala  Ile Ser Asp Val Phe  Glu Gly Arg Glu Val  Cys Gln Pro 
    1205                 1210                 1215             


Lys Arg  Ile Arg Pro Phe His  Pro Pro Gly Ser Pro  Trp Ala Asn 
    1220                 1225                 1230             


Arg Pro  Leu Pro Ala Ser Leu  Ala Pro Thr Pro Thr  Gly Pro Val 
    1235                 1240                 1245             


His Glu  Pro Val Gly Ser Leu  Thr Pro Ala Pro Val  Pro Gln Pro 
    1250                 1255                 1260             


Leu Asp  Pro Ala Pro Ala Val  Thr Pro Glu Ala Ser  His Leu Leu 
    1265                 1270                 1275             


Glu Asp  Pro Asp Glu Glu Thr  Ser Gln Ala Val Lys  Ala Leu Arg 
    1280                 1285                 1290             


Glu Met  Ala Asp Thr Val Ile  Pro Gln Lys Glu Glu  Ala Ala Ile 
    1295                 1300                 1305             


Cys Gly  Gln Met Asp Leu Ser  His Pro Pro Pro Arg  Gly His Leu 
    1310                 1315                 1320             


Asp Glu  Leu Thr Thr Thr Leu  Glu Ser Met Thr Glu  Asp Leu Asn 
    1325                 1330                 1335             


Leu Asp  Ser Pro Leu Thr Pro  Glu Leu Asn Glu Ile  Leu Asp Thr 
    1340                 1345                 1350             


Phe Leu  Asn Asp Glu Cys Leu  Leu His Ala Met His  Ile Ser Thr 
    1355                 1360                 1365             


Gly Leu  Ser Ile Phe Asp Thr  Ser Leu Phe 
    1370                 1375             


<210> 57
<211> 1355
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Asn Asn Asp Val Pro Phe Tyr Asn Gly Asn Glu Asp Thr Phe Val 
        35                  40                  45              


Lys Ser Ala Gln Leu Gln Met Pro Gly Lys Tyr Phe Arg Pro Gly Ser 
    50                  55                  60                  


Tyr Ser Pro Gln Gly Thr Asp Leu Met Tyr Lys Gly Asp Ile His Tyr 
65                  70                  75                  80  


Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn 
                85                  90                  95      


Leu Val Gln Gly Asn Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ser Asn 
            100                 105                 110         


Glu Gly Tyr Phe Asn Ser Ser Val Pro Val Gly Asp Arg Met Val Thr 
        115                 120                 125             


Glu Ile Glu Arg Val Thr Glu Pro Ile Ile Ser Asn Lys Tyr Trp Gly 
    130                 135                 140                 


Asn Pro Glu Phe Val Leu Gly Asn Ile Lys Glu His Ile Ile Arg Asn 
145                 150                 155                 160 


Asp Lys Thr Asn Glu Met Tyr Gly Gln Phe Tyr Trp Ile Arg Asp Ile 
                165                 170                 175     


Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Asp Asn Val 
            180                 185                 190         


Asn Asn Tyr Asn Leu Trp Tyr Val Arg Thr Ser Lys Pro Glu Leu Lys 
        195                 200                 205             


Glu Phe Lys Ala Ser Ser Gly Lys Lys Asp Asp Pro Val Lys Phe Ile 
    210                 215                 220                 


Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg 
225                 230                 235                 240 


Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ser Glu Ala Gly Glu 
                245                 250                 255     


Arg Asn Arg Val Lys Trp Met Leu Asp Ile Ile Lys Asn Gly Glu Thr 
            260                 265                 270         


Val His His Gln Gly Asn Tyr Leu Arg Ser Asn Pro Gln Lys Asn Asn 
        275                 280                 285             


Asp Lys Pro Asn Glu Gly Asp Ala Gly Tyr Phe Ser Lys Glu Gly Ile 
    290                 295                 300                 


Pro Phe Tyr Pro Gln Glu Cys Gly Arg Tyr Thr Ala Lys Leu Lys Leu 
305                 310                 315                 320 


Ile Asp Ala Val Gln Arg Glu Ser Thr Glu Lys Val Val Asp Phe Val 
                325                 330                 335     


Val Asp Gly Ser Cys Gly Thr Gln Val Pro Pro Thr Thr Asp Pro Val 
            340                 345                 350         


Asp Gly Glu Phe Asn Tyr Lys Ile Asp Tyr Ser Ala Asp Arg Ile Glu 
        355                 360                 365             


Gly Glu Thr Ala Arg Lys Asp Lys Glu Ile Lys Thr Arg Val Asp Val 
    370                 375                 380                 


Ser Arg Ala Ser Phe Lys Glu Glu His Asp Gln Tyr Arg Ala Lys Leu 
385                 390                 395                 400 


Asp Glu Glu Phe Lys Lys Tyr Gln Lys Glu Val Asp Ala Tyr Ile Ser 
                405                 410                 415     


Glu Arg Asp Ser Ala Gln Asp Ser Leu Asn Tyr Cys Arg Arg Asn Pro 
            420                 425                 430         


Ile Arg Glu Glu Asp Glu Lys Gly Gly Val His Tyr Arg Asp Arg Asp 
        435                 440                 445             


Cys Ser Trp Glu Glu Asn Asn Leu Asp Asn Val Val Ser Lys Leu Glu 
    450                 455                 460                 


Lys Ala Lys Gln Asn Arg Glu Lys Leu Ser Lys Lys Leu Gly Asp Phe 
465                 470                 475                 480 


Asp Lys Leu Asn Ala Gln Tyr His Asn Pro Glu Val Thr Val Ile Leu 
                485                 490                 495     


Lys His Asn Gly Lys Lys Val Glu Ser Lys Thr Val Arg Leu Lys Glu 
            500                 505                 510         


Gly Glu Lys Lys Thr Val Phe Phe Asn Trp Glu His Lys Gly Lys Gly 
        515                 520                 525             


Thr Ile Gln Ala Glu Ile Asn Pro Ala Asp Glu Asp Gly Ser Arg Leu 
    530                 535                 540                 


Asp Ile Lys Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile 
545                 550                 555                 560 


Tyr Glu Pro Ser Gln Glu Lys Ala Met Cys Gly Ala Thr Ser Val Lys 
                565                 570                 575     


Gly Val Val Glu Thr Val Ser Asn Arg Val Ser Val Glu Asp Thr Val 
            580                 585                 590         


Gly Glu Met Tyr His Glu Thr Leu Thr Gly Ser Ile Asp Lys Leu Val 
        595                 600                 605             


Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Thr Tyr Glu Leu Asp Gly 
    610                 615                 620                 


Lys Tyr Thr Asn Asn Trp Asp Gln Asn Tyr Gln Gly Val Phe Thr Val 
625                 630                 635                 640 


Ala Thr Ala Lys Tyr Pro Phe Ala Asp Glu Gly Leu Lys Leu Asn Gln 
                645                 650                 655     


Asp Leu Glu Lys Lys Glu Ile Lys Asp Asn Thr Ser Lys Phe Ile Pro 
            660                 665                 670         


Lys Asn Met Tyr Leu Ser Glu Lys Thr Gly Tyr Val Phe Asp Ser Lys 
        675                 680                 685             


Arg Pro Ile Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp 
    690                 695                 700                 


Gly Gly His Lys Trp Tyr Ala Pro Met Lys Thr Lys Asp Gly Lys Tyr 
705                 710                 715                 720 


Ser Phe Lys Val Glu Thr Lys Pro Thr Gly Ile Asn Glu Met Ser Leu 
                725                 730                 735     


Cys Met Thr Glu Glu Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe 
            740                 745                 750         


Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly 
        755                 760                 765             


Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr 
    770                 775                 780                 


Asp Trp Tyr Tyr Met Lys Asn Gly Asn Lys Asn Lys Ile Lys Arg Pro 
785                 790                 795                 800 


Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Gly Arg Leu 
                805                 810                 815     


Asp Ala Leu Ile Ser Thr Ser Leu Tyr Lys Lys Ala Gly Tyr Lys Glu 
            820                 825                 830         


Ala Ser Gly Ser Gly Arg Ala Asp Ala Leu Asp Asp Phe Asp Leu Asp 
        835                 840                 845             


Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly 
    850                 855                 860                 


Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala 
865                 870                 875                 880 


Leu Asp Asp Phe Asp Leu Asp Met Leu Ile Asn Ser Arg Ser Ser Gly 
                885                 890                 895     


Ser Gly Ser Gln Tyr Leu Pro Asp Thr Asp Asp Arg His Arg Ile Glu 
            900                 905                 910         


Glu Lys Arg Lys Arg Thr Tyr Glu Thr Phe Lys Ser Ile Met Lys Lys 
        915                 920                 925             


Ser Pro Phe Ser Gly Pro Thr Asp Pro Arg Pro Pro Pro Arg Arg Ile 
    930                 935                 940                 


Ala Val Pro Ser Arg Ser Ser Ala Ser Val Pro Lys Pro Ala Pro Gln 
945                 950                 955                 960 


Pro Tyr Pro Phe Thr Ser Ser Leu Ser Thr Ile Asn Tyr Asp Glu Phe 
                965                 970                 975     


Pro Thr Met Val Phe Pro Ser Gly Gln Ile Ser Gln Ala Ser Ala Leu 
            980                 985                 990         


Ala Pro Ala Pro Pro Gln Val Leu  Pro Gln Ala Pro Ala  Pro Ala Pro 
        995                 1000                 1005             


Ala Pro  Ala Met Val Ser Ala  Leu Ala Gln Ala Pro  Ala Pro Val 
    1010                 1015                 1020             


Pro Val  Leu Ala Pro Gly Pro  Pro Gln Ala Val Ala  Pro Pro Ala 
    1025                 1030                 1035             


Pro Lys  Pro Thr Gln Ala Gly  Glu Gly Thr Leu Ser  Glu Ala Leu 
    1040                 1045                 1050             


Leu Gln  Leu Gln Phe Asp Asp  Glu Asp Leu Gly Ala  Leu Leu Gly 
    1055                 1060                 1065             


Asn Ser  Thr Asp Pro Ala Val  Phe Thr Asp Leu Ala  Ser Val Asp 
    1070                 1075                 1080             


Asn Ser  Glu Phe Gln Gln Leu  Leu Asn Gln Gly Ile  Pro Val Ala 
    1085                 1090                 1095             


Pro His  Thr Thr Glu Pro Met  Leu Met Glu Tyr Pro  Glu Ala Ile 
    1100                 1105                 1110             


Thr Arg  Leu Val Thr Gly Ala  Gln Arg Pro Pro Asp  Pro Ala Pro 
    1115                 1120                 1125             


Ala Pro  Leu Gly Ala Pro Gly  Leu Pro Asn Gly Leu  Leu Ser Gly 
    1130                 1135                 1140             


Asp Glu  Asp Phe Ser Ser Ile  Ala Asp Met Asp Phe  Ser Ala Leu 
    1145                 1150                 1155             


Leu Gly  Ser Gly Ser Gly Ser  Arg Asp Ser Arg Glu  Gly Met Phe 
    1160                 1165                 1170             


Leu Pro  Lys Pro Glu Ala Gly  Ser Ala Ile Ser Asp  Val Phe Glu 
    1175                 1180                 1185             


Gly Arg  Glu Val Cys Gln Pro  Lys Arg Ile Arg Pro  Phe His Pro 
    1190                 1195                 1200             


Pro Gly  Ser Pro Trp Ala Asn  Arg Pro Leu Pro Ala  Ser Leu Ala 
    1205                 1210                 1215             


Pro Thr  Pro Thr Gly Pro Val  His Glu Pro Val Gly  Ser Leu Thr 
    1220                 1225                 1230             


Pro Ala  Pro Val Pro Gln Pro  Leu Asp Pro Ala Pro  Ala Val Thr 
    1235                 1240                 1245             


Pro Glu  Ala Ser His Leu Leu  Glu Asp Pro Asp Glu  Glu Thr Ser 
    1250                 1255                 1260             


Gln Ala  Val Lys Ala Leu Arg  Glu Met Ala Asp Thr  Val Ile Pro 
    1265                 1270                 1275             


Gln Lys  Glu Glu Ala Ala Ile  Cys Gly Gln Met Asp  Leu Ser His 
    1280                 1285                 1290             


Pro Pro  Pro Arg Gly His Leu  Asp Glu Leu Thr Thr  Thr Leu Glu 
    1295                 1300                 1305             


Ser Met  Thr Glu Asp Leu Asn  Leu Asp Ser Pro Leu  Thr Pro Glu 
    1310                 1315                 1320             


Leu Asn  Glu Ile Leu Asp Thr  Phe Leu Asn Asp Glu  Cys Leu Leu 
    1325                 1330                 1335             


His Ala  Met His Ile Ser Thr  Gly Leu Ser Ile Phe  Asp Thr Ser 
    1340                 1345                 1350             


Leu Phe  
    1355 


<210> 58
<211> 1377
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 58
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        35                  40                  45              


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
    50                  55                  60                  


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
65                  70                  75                  80  


Leu Ile Asn Ser Arg Ser Ser Gly Ser Gly Ser Gln Tyr Leu Pro Asp 
                85                  90                  95      


Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu 
            100                 105                 110         


Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp 
        115                 120                 125             


Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala 
    130                 135                 140                 


Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu 
145                 150                 155                 160 


Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly 
                165                 170                 175     


Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu 
            180                 185                 190         


Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu 
        195                 200                 205             


Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln 
    210                 215                 220                 


Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr 
225                 230                 235                 240 


Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly 
                245                 250                 255     


Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala 
            260                 265                 270         


Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro 
        275                 280                 285             


Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala 
    290                 295                 300                 


Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp 
                325                 330                 335     


Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Gly 
            340                 345                 350         


Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys 
        355                 360                 365             


Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val 
    370                 375                 380                 


Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp 
385                 390                 395                 400 


Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro 
                405                 410                 415     


Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro 
            420                 425                 430         


Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu 
        435                 440                 445             


Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met 
    450                 455                 460                 


Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln 
465                 470                 475                 480 


Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr 
                485                 490                 495     


Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu 
            500                 505                 510         


Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys 
        515                 520                 525             


Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr 
    530                 535                 540                 


Ser Leu Phe Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr 
545                 550                 555                 560 


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser 
                565                 570                 575     


Gly Gly Ser Met Lys Leu Lys Arg Gly Leu Leu Val Leu Cys Thr Ser 
            580                 585                 590         


Thr Ala Leu Ile Tyr Pro Ser Ile Val Asn Ala Lys Asn Asn Asp Val 
        595                 600                 605             


Pro Phe Tyr Asp Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys Tyr Leu 
    610                 615                 620                 


Gln Leu Pro Gly Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala Ser Lys 
625                 630                 635                 640 


Glu Ser Leu Tyr Arg Ala Asp Ile His Phe Pro Ala Val Tyr Asn Gly 
                645                 650                 655     


Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Ala Glu Asp 
            660                 665                 670         


Ser Ser Glu Pro Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu Asn Gly 
        675                 680                 685             


Ser Val Pro Ala Gly Asp Arg Met Val Thr Glu Val Glu Arg Ile Asn 
    690                 695                 700                 


Lys Tyr Val Ile Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe Val Leu 
705                 710                 715                 720 


Asp Asn Ile Asp Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr Lys Glu 
                725                 730                 735     


Leu Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly 
            740                 745                 750         


Tyr Ala Gly Ala Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser Leu Trp 
        755                 760                 765             


Tyr Val Arg Thr Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala Ser Ser 
    770                 775                 780                 


Ser Thr Lys Asp Val Pro Val Lys Phe Thr Phe Asn Gly Phe Glu Tyr 
785                 790                 795                 800 


Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr 
                805                 810                 815     


Val Asn Pro Tyr Gln Ala Ala Ala Gly Glu Arg Asn Arg Val Lys Trp 
            820                 825                 830         


Met Leu Asp Ile Thr Lys Asp Gly Glu Thr Val His His Gln Glu Asn 
        835                 840                 845             


Tyr Leu Arg Ser Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn Glu Gly 
    850                 855                 860                 


Asp Ala Gly Lys Phe Val Lys Asp Asp Val Lys Trp Gln Pro Gln Met 
865                 870                 875                 880 


Cys Gly Gln Tyr Thr Ala Lys Ile Lys Val Leu Asp Ala Val Gln Arg 
                885                 890                 895     


Glu Ser Asn Glu Lys Asn Val Asp Phe Thr Ile Asp Gly Asn Cys Gly 
            900                 905                 910         


Asn Glu Val Thr Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp Phe Lys 
        915                 920                 925             


Tyr Ile Ile Asp Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg 
    930                 935                 940                 


Glu Gly Lys Asn Ile Lys Thr Arg Val Asp Val Ser Arg Asp Asn Phe 
945                 950                 955                 960 


Lys Pro Glu Arg Asp Gln Tyr Arg Val Lys Val Asn Asn Asn Ile Asn 
                965                 970                 975     


Lys Ser Gln Gln Glu Val Asn Ser Ser Glu Ser Glu Arg Asp Ser Ala 
            980                 985                 990         


Gln Ser Ser Leu Ser Tyr Cys Arg  Arg Asn Pro Ile His  Glu Val Asp 
        995                 1000                 1005             


Ala Glu  Gly Lys Asp His Tyr  Tyr Asp Arg Asp Cys  Ser Trp Glu 
    1010                 1015                 1020             


Glu Asn  Lys Leu Asp Ser Ala  Ala Ser Lys Leu Asp  Asn Ala Arg 
    1025                 1030                 1035             


Gln Lys  Phe Glu Lys Glu Lys  Asn Lys Leu Lys Lys  Leu Asp Val 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Thr Asn  Pro Glu Thr Val Val  Val Leu Lys 
    1055                 1060                 1065             


His Asn  Gly Gln Gln Val Ala  Leu Gln Lys Val Arg  Leu Thr Glu 
    1070                 1075                 1080             


Gly Glu  Lys Lys Thr Leu Asn  Leu Asp Trp Gln His  Lys Gly Lys 
    1085                 1090                 1095             


Gly Thr  Ile Gln Ala Glu Ile  Asn Pro Ala Gly Asn  Arg Ile Asp 
    1100                 1105                 1110             


Ile Glu  Glu Thr Thr Tyr Lys  Asn Asn Pro Ile Lys  Thr Ala Ile 
    1115                 1120                 1125             


Tyr Glu  Pro Ser Lys Glu Lys  Ala Met Cys Gly Val  Thr Ser Val 
    1130                 1135                 1140             


Lys Gly  Val Val Glu Thr Val  Ser Glu Arg Val Ser  Lys Glu Asp 
    1145                 1150                 1155             


Ile Thr  Gly Glu Met Tyr Tyr  Glu Thr Leu Thr Gly  Ser Ile Asp 
    1160                 1165                 1170             


Asn Leu  Ala Pro Ser Lys Leu  His Ser Gly Tyr Gly  Phe Ser Tyr 
    1175                 1180                 1185             


Glu Val  Asn Gly Lys Tyr Lys  Asn Asp Trp Asn Ala  Asn Tyr Pro 
    1190                 1195                 1200             


Gly Val  Phe Thr Ala Ala Lys  Ala Gln Tyr Pro Phe  Ala Asp Glu 
    1205                 1210                 1215             


Gly Leu  Lys Ser Thr Gln Asp  Leu Glu Lys Lys Glu  Leu Lys Asp 
    1220                 1225                 1230             


Asn Thr  Ala Lys Phe Leu Pro  Lys Asn Met Tyr Leu  Ser Glu Ala 
    1235                 1240                 1245             


Thr Gly  His Val Phe Asp Ser  Lys Arg Pro Thr Lys  Ser Leu Tyr 
    1250                 1255                 1260             


Trp Asp  Gly Gln Glu Lys Ile  Ile Asp Gly Gly Gln  Lys Trp Tyr 
    1265                 1270                 1275             


Ser Pro  Leu Lys Thr Lys Asp  Gly Val Tyr Thr Phe  Asn Val Glu 
    1280                 1285                 1290             


Thr Ala  Pro Ala Gly Ile Asn  Glu Met Ser Leu Cys  Leu Thr Glu 
    1295                 1300                 1305             


Gln Val  Glu Ile Lys Gly Val  Ala Tyr Asp Asp Phe  Ile Lys Arg 
    1310                 1315                 1320             


Arg Val  Phe Pro Asp Asp Pro  Phe Pro Gly Gly Ser  Gly Val Gly 
    1325                 1330                 1335             


Trp Asn  Trp Val Gly Lys Glu  Glu Leu Leu His Lys  Leu Thr Asp 
    1340                 1345                 1350             


Trp Tyr  Tyr Met Lys Thr Gly  Lys Lys Arg Pro Ala  Ala Thr Lys 
    1355                 1360                 1365             


Lys Ala  Gly Gln Ala Lys Lys  Lys Lys 
    1370                 1375         


<210> 59
<211> 1354
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        35                  40                  45              


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
    50                  55                  60                  


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
65                  70                  75                  80  


Leu Ile Asn Ser Arg Ser Ser Gly Ser Gly Ser Gln Tyr Leu Pro Asp 
                85                  90                  95      


Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu 
            100                 105                 110         


Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp 
        115                 120                 125             


Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala 
    130                 135                 140                 


Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu 
145                 150                 155                 160 


Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly 
                165                 170                 175     


Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu 
            180                 185                 190         


Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu 
        195                 200                 205             


Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln 
    210                 215                 220                 


Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr 
225                 230                 235                 240 


Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly 
                245                 250                 255     


Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala 
            260                 265                 270         


Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro 
        275                 280                 285             


Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala 
    290                 295                 300                 


Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp 
                325                 330                 335     


Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Gly 
            340                 345                 350         


Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys 
        355                 360                 365             


Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val 
    370                 375                 380                 


Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp 
385                 390                 395                 400 


Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro 
                405                 410                 415     


Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro 
            420                 425                 430         


Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu 
        435                 440                 445             


Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met 
    450                 455                 460                 


Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln 
465                 470                 475                 480 


Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr 
                485                 490                 495     


Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu 
            500                 505                 510         


Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys 
        515                 520                 525             


Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr 
    530                 535                 540                 


Ser Leu Phe Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr 
545                 550                 555                 560 


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser 
                565                 570                 575     


Gly Gly Ser Met Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn 
            580                 585                 590         


Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe 
        595                 600                 605             


Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp 
    610                 615                 620                 


Ile His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro 
625                 630                 635                 640 


Lys Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg 
                645                 650                 655     


Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg 
            660                 665                 670         


Met Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys 
        675                 680                 685             


Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser 
    690                 695                 700                 


Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile 
705                 710                 715                 720 


Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val 
                725                 730                 735     


Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro 
            740                 745                 750         


Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val 
        755                 760                 765             


Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr 
    770                 775                 780                 


Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala 
785                 790                 795                 800 


Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp 
                805                 810                 815     


Gly Glu Thr Val His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln 
            820                 825                 830         


Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys 
        835                 840                 845             


Asp Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys 
    850                 855                 860                 


Ile Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val 
865                 870                 875                 880 


Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro 
                885                 890                 895     


Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala 
            900                 905                 910         


Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr 
        915                 920                 925             


Arg Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr 
    930                 935                 940                 


Arg Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn 
945                 950                 955                 960 


Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys 
                965                 970                 975     


Arg Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr 
            980                 985                 990         


Tyr Asp Arg Asp Cys Ser Trp Glu  Glu Asn Lys Leu Asp  Ser Ala Ala 
        995                 1000                 1005             


Ser Lys  Leu Asp Asn Ala Arg  Gln Lys Phe Glu Lys  Glu Lys Asn 
    1010                 1015                 1020             


Lys Leu  Lys Lys Leu Asp Val  Leu Glu Glu Lys Tyr  Thr Asn Pro 
    1025                 1030                 1035             


Glu Thr  Val Val Val Leu Lys  His Asn Gly Gln Gln  Val Ala Leu 
    1040                 1045                 1050             


Gln Lys  Val Arg Leu Thr Glu  Gly Glu Lys Lys Thr  Leu Asn Leu 
    1055                 1060                 1065             


Asp Trp  Gln His Lys Gly Lys  Gly Thr Ile Gln Ala  Glu Ile Asn 
    1070                 1075                 1080             


Pro Ala  Gly Asn Arg Ile Asp  Ile Glu Glu Thr Thr  Tyr Lys Asn 
    1085                 1090                 1095             


Asn Pro  Ile Lys Thr Ala Ile  Tyr Glu Pro Ser Lys  Glu Lys Ala 
    1100                 1105                 1110             


Met Cys  Gly Val Thr Ser Val  Lys Gly Val Val Glu  Thr Val Ser 
    1115                 1120                 1125             


Glu Arg  Val Ser Lys Glu Asp  Ile Thr Gly Glu Met  Tyr Tyr Glu 
    1130                 1135                 1140             


Thr Leu  Thr Gly Ser Ile Asp  Asn Leu Ala Pro Ser  Lys Leu His 
    1145                 1150                 1155             


Ser Gly  Tyr Gly Phe Ser Tyr  Glu Val Asn Gly Lys  Tyr Lys Asn 
    1160                 1165                 1170             


Asp Trp  Asn Ala Asn Tyr Pro  Gly Val Phe Thr Ala  Ala Lys Ala 
    1175                 1180                 1185             


Gln Tyr  Pro Phe Ala Asp Glu  Gly Leu Lys Ser Thr  Gln Asp Leu 
    1190                 1195                 1200             


Glu Lys  Lys Glu Leu Lys Asp  Asn Thr Ala Lys Phe  Leu Pro Lys 
    1205                 1210                 1215             


Asn Met  Tyr Leu Ser Glu Ala  Thr Gly His Val Phe  Asp Ser Lys 
    1220                 1225                 1230             


Arg Pro  Thr Lys Ser Leu Tyr  Trp Asp Gly Gln Glu  Lys Ile Ile 
    1235                 1240                 1245             


Asp Gly  Gly Gln Lys Trp Tyr  Ser Pro Leu Lys Thr  Lys Asp Gly 
    1250                 1255                 1260             


Val Tyr  Thr Phe Asn Val Glu  Thr Ala Pro Ala Gly  Ile Asn Glu 
    1265                 1270                 1275             


Met Ser  Leu Cys Leu Thr Glu  Gln Val Glu Ile Lys  Gly Val Ala 
    1280                 1285                 1290             


Tyr Asp  Asp Phe Ile Lys Arg  Arg Val Phe Pro Asp  Asp Pro Phe 
    1295                 1300                 1305             


Pro Gly  Gly Ser Gly Val Gly  Trp Asn Trp Val Gly  Lys Glu Glu 
    1310                 1315                 1320             


Leu Leu  His Lys Leu Thr Asp  Trp Tyr Tyr Met Lys  Thr Gly Lys 
    1325                 1330                 1335             


Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly Gln Ala  Lys Lys Lys 
    1340                 1345                 1350             


Lys 
    


<210> 60
<211> 1377
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 60
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        35                  40                  45              


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
    50                  55                  60                  


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
65                  70                  75                  80  


Leu Ile Asn Ser Arg Ser Ser Gly Ser Gly Ser Gln Tyr Leu Pro Asp 
                85                  90                  95      


Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu 
            100                 105                 110         


Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp 
        115                 120                 125             


Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala 
    130                 135                 140                 


Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu 
145                 150                 155                 160 


Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly 
                165                 170                 175     


Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu 
            180                 185                 190         


Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu 
        195                 200                 205             


Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln 
    210                 215                 220                 


Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr 
225                 230                 235                 240 


Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly 
                245                 250                 255     


Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala 
            260                 265                 270         


Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro 
        275                 280                 285             


Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala 
    290                 295                 300                 


Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp 
                325                 330                 335     


Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Gly 
            340                 345                 350         


Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys 
        355                 360                 365             


Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val 
    370                 375                 380                 


Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp 
385                 390                 395                 400 


Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro 
                405                 410                 415     


Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro 
            420                 425                 430         


Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu 
        435                 440                 445             


Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met 
    450                 455                 460                 


Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln 
465                 470                 475                 480 


Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr 
                485                 490                 495     


Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu 
            500                 505                 510         


Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys 
        515                 520                 525             


Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr 
    530                 535                 540                 


Ser Leu Phe Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr 
545                 550                 555                 560 


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser 
                565                 570                 575     


Gly Gly Ser Met Lys Leu Lys Arg Gly Leu Leu Val Leu Cys Thr Ser 
            580                 585                 590         


Thr Ala Leu Ile Tyr Pro Ser Ile Val Asn Ala Lys Asn Asn Asp Val 
        595                 600                 605             


Pro Phe Tyr Asp Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys Tyr Leu 
    610                 615                 620                 


Gln Leu Pro Gly Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala Ser Lys 
625                 630                 635                 640 


Glu Ser Leu Tyr Arg Ala Asp Ile His Phe Pro Ala Val Tyr Asn Gly 
                645                 650                 655     


Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Ala Glu Asp 
            660                 665                 670         


Ser Ser Glu Pro Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu Asn Gly 
        675                 680                 685             


Ser Val Pro Ala Gly Asp Arg Met Val Thr Glu Val Glu Arg Ile Asn 
    690                 695                 700                 


Lys Tyr Val Ile Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe Val Leu 
705                 710                 715                 720 


Asp Asn Ile Asp Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr Lys Glu 
                725                 730                 735     


Leu Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly 
            740                 745                 750         


Tyr Ala Gly Ala Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser Leu Trp 
        755                 760                 765             


Tyr Val Arg Thr Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala Ser Ser 
    770                 775                 780                 


Ser Thr Lys Asp Val Pro Val Lys Phe Thr Phe Asn Gly Phe Glu Tyr 
785                 790                 795                 800 


Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr 
                805                 810                 815     


Val Asn Pro Tyr Gln Ala Ala Ala Gly Glu Arg Asn Arg Val Lys Trp 
            820                 825                 830         


Met Leu Asp Ile Thr Lys Asp Gly Glu Thr Val His His Gln Glu Asn 
        835                 840                 845             


Tyr Leu Arg Ser Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn Glu Gly 
    850                 855                 860                 


Asp Ala Gly Lys Phe Val Lys Asp Asp Val Lys Trp Gln Pro Gln Met 
865                 870                 875                 880 


Cys Gly Gln Tyr Thr Ala Lys Ile Lys Val Leu Asp Ala Val Gln Arg 
                885                 890                 895     


Glu Ser Asn Glu Lys Asn Val Asp Phe Thr Ile Asp Gly Asn Cys Gly 
            900                 905                 910         


Asn Glu Val Thr Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp Phe Lys 
        915                 920                 925             


Tyr Ile Ile Asp Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg 
    930                 935                 940                 


Glu Gly Lys Asn Ile Lys Thr Arg Val Asp Val Ser Arg Asp Asn Phe 
945                 950                 955                 960 


Lys Pro Glu Arg Asp Gln Tyr Arg Val Lys Val Asn Asn Asn Ile Asn 
                965                 970                 975     


Lys Ser Gln Gln Glu Val Asn Ser Ser Glu Ser Glu Arg Asp Ser Ala 
            980                 985                 990         


Gln Ser Ser Leu Ser Tyr Cys Arg  Arg Asn Pro Ile His  Glu Val Asp 
        995                 1000                 1005             


Ala Glu  Gly Lys Asp His Tyr  Tyr Asp Arg Asp Cys  Ser Trp Glu 
    1010                 1015                 1020             


Glu Asn  Lys Leu Asp Ser Ala  Ala Ser Lys Leu Asp  Asn Ala Arg 
    1025                 1030                 1035             


Gln Lys  Phe Glu Lys Glu Lys  Asn Lys Leu Lys Lys  Leu Asp Val 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Thr Asn  Pro Glu Thr Val Val  Val Leu Lys 
    1055                 1060                 1065             


His Asn  Gly Gln Gln Val Ala  Leu Gln Lys Val Arg  Leu Thr Glu 
    1070                 1075                 1080             


Gly Glu  Lys Lys Thr Leu Asn  Leu Asp Trp Gln His  Lys Gly Lys 
    1085                 1090                 1095             


Gly Thr  Ile Gln Ala Glu Ile  Asn Pro Ala Gly Asn  Arg Ile Asp 
    1100                 1105                 1110             


Ile Glu  Glu Thr Thr Tyr Lys  Asn Asn Pro Ile Lys  Thr Ala Ile 
    1115                 1120                 1125             


Tyr Glu  Pro Ser Lys Glu Lys  Ala Met Cys Gly Val  Thr Ser Val 
    1130                 1135                 1140             


Lys Gly  Val Val Glu Thr Val  Ser Glu Arg Val Ser  Lys Glu Asp 
    1145                 1150                 1155             


Ile Thr  Gly Glu Met Tyr Tyr  Glu Thr Leu Thr Gly  Ser Ile Asp 
    1160                 1165                 1170             


Asn Leu  Ala Pro Ser Lys Leu  His Ser Gly Tyr Gly  Phe Ser Tyr 
    1175                 1180                 1185             


Glu Val  Asn Gly Lys Tyr Lys  Asn Asp Trp Asn Ala  Asn Tyr Pro 
    1190                 1195                 1200             


Gly Val  Phe Thr Ala Ala Lys  Ala Gln Tyr Pro Phe  Ala Asp Glu 
    1205                 1210                 1215             


Gly Leu  Lys Ser Thr Gln Asp  Leu Glu Lys Lys Glu  Leu Lys Asp 
    1220                 1225                 1230             


Asn Thr  Ala Lys Phe Leu Pro  Lys Asn Met Tyr Leu  Ser Glu Ala 
    1235                 1240                 1245             


Thr Gly  His Val Phe Asp Ser  Lys Arg Pro Thr Lys  Ser Leu Tyr 
    1250                 1255                 1260             


Trp Asp  Gly Gln Glu Lys Ile  Ile Asp Gly Gly Gln  Lys Trp Tyr 
    1265                 1270                 1275             


Ser Pro  Leu Lys Thr Lys Asp  Gly Val Tyr Thr Phe  Asn Val Glu 
    1280                 1285                 1290             


Thr Ala  Pro Ala Gly Ile Asn  Glu Met Ser Leu Cys  Leu Thr Glu 
    1295                 1300                 1305             


Gln Val  Glu Ile Lys Gly Val  Ala Tyr Asp Asp Phe  Ile Lys Arg 
    1310                 1315                 1320             


Arg Val  Phe Pro Asp Asp Pro  Phe Pro Gly Gly Ser  Gly Val Gly 
    1325                 1330                 1335             


Trp Asn  Trp Val Gly Lys Glu  Glu Leu Leu His Lys  Leu Thr Asp 
    1340                 1345                 1350             


Trp Tyr  Tyr Met Lys Thr Gly  Lys Lys Arg Pro Ala  Ala Thr Lys 
    1355                 1360                 1365             


Lys Ala  Gly Gln Ala Lys Lys  Lys Lys 
    1370                 1375         


<210> 61
<211> 1361
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Asp 
            20                  25                  30          


Ala Leu Asp Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp 
        35                  40                  45              


Asp Phe Asp Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp 
    50                  55                  60                  


Leu Asp Met Leu Gly Ser Asp Ala Leu Asp Asp Phe Asp Leu Asp Met 
65                  70                  75                  80  


Leu Ile Asn Ser Arg Ser Ser Gly Ser Gly Ser Gln Tyr Leu Pro Asp 
                85                  90                  95      


Thr Asp Asp Arg His Arg Ile Glu Glu Lys Arg Lys Arg Thr Tyr Glu 
            100                 105                 110         


Thr Phe Lys Ser Ile Met Lys Lys Ser Pro Phe Ser Gly Pro Thr Asp 
        115                 120                 125             


Pro Arg Pro Pro Pro Arg Arg Ile Ala Val Pro Ser Arg Ser Ser Ala 
    130                 135                 140                 


Ser Val Pro Lys Pro Ala Pro Gln Pro Tyr Pro Phe Thr Ser Ser Leu 
145                 150                 155                 160 


Ser Thr Ile Asn Tyr Asp Glu Phe Pro Thr Met Val Phe Pro Ser Gly 
                165                 170                 175     


Gln Ile Ser Gln Ala Ser Ala Leu Ala Pro Ala Pro Pro Gln Val Leu 
            180                 185                 190         


Pro Gln Ala Pro Ala Pro Ala Pro Ala Pro Ala Met Val Ser Ala Leu 
        195                 200                 205             


Ala Gln Ala Pro Ala Pro Val Pro Val Leu Ala Pro Gly Pro Pro Gln 
    210                 215                 220                 


Ala Val Ala Pro Pro Ala Pro Lys Pro Thr Gln Ala Gly Glu Gly Thr 
225                 230                 235                 240 


Leu Ser Glu Ala Leu Leu Gln Leu Gln Phe Asp Asp Glu Asp Leu Gly 
                245                 250                 255     


Ala Leu Leu Gly Asn Ser Thr Asp Pro Ala Val Phe Thr Asp Leu Ala 
            260                 265                 270         


Ser Val Asp Asn Ser Glu Phe Gln Gln Leu Leu Asn Gln Gly Ile Pro 
        275                 280                 285             


Val Ala Pro His Thr Thr Glu Pro Met Leu Met Glu Tyr Pro Glu Ala 
    290                 295                 300                 


Ile Thr Arg Leu Val Thr Gly Ala Gln Arg Pro Pro Asp Pro Ala Pro 
305                 310                 315                 320 


Ala Pro Leu Gly Ala Pro Gly Leu Pro Asn Gly Leu Leu Ser Gly Asp 
                325                 330                 335     


Glu Asp Phe Ser Ser Ile Ala Asp Met Asp Phe Ser Ala Leu Leu Gly 
            340                 345                 350         


Ser Gly Ser Gly Ser Arg Asp Ser Arg Glu Gly Met Phe Leu Pro Lys 
        355                 360                 365             


Pro Glu Ala Gly Ser Ala Ile Ser Asp Val Phe Glu Gly Arg Glu Val 
    370                 375                 380                 


Cys Gln Pro Lys Arg Ile Arg Pro Phe His Pro Pro Gly Ser Pro Trp 
385                 390                 395                 400 


Ala Asn Arg Pro Leu Pro Ala Ser Leu Ala Pro Thr Pro Thr Gly Pro 
                405                 410                 415     


Val His Glu Pro Val Gly Ser Leu Thr Pro Ala Pro Val Pro Gln Pro 
            420                 425                 430         


Leu Asp Pro Ala Pro Ala Val Thr Pro Glu Ala Ser His Leu Leu Glu 
        435                 440                 445             


Asp Pro Asp Glu Glu Thr Ser Gln Ala Val Lys Ala Leu Arg Glu Met 
    450                 455                 460                 


Ala Asp Thr Val Ile Pro Gln Lys Glu Glu Ala Ala Ile Cys Gly Gln 
465                 470                 475                 480 


Met Asp Leu Ser His Pro Pro Pro Arg Gly His Leu Asp Glu Leu Thr 
                485                 490                 495     


Thr Thr Leu Glu Ser Met Thr Glu Asp Leu Asn Leu Asp Ser Pro Leu 
            500                 505                 510         


Thr Pro Glu Leu Asn Glu Ile Leu Asp Thr Phe Leu Asn Asp Glu Cys 
        515                 520                 525             


Leu Leu His Ala Met His Ile Ser Thr Gly Leu Ser Ile Phe Asp Thr 
    530                 535                 540                 


Ser Leu Phe Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr 
545                 550                 555                 560 


Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser 
                565                 570                 575     


Gly Gly Ser Met Lys Asn Asn Asp Val Pro Phe Tyr Asn Gly Asn Glu 
            580                 585                 590         


Asp Thr Phe Val Lys Ser Ala Gln Leu Gln Met Pro Gly Lys Tyr Phe 
        595                 600                 605             


Arg Pro Gly Ser Tyr Ser Pro Gln Gly Thr Asp Leu Met Tyr Lys Gly 
    610                 615                 620                 


Asp Ile His Tyr Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn 
625                 630                 635                 640 


Pro Lys Glu Asn Leu Val Gln Gly Asn Asp Ser Ser Glu Pro Tyr Ile 
                645                 650                 655     


Arg Ile Ser Asn Glu Gly Tyr Phe Asn Ser Ser Val Pro Val Gly Asp 
            660                 665                 670         


Arg Met Val Thr Glu Ile Glu Arg Val Thr Glu Pro Ile Ile Ser Asn 
        675                 680                 685             


Lys Tyr Trp Gly Asn Pro Glu Phe Val Leu Gly Asn Ile Lys Glu His 
    690                 695                 700                 


Ile Ile Arg Asn Asp Lys Thr Asn Glu Met Tyr Gly Gln Phe Tyr Trp 
705                 710                 715                 720 


Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala 
                725                 730                 735     


Val Asp Asn Val Asn Asn Tyr Asn Leu Trp Tyr Val Arg Thr Ser Lys 
            740                 745                 750         


Pro Glu Leu Lys Glu Phe Lys Ala Ser Ser Gly Lys Lys Asp Asp Pro 
        755                 760                 765             


Val Lys Phe Ile Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly 
    770                 775                 780                 


Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ser 
785                 790                 795                 800 


Glu Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile Ile Lys 
                805                 810                 815     


Asn Gly Glu Thr Val His His Gln Gly Asn Tyr Leu Arg Ser Asn Pro 
            820                 825                 830         


Gln Lys Asn Asn Asp Lys Pro Asn Glu Gly Asp Ala Gly Tyr Phe Ser 
        835                 840                 845             


Lys Glu Gly Ile Pro Phe Tyr Pro Gln Glu Cys Gly Arg Tyr Thr Ala 
    850                 855                 860                 


Lys Leu Lys Leu Ile Asp Ala Val Gln Arg Glu Ser Thr Glu Lys Val 
865                 870                 875                 880 


Val Asp Phe Val Val Asp Gly Ser Cys Gly Thr Gln Val Pro Pro Thr 
                885                 890                 895     


Thr Asp Pro Val Asp Gly Glu Phe Asn Tyr Lys Ile Asp Tyr Ser Ala 
            900                 905                 910         


Asp Arg Ile Glu Gly Glu Thr Ala Arg Lys Asp Lys Glu Ile Lys Thr 
        915                 920                 925             


Arg Val Asp Val Ser Arg Ala Ser Phe Lys Glu Glu His Asp Gln Tyr 
    930                 935                 940                 


Arg Ala Lys Leu Asp Glu Glu Phe Lys Lys Tyr Gln Lys Glu Val Asp 
945                 950                 955                 960 


Ala Tyr Ile Ser Glu Arg Asp Ser Ala Gln Asp Ser Leu Asn Tyr Cys 
                965                 970                 975     


Arg Arg Asn Pro Ile Arg Glu Glu Asp Glu Lys Gly Gly Val His Tyr 
            980                 985                 990         


Arg Asp Arg Asp Cys Ser Trp Glu  Glu Asn Asn Leu Asp  Asn Val Val 
        995                 1000                 1005             


Ser Lys  Leu Glu Lys Ala Lys  Gln Asn Arg Glu Lys  Leu Ser Lys 
    1010                 1015                 1020             


Lys Leu  Gly Asp Phe Asp Lys  Leu Asn Ala Gln Tyr  His Asn Pro 
    1025                 1030                 1035             


Glu Val  Thr Val Ile Leu Lys  His Asn Gly Lys Lys  Val Glu Ser 
    1040                 1045                 1050             


Lys Thr  Val Arg Leu Lys Glu  Gly Glu Lys Lys Thr  Val Phe Phe 
    1055                 1060                 1065             


Asn Trp  Glu His Lys Gly Lys  Gly Thr Ile Gln Ala  Glu Ile Asn 
    1070                 1075                 1080             


Pro Ala  Asp Glu Asp Gly Ser  Arg Leu Asp Ile Lys  Glu Thr Thr 
    1085                 1090                 1095             


Tyr Lys  Asn Asn Pro Ile Lys  Thr Ala Ile Tyr Glu  Pro Ser Gln 
    1100                 1105                 1110             


Glu Lys  Ala Met Cys Gly Ala  Thr Ser Val Lys Gly  Val Val Glu 
    1115                 1120                 1125             


Thr Val  Ser Asn Arg Val Ser  Val Glu Asp Thr Val  Gly Glu Met 
    1130                 1135                 1140             


Tyr His  Glu Thr Leu Thr Gly  Ser Ile Asp Lys Leu  Val Pro Ser 
    1145                 1150                 1155             


Lys Leu  His Ser Gly Tyr Gly  Phe Thr Tyr Glu Leu  Asp Gly Lys 
    1160                 1165                 1170             


Tyr Thr  Asn Asn Trp Asp Gln  Asn Tyr Gln Gly Val  Phe Thr Val 
    1175                 1180                 1185             


Ala Thr  Ala Lys Tyr Pro Phe  Ala Asp Glu Gly Leu  Lys Leu Asn 
    1190                 1195                 1200             


Gln Asp  Leu Glu Lys Lys Glu  Ile Lys Asp Asn Thr  Ser Lys Phe 
    1205                 1210                 1215             


Ile Pro  Lys Asn Met Tyr Leu  Ser Glu Lys Thr Gly  Tyr Val Phe 
    1220                 1225                 1230             


Asp Ser  Lys Arg Pro Ile Lys  Ser Leu Tyr Trp Asp  Gly Gln Glu 
    1235                 1240                 1245             


Lys Ile  Ile Asp Gly Gly His  Lys Trp Tyr Ala Pro  Met Lys Thr 
    1250                 1255                 1260             


Lys Asp  Gly Lys Tyr Ser Phe  Lys Val Glu Thr Lys  Pro Thr Gly 
    1265                 1270                 1275             


Ile Asn  Glu Met Ser Leu Cys  Met Thr Glu Glu Val  Glu Ile Lys 
    1280                 1285                 1290             


Gly Val  Ala Tyr Asp Asp Phe  Ile Lys Arg Arg Val  Phe Pro Asp 
    1295                 1300                 1305             


Asp Pro  Phe Pro Gly Gly Ser  Gly Val Gly Trp Asn  Trp Val Gly 
    1310                 1315                 1320             


Lys Glu  Glu Leu Leu His Lys  Leu Thr Asp Trp Tyr  Tyr Met Lys 
    1325                 1330                 1335             


Asn Gly  Asn Lys Asn Lys Ile  Lys Arg Pro Ala Ala  Thr Lys Lys 
    1340                 1345                 1350             


Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1355                 1360     


<210> 62
<211> 199
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 62
Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His 
1               5                   10                  15      


Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr 
            20                  25                  30          


Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met 
        35                  40                  45              


Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys 
    50                  55                  60                  


Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro 
65                  70                  75                  80  


Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile 
                85                  90                  95      


Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala 
            100                 105                 110         


Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg 
        115                 120                 125             


Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg 
    130                 135                 140                 


Asp Ala Gly Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His 
145                 150                 155                 160 


Cys Trp Asp Thr Phe Val Asp His Gln Gly Cys Pro Phe Gln Pro Trp 
                165                 170                 175     


Asp Gly Leu Asp Glu His Ser Gln Ala Leu Ser Gly Arg Leu Arg Ala 
            180                 185                 190         


Ile Leu Gln Asn Gln Gly Asn 
        195                 


<210> 63
<211> 415
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 63
Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys 
1               5                   10                  15      


Lys Lys Ser Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala 
            20                  25                  30          


Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly 
        35                  40                  45              


Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg 
    50                  55                  60                  


Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu 
65                  70                  75                  80  


Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr 
                85                  90                  95      


Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile 
            100                 105                 110         


His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr 
        115                 120                 125             


Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn 
    130                 135                 140                 


His Arg Val Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala 
145                 150                 155                 160 


Leu Leu Ser Asp Phe Phe Arg Met Arg Arg Gln Glu Ile Lys Ala Gln 
                165                 170                 175     


Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly Gly Ser Ser Gly Gly Ser 
            180                 185                 190         


Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 
        195                 200                 205             


Ser Gly Gly Ser Ser Gly Gly Ser Ser Glu Val Glu Phe Ser His Glu 
    210                 215                 220                 


Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Arg Asp Glu 
225                 230                 235                 240 


Arg Glu Val Pro Val Gly Ala Val Leu Val Leu Asn Asn Arg Val Ile 
                245                 250                 255     


Gly Glu Gly Trp Asn Arg Ala Ile Gly Leu His Asp Pro Thr Ala His 
            260                 265                 270         


Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr 
        275                 280                 285             


Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Phe Glu Pro Cys Val Met 
    290                 295                 300                 


Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly 
305                 310                 315                 320 


Val Arg Asn Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu 
                325                 330                 335     


His Tyr Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu 
            340                 345                 350         


Ala Asp Glu Cys Ala Ala Leu Leu Cys Tyr Phe Phe Arg Met Pro Arg 
        355                 360                 365             


Gln Val Phe Asn Ala Gln Lys Lys Ala Gln Ser Ser Thr Asp Ser Gly 
    370                 375                 380                 


Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 
385                 390                 395                 400 


Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Ser 
                405                 410                 415 


<210> 64
<211> 1276
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Leu Lys Arg Gly Leu Leu Val Leu Cys Thr Ser Thr Ala Leu Ile 
        35                  40                  45              


Tyr Pro Ser Ile Val Asn Ala Lys Asn Asn Asp Val Pro Phe Tyr Asp 
    50                  55                  60                  


Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly 
65                  70                  75                  80  


Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr 
                85                  90                  95      


Arg Ala Asp Ile His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp 
            100                 105                 110         


Gly Asn Pro Lys Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu Pro 
        115                 120                 125             


Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala 
    130                 135                 140                 


Gly Asp Arg Met Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val Ile 
145                 150                 155                 160 


Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile Asp 
                165                 170                 175     


Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe 
            180                 185                 190         


Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala 
        195                 200                 205             


Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr 
    210                 215                 220                 


Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp 
225                 230                 235                 240 


Val Pro Val Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn 
                245                 250                 255     


Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr 
            260                 265                 270         


Gln Ala Ala Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile 
        275                 280                 285             


Thr Lys Asp Gly Glu Thr Val His His Gln Glu Asn Tyr Leu Arg Ser 
    290                 295                 300                 


Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys 
305                 310                 315                 320 


Phe Val Lys Asp Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr 
                325                 330                 335     


Thr Ala Lys Ile Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn Glu 
            340                 345                 350         


Lys Asn Val Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val Thr 
        355                 360                 365             


Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp 
    370                 375                 380                 


Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn 
385                 390                 395                 400 


Ile Lys Thr Arg Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu Arg 
                405                 410                 415     


Asp Gln Tyr Arg Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln Gln 
            420                 425                 430         


Glu Val Asn Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu 
        435                 440                 445             


Ser Tyr Cys Arg Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly Lys 
    450                 455                 460                 


Asp His Tyr Tyr Asp Arg Asp Cys Ser Trp Glu Glu Asn Lys Leu Asp 
465                 470                 475                 480 


Ser Ala Ala Ser Lys Leu Asp Asn Ala Arg Gln Lys Phe Glu Lys Glu 
                485                 490                 495     


Lys Asn Lys Leu Lys Lys Leu Asp Val Leu Glu Glu Lys Tyr Thr Asn 
            500                 505                 510         


Pro Glu Thr Val Val Val Leu Lys His Asn Gly Gln Gln Val Ala Leu 
        515                 520                 525             


Gln Lys Val Arg Leu Thr Glu Gly Glu Lys Lys Thr Leu Asn Leu Asp 
    530                 535                 540                 


Trp Gln His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala 
545                 550                 555                 560 


Gly Asn Arg Ile Asp Ile Glu Glu Thr Thr Tyr Lys Asn Asn Pro Ile 
                565                 570                 575     


Lys Thr Ala Ile Tyr Glu Pro Ser Lys Glu Lys Ala Met Cys Gly Val 
            580                 585                 590         


Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Glu Arg Val Ser Lys 
        595                 600                 605             


Glu Asp Ile Thr Gly Glu Met Tyr Tyr Glu Thr Leu Thr Gly Ser Ile 
    610                 615                 620                 


Asp Asn Leu Ala Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Ser Tyr 
625                 630                 635                 640 


Glu Val Asn Gly Lys Tyr Lys Asn Asp Trp Asn Ala Asn Tyr Pro Gly 
                645                 650                 655     


Val Phe Thr Ala Ala Lys Ala Gln Tyr Pro Phe Ala Asp Glu Gly Leu 
            660                 665                 670         


Lys Ser Thr Gln Asp Leu Glu Lys Lys Glu Leu Lys Asp Asn Thr Ala 
        675                 680                 685             


Lys Phe Leu Pro Lys Asn Met Tyr Leu Ser Glu Ala Thr Gly His Val 
    690                 695                 700                 


Phe Asp Ser Lys Arg Pro Thr Lys Ser Leu Tyr Trp Asp Gly Gln Glu 
705                 710                 715                 720 


Lys Ile Ile Asp Gly Gly Gln Lys Trp Tyr Ser Pro Leu Lys Thr Lys 
                725                 730                 735     


Asp Gly Val Tyr Thr Phe Asn Val Glu Thr Ala Pro Ala Gly Ile Asn 
            740                 745                 750         


Glu Met Ser Leu Cys Leu Thr Glu Gln Val Glu Ile Lys Gly Val Ala 
        755                 760                 765             


Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro 
    770                 775                 780                 


Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu 
785                 790                 795                 800 


His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Thr Gly Lys Ser Gly Gly 
                805                 810                 815     


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            820                 825                 830         


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ala Lys 
        835                 840                 845             


Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Ser 
    850                 855                 860                 


Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu 
865                 870                 875                 880 


Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu 
                885                 890                 895     


Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly 
            900                 905                 910         


Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly 
        915                 920                 925             


Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val 
    930                 935                 940                 


Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg 
945                 950                 955                 960 


Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala 
                965                 970                 975     


Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg Val 
            980                 985                 990         


Glu Ile Thr Glu Gly Ile Leu Ala  Asp Glu Cys Ala Ala  Leu Leu Ser 
        995                 1000                 1005             


Asp Phe  Phe Arg Met Arg Arg  Gln Glu Ile Lys Ala  Gln Lys Lys 
    1010                 1015                 1020             


Ala Gln  Ser Ser Thr Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser 
    1025                 1030                 1035             


Gly Ser  Glu Thr Pro Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser 
    1040                 1045                 1050             


Ser Gly  Gly Ser Ser Gly Gly  Ser Ser Glu Val Glu  Phe Ser His 
    1055                 1060                 1065             


Glu Tyr  Trp Met Arg His Ala  Leu Thr Leu Ala Lys  Arg Ala Arg 
    1070                 1075                 1080             


Asp Glu  Arg Glu Val Pro Val  Gly Ala Val Leu Val  Leu Asn Asn 
    1085                 1090                 1095             


Arg Val  Ile Gly Glu Gly Trp  Asn Arg Ala Ile Gly  Leu His Asp 
    1100                 1105                 1110             


Pro Thr  Ala His Ala Glu Ile  Met Ala Leu Arg Gln  Gly Gly Leu 
    1115                 1120                 1125             


Val Met  Gln Asn Tyr Arg Leu  Ile Asp Ala Thr Leu  Tyr Val Thr 
    1130                 1135                 1140             


Phe Glu  Pro Cys Val Met Cys  Ala Gly Ala Met Ile  His Ser Arg 
    1145                 1150                 1155             


Ile Gly  Arg Val Val Phe Gly  Val Arg Asn Ala Lys  Thr Gly Ala 
    1160                 1165                 1170             


Ala Gly  Ser Leu Met Asp Val  Leu His Tyr Pro Gly  Met Asn His 
    1175                 1180                 1185             


Arg Val  Glu Ile Thr Glu Gly  Ile Leu Ala Asp Glu  Cys Ala Ala 
    1190                 1195                 1200             


Leu Leu  Cys Tyr Phe Phe Arg  Met Pro Arg Gln Val  Phe Asn Ala 
    1205                 1210                 1215             


Gln Lys  Lys Ala Gln Ser Ser  Thr Asp Ser Gly Gly  Ser Ser Gly 
    1220                 1225                 1230             


Gly Ser  Ser Gly Ser Glu Thr  Pro Gly Thr Ser Glu  Ser Ala Thr 
    1235                 1240                 1245             


Pro Glu  Ser Ser Gly Gly Ser  Ser Gly Gly Ser Ser  Lys Arg Pro 
    1250                 1255                 1260             


Ala Ala  Thr Lys Lys Ala Gly  Gln Ala Lys Lys Lys  Lys 
    1265                 1270                 1275     


<210> 65
<211> 1253
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 65
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn Asp Thr Phe Leu 
        35                  40                  45              


Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe Arg Pro Gly Ser 
    50                  55                  60                  


Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp Ile His Phe Pro 
65                  70                  75                  80  


Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu 
                85                  90                  95      


Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ala Asn Glu 
            100                 105                 110         


Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg Met Val Thr Glu 
        115                 120                 125             


Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys Tyr Trp Gly Asn 
    130                 135                 140                 


Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser Ile Asn Thr Tyr 
145                 150                 155                 160 


Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala 
                165                 170                 175     


Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Glu Gly Ile Asn 
            180                 185                 190         


Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro Glu Leu Lys Asp 
        195                 200                 205             


Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val Lys Phe Thr Phe 
    210                 215                 220                 


Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp 
225                 230                 235                 240 


Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala Ala Gly Glu Arg 
                245                 250                 255     


Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp Gly Glu Thr Val 
            260                 265                 270         


His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln Lys Asp Asn Glu 
        275                 280                 285             


Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys Asp Asp Val Lys 
    290                 295                 300                 


Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys Ile Lys Val Leu 
305                 310                 315                 320 


Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val Asp Phe Thr Ile 
                325                 330                 335     


Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro Asp Pro Gly Asp 
            340                 345                 350         


Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala Asp Arg Ile Glu 
        355                 360                 365             


Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr Arg Val Asp Val 
    370                 375                 380                 


Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr Arg Val Lys Val 
385                 390                 395                 400 


Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn Ser Ser Glu Ser 
                405                 410                 415     


Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys Arg Arg Asn Pro 
            420                 425                 430         


Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr Tyr Asp Arg Asp 
        435                 440                 445             


Cys Ser Trp Glu Glu Asn Lys Leu Asp Ser Ala Ala Ser Lys Leu Asp 
    450                 455                 460                 


Asn Ala Arg Gln Lys Phe Glu Lys Glu Lys Asn Lys Leu Lys Lys Leu 
465                 470                 475                 480 


Asp Val Leu Glu Glu Lys Tyr Thr Asn Pro Glu Thr Val Val Val Leu 
                485                 490                 495     


Lys His Asn Gly Gln Gln Val Ala Leu Gln Lys Val Arg Leu Thr Glu 
            500                 505                 510         


Gly Glu Lys Lys Thr Leu Asn Leu Asp Trp Gln His Lys Gly Lys Gly 
        515                 520                 525             


Thr Ile Gln Ala Glu Ile Asn Pro Ala Gly Asn Arg Ile Asp Ile Glu 
    530                 535                 540                 


Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro 
545                 550                 555                 560 


Ser Lys Glu Lys Ala Met Cys Gly Val Thr Ser Val Lys Gly Val Val 
                565                 570                 575     


Glu Thr Val Ser Glu Arg Val Ser Lys Glu Asp Ile Thr Gly Glu Met 
            580                 585                 590         


Tyr Tyr Glu Thr Leu Thr Gly Ser Ile Asp Asn Leu Ala Pro Ser Lys 
        595                 600                 605             


Leu His Ser Gly Tyr Gly Phe Ser Tyr Glu Val Asn Gly Lys Tyr Lys 
    610                 615                 620                 


Asn Asp Trp Asn Ala Asn Tyr Pro Gly Val Phe Thr Ala Ala Lys Ala 
625                 630                 635                 640 


Gln Tyr Pro Phe Ala Asp Glu Gly Leu Lys Ser Thr Gln Asp Leu Glu 
                645                 650                 655     


Lys Lys Glu Leu Lys Asp Asn Thr Ala Lys Phe Leu Pro Lys Asn Met 
            660                 665                 670         


Tyr Leu Ser Glu Ala Thr Gly His Val Phe Asp Ser Lys Arg Pro Thr 
        675                 680                 685             


Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp Gly Gly Gln 
    690                 695                 700                 


Lys Trp Tyr Ser Pro Leu Lys Thr Lys Asp Gly Val Tyr Thr Phe Asn 
705                 710                 715                 720 


Val Glu Thr Ala Pro Ala Gly Ile Asn Glu Met Ser Leu Cys Leu Thr 
                725                 730                 735     


Glu Gln Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg 
            740                 745                 750         


Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly Val Gly Trp 
        755                 760                 765             


Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr Asp Trp Tyr 
    770                 775                 780                 


Tyr Met Lys Thr Gly Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
785                 790                 795                 800 


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly 
                805                 810                 815     


Gly Ser Ser Gly Gly Ser Met Ala Lys Arg Pro Ala Ala Thr Lys Lys 
            820                 825                 830         


Ala Gly Gln Ala Lys Lys Lys Lys Ser Glu Val Glu Phe Ser His Glu 
        835                 840                 845             


Tyr Trp Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu 
    850                 855                 860                 


Arg Glu Val Pro Val Gly Ala Val Leu Val His Asn Asn Arg Val Ile 
865                 870                 875                 880 


Gly Glu Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro Thr Ala His 
                885                 890                 895     


Ala Glu Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr 
            900                 905                 910         


Arg Leu Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met 
        915                 920                 925             


Cys Ala Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly 
    930                 935                 940                 


Ala Arg Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu 
945                 950                 955                 960 


His His Pro Gly Met Asn His Arg Val Glu Ile Thr Glu Gly Ile Leu 
                965                 970                 975     


Ala Asp Glu Cys Ala Ala Leu Leu Ser Asp Phe Phe Arg Met Arg Arg 
            980                 985                 990         


Gln Glu Ile Lys Ala Gln Lys Lys  Ala Gln Ser Ser Thr  Asp Ser Gly 
        995                 1000                 1005             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1010                 1015                 1020             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1025                 1030                 1035             


Ser Glu  Val Glu Phe Ser His  Glu Tyr Trp Met Arg  His Ala Leu 
    1040                 1045                 1050             


Thr Leu  Ala Lys Arg Ala Arg  Asp Glu Arg Glu Val  Pro Val Gly 
    1055                 1060                 1065             


Ala Val  Leu Val Leu Asn Asn  Arg Val Ile Gly Glu  Gly Trp Asn 
    1070                 1075                 1080             


Arg Ala  Ile Gly Leu His Asp  Pro Thr Ala His Ala  Glu Ile Met 
    1085                 1090                 1095             


Ala Leu  Arg Gln Gly Gly Leu  Val Met Gln Asn Tyr  Arg Leu Ile 
    1100                 1105                 1110             


Asp Ala  Thr Leu Tyr Val Thr  Phe Glu Pro Cys Val  Met Cys Ala 
    1115                 1120                 1125             


Gly Ala  Met Ile His Ser Arg  Ile Gly Arg Val Val  Phe Gly Val 
    1130                 1135                 1140             


Arg Asn  Ala Lys Thr Gly Ala  Ala Gly Ser Leu Met  Asp Val Leu 
    1145                 1150                 1155             


His Tyr  Pro Gly Met Asn His  Arg Val Glu Ile Thr  Glu Gly Ile 
    1160                 1165                 1170             


Leu Ala  Asp Glu Cys Ala Ala  Leu Leu Cys Tyr Phe  Phe Arg Met 
    1175                 1180                 1185             


Pro Arg  Gln Val Phe Asn Ala  Gln Lys Lys Ala Gln  Ser Ser Thr 
    1190                 1195                 1200             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1205                 1210                 1215             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1220                 1225                 1230             


Gly Gly  Ser Ser Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1235                 1240                 1245             


Ala Lys  Lys Lys Lys 
    1250             


<210> 66
<211> 1283
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Phe Lys Lys Gly Ile Phe Val Leu Phe Thr Ser Val Leu Leu Ser 
        35                  40                  45              


Ala Pro Asn Ser Ala Asp Ala Lys Asn Asn Asp Val Pro Phe Tyr Asn 
    50                  55                  60                  


Gly Asn Glu Asp Thr Phe Val Lys Ser Ala Gln Leu Gln Met Pro Gly 
65                  70                  75                  80  


Lys Tyr Phe Arg Pro Gly Ser Tyr Ser Pro Gln Gly Thr Asp Leu Met 
                85                  90                  95      


Tyr Lys Gly Asp Ile His Tyr Pro Ala Val Tyr Asn Gly Ser Phe Asn 
            100                 105                 110         


Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Gly Asn Asp Ser Ser Glu 
        115                 120                 125             


Pro Tyr Ile Arg Ile Ser Asn Glu Gly Tyr Phe Asn Ser Ser Val Pro 
    130                 135                 140                 


Val Gly Asp Arg Met Val Thr Glu Ile Glu Arg Val Thr Glu Pro Ile 
145                 150                 155                 160 


Ile Ser Asn Lys Tyr Trp Gly Asn Pro Glu Phe Val Leu Gly Asn Ile 
                165                 170                 175     


Lys Glu His Ile Ile Arg Asn Asp Lys Thr Asn Glu Met Tyr Gly Gln 
            180                 185                 190         


Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly 
        195                 200                 205             


Ala Gly Ala Val Asp Asn Val Asn Asn Tyr Asn Leu Trp Tyr Val Arg 
    210                 215                 220                 


Thr Ser Lys Pro Glu Leu Lys Glu Phe Lys Ala Ser Ser Gly Lys Lys 
225                 230                 235                 240 


Asp Asp Pro Val Lys Phe Ile Phe Asn Gly Phe Glu Tyr Val Ser Lys 
                245                 250                 255     


Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro 
            260                 265                 270         


Tyr Gln Ser Glu Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp 
        275                 280                 285             


Ile Ile Lys Asn Gly Glu Thr Val His His Gln Gly Asn Tyr Leu Arg 
    290                 295                 300                 


Ser Asn Pro Gln Lys Asn Asn Asp Lys Pro Asn Glu Gly Asp Ala Gly 
305                 310                 315                 320 


Tyr Phe Ser Lys Glu Gly Ile Pro Phe Tyr Pro Gln Glu Cys Gly Arg 
                325                 330                 335     


Tyr Thr Ala Lys Leu Lys Leu Ile Asp Ala Val Gln Arg Glu Ser Thr 
            340                 345                 350         


Glu Lys Val Val Asp Phe Val Val Asp Gly Ser Cys Gly Thr Gln Val 
        355                 360                 365             


Pro Pro Thr Thr Asp Pro Val Asp Gly Glu Phe Asn Tyr Lys Ile Asp 
    370                 375                 380                 


Tyr Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Lys Asp Lys Glu 
385                 390                 395                 400 


Ile Lys Thr Arg Val Asp Val Ser Arg Ala Ser Phe Lys Glu Glu His 
                405                 410                 415     


Asp Gln Tyr Arg Ala Lys Leu Asp Glu Glu Phe Lys Lys Tyr Gln Lys 
            420                 425                 430         


Glu Val Asp Ala Tyr Ile Ser Glu Arg Asp Ser Ala Gln Asp Ser Leu 
        435                 440                 445             


Asn Tyr Cys Arg Arg Asn Pro Ile Arg Glu Glu Asp Glu Lys Gly Gly 
    450                 455                 460                 


Val His Tyr Arg Asp Arg Asp Cys Ser Trp Glu Glu Asn Asn Leu Asp 
465                 470                 475                 480 


Asn Val Val Ser Lys Leu Glu Lys Ala Lys Gln Asn Arg Glu Lys Leu 
                485                 490                 495     


Ser Lys Lys Leu Gly Asp Phe Asp Lys Leu Asn Ala Gln Tyr His Asn 
            500                 505                 510         


Pro Glu Val Thr Val Ile Leu Lys His Asn Gly Lys Lys Val Glu Ser 
        515                 520                 525             


Lys Thr Val Arg Leu Lys Glu Gly Glu Lys Lys Thr Val Phe Phe Asn 
    530                 535                 540                 


Trp Glu His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala 
545                 550                 555                 560 


Asp Glu Asp Gly Ser Arg Leu Asp Ile Lys Glu Thr Thr Tyr Lys Asn 
                565                 570                 575     


Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro Ser Gln Glu Lys Ala Met 
            580                 585                 590         


Cys Gly Ala Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Asn Arg 
        595                 600                 605             


Val Ser Val Glu Asp Thr Val Gly Glu Met Tyr His Glu Thr Leu Thr 
    610                 615                 620                 


Gly Ser Ile Asp Lys Leu Val Pro Ser Lys Leu His Ser Gly Tyr Gly 
625                 630                 635                 640 


Phe Thr Tyr Glu Leu Asp Gly Lys Tyr Thr Asn Asn Trp Asp Gln Asn 
                645                 650                 655     


Tyr Gln Gly Val Phe Thr Val Ala Thr Ala Lys Tyr Pro Phe Ala Asp 
            660                 665                 670         


Glu Gly Leu Lys Leu Asn Gln Asp Leu Glu Lys Lys Glu Ile Lys Asp 
        675                 680                 685             


Asn Thr Ser Lys Phe Ile Pro Lys Asn Met Tyr Leu Ser Glu Lys Thr 
    690                 695                 700                 


Gly Tyr Val Phe Asp Ser Lys Arg Pro Ile Lys Ser Leu Tyr Trp Asp 
705                 710                 715                 720 


Gly Gln Glu Lys Ile Ile Asp Gly Gly His Lys Trp Tyr Ala Pro Met 
                725                 730                 735     


Lys Thr Lys Asp Gly Lys Tyr Ser Phe Lys Val Glu Thr Lys Pro Thr 
            740                 745                 750         


Gly Ile Asn Glu Met Ser Leu Cys Met Thr Glu Glu Val Glu Ile Lys 
        755                 760                 765             


Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp 
    770                 775                 780                 


Pro Phe Pro Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu 
785                 790                 795                 800 


Glu Leu Leu His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Asn Gly Asn 
                805                 810                 815     


Lys Asn Lys Ile Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
            820                 825                 830         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
        835                 840                 845             


Ser Gly Gly Ser Met Ala Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly 
    850                 855                 860                 


Gln Ala Lys Lys Lys Lys Ser Glu Val Glu Phe Ser His Glu Tyr Trp 
865                 870                 875                 880 


Met Arg His Ala Leu Thr Leu Ala Lys Arg Ala Trp Asp Glu Arg Glu 
                885                 890                 895     


Val Pro Val Gly Ala Val Leu Val His Asn Asn Arg Val Ile Gly Glu 
            900                 905                 910         


Gly Trp Asn Arg Pro Ile Gly Arg His Asp Pro Thr Ala His Ala Glu 
        915                 920                 925             


Ile Met Ala Leu Arg Gln Gly Gly Leu Val Met Gln Asn Tyr Arg Leu 
    930                 935                 940                 


Ile Asp Ala Thr Leu Tyr Val Thr Leu Glu Pro Cys Val Met Cys Ala 
945                 950                 955                 960 


Gly Ala Met Ile His Ser Arg Ile Gly Arg Val Val Phe Gly Ala Arg 
                965                 970                 975     


Asp Ala Lys Thr Gly Ala Ala Gly Ser Leu Met Asp Val Leu His His 
            980                 985                 990         


Pro Gly Met Asn His Arg Val Glu  Ile Thr Glu Gly Ile  Leu Ala Asp 
        995                 1000                 1005             


Glu Cys  Ala Ala Leu Leu Ser  Asp Phe Phe Arg Met  Arg Arg Gln 
    1010                 1015                 1020             


Glu Ile  Lys Ala Gln Lys Lys  Ala Gln Ser Ser Thr  Asp Ser Gly 
    1025                 1030                 1035             


Gly Ser  Ser Gly Gly Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser 
    1040                 1045                 1050             


Glu Ser  Ala Thr Pro Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser 
    1055                 1060                 1065             


Ser Glu  Val Glu Phe Ser His  Glu Tyr Trp Met Arg  His Ala Leu 
    1070                 1075                 1080             


Thr Leu  Ala Lys Arg Ala Arg  Asp Glu Arg Glu Val  Pro Val Gly 
    1085                 1090                 1095             


Ala Val  Leu Val Leu Asn Asn  Arg Val Ile Gly Glu  Gly Trp Asn 
    1100                 1105                 1110             


Arg Ala  Ile Gly Leu His Asp  Pro Thr Ala His Ala  Glu Ile Met 
    1115                 1120                 1125             


Ala Leu  Arg Gln Gly Gly Leu  Val Met Gln Asn Tyr  Arg Leu Ile 
    1130                 1135                 1140             


Asp Ala  Thr Leu Tyr Val Thr  Phe Glu Pro Cys Val  Met Cys Ala 
    1145                 1150                 1155             


Gly Ala  Met Ile His Ser Arg  Ile Gly Arg Val Val  Phe Gly Val 
    1160                 1165                 1170             


Arg Asn  Ala Lys Thr Gly Ala  Ala Gly Ser Leu Met  Asp Val Leu 
    1175                 1180                 1185             


His Tyr  Pro Gly Met Asn His  Arg Val Glu Ile Thr  Glu Gly Ile 
    1190                 1195                 1200             


Leu Ala  Asp Glu Cys Ala Ala  Leu Leu Cys Tyr Phe  Phe Arg Met 
    1205                 1210                 1215             


Pro Arg  Gln Val Phe Asn Ala  Gln Lys Lys Ala Gln  Ser Ser Thr 
    1220                 1225                 1230             


Asp Ser  Gly Gly Ser Ser Gly  Gly Ser Ser Gly Ser  Glu Thr Pro 
    1235                 1240                 1245             


Gly Thr  Ser Glu Ser Ala Thr  Pro Glu Ser Ser Gly  Gly Ser Ser 
    1250                 1255                 1260             


Gly Gly  Ser Ser Lys Arg Pro  Ala Ala Thr Lys Lys  Ala Gly Gln 
    1265                 1270                 1275             


Ala Lys  Lys Lys Lys 
    1280             


<210> 67
<211> 1260
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Asn Asn Asp Val Pro Phe Tyr Asn Gly Asn Glu Asp Thr Phe Val 
        35                  40                  45              


Lys Ser Ala Gln Leu Gln Met Pro Gly Lys Tyr Phe Arg Pro Gly Ser 
    50                  55                  60                  


Tyr Ser Pro Gln Gly Thr Asp Leu Met Tyr Lys Gly Asp Ile His Tyr 
65                  70                  75                  80  


Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn 
                85                  90                  95      


Leu Val Gln Gly Asn Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ser Asn 
            100                 105                 110         


Glu Gly Tyr Phe Asn Ser Ser Val Pro Val Gly Asp Arg Met Val Thr 
        115                 120                 125             


Glu Ile Glu Arg Val Thr Glu Pro Ile Ile Ser Asn Lys Tyr Trp Gly 
    130                 135                 140                 


Asn Pro Glu Phe Val Leu Gly Asn Ile Lys Glu His Ile Ile Arg Asn 
145                 150                 155                 160 


Asp Lys Thr Asn Glu Met Tyr Gly Gln Phe Tyr Trp Ile Arg Asp Ile 
                165                 170                 175     


Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Asp Asn Val 
            180                 185                 190         


Asn Asn Tyr Asn Leu Trp Tyr Val Arg Thr Ser Lys Pro Glu Leu Lys 
        195                 200                 205             


Glu Phe Lys Ala Ser Ser Gly Lys Lys Asp Asp Pro Val Lys Phe Ile 
    210                 215                 220                 


Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg 
225                 230                 235                 240 


Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ser Glu Ala Gly Glu 
                245                 250                 255     


Arg Asn Arg Val Lys Trp Met Leu Asp Ile Ile Lys Asn Gly Glu Thr 
            260                 265                 270         


Val His His Gln Gly Asn Tyr Leu Arg Ser Asn Pro Gln Lys Asn Asn 
        275                 280                 285             


Asp Lys Pro Asn Glu Gly Asp Ala Gly Tyr Phe Ser Lys Glu Gly Ile 
    290                 295                 300                 


Pro Phe Tyr Pro Gln Glu Cys Gly Arg Tyr Thr Ala Lys Leu Lys Leu 
305                 310                 315                 320 


Ile Asp Ala Val Gln Arg Glu Ser Thr Glu Lys Val Val Asp Phe Val 
                325                 330                 335     


Val Asp Gly Ser Cys Gly Thr Gln Val Pro Pro Thr Thr Asp Pro Val 
            340                 345                 350         


Asp Gly Glu Phe Asn Tyr Lys Ile Asp Tyr Ser Ala Asp Arg Ile Glu 
        355                 360                 365             


Gly Glu Thr Ala Arg Lys Asp Lys Glu Ile Lys Thr Arg Val Asp Val 
    370                 375                 380                 


Ser Arg Ala Ser Phe Lys Glu Glu His Asp Gln Tyr Arg Ala Lys Leu 
385                 390                 395                 400 


Asp Glu Glu Phe Lys Lys Tyr Gln Lys Glu Val Asp Ala Tyr Ile Ser 
                405                 410                 415     


Glu Arg Asp Ser Ala Gln Asp Ser Leu Asn Tyr Cys Arg Arg Asn Pro 
            420                 425                 430         


Ile Arg Glu Glu Asp Glu Lys Gly Gly Val His Tyr Arg Asp Arg Asp 
        435                 440                 445             


Cys Ser Trp Glu Glu Asn Asn Leu Asp Asn Val Val Ser Lys Leu Glu 
    450                 455                 460                 


Lys Ala Lys Gln Asn Arg Glu Lys Leu Ser Lys Lys Leu Gly Asp Phe 
465                 470                 475                 480 


Asp Lys Leu Asn Ala Gln Tyr His Asn Pro Glu Val Thr Val Ile Leu 
                485                 490                 495     


Lys His Asn Gly Lys Lys Val Glu Ser Lys Thr Val Arg Leu Lys Glu 
            500                 505                 510         


Gly Glu Lys Lys Thr Val Phe Phe Asn Trp Glu His Lys Gly Lys Gly 
        515                 520                 525             


Thr Ile Gln Ala Glu Ile Asn Pro Ala Asp Glu Asp Gly Ser Arg Leu 
    530                 535                 540                 


Asp Ile Lys Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile 
545                 550                 555                 560 


Tyr Glu Pro Ser Gln Glu Lys Ala Met Cys Gly Ala Thr Ser Val Lys 
                565                 570                 575     


Gly Val Val Glu Thr Val Ser Asn Arg Val Ser Val Glu Asp Thr Val 
            580                 585                 590         


Gly Glu Met Tyr His Glu Thr Leu Thr Gly Ser Ile Asp Lys Leu Val 
        595                 600                 605             


Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Thr Tyr Glu Leu Asp Gly 
    610                 615                 620                 


Lys Tyr Thr Asn Asn Trp Asp Gln Asn Tyr Gln Gly Val Phe Thr Val 
625                 630                 635                 640 


Ala Thr Ala Lys Tyr Pro Phe Ala Asp Glu Gly Leu Lys Leu Asn Gln 
                645                 650                 655     


Asp Leu Glu Lys Lys Glu Ile Lys Asp Asn Thr Ser Lys Phe Ile Pro 
            660                 665                 670         


Lys Asn Met Tyr Leu Ser Glu Lys Thr Gly Tyr Val Phe Asp Ser Lys 
        675                 680                 685             


Arg Pro Ile Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp 
    690                 695                 700                 


Gly Gly His Lys Trp Tyr Ala Pro Met Lys Thr Lys Asp Gly Lys Tyr 
705                 710                 715                 720 


Ser Phe Lys Val Glu Thr Lys Pro Thr Gly Ile Asn Glu Met Ser Leu 
                725                 730                 735     


Cys Met Thr Glu Glu Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe 
            740                 745                 750         


Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly 
        755                 760                 765             


Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr 
    770                 775                 780                 


Asp Trp Tyr Tyr Met Lys Asn Gly Asn Lys Asn Lys Ile Ser Gly Gly 
785                 790                 795                 800 


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
                805                 810                 815     


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Ala Lys 
            820                 825                 830         


Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys Ser 
        835                 840                 845             


Glu Val Glu Phe Ser His Glu Tyr Trp Met Arg His Ala Leu Thr Leu 
    850                 855                 860                 


Ala Lys Arg Ala Trp Asp Glu Arg Glu Val Pro Val Gly Ala Val Leu 
865                 870                 875                 880 


Val His Asn Asn Arg Val Ile Gly Glu Gly Trp Asn Arg Pro Ile Gly 
                885                 890                 895     


Arg His Asp Pro Thr Ala His Ala Glu Ile Met Ala Leu Arg Gln Gly 
            900                 905                 910         


Gly Leu Val Met Gln Asn Tyr Arg Leu Ile Asp Ala Thr Leu Tyr Val 
        915                 920                 925             


Thr Leu Glu Pro Cys Val Met Cys Ala Gly Ala Met Ile His Ser Arg 
    930                 935                 940                 


Ile Gly Arg Val Val Phe Gly Ala Arg Asp Ala Lys Thr Gly Ala Ala 
945                 950                 955                 960 


Gly Ser Leu Met Asp Val Leu His His Pro Gly Met Asn His Arg Val 
                965                 970                 975     


Glu Ile Thr Glu Gly Ile Leu Ala Asp Glu Cys Ala Ala Leu Leu Ser 
            980                 985                 990         


Asp Phe Phe Arg Met Arg Arg Gln  Glu Ile Lys Ala Gln  Lys Lys Ala 
        995                 1000                 1005             


Gln Ser  Ser Thr Asp Ser Gly  Gly Ser Ser Gly Gly  Ser Ser Gly 
    1010                 1015                 1020             


Ser Glu  Thr Pro Gly Thr Ser  Glu Ser Ala Thr Pro  Glu Ser Ser 
    1025                 1030                 1035             


Gly Gly  Ser Ser Gly Gly Ser  Ser Glu Val Glu Phe  Ser His Glu 
    1040                 1045                 1050             


Tyr Trp  Met Arg His Ala Leu  Thr Leu Ala Lys Arg  Ala Arg Asp 
    1055                 1060                 1065             


Glu Arg  Glu Val Pro Val Gly  Ala Val Leu Val Leu  Asn Asn Arg 
    1070                 1075                 1080             


Val Ile  Gly Glu Gly Trp Asn  Arg Ala Ile Gly Leu  His Asp Pro 
    1085                 1090                 1095             


Thr Ala  His Ala Glu Ile Met  Ala Leu Arg Gln Gly  Gly Leu Val 
    1100                 1105                 1110             


Met Gln  Asn Tyr Arg Leu Ile  Asp Ala Thr Leu Tyr  Val Thr Phe 
    1115                 1120                 1125             


Glu Pro  Cys Val Met Cys Ala  Gly Ala Met Ile His  Ser Arg Ile 
    1130                 1135                 1140             


Gly Arg  Val Val Phe Gly Val  Arg Asn Ala Lys Thr  Gly Ala Ala 
    1145                 1150                 1155             


Gly Ser  Leu Met Asp Val Leu  His Tyr Pro Gly Met  Asn His Arg 
    1160                 1165                 1170             


Val Glu  Ile Thr Glu Gly Ile  Leu Ala Asp Glu Cys  Ala Ala Leu 
    1175                 1180                 1185             


Leu Cys  Tyr Phe Phe Arg Met  Pro Arg Gln Val Phe  Asn Ala Gln 
    1190                 1195                 1200             


Lys Lys  Ala Gln Ser Ser Thr  Asp Ser Gly Gly Ser  Ser Gly Gly 
    1205                 1210                 1215             


Ser Ser  Gly Ser Glu Thr Pro  Gly Thr Ser Glu Ser  Ala Thr Pro 
    1220                 1225                 1230             


Glu Ser  Ser Gly Gly Ser Ser  Gly Gly Ser Ser Lys  Arg Pro Ala 
    1235                 1240                 1245             


Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys Lys Lys  
    1250                 1255                 1260 


<210> 68
<211> 1060
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 68
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Leu Lys Arg Gly Leu Leu Val Leu Cys Thr Ser Thr Ala Leu Ile 
        35                  40                  45              


Tyr Pro Ser Ile Val Asn Ala Lys Asn Asn Asp Val Pro Phe Tyr Asp 
    50                  55                  60                  


Gly Lys Asn Asp Thr Phe Leu Ser Ser Lys Tyr Leu Gln Leu Pro Gly 
65                  70                  75                  80  


Lys Tyr Phe Arg Pro Gly Ser Gly Tyr Ala Ser Lys Glu Ser Leu Tyr 
                85                  90                  95      


Arg Ala Asp Ile His Phe Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp 
            100                 105                 110         


Gly Asn Pro Lys Glu Asn Leu Val Gln Ala Glu Asp Ser Ser Glu Pro 
        115                 120                 125             


Tyr Ile Arg Ile Ala Asn Glu Gly Tyr Leu Asn Gly Ser Val Pro Ala 
    130                 135                 140                 


Gly Asp Arg Met Val Thr Glu Val Glu Arg Ile Asn Lys Tyr Val Ile 
145                 150                 155                 160 


Ser Asp Lys Tyr Trp Gly Asn Pro Asp Phe Val Leu Asp Asn Ile Asp 
                165                 170                 175     


Asn His Ser Ile Asn Thr Tyr Glu Thr Tyr Lys Glu Leu Gly Gln Phe 
            180                 185                 190         


Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala 
        195                 200                 205             


Gly Ala Val Glu Gly Ile Asn Lys Tyr Ser Leu Trp Tyr Val Arg Thr 
    210                 215                 220                 


Asn Lys Pro Glu Leu Lys Asp Phe Lys Ala Ser Ser Ser Thr Lys Asp 
225                 230                 235                 240 


Val Pro Val Lys Phe Thr Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn 
                245                 250                 255     


Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr 
            260                 265                 270         


Gln Ala Ala Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp Ile 
        275                 280                 285             


Thr Lys Asp Gly Glu Thr Val His His Gln Glu Asn Tyr Leu Arg Ser 
    290                 295                 300                 


Thr Pro Gln Lys Asp Asn Glu Arg Ser Asn Glu Gly Asp Ala Gly Lys 
305                 310                 315                 320 


Phe Val Lys Asp Asp Val Lys Trp Gln Pro Gln Met Cys Gly Gln Tyr 
                325                 330                 335     


Thr Ala Lys Ile Lys Val Leu Asp Ala Val Gln Arg Glu Ser Asn Glu 
            340                 345                 350         


Lys Asn Val Asp Phe Thr Ile Asp Gly Asn Cys Gly Asn Glu Val Thr 
        355                 360                 365             


Pro Asn Pro Asp Pro Gly Asp Glu Asp Asp Phe Lys Tyr Ile Ile Asp 
    370                 375                 380                 


Phe Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Glu Gly Lys Asn 
385                 390                 395                 400 


Ile Lys Thr Arg Val Asp Val Ser Arg Asp Asn Phe Lys Pro Glu Arg 
                405                 410                 415     


Asp Gln Tyr Arg Val Lys Val Asn Asn Asn Ile Asn Lys Ser Gln Gln 
            420                 425                 430         


Glu Val Asn Ser Ser Glu Ser Glu Arg Asp Ser Ala Gln Ser Ser Leu 
        435                 440                 445             


Ser Tyr Cys Arg Arg Asn Pro Ile His Glu Val Asp Ala Glu Gly Lys 
    450                 455                 460                 


Asp His Tyr Tyr Asp Arg Asp Cys Ser Trp Glu Glu Asn Lys Leu Asp 
465                 470                 475                 480 


Ser Ala Ala Ser Lys Leu Asp Asn Ala Arg Gln Lys Phe Glu Lys Glu 
                485                 490                 495     


Lys Asn Lys Leu Lys Lys Leu Asp Val Leu Glu Glu Lys Tyr Thr Asn 
            500                 505                 510         


Pro Glu Thr Val Val Val Leu Lys His Asn Gly Gln Gln Val Ala Leu 
        515                 520                 525             


Gln Lys Val Arg Leu Thr Glu Gly Glu Lys Lys Thr Leu Asn Leu Asp 
    530                 535                 540                 


Trp Gln His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala 
545                 550                 555                 560 


Gly Asn Arg Ile Asp Ile Glu Glu Thr Thr Tyr Lys Asn Asn Pro Ile 
                565                 570                 575     


Lys Thr Ala Ile Tyr Glu Pro Ser Lys Glu Lys Ala Met Cys Gly Val 
            580                 585                 590         


Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Glu Arg Val Ser Lys 
        595                 600                 605             


Glu Asp Ile Thr Gly Glu Met Tyr Tyr Glu Thr Leu Thr Gly Ser Ile 
    610                 615                 620                 


Asp Asn Leu Ala Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Ser Tyr 
625                 630                 635                 640 


Glu Val Asn Gly Lys Tyr Lys Asn Asp Trp Asn Ala Asn Tyr Pro Gly 
                645                 650                 655     


Val Phe Thr Ala Ala Lys Ala Gln Tyr Pro Phe Ala Asp Glu Gly Leu 
            660                 665                 670         


Lys Ser Thr Gln Asp Leu Glu Lys Lys Glu Leu Lys Asp Asn Thr Ala 
        675                 680                 685             


Lys Phe Leu Pro Lys Asn Met Tyr Leu Ser Glu Ala Thr Gly His Val 
    690                 695                 700                 


Phe Asp Ser Lys Arg Pro Thr Lys Ser Leu Tyr Trp Asp Gly Gln Glu 
705                 710                 715                 720 


Lys Ile Ile Asp Gly Gly Gln Lys Trp Tyr Ser Pro Leu Lys Thr Lys 
                725                 730                 735     


Asp Gly Val Tyr Thr Phe Asn Val Glu Thr Ala Pro Ala Gly Ile Asn 
            740                 745                 750         


Glu Met Ser Leu Cys Leu Thr Glu Gln Val Glu Ile Lys Gly Val Ala 
        755                 760                 765             


Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro 
    770                 775                 780                 


Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu 
785                 790                 795                 800 


His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Thr Gly Lys Ser Gly Gly 
                805                 810                 815     


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
            820                 825                 830         


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Glu Ala 
        835                 840                 845             


Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His Ile Phe Thr 
    850                 855                 860                 


Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr 
865                 870                 875                 880 


Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln His 
                885                 890                 895     


Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr 
            900                 905                 910         


Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln 
        915                 920                 925             


Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser 
    930                 935                 940                 


Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln 
945                 950                 955                 960 


Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp 
                965                 970                 975     


Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly 
            980                 985                 990         


Ala Gln Val Ser Ile Met Thr Tyr  Asp Glu Phe Lys His  Cys Trp Asp 
        995                 1000                 1005             


Thr Phe  Val Asp His Gln Gly  Cys Pro Phe Gln Pro  Trp Asp Gly 
    1010                 1015                 1020             


Leu Asp  Glu His Ser Gln Ala  Leu Ser Gly Arg Leu  Arg Ala Ile 
    1025                 1030                 1035             


Leu Gln  Asn Gln Gly Asn Lys  Arg Pro Ala Ala Thr  Lys Lys Ala 
    1040                 1045                 1050             


Gly Gln  Ala Lys Lys Lys Lys  
    1055                 1060 


<210> 69
<211> 1037
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Asn Asn Asp Val Pro Phe Tyr Asp Gly Lys Asn Asp Thr Phe Leu 
        35                  40                  45              


Ser Ser Lys Tyr Leu Gln Leu Pro Gly Lys Tyr Phe Arg Pro Gly Ser 
    50                  55                  60                  


Gly Tyr Ala Ser Lys Glu Ser Leu Tyr Arg Ala Asp Ile His Phe Pro 
65                  70                  75                  80  


Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn Leu 
                85                  90                  95      


Val Gln Ala Glu Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ala Asn Glu 
            100                 105                 110         


Gly Tyr Leu Asn Gly Ser Val Pro Ala Gly Asp Arg Met Val Thr Glu 
        115                 120                 125             


Val Glu Arg Ile Asn Lys Tyr Val Ile Ser Asp Lys Tyr Trp Gly Asn 
    130                 135                 140                 


Pro Asp Phe Val Leu Asp Asn Ile Asp Asn His Ser Ile Asn Thr Tyr 
145                 150                 155                 160 


Glu Thr Tyr Lys Glu Leu Gly Gln Phe Tyr Trp Ile Arg Asp Ile Ala 
                165                 170                 175     


Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Glu Gly Ile Asn 
            180                 185                 190         


Lys Tyr Ser Leu Trp Tyr Val Arg Thr Asn Lys Pro Glu Leu Lys Asp 
        195                 200                 205             


Phe Lys Ala Ser Ser Ser Thr Lys Asp Val Pro Val Lys Phe Thr Phe 
    210                 215                 220                 


Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg Asp 
225                 230                 235                 240 


Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ala Ala Ala Gly Glu Arg 
                245                 250                 255     


Asn Arg Val Lys Trp Met Leu Asp Ile Thr Lys Asp Gly Glu Thr Val 
            260                 265                 270         


His His Gln Glu Asn Tyr Leu Arg Ser Thr Pro Gln Lys Asp Asn Glu 
        275                 280                 285             


Arg Ser Asn Glu Gly Asp Ala Gly Lys Phe Val Lys Asp Asp Val Lys 
    290                 295                 300                 


Trp Gln Pro Gln Met Cys Gly Gln Tyr Thr Ala Lys Ile Lys Val Leu 
305                 310                 315                 320 


Asp Ala Val Gln Arg Glu Ser Asn Glu Lys Asn Val Asp Phe Thr Ile 
                325                 330                 335     


Asp Gly Asn Cys Gly Asn Glu Val Thr Pro Asn Pro Asp Pro Gly Asp 
            340                 345                 350         


Glu Asp Asp Phe Lys Tyr Ile Ile Asp Phe Ser Ala Asp Arg Ile Glu 
        355                 360                 365             


Gly Glu Thr Ala Arg Glu Gly Lys Asn Ile Lys Thr Arg Val Asp Val 
    370                 375                 380                 


Ser Arg Asp Asn Phe Lys Pro Glu Arg Asp Gln Tyr Arg Val Lys Val 
385                 390                 395                 400 


Asn Asn Asn Ile Asn Lys Ser Gln Gln Glu Val Asn Ser Ser Glu Ser 
                405                 410                 415     


Glu Arg Asp Ser Ala Gln Ser Ser Leu Ser Tyr Cys Arg Arg Asn Pro 
            420                 425                 430         


Ile His Glu Val Asp Ala Glu Gly Lys Asp His Tyr Tyr Asp Arg Asp 
        435                 440                 445             


Cys Ser Trp Glu Glu Asn Lys Leu Asp Ser Ala Ala Ser Lys Leu Asp 
    450                 455                 460                 


Asn Ala Arg Gln Lys Phe Glu Lys Glu Lys Asn Lys Leu Lys Lys Leu 
465                 470                 475                 480 


Asp Val Leu Glu Glu Lys Tyr Thr Asn Pro Glu Thr Val Val Val Leu 
                485                 490                 495     


Lys His Asn Gly Gln Gln Val Ala Leu Gln Lys Val Arg Leu Thr Glu 
            500                 505                 510         


Gly Glu Lys Lys Thr Leu Asn Leu Asp Trp Gln His Lys Gly Lys Gly 
        515                 520                 525             


Thr Ile Gln Ala Glu Ile Asn Pro Ala Gly Asn Arg Ile Asp Ile Glu 
    530                 535                 540                 


Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro 
545                 550                 555                 560 


Ser Lys Glu Lys Ala Met Cys Gly Val Thr Ser Val Lys Gly Val Val 
                565                 570                 575     


Glu Thr Val Ser Glu Arg Val Ser Lys Glu Asp Ile Thr Gly Glu Met 
            580                 585                 590         


Tyr Tyr Glu Thr Leu Thr Gly Ser Ile Asp Asn Leu Ala Pro Ser Lys 
        595                 600                 605             


Leu His Ser Gly Tyr Gly Phe Ser Tyr Glu Val Asn Gly Lys Tyr Lys 
    610                 615                 620                 


Asn Asp Trp Asn Ala Asn Tyr Pro Gly Val Phe Thr Ala Ala Lys Ala 
625                 630                 635                 640 


Gln Tyr Pro Phe Ala Asp Glu Gly Leu Lys Ser Thr Gln Asp Leu Glu 
                645                 650                 655     


Lys Lys Glu Leu Lys Asp Asn Thr Ala Lys Phe Leu Pro Lys Asn Met 
            660                 665                 670         


Tyr Leu Ser Glu Ala Thr Gly His Val Phe Asp Ser Lys Arg Pro Thr 
        675                 680                 685             


Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp Gly Gly Gln 
    690                 695                 700                 


Lys Trp Tyr Ser Pro Leu Lys Thr Lys Asp Gly Val Tyr Thr Phe Asn 
705                 710                 715                 720 


Val Glu Thr Ala Pro Ala Gly Ile Asn Glu Met Ser Leu Cys Leu Thr 
                725                 730                 735     


Glu Gln Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg 
            740                 745                 750         


Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly Val Gly Trp 
        755                 760                 765             


Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr Asp Trp Tyr 
    770                 775                 780                 


Tyr Met Lys Thr Gly Lys Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly 
785                 790                 795                 800 


Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly 
                805                 810                 815     


Gly Ser Ser Gly Gly Ser Met Glu Ala Ser Pro Ala Ser Gly Pro Arg 
            820                 825                 830         


His Leu Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile 
        835                 840                 845             


Gly Arg His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn 
    850                 855                 860                 


Gly Thr Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His Asn Gln 
865                 870                 875                 880 


Ala Lys Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg 
                885                 890                 895     


Phe Leu Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr 
            900                 905                 910         


Arg Val Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys 
        915                 920                 925             


Ala Gly Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu 
    930                 935                 940                 


Arg Ile Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu 
945                 950                 955                 960 


Ala Leu Gln Met Leu Arg Asp Ala Gly Ala Gln Val Ser Ile Met Thr 
                965                 970                 975     


Tyr Asp Glu Phe Lys His Cys Trp Asp Thr Phe Val Asp His Gln Gly 
            980                 985                 990         


Cys Pro Phe Gln Pro Trp Asp Gly  Leu Asp Glu His Ser  Gln Ala Leu 
        995                 1000                 1005             


Ser Gly  Arg Leu Arg Ala Ile  Leu Gln Asn Gln Gly  Asn Lys Arg 
    1010                 1015                 1020             


Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala Lys Lys  Lys Lys 
    1025                 1030                 1035         


<210> 70
<211> 1067
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 70
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Phe Lys Lys Gly Ile Phe Val Leu Phe Thr Ser Val Leu Leu Ser 
        35                  40                  45              


Ala Pro Asn Ser Ala Asp Ala Lys Asn Asn Asp Val Pro Phe Tyr Asn 
    50                  55                  60                  


Gly Asn Glu Asp Thr Phe Val Lys Ser Ala Gln Leu Gln Met Pro Gly 
65                  70                  75                  80  


Lys Tyr Phe Arg Pro Gly Ser Tyr Ser Pro Gln Gly Thr Asp Leu Met 
                85                  90                  95      


Tyr Lys Gly Asp Ile His Tyr Pro Ala Val Tyr Asn Gly Ser Phe Asn 
            100                 105                 110         


Trp Gly Asn Pro Lys Glu Asn Leu Val Gln Gly Asn Asp Ser Ser Glu 
        115                 120                 125             


Pro Tyr Ile Arg Ile Ser Asn Glu Gly Tyr Phe Asn Ser Ser Val Pro 
    130                 135                 140                 


Val Gly Asp Arg Met Val Thr Glu Ile Glu Arg Val Thr Glu Pro Ile 
145                 150                 155                 160 


Ile Ser Asn Lys Tyr Trp Gly Asn Pro Glu Phe Val Leu Gly Asn Ile 
                165                 170                 175     


Lys Glu His Ile Ile Arg Asn Asp Lys Thr Asn Glu Met Tyr Gly Gln 
            180                 185                 190         


Phe Tyr Trp Ile Arg Asp Ile Ala Tyr Leu Ser Gly Gly Tyr Ala Gly 
        195                 200                 205             


Ala Gly Ala Val Asp Asn Val Asn Asn Tyr Asn Leu Trp Tyr Val Arg 
    210                 215                 220                 


Thr Ser Lys Pro Glu Leu Lys Glu Phe Lys Ala Ser Ser Gly Lys Lys 
225                 230                 235                 240 


Asp Asp Pro Val Lys Phe Ile Phe Asn Gly Phe Glu Tyr Val Ser Lys 
                245                 250                 255     


Asn Lys Gly Tyr Asn Asp Arg Asp Pro Asn Gly Thr Thr Val Asn Pro 
            260                 265                 270         


Tyr Gln Ser Glu Ala Gly Glu Arg Asn Arg Val Lys Trp Met Leu Asp 
        275                 280                 285             


Ile Ile Lys Asn Gly Glu Thr Val His His Gln Gly Asn Tyr Leu Arg 
    290                 295                 300                 


Ser Asn Pro Gln Lys Asn Asn Asp Lys Pro Asn Glu Gly Asp Ala Gly 
305                 310                 315                 320 


Tyr Phe Ser Lys Glu Gly Ile Pro Phe Tyr Pro Gln Glu Cys Gly Arg 
                325                 330                 335     


Tyr Thr Ala Lys Leu Lys Leu Ile Asp Ala Val Gln Arg Glu Ser Thr 
            340                 345                 350         


Glu Lys Val Val Asp Phe Val Val Asp Gly Ser Cys Gly Thr Gln Val 
        355                 360                 365             


Pro Pro Thr Thr Asp Pro Val Asp Gly Glu Phe Asn Tyr Lys Ile Asp 
    370                 375                 380                 


Tyr Ser Ala Asp Arg Ile Glu Gly Glu Thr Ala Arg Lys Asp Lys Glu 
385                 390                 395                 400 


Ile Lys Thr Arg Val Asp Val Ser Arg Ala Ser Phe Lys Glu Glu His 
                405                 410                 415     


Asp Gln Tyr Arg Ala Lys Leu Asp Glu Glu Phe Lys Lys Tyr Gln Lys 
            420                 425                 430         


Glu Val Asp Ala Tyr Ile Ser Glu Arg Asp Ser Ala Gln Asp Ser Leu 
        435                 440                 445             


Asn Tyr Cys Arg Arg Asn Pro Ile Arg Glu Glu Asp Glu Lys Gly Gly 
    450                 455                 460                 


Val His Tyr Arg Asp Arg Asp Cys Ser Trp Glu Glu Asn Asn Leu Asp 
465                 470                 475                 480 


Asn Val Val Ser Lys Leu Glu Lys Ala Lys Gln Asn Arg Glu Lys Leu 
                485                 490                 495     


Ser Lys Lys Leu Gly Asp Phe Asp Lys Leu Asn Ala Gln Tyr His Asn 
            500                 505                 510         


Pro Glu Val Thr Val Ile Leu Lys His Asn Gly Lys Lys Val Glu Ser 
        515                 520                 525             


Lys Thr Val Arg Leu Lys Glu Gly Glu Lys Lys Thr Val Phe Phe Asn 
    530                 535                 540                 


Trp Glu His Lys Gly Lys Gly Thr Ile Gln Ala Glu Ile Asn Pro Ala 
545                 550                 555                 560 


Asp Glu Asp Gly Ser Arg Leu Asp Ile Lys Glu Thr Thr Tyr Lys Asn 
                565                 570                 575     


Asn Pro Ile Lys Thr Ala Ile Tyr Glu Pro Ser Gln Glu Lys Ala Met 
            580                 585                 590         


Cys Gly Ala Thr Ser Val Lys Gly Val Val Glu Thr Val Ser Asn Arg 
        595                 600                 605             


Val Ser Val Glu Asp Thr Val Gly Glu Met Tyr His Glu Thr Leu Thr 
    610                 615                 620                 


Gly Ser Ile Asp Lys Leu Val Pro Ser Lys Leu His Ser Gly Tyr Gly 
625                 630                 635                 640 


Phe Thr Tyr Glu Leu Asp Gly Lys Tyr Thr Asn Asn Trp Asp Gln Asn 
                645                 650                 655     


Tyr Gln Gly Val Phe Thr Val Ala Thr Ala Lys Tyr Pro Phe Ala Asp 
            660                 665                 670         


Glu Gly Leu Lys Leu Asn Gln Asp Leu Glu Lys Lys Glu Ile Lys Asp 
        675                 680                 685             


Asn Thr Ser Lys Phe Ile Pro Lys Asn Met Tyr Leu Ser Glu Lys Thr 
    690                 695                 700                 


Gly Tyr Val Phe Asp Ser Lys Arg Pro Ile Lys Ser Leu Tyr Trp Asp 
705                 710                 715                 720 


Gly Gln Glu Lys Ile Ile Asp Gly Gly His Lys Trp Tyr Ala Pro Met 
                725                 730                 735     


Lys Thr Lys Asp Gly Lys Tyr Ser Phe Lys Val Glu Thr Lys Pro Thr 
            740                 745                 750         


Gly Ile Asn Glu Met Ser Leu Cys Met Thr Glu Glu Val Glu Ile Lys 
        755                 760                 765             


Gly Val Ala Tyr Asp Asp Phe Ile Lys Arg Arg Val Phe Pro Asp Asp 
    770                 775                 780                 


Pro Phe Pro Gly Gly Ser Gly Val Gly Trp Asn Trp Val Gly Lys Glu 
785                 790                 795                 800 


Glu Leu Leu His Lys Leu Thr Asp Trp Tyr Tyr Met Lys Asn Gly Asn 
                805                 810                 815     


Lys Asn Lys Ile Ser Gly Gly Ser Ser Gly Gly Ser Ser Gly Ser Glu 
            820                 825                 830         


Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Ser Gly Gly Ser 
        835                 840                 845             


Ser Gly Gly Ser Met Glu Ala Ser Pro Ala Ser Gly Pro Arg His Leu 
    850                 855                 860                 


Met Asp Pro His Ile Phe Thr Ser Asn Phe Asn Asn Gly Ile Gly Arg 
865                 870                 875                 880 


His Lys Thr Tyr Leu Cys Tyr Glu Val Glu Arg Leu Asp Asn Gly Thr 
                885                 890                 895     


Ser Val Lys Met Asp Gln His Arg Gly Phe Leu His Asn Gln Ala Lys 
            900                 905                 910         


Asn Leu Leu Cys Gly Phe Tyr Gly Arg His Ala Glu Leu Arg Phe Leu 
        915                 920                 925             


Asp Leu Val Pro Ser Leu Gln Leu Asp Pro Ala Gln Ile Tyr Arg Val 
    930                 935                 940                 


Thr Trp Phe Ile Ser Trp Ser Pro Cys Phe Ser Trp Gly Cys Ala Gly 
945                 950                 955                 960 


Glu Val Arg Ala Phe Leu Gln Glu Asn Thr His Val Arg Leu Arg Ile 
                965                 970                 975     


Phe Ala Ala Arg Ile Tyr Asp Tyr Asp Pro Leu Tyr Lys Glu Ala Leu 
            980                 985                 990         


Gln Met Leu Arg Asp Ala Gly Ala  Gln Val Ser Ile Met  Thr Tyr Asp 
        995                 1000                 1005             


Glu Phe  Lys His Cys Trp Asp  Thr Phe Val Asp His  Gln Gly Cys 
    1010                 1015                 1020             


Pro Phe  Gln Pro Trp Asp Gly  Leu Asp Glu His Ser  Gln Ala Leu 
    1025                 1030                 1035             


Ser Gly  Arg Leu Arg Ala Ile  Leu Gln Asn Gln Gly  Asn Lys Arg 
    1040                 1045                 1050             


Pro Ala  Ala Thr Lys Lys Ala  Gly Gln Ala Lys Lys  Lys Lys 
    1055                 1060                 1065         


<210> 71
<211> 1044
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 71
Met Ala Pro Lys Lys Lys Arg Lys Val Asp Tyr Lys Asp His Asp Gly 
1               5                   10                  15      


Asp Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Met 
            20                  25                  30          


Lys Asn Asn Asp Val Pro Phe Tyr Asn Gly Asn Glu Asp Thr Phe Val 
        35                  40                  45              


Lys Ser Ala Gln Leu Gln Met Pro Gly Lys Tyr Phe Arg Pro Gly Ser 
    50                  55                  60                  


Tyr Ser Pro Gln Gly Thr Asp Leu Met Tyr Lys Gly Asp Ile His Tyr 
65                  70                  75                  80  


Pro Ala Val Tyr Asn Gly Ser Phe Asn Trp Gly Asn Pro Lys Glu Asn 
                85                  90                  95      


Leu Val Gln Gly Asn Asp Ser Ser Glu Pro Tyr Ile Arg Ile Ser Asn 
            100                 105                 110         


Glu Gly Tyr Phe Asn Ser Ser Val Pro Val Gly Asp Arg Met Val Thr 
        115                 120                 125             


Glu Ile Glu Arg Val Thr Glu Pro Ile Ile Ser Asn Lys Tyr Trp Gly 
    130                 135                 140                 


Asn Pro Glu Phe Val Leu Gly Asn Ile Lys Glu His Ile Ile Arg Asn 
145                 150                 155                 160 


Asp Lys Thr Asn Glu Met Tyr Gly Gln Phe Tyr Trp Ile Arg Asp Ile 
                165                 170                 175     


Ala Tyr Leu Ser Gly Gly Tyr Ala Gly Ala Gly Ala Val Asp Asn Val 
            180                 185                 190         


Asn Asn Tyr Asn Leu Trp Tyr Val Arg Thr Ser Lys Pro Glu Leu Lys 
        195                 200                 205             


Glu Phe Lys Ala Ser Ser Gly Lys Lys Asp Asp Pro Val Lys Phe Ile 
    210                 215                 220                 


Phe Asn Gly Phe Glu Tyr Val Ser Lys Asn Lys Gly Tyr Asn Asp Arg 
225                 230                 235                 240 


Asp Pro Asn Gly Thr Thr Val Asn Pro Tyr Gln Ser Glu Ala Gly Glu 
                245                 250                 255     


Arg Asn Arg Val Lys Trp Met Leu Asp Ile Ile Lys Asn Gly Glu Thr 
            260                 265                 270         


Val His His Gln Gly Asn Tyr Leu Arg Ser Asn Pro Gln Lys Asn Asn 
        275                 280                 285             


Asp Lys Pro Asn Glu Gly Asp Ala Gly Tyr Phe Ser Lys Glu Gly Ile 
    290                 295                 300                 


Pro Phe Tyr Pro Gln Glu Cys Gly Arg Tyr Thr Ala Lys Leu Lys Leu 
305                 310                 315                 320 


Ile Asp Ala Val Gln Arg Glu Ser Thr Glu Lys Val Val Asp Phe Val 
                325                 330                 335     


Val Asp Gly Ser Cys Gly Thr Gln Val Pro Pro Thr Thr Asp Pro Val 
            340                 345                 350         


Asp Gly Glu Phe Asn Tyr Lys Ile Asp Tyr Ser Ala Asp Arg Ile Glu 
        355                 360                 365             


Gly Glu Thr Ala Arg Lys Asp Lys Glu Ile Lys Thr Arg Val Asp Val 
    370                 375                 380                 


Ser Arg Ala Ser Phe Lys Glu Glu His Asp Gln Tyr Arg Ala Lys Leu 
385                 390                 395                 400 


Asp Glu Glu Phe Lys Lys Tyr Gln Lys Glu Val Asp Ala Tyr Ile Ser 
                405                 410                 415     


Glu Arg Asp Ser Ala Gln Asp Ser Leu Asn Tyr Cys Arg Arg Asn Pro 
            420                 425                 430         


Ile Arg Glu Glu Asp Glu Lys Gly Gly Val His Tyr Arg Asp Arg Asp 
        435                 440                 445             


Cys Ser Trp Glu Glu Asn Asn Leu Asp Asn Val Val Ser Lys Leu Glu 
    450                 455                 460                 


Lys Ala Lys Gln Asn Arg Glu Lys Leu Ser Lys Lys Leu Gly Asp Phe 
465                 470                 475                 480 


Asp Lys Leu Asn Ala Gln Tyr His Asn Pro Glu Val Thr Val Ile Leu 
                485                 490                 495     


Lys His Asn Gly Lys Lys Val Glu Ser Lys Thr Val Arg Leu Lys Glu 
            500                 505                 510         


Gly Glu Lys Lys Thr Val Phe Phe Asn Trp Glu His Lys Gly Lys Gly 
        515                 520                 525             


Thr Ile Gln Ala Glu Ile Asn Pro Ala Asp Glu Asp Gly Ser Arg Leu 
    530                 535                 540                 


Asp Ile Lys Glu Thr Thr Tyr Lys Asn Asn Pro Ile Lys Thr Ala Ile 
545                 550                 555                 560 


Tyr Glu Pro Ser Gln Glu Lys Ala Met Cys Gly Ala Thr Ser Val Lys 
                565                 570                 575     


Gly Val Val Glu Thr Val Ser Asn Arg Val Ser Val Glu Asp Thr Val 
            580                 585                 590         


Gly Glu Met Tyr His Glu Thr Leu Thr Gly Ser Ile Asp Lys Leu Val 
        595                 600                 605             


Pro Ser Lys Leu His Ser Gly Tyr Gly Phe Thr Tyr Glu Leu Asp Gly 
    610                 615                 620                 


Lys Tyr Thr Asn Asn Trp Asp Gln Asn Tyr Gln Gly Val Phe Thr Val 
625                 630                 635                 640 


Ala Thr Ala Lys Tyr Pro Phe Ala Asp Glu Gly Leu Lys Leu Asn Gln 
                645                 650                 655     


Asp Leu Glu Lys Lys Glu Ile Lys Asp Asn Thr Ser Lys Phe Ile Pro 
            660                 665                 670         


Lys Asn Met Tyr Leu Ser Glu Lys Thr Gly Tyr Val Phe Asp Ser Lys 
        675                 680                 685             


Arg Pro Ile Lys Ser Leu Tyr Trp Asp Gly Gln Glu Lys Ile Ile Asp 
    690                 695                 700                 


Gly Gly His Lys Trp Tyr Ala Pro Met Lys Thr Lys Asp Gly Lys Tyr 
705                 710                 715                 720 


Ser Phe Lys Val Glu Thr Lys Pro Thr Gly Ile Asn Glu Met Ser Leu 
                725                 730                 735     


Cys Met Thr Glu Glu Val Glu Ile Lys Gly Val Ala Tyr Asp Asp Phe 
            740                 745                 750         


Ile Lys Arg Arg Val Phe Pro Asp Asp Pro Phe Pro Gly Gly Ser Gly 
        755                 760                 765             


Val Gly Trp Asn Trp Val Gly Lys Glu Glu Leu Leu His Lys Leu Thr 
    770                 775                 780                 


Asp Trp Tyr Tyr Met Lys Asn Gly Asn Lys Asn Lys Ile Ser Gly Gly 
785                 790                 795                 800 


Ser Ser Gly Gly Ser Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 
                805                 810                 815     


Ala Thr Pro Glu Ser Ser Gly Gly Ser Ser Gly Gly Ser Met Glu Ala 
            820                 825                 830         


Ser Pro Ala Ser Gly Pro Arg His Leu Met Asp Pro His Ile Phe Thr 
        835                 840                 845             


Ser Asn Phe Asn Asn Gly Ile Gly Arg His Lys Thr Tyr Leu Cys Tyr 
    850                 855                 860                 


Glu Val Glu Arg Leu Asp Asn Gly Thr Ser Val Lys Met Asp Gln His 
865                 870                 875                 880 


Arg Gly Phe Leu His Asn Gln Ala Lys Asn Leu Leu Cys Gly Phe Tyr 
                885                 890                 895     


Gly Arg His Ala Glu Leu Arg Phe Leu Asp Leu Val Pro Ser Leu Gln 
            900                 905                 910         


Leu Asp Pro Ala Gln Ile Tyr Arg Val Thr Trp Phe Ile Ser Trp Ser 
        915                 920                 925             


Pro Cys Phe Ser Trp Gly Cys Ala Gly Glu Val Arg Ala Phe Leu Gln 
    930                 935                 940                 


Glu Asn Thr His Val Arg Leu Arg Ile Phe Ala Ala Arg Ile Tyr Asp 
945                 950                 955                 960 


Tyr Asp Pro Leu Tyr Lys Glu Ala Leu Gln Met Leu Arg Asp Ala Gly 
                965                 970                 975     


Ala Gln Val Ser Ile Met Thr Tyr Asp Glu Phe Lys His Cys Trp Asp 
            980                 985                 990         


Thr Phe Val Asp His Gln Gly Cys  Pro Phe Gln Pro Trp  Asp Gly Leu 
        995                 1000                 1005             


Asp Glu  His Ser Gln Ala Leu  Ser Gly Arg Leu Arg  Ala Ile Leu 
    1010                 1015                 1020             


Gln Asn  Gln Gly Asn Lys Arg  Pro Ala Ala Thr Lys  Lys Ala Gly 
    1025                 1030                 1035             


Gln Ala  Lys Lys Lys Lys 
    1040                 


<210> 72
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 72
acuacaacag ccacaacg                                                     18


<210> 73
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 73
aggagcggac agcagcttcc tatatctcgt acaggaccgt caacatggtt                  50


<210> 74
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 74
agccatgata tagacgttgt ggctgttgta gtaggaccgt caacatggtt                  50


<210> 75
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 75
agcggtggga aaggaatccc                                                   20


<210> 76
<211> 58
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 76
tggaatggga actaaagtaa tggcaaacga attcgtagga tcctctagag tcgacctg         58


<210> 77
<211> 61
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (37)..(41)
<223> a, c, t, g, unknown or other

<400> 77
acgaattcgt ttgccattac tttagttccc attccannnn naattcactg gccgtcgttt       60

t                                                                       61


<210> 78
<211> 56
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(26)
<223> a, c, t, g, unknown or other

<400> 78
aacgacggcc agtgaattnn nnnnnnacta caacagccac aacgtctata tcatgg           56


<210> 79
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 79
caggtcgact ctagaggatc ccatgatata gacgttgtgg ctgttgtagt                  50


<210> 80
<211> 143
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (52)..(59)
<223> a, c, t, g, unknown or other

<400> 80
tcgtcggcag cgtcagatgt gtataagaga cagaacgacg gccagtgaat tnnnnnnnna       60

ctacaacagc cacaacgtct atatcatggg atcctctaga gtcgacctgc tgtctcttat      120

acacatctcc gagcccacga gac                                              143


<210> 81
<211> 148
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> modified_base
<222> (52)..(56)
<223> a, c, t, g, unknown or other

<400> 81
tcgtcggcag cgtcagatgt gtataagaga cagaacgacg gccagtgaat tnnnnntgga       60

atgggaacta aagtaatggc aaacgaattc gtaggatcct ctagagtcga cctgctgtct      120

cttatacaca tctccgagcc cacgagac                                         148


<210> 82
<211> 51
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 82
tcgtcggcag cgtcagatgt gtataagaga cagaacgacg gccagtgaat t                51


<210> 83
<211> 54
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 83
gtctcgtggg ctcggagatg tgtataagag acagcaggtc gactctagag gatc             54


<210> 84
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 84
tcgtcggcag cgtca                                                        15


<210> 85
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 85
gtctcgtggg ctcggag                                                      17


<210> 86
<211> 18
<212> RNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 86
uggaauggga acuaaagu                                                     18


<210> 87
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (19)..(23)
<223> a, c, t, g, unknown or other

<400> 87
aacgacggcc agtgaattnn nnnactacaa cagccacaac gtctatatca tgg              53


<210> 88
<211> 1493
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 88
Met Pro Asn Glu Gly Ile Pro His Ser Ser Gln Thr Gln Glu Gln Asp 
1               5                   10                  15      


Cys Leu Gln Ser Gln Pro Val Ser Asn Asn Glu Glu Met Ala Ile Lys 
            20                  25                  30          


Gln Glu Ser Gly Gly Asp Gly Glu Val Glu Glu Tyr Leu Ser Phe Arg 
        35                  40                  45              


Ser Val Gly Asp Gly Leu Ser Thr Ser Ala Val Gly Cys Ala Ser Ala 
    50                  55                  60                  


Ala Pro Arg Arg Gly Pro Ala Leu Leu His Ile Asp Arg His Gln Ile 
65                  70                  75                  80  


Gln Ala Val Glu Pro Ser Ala Gln Ala Leu Glu Leu Gln Gly Leu Gly 
                85                  90                  95      


Val Asp Val Tyr Asp Gln Asp Val Leu Glu Gln Gly Val Leu Gln Gln 
            100                 105                 110         


Val Asp Asn Ala Ile His Glu Ala Ser Arg Ala Ser Gln Leu Val Asp 
        115                 120                 125             


Val Glu Lys Glu Tyr Arg Ser Val Leu Asp Asp Leu Thr Ser Cys Thr 
    130                 135                 140                 


Thr Ser Leu Arg Gln Ile Asn Lys Ile Ile Glu Gln Leu Ser Pro Gln 
145                 150                 155                 160 


Ala Ala Thr Ser Arg Asp Ile Asn Arg Lys Leu Asp Ser Val Lys Arg 
                165                 170                 175     


Gln Lys Tyr Asn Lys Glu Gln Gln Leu Lys Lys Ile Thr Ala Lys Gln 
            180                 185                 190         


Lys His Leu Gln Ala Ile Leu Gly Gly Ala Glu Val Lys Ile Glu Leu 
        195                 200                 205             


Asp His Ala Ser Leu Glu Glu Asp Ala Glu Pro Gly Pro Ser Ser Leu 
    210                 215                 220                 


Gly Ser Met Leu Met Pro Val Gln Glu Thr Ala Trp Glu Glu Leu Ile 
225                 230                 235                 240 


Arg Thr Gly Gln Met Thr Pro Phe Gly Thr Gln Ile Pro Gln Lys Gln 
                245                 250                 255     


Glu Lys Lys Pro Arg Lys Ile Met Leu Asn Glu Ala Ser Gly Phe Glu 
            260                 265                 270         


Lys Tyr Leu Ala Asp Gln Ala Lys Leu Ser Phe Glu Arg Lys Lys Gln 
        275                 280                 285             


Gly Cys Asn Lys Arg Ala Ala Arg Lys Ala Pro Ala Pro Val Thr Pro 
    290                 295                 300                 


Pro Ala Pro Val Gln Asn Lys Asn Lys Pro Asn Lys Lys Ala Arg Val 
305                 310                 315                 320 


Leu Ser Lys Lys Glu Glu Arg Leu Lys Lys His Ile Lys Lys Leu Gln 
                325                 330                 335     


Lys Arg Ala Leu Gln Phe Gln Gly Lys Val Gly Leu Pro Lys Ala Arg 
            340                 345                 350         


Arg Pro Trp Glu Ser Asp Met Arg Pro Glu Ala Glu Gly Asp Ser Glu 
        355                 360                 365             


Gly Glu Glu Ser Glu Tyr Phe Pro Thr Glu Glu Glu Glu Glu Glu Glu 
    370                 375                 380                 


Asp Asp Glu Val Glu Gly Ala Glu Ala Asp Leu Ser Gly Asp Gly Thr 
385                 390                 395                 400 


Asp Tyr Glu Leu Lys Pro Leu Pro Lys Gly Gly Lys Arg Gln Lys Lys 
                405                 410                 415     


Val Pro Val Gln Glu Ile Asp Asp Asp Phe Phe Pro Ser Ser Gly Glu 
            420                 425                 430         


Glu Ala Glu Ala Ala Ser Val Gly Glu Gly Gly Gly Gly Gly Arg Lys 
        435                 440                 445             


Val Gly Arg Tyr Arg Asp Asp Gly Asp Glu Asp Tyr Tyr Lys Gln Arg 
    450                 455                 460                 


Leu Arg Arg Trp Asn Lys Leu Arg Leu Gln Asp Lys Glu Lys Arg Leu 
465                 470                 475                 480 


Lys Leu Glu Asp Asp Ser Glu Glu Ser Asp Ala Glu Phe Asp Glu Gly 
                485                 490                 495     


Phe Lys Val Pro Gly Phe Leu Phe Lys Lys Leu Phe Lys Tyr Gln Gln 
            500                 505                 510         


Thr Gly Val Arg Trp Leu Trp Glu Leu His Cys Gln Gln Ala Gly Gly 
        515                 520                 525             


Ile Leu Gly Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Ile Ile Ala 
    530                 535                 540                 


Phe Leu Ala Gly Leu Ser Tyr Ser Lys Ile Arg Thr Arg Gly Ser Asn 
545                 550                 555                 560 


Tyr Arg Phe Glu Gly Leu Gly Pro Thr Val Ile Val Cys Pro Thr Thr 
                565                 570                 575     


Val Met His Gln Trp Val Lys Glu Phe His Thr Trp Trp Pro Pro Phe 
            580                 585                 590         


Arg Val Ala Ile Leu His Glu Thr Gly Ser Tyr Thr His Lys Lys Glu 
        595                 600                 605             


Lys Leu Ile Arg Asp Val Ala His Cys His Gly Ile Leu Ile Thr Ser 
    610                 615                 620                 


Tyr Ser Tyr Ile Arg Leu Met Gln Asp Asp Ile Ser Arg Tyr Asp Trp 
625                 630                 635                 640 


His Tyr Val Ile Leu Asp Glu Gly His Lys Ile Arg Asn Pro Asn Ala 
                645                 650                 655     


Ala Val Thr Leu Ala Cys Lys Gln Phe Arg Thr Pro His Arg Ile Ile 
            660                 665                 670         


Leu Ser Gly Ser Pro Met Gln Asn Asn Leu Arg Glu Leu Trp Ser Leu 
        675                 680                 685             


Phe Asp Phe Ile Phe Pro Gly Lys Leu Gly Thr Leu Pro Val Phe Met 
    690                 695                 700                 


Glu Gln Phe Ser Val Pro Ile Thr Met Gly Gly Tyr Ser Asn Ala Ser 
705                 710                 715                 720 


Pro Val Gln Val Lys Thr Ala Tyr Lys Cys Ala Cys Val Leu Arg Asp 
                725                 730                 735     


Thr Ile Asn Pro Tyr Leu Leu Arg Arg Met Lys Ser Asp Val Lys Met 
            740                 745                 750         


Ser Leu Ser Leu Pro Asp Lys Asn Glu Gln Val Leu Phe Cys Arg Leu 
        755                 760                 765             


Thr Asp Glu Gln His Lys Val Tyr Gln Asn Phe Val Asp Ser Lys Glu 
    770                 775                 780                 


Val Tyr Arg Ile Leu Asn Gly Glu Met Gln Ile Phe Ser Gly Leu Ile 
785                 790                 795                 800 


Ala Leu Arg Lys Ile Cys Asn His Pro Asp Leu Phe Ser Gly Gly Pro 
                805                 810                 815     


Lys Asn Leu Lys Gly Leu Pro Asp Asp Glu Leu Glu Glu Asp Gln Phe 
            820                 825                 830         


Gly Tyr Trp Lys Arg Ser Gly Lys Met Ile Val Val Glu Ser Leu Leu 
        835                 840                 845             


Lys Ile Trp His Lys Gln Gly Gln Arg Val Leu Leu Phe Ser Gln Ser 
    850                 855                 860                 


Arg Gln Met Leu Asp Ile Leu Glu Val Phe Leu Arg Ala Gln Lys Tyr 
865                 870                 875                 880 


Thr Tyr Leu Lys Met Asp Gly Thr Thr Thr Ile Ala Ser Arg Gln Pro 
                885                 890                 895     


Leu Ile Thr Arg Tyr Asn Glu Asp Thr Ser Ile Phe Val Phe Leu Leu 
            900                 905                 910         


Thr Thr Arg Val Gly Gly Leu Gly Val Asn Leu Thr Gly Ala Asn Arg 
        915                 920                 925             


Val Val Ile Tyr Asp Pro Asp Trp Asn Pro Ser Thr Asp Thr Gln Ala 
    930                 935                 940                 


Arg Glu Arg Ala Trp Arg Ile Gly Gln Lys Lys Gln Val Thr Val Tyr 
945                 950                 955                 960 


Arg Leu Leu Thr Ala Gly Thr Ile Glu Glu Lys Ile Tyr His Arg Gln 
                965                 970                 975     


Ile Phe Lys Gln Phe Leu Thr Asn Arg Val Leu Lys Asp Pro Lys Gln 
            980                 985                 990         


Arg Arg Phe Phe Lys Ser Asn Asp  Leu Tyr Glu Leu Phe  Thr Leu Thr 
        995                 1000                 1005             


Ser Pro  Asp Ala Ser Gln Ser  Thr Glu Thr Ser Ala  Ile Phe Ala 
    1010                 1015                 1020             


Gly Thr  Gly Ser Asp Val Gln  Thr Pro Lys Cys His  Leu Lys Arg 
    1025                 1030                 1035             


Arg Ile  Gln Pro Ala Phe Gly  Ala Asp His Asp Val  Pro Lys Arg 
    1040                 1045                 1050             


Lys Lys  Phe Pro Ala Ser Asn  Ile Ser Val Asn Asp  Ala Thr Ser 
    1055                 1060                 1065             


Ser Glu  Glu Lys Ser Glu Ala  Lys Gly Ala Glu Val  Asn Ala Val 
    1070                 1075                 1080             


Thr Ser  Asn Arg Ser Asp Pro  Leu Lys Asp Asp Pro  His Met Ser 
    1085                 1090                 1095             


Ser Asn  Val Thr Ser Asn Asp  Arg Leu Gly Glu Glu  Thr Asn Ala 
    1100                 1105                 1110             


Val Ser  Gly Pro Glu Glu Leu  Ser Val Ile Ser Gly  Asn Gly Glu 
    1115                 1120                 1125             


Cys Ser  Asn Ser Ser Gly Thr  Gly Lys Thr Ser Met  Pro Ser Gly 
    1130                 1135                 1140             


Asp Glu  Ser Ile Asp Glu Lys  Leu Gly Leu Ser Tyr  Lys Arg Glu 
    1145                 1150                 1155             


Arg Pro  Ser Gln Ala Gln Thr  Glu Ala Phe Trp Glu  Asn Lys Gln 
    1160                 1165                 1170             


Met Glu  Asn Asn Phe Tyr Lys  His Lys Ser Lys Thr  Lys His His 
    1175                 1180                 1185             


Ser Val  Ala Glu Glu Glu Thr  Leu Glu Lys His Leu  Arg Pro Lys 
    1190                 1195                 1200             


Gln Lys  Pro Lys Asn Ser Lys  His Cys Arg Asp Ala  Lys Phe Glu 
    1205                 1210                 1215             


Gly Thr  Arg Ile Pro His Leu  Val Lys Lys Arg Arg  Tyr Gln Lys 
    1220                 1225                 1230             


Gln Asp  Ser Glu Asn Lys Ser  Glu Ala Lys Glu Gln  Ser Asn Asp 
    1235                 1240                 1245             


Asp Tyr  Val Leu Glu Lys Leu  Phe Lys Lys Ser Val  Gly Val His 
    1250                 1255                 1260             


Ser Val  Met Lys His Asp Ala  Ile Met Asp Gly Ala  Ser Pro Asp 
    1265                 1270                 1275             


Tyr Val  Leu Val Glu Ala Glu  Ala Asn Arg Val Ala  Gln Asp Ala 
    1280                 1285                 1290             


Leu Lys  Ala Leu Arg Leu Ser  Arg Gln Arg Cys Leu  Gly Ala Val 
    1295                 1300                 1305             


Ser Gly  Val Pro Thr Trp Thr  Gly His Arg Gly Ile  Ser Gly Ala 
    1310                 1315                 1320             


Pro Ala  Gly Lys Lys Ser Arg  Phe Gly Lys Lys Arg  Asn Ser Asn 
    1325                 1330                 1335             


Phe Ser  Val Gln His Pro Ser  Ser Thr Ser Pro Thr  Glu Lys Cys 
    1340                 1345                 1350             


Gln Asp  Gly Ile Met Lys Lys  Glu Gly Lys Asp Asn  Val Pro Glu 
    1355                 1360                 1365             


His Phe  Ser Gly Arg Ala Glu  Asp Ala Asp Ser Ser  Ser Gly Pro 
    1370                 1375                 1380             


Leu Ala  Ser Ser Ser Leu Leu  Ala Lys Met Arg Ala  Arg Asn His 
    1385                 1390                 1395             


Leu Ile  Leu Pro Glu Arg Leu  Glu Ser Glu Ser Gly  His Leu Gln 
    1400                 1405                 1410             


Glu Ala  Ser Ala Leu Leu Pro  Thr Thr Glu His Asp  Asp Leu Leu 
    1415                 1420                 1425             


Val Glu  Met Arg Asn Phe Ile  Ala Phe Gln Ala His  Thr Asp Gly 
    1430                 1435                 1440             


Gln Ala  Ser Thr Arg Glu Ile  Leu Gln Glu Phe Glu  Ser Lys Leu 
    1445                 1450                 1455             


Ser Ala  Ser Gln Ser Cys Val  Phe Arg Glu Leu Leu  Arg Asn Leu 
    1460                 1465                 1470             


Cys Thr  Phe His Arg Thr Ser  Gly Gly Glu Gly Ile  Trp Lys Leu 
    1475                 1480                 1485             


Lys Pro  Glu Tyr Cys 
    1490             


<210> 89
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 89
Met Lys Thr Thr Thr Gln Glu Leu Lys Gln Tyr Ile Thr Arg Leu Phe 
1               5                   10                  15      


Gln Leu Ser Asn Asn Glu Thr Trp Glu Cys Glu Ala Leu Glu Glu Ala 
            20                  25                  30          


Ala Glu Asn Ile Leu Pro Glu Arg Phe Ile Asn Asn Ser Leu Leu Ala 
        35                  40                  45              


His Leu Thr Leu Asn Thr Tyr Thr Tyr Tyr Asn Asp Glu Leu His Glu 
    50                  55                  60                  


Leu Ser Ile Tyr Pro Phe Leu Met Tyr Ala Asn Asp Gln Leu Ile Ser 
65                  70                  75                  80  


Ile Gly Tyr Leu Asp His Phe Asp Met Asp Phe Leu Tyr Leu Thr Asp 
                85                  90                  95      


Thr Lys Asn Thr Ile Ile Asp Glu Arg His Leu Leu Lys Gln Gly Glu 
            100                 105                 110         


Asn Asn His Glu 
        115     


<210> 90
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 90
Thr Asn Leu Ser Asp His Glu Lys Glu Thr Gly Lys Gln Leu Val Ile 
1               5                   10                  15      


Gln Glu Ser Ile Leu Met Leu Pro Glu Glu Val Glu Glu Val Ile Gly 
            20                  25                  30          


Asn Lys Pro Glu Ser Asp Ile Leu Val His Thr Ala Tyr Asp Glu Ser 
        35                  40                  45              


Thr Asp Glu Asn Val Met Leu Leu Thr Ser Asp Ala Pro Glu Tyr Lys 
    50                  55                  60                  


Pro Trp Ala Leu Val Ile Gln Asp Ser Asn Gly Glu Asn Lys Ile Lys 
65                  70                  75                  80  


Met Leu 
        


