                         SEQUENCE LISTING

<110>  ELICERA THERAPEUTICS AB
 
<120>  ANTI-IL13RA2 ANTIBODIES, ANTIGEN-BINDING FRAGMENTS AND USES 
       THEREOF

<130>  HSJ105439P.WOP

<150>  SE 2050572-3
<151>  2020-05-15

<160>  119   

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  1

Ser Gly Ser Tyr 
1               


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  2

Tyr Gly Ser Gly Gly Tyr 
1               5       


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  3

Tyr Ser Pro Phe Tyr 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  4

Gly Tyr Ser Phe Pro 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  5

Ser Gly Ser Tyr Met Ser 
1               5       


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH extended CDR1

<400>  6

Gly Phe Thr Phe Ser Gly Ser Tyr Met Ser 
1               5                   10  


<210>  7
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  7

Ile Tyr Gly Ser Gly Gly Tyr Thr 
1               5               


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH eCDR2

<400>  8

Ser Ile Tyr Gly Ser Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  9

Tyr Ser Pro Phe Tyr Met 
1               5       


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  10

Ala Arg Tyr Ser Pro Phe Tyr Met Asp Tyr 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  11

Gln Gln Gly Tyr Ser Phe Pro Pro Thr 
1               5                   


<210>  12
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  12

Gln Ser Ile Ser Ser Tyr 
1               5       


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ser 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Tyr Gly Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Ser Pro Phe Tyr Met Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  15
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  15

Val Val Arg Ser Thr Tyr Gly Tyr 
1               5               


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  16

Tyr Gly His Tyr Ala Tyr Gly Ser Tyr 
1               5                   


<210>  17
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  17

Tyr Ser Ser Ser Gly Trp Tyr Tyr Gly Phe 
1               5                   10  


<210>  18
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  18

Thr Pro Tyr Ser Ala Tyr 
1               5       


<210>  19
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  19

Arg Tyr Arg Ser His Arg Pro Gly Leu Ser 
1               5                   10  


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  20

Phe His Pro Arg Tyr Gly Tyr 
1               5           


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  21

Gly Ser Tyr Ser His Tyr Gly Ala His Tyr 
1               5                   10  


<210>  22
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  22

Tyr Tyr His Tyr Asp Tyr Gly Tyr Tyr Tyr 
1               5                   10  


<210>  23
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  23

Ser Glu Trp Ser Asp Lys Gln Cys Trp Gly Leu Asn Asp Ile Phe 
1               5                   10                  15  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR part

<400>  24

Arg Asn Tyr Trp Glu His Gly Gly Gly Ser 
1               5                   10  


<210>  25
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  25

His His Tyr Gly Tyr Tyr Pro Pro Gly Ser Val Tyr Tyr 
1               5                   10              


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  26

Val Glu Tyr Thr Tyr Tyr Gly Ser Glu Gly Ser Pro Val 
1               5                   10              


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GS-linker

<400>  27

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  28
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  28

Thr Tyr Tyr Ser Pro His 
1               5       


<210>  29
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  29

Asp Tyr Tyr Leu Phe 
1               5   


<210>  30
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  30

Ser Tyr Ser Thr Pro Tyr 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  31

Phe Tyr Ser Tyr Pro Leu 
1               5       


<210>  32
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  32

Ala Phe Ser Pro Ser 
1               5   


<210>  33
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  33

Ser Tyr Asp Thr Leu Leu 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  34

Ala Leu Ser Ser Leu Pro 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  35

Phe Ser Thr Arg Leu Ser 
1               5       


<210>  36
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  36

Glu Ile Lys Leu Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg 
1               5                   10                  15      


Cys Phe Asp 
            


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  37

Ser Thr Tyr Pro Phe 
1               5   


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  38

Tyr Gly Ser Asn Pro Leu 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 part

<400>  39

Arg Tyr Asn Gly Leu Phe 
1               5       


<210>  40
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  40

Tyr Gly His Tyr Ala Tyr Gly Ser Tyr Phe 
1               5                   10  


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  41

Thr Pro Tyr Ser Ala Tyr Ile 
1               5           


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 part

<400>  42

Gly Ser Tyr Ser His Tyr Gly Ala His Tyr Leu 
1               5                   10      


<210>  43
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  43

Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro Pro Val Tyr 
1               5                   10                  15      


Leu Thr 
        


<210>  44
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  44

Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr Trp 
1               5                   10                  15  


<210>  45
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  45

Asp Leu Asn Lys Gly Ile Glu Ala Lys Ile His 
1               5                   10      


<210>  46
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  46

Trp Ala Glu Thr Thr Tyr 
1               5       


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH extended CDR1

<400>  47

Gly Phe Thr Phe Gly Tyr Tyr Tyr Met Tyr 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH extended CDR1

<400>  48

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH extended CDR1

<400>  49

Gly Phe Thr Phe Tyr Gly Ser Tyr Met Gly 
1               5                   10  


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH extended CDR1

<400>  50

Gly Phe Thr Phe Gly Ser Ser Tyr Met Tyr 
1               5                   10  


<210>  51
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH extended CDR1

<400>  51

Gly Phe Thr Phe Tyr Ser Tyr Gly Met Ser 
1               5                   10  


<210>  52
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH extended CDR1

<400>  52

Gly Phe Thr Phe Ser Ser Tyr Gly Met Ser 
1               5                   10  


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  53

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  54

Ile Ser Gly Gly Gly Ser Tyr Thr 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  55

Ile Ser Gly Tyr Gly Gly Tyr Thr 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  56

Ile Ser Gly Ser Gly Ser Tyr Thr 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  57

Ile Ser Ser Gly Ser Ser Tyr Thr 
1               5               


<210>  58
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH eCDR2

<400>  58

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH eCDR2

<400>  59

Tyr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  60
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH eCDR2

<400>  60

Tyr Ile Ser Gly Tyr Gly Gly Tyr Thr Tyr 
1               5                   10  


<210>  61
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH eCDR2

<400>  61

Gly Ile Ser Gly Ser Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  62
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH eCDR2

<400>  62

Tyr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr 
1               5                   10  


<210>  63
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH eCDR2

<400>  63

Ser Ile Ser Ser Gly Ser Ser Tyr Thr Tyr 
1               5                   10  


<210>  64
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  64

Ala Arg Val Val Arg Ser Thr Tyr Gly Tyr Phe Asp Tyr 
1               5                   10              


<210>  65
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  65

Ala Arg Tyr Gly His Tyr Ala Tyr Gly Ser Tyr Phe Asp Tyr 
1               5                   10                  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  66

Ala Arg Tyr Ser Ser Ser Gly Trp Tyr Tyr Gly Phe Met Asp Tyr 
1               5                   10                  15  


<210>  67
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  67

Ala Arg Thr Pro Tyr Ser Ala Tyr Ile Asp Tyr 
1               5                   10      


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  68

Ala Arg Arg Tyr Arg Ser His Arg Pro Gly Leu Ser Phe Asp Tyr 
1               5                   10                  15  


<210>  69
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  69

Ala Arg Phe His Pro Arg Tyr Gly Tyr Phe Asp Tyr 
1               5                   10          


<210>  70
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  70

Ala Arg Gly Ser Tyr Ser His Tyr Gly Ala His Tyr Leu Asp Tyr 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  71

Ala Arg Tyr Tyr His Tyr Asp Tyr Gly Tyr Tyr Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  72

Ala Arg Arg Asn Tyr Trp Glu His Gly Gly Gly Ser Leu Asp Tyr 
1               5                   10                  15  


<210>  73
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  73

Ala Arg His His Tyr Gly Tyr Tyr Pro Pro Gly Ser Val Tyr Tyr Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  74
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  74

Ala Arg Val Glu Tyr Thr Tyr Tyr Gly Ser Glu Gly Ser Pro Val Phe 
1               5                   10                  15      


Asp Tyr 
        


<210>  75
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  75

Gln Gln Thr Tyr Tyr Ser Pro His Thr 
1               5                   


<210>  76
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  76

Gln Gln Asp Tyr Tyr Leu Phe Thr 
1               5               


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  77

Gln Gln Ser Tyr Ser Thr Pro Tyr Thr 
1               5                   


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  78

Gln Gln Phe Tyr Ser Tyr Pro Leu Thr 
1               5                   


<210>  79
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  79

Gln Gln Ala Phe Ser Pro Ser Thr 
1               5               


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  80

Gln Gln Ser Tyr Asp Thr Leu Leu Thr 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  81

Gln Gln Ala Leu Ser Ser Leu Pro Thr 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  82

Gln Gln Phe Ser Thr Arg Leu Ser Thr 
1               5                   


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  83

Gln Gln Ser Thr Tyr Pro Phe Thr 
1               5               


<210>  84
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  84

Gln Gln Tyr Gly Ser Asn Pro Leu Thr 
1               5                   


<210>  85
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  85

Gln Gln Arg Tyr Asn Gly Leu Phe Thr 
1               5                   


<210>  86
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain

<400>  86

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly His Tyr Ala Tyr Gly Ser Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  87
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain

<400>  87

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Tyr Leu Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  88
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain

<400>  88

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Gly Ser 
            20                  25                  30          


Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Tyr Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Pro Tyr Ser Ala Tyr Ile Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  89
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain

<400>  89

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Tyr Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  90
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH chain

<400>  90

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Tyr Ser His Tyr Gly Ala His Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  91
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL chain

<400>  91

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Leu Ser Ser Leu Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  92
<211>  274
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1E10B9 scFv

<400>  92

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Tyr Cys Lys Ala Ser Gly Tyr Ser Phe Arg Asp Tyr 
            20                  25                  30          


Ser Val His Trp Val Lys Gln Ala Pro Gly Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Glu Thr Gly Glu Pro Thr Tyr Val Asp Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Phe Leu Glu Ala Ser Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Ile Ser Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Asp Tyr Arg Phe Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Ile Val Met Thr Gln Thr Pro Leu Ile Leu Ser Val Thr Ile Gly 
    130                 135                 140                 


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
145                 150                 155                 160 


Asn Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
                165                 170                 175     


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
        195                 200                 205             


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly 
    210                 215                 220                 


Ser His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
225                 230                 235                 240 


Ala Ala Ala Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp 
                245                 250                 255     


Ile Asp Tyr Lys Asp Asp Asp Asp Lys Ala Ala Ala His His His His 
            260                 265                 270         


His His 
        


<210>  93
<211>  279
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mAb47 scFv

<400>  93

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Leu Met Asn Trp Val Lys Gln Arg Pro Glu Gln Asp Leu Asp Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Tyr Asp Gly Asp Ile Asp Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Thr Ala Tyr Gly Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser 
    130                 135                 140                 


Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn Trp Phe Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Arg Gln 
            180                 185                 190         


Gly Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Ser Leu Asn Ile His Pro Met Glu Glu Asp Asp Thr Ala Met Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Ser Lys Glu Val Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Glu Ile Lys Ala Ala Ala Asp Tyr Lys Asp His Asp Gly Asp 
                245                 250                 255     


Tyr Lys Asp His Asp Ile Asp Tyr Lys Asp Asp Asp Asp Lys Ala Ala 
            260                 265                 270         


Ala His His His His His His 
        275                 


<210>  94
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  94

Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
1               5                   10                  


<210>  95
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  95

Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
1               5                   10          


<210>  96
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
1               5                   10  


<210>  97
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  97

Asp Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu 
1               5                   10                  


<210>  98
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  98

Ala Lys Ile His Thr Leu Leu 
1               5           


<210>  99
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  99

Phe Thr Phe Gln Leu 
1               5   


<210>  100
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  100

Gly Phe Thr Phe Gly Tyr Tyr Tyr 
1               5               


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  101

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  102
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  102

Gly Phe Thr Phe Tyr Gly Ser Tyr 
1               5               


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  103

Gly Phe Thr Phe Gly Ser Ser Tyr 
1               5               


<210>  104
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  104

Gly Phe Thr Phe Tyr Ser Tyr Gly 
1               5               


<210>  105
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  105

Gly Phe Thr Phe Ser Gly Ser Tyr 
1               5               


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  106

Gly Phe Thr Phe Ser Ser Tyr Gly 
1               5               


<210>  107
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ala Phe Val Cys Leu Ala Ile Gly Cys Leu Tyr Thr Phe Leu Ile 
1               5                   10                  15      


Ser Thr Thr Phe Gly Cys Thr Ser Ser Ser Asp Thr Glu Ile Lys Val 
            20                  25                  30          


Asn Pro Pro Gln Asp Phe Glu Ile Val Asp Pro Gly Tyr Leu Gly Tyr 
        35                  40                  45              


Leu Tyr Leu Gln Trp Gln Pro Pro Leu Ser Leu Asp His Phe Lys Glu 
    50                  55                  60                  


Cys Thr Val Glu Tyr Glu Leu Lys Tyr Arg Asn Ile Gly Ser Glu Thr 
65                  70                  75                  80  


Trp Lys Thr Ile Ile Thr Lys Asn Leu His Tyr Lys Asp Gly Phe Asp 
                85                  90                  95      


Leu Asn Lys Gly Ile Glu Ala Lys Ile His Thr Leu Leu Pro Trp Gln 
            100                 105                 110         


Cys Thr Asn Gly Ser Glu Val Gln Ser Ser Trp Ala Glu Thr Thr Tyr 
        115                 120                 125             


Trp Ile Ser Pro Gln Gly Ile Pro Glu Thr Lys Val Gln Asp Met Asp 
    130                 135                 140                 


Cys Val Tyr Tyr Asn Trp Gln Tyr Leu Leu Cys Ser Trp Lys Pro Gly 
145                 150                 155                 160 


Ile Gly Val Leu Leu Asp Thr Asn Tyr Asn Leu Phe Tyr Trp Tyr Glu 
                165                 170                 175     


Gly Leu Asp His Ala Leu Gln Cys Val Asp Tyr Ile Lys Ala Asp Gly 
            180                 185                 190         


Gln Asn Ile Gly Cys Arg Phe Pro Tyr Leu Glu Ala Ser Asp Tyr Lys 
        195                 200                 205             


Asp Phe Tyr Ile Cys Val Asn Gly Ser Ser Glu Asn Lys Pro Ile Arg 
    210                 215                 220                 


Ser Ser Tyr Phe Thr Phe Gln Leu Gln Asn Ile Val Lys Pro Leu Pro 
225                 230                 235                 240 


Pro Val Tyr Leu Thr Phe Thr Arg Glu Ser Ser Cys Glu Ile Lys Leu 
                245                 250                 255     


Lys Trp Ser Ile Pro Leu Gly Pro Ile Pro Ala Arg Cys Phe Asp Tyr 
            260                 265                 270         


Glu Ile Glu Ile Arg Glu Asp Asp Thr Thr Leu Val Thr Ala Thr Val 
        275                 280                 285             


Glu Asn Glu Thr Tyr Thr Leu Lys Thr Thr Asn Glu Thr Arg Gln Leu 
    290                 295                 300                 


Cys Phe Val Val Arg Ser Lys Val Asn Ile Tyr Cys Ser Asp Asp Gly 
305                 310                 315                 320 


Ile Trp Ser Glu Trp Ser Asp Lys Gln Cys Trp Glu Gly Glu Asp Leu 
                325                 330                 335     


Ser Lys Lys Thr Leu Leu Arg Phe Trp Leu Pro Phe Gly Phe Ile Leu 
            340                 345                 350         


Ile Leu Val Ile Phe Val Thr Gly Leu Leu Leu Arg Lys Pro Asn Thr 
        355                 360                 365             


Tyr Pro Lys Met Ile Pro Glu Phe Phe Cys Asp Thr 
    370                 375                 380 


<210>  108
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  108

Glu Tyr Glu Leu Lys Tyr Arg Asn 
1               5               


<210>  109
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  109

Ile Glu Ala Lys Ile His Thr Leu Leu 
1               5                   


<210>  110
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  110

Ala Glu Thr Thr Tyr 
1               5   


<210>  111
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal with Avi-tag and His6-tag

<400>  111

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu His 
1               5                   10                  15      


His His His His His 
            20      


<210>  112
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR1 region

<400>  112

Phe Tyr Gly Ser Tyr Met Gly Trp 
1               5               


<210>  113
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR2 region

<400>  113

Ser Tyr Ile Ser Gly Tyr Gly 
1               5           


<210>  114
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR3 region

<400>  114

Arg Thr Pro Tyr Ser Ala Tyr Ile Asp 
1               5                   


<210>  115
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light CDR3 region

<400>  115

Gln Phe Tyr Ser Tyr Pro Leu Thr 
1               5               


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR1 region

<400>  116

Phe Ala Gly Ser Tyr Met Ala Trp 
1               5               


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR2 region

<400>  117

Ser Ala Ile Ala Gly Ala Gly 
1               5           


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy CDR3 region

<400>  118

Arg Ala Ala Ala Ala Ala Tyr Ala Asp 
1               5                   


<210>  119
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light CDR3 region

<400>  119

Gln Ala Tyr Ser Ala Pro Ala Thr 
1               5               


