                         SEQUENCE LISTING

<110>  CRISPR THERAPEUTICS AG
 
<120>  MESSENGER RNA ENCODING CAS9 FOR USE IN GENOME-EDITING SYSTEMS

<130>  33165/CB35

<150>  US 63/025,755
<151>  2020-05-15

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  4506
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1
agaggaaata agagagaaaa gaagagtaag aagaaatata agagccacca tggcccctaa       60

gaagaagaga aaagtcggaa ttcacggagt ccccgccgcc gacaaaaagt actccattgg      120

ccttgatatt ggaaccaact ccgtgggttg ggccgtgatc actgacgagt acaaggtgcc      180

gtccaagaag ttcaaggtgc tggggaacac tgaccggcac tcaattaaga agaacctgat      240

tggggcgctg ctgttcgact ccggagaaac cgcggaggct acccgcctga agcggactgc      300

ccggcggaga tacacgcgca ggaagaaccg gatttgctac ctccaagaaa tcttcagcaa      360

cgaaatggca aaggtggacg attccttctt ccatcgcctg gaagagagct tcctggtgga      420

agaggacaag aagcacgaaa gacacccgat tttcggcaac atcgtggatg aggtcgcata      480

ccacgaaaag taccccacca tctatcatct tcggaagaag ctggtcgact ccaccgataa      540

ggccgatctg cgcctgatct acttggcgct ggctcacatg attaagttca gaggacactt      600

tctgatagag ggcgacctca atcccgataa ctccgacgtg gataagctgt tcatccaact      660

ggtgcagacg tacaaccaac tgtttgaaga gaatccaatc aacgccagcg gggtggacgc      720

caaggccatc ctgtccgccc ggctgtcaaa gtccagacgc ctggagaatc tcatcgcgca      780

actccctggc gaaaaaaaga acggactctt cgggaatctg attgctctgt ccctggggct      840

cactccgaac ttcaagtcga acttcgacct ggcggaggac gctaagctgc agctgtccaa      900

ggacacctac gatgacgatc tggataacct tctggcccag atcggggatc aatacgccga      960

tctcttcctg gccgcaaaga acttgtcgga tgctattctg ctgagcgaca ttctgcgggt     1020

caatactgaa atcaccaagg cgcccctgtc ggccagcatg atcaagcgct acgacgaaca     1080

ccaccaagac ctgactctgc tgaaggccct cgtgcgccag cagctgcctg aaaagtacaa     1140

ggagattttc ttcgaccagt ccaagaacgg atacgccgga tacattgacg gaggggccag     1200

ccaggaggaa ttttacaaat tcatcaagcc cattctcgag aaaatggacg gaaccgaaga     1260

gttgctcgtg aagctgaaca gagaggatct cctccggaag cagcggacct tcgacaacgg     1320

ttccatcccg caccaaatcc acctgggcga attgcacgcc atcctccggc ggcaggaaga     1380

tttctaccca ttcttgaagg acaatcgcga aaagatcgaa aagatcttga ctttccgcat     1440

cccgtactac gtgggccctc tggcccgcgg caactcccgc ttcgcttgga tgacacggaa     1500

gtccgaggaa accattacgc cctggaactt cgaggaagtg gtggacaagg gggcgtccgc     1560

ccagagcttc atcgaacgca tgaccaattt cgacaagaac ctcccgaacg aaaaagtgct     1620

gccaaagcac tcgctcctct acgaatactt caccgtgtac aacgagctga ctaaggtcaa     1680

atacgtgact gagggaatgc ggaagccggc cttcctgtcg ggagagcaga agaaggccat     1740

agtggacttg cttttcaaga ctaaccggaa ggtcactgtg aagcaactca aggaggacta     1800

cttcaagaag atcgagtgtt tcgactcggt ggagatctcg ggtgtcgagg accgcttcaa     1860

cgcctccctg ggaacttacc acgatctgct gaagatcatc aaggacaagg acttcctcga     1920

taacgaagaa aatgaggaca tcctcgagga tatcgtgctg accctgacct tgttcgagga     1980

tagggagatg atcgaggagc ggctcaagac ctacgcccac ctgtttgacg acaaagtgat     2040

gaagcaactg aaacggcgga ggtataccgg ctggggtcgg ctgtcccgca agctgatcaa     2100

cgggatcagg gacaagcagt ccggaaagac catcctcgac ttccttaagt ccgacggatt     2160

cgcgaaccgc aacttcatgc aacttatcca cgacgactcg ctgacattca aggaagatat     2220

ccagaaggcc caggtgtccg gacaggggga ctcgcttcat gagcacatcg ctaacctggc     2280

cggatccccc gccataaaaa agggcattct gcagaccgtc aaagtggtgg atgagctggt     2340

caaggtcatg ggccggcata agccggaaaa catcgtcatc gagatggccc gcgagaacca     2400

gactacgcag aagggccaga agaactcccg ggagcggatg aagcggattg aagagggcat     2460

caaggagctc ggcagccaga ttctgaagga acatcccgtg gaaaacaccc agctgcaaaa     2520

cgaaaagctc tatttgtact atctgcaaaa cggacgcgat atgtacgtgg atcaggagct     2580

ggacattaac agactgagcg actatgacgt ggatcacatt gtgcctcaaa gcttcctcaa     2640

ggacgactca attgacaaca aggtcctgac cagaagcgac aagaacagag gaaagtcgga     2700

taatgtgccg tccgaagaag tggtcaagaa gatgaagaat tactggagac agctcctgaa     2760

tgcgaagctc attacccagc ggaagttcga taacctgacc aaggccgaaa ggggtggact     2820

gtccgaactc gacaaagctg gcttcatcaa gcgccaactg gtcgaaacca ggcagatcac     2880

caagcacgtc gcccagattc tggacagccg catgaacact aagtacgacg agaacgataa     2940

gctgatccgc gaagtgaagg tcatcaccct gaagtccaag ctcgtgtccg actttcggaa     3000

ggatttccag ttttacaagg tccgcgagat caacaactac catcacgccc acgacgcgta     3060

ccttaacgca gtcgtgggaa cggctcttat caagaagtac ccaaagctgg agtcggaatt     3120

tgtgtacgga gactacaaag tgtacgacgt gcgcaagatg atcgccaaat ctgagcaaga     3180

gatcgggaag gcaaccgcca aatacttctt ctactcaaac attatgaatt ttttcaaaac     3240

tgagattacc ctggctaacg gagaaattcg gaagcgcccc ctgattgaaa ccaacggaga     3300

aactggagaa attgtgtggg acaagggacg ggacttcgcc accgtccgca aggtcctctc     3360

aatgccccaa gtcaacatcg tgaaaaagac cgaagtgcaa accggcggct tctcaaagga     3420

gtccatcctg cctaagcgca acagcgacaa gctgattgcc aggaagaagg actgggaccc     3480

gaagaagtac ggaggatttg attcccctac cgtggcctac tccgtgctcg tggtggccaa     3540

agtggaaaag gggaaatcca agaagctgaa gtcggtgaag gagcttttgg gtatcaccat     3600

catggaacgc tcctcgttcg aaaagaaccc aatcgatttc ctggaagcta agggttataa     3660

ggaagtgaaa aaggacctga ttatcaagct gcccaagtac tcactgttcg agctggaaaa     3720

cggtcggaaa aggatgctgg ccagcgccgg agaactccag aagggaaacg aactggcact     3780

gccgtccaaa tacgtcaact tcctctacct tgcatcccat tacgaaaaac tcaagggatc     3840

gccggaggac aacgagcaga agcagctttt cgtggagcaa cacaagcatt acttggacga     3900

gatcatcgag cagatttccg agttctcaaa gcgcgtgatc ctggccgacg caaatctgga     3960

caaggtcctg tccgcgtaca ataagcatcg ggacaagcct atccgcgaac aggccgagaa     4020

catcatccat ctgttcactc tgacaaacct gggcgcaccc gccgcgttca agtactttga     4080

caccaccatc gataggaagc gatacacctc aactaaggaa gtgttggacg cgacccttat     4140

ccatcagtcg atcaccgggc tgtacgaaac acggatcgac ctcagccagt tgggaggcga     4200

caagcgccct gcggctacca agaaggccgg acaggccaag aagaagaaat gagcggccgc     4260

ttaattaagc tgccttctgc ggggcttgcc ttctggccat gcccttcttc tctcccttgc     4320

acctgtacct cttggtcttt gaataaagcc tgagtaggaa gtctagaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4500

aaaaaa                                                                4506


<210>  2
<211>  4506
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2
agaggaaaua agagagaaaa gaagaguaag aagaaauaua agagccacca uggccccuaa       60

gaagaagaga aaagucggaa uucacggagu ccccgccgcc gacaaaaagu acuccauugg      120

ccuugauauu ggaaccaacu ccguggguug ggccgugauc acugacgagu acaaggugcc      180

guccaagaag uucaaggugc uggggaacac ugaccggcac ucaauuaaga agaaccugau      240

uggggcgcug cuguucgacu ccggagaaac cgcggaggcu acccgccuga agcggacugc      300

ccggcggaga uacacgcgca ggaagaaccg gauuugcuac cuccaagaaa ucuucagcaa      360

cgaaauggca aagguggacg auuccuucuu ccaucgccug gaagagagcu uccuggugga      420

agaggacaag aagcacgaaa gacacccgau uuucggcaac aucguggaug aggucgcaua      480

ccacgaaaag uaccccacca ucuaucaucu ucggaagaag cuggucgacu ccaccgauaa      540

ggccgaucug cgccugaucu acuuggcgcu ggcucacaug auuaaguuca gaggacacuu      600

ucugauagag ggcgaccuca aucccgauaa cuccgacgug gauaagcugu ucauccaacu      660

ggugcagacg uacaaccaac uguuugaaga gaauccaauc aacgccagcg ggguggacgc      720

caaggccauc cuguccgccc ggcugucaaa guccagacgc cuggagaauc ucaucgcgca      780

acucccuggc gaaaaaaaga acggacucuu cgggaaucug auugcucugu cccuggggcu      840

cacuccgaac uucaagucga acuucgaccu ggcggaggac gcuaagcugc agcuguccaa      900

ggacaccuac gaugacgauc uggauaaccu ucuggcccag aucggggauc aauacgccga      960

ucucuuccug gccgcaaaga acuugucgga ugcuauucug cugagcgaca uucugcgggu     1020

caauacugaa aucaccaagg cgccccuguc ggccagcaug aucaagcgcu acgacgaaca     1080

ccaccaagac cugacucugc ugaaggcccu cgugcgccag cagcugccug aaaaguacaa     1140

ggagauuuuc uucgaccagu ccaagaacgg auacgccgga uacauugacg gaggggccag     1200

ccaggaggaa uuuuacaaau ucaucaagcc cauucucgag aaaauggacg gaaccgaaga     1260

guugcucgug aagcugaaca gagaggaucu ccuccggaag cagcggaccu ucgacaacgg     1320

uuccaucccg caccaaaucc accugggcga auugcacgcc auccuccggc ggcaggaaga     1380

uuucuaccca uucuugaagg acaaucgcga aaagaucgaa aagaucuuga cuuuccgcau     1440

cccguacuac gugggcccuc uggcccgcgg caacucccgc uucgcuugga ugacacggaa     1500

guccgaggaa accauuacgc ccuggaacuu cgaggaagug guggacaagg gggcguccgc     1560

ccagagcuuc aucgaacgca ugaccaauuu cgacaagaac cucccgaacg aaaaagugcu     1620

gccaaagcac ucgcuccucu acgaauacuu caccguguac aacgagcuga cuaaggucaa     1680

auacgugacu gagggaaugc ggaagccggc cuuccugucg ggagagcaga agaaggccau     1740

aguggacuug cuuuucaaga cuaaccggaa ggucacugug aagcaacuca aggaggacua     1800

cuucaagaag aucgaguguu ucgacucggu ggagaucucg ggugucgagg accgcuucaa     1860

cgccucccug ggaacuuacc acgaucugcu gaagaucauc aaggacaagg acuuccucga     1920

uaacgaagaa aaugaggaca uccucgagga uaucgugcug acccugaccu uguucgagga     1980

uagggagaug aucgaggagc ggcucaagac cuacgcccac cuguuugacg acaaagugau     2040

gaagcaacug aaacggcgga gguauaccgg cuggggucgg cugucccgca agcugaucaa     2100

cgggaucagg gacaagcagu ccggaaagac cauccucgac uuccuuaagu ccgacggauu     2160

cgcgaaccgc aacuucaugc aacuuaucca cgacgacucg cugacauuca aggaagauau     2220

ccagaaggcc cagguguccg gacaggggga cucgcuucau gagcacaucg cuaaccuggc     2280

cggauccccc gccauaaaaa agggcauucu gcagaccguc aaaguggugg augagcuggu     2340

caaggucaug ggccggcaua agccggaaaa caucgucauc gagauggccc gcgagaacca     2400

gacuacgcag aagggccaga agaacucccg ggagcggaug aagcggauug aagagggcau     2460

caaggagcuc ggcagccaga uucugaagga acaucccgug gaaaacaccc agcugcaaaa     2520

cgaaaagcuc uauuuguacu aucugcaaaa cggacgcgau auguacgugg aucaggagcu     2580

ggacauuaac agacugagcg acuaugacgu ggaucacauu gugccucaaa gcuuccucaa     2640

ggacgacuca auugacaaca agguccugac cagaagcgac aagaacagag gaaagucgga     2700

uaaugugccg uccgaagaag uggucaagaa gaugaagaau uacuggagac agcuccugaa     2760

ugcgaagcuc auuacccagc ggaaguucga uaaccugacc aaggccgaaa gggguggacu     2820

guccgaacuc gacaaagcug gcuucaucaa gcgccaacug gucgaaacca ggcagaucac     2880

caagcacguc gcccagauuc uggacagccg caugaacacu aaguacgacg agaacgauaa     2940

gcugauccgc gaagugaagg ucaucacccu gaaguccaag cucguguccg acuuucggaa     3000

ggauuuccag uuuuacaagg uccgcgagau caacaacuac caucacgccc acgacgcgua     3060

ccuuaacgca gucgugggaa cggcucuuau caagaaguac ccaaagcugg agucggaauu     3120

uguguacgga gacuacaaag uguacgacgu gcgcaagaug aucgccaaau cugagcaaga     3180

gaucgggaag gcaaccgcca aauacuucuu cuacucaaac auuaugaauu uuuucaaaac     3240

ugagauuacc cuggcuaacg gagaaauucg gaagcgcccc cugauugaaa ccaacggaga     3300

aacuggagaa auuguguggg acaagggacg ggacuucgcc accguccgca agguccucuc     3360

aaugccccaa gucaacaucg ugaaaaagac cgaagugcaa accggcggcu ucucaaagga     3420

guccauccug ccuaagcgca acagcgacaa gcugauugcc aggaagaagg acugggaccc     3480

gaagaaguac ggaggauuug auuccccuac cguggccuac uccgugcucg ugguggccaa     3540

aguggaaaag gggaaaucca agaagcugaa gucggugaag gagcuuuugg guaucaccau     3600

cauggaacgc uccucguucg aaaagaaccc aaucgauuuc cuggaagcua aggguuauaa     3660

ggaagugaaa aaggaccuga uuaucaagcu gcccaaguac ucacuguucg agcuggaaaa     3720

cggucggaaa aggaugcugg ccagcgccgg agaacuccag aagggaaacg aacuggcacu     3780

gccguccaaa uacgucaacu uccucuaccu ugcaucccau uacgaaaaac ucaagggauc     3840

gccggaggac aacgagcaga agcagcuuuu cguggagcaa cacaagcauu acuuggacga     3900

gaucaucgag cagauuuccg aguucucaaa gcgcgugauc cuggccgacg caaaucugga     3960

caagguccug uccgcguaca auaagcaucg ggacaagccu auccgcgaac aggccgagaa     4020

caucauccau cuguucacuc ugacaaaccu gggcgcaccc gccgcguuca aguacuuuga     4080

caccaccauc gauaggaagc gauacaccuc aacuaaggaa guguuggacg cgacccuuau     4140

ccaucagucg aucaccgggc uguacgaaac acggaucgac cucagccagu ugggaggcga     4200

caagcgcccu gcggcuacca agaaggccgg acaggccaag aagaagaaau gagcggccgc     4260

uuaauuaagc ugccuucugc ggggcuugcc uucuggccau gcccuucuuc ucucccuugc     4320

accuguaccu cuuggucuuu gaauaaagcc ugaguaggaa gucuagaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4500

aaaaaa                                                                4506


<210>  3
<211>  4203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3
atggccccta agaagaagag aaaagtcgga attcacggag tccccgccgc cgacaaaaag       60

tactccattg gccttgatat tggaaccaac tccgtgggtt gggccgtgat cactgacgag      120

tacaaggtgc cgtccaagaa gttcaaggtg ctggggaaca ctgaccggca ctcaattaag      180

aagaacctga ttggggcgct gctgttcgac tccggagaaa ccgcggaggc tacccgcctg      240

aagcggactg cccggcggag atacacgcgc aggaagaacc ggatttgcta cctccaagaa      300

atcttcagca acgaaatggc aaaggtggac gattccttct tccatcgcct ggaagagagc      360

ttcctggtgg aagaggacaa gaagcacgaa agacacccga ttttcggcaa catcgtggat      420

gaggtcgcat accacgaaaa gtaccccacc atctatcatc ttcggaagaa gctggtcgac      480

tccaccgata aggccgatct gcgcctgatc tacttggcgc tggctcacat gattaagttc      540

agaggacact ttctgataga gggcgacctc aatcccgata actccgacgt ggataagctg      600

ttcatccaac tggtgcagac gtacaaccaa ctgtttgaag agaatccaat caacgccagc      660

ggggtggacg ccaaggccat cctgtccgcc cggctgtcaa agtccagacg cctggagaat      720

ctcatcgcgc aactccctgg cgaaaaaaag aacggactct tcgggaatct gattgctctg      780

tccctggggc tcactccgaa cttcaagtcg aacttcgacc tggcggagga cgctaagctg      840

cagctgtcca aggacaccta cgatgacgat ctggataacc ttctggccca gatcggggat      900

caatacgccg atctcttcct ggccgcaaag aacttgtcgg atgctattct gctgagcgac      960

attctgcggg tcaatactga aatcaccaag gcgcccctgt cggccagcat gatcaagcgc     1020

tacgacgaac accaccaaga cctgactctg ctgaaggccc tcgtgcgcca gcagctgcct     1080

gaaaagtaca aggagatttt cttcgaccag tccaagaacg gatacgccgg atacattgac     1140

ggaggggcca gccaggagga attttacaaa ttcatcaagc ccattctcga gaaaatggac     1200

ggaaccgaag agttgctcgt gaagctgaac agagaggatc tcctccggaa gcagcggacc     1260

ttcgacaacg gttccatccc gcaccaaatc cacctgggcg aattgcacgc catcctccgg     1320

cggcaggaag atttctaccc attcttgaag gacaatcgcg aaaagatcga aaagatcttg     1380

actttccgca tcccgtacta cgtgggccct ctggcccgcg gcaactcccg cttcgcttgg     1440

atgacacgga agtccgagga aaccattacg ccctggaact tcgaggaagt ggtggacaag     1500

ggggcgtccg cccagagctt catcgaacgc atgaccaatt tcgacaagaa cctcccgaac     1560

gaaaaagtgc tgccaaagca ctcgctcctc tacgaatact tcaccgtgta caacgagctg     1620

actaaggtca aatacgtgac tgagggaatg cggaagccgg ccttcctgtc gggagagcag     1680

aagaaggcca tagtggactt gcttttcaag actaaccgga aggtcactgt gaagcaactc     1740

aaggaggact acttcaagaa gatcgagtgt ttcgactcgg tggagatctc gggtgtcgag     1800

gaccgcttca acgcctccct gggaacttac cacgatctgc tgaagatcat caaggacaag     1860

gacttcctcg ataacgaaga aaatgaggac atcctcgagg atatcgtgct gaccctgacc     1920

ttgttcgagg atagggagat gatcgaggag cggctcaaga cctacgccca cctgtttgac     1980

gacaaagtga tgaagcaact gaaacggcgg aggtataccg gctggggtcg gctgtcccgc     2040

aagctgatca acgggatcag ggacaagcag tccggaaaga ccatcctcga cttccttaag     2100

tccgacggat tcgcgaaccg caacttcatg caacttatcc acgacgactc gctgacattc     2160

aaggaagata tccagaaggc ccaggtgtcc ggacaggggg actcgcttca tgagcacatc     2220

gctaacctgg ccggatcccc cgccataaaa aagggcattc tgcagaccgt caaagtggtg     2280

gatgagctgg tcaaggtcat gggccggcat aagccggaaa acatcgtcat cgagatggcc     2340

cgcgagaacc agactacgca gaagggccag aagaactccc gggagcggat gaagcggatt     2400

gaagagggca tcaaggagct cggcagccag attctgaagg aacatcccgt ggaaaacacc     2460

cagctgcaaa acgaaaagct ctatttgtac tatctgcaaa acggacgcga tatgtacgtg     2520

gatcaggagc tggacattaa cagactgagc gactatgacg tggatcacat tgtgcctcaa     2580

agcttcctca aggacgactc aattgacaac aaggtcctga ccagaagcga caagaacaga     2640

ggaaagtcgg ataatgtgcc gtccgaagaa gtggtcaaga agatgaagaa ttactggaga     2700

cagctcctga atgcgaagct cattacccag cggaagttcg ataacctgac caaggccgaa     2760

aggggtggac tgtccgaact cgacaaagct ggcttcatca agcgccaact ggtcgaaacc     2820

aggcagatca ccaagcacgt cgcccagatt ctggacagcc gcatgaacac taagtacgac     2880

gagaacgata agctgatccg cgaagtgaag gtcatcaccc tgaagtccaa gctcgtgtcc     2940

gactttcgga aggatttcca gttttacaag gtccgcgaga tcaacaacta ccatcacgcc     3000

cacgacgcgt accttaacgc agtcgtggga acggctctta tcaagaagta cccaaagctg     3060

gagtcggaat ttgtgtacgg agactacaaa gtgtacgacg tgcgcaagat gatcgccaaa     3120

tctgagcaag agatcgggaa ggcaaccgcc aaatacttct tctactcaaa cattatgaat     3180

tttttcaaaa ctgagattac cctggctaac ggagaaattc ggaagcgccc cctgattgaa     3240

accaacggag aaactggaga aattgtgtgg gacaagggac gggacttcgc caccgtccgc     3300

aaggtcctct caatgcccca agtcaacatc gtgaaaaaga ccgaagtgca aaccggcggc     3360

ttctcaaagg agtccatcct gcctaagcgc aacagcgaca agctgattgc caggaagaag     3420

gactgggacc cgaagaagta cggaggattt gattccccta ccgtggccta ctccgtgctc     3480

gtggtggcca aagtggaaaa ggggaaatcc aagaagctga agtcggtgaa ggagcttttg     3540

ggtatcacca tcatggaacg ctcctcgttc gaaaagaacc caatcgattt cctggaagct     3600

aagggttata aggaagtgaa aaaggacctg attatcaagc tgcccaagta ctcactgttc     3660

gagctggaaa acggtcggaa aaggatgctg gccagcgccg gagaactcca gaagggaaac     3720

gaactggcac tgccgtccaa atacgtcaac ttcctctacc ttgcatccca ttacgaaaaa     3780

ctcaagggat cgccggagga caacgagcag aagcagcttt tcgtggagca acacaagcat     3840

tacttggacg agatcatcga gcagatttcc gagttctcaa agcgcgtgat cctggccgac     3900

gcaaatctgg acaaggtcct gtccgcgtac aataagcatc gggacaagcc tatccgcgaa     3960

caggccgaga acatcatcca tctgttcact ctgacaaacc tgggcgcacc cgccgcgttc     4020

aagtactttg acaccaccat cgataggaag cgatacacct caactaagga agtgttggac     4080

gcgaccctta tccatcagtc gatcaccggg ctgtacgaaa cacggatcga cctcagccag     4140

ttgggaggcg acaagcgccc tgcggctacc aagaaggccg gacaggccaa gaagaagaaa     4200

tga                                                                   4203


<210>  4
<211>  4203
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4
auggccccua agaagaagag aaaagucgga auucacggag uccccgccgc cgacaaaaag       60

uacuccauug gccuugauau uggaaccaac uccguggguu gggccgugau cacugacgag      120

uacaaggugc cguccaagaa guucaaggug cuggggaaca cugaccggca cucaauuaag      180

aagaaccuga uuggggcgcu gcuguucgac uccggagaaa ccgcggaggc uacccgccug      240

aagcggacug cccggcggag auacacgcgc aggaagaacc ggauuugcua ccuccaagaa      300

aucuucagca acgaaauggc aaagguggac gauuccuucu uccaucgccu ggaagagagc      360

uuccuggugg aagaggacaa gaagcacgaa agacacccga uuuucggcaa caucguggau      420

gaggucgcau accacgaaaa guaccccacc aucuaucauc uucggaagaa gcuggucgac      480

uccaccgaua aggccgaucu gcgccugauc uacuuggcgc uggcucacau gauuaaguuc      540

agaggacacu uucugauaga gggcgaccuc aaucccgaua acuccgacgu ggauaagcug      600

uucauccaac uggugcagac guacaaccaa cuguuugaag agaauccaau caacgccagc      660

gggguggacg ccaaggccau ccuguccgcc cggcugucaa aguccagacg ccuggagaau      720

cucaucgcgc aacucccugg cgaaaaaaag aacggacucu ucgggaaucu gauugcucug      780

ucccuggggc ucacuccgaa cuucaagucg aacuucgacc uggcggagga cgcuaagcug      840

cagcugucca aggacaccua cgaugacgau cuggauaacc uucuggccca gaucggggau      900

caauacgccg aucucuuccu ggccgcaaag aacuugucgg augcuauucu gcugagcgac      960

auucugcggg ucaauacuga aaucaccaag gcgccccugu cggccagcau gaucaagcgc     1020

uacgacgaac accaccaaga ccugacucug cugaaggccc ucgugcgcca gcagcugccu     1080

gaaaaguaca aggagauuuu cuucgaccag uccaagaacg gauacgccgg auacauugac     1140

ggaggggcca gccaggagga auuuuacaaa uucaucaagc ccauucucga gaaaauggac     1200

ggaaccgaag aguugcucgu gaagcugaac agagaggauc uccuccggaa gcagcggacc     1260

uucgacaacg guuccauccc gcaccaaauc caccugggcg aauugcacgc cauccuccgg     1320

cggcaggaag auuucuaccc auucuugaag gacaaucgcg aaaagaucga aaagaucuug     1380

acuuuccgca ucccguacua cgugggcccu cuggcccgcg gcaacucccg cuucgcuugg     1440

augacacgga aguccgagga aaccauuacg cccuggaacu ucgaggaagu gguggacaag     1500

ggggcguccg cccagagcuu caucgaacgc augaccaauu ucgacaagaa ccucccgaac     1560

gaaaaagugc ugccaaagca cucgcuccuc uacgaauacu ucaccgugua caacgagcug     1620

acuaagguca aauacgugac ugagggaaug cggaagccgg ccuuccuguc gggagagcag     1680

aagaaggcca uaguggacuu gcuuuucaag acuaaccgga aggucacugu gaagcaacuc     1740

aaggaggacu acuucaagaa gaucgagugu uucgacucgg uggagaucuc gggugucgag     1800

gaccgcuuca acgccucccu gggaacuuac cacgaucugc ugaagaucau caaggacaag     1860

gacuuccucg auaacgaaga aaaugaggac auccucgagg auaucgugcu gacccugacc     1920

uuguucgagg auagggagau gaucgaggag cggcucaaga ccuacgccca ccuguuugac     1980

gacaaaguga ugaagcaacu gaaacggcgg agguauaccg gcuggggucg gcugucccgc     2040

aagcugauca acgggaucag ggacaagcag uccggaaaga ccauccucga cuuccuuaag     2100

uccgacggau ucgcgaaccg caacuucaug caacuuaucc acgacgacuc gcugacauuc     2160

aaggaagaua uccagaaggc ccaggugucc ggacaggggg acucgcuuca ugagcacauc     2220

gcuaaccugg ccggaucccc cgccauaaaa aagggcauuc ugcagaccgu caaaguggug     2280

gaugagcugg ucaaggucau gggccggcau aagccggaaa acaucgucau cgagauggcc     2340

cgcgagaacc agacuacgca gaagggccag aagaacuccc gggagcggau gaagcggauu     2400

gaagagggca ucaaggagcu cggcagccag auucugaagg aacaucccgu ggaaaacacc     2460

cagcugcaaa acgaaaagcu cuauuuguac uaucugcaaa acggacgcga uauguacgug     2520

gaucaggagc uggacauuaa cagacugagc gacuaugacg uggaucacau ugugccucaa     2580

agcuuccuca aggacgacuc aauugacaac aagguccuga ccagaagcga caagaacaga     2640

ggaaagucgg auaaugugcc guccgaagaa guggucaaga agaugaagaa uuacuggaga     2700

cagcuccuga augcgaagcu cauuacccag cggaaguucg auaaccugac caaggccgaa     2760

agggguggac uguccgaacu cgacaaagcu ggcuucauca agcgccaacu ggucgaaacc     2820

aggcagauca ccaagcacgu cgcccagauu cuggacagcc gcaugaacac uaaguacgac     2880

gagaacgaua agcugauccg cgaagugaag gucaucaccc ugaaguccaa gcucgugucc     2940

gacuuucgga aggauuucca guuuuacaag guccgcgaga ucaacaacua ccaucacgcc     3000

cacgacgcgu accuuaacgc agucguggga acggcucuua ucaagaagua cccaaagcug     3060

gagucggaau uuguguacgg agacuacaaa guguacgacg ugcgcaagau gaucgccaaa     3120

ucugagcaag agaucgggaa ggcaaccgcc aaauacuucu ucuacucaaa cauuaugaau     3180

uuuuucaaaa cugagauuac ccuggcuaac ggagaaauuc ggaagcgccc ccugauugaa     3240

accaacggag aaacuggaga aauugugugg gacaagggac gggacuucgc caccguccgc     3300

aagguccucu caaugcccca agucaacauc gugaaaaaga ccgaagugca aaccggcggc     3360

uucucaaagg aguccauccu gccuaagcgc aacagcgaca agcugauugc caggaagaag     3420

gacugggacc cgaagaagua cggaggauuu gauuccccua ccguggccua cuccgugcuc     3480

gugguggcca aaguggaaaa ggggaaaucc aagaagcuga agucggugaa ggagcuuuug     3540

gguaucacca ucauggaacg cuccucguuc gaaaagaacc caaucgauuu ccuggaagcu     3600

aaggguuaua aggaagugaa aaaggaccug auuaucaagc ugcccaagua cucacuguuc     3660

gagcuggaaa acggucggaa aaggaugcug gccagcgccg gagaacucca gaagggaaac     3720

gaacuggcac ugccguccaa auacgucaac uuccucuacc uugcauccca uuacgaaaaa     3780

cucaagggau cgccggagga caacgagcag aagcagcuuu ucguggagca acacaagcau     3840

uacuuggacg agaucaucga gcagauuucc gaguucucaa agcgcgugau ccuggccgac     3900

gcaaaucugg acaagguccu guccgcguac aauaagcauc gggacaagcc uauccgcgaa     3960

caggccgaga acaucaucca ucuguucacu cugacaaacc ugggcgcacc cgccgcguuc     4020

aaguacuuug acaccaccau cgauaggaag cgauacaccu caacuaagga aguguuggac     4080

gcgacccuua uccaucaguc gaucaccggg cuguacgaaa cacggaucga ccucagccag     4140

uugggaggcg acaagcgccc ugcggcuacc aagaaggccg gacaggccaa gaagaagaaa     4200

uga                                                                   4203


<210>  5
<211>  1400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Ala Pro Lys Lys Lys Arg Lys Val Gly Ile His Gly Val Pro Ala 
1               5                   10                  15      


Ala Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
            20                  25                  30          


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
        35                  40                  45              


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
    50                  55                  60                  


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
65                  70                  75                  80  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
                85                  90                  95      


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
            100                 105                 110         


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
        115                 120                 125             


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
    130                 135                 140                 


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
145                 150                 155                 160 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
                165                 170                 175     


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
            180                 185                 190         


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
        195                 200                 205             


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
    210                 215                 220                 


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
225                 230                 235                 240 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
                245                 250                 255     


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
            260                 265                 270         


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
        275                 280                 285             


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
    290                 295                 300                 


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
305                 310                 315                 320 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
                325                 330                 335     


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
            340                 345                 350         


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
        355                 360                 365             


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
    370                 375                 380                 


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
385                 390                 395                 400 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
                405                 410                 415     


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
            420                 425                 430         


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
        435                 440                 445             


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
    450                 455                 460                 


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
465                 470                 475                 480 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
                485                 490                 495     


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
            500                 505                 510         


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
        515                 520                 525             


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
    530                 535                 540                 


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
545                 550                 555                 560 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
                565                 570                 575     


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
            580                 585                 590         


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
        595                 600                 605             


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
    610                 615                 620                 


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
625                 630                 635                 640 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
                645                 650                 655     


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
            660                 665                 670         


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
        675                 680                 685             


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
    690                 695                 700                 


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
705                 710                 715                 720 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
                725                 730                 735     


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
            740                 745                 750         


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
        755                 760                 765             


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
    770                 775                 780                 


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
785                 790                 795                 800 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
                805                 810                 815     


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
            820                 825                 830         


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
        835                 840                 845             


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
    850                 855                 860                 


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
865                 870                 875                 880 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
                885                 890                 895     


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
            900                 905                 910         


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
        915                 920                 925             


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
    930                 935                 940                 


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
945                 950                 955                 960 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
                965                 970                 975     


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
            980                 985                 990         


Glu Ile Asn Asn Tyr His His Ala  His Asp Ala Tyr Leu  Asn Ala Val 
        995                 1000                 1005             


Val Gly  Thr Ala Leu Ile Lys  Lys Tyr Pro Lys Leu  Glu Ser Glu 
    1010                 1015                 1020             


Phe Val  Tyr Gly Asp Tyr Lys  Val Tyr Asp Val Arg  Lys Met Ile 
    1025                 1030                 1035             


Ala Lys  Ser Glu Gln Glu Ile  Gly Lys Ala Thr Ala  Lys Tyr Phe 
    1040                 1045                 1050             


Phe Tyr  Ser Asn Ile Met Asn  Phe Phe Lys Thr Glu  Ile Thr Leu 
    1055                 1060                 1065             


Ala Asn  Gly Glu Ile Arg Lys  Arg Pro Leu Ile Glu  Thr Asn Gly 
    1070                 1075                 1080             


Glu Thr  Gly Glu Ile Val Trp  Asp Lys Gly Arg Asp  Phe Ala Thr 
    1085                 1090                 1095             


Val Arg  Lys Val Leu Ser Met  Pro Gln Val Asn Ile  Val Lys Lys 
    1100                 1105                 1110             


Thr Glu  Val Gln Thr Gly Gly  Phe Ser Lys Glu Ser  Ile Leu Pro 
    1115                 1120                 1125             


Lys Arg  Asn Ser Asp Lys Leu  Ile Ala Arg Lys Lys  Asp Trp Asp 
    1130                 1135                 1140             


Pro Lys  Lys Tyr Gly Gly Phe  Asp Ser Pro Thr Val  Ala Tyr Ser 
    1145                 1150                 1155             


Val Leu  Val Val Ala Lys Val  Glu Lys Gly Lys Ser  Lys Lys Leu 
    1160                 1165                 1170             


Lys Ser  Val Lys Glu Leu Leu  Gly Ile Thr Ile Met  Glu Arg Ser 
    1175                 1180                 1185             


Ser Phe  Glu Lys Asn Pro Ile  Asp Phe Leu Glu Ala  Lys Gly Tyr 
    1190                 1195                 1200             


Lys Glu  Val Lys Lys Asp Leu  Ile Ile Lys Leu Pro  Lys Tyr Ser 
    1205                 1210                 1215             


Leu Phe  Glu Leu Glu Asn Gly  Arg Lys Arg Met Leu  Ala Ser Ala 
    1220                 1225                 1230             


Gly Glu  Leu Gln Lys Gly Asn  Glu Leu Ala Leu Pro  Ser Lys Tyr 
    1235                 1240                 1245             


Val Asn  Phe Leu Tyr Leu Ala  Ser His Tyr Glu Lys  Leu Lys Gly 
    1250                 1255                 1260             


Ser Pro  Glu Asp Asn Glu Gln  Lys Gln Leu Phe Val  Glu Gln His 
    1265                 1270                 1275             


Lys His  Tyr Leu Asp Glu Ile  Ile Glu Gln Ile Ser  Glu Phe Ser 
    1280                 1285                 1290             


Lys Arg  Val Ile Leu Ala Asp  Ala Asn Leu Asp Lys  Val Leu Ser 
    1295                 1300                 1305             


Ala Tyr  Asn Lys His Arg Asp  Lys Pro Ile Arg Glu  Gln Ala Glu 
    1310                 1315                 1320             


Asn Ile  Ile His Leu Phe Thr  Leu Thr Asn Leu Gly  Ala Pro Ala 
    1325                 1330                 1335             


Ala Phe  Lys Tyr Phe Asp Thr  Thr Ile Asp Arg Lys  Arg Tyr Thr 
    1340                 1345                 1350             


Ser Thr  Lys Glu Val Leu Asp  Ala Thr Leu Ile His  Gln Ser Ile 
    1355                 1360                 1365             


Thr Gly  Leu Tyr Glu Thr Arg  Ile Asp Leu Ser Gln  Leu Gly Gly 
    1370                 1375                 1380             


Asp Lys  Arg Pro Ala Ala Thr  Lys Lys Ala Gly Gln  Ala Lys Lys 
    1385                 1390                 1395             


Lys Lys  
    1400 


<210>  6
<211>  1367
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly 
1               5                   10                  15      


Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys 
            20                  25                  30          


Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly 
        35                  40                  45              


Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys 
    50                  55                  60                  


Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr 
65                  70                  75                  80  


Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe 
                85                  90                  95      


Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His 
            100                 105                 110         


Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His 
        115                 120                 125             


Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser 
    130                 135                 140                 


Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met 
145                 150                 155                 160 


Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp 
                165                 170                 175     


Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn 
            180                 185                 190         


Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys 
        195                 200                 205             


Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu 
    210                 215                 220                 


Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp 
                245                 250                 255     


Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp 
            260                 265                 270         


Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu 
        275                 280                 285             


Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile 
    290                 295                 300                 


Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met 
305                 310                 315                 320 


Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys Ala 
                325                 330                 335     


Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp 
            340                 345                 350         


Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln 
        355                 360                 365             


Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly 
    370                 375                 380                 


Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys 
385                 390                 395                 400 


Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu Gly 
                405                 410                 415     


Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu 
            420                 425                 430         


Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro 
        435                 440                 445             


Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met 
    450                 455                 460                 


Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val 
465                 470                 475                 480 


Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn 
                485                 490                 495     


Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu 
            500                 505                 510         


Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr 
        515                 520                 525             


Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys 
    530                 535                 540                 


Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val 
545                 550                 555                 560 


Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser 
                565                 570                 575     


Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr 
            580                 585                 590         


Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn 
        595                 600                 605             


Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu 
    610                 615                 620                 


Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His 
625                 630                 635                 640 


Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr 
                645                 650                 655     


Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys 
            660                 665                 670         


Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala 
        675                 680                 685             


Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys 
    690                 695                 700                 


Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His 
705                 710                 715                 720 


Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile 
                725                 730                 735     


Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly Arg 
            740                 745                 750         


His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr 
        755                 760                 765             


Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu 
    770                 775                 780                 


Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val 
785                 790                 795                 800 


Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln 
                805                 810                 815     


Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu 
            820                 825                 830         


Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp 
        835                 840                 845             


Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly 
    850                 855                 860                 


Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn 
865                 870                 875                 880 


Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe 
                885                 890                 895     


Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys 
            900                 905                 910         


Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys 
        915                 920                 925             


His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu 
    930                 935                 940                 


Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys 
945                 950                 955                 960 


Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu 
                965                 970                 975     


Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val Val 
            980                 985                 990         


Gly Thr Ala Leu Ile Lys Lys Tyr  Pro Lys Leu Glu Ser  Glu Phe Val 
        995                 1000                 1005             


Tyr Gly  Asp Tyr Lys Val Tyr  Asp Val Arg Lys Met  Ile Ala Lys 
    1010                 1015                 1020             


Ser Glu  Gln Glu Ile Gly Lys  Ala Thr Ala Lys Tyr  Phe Phe Tyr 
    1025                 1030                 1035             


Ser Asn  Ile Met Asn Phe Phe  Lys Thr Glu Ile Thr  Leu Ala Asn 
    1040                 1045                 1050             


Gly Glu  Ile Arg Lys Arg Pro  Leu Ile Glu Thr Asn  Gly Glu Thr 
    1055                 1060                 1065             


Gly Glu  Ile Val Trp Asp Lys  Gly Arg Asp Phe Ala  Thr Val Arg 
    1070                 1075                 1080             


Lys Val  Leu Ser Met Pro Gln  Val Asn Ile Val Lys  Lys Thr Glu 
    1085                 1090                 1095             


Val Gln  Thr Gly Gly Phe Ser  Lys Glu Ser Ile Leu  Pro Lys Arg 
    1100                 1105                 1110             


Asn Ser  Asp Lys Leu Ile Ala  Arg Lys Lys Asp Trp  Asp Pro Lys 
    1115                 1120                 1125             


Lys Tyr  Gly Gly Phe Asp Ser  Pro Thr Val Ala Tyr  Ser Val Leu 
    1130                 1135                 1140             


Val Val  Ala Lys Val Glu Lys  Gly Lys Ser Lys Lys  Leu Lys Ser 
    1145                 1150                 1155             


Val Lys  Glu Leu Leu Gly Ile  Thr Ile Met Glu Arg  Ser Ser Phe 
    1160                 1165                 1170             


Glu Lys  Asn Pro Ile Asp Phe  Leu Glu Ala Lys Gly  Tyr Lys Glu 
    1175                 1180                 1185             


Val Lys  Lys Asp Leu Ile Ile  Lys Leu Pro Lys Tyr  Ser Leu Phe 
    1190                 1195                 1200             


Glu Leu  Glu Asn Gly Arg Lys  Arg Met Leu Ala Ser  Ala Gly Glu 
    1205                 1210                 1215             


Leu Gln  Lys Gly Asn Glu Leu  Ala Leu Pro Ser Lys  Tyr Val Asn 
    1220                 1225                 1230             


Phe Leu  Tyr Leu Ala Ser His  Tyr Glu Lys Leu Lys  Gly Ser Pro 
    1235                 1240                 1245             


Glu Asp  Asn Glu Gln Lys Gln  Leu Phe Val Glu Gln  His Lys His 
    1250                 1255                 1260             


Tyr Leu  Asp Glu Ile Ile Glu  Gln Ile Ser Glu Phe  Ser Lys Arg 
    1265                 1270                 1275             


Val Ile  Leu Ala Asp Ala Asn  Leu Asp Lys Val Leu  Ser Ala Tyr 
    1280                 1285                 1290             


Asn Lys  His Arg Asp Lys Pro  Ile Arg Glu Gln Ala  Glu Asn Ile 
    1295                 1300                 1305             


Ile His  Leu Phe Thr Leu Thr  Asn Leu Gly Ala Pro  Ala Ala Phe 
    1310                 1315                 1320             


Lys Tyr  Phe Asp Thr Thr Ile  Asp Arg Lys Arg Tyr  Thr Ser Thr 
    1325                 1330                 1335             


Lys Glu  Val Leu Asp Ala Thr  Leu Ile His Gln Ser  Ile Thr Gly 
    1340                 1345                 1350             


Leu Tyr  Glu Thr Arg Ile Asp  Leu Ser Gln Leu Gly  Gly Asp 
    1355                 1360                 1365         


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Lys Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
1               5                   10                  15      


<210>  8
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  9
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
agaggaaata agagagaaaa gaagagtaag aagaaatata agagccacc                   49


<210>  10
<211>  49
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
agaggaaaua agagagaaaa gaagaguaag aagaaauaua agagccacc                   49


<210>  11
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gcggccgctt aattaagctg ccttctgcgg ggcttgcctt ctggccatgc ccttcttctc       60

tcccttgcac ctgtacctct tggtctttga ataaagcctg agtaggaagt ctag            114


<210>  12
<211>  114
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
gcggccgcuu aauuaagcug ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc       60

ucccuugcac cuguaccucu uggucuuuga auaaagccug aguaggaagu cuag            114


<210>  13
<211>  140
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa       60

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      120

aaaaaaaaaa aaaaaaaaaa                                                  140


<210>  14
<211>  4504
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
aggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gccccuaaga       60

agaagagaaa agucggaauu cacggagucc ccgccgccga caaaaaguac uccauuggcc      120

uugauauugg aaccaacucc guggguuggg ccgugaucac ugacgaguac aaggugccgu      180

ccaagaaguu caaggugcug gggaacacug accggcacuc aauuaagaag aaccugauug      240

gggcgcugcu guucgacucc ggagaaaccg cggaggcuac ccgccugaag cggacugccc      300

ggcggagaua cacgcgcagg aagaaccgga uuugcuaccu ccaagaaauc uucagcaacg      360

aaauggcaaa gguggacgau uccuucuucc aucgccugga agagagcuuc cugguggaag      420

aggacaagaa gcacgaaaga cacccgauuu ucggcaacau cguggaugag gucgcauacc      480

acgaaaagua ccccaccauc uaucaucuuc ggaagaagcu ggucgacucc accgauaagg      540

ccgaucugcg ccugaucuac uuggcgcugg cucacaugau uaaguucaga ggacacuuuc      600

ugauagaggg cgaccucaau cccgauaacu ccgacgugga uaagcuguuc auccaacugg      660

ugcagacgua caaccaacug uuugaagaga auccaaucaa cgccagcggg guggacgcca      720

aggccauccu guccgcccgg cugucaaagu ccagacgccu ggagaaucuc aucgcgcaac      780

ucccuggcga aaaaaagaac ggacucuucg ggaaucugau ugcucugucc cuggggcuca      840

cuccgaacuu caagucgaac uucgaccugg cggaggacgc uaagcugcag cuguccaagg      900

acaccuacga ugacgaucug gauaaccuuc uggcccagau cggggaucaa uacgccgauc      960

ucuuccuggc cgcaaagaac uugucggaug cuauucugcu gagcgacauu cugcggguca     1020

auacugaaau caccaaggcg ccccugucgg ccagcaugau caagcgcuac gacgaacacc     1080

accaagaccu gacucugcug aaggcccucg ugcgccagca gcugccugaa aaguacaagg     1140

agauuuucuu cgaccagucc aagaacggau acgccggaua cauugacgga ggggccagcc     1200

aggaggaauu uuacaaauuc aucaagccca uucucgagaa aauggacgga accgaagagu     1260

ugcucgugaa gcugaacaga gaggaucucc uccggaagca gcggaccuuc gacaacgguu     1320

ccaucccgca ccaaauccac cugggcgaau ugcacgccau ccuccggcgg caggaagauu     1380

ucuacccauu cuugaaggac aaucgcgaaa agaucgaaaa gaucuugacu uuccgcaucc     1440

cguacuacgu gggcccucug gcccgcggca acucccgcuu cgcuuggaug acacggaagu     1500

ccgaggaaac cauuacgccc uggaacuucg aggaaguggu ggacaagggg gcguccgccc     1560

agagcuucau cgaacgcaug accaauuucg acaagaaccu cccgaacgaa aaagugcugc     1620

caaagcacuc gcuccucuac gaauacuuca ccguguacaa cgagcugacu aaggucaaau     1680

acgugacuga gggaaugcgg aagccggccu uccugucggg agagcagaag aaggccauag     1740

uggacuugcu uuucaagacu aaccggaagg ucacugugaa gcaacucaag gaggacuacu     1800

ucaagaagau cgaguguuuc gacucggugg agaucucggg ugucgaggac cgcuucaacg     1860

ccucccuggg aacuuaccac gaucugcuga agaucaucaa ggacaaggac uuccucgaua     1920

acgaagaaaa ugaggacauc cucgaggaua ucgugcugac ccugaccuug uucgaggaua     1980

gggagaugau cgaggagcgg cucaagaccu acgcccaccu guuugacgac aaagugauga     2040

agcaacugaa acggcggagg uauaccggcu ggggucggcu gucccgcaag cugaucaacg     2100

ggaucaggga caagcagucc ggaaagacca uccucgacuu ccuuaagucc gacggauucg     2160

cgaaccgcaa cuucaugcaa cuuauccacg acgacucgcu gacauucaag gaagauaucc     2220

agaaggccca gguguccgga cagggggacu cgcuucauga gcacaucgcu aaccuggccg     2280

gaucccccgc cauaaaaaag ggcauucugc agaccgucaa agugguggau gagcugguca     2340

aggucauggg ccggcauaag ccggaaaaca ucgucaucga gauggcccgc gagaaccaga     2400

cuacgcagaa gggccagaag aacucccggg agcggaugaa gcggauugaa gagggcauca     2460

aggagcucgg cagccagauu cugaaggaac aucccgugga aaacacccag cugcaaaacg     2520

aaaagcucua uuuguacuau cugcaaaacg gacgcgauau guacguggau caggagcugg     2580

acauuaacag acugagcgac uaugacgugg aucacauugu gccucaaagc uuccucaagg     2640

acgacucaau ugacaacaag guccugacca gaagcgacaa gaacagagga aagucggaua     2700

augugccguc cgaagaagug gucaagaaga ugaagaauua cuggagacag cuccugaaug     2760

cgaagcucau uacccagcgg aaguucgaua accugaccaa ggccgaaagg gguggacugu     2820

ccgaacucga caaagcuggc uucaucaagc gccaacuggu cgaaaccagg cagaucacca     2880

agcacgucgc ccagauucug gacagccgca ugaacacuaa guacgacgag aacgauaagc     2940

ugauccgcga agugaagguc aucacccuga aguccaagcu cguguccgac uuucggaagg     3000

auuuccaguu uuacaagguc cgcgagauca acaacuacca ucacgcccac gacgcguacc     3060

uuaacgcagu cgugggaacg gcucuuauca agaaguaccc aaagcuggag ucggaauuug     3120

uguacggaga cuacaaagug uacgacgugc gcaagaugau cgccaaaucu gagcaagaga     3180

ucgggaaggc aaccgccaaa uacuucuucu acucaaacau uaugaauuuu uucaaaacug     3240

agauuacccu ggcuaacgga gaaauucgga agcgcccccu gauugaaacc aacggagaaa     3300

cuggagaaau ugugugggac aagggacggg acuucgccac cguccgcaag guccucucaa     3360

ugccccaagu caacaucgug aaaaagaccg aagugcaaac cggcggcuuc ucaaaggagu     3420

ccauccugcc uaagcgcaac agcgacaagc ugauugccag gaagaaggac ugggacccga     3480

agaaguacgg aggauuugau uccccuaccg uggccuacuc cgugcucgug guggccaaag     3540

uggaaaaggg gaaauccaag aagcugaagu cggugaagga gcuuuugggu aucaccauca     3600

uggaacgcuc cucguucgaa aagaacccaa ucgauuuccu ggaagcuaag gguuauaagg     3660

aagugaaaaa ggaccugauu aucaagcugc ccaaguacuc acuguucgag cuggaaaacg     3720

gucggaaaag gaugcuggcc agcgccggag aacuccagaa gggaaacgaa cuggcacugc     3780

cguccaaaua cgucaacuuc cucuaccuug caucccauua cgaaaaacuc aagggaucgc     3840

cggaggacaa cgagcagaag cagcuuuucg uggagcaaca caagcauuac uuggacgaga     3900

ucaucgagca gauuuccgag uucucaaagc gcgugauccu ggccgacgca aaucuggaca     3960

agguccuguc cgcguacaau aagcaucggg acaagccuau ccgcgaacag gccgagaaca     4020

ucauccaucu guucacucug acaaaccugg gcgcacccgc cgcguucaag uacuuugaca     4080

ccaccaucga uaggaagcga uacaccucaa cuaaggaagu guuggacgcg acccuuaucc     4140

aucagucgau caccgggcug uacgaaacac ggaucgaccu cagccaguug ggaggcgaca     4200

agcgcccugc ggcuaccaag aaggccggac aggccaagaa gaagaaauga gcggccgcuu     4260

aauuaagcug ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac     4320

cuguaccucu uggucuuuga auaaagccug aguaggaagu cuagaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4500

aaaa                                                                  4504


<210>  15
<211>  47
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
aggaaauaag agagaaaaga agaguaagaa gaaauauaag agccacc                     47


<210>  16
<211>  4444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
aggaaataag agagaaaaga agagtaagaa gaaatataag agccaccatg gccccaaaga       60

agaagcggaa ggtcggtatc cacggagtcc cagcagccga caagaagtac agcatcggcc      120

tggacatcgg caccaactct gtgggctggg ccgtgatcac cgacgagtac aaggtgccca      180

gcaagaaatt caaggtgctg ggcaacaccg accggcacag catcaagaag aacctgatcg      240

gagccctgct gttcgacagc ggcgaaacag ccgaggccac ccggctgaag agaaccgcca      300

gaagaagata caccagacgg aagaaccgga tctgctatct gcaagagatc ttcagcaacg      360

agatggccaa ggtggacgac agcttcttcc acagactgga agagtccttc ctggtggaag      420

aggacaagaa gcacgagaga caccccatct tcggcaacat cgtggacgag gtggcctacc      480

acgagaagta ccccaccatc taccacctga gaaagaaact ggtggacagc accgacaagg      540

ccgacctgag actgatctac ctggccctgg cccacatgat caagttcaga ggccacttcc      600

tgatcgaggg cgacctgaac cccgacaaca gcgacgtgga caagctgttc atccagctgg      660

tgcagaccta caaccagctg ttcgaggaaa accccatcaa cgccagcggc gtggacgcca      720

aggctatcct gtctgccaga ctgagcaaga gcagaaggct ggaaaatctg atcgcccagc      780

tgcccggcga gaagaagaac ggcctgttcg gcaacctgat tgccctgagc ctgggcctga      840

cccccaactt caagagcaac ttcgacctgg ccgaggatgc caaactgcag ctgagcaagg      900

acacctacga cgacgacctg gacaacctgc tggcccagat cggcgaccag tacgccgacc      960

tgttcctggc cgccaagaac ctgtctgacg ccatcctgct gagcgacatc ctgagagtga     1020

acaccgagat caccaaggcc cccctgagcg cctctatgat caagagatac gacgagcacc     1080

accaggacct gaccctgctg aaagctctcg tgcggcagca gctgcctgag aagtacaaag     1140

aaatcttctt cgaccagagc aagaacggct acgccggcta catcgatggc ggcgctagcc     1200

aggaagagtt ctacaagttc atcaagccca tcctggaaaa gatggacggc accgaggaac     1260

tgctcgtgaa gctgaacaga gaggacctgc tgagaaagca gagaaccttc gacaacggca     1320

gcatccccca ccagatccac ctgggagagc tgcacgctat cctgagaagg caggaagatt     1380

tttacccatt cctgaaggac aaccgggaaa agatcgagaa gatcctgacc ttcaggatcc     1440

cctactacgt gggccccctg gccagaggca acagcagatt cgcctggatg accagaaaga     1500

gcgaggaaac catcaccccc tggaacttcg aggaagtggt ggacaagggc gccagcgccc     1560

agagcttcat cgagagaatg acaaacttcg ataagaacct gcccaacgag aaggtgctgc     1620

ccaagcacag cctgctgtac gagtacttca ccgtgtacaa cgagctgacc aaagtgaaat     1680

acgtgaccga gggaatgaga aagcccgcct tcctgagcgg cgagcagaaa aaggccatcg     1740

tggacctgct gttcaagacc aacagaaaag tgaccgtgaa gcagctgaaa gaggactact     1800

tcaagaaaat cgagtgcttc gactccgtgg aaatctccgg cgtggaagat agattcaacg     1860

cctccctggg cacataccac gatctgctga aaattatcaa ggacaaggac ttcctggata     1920

acgaagagaa cgaggacatt ctggaagata tcgtgctgac cctgacactg tttgaggacc     1980

gcgagatgat cgaggaaagg ctgaaaacct acgctcacct gttcgacgac aaagtgatga     2040

agcagctgaa gagaaggcgg tacaccggct ggggcaggct gagcagaaag ctgatcaacg     2100

gcatcagaga caagcagagc ggcaagacaa tcctggattt cctgaagtcc gacggcttcg     2160

ccaaccggaa cttcatgcag ctgatccacg acgacagcct gacattcaaa gaggacatcc     2220

agaaagccca ggtgtccggc cagggcgact ctctgcacga gcatatcgct aacctggccg     2280

gcagccccgc tatcaagaag ggcatcctgc agacagtgaa ggtggtggac gagctcgtga     2340

aagtgatggg cagacacaag cccgagaaca tcgtgatcga gatggctaga gagaaccaga     2400

ccacccagaa gggacagaag aactcccgcg agaggatgaa gagaatcgaa gagggcatca     2460

aagagctggg cagccagatc ctgaaagaac accccgtgga aaacacccag ctgcagaacg     2520

agaagctgta cctgtactac ctgcagaatg gccgggatat gtacgtggac caggaactgg     2580

acatcaacag actgtccgac tacgatgtgg accatatcgt gcctcagagc tttctgaagg     2640

acgactccat cgataacaaa gtgctgactc ggagcgacaa gaacagaggc aagagcgaca     2700

acgtgccctc cgaagaggtc gtgaagaaga tgaagaacta ctggcgacag ctgctgaacg     2760

ccaagctgat tacccagagg aagttcgata acctgaccaa ggccgagaga ggcggcctga     2820

gcgagctgga taaggccggc ttcatcaaga ggcagctggt ggaaaccaga cagatcacaa     2880

agcacgtggc acagatcctg gactcccgga tgaacactaa gtacgacgaa aacgataagc     2940

tgatccggga agtgaaagtg atcaccctga agtccaagct ggtgtccgat ttccggaagg     3000

atttccagtt ttacaaagtg cgcgagatca acaactacca ccacgcccac gacgcctacc     3060

tgaacgccgt cgtgggaacc gccctgatca aaaagtaccc taagctggaa agcgagttcg     3120

tgtacggcga ctacaaggtg tacgacgtgc ggaagatgat cgccaagagc gagcaggaaa     3180

tcggcaaggc taccgccaag tacttcttct acagcaacat catgaacttt ttcaagaccg     3240

aaatcaccct ggccaacggc gagatcagaa agcgccctct gatcgagaca aacggcgaaa     3300

ccggggagat cgtgtgggat aagggcagag acttcgccac agtgcgaaag gtgctgagca     3360

tgccccaagt gaatatcgtg aaaaagaccg aggtgcagac aggcggcttc agcaaagagt     3420

ctatcctgcc caagaggaac agcgacaagc tgatcgccag aaagaaggac tgggacccca     3480

agaagtacgg cggcttcgac agccctaccg tggcctactc tgtgctggtg gtggctaagg     3540

tggaaaaggg caagtccaag aaactgaaga gtgtgaaaga gctgctgggg atcaccatca     3600

tggaaagaag cagctttgag aagaacccta tcgactttct ggaagccaag ggctacaaag     3660

aagtgaaaaa ggacctgatc atcaagctgc ctaagtactc cctgttcgag ctggaaaacg     3720

gcagaaagag aatgctggcc tctgccggcg aactgcagaa gggaaacgag ctggccctgc     3780

ctagcaaata tgtgaacttc ctgtacctgg cctcccacta tgagaagctg aagggcagcc     3840

ctgaggacaa cgaacagaaa cagctgtttg tggaacagca taagcactac ctggacgaga     3900

tcatcgagca gatcagcgag ttctccaaga gagtgatcct ggccgacgcc aatctggaca     3960

aggtgctgtc tgcctacaac aagcacaggg acaagcctat cagagagcag gccgagaata     4020

tcatccacct gttcaccctg acaaacctgg gcgctcctgc cgccttcaag tactttgaca     4080

ccaccatcga ccggaagagg tacaccagca ccaaagaggt gctggacgcc accctgatcc     4140

accagagcat caccggcctg tacgagacaa gaatcgacct gtctcagctg ggaggcgaca     4200

agagacctgc cgccactaag aaggccggac aggccaaaaa gaagaagtga gcggccgctt     4260

aattaagctg ccttctgcgg ggcttgcctt ctggccatgc ccttcttctc tcccttgcac     4320

ctgtacctct tggtctttga ataaagcctg agtaggaagt ctagaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaa                                                                  4444


<210>  17
<211>  4444
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17
aggaaauaag agagaaaaga agaguaagaa gaaauauaag agccaccaug gccccaaaga       60

agaagcggaa ggucgguauc cacggagucc cagcagccga caagaaguac agcaucggcc      120

uggacaucgg caccaacucu gugggcuggg ccgugaucac cgacgaguac aaggugccca      180

gcaagaaauu caaggugcug ggcaacaccg accggcacag caucaagaag aaccugaucg      240

gagcccugcu guucgacagc ggcgaaacag ccgaggccac ccggcugaag agaaccgcca      300

gaagaagaua caccagacgg aagaaccgga ucugcuaucu gcaagagauc uucagcaacg      360

agauggccaa gguggacgac agcuucuucc acagacugga agaguccuuc cugguggaag      420

aggacaagaa gcacgagaga caccccaucu ucggcaacau cguggacgag guggccuacc      480

acgagaagua ccccaccauc uaccaccuga gaaagaaacu gguggacagc accgacaagg      540

ccgaccugag acugaucuac cuggcccugg cccacaugau caaguucaga ggccacuucc      600

ugaucgaggg cgaccugaac cccgacaaca gcgacgugga caagcuguuc auccagcugg      660

ugcagaccua caaccagcug uucgaggaaa accccaucaa cgccagcggc guggacgcca      720

aggcuauccu gucugccaga cugagcaaga gcagaaggcu ggaaaaucug aucgcccagc      780

ugcccggcga gaagaagaac ggccuguucg gcaaccugau ugcccugagc cugggccuga      840

cccccaacuu caagagcaac uucgaccugg ccgaggaugc caaacugcag cugagcaagg      900

acaccuacga cgacgaccug gacaaccugc uggcccagau cggcgaccag uacgccgacc      960

uguuccuggc cgccaagaac cugucugacg ccauccugcu gagcgacauc cugagaguga     1020

acaccgagau caccaaggcc ccccugagcg ccucuaugau caagagauac gacgagcacc     1080

accaggaccu gacccugcug aaagcucucg ugcggcagca gcugccugag aaguacaaag     1140

aaaucuucuu cgaccagagc aagaacggcu acgccggcua caucgauggc ggcgcuagcc     1200

aggaagaguu cuacaaguuc aucaagccca uccuggaaaa gauggacggc accgaggaac     1260

ugcucgugaa gcugaacaga gaggaccugc ugagaaagca gagaaccuuc gacaacggca     1320

gcauccccca ccagauccac cugggagagc ugcacgcuau ccugagaagg caggaagauu     1380

uuuacccauu ccugaaggac aaccgggaaa agaucgagaa gauccugacc uucaggaucc     1440

ccuacuacgu gggcccccug gccagaggca acagcagauu cgccuggaug accagaaaga     1500

gcgaggaaac caucaccccc uggaacuucg aggaaguggu ggacaagggc gccagcgccc     1560

agagcuucau cgagagaaug acaaacuucg auaagaaccu gcccaacgag aaggugcugc     1620

ccaagcacag ccugcuguac gaguacuuca ccguguacaa cgagcugacc aaagugaaau     1680

acgugaccga gggaaugaga aagcccgccu uccugagcgg cgagcagaaa aaggccaucg     1740

uggaccugcu guucaagacc aacagaaaag ugaccgugaa gcagcugaaa gaggacuacu     1800

ucaagaaaau cgagugcuuc gacuccgugg aaaucuccgg cguggaagau agauucaacg     1860

ccucccuggg cacauaccac gaucugcuga aaauuaucaa ggacaaggac uuccuggaua     1920

acgaagagaa cgaggacauu cuggaagaua ucgugcugac ccugacacug uuugaggacc     1980

gcgagaugau cgaggaaagg cugaaaaccu acgcucaccu guucgacgac aaagugauga     2040

agcagcugaa gagaaggcgg uacaccggcu ggggcaggcu gagcagaaag cugaucaacg     2100

gcaucagaga caagcagagc ggcaagacaa uccuggauuu ccugaagucc gacggcuucg     2160

ccaaccggaa cuucaugcag cugauccacg acgacagccu gacauucaaa gaggacaucc     2220

agaaagccca gguguccggc cagggcgacu cucugcacga gcauaucgcu aaccuggccg     2280

gcagccccgc uaucaagaag ggcauccugc agacagugaa ggugguggac gagcucguga     2340

aagugauggg cagacacaag cccgagaaca ucgugaucga gauggcuaga gagaaccaga     2400

ccacccagaa gggacagaag aacucccgcg agaggaugaa gagaaucgaa gagggcauca     2460

aagagcuggg cagccagauc cugaaagaac accccgugga aaacacccag cugcagaacg     2520

agaagcugua ccuguacuac cugcagaaug gccgggauau guacguggac caggaacugg     2580

acaucaacag acuguccgac uacgaugugg accauaucgu gccucagagc uuucugaagg     2640

acgacuccau cgauaacaaa gugcugacuc ggagcgacaa gaacagaggc aagagcgaca     2700

acgugcccuc cgaagagguc gugaagaaga ugaagaacua cuggcgacag cugcugaacg     2760

ccaagcugau uacccagagg aaguucgaua accugaccaa ggccgagaga ggcggccuga     2820

gcgagcugga uaaggccggc uucaucaaga ggcagcuggu ggaaaccaga cagaucacaa     2880

agcacguggc acagauccug gacucccgga ugaacacuaa guacgacgaa aacgauaagc     2940

ugauccggga agugaaagug aucacccuga aguccaagcu gguguccgau uuccggaagg     3000

auuuccaguu uuacaaagug cgcgagauca acaacuacca ccacgcccac gacgccuacc     3060

ugaacgccgu cgugggaacc gcccugauca aaaaguaccc uaagcuggaa agcgaguucg     3120

uguacggcga cuacaaggug uacgacgugc ggaagaugau cgccaagagc gagcaggaaa     3180

ucggcaaggc uaccgccaag uacuucuucu acagcaacau caugaacuuu uucaagaccg     3240

aaaucacccu ggccaacggc gagaucagaa agcgcccucu gaucgagaca aacggcgaaa     3300

ccggggagau cgugugggau aagggcagag acuucgccac agugcgaaag gugcugagca     3360

ugccccaagu gaauaucgug aaaaagaccg aggugcagac aggcggcuuc agcaaagagu     3420

cuauccugcc caagaggaac agcgacaagc ugaucgccag aaagaaggac ugggacccca     3480

agaaguacgg cggcuucgac agcccuaccg uggccuacuc ugugcuggug guggcuaagg     3540

uggaaaaggg caaguccaag aaacugaaga gugugaaaga gcugcugggg aucaccauca     3600

uggaaagaag cagcuuugag aagaacccua ucgacuuucu ggaagccaag ggcuacaaag     3660

aagugaaaaa ggaccugauc aucaagcugc cuaaguacuc ccuguucgag cuggaaaacg     3720

gcagaaagag aaugcuggcc ucugccggcg aacugcagaa gggaaacgag cuggcccugc     3780

cuagcaaaua ugugaacuuc cuguaccugg ccucccacua ugagaagcug aagggcagcc     3840

cugaggacaa cgaacagaaa cagcuguuug uggaacagca uaagcacuac cuggacgaga     3900

ucaucgagca gaucagcgag uucuccaaga gagugauccu ggccgacgcc aaucuggaca     3960

aggugcuguc ugccuacaac aagcacaggg acaagccuau cagagagcag gccgagaaua     4020

ucauccaccu guucacccug acaaaccugg gcgcuccugc cgccuucaag uacuuugaca     4080

ccaccaucga ccggaagagg uacaccagca ccaaagaggu gcuggacgcc acccugaucc     4140

accagagcau caccggccug uacgagacaa gaaucgaccu gucucagcug ggaggcgaca     4200

agagaccugc cgccacuaag aaggccggac aggccaaaaa gaagaaguga gcggccgcuu     4260

aauuaagcug ccuucugcgg ggcuugccuu cuggccaugc ccuucuucuc ucccuugcac     4320

cuguaccucu uggucuuuga auaaagccug aguaggaagu cuagaaaaaa aaaaaaaaaa     4380

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4440

aaaa                                                                  4444


