                         SEQUENCE LISTING

<110>  Yeda Research and Development Co. Ltd.
       The Walter and Eliza Hall Institute of Medical Research
       FLEISHMAN, Sarel
       ELAZAR, Assaf
       WEINSTEIN, Jonathan Y.
       CALL, Melissa J.
       CALL, Matthew E.
       CHANDLER, Nicholas J.
 
<120>  DE-NOVO DESIGNED TRANSMEMBRANE POLYPEPTIDES AND THEIR USES IN 
       CELLULAR IMMUNOTHERAPY

<130>  87815

<150>  IL 274696
<151>  2020-05-14

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  1

Pro Leu Ser Phe Leu Leu Gly Ile Leu Ala Ala Leu Val Gly Phe Ile 
1               5                   10                  15      


Ile Gly Phe Leu Ala Ala Leu Ile 
            20                  


<210>  2
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  2

Pro Leu Leu Phe Ile Leu Val Ala Ile Leu Gly Gly Leu Phe Gly Ala 
1               5                   10                  15      


Ile Val Ala Phe Leu Leu Ala Leu 
            20                  


<210>  3
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  3

Pro Ile Leu Phe Ala Ile Leu Ala Ala Phe Ile Gly Ala Phe Ile Ala 
1               5                   10                  15      


Ala Leu Phe Val Leu Val Leu Ala 
            20                  


<210>  4
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  4

Pro Phe Gly Ala Leu Leu Ala Ile Ile Ala Phe Val Val Gly Met Leu 
1               5                   10                  15      


Phe Ser Ala Phe Val Leu Leu Ile 
            20                  


<210>  5
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  5

Pro Phe Ser Leu Phe Leu Gly Val Ile Ala Gly Ile Ile Ala Ala Phe 
1               5                   10                  15      


Ile Val Leu Phe Leu Ala Leu Leu 
            20                  


<210>  6
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  6

Pro Phe Leu Ser Leu Val Gly Ala Leu Ile Gly Ala Phe Ile Ala Phe 
1               5                   10                  15      


Ile Leu Ala Leu Phe Ile Leu Val 
            20                  


<210>  7
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  7

Pro Ile Leu Ile Thr Leu Ala Met Leu Thr Gly Ala Val Ile Gly Ala 
1               5                   10                  15      


Ile Ser Ser Phe Leu Leu Val Tyr 
            20                  


<210>  8
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  8

Pro Ala Phe Tyr Ile Ile Leu Ala Ile Leu Thr Ser Phe Ile Ala Tyr 
1               5                   10                  15      


Leu Val Gly Leu Leu Val Ser Phe 
            20                  


<210>  9
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  9

Pro Ile Tyr Val Ile Leu Ala Ile Leu Ala Ala Val Phe Thr Trp Phe 
1               5                   10                  15      


Ile Val Leu Ile Thr Ser Leu Ser 
            20                  


<210>  10
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  10

Pro Thr Val Thr Ser Ala Ile Leu Gly Val Ser Phe Gly Thr Phe Ile 
1               5                   10                  15      


Ser Leu Val Ala Leu Trp Leu Ala 
            20                  


<210>  11
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  11

Pro Val Ile Ala Ile Leu Thr Phe Ile Val Leu Thr Ala Ile Ser Gly 
1               5                   10                  15      


Ala Leu Leu Ala Val Trp Phe Ser 
            20                  


<210>  12
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  12

Pro Ile Val Leu Leu Leu Ser Leu Leu Ala Ser Val Phe Gly Ala Phe 
1               5                   10                  15      


Ile Thr Phe Ile Trp Ala Tyr Leu 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  13

Pro Leu Thr Val Ala Leu Ile Leu Gly Ile Phe Leu Gly Thr Phe Ile 
1               5                   10                  15      


Ala Phe Trp Val Val Tyr Leu Leu 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  14

Thr Ala Leu Leu Val Ala Phe Val Ala Tyr Tyr Thr Ala Leu Ile Ala 
1               5                   10                  15      


Leu Ile Phe Ala Ile Leu Ala Thr 
            20                  


<210>  15
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  15
cctttatctt tcctcttagg gatactagct gcgctggtgg ggttcatcat tggcttttta       60

gcggccttga tt                                                           72


<210>  16
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  16
cctttgttat ttattctcgt cgcaatactt ggaggcttat ttggggcgat tgttgcattc       60

cttttggcgt ta                                                           72


<210>  17
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  17
ccgatcctgt tcgcaatact ggcggctttc atcggggcat ttatagctgc cctgttcgtg       60

ctagtattgg ca                                                           72


<210>  18
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  18
ccctttggag ctttactagc aatcatagca ttcgtcgtag gaatgttatt ctcagcattc       60

gttttactca tc                                                           72


<210>  19
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  19
ccctttagct tgtttttggg cgttatagcc ggcattattg ctgcattcat cgttttattc       60

ctggcattac ta                                                           72


<210>  20
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  20
ccttttttat cgcttgttgg tgcgctaatc ggggctttca tagcatttat cttggctttg       60

ttcattttgg tt                                                           72


<210>  21
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  21
ccgattctga tcactttggc aatgcttacg ggagcagtga ttggggcgat ctcgtctttt       60

ctcctagtgt at                                                           72


<210>  22
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  22
ccagcctttt atattatatt ggcaattctc acctcgttca tagcctattt ggtgggtcta       60

ctcgtgtctt tt                                                           72


<210>  23
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  23
cctatttacg ttatactagc catcttggcc gcggtattca cttggttcat agtccttata       60

actagcctga gt                                                           72


<210>  24
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  24
cctacggtta cgagtgcgat tcttggcgtg tcattcggta cctttattag cctcgtagct       60

ctgtggcttg ca                                                           72


<210>  25
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  25
ccagtgattg caatcttaac ttttatagtc ctcactgcga tttcgggagc gctgctcgct       60

gtttggttct cc                                                           72


<210>  26
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  26
cccatcgtct tgctcctcag tctactcgcc agtgtatttg gggcgttcat cacatttatt       60

tgggcttact tg                                                           72


<210>  27
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  27
ctggtgctga ttctgctgac ctttgtgctg tttgtgttta ttctgtattg ggtgattacc       60

tggtatctga tt                                                           72


<210>  28
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  28
ccgctgaccg tggcgctgat tctgggcatc ttcctgggca cctttattgc gttttgggtg       60

gtgtatctgc tg                                                           72


<210>  29
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs

<400>  29
accgcgctgc tggtggcgtt tgtggcgtat tataccgcgc tgattgcgct gatttttgcg       60

attctggcga cc                                                           72


<210>  30
<211>  71
<212>  DNA
<213>  Artificial sequence

<220>
<223>  monomeric C-terminal portion of human L-selectin (CLS)

<400>  30
ccgctgttca tcccggttgc agttatggtt accgctttta gtggattggg gtttatcatc       60

tggctggcta c                                                            71


<210>  31
<211>  68
<212>  DNA
<213>  Artificial sequence

<220>
<223>  ErbB2 (erb-b2 receptor tyrosine kinase 2)

<400>  31
tctatcatct ctgcggtggt tggcattctg ctggtcgtgg tcttgggcgt ggtctttggc       60

atcctgat                                                                68


<210>  32
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  QSOX2 (quiescin sulfhydryl oxidase 2)

<400>  32
agcctatgcg ttgttttata cgtggcatct agtttattta tggtcatgta cttcttc          57


<210>  33
<211>  3
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid sequence added to the amino terminus of designed 
       sequences

<400>  33

Glu Pro Glu 
1           


<210>  34
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  amino acid sequence added to the carboxy terminus of designed 
       sequences

<400>  34

Arg Arg Leu Cys 
1               


<210>  35
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  designed TMD amino acid sequence

<400>  35

Leu Leu Phe Ile Leu Val Ala Ile Leu Gly Gly Leu Phe Gly Ala Ile 
1               5                   10                  15      


Val Ala Phe Leu Leu Ala Leu 
            20              


<210>  36
<211>  23
<212>  PRT
<213>  Artificial sequence

<220>
<223>  designed TMD amino acid sequence

<400>  36

Leu Thr Val Ala Leu Ile Leu Gly Ile Phe Leu Gly Thr Phe Ile Ala 
1               5                   10                  15      


Phe Trp Val Val Tyr Leu Leu 
            20              


<210>  37
<211>  1512
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding for ProCAR-2 DNA sequence, based on proMP C2.1

<400>  37
atgtctagac aggtacaact gcagcagtca ggacctgaac tgaagaagcc tggagagaca       60

gtcaagatct cctgcaaggc ctctgggtat cctttcacaa actatggaat gaactgggtg      120

aagcaggctc caggacaggg tttaaagtgg atgggctgga ttaacacctc cactggagag      180

tcaacatttg ctgatgactt caagggacgg tttgacttct ctttggaaac ctctgccaac      240

actgcctatt tgcagatcaa caacctcaaa agtgaagaca tggctacata tttctgtgca      300

agatgggagg tttaccacgg ctacgttcct tactggggcc aagggaccac ggtcaccgtt      360

tcctctggcg gtggcggttc tggtggcggt ggctccggcg gtggcggttc tgacatccag      420

ctgacccagt ctcacaaatt cctgtccact tcagtaggag acagggtcag catcacctgc      480

aaggccagtc aggatgtgta taatgctgtt gcctggtatc aacagaaacc aggacaatct      540

cctaaacttc tgatttactc ggcatcctcc cggtacactg gagtcccttc tcgcttcact      600

ggcagtggct ctgggccgga tttcactttc accatcagca gtgtgcaggc tgaagacctg      660

gcagtttatt tctgtcagca acattttcgt actccattca cgttcggctc ggggacaaaa      720

ttggagatcg aacaaaaact catctcagaa gaggatctga atggggtcac cgtctcttca      780

gcgctgagca actccatcat gtacttcagc cacttcgtgc cggtcttcct gccagcgaag      840

cccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      900

ctgtccctgc gcccagaggc ggcccggcca gcggcggggg gcgcagtgca cacgaggggg      960

ctcgatccct tttggctgac tgtggccctt attcttggga tattcttagg aacattcata     1020

gcattttggg tcgtttactt gttatgggtg aggagtaaga ggagcaggct cctgcacagt     1080

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     1140

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1500

ccccctcgct aa                                                         1512


<210>  38
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Coding for ProCAR-2 amino acid sequence based on proMP C2.1

<400>  38

Met Ser Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys 
1               5                   10                  15      


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe 
            20                  25                  30          


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Lys Trp Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala 
    50                  55                  60                  


Asp Asp Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met Ala Thr 
                85                  90                  95      


Tyr Phe Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


His Lys Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe 
    210                 215                 220                 


Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Val 
                245                 250                 255     


Thr Val Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Ala Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Pro Phe Trp Leu Thr Val Ala Leu Ile Leu Gly Ile Phe Leu 
                325                 330                 335     


Gly Thr Phe Ile Ala Phe Trp Val Val Tyr Leu Leu Trp Val Arg Ser 
            340                 345                 350         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        355                 360                 365             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    370                 375                 380                 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  39
<211>  1512
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding for ProCAR-3 DNA sequence based on proMP 1.2

<400>  39
atgtctagac aggtacaact gcagcagtca ggacctgaac tgaagaagcc tggagagaca       60

gtcaagatct cctgcaaggc ctctgggtat cctttcacaa actatggaat gaactgggtg      120

aagcaggctc caggacaggg tttaaagtgg atgggctgga ttaacacctc cactggagag      180

tcaacatttg ctgatgactt caagggacgg tttgacttct ctttggaaac ctctgccaac      240

actgcctatt tgcagatcaa caacctcaaa agtgaagaca tggctacata tttctgtgca      300

agatgggagg tttaccacgg ctacgttcct tactggggcc aagggaccac ggtcaccgtt      360

tcctctggcg gtggcggttc tggtggcggt ggctccggcg gtggcggttc tgacatccag      420

ctgacccagt ctcacaaatt cctgtccact tcagtaggag acagggtcag catcacctgc      480

aaggccagtc aggatgtgta taatgctgtt gcctggtatc aacagaaacc aggacaatct      540

cctaaacttc tgatttactc ggcatcctcc cggtacactg gagtcccttc tcgcttcact      600

ggcagtggct ctgggccgga tttcactttc accatcagca gtgtgcaggc tgaagacctg      660

gcagtttatt tctgtcagca acattttcgt actccattca cgttcggctc ggggacaaaa      720

ttggagatcg aacaaaaact catctcagaa gaggatctga atggggtcac cgtctcttca      780

gcgctgagca actccatcat gtacttcagc cacttcgtgc cggtcttcct gccagcgaag      840

cccaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      900

ctgtccctgc gcccagaggc ggcccggcca gcggcggggg gcgcagtgca cacgaggggg      960

ctcgatccct tttggctgtt gttcatcctg gtggccattt tgggtggact tttcggagct     1020

atagtcgcat ttctcttggc cctatgggtg aggagtaaga ggagcaggct cctgcacagt     1080

gactacatga acatgactcc ccgccgcccc gggcccaccc gcaagcatta ccagccctat     1140

gccccaccac gcgacttcgc agcctatcgc tccagagtga agttcagcag gagcgcagac     1200

gcccccgcgt accagcaggg ccagaaccag ctctataacg agctcaatct aggacgaaga     1260

gaggagtacg atgttttgga caagagacgt ggccgggacc ctgagatggg gggaaagccg     1320

agaaggaaga accctcagga aggcctgtac aatgaactgc agaaagataa gatggcggag     1380

gcctacagtg agattgggat gaaaggcgag cgccggaggg gcaaggggca cgatggcctt     1440

taccagggtc tcagtacagc caccaaggac acctacgacg cccttcacat gcaggccctg     1500

ccccctcgct aa                                                         1512


<210>  40
<211>  503
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ProCAR-3 amino acid sequence based on proMP 1.2

<400>  40

Met Ser Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Lys Lys 
1               5                   10                  15      


Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Pro Phe 
            20                  25                  30          


Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln Gly Leu 
        35                  40                  45              


Lys Trp Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr Phe Ala 
    50                  55                  60                  


Asp Asp Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser Ala Asn 
65                  70                  75                  80  


Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met Ala Thr 
                85                  90                  95      


Tyr Phe Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr Gln Ser 
    130                 135                 140                 


His Lys Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Phe 
    210                 215                 220                 


Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn Gly Val 
                245                 250                 255     


Thr Val Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser His Phe 
            260                 265                 270         


Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala Pro Arg 
        275                 280                 285             


Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg 
    290                 295                 300                 


Pro Glu Ala Ala Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly 
305                 310                 315                 320 


Leu Asp Pro Phe Trp Leu Leu Phe Ile Leu Val Ala Ile Leu Gly Gly 
                325                 330                 335     


Leu Phe Gly Ala Ile Val Ala Phe Leu Leu Ala Leu Trp Val Arg Ser 
            340                 345                 350         


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
        355                 360                 365             


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
    370                 375                 380                 


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
385                 390                 395                 400 


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                405                 410                 415     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            420                 425                 430         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        435                 440                 445             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    450                 455                 460                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
465                 470                 475                 480 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                485                 490                 495     


Met Gln Ala Leu Pro Pro Arg 
            500             


<210>  41
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid coding for SEQ ID No. 35

<400>  41
ttgttattta ttctcgtcgc aatacttgga ggcttatttg gggcgattgt tgcattcctt       60

ttggcgtta                                                               69


<210>  42
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  nucleic acid coding for SEQ ID No. 36

<400>  42
ctgaccgtgg cgctgattct gggcatcttc ctgggcacct ttattgcgtt ttgggtggtg       60

tatctgctg                                                               69


<210>  43
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be S/A/F/G/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be F/A/G/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be A/F/L/M/S/T

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be A/F/I/L/T/V

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<400>  43

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  44
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be A/S

<400>  44

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


<210>  45
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be F/A/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be V/A/I/L/M/T

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be G/A/M/S

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be A/F/I/M/S

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be F/I/L/M

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be A/M/S/T/V

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<400>  45

Xaa Xaa Xaa Xaa Ile Xaa Xaa Ala Ile Xaa Gly Xaa Xaa Xaa Gly Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be G/A/M/S

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be A/S

<400>  46

Ile Xaa Xaa Ala Ile Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15  


<210>  47
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be F/A/G/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be A/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be A/M/S

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be A/M/S/T

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be A/F/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be F/I/L/M/V

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be V/A/F/I/L/M/T

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be A/F/I/L/M/S/T/V

<400>  47

Xaa Xaa Xaa Xaa Xaa Ile Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  48
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be A/M/S

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be A/M/S/T

<400>  48

Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      


<210>  49
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be PL/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be A/F/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be A/M/S

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be M/A/F/I/L/S/V

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be S/A/F/M/T

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be A/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<400>  49

Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  50
<211>  20
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be A/M/S

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be S/A/F/M/T

<220>
<221>  misc_feature
<222>  (17)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be L/I

<400>  50

Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa 
            20  


<210>  51
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be S/A/F/G/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be L/A/I/M/T/V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/I/V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be G/A/F/L/M/S

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be A/F/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be G/A/F/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (12)..(13)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be A/F/M/S/T

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be A/F/L/M/S

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be V/A/F/I/L/M/T

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be L/I/V

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be A/F/I/M/S/T/V

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<400>  51

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  52
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be L/I/V

<220>
<221>  misc_feature
<222>  (2)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  Xaa can be A/F/M/S/T

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be L/I/V

<400>  52

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  


<210>  53
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be L/A/M/S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be S/A/F/G/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be A/F/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be A/F/S

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be A/T/V

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be L/F/I

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<400>  53

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Ala Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  54
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be L/A/M/S

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be A/F/S

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be A/T/V

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be L/F/I

<400>  54

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa 
            20      


<210>  55
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be I/L

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be A/F/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be A/M/S

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be A/F/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be S/A/F/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(22)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be V/A/F/I/L/M/S/T

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be Y/L/I/V/M/S/T/W/F

<400>  55

Xaa Xaa Xaa Xaa Thr Xaa Xaa Met Xaa Thr Xaa Xaa Xaa Xaa Gly Xaa 
1               5                   10                  15      


Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  56
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be I/L

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be A/M/S

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  Xaa can be any naturally occurring amino acid

<400>  56

Xaa Thr Xaa Xaa Met Xaa Thr Xaa Xaa Xaa Xaa Gly Xaa Xaa Ser 
1               5                   10                  15  


<210>  57
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be A/F/L/M/S/T

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be I/L/T/V

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be A/I/M/S/T/V

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be I/F/L

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be T/A/F/G/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be S/A/F/G/L/M/T

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be A/F/I/L/M

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be V/A/F/I/L/M/S/T

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be S/A/F/L/M/T/V

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<400>  57

Xaa Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Ile Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  58
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be I/L/T/V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be I/F/L

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (14)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be L/I

<400>  58

Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Ile Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa 
            


<210>  59
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be I/A/G/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be A/F/M/S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be V/A/F/I/L/M/T

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be A/F/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be A/S/T

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be A/F/I/M/S/T/V

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be T/A/F/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be A/F/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be V/A/F/I/L/M

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be T/A/F/G/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be S/A/F/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be S/L/I/V/F/M/S/T/W/Y

<400>  59

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  60
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be A/F/M/S

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (5)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be A/S/T

<400>  60

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  61
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be T/A/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be S/A/F/L/V

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be A/F/L/M/S/T

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be V/A/F/I/L/M/S/T

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be S/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be T/A/F/G/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be I/F/L/V

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be S/A/G/L/M/T/V

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be V/A/F/I/L/M/S

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be W/L/I/V/F/M/S/T/Y

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be A/G/S

<400>  61

Xaa Xaa Xaa Thr Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
            20                  


<210>  62
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be S/A/F/L/V

<220>
<221>  misc_feature
<222>  (3)..(5)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be I/F/L/V

<220>
<221>  misc_feature
<222>  (14)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be A/G/S

<400>  62

Thr Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Ala Xaa Xaa Xaa Xaa 
            20      


<210>  63
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be A/L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be T/I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be F/I/L/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be I/F/L

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be T/A/F/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be A/F/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be S/I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be A/F/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be V/I/L/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be W/V/I/L/F/M/S/T//Y

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be S/A/F/I/L/M/T/V

<400>  63

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Val Leu Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
            20                  


<210>  64
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be I/F/L

<220>
<221>  misc_feature
<222>  (4)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be G/A

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  64

Xaa Val Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala 
1               5                   10          


<210>  65
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be V/A/F/G/I/L/M/S/T

<220>
<221>  misc_feature
<222>  (4)..(6)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be S/A/F/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be A/F/M/S

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be S/A/F/G/I/L/M/T/V

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be G/A/F/L/M/S

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be A/F/I/M/S/V

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be I/F/L/M

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be T/A/F/I/M/S/V

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be W/I/L/V/F/M/S/T/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be A/T/V

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be A/F/G/I/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<400>  65

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  66
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be A/F/M/S

<220>
<221>  misc_feature
<222>  (2)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be G/A/F/L/M/S

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be A/F/I/M/S/V

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be I/F/L/M

<220>
<221>  misc_feature
<222>  (9)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be A/T/V

<400>  66

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  67
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be P/I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be T/A/F/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be A/F/S

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be I/A/M/T/V

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be T/A/F/G/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be I/L/V/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be A/S/V

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be F/L/I/V/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be W/F/L/I/V/M/S/T/Y

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be V/L/I/F/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be V/A/F/I/L/M/S/T

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be Y/F/L/I/V/M/S/T/W

<220>
<221>  misc_feature
<222>  (23)..(24)
<223>  Xaa can be L/I/V/F/M/S/T/W/Y

<400>  67

Xaa Xaa Xaa Xaa Xaa Xaa Ile Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  68
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be A/F/S

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be I/A/M/T/V

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (10)..(12)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be A/S/V

<400>  68

Xaa Xaa Ile Xaa Gly Xaa Xaa Xaa Gly Xaa Xaa Xaa Xaa 
1               5                   10              


<210>  69
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be T/A/F/G/I/L/M/S/V

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be A/G/S

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be L/A/F/I/M/S/T/V/W

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be V/A/F/I/L/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be F/A/I/K/L/M/R/V

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be V/A/F/I/L/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be Y/A/F/I/K/L/M/S/T/V/W

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be Y/A/F/G/I/L/M/S/T/V/W

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be T/A//F/I/L/M/S/V/W/Y

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be L/I/V

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be I/A/F/L/M/T/V

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be A/G

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be L/F

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be I/F/L/M/V/W

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be F/A/I/L/M/S/T/V/W/Y

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be I/A/L/M/S/V

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be L/A/I/W

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be T/A/F/G/I/L/M//V/W/Y

<400>  69

Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Ala Xaa Xaa Xaa Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
            20                  


<210>  70
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  programmed membrane proteins proMPs


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be A/G/S

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be L/I

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be L/I/V

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be A/G

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be L/F

<220>
<221>  misc_feature
<222>  (17)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be A/S

<400>  70

Xaa Xaa Xaa Xaa Ala Xaa Xaa Ala Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Xaa 
            20          


<210>  71
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  proMP C4.1amino acid sequence

<400>  71

Pro Leu Leu Val Ala Leu Leu Ala Leu Leu Ala Val Ile Ala Ala Leu 
1               5                   10                  15      


Leu Ala Ala Ile Phe Ala Leu Leu 
            20                  


<210>  72
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  proMP C4.1 motif Motif 15


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be A/G/S

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be  A/G/S

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be A/G/S

<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be A/S

<400>  72

Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210>  73
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Sequence space for proMP C4.1


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be L/A/F/G/H/I/M/S/T/V/W/Y

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be L/A/I/T/V

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be V/A/I/L/M/S/T

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be A/G/I/L/M/S/T/V/W

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be L/F/I/M/T/V

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be A/G/S

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be L/A/F/I/M

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be L/I/M/V

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be A/G/S

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa can be V/A/F/G/H/L/M/S/T/W/Y

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be I/F/L/V

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be A/F/G/L/M/S/W/Y

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be A/G/S

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be L/F/I/V

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be L/F/I

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be A/L/M/S/T/V

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be I/F/L/V

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be F/A/H/L/W/Y

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be A/S

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be L/A/F/M/W

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be L/A/I/M/S/W

<400>  73

Pro Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  


<210>  74
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  proMP C4.1 nucleic acid sequence

<400>  74
ccccttctcg tagcattgct ggcccttctg gccgtcatag ctgccctgct ggccgcaatt       60

tttgccctgc tc                                                           72


<210>  75
<211>  66
<212>  DNA
<213>  Artificial sequence

<220>
<223>  new sequence for proMPC4.1 (used in proCAR-4), which is seq ID 15
       with the first and last amino acids deleted

<400>  75
cttctcgtag cattgctggc ccttctggcc gtcatagctg ccctgctggc cgcaattttt       60

gccctg                                                                  66


<210>  76
<211>  1563
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Coding for ProCAR-4 DNA sequence based on proMP C4.1

<400>  76
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cataatgtct       60

agacaggtac aactgcagca gtcaggacct gaactgaaga agcctggaga gacagtcaag      120

atctcctgca aggcctctgg gtatcctttc acaaactatg gaatgaactg ggtgaagcag      180

gctccaggac agggtttaaa gtggatgggc tggattaaca cctccactgg agagtcaaca      240

tttgctgatg acttcaaggg acggtttgac ttctctttgg aaacctctgc caacactgcc      300

tatttgcaga tcaacaacct caaaagtgaa gacatggcta catatttctg tgcaagatgg      360

gaggtttacc acggctacgt tccttactgg ggccaaggga ccacggtcac cgtttcctct      420

ggcggtggcg gttctggtgg cggtggctcc ggcggtggcg gttctgacat ccagctgacc      480

cagtctcaca aattcctgtc cacttcagta ggagacaggg tcagcatcac ctgcaaggcc      540

agtcaggatg tgtataatgc tgttgcctgg tatcaacaga aaccaggaca atctcctaaa      600

cttctgattt actcggcatc ctcccggtac actggagtcc cttctcgctt cactggcagt      660

ggctctgggc cggatttcac tttcaccatc agcagtgtgc aggctgaaga cctggcagtt      720

tatttctgtc agcaacattt tcgtactcca ttcacgttcg gctcggggac aaaattggag      780

atcgaacaaa aactcatctc agaagaggat ctgaatgggg tcaccgtctc ttcagcgctg      840

agcaactcca tcatgtactt cagccacttc gtgccggtct tcctgccagc gaagcccacc      900

acgacgccag cgccgcgacc accaacaccg gcgcccacca tcgcgtcgca gcccctgtcc      960

ctgcgcccag aggcggcccg gccagcggcg gggggcgcag tgcacacgag ggggctcgat     1020

cccttttggc ttctcgtagc attgctggcc cttctggccg tcatagctgc cctgctggcc     1080

gcaatttttg ccctgtgggt gaggagtaag aggagcaggc tcctgcacag tgactacatg     1140

aacatgactc cccgccgccc cgggcccacc cgcaagcatt accagcccta tgccccacca     1200

cgcgacttcg cagcctatcg ctccagagtg aagttcagca ggagcgcaga cgcccccgcg     1260

taccagcagg gccagaacca gctctataac gagctcaatc taggacgaag agaggagtac     1320

gatgttttgg acaagagacg tggccgggac cctgagatgg ggggaaagcc gagaaggaag     1380

aaccctcagg aaggcctgta caatgaactg cagaaagata agatggcgga ggcctacagt     1440

gagattggga tgaaaggcga gcgccggagg ggcaaggggc acgatggcct ttaccagggt     1500

ctcagtacag ccaccaagga cacctacgac gcccttcaca tgcaggccct gccccctcgc     1560

taa                                                                   1563


<210>  77
<211>  520
<212>  PRT
<213>  Artificial sequence

<220>
<223>  ProCAR-4 amino acid sequence based on proMP C4.1

<400>  77

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Pro Phe Thr Asn Tyr Gly Met Asn Trp Val Lys Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr Ser Thr Gly Glu Ser Thr 
65                  70                  75                  80  


Phe Ala Asp Asp Phe Lys Gly Arg Phe Asp Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Asn Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Ser Glu Asp Met 
            100                 105                 110         


Ala Thr Tyr Phe Cys Ala Arg Trp Glu Val Tyr His Gly Tyr Val Pro 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Leu Thr 
145                 150                 155                 160 


Gln Ser His Lys Phe Leu Ser Thr Ser Val Gly Asp Arg Val Ser Ile 
                165                 170                 175     


Thr Cys Lys Ala Ser Gln Asp Val Tyr Asn Ala Val Ala Trp Tyr Gln 
            180                 185                 190         


Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Ser Ala Ser Ser 
        195                 200                 205             


Arg Tyr Thr Gly Val Pro Ser Arg Phe Thr Gly Ser Gly Ser Gly Pro 
    210                 215                 220                 


Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val 
225                 230                 235                 240 


Tyr Phe Cys Gln Gln His Phe Arg Thr Pro Phe Thr Phe Gly Ser Gly 
                245                 250                 255     


Thr Lys Leu Glu Ile Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Asn 
            260                 265                 270         


Gly Val Thr Val Ser Ser Ala Leu Ser Asn Ser Ile Met Tyr Phe Ser 
        275                 280                 285             


His Phe Val Pro Val Phe Leu Pro Ala Lys Pro Thr Thr Thr Pro Ala 
    290                 295                 300                 


Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser 
305                 310                 315                 320 


Leu Arg Pro Glu Ala Ala Arg Pro Ala Ala Gly Gly Ala Val His Thr 
                325                 330                 335     


Arg Gly Leu Asp Pro Phe Trp Leu Leu Val Ala Leu Leu Ala Leu Leu 
            340                 345                 350         


Ala Val Ile Ala Ala Leu Leu Ala Ala Ile Phe Ala Leu Trp Val Arg 
        355                 360                 365             


Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro 
    370                 375                 380                 


Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro 
385                 390                 395                 400 


Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala 
                405                 410                 415     


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
            420                 425                 430         


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
        435                 440                 445             


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
    450                 455                 460                 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
465                 470                 475                 480 


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
                485                 490                 495     


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
            500                 505                 510         


His Met Gln Ala Leu Pro Pro Arg 
        515                 520 


