                         SEQUENCE LISTING

<110>  St. Jude Children's Research Hospital, Inc.
       Zhou, Sheng
       Sorrentino, Brian
       Cheng, Yong
 
<120>  GENOMIC INSULATOR ELEMENT EXHIBITING ENHANCER BLOCKING ACTIVITIES
        IN LYMPHOCYTES AND USES THEREOF

<130>  SJ0089WO

<150>  US 63/024,651
<151>  2020-05-14

<160>  40    

<170>  PatentIn version 3.5

<210>  1
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  1
cactgccctc cagtggcca                                                    19


<210>  2
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  2
cagcgccacc tgcaggcca                                                    19


<210>  3
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  3
cttccagcag gaggaggca                                                    19


<210>  4
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  4
tggccgctag agggcacgc                                                    19


<210>  5
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  5
aagcaccatc tactggtct                                                    19


<210>  6
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  6
ctgccgccag atggcgctc                                                    19


<210>  7
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  7
tcagcactag atggcaccc                                                    19


<210>  8
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  8
gagtgacacc tagtggccc                                                    19


<210>  9
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  9
cagcgccatc tggcggccg                                                    19


<210>  10
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  10
tcgccagtag ggggcgcaa                                                    19


<210>  11
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  11
tgctgccccc tggtggcca                                                    19


<210>  12
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  12
tgctgctccc ttatggcca                                                    19


<210>  13
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  13
aggccaccag atggcattg                                                    19


<210>  14
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  14
ctgccacgag ggggcggca                                                    19


<210>  15
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  15
ttgcgccccc tgctggcga                                                    19


<210>  16
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  16
cgtcgccacc ttctggtaa                                                    19


<210>  17
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  17
cagtgccctc tggtggtag                                                    19


<210>  18
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  18
ttatgccccc tgcaggaca                                                    19


<210>  19
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  19
cgcccagaag gtggcggca                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  20
cactgccccc tagtggacc                                                    19


<210>  21
<211>  463
<212>  DNA
<213>  Homo sapiens

<400>  21
gcgaggggag acacaggggc cggggctgcg gcggctgagc tccctgggcg gctcggaacg       60

caaggggccg gcgagccgac gctgctgcag gaggctgcgg cgtggggcga ggttctcgct      120

acggcttcgt tcccgtcctc ccgcggccgc tctcccccgg aagccctcgg aggcagcacg      180

atggacgtgg ccacactgcc ctccagtggc cagctcgccg aacaacacgt ctgggcccct      240

tttgggggtc tgggtgacgt gtccaccctc tctctgccct ttgctacatt tgaaggtggg      300

gtttgctcat ccatggttcc tcttacaggt caccaaagct gccacagtgc acactcaccc      360

aacagcaggg gatttgccgc cttcggtggt tctcaaactt cagtgtgcac aggaatcccc      420

ccttggacag ttctttcaaa cccggattgc tgggtccccc aac                        463


<210>  22
<211>  394
<212>  DNA
<213>  Homo sapiens

<400>  22
ctgacccgta cccctgaacc gagcaagcct aggagcaggt gcgccggcgg cgctgtgaag       60

cggcactcat gacaggcagg ctgggcaccg ccaccccgaa acctccgagg gaggaccagc      120

cagcccaggt tggcgctgga gctgcagcgc cacctgcagg ccaaggagtc tttttctggg      180

aggctggagc tgcagcgcca cctgcaggcc aaggagtctt tttctgggag gctggagctg      240

cagcgccacc tgcaggccaa ggagtctttt tctgggaggc tggagctgca gatgcagtga      300

agtcacaggt tccgtgatgt cacaggtggg caggcgcact ggtctgtaac ggattggctt      360

ggccttaccc acgaggcttt gcggtggctg ttgg                                  394


<210>  23
<211>  589
<212>  DNA
<213>  Homo sapiens

<400>  23
gtgctgggga ggcagtgagg gctgaaaaag gccagggagg gaagagggga ggggagggaa       60

gcagtaaggt ggagcaggcc tggccagaaa gagccaggaa taaagcttcc tctagtgtct      120

tgagcctagg ccttcttcct tcagtggaac ctccctttgc ttccagcagg aggaggcagg      180

agaacctagg tctacaggct ttcctgccat ggtcttaggg actggataag gcccaccttc      240

aggtttgggc accttccaag tggcctgtga acccctaaag ggcaagagct ggggtacgat      300

gtccctttgc cccagtgacc cagaagcagg ttcaatctgt gcctcacagc accaccgtgt      360

ggcttcccct gggactgcag ccgcctaact gggtgtggcc ctgagtgtgg agctggctac      420

tacaattcct ttgaatctgt cgatctaaaa taagtgaaaa ggccagaacc tagtttagag      480

agagtttatt caagcacaca tgttgaggac aggcctaccc aggaagcaca aattccaaag      540

aatggaagtc agccttcctg ttcgaaatgt aggagcttgg gatcattta                  589


<210>  24
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  24
tcccaaggct gctgcctgca tgccactccg tgaggaagtt gaaatacatg gtctctaaga       60

ttccttccag ctcttcacct catgagacat ataaatcaag taacattcgt tattgtgatt      120

agaaaagctg catttacaca cgttagccac tagatgggga cgtgcgattg ttacaatgct      180

gaaggtttcc cgtatttctt tattttttat ttggccgcta gagggcacgc ctgcactgca      240

cttaaagttg actactttca aggaaagaca aaggaattct tggatttctc cattttcctc      300

atcacctgtg cttatcagag aattccaggg gcaagctacc ctttccaatt catcactaac      360

ttataaacaa aattctaagg agtaaggaat gcttcttact tactt                      405


<210>  25
<211>  376
<212>  DNA
<213>  Homo sapiens

<400>  25
tacagaaatg caaaatgctc tggaaaatct gagcaagatt tcaggtccag gaagactggt       60

gagcaggtgt cagagagact tggtgggttg tcatcaagta ggactaccct tgaacctgtg      120

caaaagagac actaacttgg tgagctcctt ctcaaaggaa catatagggc cacagctggc      180

tcttactcat aagcaccatc tactggtctt taggccagac tgcacagccc aatataaaac      240

ctgcctagga aagtgcatag cctaagaccc tatccagcat attctacagt cacacaccct      300

aggaagggga ggaaatgtca agaaaaaaat atataaagaa acaaacaaaa aatcctatct      360

gcatgaaaat aattac                                                      376


<210>  26
<211>  322
<212>  DNA
<213>  Homo sapiens

<400>  26
gagtacgcct gcgcgtgccg ccatttcctg cagccgcaga ctctgcctgc ggtgctcgcc       60

gggaaatgag acgatcaaca aagaaaatgg ttgttttggg cgagatcgac cgtggagagg      120

ctttttctgc agcagtcccg gttcctgccg ccagatggcg ctcgaggatc acaaatgggt      180

ctagggttct cataatggcc ccgcctaaga aattttggat tctcctggcc cttcccccct      240

ttgtggggtc aacagcggat ttgggaatct ggtgaccaac acgtgcgcac tcccctaccc      300

ttgcccctac cgagccctcc ag                                               322


<210>  27
<211>  627
<212>  DNA
<213>  Homo sapiens

<400>  27
cttatctttt gattttttga tagtagccac tctgactgga gtgaggtgat gtctcactgc       60

agttttgatt tgcatttccc tgatgagtga tgttgggcac ctgttcatat agcacccggt      120

gccttatttt gtacatttgg tgaggtcttg gttccctgaa tattattatt gatacttgtg      180

ggcatgtgac aagtctgtgt gtcgaaagac taggtattta ttccagtctt caaagactga      240

cgttgtcccc gtccttccag agcctctaag ccttctgtta ccgtctctga acctctttca      300

ctgctgctgt ttcagcacta gatggcaccc taagcccacg tttgccacaa gtccgtggtt      360

tgtgtgttgc cacattttca gcactagagg gcgcgctgag cccaggtgtg cctgtgacct      420

tgtttccgag ggacctaaaa agcttcggtg agtttccgcc ttaggctggg gcaggtccag      480

atgctccatt ccggcgctgc agagttctgc ctagctctgg gcttcacttt ggtgggtcca      540

gcactgggct ccaaggcaac gtcttgaggc tacttctctc tcctttccct aagcagacgc      600

tgcctctctt tgtgcccggc ggcctgg                                          627


<210>  28
<211>  488
<212>  DNA
<213>  Homo sapiens

<400>  28
tgaattagcc ggtcgggtgg cccccagcct tatagcttcg aattctgtga tcctatttta       60

gacccagact tgtccgcgaa gggaaatgaa gaggcgcgga aggcttggag cgtgaaccaa      120

aaaacaatgg gtggggatcg tctaaccagc tcccttccct agaagggcgg aaacggcttt      180

cgaagcatcc gcgattctct ttattgaatc ttgagtgaca cctagtggcc catccgcctc      240

accgtcacgg cgatgctggt ttcactgggc ttttcagaag gcgtgctggc ctgcccatgg      300

ttctcggcta aaagactttg gagcgtaggg tgccgatgaa gtttcctggg accttccgga      360

agcacttgct gtcccgtcaa cagccctgta cctgcgatgc atgcaattct aatgaaaatg      420

cccttctcgt ctggagggct tgcttgagca catcctgagc tctcaggcag caaatataga      480

gtcgggtg                                                               488


<210>  29
<211>  416
<212>  DNA
<213>  Homo sapiens

<400>  29
gagcctctgc tctggggctg ccggtcgggc cgtgtgtgct gtgtctcttt aaggaccagg       60

cctcttcaag gcaagttccc tctgcagtcc agtcctgcct ctgcccgtcc tgcggcagag      120

agtgggggct ccccagcgcc atctggcggc cgcacagcag cacctcggcc accagaggct      180

tccagccaag cggcccgcaa gtgcctggac aaaaatctcc agcttggaca cagggctgca      240

ggctgctgtt gggaacacag ctgggggagt caggaggagc tccgtctggg aaggagagag      300

cagaagcccc caggagtgac atggggagaa tgatcatccc gccggacaaa accttcacta      360

aaatatcctc aaatgggccg ggtgtggcag ctcacacctg taatcccagc actttg          416


<210>  30
<211>  167
<212>  DNA
<213>  Homo sapiens

<400>  30
ctgtaagcaa gagggccctg cagttgtcct agtcgccagt agggggcgca atggcagagc       60

accgtgggca agctggtcct gtagtgcccg gctgcaagca gggggcgccc gaaacgggct      120

tttcagatta ctcaggttca actcgtctct gcgccgcgcc gccgggg                    167


<210>  31
<211>  352
<212>  DNA
<213>  Homo sapiens

<400>  31
tcaaagacag aatccaaaaa ggctgctttc ggggaaaagt ggcctgagag tcaggccttg       60

ttggacaagt tcccctaacg tgctaagcag agacctgttt cacaggccaa aagagcatgg      120

aagctcagcc agagggaccc aggcgggccc acctcacgcc tgtgttcctc ggcagcctct      180

gctgccccct ggtggccatg ctgtgcacac cgccaccaga cgagggcgcc acccacaggc      240

accacctgct cccaccctca ggcagtattt caatggtccc gtggctctgg gccacgccca      300

catgactagc agccacagct gatcccatgg cctgttggcc accccatcag ca              352


<210>  32
<211>  340
<212>  DNA
<213>  Homo sapiens

<400>  32
aaactcctag tctttctaac tttaataact gttcatttgc cactgtccca cagtggcttc       60

tgagatgtca gggacttctc agaggagctg gtggcccagg ctcgtgcttt agctgggctc      120

tcctattgag ctttctccag gctccagcga tgctcctttg cattctgctg ctcccttatg      180

gccatgactg taattacagc taagtttaca gccctggaag aggtttccaa gggagggagg      240

caggaatctg aaagaacatt ggagcatcaa ccaagaaaat aaagaatttg caaatgagga      300

aaaaaagaga gaagaaaaaa gagaaaagag gaggaggatg                            340


<210>  33
<211>  368
<212>  DNA
<213>  Homo sapiens

<400>  33
tctcaaccag ctcctgtgaa tgtggccttt tgggcacctt ccttatttcc ccagcagcct       60

ttcccagaca tggattttga tttctcgtct ttctttgtct acagccccag cataaatgcc      120

tgctctcaag cctcaatgtg gcatccaaga catgagccca ggatggtgcc tcaggttcac      180

caaggagtga agtccagcag gtagaggtta ctttacacaa ttccccagga ggccaccaga      240

tggcattgtc agatcatttt acacctactt actgggaagg ggggtgtttc aatagggtag      300

gtggttgaag taacaggtat tatgttggaa aaattatgac aaaaaaggtt gtattttatt      360

tgtggagc                                                               368


<210>  34
<211>  509
<212>  DNA
<213>  Homo sapiens

<400>  34
actccagcct gggtgacaca gcgagactcc atgccgtgac accagcacgt ggcgtgtcac       60

attattaagg attatacagc caacagttac tgggctggtt tcctttaatc ctcacagcag      120

gccctgtccg caagtctttc accgtttccc gtcaacactc cacctttcct gcccaaagtt      180

tggggttggg agggaattcc caggggttcc caggacttgg gctcgcctcc cagatcccgc      240

aacctttgcg tgcctagcct cggcaatgac cgcccatctg ccacgagggg gcggcagcgc      300

accgttcaga cgctgcgccc ctggtgcatt atgggtcgcg tagtctcaaa ggtggcataa      360

gcatcctgga acgcaaacgg catttcccag aaaactacgc gacaatctga gcctggtctt      420

gcccagagct ggaagctgag gtctcgcccc tgccggcgtt gcgggggatt gtgggatgta      480

ggcatttggc tccgcgctcc gcgaagggc                                        509


<210>  35
<211>  649
<212>  DNA
<213>  Homo sapiens

<400>  35
cgggtggaac ctgagtaatc tgaaaagccc ggttcgggtg ccccctgctt gtacccgggc       60

actacaggac ccgcttgccc acggtgctgt gccattgcgc cccctgctgg cgactagggc      120

aactgcaggg ccctcttcct tacagtggtg tccagcgccc cctgccggtg ccggggcacg      180

gcagggctct cttgctcgca gtatactggc ggcacgccgc ctgctggcag ctagggacat      240

tgcagggccc tcttgctcac attgtagtgg cagcacaccc gcctgctggc agctggggac      300

actgctgggc cctcttgctt gcagtgtagt cggggcatgc cctcttctgt ccgctggggg      360

cactacagga tcctcttgct cacagtgtag tggcagcacg ccccctgctg gcaaccaggg      420

cacttcacgg tcctcttgct catggtgtgg tgcccctacg ccacctcctg gcagctaagg      480

acactgcagg gccctcttgc tcacagtgta gtcgtcgttc gccccctgct ggcagctagg      540

gacactgccg ggccctcttg ctgacactgt cgtggctgca cgccacctgc aggcagatgg      600

ggactaggca gggccctctt gctcccggtg tgacggctgg cgtccccta                  649


<210>  36
<211>  379
<212>  DNA
<213>  Homo sapiens

<400>  36
attcggcatt gacgggtctc tggttcttca agttttcatc tgaaagtctc agtctttgct       60

atcacaacca acgccccctt cctacactcc aaggttgatg gaatgaaatg tcttggaatt      120

gagggtttaa ttaattcgga tcactggaga gaaagaaaag aaataacggg ggaaaaaaat      180

gtgttaattt tagggcttgg aattggaaac gtggggaaac gtcgccacct tctggtaagt      240

gatggaaatg agcaggaaaa aagatccaag ctaagaagcg gctttttttt ttttccaaag      300

cagcaagcca cgcccctccc gcgctcgcga aatccgagac ccgccctttc cggaagtttt      360

gacactgtgc gccccgagt                                                   379


<210>  37
<211>  564
<212>  DNA
<213>  Homo sapiens

<400>  37
agatagaggt atatacactt actcagacat atatatataa attctgaggt tcactgacca       60

taaaaagtcc taccatggtt gccaggttaa gaaccctgaa tgtaaggaaa gaaacgaaat      120

taatgtggtt aaagagctga aagctctttg ggtagccgtc aagaatacgt ggagaagaat      180

aggaacgcca gacccagggg ggtccaaggc tggcgtccct agtgccacag tgccctctgg      240

tggtagatca taatcattgc tgcgtactcc caggccagag gaagaaatgt aggactcgga      300

aaatgccgga gtccactctg tctcccctca agcctccaga tttgtacacc catctgtcct      360

tcagtcatct tccccacagc ccatctctta ggaatttgat atctcttaag gcagtgaaat      420

gtttctcaga gtgaggccca aggacagttt actcaacagg tcctcaggta gacagatagt      480

ttcagaggac aaagtgatca acaattttgt tcctctactt ttcacagatc tgaaaaatga      540

cagcgattat ggctgtgaca gaaa                                             564


<210>  38
<211>  592
<212>  DNA
<213>  Homo sapiens

<400>  38
gatatctgac agtgccttgt accccagata gacgtgtgtt tatcaagtca cacagtgact       60

tggagaccgc catagtttta ccctgaccaa gactgtcata gagcttggct tctaacctca      120

gcagaaggct tgctcatgtc catgcactta gtcggtttat tctagtttca cgaagtggag      180

gtttttgatt tctaatctgg cacagatgct ccatcccgtg ccttctccag ggatgttttc      240

tgagatcacc caggttttac caggttttat ggggcgagaa cctgtcctca cttaaaaagt      300

aaggaagtta tgccccctgc aggacaaatc ggtaactgca ggctcggtga tctgcgagga      360

cagtgttctg tgccttttgg agcactatat tgtttctctc cacaatgtgg cgctgctgtt      420

ctaagtgtca ttttagggcc agtttagggt aggaaagagg gtgacagcaa gaattagaag      480

gtgtagggga gggcgccagg gaagtaggga aaggagatgt taggaagaaa gctggtgggc      540

tacttctgcc agatagggct tccctagcac cccaaatctg atccattgca at              592


<210>  39
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  39
agaccagcgc ttctggggga ctccttgcca ttagaacctt cctggggctg attcatggcc       60

aggcctggtc ccccagggga gaacagaacc gacaagtctg aggagcacct atagaccgtg      120

gtcctcccca gcctttagca gggagcccac cagcctgcca gccgccctct ggcgccccgc      180

cgggcctggc ctctacctgc ctctgccccc agcgcccaga aggtggcggc atcgctccac      240

ccacaggagc ccttgccgta cccaagtggg aggttcggct tccttcaccc ctcacttccc      300

actgcatggt tttcctggga gggtgtggtg ggttggggtg gggtgggctg gggcgtgggg      360

agagcagact tccgatgtct a                                                381


<210>  40
<211>  571
<212>  DNA
<213>  Homo sapiens

<400>  40
ctccaccagg agccagggaa caggacccgg gcaggtacag cggtaccacc tgttccttac       60

catgcaaatt tattggtaaa aatgaacttt tttcattgtt cagtttttca aacgataatt      120

tcacttcatc cttctggcat attatgctag tagcaataac tggctagtcc ctacacctgc      180

cttggcggca gcgcatctca cttgtgtgaa aggcctgcac acttcaggtg gatgtagaac      240

aagccctccc gctggaggcg cgatcattca ctgcccccta gtggaccaga tgtgcatgag      300

ccaggatccg tgcttccgct ttgatgtggg ctctgagcaa atcagagctg cattttattt      360

cagtaagttt tcggcctctg ctgctttaat ctttgttgct agtgtctacg gttcttaatt      420

aacagccctg aaatggaata aaatgtcaat caagggtgac tctgtgtaaa gctatattta      480

aatgttaaaa agtcgtgaca ttttcaaaca gtatttcagg cctcatttga tgctcatttt      540

aaaaatcaaa ttttcattag gttataaaaa t                                     571


