                         SEQUENCE LISTING

<110>  Janssen Pharmaceuticals Inc.
 
<120>  SARS-CoV-2 Vaccines

<130>  JPI6049WOPCT1

<150>  US 63/023,160
<151>  2020-05-11

<160>  31    

<170>  PatentIn version 3.5

<210>  1
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COR200007 Peptide

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Gly Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  2
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COR200009 Peptide

<400>  2

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Gln Cys Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Lys Val Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser 
    1235                 1240                 1245             


Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys 
    1250                 1255                 1260             


Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys 
    1265                 1270                 1275             


Leu His  Tyr Thr 
    1280         


<210>  3
<211>  1282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COR200010 Peptide

<400>  3

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Gln Cys Val Asn Leu Thr Thr Arg Thr Gln 
            20                  25                  30          


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
        35                  40                  45              


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
    50                  55                  60                  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
65                  70                  75                  80  


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
                85                  90                  95      


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
            100                 105                 110         


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
        115                 120                 125             


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
    130                 135                 140                 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
145                 150                 155                 160 


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
                165                 170                 175     


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
            180                 185                 190         


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
        195                 200                 205             


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
    210                 215                 220                 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
225                 230                 235                 240 


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
                245                 250                 255     


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
            260                 265                 270         


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
        275                 280                 285             


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
    290                 295                 300                 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
305                 310                 315                 320 


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
                325                 330                 335     


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
            340                 345                 350         


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
        355                 360                 365             


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
    370                 375                 380                 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
385                 390                 395                 400 


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
                405                 410                 415     


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
            420                 425                 430         


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
        435                 440                 445             


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
    450                 455                 460                 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
465                 470                 475                 480 


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
                485                 490                 495     


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
            500                 505                 510         


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
        515                 520                 525             


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
    530                 535                 540                 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
545                 550                 555                 560 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
                565                 570                 575     


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
            580                 585                 590         


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
        595                 600                 605             


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
    610                 615                 620                 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
625                 630                 635                 640 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
                645                 650                 655     


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
            660                 665                 670         


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
        675                 680                 685             


Ser Pro Ser Arg Ala Gly Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
    690                 695                 700                 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
705                 710                 715                 720 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
                725                 730                 735     


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
            740                 745                 750         


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
        755                 760                 765             


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
    770                 775                 780                 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
785                 790                 795                 800 


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
                805                 810                 815     


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
            820                 825                 830         


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
        835                 840                 845             


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
    850                 855                 860                 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
865                 870                 875                 880 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
                885                 890                 895     


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
            900                 905                 910         


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
        915                 920                 925             


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
    930                 935                 940                 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
945                 950                 955                 960 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
                965                 970                 975     


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
            980                 985                 990         


Leu Asp Pro Pro Glu Ala Glu Val  Gln Ile Asp Arg Leu  Ile Thr Gly 
        995                 1000                 1005             


Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr Gln Gln  Leu Ile Arg 
    1010                 1015                 1020             


Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu Ala Ala  Thr Lys Met 
    1025                 1030                 1035             


Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg Val Asp  Phe Cys Gly 
    1040                 1045                 1050             


Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln Ser Ala  Pro His Gly 
    1055                 1060                 1065             


Val Val  Phe Leu His Val Thr  Tyr Val Pro Ala Gln  Glu Lys Asn 
    1070                 1075                 1080             


Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp Gly Lys  Ala His Phe 
    1085                 1090                 1095             


Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly Thr His  Trp Phe Val 
    1100                 1105                 1110             


Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile Ile Thr  Thr Asp Asn 
    1115                 1120                 1125             


Thr Phe  Val Ser Gly Asn Cys  Asp Val Val Ile Gly  Ile Val Asn 
    1130                 1135                 1140             


Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu Leu Asp  Ser Phe Lys 
    1145                 1150                 1155             


Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His Thr Ser  Pro Asp Val 
    1160                 1165                 1170             


Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala Ser Val  Val Asn Ile 
    1175                 1180                 1185             


Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val Ala Lys  Asn Leu Asn 
    1190                 1195                 1200             


Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly Lys Tyr  Glu Gln Tyr 
    1205                 1210                 1215             


Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly Phe Ile  Ala Gly Leu 
    1220                 1225                 1230             


Ile Ala  Ile Val Met Val Thr  Ile Met Leu Cys Cys  Met Thr Ser 
    1235                 1240                 1245             


Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser Cys Gly  Ser Cys Cys 
    1250                 1255                 1260             


Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val Leu Lys  Gly Val Lys 
    1265                 1270                 1275             


Leu His  Tyr Thr 
    1280         


<210>  4
<211>  1304
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  COR200018 Peptide

<400>  4

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Ala Ser Gln Glu Ile His Ala Arg Phe Arg Arg 
            20                  25                  30          


Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn 
        35                  40                  45              


Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
    50                  55                  60                  


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
65                  70                  75                  80  


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
                85                  90                  95      


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn 
            100                 105                 110         


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
        115                 120                 125             


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
    130                 135                 140                 


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
145                 150                 155                 160 


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
                165                 170                 175     


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
            180                 185                 190         


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
        195                 200                 205             


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
    210                 215                 220                 


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
225                 230                 235                 240 


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
                245                 250                 255     


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
            260                 265                 270         


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
        275                 280                 285             


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
    290                 295                 300                 


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
305                 310                 315                 320 


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
                325                 330                 335     


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
            340                 345                 350         


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
        355                 360                 365             


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
    370                 375                 380                 


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
385                 390                 395                 400 


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
                405                 410                 415     


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
            420                 425                 430         


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
        435                 440                 445             


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
    450                 455                 460                 


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
465                 470                 475                 480 


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
                485                 490                 495     


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
            500                 505                 510         


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
        515                 520                 525             


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
    530                 535                 540                 


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
545                 550                 555                 560 


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
                565                 570                 575     


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
            580                 585                 590         


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
        595                 600                 605             


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
    610                 615                 620                 


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
625                 630                 635                 640 


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
                645                 650                 655     


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
            660                 665                 670         


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
        675                 680                 685             


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
    690                 695                 700                 


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
705                 710                 715                 720 


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
                725                 730                 735     


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
            740                 745                 750         


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp 
        755                 760                 765             


Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu 
    770                 775                 780                 


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
785                 790                 795                 800 


Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
                805                 810                 815     


Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn 
            820                 825                 830         


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
        835                 840                 845             


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
    850                 855                 860                 


Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu 
865                 870                 875                 880 


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
                885                 890                 895     


Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr 
            900                 905                 910         


Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
        915                 920                 925             


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
    930                 935                 940                 


Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser 
945                 950                 955                 960 


Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu 
                965                 970                 975     


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
            980                 985                 990         


Leu Val Lys Gln Leu Ser Ser Asn  Phe Gly Ala Ile Ser  Ser Val Leu 
        995                 1000                 1005             


Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val Glu Ala  Glu Val Gln 
    1010                 1015                 1020             


Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln Ser Leu  Gln Thr Tyr 
    1025                 1030                 1035             


Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu Ile Arg  Ala Ser Ala 
    1040                 1045                 1050             


Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys Val Leu  Gly Gln Ser 
    1055                 1060                 1065             


Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr His Leu  Met Ser Phe 
    1070                 1075                 1080             


Pro Gln  Ser Ala Pro His Gly  Val Val Phe Leu His  Val Thr Tyr 
    1085                 1090                 1095             


Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr Ala Pro  Ala Ile Cys 
    1100                 1105                 1110             


His Asp  Gly Lys Ala His Phe  Pro Arg Glu Gly Val  Phe Val Ser 
    1115                 1120                 1125             


Asn Gly  Thr His Trp Phe Val  Thr Gln Arg Asn Phe  Tyr Glu Pro 
    1130                 1135                 1140             


Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val Ser Gly  Asn Cys Asp 
    1145                 1150                 1155             


Val Val  Ile Gly Ile Val Asn  Asn Thr Val Tyr Asp  Pro Leu Gln 
    1160                 1165                 1170             


Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu Asp Lys  Tyr Phe Lys 
    1175                 1180                 1185             


Asn His  Thr Ser Pro Asp Val  Asp Leu Gly Asp Ile  Ser Gly Ile 
    1190                 1195                 1200             


Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu Ile Asp  Arg Leu Asn 
    1205                 1210                 1215             


Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu Ile Asp  Leu Gln Glu 
    1220                 1225                 1230             


Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp Pro Trp  Tyr Ile Trp 
    1235                 1240                 1245             


Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile Val Met  Val Thr Ile 
    1250                 1255                 1260             


Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser Cys Leu  Lys Gly Cys 
    1265                 1270                 1275             


Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp Glu Asp  Asp Ser Glu 
    1280                 1285                 1290             


Pro Val  Leu Lys Gly Val Lys  Leu His Tyr Thr 
    1295                 1300                 


<210>  5
<211>  3819
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COR200007 Nucleotide

<400>  5
atgttcgtgt ttctggtact gctccccctc gtctccagtc aatgcgtgaa cctgaccaca       60

agaacccagc tgcctccagc ctacaccaac agctttacca gaggcgtgta ctaccccgac      120

aaggtgttca gatccagcgt gctgcactct acccaggacc tgttcctgcc tttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gagattcgac      240

aaccccgtgc tgcccttcaa cgacggggtg tactttgcca gcaccgagaa gtccaacatc      300

atcagaggct ggatcttcgg caccacactg gacagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actatcacaa gaacaacaag agctggatgg aaagcgagtt ccgggtgtac      480

agcagcgcca acaactgcac ctttgaatac gtgtcccagc ctttcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaagatct acagcaagca cacccctatc aacctcgtgc gggatctgcc tcagggcttc      660

tctgctctgg aacccctggt ggatctgccc atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cctggcgata gcagcagcgg atggacagct      780

ggtgccgccg cttactatgt gggctacctg cagcctagaa cctttctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctgg atcctctgag cgagacaaag      900

tgcaccctga agtccttcac cgtggaaaag ggcatctacc agaccagcaa cttccgggtg      960

cagcccaccg aatccatcgt gcggttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccaccagatt cgcctctgtg tacgcctgga accggaagcg gatcagcaat     1080

tgcgtggccg actactccgt gctgtacaac tccgccagct tcagcacctt caagtgctac     1140

ggcgtgtccc ctaccaagct gaacgacctg tgcttcacaa acgtgtacgc cgacagcttc     1200

gtgatccggg gagatgaagt gcggcagatt gcccctggac agactggcaa gatcgccgac     1260

tacaactaca agctgcccga cgacttcacc ggctgtgtga ttgcctggaa cagcaacaac     1320

ctggactcca aagtcggcgg caactacaat tacctgtacc ggctgttccg gaagtccaat     1380

ctgaagccct tcgagcggga catctccacc gagatctatc aggccggcag caccccttgt     1440

aacggcgtgg aaggcttcaa ctgctacttc ccactgcagt cctacggctt tcagcccaca     1500

aatggcgtgg gctatcagcc ctacagagtg gtggtgctga gcttcgaact gctgcatgcc     1560

cctgccacag tgtgcggccc taagaaaagc accaatctcg tgaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggcaccggc gtgctgacag agagcaacaa gaagttcctg     1680

ccattccagc agtttggccg ggatatcgcc gataccacag acgccgttag agatccccag     1740

acactggaaa tcctggacat caccccttgc agcttcggcg gagtgtctgt gatcacccct     1800

ggcaccaaca ccagcaatca ggtggcagtg ctgtaccagg acgtgaactg taccgaagtg     1860

cccgtggcca ttcacgccga tcagctgaca cctacatggc gggtgtactc caccggcagc     1920

aatgtgtttc agaccagagc cggctgtctg atcggagccg agcacgtgaa caatagctac     1980

gagtgcgaca tccccatcgg cgctggcatc tgtgccagct accagacaca gacaaacagc     2040

cccagcagag ccggatctgt ggccagccag agcatcattg cctacacaat gtctctgggc     2100

gccgagaaca gcgtggccta ctccaacaac tctatcgcta tccccaccaa cttcaccatc     2160

agcgtgacca cagagatcct gcctgtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gcgattccac cgagtgctcc aacctgctgc tgcagtacgg cagcttctgc     2280

acccagctga atagagccct gacagggatc gccgtggaac aggacaagaa cacccaagag     2340

gtgttcgccc aagtgaagca gatctacaag acccctccta tcaaggactt cggcggcttc     2400

aatttcagcc agattctgcc cgatcctagc aagcccagca agcggagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggcttca tcaagcagta tggcgattgt     2520

ctgggcgaca ttgccgccag ggatctgatt tgcgcccaga agtttaacgg actgacagtg     2580

ctgcctcctc tgctgaccga tgagatgatc gcccagtaca catctgccct gctggccggc     2640

acaatcacaa gcggctggac atttggagct ggcgccgctc tgcagatccc ctttgctatg     2700

cagatggcct accggttcaa cggcatcgga gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga tccaggacag cctgagcagc     2820

acagcaagcg ccctgggaaa gctgcaggac gtggtcaacc agaatgccca ggcactgaac     2880

accctggtca agcagctgtc ctccaacttc ggcgccatca gctctgtgct gaacgatatc     2940

ctgagcagac tggaccctcc tgaggccgag gtgcagatcg acagactgat caccggaagg     3000

ctgcagtccc tgcagaccta cgttacccag cagctgatca gagccgccga gattagagcc     3060

tctgccaatc tggccgccac caagatgtct gagtgtgtgc tgggccagag caagagagtg     3120

gacttttgcg gcaagggcta ccacctgatg agcttccctc agtctgcccc tcacggcgtg     3180

gtgtttctgc acgtgacata tgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggcaaagc ccactttcct agagaaggcg tgttcgtgtc caacggcacc     3300

cattggttcg tgacacagcg gaacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtgtctg gcaactgcga cgtcgtgatc ggcattgtga acaataccgt gtacgaccct     3420

ctgcagcccg agctggacag cttcaaagag gaactggaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg cgatatcagc ggaatcaatg ccagcgtcgt gaacatccag     3540

aaagagatcg accggctgaa cgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caagaactgg gaaaatacga gcagtacatc aagtggcctt ggtacatctg gctgggcttt     3660

atcgccggac tgattgccat cgtgatggtc acaatcatgc tgtgttgcat gaccagctgc     3720

tgtagctgcc tgaagggctg ttgtagctgt ggcagctgct gcaagttcga cgaggacgat     3780

tctgagcccg tgctgaaggg cgtgaaactg cactacaca                            3819


<210>  6
<211>  3846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COR200009 Nucleotide

<400>  6
atggacgcta tgaagagggg cctgtgctgt gtgctgctgc tgtgcggagc tgtgtttgtg       60

tctgctcaat gcgtgaacct gaccacaaga acccagctgc ctccagccta caccaacagc      120

tttaccagag gcgtgtacta ccccgacaag gtgttcagat ccagcgtgct gcactctacc      180

caggacctgt tcctgccttt cttcagcaac gtgacctggt tccacgccat ccacgtgtcc      240

ggcaccaatg gcaccaagag attcgacaac cccgtgctgc ccttcaacga cggggtgtac      300

tttgccagca ccgagaagtc caacatcatc agaggctgga tcttcggcac cacactggac      360

agcaagaccc agagcctgct gatcgtgaac aacgccacca acgtggtcat caaagtgtgc      420

gagttccagt tctgcaacga ccccttcctg ggcgtctact atcacaagaa caacaagagc      480

tggatggaaa gcgagttccg ggtgtacagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagcctt tcctgatgga cctggaaggc aagcagggca acttcaagaa cctgcgcgag      600

ttcgtgttca agaacatcga cggctacttc aagatctaca gcaagcacac ccctatcaac      660

ctcgtgcggg atctgcctca gggcttctct gctctggaac ccctggtgga tctgcccatc      720

ggcatcaaca tcacccggtt tcagacactg ctggccctgc acagaagcta cctgacacct      780

ggcgatagca gcagcggatg gacagctggt gccgccgctt actatgtggg ctacctgcag      840

cctagaacct ttctgctgaa gtacaacgag aacggcacca tcaccgacgc cgtggattgt      900

gctctggatc ctctgagcga gacaaagtgc accctgaagt ccttcaccgt ggaaaagggc      960

atctaccaga ccagcaactt ccgggtgcag cccaccgaat ccatcgtgcg gttccccaat     1020

atcaccaatc tgtgcccctt cggcgaggtg ttcaatgcca ccagattcgc ctctgtgtac     1080

gcctggaacc ggaagcggat cagcaattgc gtggccgact actccgtgct gtacaactcc     1140

gccagcttca gcaccttcaa gtgctacggc gtgtccccta ccaagctgaa cgacctgtgc     1200

ttcacaaacg tgtacgccga cagcttcgtg atccggggag atgaagtgcg gcagattgcc     1260

cctggacaga ctggcaagat cgccgactac aactacaagc tgcccgacga cttcaccggc     1320

tgtgtgattg cctggaacag caacaacctg gactccaaag tcggcggcaa ctacaattac     1380

ctgtaccggc tgttccggaa gtccaatctg aagcccttcg agcgggacat ctccaccgag     1440

atctatcagg ccggcagcac cccttgtaac ggcgtggaag gcttcaactg ctacttccca     1500

ctgcagtcct acggctttca gcccacaaat ggcgtgggct atcagcccta cagagtggtg     1560

gtgctgagct tcgaactgct gcatgcccct gccacagtgt gcggccctaa gaaaagcacc     1620

aatctcgtga agaacaaatg cgtgaacttc aacttcaacg gcctgaccgg caccggcgtg     1680

ctgacagaga gcaacaagaa gttcctgcca ttccagcagt ttggccggga tatcgccgat     1740

accacagacg ccgttagaga tccccagaca ctggaaatcc tggacatcac cccttgcagc     1800

ttcggcggag tgtctgtgat cacccctggc accaacacca gcaatcaggt ggcagtgctg     1860

taccaggacg tgaactgtac cgaagtgccc gtggccattc acgccgatca gctgacacct     1920

acatggcggg tgtactccac cggcagcaat gtgtttcaga ccagagccgg ctgtctgatc     1980

ggagccgagc acgtgaacaa tagctacgag tgcgacatcc ccatcggcgc tggcatctgt     2040

gccagctacc agacacagac aaacagcccc agacgggcca gatctgtggc cagccagagc     2100

atcattgcct acacaatgtc tctgggcgcc gagaacagcg tggcctactc caacaactct     2160

atcgctatcc ccaccaactt caccatcagc gtgaccacag agatcctgcc tgtgtccatg     2220

accaagacca gcgtggactg caccatgtac atctgcggcg attccaccga gtgctccaac     2280

ctgctgctgc agtacggcag cttctgcacc cagctgaata gagccctgac agggatcgcc     2340

gtggaacagg acaagaacac ccaagaggtg ttcgcccaag tgaagcagat ctacaagacc     2400

cctcctatca aggacttcgg cggcttcaat ttcagccaga ttctgcccga tcctagcaag     2460

cccagcaagc ggagcttcat cgaggacctg ctgttcaaca aagtgacact ggccgacgcc     2520

ggcttcatca agcagtatgg cgattgtctg ggcgacattg ccgccaggga tctgatttgc     2580

gcccagaagt ttaacggact gacagtgctg cctcctctgc tgaccgatga gatgatcgcc     2640

cagtacacat ctgccctgct ggccggcaca atcacaagcg gctggacatt tggagctggc     2700

gccgctctgc agatcccctt tgctatgcag atggcctacc ggttcaacgg catcggagtg     2760

acccagaatg tgctgtacga gaaccagaag ctgatcgcca accagttcaa cagcgccatc     2820

ggcaagatcc aggacagcct gagcagcaca gcaagcgccc tgggaaagct gcaggacgtg     2880

gtcaaccaga atgcccaggc actgaacacc ctggtcaagc agctgtcctc caacttcggc     2940

gccatcagct ctgtgctgaa cgatatcctg agcagactgg acaaggtgga agccgaggtg     3000

cagatcgaca gactgatcac cggaaggctg cagtccctgc agacctacgt tacccagcag     3060

ctgatcagag ccgccgagat tagagcctct gccaatctgg ccgccaccaa gatgtctgag     3120

tgtgtgctgg gccagagcaa gagagtggac ttttgcggca agggctacca cctgatgagc     3180

ttccctcagt ctgcccctca cggcgtggtg tttctgcacg tgacatatgt gcccgctcaa     3240

gagaagaatt tcaccaccgc tccagccatc tgccacgacg gcaaagccca ctttcctaga     3300

gaaggcgtgt tcgtgtccaa cggcacccat tggttcgtga cacagcggaa cttctacgag     3360

ccccagatca tcaccaccga caacaccttc gtgtctggca actgcgacgt cgtgatcggc     3420

attgtgaaca ataccgtgta cgaccctctg cagcccgagc tggacagctt caaagaggaa     3480

ctggacaagt actttaagaa ccacacaagc cccgacgtgg acctgggcga tatcagcgga     3540

atcaatgcca gcgtcgtgaa catccagaaa gagatcgacc ggctgaacga ggtggccaag     3600

aatctgaacg agagcctgat cgacctgcaa gaactgggaa aatacgagca gtacatcaag     3660

tggccttggt acatctggct gggctttatc gccggactga ttgccatcgt gatggtcaca     3720

atcatgctgt gttgcatgac cagctgctgt agctgcctga agggctgttg tagctgtggc     3780

agctgctgca agttcgacga ggacgattct gagcccgtgc tgaagggcgt gaaactgcac     3840

tacaca                                                                3846


<210>  7
<211>  3846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COR200010 Nucleotide

<400>  7
atggacgcta tgaagagggg cctgtgctgt gtgctgctgc tgtgcggagc tgtgtttgtg       60

tctgctcaat gcgtgaacct gaccacaaga acccagctgc ctccagccta caccaacagc      120

tttaccagag gcgtgtacta ccccgacaag gtgttcagat ccagcgtgct gcactctacc      180

caggacctgt tcctgccttt cttcagcaac gtgacctggt tccacgccat ccacgtgtcc      240

ggcaccaatg gcaccaagag attcgacaac cccgtgctgc ccttcaacga cggggtgtac      300

tttgccagca ccgagaagtc caacatcatc agaggctgga tcttcggcac cacactggac      360

agcaagaccc agagcctgct gatcgtgaac aacgccacca acgtggtcat caaagtgtgc      420

gagttccagt tctgcaacga ccccttcctg ggcgtctact atcacaagaa caacaagagc      480

tggatggaaa gcgagttccg ggtgtacagc agcgccaaca actgcacctt tgaatacgtg      540

tcccagcctt tcctgatgga cctggaaggc aagcagggca acttcaagaa cctgcgcgag      600

ttcgtgttca agaacatcga cggctacttc aagatctaca gcaagcacac ccctatcaac      660

ctcgtgcggg atctgcctca gggcttctct gctctggaac ccctggtgga tctgcccatc      720

ggcatcaaca tcacccggtt tcagacactg ctggccctgc acagaagcta cctgacacct      780

ggcgatagca gcagcggatg gacagctggt gccgccgctt actatgtggg ctacctgcag      840

cctagaacct ttctgctgaa gtacaacgag aacggcacca tcaccgacgc cgtggattgt      900

gctctggatc ctctgagcga gacaaagtgc accctgaagt ccttcaccgt ggaaaagggc      960

atctaccaga ccagcaactt ccgggtgcag cccaccgaat ccatcgtgcg gttccccaat     1020

atcaccaatc tgtgcccctt cggcgaggtg ttcaatgcca ccagattcgc ctctgtgtac     1080

gcctggaacc ggaagcggat cagcaattgc gtggccgact actccgtgct gtacaactcc     1140

gccagcttca gcaccttcaa gtgctacggc gtgtccccta ccaagctgaa cgacctgtgc     1200

ttcacaaacg tgtacgccga cagcttcgtg atccggggag atgaagtgcg gcagattgcc     1260

cctggacaga ctggcaagat cgccgactac aactacaagc tgcccgacga cttcaccggc     1320

tgtgtgattg cctggaacag caacaacctg gactccaaag tcggcggcaa ctacaattac     1380

ctgtaccggc tgttccggaa gtccaatctg aagcccttcg agcgggacat ctccaccgag     1440

atctatcagg ccggcagcac cccttgtaac ggcgtggaag gcttcaactg ctacttccca     1500

ctgcagtcct acggctttca gcccacaaat ggcgtgggct atcagcccta cagagtggtg     1560

gtgctgagct tcgaactgct gcatgcccct gccacagtgt gcggccctaa gaaaagcacc     1620

aatctcgtga agaacaaatg cgtgaacttc aacttcaacg gcctgaccgg caccggcgtg     1680

ctgacagaga gcaacaagaa gttcctgcca ttccagcagt ttggccggga tatcgccgat     1740

accacagacg ccgttagaga tccccagaca ctggaaatcc tggacatcac cccttgcagc     1800

ttcggcggag tgtctgtgat cacccctggc accaacacca gcaatcaggt ggcagtgctg     1860

taccaggacg tgaactgtac cgaagtgccc gtggccattc acgccgatca gctgacacct     1920

acatggcggg tgtactccac cggcagcaat gtgtttcaga ccagagccgg ctgtctgatc     1980

ggagccgagc acgtgaacaa tagctacgag tgcgacatcc ccatcggcgc tggcatctgt     2040

gccagctacc agacacagac aaacagcccc agcagagccg gatctgtggc cagccagagc     2100

atcattgcct acacaatgtc tctgggcgcc gagaacagcg tggcctactc caacaactct     2160

atcgctatcc ccaccaactt caccatcagc gtgaccacag agatcctgcc tgtgtccatg     2220

accaagacca gcgtggactg caccatgtac atctgcggcg attccaccga gtgctccaac     2280

ctgctgctgc agtacggcag cttctgcacc cagctgaata gagccctgac agggatcgcc     2340

gtggaacagg acaagaacac ccaagaggtg ttcgcccaag tgaagcagat ctacaagacc     2400

cctcctatca aggacttcgg cggcttcaat ttcagccaga ttctgcccga tcctagcaag     2460

cccagcaagc ggagcttcat cgaggacctg ctgttcaaca aagtgacact ggccgacgcc     2520

ggcttcatca agcagtatgg cgattgtctg ggcgacattg ccgccaggga tctgatttgc     2580

gcccagaagt ttaacggact gacagtgctg cctcctctgc tgaccgatga gatgatcgcc     2640

cagtacacat ctgccctgct ggccggcaca atcacaagcg gctggacatt tggagctggc     2700

gccgctctgc agatcccctt tgctatgcag atggcctacc ggttcaacgg catcggagtg     2760

acccagaatg tgctgtacga gaaccagaag ctgatcgcca accagttcaa cagcgccatc     2820

ggcaagatcc aggacagcct gagcagcaca gcaagcgccc tgggaaagct gcaggacgtg     2880

gtcaaccaga atgcccaggc actgaacacc ctggtcaagc agctgtcctc caacttcggc     2940

gccatcagct ctgtgctgaa cgatatcctg agcagactgg accctcctga ggccgaggtg     3000

cagatcgaca gactgatcac cggaaggctg cagtccctgc agacctacgt tacccagcag     3060

ctgatcagag ccgccgagat tagagcctct gccaatctgg ccgccaccaa gatgtctgag     3120

tgtgtgctgg gccagagcaa gagagtggac ttttgcggca agggctacca cctgatgagc     3180

ttccctcagt ctgcccctca cggcgtggtg tttctgcacg tgacatatgt gcccgctcaa     3240

gagaagaatt tcaccaccgc tccagccatc tgccacgacg gcaaagccca ctttcctaga     3300

gaaggcgtgt tcgtgtccaa cggcacccat tggttcgtga cacagcggaa cttctacgag     3360

ccccagatca tcaccaccga caacaccttc gtgtctggca actgcgacgt cgtgatcggc     3420

attgtgaaca ataccgtgta cgaccctctg cagcccgagc tggacagctt caaagaggaa     3480

ctggacaagt actttaagaa ccacacaagc cccgacgtgg acctgggcga tatcagcgga     3540

atcaatgcca gcgtcgtgaa catccagaaa gagatcgacc ggctgaacga ggtggccaag     3600

aatctgaacg agagcctgat cgacctgcaa gaactgggaa aatacgagca gtacatcaag     3660

tggccttggt acatctggct gggctttatc gccggactga ttgccatcgt gatggtcaca     3720

atcatgctgt gttgcatgac cagctgctgt agctgcctga agggctgttg tagctgtggc     3780

agctgctgca agttcgacga ggacgattct gagcccgtgc tgaagggcgt gaaactgcac     3840

tacaca                                                                3846


<210>  8
<211>  3912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  COR200018 Nucleotide

<400>  8
atggacgcta tgaagagggg cctgtgctgt gtgctgctgc tgtgcggagc tgtgtttgtg       60

tctgctagcc aagagatcca cgccagattt cggagattcg tgtttctggt gctgctgcct      120

ctggtgtcca gccaatgcgt gaacctgacc acaagaaccc agctgcctcc agcctacacc      180

aacagcttta ccagaggcgt gtactacccc gacaaggtgt tcagatccag cgtgctgcac      240

tctacccagg acctgttcct gcctttcttc agcaacgtga cctggttcca cgccatccac      300

gtgtccggca ccaatggcac caagagattc gacaaccccg tgctgccctt caacgacggg      360

gtgtactttg ccagcaccga gaagtccaac atcatcagag gctggatctt cggcaccaca      420

ctggacagca agacccagag cctgctgatc gtgaacaacg ccaccaacgt ggtcatcaaa      480

gtgtgcgagt tccagttctg caacgacccc ttcctgggcg tctactatca caagaacaac      540

aagagctgga tggaaagcga gttccgggtg tacagcagcg ccaacaactg cacctttgaa      600

tacgtgtccc agcctttcct gatggacctg gaaggcaagc agggcaactt caagaacctg      660

cgcgagttcg tgttcaagaa catcgacggc tacttcaaga tctacagcaa gcacacccct      720

atcaacctcg tgcgggatct gcctcagggc ttctctgctc tggaacccct ggtggatctg      780

cccatcggca tcaacatcac ccggtttcag acactgctgg ccctgcacag aagctacctg      840

acacctggcg atagcagcag cggatggaca gctggtgccg ccgcttacta tgtgggctac      900

ctgcagccta gaacctttct gctgaagtac aacgagaacg gcaccatcac cgacgccgtg      960

gattgtgctc tggatcctct gagcgagaca aagtgcaccc tgaagtcctt caccgtggaa     1020

aagggcatct accagaccag caacttccgg gtgcagccca ccgaatccat cgtgcggttc     1080

cccaatatca ccaatctgtg ccccttcggc gaggtgttca atgccaccag attcgcctct     1140

gtgtacgcct ggaaccggaa gcggatcagc aattgcgtgg ccgactactc cgtgctgtac     1200

aactccgcca gcttcagcac cttcaagtgc tacggcgtgt cccctaccaa gctgaacgac     1260

ctgtgcttca caaacgtgta cgccgacagc ttcgtgatcc ggggagatga agtgcggcag     1320

attgcccctg gacagactgg caagatcgcc gactacaact acaagctgcc cgacgacttc     1380

accggctgtg tgattgcctg gaacagcaac aacctggact ccaaagtcgg cggcaactac     1440

aattacctgt accggctgtt ccggaagtcc aatctgaagc ccttcgagcg ggacatctcc     1500

accgagatct atcaggccgg cagcacccct tgtaacggcg tggaaggctt caactgctac     1560

ttcccactgc agtcctacgg ctttcagccc acaaatggcg tgggctatca gccctacaga     1620

gtggtggtgc tgagcttcga actgctgcat gcccctgcca cagtgtgcgg ccctaagaaa     1680

agcaccaatc tcgtgaagaa caaatgcgtg aacttcaact tcaacggcct gaccggcacc     1740

ggcgtgctga cagagagcaa caagaagttc ctgccattcc agcagtttgg ccgggatatc     1800

gccgatacca cagacgccgt tagagatccc cagacactgg aaatcctgga catcacccct     1860

tgcagcttcg gcggagtgtc tgtgatcacc cctggcacca acaccagcaa tcaggtggca     1920

gtgctgtacc aggacgtgaa ctgtaccgaa gtgcccgtgg ccattcacgc cgatcagctg     1980

acacctacat ggcgggtgta ctccaccggc agcaatgtgt ttcagaccag agccggctgt     2040

ctgatcggag ccgagcacgt gaacaatagc tacgagtgcg acatccccat cggcgctggc     2100

atctgtgcca gctaccagac acagacaaac agccccagac gggccagatc tgtggccagc     2160

cagagcatca ttgcctacac aatgtctctg ggcgccgaga acagcgtggc ctactccaac     2220

aactctatcg ctatccccac caacttcacc atcagcgtga ccacagagat cctgcctgtg     2280

tccatgacca agaccagcgt ggactgcacc atgtacatct gcggcgattc caccgagtgc     2340

tccaacctgc tgctgcagta cggcagcttc tgcacccagc tgaatagagc cctgacaggg     2400

atcgccgtgg aacaggacaa gaacacccaa gaggtgttcg cccaagtgaa gcagatctac     2460

aagacccctc ctatcaagga cttcggcggc ttcaatttca gccagattct gcccgatcct     2520

agcaagccca gcaagcggag cttcatcgag gacctgctgt tcaacaaagt gacactggcc     2580

gacgccggct tcatcaagca gtatggcgat tgtctgggcg acattgccgc cagggatctg     2640

atttgcgccc agaagtttaa cggactgaca gtgctgcctc ctctgctgac cgatgagatg     2700

atcgcccagt acacatctgc cctgctggcc ggcacaatca caagcggctg gacatttgga     2760

gctggcgccg ctctgcagat cccctttgct atgcagatgg cctaccggtt caacggcatc     2820

ggagtgaccc agaatgtgct gtacgagaac cagaagctga tcgccaacca gttcaacagc     2880

gccatcggca agatccagga cagcctgagc agcacagcaa gcgccctggg aaagctgcag     2940

gacgtggtca accagaatgc ccaggcactg aacaccctgg tcaagcagct gtcctccaac     3000

ttcggcgcca tcagctctgt gctgaacgat atcctgagca gactggacaa ggtggaagcc     3060

gaggtgcaga tcgacagact gatcaccgga aggctgcagt ccctgcagac ctacgttacc     3120

cagcagctga tcagagccgc cgagattaga gcctctgcca atctggccgc caccaagatg     3180

tctgagtgtg tgctgggcca gagcaagaga gtggactttt gcggcaaggg ctaccacctg     3240

atgagcttcc ctcagtctgc ccctcacggc gtggtgtttc tgcacgtgac atatgtgccc     3300

gctcaagaga agaatttcac caccgctcca gccatctgcc acgacggcaa agcccacttt     3360

cctagagaag gcgtgttcgt gtccaacggc acccattggt tcgtgacaca gcggaacttc     3420

tacgagcccc agatcatcac caccgacaac accttcgtgt ctggcaactg cgacgtcgtg     3480

atcggcattg tgaacaatac cgtgtacgac cctctgcagc ccgagctgga cagcttcaaa     3540

gaggaactgg acaagtactt taagaaccac acaagccccg acgtggacct gggcgatatc     3600

agcggaatca atgccagcgt cgtgaacatc cagaaagaga tcgaccggct gaacgaggtg     3660

gccaagaatc tgaacgagag cctgatcgac ctgcaagaac tgggaaaata cgagcagtac     3720

atcaagtggc cttggtacat ctggctgggc tttatcgccg gactgattgc catcgtgatg     3780

gtcacaatca tgctgtgttg catgaccagc tgctgtagct gcctgaaggg ctgttgtagc     3840

tgtggcagct gctgcaagtt cgacgaggac gattctgagc ccgtgctgaa gggcgtgaaa     3900

ctgcactaca ca                                                         3912


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  furin site amino acid sequence

<400>  9

Arg Ala Arg Arg 
1               


<210>  10
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant furin site amino acid sequence

<400>  10

Ser Arg Ala Gly 
1               


<210>  11
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insert for SMARRT-COV2 1158

<400>  11
atgttcgtgt ttctggtgct gctgcctctg gtgtccagcc aatgcgtgaa cctgaccaca       60

agaacccagc tgcctccagc ctacaccaac agctttacca gaggcgtgta ctaccccgac      120

aaggtgttca gatccagcgt gctgcactct acccaggacc tgttcctgcc tttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gagattcgac      240

aaccccgtgc tgcccttcaa cgacggggtg tactttgcca gcaccgagaa gtccaacatc      300

atcagaggct ggatcttcgg caccacactg gacagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actatcacaa gaacaacaag agctggatgg aaagcgagtt ccgggtgtac      480

agcagcgcca acaactgcac ctttgaatac gtgtcccagc ctttcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaagatct acagcaagca cacccctatc aacctcgtgc gggatctgcc tcagggcttc      660

tctgctctgg aacccctggt ggatctgccc atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cctggcgata gcagcagcgg atggacagct      780

ggtgccgccg cttactatgt gggctacctg cagcctagaa cctttctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctgg atcctctgag cgagacaaag      900

tgcaccctga agtccttcac cgtggaaaag ggcatctacc agaccagcaa cttccgggtg      960

cagcccaccg aatccatcgt gcggttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccaccagatt cgcctctgtg tacgcctgga accggaagcg gatcagcaat     1080

tgcgtggccg actactccgt gctgtacaac tccgccagct tcagcacctt caagtgctac     1140

ggcgtgtccc ctaccaagct gaacgacctg tgcttcacaa acgtgtacgc cgacagcttc     1200

gtgatccggg gagatgaagt gcggcagatt gcccctggac agactggcaa gatcgccgac     1260

tacaactaca agctgcccga cgacttcacc ggctgtgtga ttgcctggaa cagcaacaac     1320

ctggactcca aagtcggcgg caactacaat tacctgtacc ggctgttccg gaagtccaat     1380

ctgaagccct tcgagcggga catctccacc gagatctatc aggccggcag caccccttgt     1440

aacggcgtgg aaggcttcaa ctgctacttc ccactgcagt cctacggctt tcagcccaca     1500

aatggcgtgg gctatcagcc ctacagagtg gtggtgctga gcttcgaact gctgcatgcc     1560

cctgccacag tgtgcggccc taagaaaagc accaatctcg tgaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggcaccggc gtgctgacag agagcaacaa gaagttcctg     1680

ccattccagc agtttggccg ggatatcgcc gataccacag acgccgttag agatccccag     1740

acactggaaa tcctggacat caccccttgc agcttcggcg gagtgtctgt gatcacccct     1800

ggcaccaaca ccagcaatca ggtggcagtg ctgtaccagg acgtgaactg taccgaagtg     1860

cccgtggcca ttcacgccga tcagctgaca cctacatggc gggtgtactc caccggcagc     1920

aatgtgtttc agaccagagc cggctgtctg atcggagccg agcacgtgaa caatagctac     1980

gagtgcgaca tccccatcgg cgctggcatc tgtgccagct accagacaca gacaaacagc     2040

cccagacggg ccagatctgt ggccagccag agcatcattg cctacacaat gtctctgggc     2100

gccgagaaca gcgtggccta ctccaacaac tctatcgcta tccccaccaa cttcaccatc     2160

agcgtgacca cagagatcct gcctgtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gcgattccac cgagtgctcc aacctgctgc tgcagtacgg cagcttctgc     2280

acccagctga atagagccct gacagggatc gccgtggaac aggacaagaa cacccaagag     2340

gtgttcgccc aagtgaagca gatctacaag acccctccta tcaaggactt cggcggcttc     2400

aatttcagcc agattctgcc cgatcctagc aagcccagca agcggagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggcttca tcaagcagta tggcgattgt     2520

ctgggcgaca ttgccgccag ggatctgatt tgcgcccaga agtttaacgg actgacagtg     2580

ctgcctcctc tgctgaccga tgagatgatc gcccagtaca catctgccct gctggccggc     2640

acaatcacaa gcggctggac atttggagct ggcgccgctc tgcagatccc ctttgctatg     2700

cagatggcct accggttcaa cggcatcgga gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga tccaggacag cctgagcagc     2820

acagcaagcg ccctgggaaa gctgcaggac gtggtcaacc agaatgccca ggcactgaac     2880

accctggtca agcagctgtc ctccaacttc ggcgccatca gctctgtgct gaacgatatc     2940

ctgagcagac tggacaaggt ggaagccgag gtgcagatcg acagactgat caccggaagg     3000

ctgcagtccc tgcagaccta cgttacccag cagctgatca gagccgccga gattagagcc     3060

tctgccaatc tggccgccac caagatgtct gagtgtgtgc tgggccagag caagagagtg     3120

gacttttgcg gcaagggcta ccacctgatg agcttccctc agtctgcccc tcacggcgtg     3180

gtgtttctgc acgtgactta tgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggcaaagc ccactttcct agagaaggcg tgttcgtgtc caacggcacc     3300

cattggttcg tgacacagcg gaacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtgtctg gcaactgcga cgtcgtgatc ggcattgtga acaataccgt gtacgaccct     3420

ctgcagcccg agctggacag cttcaaagag gaactggaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg cgatatcagc ggaatcaatg ccagcgtcgt gaacatccag     3540

aaagagatcg accggctgaa cgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caagaactgg gaaaatacga gcagtacatc aagtggcctt ggtacatctg gctgggcttt     3660

atcgccggac tgattgccat cgtgatggtc acaatcatgc tgtgttgcat gaccagctgc     3720

tgtagctgcc tgaagggctg ttgtagctgt ggcagctgct gcaagttcga cgaggacgat     3780

tctgagcccg tgctgaaggg cgtgaaactg cactacacat gataa                     3825


<210>  12
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insert for SMARRT-COV2 1158

<400>  12

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  13
<211>  3825
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Insert for SMARRT-COV2 1159

<400>  13
atgttcgtgt ttctggtgct gctgcctctg gtgtccagcc aatgcgtgaa cctgaccaca       60

agaacccagc tgcctccagc ctacaccaac agctttacca gaggcgtgta ctaccccgac      120

aaggtgttca gatccagcgt gctgcactct acccaggacc tgttcctgcc tttcttcagc      180

aacgtgacct ggttccacgc catccacgtg tccggcacca atggcaccaa gagattcgac      240

aaccccgtgc tgcccttcaa cgacggggtg tactttgcca gcaccgagaa gtccaacatc      300

atcagaggct ggatcttcgg caccacactg gacagcaaga cccagagcct gctgatcgtg      360

aacaacgcca ccaacgtggt catcaaagtg tgcgagttcc agttctgcaa cgaccccttc      420

ctgggcgtct actatcacaa gaacaacaag agctggatgg aaagcgagtt ccgggtgtac      480

agcagcgcca acaactgcac ctttgaatac gtgtcccagc ctttcctgat ggacctggaa      540

ggcaagcagg gcaacttcaa gaacctgcgc gagttcgtgt tcaagaacat cgacggctac      600

ttcaagatct acagcaagca cacccctatc aacctcgtgc gggatctgcc tcagggcttc      660

tctgctctgg aacccctggt ggatctgccc atcggcatca acatcacccg gtttcagaca      720

ctgctggccc tgcacagaag ctacctgaca cctggcgata gcagcagcgg atggacagct      780

ggtgccgccg cttactatgt gggctacctg cagcctagaa cctttctgct gaagtacaac      840

gagaacggca ccatcaccga cgccgtggat tgtgctctgg atcctctgag cgagacaaag      900

tgcaccctga agtccttcac cgtggaaaag ggcatctacc agaccagcaa cttccgggtg      960

cagcccaccg aatccatcgt gcggttcccc aatatcacca atctgtgccc cttcggcgag     1020

gtgttcaatg ccaccagatt cgcctctgtg tacgcctgga accggaagcg gatcagcaat     1080

tgcgtggccg actactccgt gctgtacaac tccgccagct tcagcacctt caagtgctac     1140

ggcgtgtccc ctaccaagct gaacgacctg tgcttcacaa acgtgtacgc cgacagcttc     1200

gtgatccggg gagatgaagt gcggcagatt gcccctggac agactggcaa gatcgccgac     1260

tacaactaca agctgcccga cgacttcacc ggctgtgtga ttgcctggaa cagcaacaac     1320

ctggactcca aagtcggcgg caactacaat tacctgtacc ggctgttccg gaagtccaat     1380

ctgaagccct tcgagcggga catctccacc gagatctatc aggccggcag caccccttgt     1440

aacggcgtgg aaggcttcaa ctgctacttc ccactgcagt cctacggctt tcagcccaca     1500

aatggcgtgg gctatcagcc ctacagagtg gtggtgctga gcttcgaact gctgcatgcc     1560

cctgccacag tgtgcggccc taagaaaagc accaatctcg tgaagaacaa atgcgtgaac     1620

ttcaacttca acggcctgac cggcaccggc gtgctgacag agagcaacaa gaagttcctg     1680

ccattccagc agtttggccg ggatatcgcc gataccacag acgccgttag agatccccag     1740

acactggaaa tcctggacat caccccttgc agcttcggcg gagtgtctgt gatcacccct     1800

ggcaccaaca ccagcaatca ggtggcagtg ctgtaccagg acgtgaactg taccgaagtg     1860

cccgtggcca ttcacgccga tcagctgaca cctacatggc gggtgtactc caccggcagc     1920

aatgtgtttc agaccagagc cggctgtctg atcggagccg agcacgtgaa caatagctac     1980

gagtgcgaca tccccatcgg cgctggcatc tgtgccagct accagacaca gacaaacagc     2040

cccagcagag ccggatctgt ggccagccag agcatcattg cctacacaat gtctctgggc     2100

gccgagaaca gcgtggccta ctccaacaac tctatcgcta tccccaccaa cttcaccatc     2160

agcgtgacca cagagatcct gcctgtgtcc atgaccaaga ccagcgtgga ctgcaccatg     2220

tacatctgcg gcgattccac cgagtgctcc aacctgctgc tgcagtacgg cagcttctgc     2280

acccagctga atagagccct gacagggatc gccgtggaac aggacaagaa cacccaagag     2340

gtgttcgccc aagtgaagca gatctacaag acccctccta tcaaggactt cggcggcttc     2400

aatttcagcc agattctgcc cgatcctagc aagcccagca agcggagctt catcgaggac     2460

ctgctgttca acaaagtgac actggccgac gccggcttca tcaagcagta tggcgattgt     2520

ctgggcgaca ttgccgccag ggatctgatt tgcgcccaga agtttaacgg actgacagtg     2580

ctgcctcctc tgctgaccga tgagatgatc gcccagtaca catctgccct gctggccggc     2640

acaatcacaa gcggctggac atttggagct ggcgccgctc tgcagatccc ctttgctatg     2700

cagatggcct accggttcaa cggcatcgga gtgacccaga atgtgctgta cgagaaccag     2760

aagctgatcg ccaaccagtt caacagcgcc atcggcaaga tccaggacag cctgagcagc     2820

acagcaagcg ccctgggaaa gctgcaggac gtggtcaacc agaatgccca ggcactgaac     2880

accctggtca agcagctgtc ctccaacttc ggcgccatca gctctgtgct gaacgatatc     2940

ctgagcagac tggaccctcc tgaggccgag gtgcagatcg acagactgat caccggaagg     3000

ctgcagtccc tgcagaccta cgttacccag cagctgatca gagccgccga gattagagcc     3060

tctgccaatc tggccgccac caagatgtct gagtgtgtgc tgggccagag caagagagtg     3120

gacttttgcg gcaagggcta ccacctgatg agcttccctc agtctgcccc tcacggcgtg     3180

gtgtttctgc acgtgactta tgtgcccgct caagagaaga atttcaccac cgctccagcc     3240

atctgccacg acggcaaagc ccactttcct agagaaggcg tgttcgtgtc caacggcacc     3300

cattggttcg tgacacagcg gaacttctac gagccccaga tcatcaccac cgacaacacc     3360

ttcgtgtctg gcaactgcga cgtcgtgatc ggcattgtga acaataccgt gtacgaccct     3420

ctgcagcccg agctggacag cttcaaagag gaactggaca agtactttaa gaaccacaca     3480

agccccgacg tggacctggg cgatatcagc ggaatcaatg ccagcgtcgt gaacatccag     3540

aaagagatcg accggctgaa cgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caagaactgg gaaaatacga gcagtacatc aagtggcctt ggtacatctg gctgggcttt     3660

atcgccggac tgattgccat cgtgatggtc acaatcatgc tgtgttgcat gaccagctgc     3720

tgtagctgcc tgaagggctg ttgtagctgt ggcagctgct gcaagttcga cgaggacgat     3780

tctgagcccg tgctgaaggg cgtgaaactg cactacacat gataa                     3825


<210>  14
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Insert for SMARRT-COV2 1159

<400>  14

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Gly Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  15
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide nucleotide sequence

<400>  15
atgttcgtgt ttctggtgct gctgcctctg gtgtccagc                              39


<210>  16
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26S minimal promoter

<400>  16
ctctctacgg ctaacctgaa tgga                                              24


<210>  17
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T7 promoter

<400>  17
taatacgact cactatag                                                     18


<210>  18
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  5'-UTR

<400>  18
ataggcggcg catgagagaa gcccagacca attacctacc caaa                        44


<210>  19
<211>  195
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alpha 5' replication sequence from nsP1

<400>  19
taggagaaag ttcacgttga catcgaggaa gacagcccat tcctcagagc tttgcagcgg       60

agcttcccgc agtttgaggt agaagccaag caggtcactg ataatgacca tgctaatgcc      120

agagcgtttt cgcatctggc ttcaaaactg atcgaaacgg aggtggaccc atccgacacg      180

atccttgaca ttgga                                                       195


<210>  20
<211>  142
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gDLP

<400>  20
atagtcagca tagtacattt catctgacta atactacaac accaccacca tgaatagagg       60

attctttaac atgctcggcc gccgcccctt cccggccccc actgccatgt ggaggccgcg      120

gagaaggagg caggcggccc cg                                               142


<210>  21
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  21
ggaagcggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  22
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  22

Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210>  23
<211>  5796
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DLP nsp ORF encoding a 3' portion of gDLP, P2A and nsp1-3

<400>  23
atgaatagag gattctttaa catgctcggc cgccgcccct tcccggcccc cactgccatg       60

tggaggccgc ggagaaggag gcaggcggcc ccgggaagcg gagctactaa cttcagcctg      120

ctgaagcagg ctggagacgt ggaggagaac cctggacctg agaaagttca cgttgacatc      180

gaggaagaca gcccattcct cagagctttg cagcggagct tcccgcagtt tgaggtagaa      240

gccaagcagg tcactgataa tgaccatgct aatgccagag cgttttcgca tctggcttca      300

aaactgatcg aaacggaggt ggacccatcc gacacgatcc ttgacattgg aagtgcgccc      360

gcccgcagaa tgtattctaa gcacaagtat cattgtatct gtccgatgag atgtgcggaa      420

gatccggaca gattgtataa gtatgcaact aagctgaaga aaaactgtaa ggaaataact      480

gataaggaat tggacaagaa aatgaaggag ctcgccgccg tcatgagcga ccctgacctg      540

gaaactgaga ctatgtgcct ccacgacgac gagtcgtgtc gctacgaagg gcaagtcgct      600

gtttaccagg atgtatacgc ggttgacgga ccgacaagtc tctatcacca agccaataag      660

ggagttagag tcgcctactg gataggcttt gacaccaccc cttttatgtt taagaacttg      720

gctggagcat atccatcata ctctaccaac tgggccgacg aaaccgtgtt aacggctcgt      780

aacataggcc tatgcagctc tgacgttatg gagcggtcac gtagagggat gtccattctt      840

agaaagaagt atttgaaacc atccaacaat gttctattct ctgttggctc gaccatctac      900

cacgagaaga gggacttact gaggagctgg cacctgccgt ctgtatttca cttacgtggc      960

aagcaaaatt acacatgtcg gtgtgagact atagttagtt gcgacgggta cgtcgttaaa     1020

agaatagcta tcagtccagg cctgtatggg aagccttcag gctatgctgc tacgatgcac     1080

cgcgagggat tcttgtgctg caaagtgaca gacacattga acggggagag ggtctctttt     1140

cccgtgtgca cgtatgtgcc agctacattg tgtgaccaaa tgactggcat actggcaaca     1200

gatgtcagtg cggacgacgc gcaaaaactg ctggttgggc tcaaccagcg tatagtcgtc     1260

aacggtcgca cccagagaaa caccaatacc atgaaaaatt accttttgcc cgtagtggcc     1320

caggcatttg ctaggtgggc aaaggaatat aaggaagatc aagaagatga aaggccacta     1380

ggactacgag atagacagtt agtcatgggg tgttgttggg cttttagaag gcacaagata     1440

acatctattt ataagcgccc ggatacccaa accatcatca aagtgaacag cgatttccac     1500

tcattcgtgc tgcccaggat aggcagtaac acattggaga tcgggctgag aacaagaatc     1560

aggaaaatgt tagaggagca caaggagccg tcacctctca ttaccgccga ggacgtacaa     1620

gaagctaagt gcgcagccga tgaggctaag gaggtgcgtg aagccgagga gttgcgcgca     1680

gctctaccac ctttggcagc tgatgttgag gagcccactc tggaagccga tgtcgacttg     1740

atgttacaag aggctggggc cggctcagtg gagacacctc gtggcttgat aaaggttacc     1800

agctacgatg gcgaggacaa gatcggctct tacgctgtgc tttctccgca ggctgtactc     1860

aagagtgaaa aattatcttg catccaccct ctcgctgaac aagtcatagt gataacacac     1920

tctggccgaa aagggcgtta tgccgtggaa ccataccatg gtaaagtagt ggtgccagag     1980

ggacatgcaa tacccgtcca ggactttcaa gctctgagtg aaagtgccac cattgtgtac     2040

aacgaacgtg agttcgtaaa caggtacctg caccatattg ccacacatgg aggagcgctg     2100

aacactgatg aagaatatta caaaactgtc aagcccagcg agcacgacgg cgaatacctg     2160

tacgacatcg acaggaaaca gtgcgtcaag aaagaactag tcactgggct agggctcaca     2220

ggcgagctgg tggatcctcc cttccatgaa ttcgcctacg agagtctgag aacacgacca     2280

gccgctcctt accaagtacc aaccataggg gtgtatggcg tgccaggatc aggcaagtct     2340

ggcatcatta aaagcgcagt caccaaaaaa gatctagtgg tgagcgccaa gaaagaaaac     2400

tgtgcagaaa ttataaggga cgtcaagaaa atgaaagggc tggacgtcaa tgccagaact     2460

gtggactcag tgctcttgaa tggatgcaaa caccccgtag agaccctgta tattgacgaa     2520

gcttttgctt gtcatgcagg tactctcaga gcgctcatag ccattataag acctaaaaag     2580

gcagtgctct gcggggatcc caaacagtgc ggttttttta acatgatgtg cctgaaagtg     2640

cattttaacc acgagatttg cacacaagtc ttccacaaaa gcatctctcg ccgttgcact     2700

aaatctgtga cttcggtcgt ctcaaccttg ttttacgaca aaaaaatgag aacgacgaat     2760

ccgaaagaga ctaagattgt gattgacact accggcagta ccaaacctaa gcaggacgat     2820

ctcattctca cttgtttcag agggtgggtg aagcagttgc aaatagatta caaaggcaac     2880

gaaataatga cggcagctgc ctctcaaggg ctgacccgta aaggtgtgta tgccgttcgg     2940

tacaaggtga atgaaaatcc tctgtacgca cccacctctg aacatgtgaa cgtcctactg     3000

acccgcacgg aggaccgcat cgtgtggaaa acactagccg gcgacccatg gataaaaaca     3060

ctgactgcca agtaccctgg gaatttcact gccacgatag aggagtggca agcagagcat     3120

gatgccatca tgaggcacat cttggagaga ccggacccta ccgacgtctt ccagaataag     3180

gcaaacgtgt gttgggccaa ggctttagtg ccggtgctga agaccgctgg catagacatg     3240

accactgaac aatggaacac tgtggattat tttgaaacgg acaaagctca ctcagcagag     3300

atagtattga accaactatg cgtgaggttc tttggactcg atctggactc cggtctattt     3360

tctgcaccca ctgttccgtt atccattagg aataatcact gggataactc cccgtcgcct     3420

aacatgtacg ggctgaataa agaagtggtc cgtcagctct ctcgcaggta cccacaactg     3480

cctcgggcag ttgccactgg aagagtctat gacatgaaca ctggtacact gcgcaattat     3540

gatccgcgca taaacctagt acctgtaaac agaagactgc ctcatgcttt agtcctccac     3600

cataatgaac acccacagag tgacttttct tcattcgtca gcaaattgaa gggcagaact     3660

gtcctggtgg tcggggaaaa gttgtccgtc ccaggcaaaa tggttgactg gttgtcagac     3720

cggcctgagg ctaccttcag agctcggctg gatttaggca tcccaggtga tgtgcccaaa     3780

tatgacataa tatttgttaa tgtgaggacc ccatataaat accatcacta tcagcagtgt     3840

gaagaccatg ccattaagct tagcatgttg accaagaaag cttgtctgca tctgaatccc     3900

ggcggaacct gtgtcagcat aggttatggt tacgctgaca gggccagcga aagcatcatt     3960

ggtgctatag cgcggcagtt caagttttcc cgggtatgca aaccgaaatc ctcacttgaa     4020

gagacggaag ttctgtttgt attcattggg tacgatcgca aggcccgtac gcacaatcct     4080

tacaagcttt catcaacctt gaccaacatt tatacaggtt ccagactcca cgaagccgga     4140

tgtgcaccct catatcatgt ggtgcgaggg gatattgcca cggccaccga aggagtgatt     4200

ataaatgctg ctaacagcaa aggacaacct ggcggagggg tgtgcggagc gctgtataag     4260

aaattcccgg aaagcttcga tttacagccg atcgaagtag gaaaagcgcg actggtcaaa     4320

ggtgcagcta aacatatcat tcatgccgta ggaccaaact tcaacaaagt ttcggaggtt     4380

gaaggtgaca aacagttggc agaggcttat gagtccatcg ctaagattgt caacgataac     4440

aattacaagt cagtagcgat tccactgttg tccaccggca tcttttccgg gaacaaagat     4500

cgactaaccc aatcattgaa ccatttgctg acagctttag acaccactga tgcagatgta     4560

gccatatact gcagggacaa gaaatgggaa atgactctca aggaagcagt ggctaggaga     4620

gaagcagtgg aggagatatg catatccgac gactcttcag tgacagaacc tgatgcagag     4680

ctggtgaggg tgcatccgaa gagttctttg gctggaagga agggctacag cacaagcgat     4740

ggcaaaactt tctcatattt ggaagggacc aagtttcacc aggcggccaa ggatatagca     4800

gaaattaatg ccatgtggcc cgttgcaacg gaggccaatg agcaggtatg catgtatatc     4860

ctcggagaaa gcatgagcag tattaggtcg aaatgccccg tcgaagagtc ggaagcctcc     4920

acaccaccta gcacgctgcc ttgcttgtgc atccatgcca tgactccaga aagagtacag     4980

cgcctaaaag cctcacgtcc agaacaaatt actgtgtgct catcctttcc attgccgaag     5040

tatagaatca ctggtgtgca gaagatccaa tgctcccagc ctatattgtt ctcaccgaaa     5100

gtgcctgcgt atattcatcc aaggaagtat ctcgtggaaa caccaccggt agacgagact     5160

ccggagccat cggcagagaa ccaatccaca gaggggacac ctgaacaacc accacttata     5220

accgaggatg agaccaggac tagaacgcct gagccgatca tcatcgaaga ggaagaagag     5280

gatagcataa gtttgctgtc agatggcccg acccaccagg tgctgcaagt cgaggcagac     5340

attcacgggc cgccctctgt atctagctca tcctggtcca ttcctcatgc atccgacttt     5400

gatgtggaca gtttatccat acttgacacc ctggagggag ctagcgtgac cagcggggca     5460

acgtcagccg agactaactc ttacttcgca aagagtatgg agtttctggc gcgaccggtg     5520

cctgcgcctc gaacagtatt caggaaccct ccacatcccg ctccgcgcac aagaacaccg     5580

tcacttgcac ccagcagggc ctgctcgaga accagcctag tttccacccc gccaggcgtg     5640

aatagggtga tcactagaga ggagctcgag gcgcttaccc cgtcacgcac tcctagcagg     5700

tcggtctcga gaaccagcct ggtctccaac ccgccaggcg taaatagggt gattacaaga     5760

gaggagtttg aggcgttcgt agcacaacaa caatga                               5796


<210>  24
<211>  1602
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nsp1

<400>  24
gagaaagttc acgttgacat cgaggaagac agcccattcc tcagagcttt gcagcggagc       60

ttcccgcagt ttgaggtaga agccaagcag gtcactgata atgaccatgc taatgccaga      120

gcgttttcgc atctggcttc aaaactgatc gaaacggagg tggacccatc cgacacgatc      180

cttgacattg gaagtgcgcc cgcccgcaga atgtattcta agcacaagta tcattgtatc      240

tgtccgatga gatgtgcgga agatccggac agattgtata agtatgcaac taagctgaag      300

aaaaactgta aggaaataac tgataaggaa ttggacaaga aaatgaagga gctcgccgcc      360

gtcatgagcg accctgacct ggaaactgag actatgtgcc tccacgacga cgagtcgtgt      420

cgctacgaag ggcaagtcgc tgtttaccag gatgtatacg cggttgacgg accgacaagt      480

ctctatcacc aagccaataa gggagttaga gtcgcctact ggataggctt tgacaccacc      540

ccttttatgt ttaagaactt ggctggagca tatccatcat actctaccaa ctgggccgac      600

gaaaccgtgt taacggctcg taacataggc ctatgcagct ctgacgttat ggagcggtca      660

cgtagaggga tgtccattct tagaaagaag tatttgaaac catccaacaa tgttctattc      720

tctgttggct cgaccatcta ccacgagaag agggacttac tgaggagctg gcacctgccg      780

tctgtatttc acttacgtgg caagcaaaat tacacatgtc ggtgtgagac tatagttagt      840

tgcgacgggt acgtcgttaa aagaatagct atcagtccag gcctgtatgg gaagccttca      900

ggctatgctg ctacgatgca ccgcgaggga ttcttgtgct gcaaagtgac agacacattg      960

aacggggaga gggtctcttt tcccgtgtgc acgtatgtgc cagctacatt gtgtgaccaa     1020

atgactggca tactggcaac agatgtcagt gcggacgacg cgcaaaaact gctggttggg     1080

ctcaaccagc gtatagtcgt caacggtcgc acccagagaa acaccaatac catgaaaaat     1140

taccttttgc ccgtagtggc ccaggcattt gctaggtggg caaaggaata taaggaagat     1200

caagaagatg aaaggccact aggactacga gatagacagt tagtcatggg gtgttgttgg     1260

gcttttagaa ggcacaagat aacatctatt tataagcgcc cggataccca aaccatcatc     1320

aaagtgaaca gcgatttcca ctcattcgtg ctgcccagga taggcagtaa cacattggag     1380

atcgggctga gaacaagaat caggaaaatg ttagaggagc acaaggagcc gtcacctctc     1440

attaccgccg aggacgtaca agaagctaag tgcgcagccg atgaggctaa ggaggtgcgt     1500

gaagccgagg agttgcgcgc agctctacca cctttggcag ctgatgttga ggagcccact     1560

ctggaagccg atgtcgactt gatgttacaa gaggctgggg cc                        1602


<210>  25
<211>  2382
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nsp2

<400>  25
ggctcagtgg agacacctcg tggcttgata aaggttacca gctacgatgg cgaggacaag       60

atcggctctt acgctgtgct ttctccgcag gctgtactca agagtgaaaa attatcttgc      120

atccaccctc tcgctgaaca agtcatagtg ataacacact ctggccgaaa agggcgttat      180

gccgtggaac cataccatgg taaagtagtg gtgccagagg gacatgcaat acccgtccag      240

gactttcaag ctctgagtga aagtgccacc attgtgtaca acgaacgtga gttcgtaaac      300

aggtacctgc accatattgc cacacatgga ggagcgctga acactgatga agaatattac      360

aaaactgtca agcccagcga gcacgacggc gaatacctgt acgacatcga caggaaacag      420

tgcgtcaaga aagaactagt cactgggcta gggctcacag gcgagctggt ggatcctccc      480

ttccatgaat tcgcctacga gagtctgaga acacgaccag ccgctcctta ccaagtacca      540

accatagggg tgtatggcgt gccaggatca ggcaagtctg gcatcattaa aagcgcagtc      600

accaaaaaag atctagtggt gagcgccaag aaagaaaact gtgcagaaat tataagggac      660

gtcaagaaaa tgaaagggct ggacgtcaat gccagaactg tggactcagt gctcttgaat      720

ggatgcaaac accccgtaga gaccctgtat attgacgaag cttttgcttg tcatgcaggt      780

actctcagag cgctcatagc cattataaga cctaaaaagg cagtgctctg cggggatccc      840

aaacagtgcg gtttttttaa catgatgtgc ctgaaagtgc attttaacca cgagatttgc      900

acacaagtct tccacaaaag catctctcgc cgttgcacta aatctgtgac ttcggtcgtc      960

tcaaccttgt tttacgacaa aaaaatgaga acgacgaatc cgaaagagac taagattgtg     1020

attgacacta ccggcagtac caaacctaag caggacgatc tcattctcac ttgtttcaga     1080

gggtgggtga agcagttgca aatagattac aaaggcaacg aaataatgac ggcagctgcc     1140

tctcaagggc tgacccgtaa aggtgtgtat gccgttcggt acaaggtgaa tgaaaatcct     1200

ctgtacgcac ccacctctga acatgtgaac gtcctactga cccgcacgga ggaccgcatc     1260

gtgtggaaaa cactagccgg cgacccatgg ataaaaacac tgactgccaa gtaccctggg     1320

aatttcactg ccacgataga ggagtggcaa gcagagcatg atgccatcat gaggcacatc     1380

ttggagagac cggaccctac cgacgtcttc cagaataagg caaacgtgtg ttgggccaag     1440

gctttagtgc cggtgctgaa gaccgctggc atagacatga ccactgaaca atggaacact     1500

gtggattatt ttgaaacgga caaagctcac tcagcagaga tagtattgaa ccaactatgc     1560

gtgaggttct ttggactcga tctggactcc ggtctatttt ctgcacccac tgttccgtta     1620

tccattagga ataatcactg ggataactcc ccgtcgccta acatgtacgg gctgaataaa     1680

gaagtggtcc gtcagctctc tcgcaggtac ccacaactgc ctcgggcagt tgccactgga     1740

agagtctatg acatgaacac tggtacactg cgcaattatg atccgcgcat aaacctagta     1800

cctgtaaaca gaagactgcc tcatgcttta gtcctccacc ataatgaaca cccacagagt     1860

gacttttctt cattcgtcag caaattgaag ggcagaactg tcctggtggt cggggaaaag     1920

ttgtccgtcc caggcaaaat ggttgactgg ttgtcagacc ggcctgaggc taccttcaga     1980

gctcggctgg atttaggcat cccaggtgat gtgcccaaat atgacataat atttgttaat     2040

gtgaggaccc catataaata ccatcactat cagcagtgtg aagaccatgc cattaagctt     2100

agcatgttga ccaagaaagc ttgtctgcat ctgaatcccg gcggaacctg tgtcagcata     2160

ggttatggtt acgctgacag ggccagcgaa agcatcattg gtgctatagc gcggcagttc     2220

aagttttccc gggtatgcaa accgaaatcc tcacttgaag agacggaagt tctgtttgta     2280

ttcattgggt acgatcgcaa ggcccgtacg cacaatcctt acaagctttc atcaaccttg     2340

accaacattt atacaggttc cagactccac gaagccggat gt                        2382


<210>  26
<211>  1671
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nsp3

<400>  26
gcaccctcat atcatgtggt gcgaggggat attgccacgg ccaccgaagg agtgattata       60

aatgctgcta acagcaaagg acaacctggc ggaggggtgt gcggagcgct gtataagaaa      120

ttcccggaaa gcttcgattt acagccgatc gaagtaggaa aagcgcgact ggtcaaaggt      180

gcagctaaac atatcattca tgccgtagga ccaaacttca acaaagtttc ggaggttgaa      240

ggtgacaaac agttggcaga ggcttatgag tccatcgcta agattgtcaa cgataacaat      300

tacaagtcag tagcgattcc actgttgtcc accggcatct tttccgggaa caaagatcga      360

ctaacccaat cattgaacca tttgctgaca gctttagaca ccactgatgc agatgtagcc      420

atatactgca gggacaagaa atgggaaatg actctcaagg aagcagtggc taggagagaa      480

gcagtggagg agatatgcat atccgacgac tcttcagtga cagaacctga tgcagagctg      540

gtgagggtgc atccgaagag ttctttggct ggaaggaagg gctacagcac aagcgatggc      600

aaaactttct catatttgga agggaccaag tttcaccagg cggccaagga tatagcagaa      660

attaatgcca tgtggcccgt tgcaacggag gccaatgagc aggtatgcat gtatatcctc      720

ggagaaagca tgagcagtat taggtcgaaa tgccccgtcg aagagtcgga agcctccaca      780

ccacctagca cgctgccttg cttgtgcatc catgccatga ctccagaaag agtacagcgc      840

ctaaaagcct cacgtccaga acaaattact gtgtgctcat cctttccatt gccgaagtat      900

agaatcactg gtgtgcagaa gatccaatgc tcccagccta tattgttctc accgaaagtg      960

cctgcgtata ttcatccaag gaagtatctc gtggaaacac caccggtaga cgagactccg     1020

gagccatcgg cagagaacca atccacagag gggacacctg aacaaccacc acttataacc     1080

gaggatgaga ccaggactag aacgcctgag ccgatcatca tcgaagagga agaagaggat     1140

agcataagtt tgctgtcaga tggcccgacc caccaggtgc tgcaagtcga ggcagacatt     1200

cacgggccgc cctctgtatc tagctcatcc tggtccattc ctcatgcatc cgactttgat     1260

gtggacagtt tatccatact tgacaccctg gagggagcta gcgtgaccag cggggcaacg     1320

tcagccgaga ctaactctta cttcgcaaag agtatggagt ttctggcgcg accggtgcct     1380

gcgcctcgaa cagtattcag gaaccctcca catcccgctc cgcgcacaag aacaccgtca     1440

cttgcaccca gcagggcctg ctcgagaacc agcctagttt ccaccccgcc aggcgtgaat     1500

agggtgatca ctagagagga gctcgaggcg cttaccccgt cacgcactcc tagcaggtcg     1560

gtctcgagaa ccagcctggt ctccaacccg ccaggcgtaa atagggtgat tacaagagag     1620

gagtttgagg cgttcgtagc acaacaacaa tgacggtttg atgcgggtgc a              1671


<210>  27
<211>  1821
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nsp4

<400>  27
tacatctttt cctccgacac cggtcaaggg catttacaac aaaaatcagt aaggcaaacg       60

gtgctatccg aagtggtgtt ggagaggacc gaattggaga tttcgtatgc cccgcgcctc      120

gaccaagaaa aagaagaatt actacgcaag aaattacagt taaatcccac acctgctaac      180

agaagcagat accagtccag gaaggtggag aacatgaaag ccataacagc tagacgtatt      240

ctgcaaggcc tagggcatta tttgaaggca gaaggaaaag tggagtgcta ccgaaccctg      300

catcctgttc ctttgtattc atctagtgtg aaccgtgcct tttcaagccc caaggtcgca      360

gtggaagcct gtaacgccat gttgaaagag aactttccga ctgtggcttc ttactgtatt      420

attccagagt acgatgccta tttggacatg gttgacggag cttcatgctg cttagacact      480

gccagttttt gccctgcaaa gctgcgcagc tttccaaaga aacactccta tttggaaccc      540

acaatacgat cggcagtgcc ttcagcgatc cagaacacgc tccagaacgt cctggcagct      600

gccacaaaaa gaaattgcaa tgtcacgcaa atgagagaat tgcccgtatt ggattcggcg      660

gcctttaatg tggaatgctt caagaaatat gcgtgtaata atgaatattg ggaaacgttt      720

aaagaaaacc ccatcaggct tactgaagaa aacgtggtaa attacattac caaattaaaa      780

ggaccaaaag ctgctgctct ttttgcgaag acacataatt tgaatatgtt gcaggacata      840

ccaatggaca ggtttgtaat ggacttaaag agagacgtga aagtgactcc aggaacaaaa      900

catactgaag aacggcccaa ggtacaggtg atccaggctg ccgatccgct agcaacagcg      960

tatctgtgcg gaatccaccg agagctggtt aggagattaa atgcggtcct gcttccgaac     1020

attcatacac tgtttgatat gtcggctgaa gactttgacg ctattatagc cgagcacttc     1080

cagcctgggg attgtgttct ggaaactgac atcgcgtcgt ttgataaaag tgaggacgac     1140

gccatggctc tgaccgcgtt aatgattctg gaagacttag gtgtggacgc agagctgttg     1200

acgctgattg aggcggcttt cggcgaaatt tcatcaatac atttgcccac taaaactaaa     1260

tttaaattcg gagccatgat gaaatctgga atgttcctca cactgtttgt gaacacagtc     1320

attaacattg taatcgcaag cagagtgttg agagaacggc taaccggatc accatgtgca     1380

gcattcattg gagatgacaa tatcgtgaaa ggagtcaaat cggacaaatt aatggcagac     1440

aggtgcgcca cctggttgaa tatggaagtc aagattatag atgctgtggt gggcgagaaa     1500

gcgccttatt tctgtggagg gtttattttg tgtgactccg tgaccggcac agcgtgccgt     1560

gtggcagacc ccctaaaaag gctgtttaag cttggcaaac ctctggcagc agacgatgaa     1620

catgatgatg acaggagaag ggcattgcat gaagagtcaa cacgctggaa ccgagtgggt     1680

attctttcag agctgtgcaa ggcagtagaa tcaaggtatg aaaccgtagg aacttccatc     1740

atagttatgg ccatgactac tctagctagc agtgttaaat cattcagcta cctgagaggg     1800

gcccctataa ctctctacgg c                                               1821


<210>  28
<211>  117
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3'-UTR

<400>  28
atacagcagc aattggcaag ctgcttacat agaactcgcg gcgattggca tgccgcttta       60

aaatttttat tttatttttc ttttcttttc cgaatcggat tttgttttta atatttc         117


<210>  29
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  poly A site

<400>  29
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa                             40


<210>  30
<211>  11987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SMARRT CoV2 Vaccine 1158

<400>  30
gataggcggc gcatgagaga agcccagacc aattacctac ccaaatagga gaaagttcac       60

gttgacatcg aggaagacag cccattcctc agagctttgc agcggagctt cccgcagttt      120

gaggtagaag ccaagcaggt cactgataat gaccatgcta atgccagagc gttttcgcat      180

ctggcttcaa aactgatcga aacggaggtg gacccatccg acacgatcct tgacattgga      240

atagtcagca tagtacattt catctgacta atactacaac accaccacca tgaatagagg      300

attctttaac atgctcggcc gccgcccctt cccggccccc actgccatgt ggaggccgcg      360

gagaaggagg caggcggccc cgggaagcgg agctactaac ttcagcctgc tgaagcaggc      420

tggagacgtg gaggagaacc ctggacctga gaaagttcac gttgacatcg aggaagacag      480

cccattcctc agagctttgc agcggagctt cccgcagttt gaggtagaag ccaagcaggt      540

cactgataat gaccatgcta atgccagagc gttttcgcat ctggcttcaa aactgatcga      600

aacggaggtg gacccatccg acacgatcct tgacattgga agtgcgcccg cccgcagaat      660

gtattctaag cacaagtatc attgtatctg tccgatgaga tgtgcggaag atccggacag      720

attgtataag tatgcaacta agctgaagaa aaactgtaag gaaataactg ataaggaatt      780

ggacaagaaa atgaaggagc tcgccgccgt catgagcgac cctgacctgg aaactgagac      840

tatgtgcctc cacgacgacg agtcgtgtcg ctacgaaggg caagtcgctg tttaccagga      900

tgtatacgcg gttgacggac cgacaagtct ctatcaccaa gccaataagg gagttagagt      960

cgcctactgg ataggctttg acaccacccc ttttatgttt aagaacttgg ctggagcata     1020

tccatcatac tctaccaact gggccgacga aaccgtgtta acggctcgta acataggcct     1080

atgcagctct gacgttatgg agcggtcacg tagagggatg tccattctta gaaagaagta     1140

tttgaaacca tccaacaatg ttctattctc tgttggctcg accatctacc acgagaagag     1200

ggacttactg aggagctggc acctgccgtc tgtatttcac ttacgtggca agcaaaatta     1260

cacatgtcgg tgtgagacta tagttagttg cgacgggtac gtcgttaaaa gaatagctat     1320

cagtccaggc ctgtatggga agccttcagg ctatgctgct acgatgcacc gcgagggatt     1380

cttgtgctgc aaagtgacag acacattgaa cggggagagg gtctcttttc ccgtgtgcac     1440

gtatgtgcca gctacattgt gtgaccaaat gactggcata ctggcaacag atgtcagtgc     1500

ggacgacgcg caaaaactgc tggttgggct caaccagcgt atagtcgtca acggtcgcac     1560

ccagagaaac accaatacca tgaaaaatta ccttttgccc gtagtggccc aggcatttgc     1620

taggtgggca aaggaatata aggaagatca agaagatgaa aggccactag gactacgaga     1680

tagacagtta gtcatggggt gttgttgggc ttttagaagg cacaagataa catctattta     1740

taagcgcccg gatacccaaa ccatcatcaa agtgaacagc gatttccact cattcgtgct     1800

gcccaggata ggcagtaaca cattggagat cgggctgaga acaagaatca ggaaaatgtt     1860

agaggagcac aaggagccgt cacctctcat taccgccgag gacgtacaag aagctaagtg     1920

cgcagccgat gaggctaagg aggtgcgtga agccgaggag ttgcgcgcag ctctaccacc     1980

tttggcagct gatgttgagg agcccactct ggaagccgat gtcgacttga tgttacaaga     2040

ggctggggcc ggctcagtgg agacacctcg tggcttgata aaggttacca gctacgatgg     2100

cgaggacaag atcggctctt acgctgtgct ttctccgcag gctgtactca agagtgaaaa     2160

attatcttgc atccaccctc tcgctgaaca agtcatagtg ataacacact ctggccgaaa     2220

agggcgttat gccgtggaac cataccatgg taaagtagtg gtgccagagg gacatgcaat     2280

acccgtccag gactttcaag ctctgagtga aagtgccacc attgtgtaca acgaacgtga     2340

gttcgtaaac aggtacctgc accatattgc cacacatgga ggagcgctga acactgatga     2400

agaatattac aaaactgtca agcccagcga gcacgacggc gaatacctgt acgacatcga     2460

caggaaacag tgcgtcaaga aagaactagt cactgggcta gggctcacag gcgagctggt     2520

ggatcctccc ttccatgaat tcgcctacga gagtctgaga acacgaccag ccgctcctta     2580

ccaagtacca accatagggg tgtatggcgt gccaggatca ggcaagtctg gcatcattaa     2640

aagcgcagtc accaaaaaag atctagtggt gagcgccaag aaagaaaact gtgcagaaat     2700

tataagggac gtcaagaaaa tgaaagggct ggacgtcaat gccagaactg tggactcagt     2760

gctcttgaat ggatgcaaac accccgtaga gaccctgtat attgacgaag cttttgcttg     2820

tcatgcaggt actctcagag cgctcatagc cattataaga cctaaaaagg cagtgctctg     2880

cggggatccc aaacagtgcg gtttttttaa catgatgtgc ctgaaagtgc attttaacca     2940

cgagatttgc acacaagtct tccacaaaag catctctcgc cgttgcacta aatctgtgac     3000

ttcggtcgtc tcaaccttgt tttacgacaa aaaaatgaga acgacgaatc cgaaagagac     3060

taagattgtg attgacacta ccggcagtac caaacctaag caggacgatc tcattctcac     3120

ttgtttcaga gggtgggtga agcagttgca aatagattac aaaggcaacg aaataatgac     3180

ggcagctgcc tctcaagggc tgacccgtaa aggtgtgtat gccgttcggt acaaggtgaa     3240

tgaaaatcct ctgtacgcac ccacctctga acatgtgaac gtcctactga cccgcacgga     3300

ggaccgcatc gtgtggaaaa cactagccgg cgacccatgg ataaaaacac tgactgccaa     3360

gtaccctggg aatttcactg ccacgataga ggagtggcaa gcagagcatg atgccatcat     3420

gaggcacatc ttggagagac cggaccctac cgacgtcttc cagaataagg caaacgtgtg     3480

ttgggccaag gctttagtgc cggtgctgaa gaccgctggc atagacatga ccactgaaca     3540

atggaacact gtggattatt ttgaaacgga caaagctcac tcagcagaga tagtattgaa     3600

ccaactatgc gtgaggttct ttggactcga tctggactcc ggtctatttt ctgcacccac     3660

tgttccgtta tccattagga ataatcactg ggataactcc ccgtcgccta acatgtacgg     3720

gctgaataaa gaagtggtcc gtcagctctc tcgcaggtac ccacaactgc ctcgggcagt     3780

tgccactgga agagtctatg acatgaacac tggtacactg cgcaattatg atccgcgcat     3840

aaacctagta cctgtaaaca gaagactgcc tcatgcttta gtcctccacc ataatgaaca     3900

cccacagagt gacttttctt cattcgtcag caaattgaag ggcagaactg tcctggtggt     3960

cggggaaaag ttgtccgtcc caggcaaaat ggttgactgg ttgtcagacc ggcctgaggc     4020

taccttcaga gctcggctgg atttaggcat cccaggtgat gtgcccaaat atgacataat     4080

atttgttaat gtgaggaccc catataaata ccatcactat cagcagtgtg aagaccatgc     4140

cattaagctt agcatgttga ccaagaaagc ttgtctgcat ctgaatcccg gcggaacctg     4200

tgtcagcata ggttatggtt acgctgacag ggccagcgaa agcatcattg gtgctatagc     4260

gcggcagttc aagttttccc gggtatgcaa accgaaatcc tcacttgaag agacggaagt     4320

tctgtttgta ttcattgggt acgatcgcaa ggcccgtacg cacaatcctt acaagctttc     4380

atcaaccttg accaacattt atacaggttc cagactccac gaagccggat gtgcaccctc     4440

atatcatgtg gtgcgagggg atattgccac ggccaccgaa ggagtgatta taaatgctgc     4500

taacagcaaa ggacaacctg gcggaggggt gtgcggagcg ctgtataaga aattcccgga     4560

aagcttcgat ttacagccga tcgaagtagg aaaagcgcga ctggtcaaag gtgcagctaa     4620

acatatcatt catgccgtag gaccaaactt caacaaagtt tcggaggttg aaggtgacaa     4680

acagttggca gaggcttatg agtccatcgc taagattgtc aacgataaca attacaagtc     4740

agtagcgatt ccactgttgt ccaccggcat cttttccggg aacaaagatc gactaaccca     4800

atcattgaac catttgctga cagctttaga caccactgat gcagatgtag ccatatactg     4860

cagggacaag aaatgggaaa tgactctcaa ggaagcagtg gctaggagag aagcagtgga     4920

ggagatatgc atatccgacg actcttcagt gacagaacct gatgcagagc tggtgagggt     4980

gcatccgaag agttctttgg ctggaaggaa gggctacagc acaagcgatg gcaaaacttt     5040

ctcatatttg gaagggacca agtttcacca ggcggccaag gatatagcag aaattaatgc     5100

catgtggccc gttgcaacgg aggccaatga gcaggtatgc atgtatatcc tcggagaaag     5160

catgagcagt attaggtcga aatgccccgt cgaagagtcg gaagcctcca caccacctag     5220

cacgctgcct tgcttgtgca tccatgccat gactccagaa agagtacagc gcctaaaagc     5280

ctcacgtcca gaacaaatta ctgtgtgctc atcctttcca ttgccgaagt atagaatcac     5340

tggtgtgcag aagatccaat gctcccagcc tatattgttc tcaccgaaag tgcctgcgta     5400

tattcatcca aggaagtatc tcgtggaaac accaccggta gacgagactc cggagccatc     5460

ggcagagaac caatccacag aggggacacc tgaacaacca ccacttataa ccgaggatga     5520

gaccaggact agaacgcctg agccgatcat catcgaagag gaagaagagg atagcataag     5580

tttgctgtca gatggcccga cccaccaggt gctgcaagtc gaggcagaca ttcacgggcc     5640

gccctctgta tctagctcat cctggtccat tcctcatgca tccgactttg atgtggacag     5700

tttatccata cttgacaccc tggagggagc tagcgtgacc agcggggcaa cgtcagccga     5760

gactaactct tacttcgcaa agagtatgga gtttctggcg cgaccggtgc ctgcgcctcg     5820

aacagtattc aggaaccctc cacatcccgc tccgcgcaca agaacaccgt cacttgcacc     5880

cagcagggcc tgctcgagaa ccagcctagt ttccaccccg ccaggcgtga atagggtgat     5940

cactagagag gagctcgagg cgcttacccc gtcacgcact cctagcaggt cggtctcgag     6000

aaccagcctg gtctccaacc cgccaggcgt aaatagggtg attacaagag aggagtttga     6060

ggcgttcgta gcacaacaac aatgacggtt tgatgcgggt gcatacatct tttcctccga     6120

caccggtcaa gggcatttac aacaaaaatc agtaaggcaa acggtgctat ccgaagtggt     6180

gttggagagg accgaattgg agatttcgta tgccccgcgc ctcgaccaag aaaaagaaga     6240

attactacgc aagaaattac agttaaatcc cacacctgct aacagaagca gataccagtc     6300

caggaaggtg gagaacatga aagccataac agctagacgt attctgcaag gcctagggca     6360

ttatttgaag gcagaaggaa aagtggagtg ctaccgaacc ctgcatcctg ttcctttgta     6420

ttcatctagt gtgaaccgtg ccttttcaag ccccaaggtc gcagtggaag cctgtaacgc     6480

catgttgaaa gagaactttc cgactgtggc ttcttactgt attattccag agtacgatgc     6540

ctatttggac atggttgacg gagcttcatg ctgcttagac actgccagtt tttgccctgc     6600

aaagctgcgc agctttccaa agaaacactc ctatttggaa cccacaatac gatcggcagt     6660

gccttcagcg atccagaaca cgctccagaa cgtcctggca gctgccacaa aaagaaattg     6720

caatgtcacg caaatgagag aattgcccgt attggattcg gcggccttta atgtggaatg     6780

cttcaagaaa tatgcgtgta ataatgaata ttgggaaacg tttaaagaaa accccatcag     6840

gcttactgaa gaaaacgtgg taaattacat taccaaatta aaaggaccaa aagctgctgc     6900

tctttttgcg aagacacata atttgaatat gttgcaggac ataccaatgg acaggtttgt     6960

aatggactta aagagagacg tgaaagtgac tccaggaaca aaacatactg aagaacggcc     7020

caaggtacag gtgatccagg ctgccgatcc gctagcaaca gcgtatctgt gcggaatcca     7080

ccgagagctg gttaggagat taaatgcggt cctgcttccg aacattcata cactgtttga     7140

tatgtcggct gaagactttg acgctattat agccgagcac ttccagcctg gggattgtgt     7200

tctggaaact gacatcgcgt cgtttgataa aagtgaggac gacgccatgg ctctgaccgc     7260

gttaatgatt ctggaagact taggtgtgga cgcagagctg ttgacgctga ttgaggcggc     7320

tttcggcgaa atttcatcaa tacatttgcc cactaaaact aaatttaaat tcggagccat     7380

gatgaaatct ggaatgttcc tcacactgtt tgtgaacaca gtcattaaca ttgtaatcgc     7440

aagcagagtg ttgagagaac ggctaaccgg atcaccatgt gcagcattca ttggagatga     7500

caatatcgtg aaaggagtca aatcggacaa attaatggca gacaggtgcg ccacctggtt     7560

gaatatggaa gtcaagatta tagatgctgt ggtgggcgag aaagcgcctt atttctgtgg     7620

agggtttatt ttgtgtgact ccgtgaccgg cacagcgtgc cgtgtggcag accccctaaa     7680

aaggctgttt aagcttggca aacctctggc agcagacgat gaacatgatg atgacaggag     7740

aagggcattg catgaagagt caacacgctg gaaccgagtg ggtattcttt cagagctgtg     7800

caaggcagta gaatcaaggt atgaaaccgt aggaacttcc atcatagtta tggccatgac     7860

tactctagct agcagtgtta aatcattcag ctacctgaga ggggccccta taactctcta     7920

cggctaacct gaatggacta cgacatagtc tagtccgcca agatatcatg ttcgtgtttc     7980

tggtgctgct gcctctggtg tccagccaat gcgtgaacct gaccacaaga acccagctgc     8040

ctccagccta caccaacagc tttaccagag gcgtgtacta ccccgacaag gtgttcagat     8100

ccagcgtgct gcactctacc caggacctgt tcctgccttt cttcagcaac gtgacctggt     8160

tccacgccat ccacgtgtcc ggcaccaatg gcaccaagag attcgacaac cccgtgctgc     8220

ccttcaacga cggggtgtac tttgccagca ccgagaagtc caacatcatc agaggctgga     8280

tcttcggcac cacactggac agcaagaccc agagcctgct gatcgtgaac aacgccacca     8340

acgtggtcat caaagtgtgc gagttccagt tctgcaacga ccccttcctg ggcgtctact     8400

atcacaagaa caacaagagc tggatggaaa gcgagttccg ggtgtacagc agcgccaaca     8460

actgcacctt tgaatacgtg tcccagcctt tcctgatgga cctggaaggc aagcagggca     8520

acttcaagaa cctgcgcgag ttcgtgttca agaacatcga cggctacttc aagatctaca     8580

gcaagcacac ccctatcaac ctcgtgcggg atctgcctca gggcttctct gctctggaac     8640

ccctggtgga tctgcccatc ggcatcaaca tcacccggtt tcagacactg ctggccctgc     8700

acagaagcta cctgacacct ggcgatagca gcagcggatg gacagctggt gccgccgctt     8760

actatgtggg ctacctgcag cctagaacct ttctgctgaa gtacaacgag aacggcacca     8820

tcaccgacgc cgtggattgt gctctggatc ctctgagcga gacaaagtgc accctgaagt     8880

ccttcaccgt ggaaaagggc atctaccaga ccagcaactt ccgggtgcag cccaccgaat     8940

ccatcgtgcg gttccccaat atcaccaatc tgtgcccctt cggcgaggtg ttcaatgcca     9000

ccagattcgc ctctgtgtac gcctggaacc ggaagcggat cagcaattgc gtggccgact     9060

actccgtgct gtacaactcc gccagcttca gcaccttcaa gtgctacggc gtgtccccta     9120

ccaagctgaa cgacctgtgc ttcacaaacg tgtacgccga cagcttcgtg atccggggag     9180

atgaagtgcg gcagattgcc cctggacaga ctggcaagat cgccgactac aactacaagc     9240

tgcccgacga cttcaccggc tgtgtgattg cctggaacag caacaacctg gactccaaag     9300

tcggcggcaa ctacaattac ctgtaccggc tgttccggaa gtccaatctg aagcccttcg     9360

agcgggacat ctccaccgag atctatcagg ccggcagcac cccttgtaac ggcgtggaag     9420

gcttcaactg ctacttccca ctgcagtcct acggctttca gcccacaaat ggcgtgggct     9480

atcagcccta cagagtggtg gtgctgagct tcgaactgct gcatgcccct gccacagtgt     9540

gcggccctaa gaaaagcacc aatctcgtga agaacaaatg cgtgaacttc aacttcaacg     9600

gcctgaccgg caccggcgtg ctgacagaga gcaacaagaa gttcctgcca ttccagcagt     9660

ttggccggga tatcgccgat accacagacg ccgttagaga tccccagaca ctggaaatcc     9720

tggacatcac cccttgcagc ttcggcggag tgtctgtgat cacccctggc accaacacca     9780

gcaatcaggt ggcagtgctg taccaggacg tgaactgtac cgaagtgccc gtggccattc     9840

acgccgatca gctgacacct acatggcggg tgtactccac cggcagcaat gtgtttcaga     9900

ccagagccgg ctgtctgatc ggagccgagc acgtgaacaa tagctacgag tgcgacatcc     9960

ccatcggcgc tggcatctgt gccagctacc agacacagac aaacagcccc agacgggcca    10020

gatctgtggc cagccagagc atcattgcct acacaatgtc tctgggcgcc gagaacagcg    10080

tggcctactc caacaactct atcgctatcc ccaccaactt caccatcagc gtgaccacag    10140

agatcctgcc tgtgtccatg accaagacca gcgtggactg caccatgtac atctgcggcg    10200

attccaccga gtgctccaac ctgctgctgc agtacggcag cttctgcacc cagctgaata    10260

gagccctgac agggatcgcc gtggaacagg acaagaacac ccaagaggtg ttcgcccaag    10320

tgaagcagat ctacaagacc cctcctatca aggacttcgg cggcttcaat ttcagccaga    10380

ttctgcccga tcctagcaag cccagcaagc ggagcttcat cgaggacctg ctgttcaaca    10440

aagtgacact ggccgacgcc ggcttcatca agcagtatgg cgattgtctg ggcgacattg    10500

ccgccaggga tctgatttgc gcccagaagt ttaacggact gacagtgctg cctcctctgc    10560

tgaccgatga gatgatcgcc cagtacacat ctgccctgct ggccggcaca atcacaagcg    10620

gctggacatt tggagctggc gccgctctgc agatcccctt tgctatgcag atggcctacc    10680

ggttcaacgg catcggagtg acccagaatg tgctgtacga gaaccagaag ctgatcgcca    10740

accagttcaa cagcgccatc ggcaagatcc aggacagcct gagcagcaca gcaagcgccc    10800

tgggaaagct gcaggacgtg gtcaaccaga atgcccaggc actgaacacc ctggtcaagc    10860

agctgtcctc caacttcggc gccatcagct ctgtgctgaa cgatatcctg agcagactgg    10920

acaaggtgga agccgaggtg cagatcgaca gactgatcac cggaaggctg cagtccctgc    10980

agacctacgt tacccagcag ctgatcagag ccgccgagat tagagcctct gccaatctgg    11040

ccgccaccaa gatgtctgag tgtgtgctgg gccagagcaa gagagtggac ttttgcggca    11100

agggctacca cctgatgagc ttccctcagt ctgcccctca cggcgtggtg tttctgcacg    11160

tgacttatgt gcccgctcaa gagaagaatt tcaccaccgc tccagccatc tgccacgacg    11220

gcaaagccca ctttcctaga gaaggcgtgt tcgtgtccaa cggcacccat tggttcgtga    11280

cacagcggaa cttctacgag ccccagatca tcaccaccga caacaccttc gtgtctggca    11340

actgcgacgt cgtgatcggc attgtgaaca ataccgtgta cgaccctctg cagcccgagc    11400

tggacagctt caaagaggaa ctggacaagt actttaagaa ccacacaagc cccgacgtgg    11460

acctgggcga tatcagcgga atcaatgcca gcgtcgtgaa catccagaaa gagatcgacc    11520

ggctgaacga ggtggccaag aatctgaacg agagcctgat cgacctgcaa gaactgggaa    11580

aatacgagca gtacatcaag tggccttggt acatctggct gggctttatc gccggactga    11640

ttgccatcgt gatggtcaca atcatgctgt gttgcatgac cagctgctgt agctgcctga    11700

agggctgttg tagctgtggc agctgctgca agttcgacga ggacgattct gagcccgtgc    11760

tgaagggcgt gaaactgcac tacacatgat aaggcgcgcc gtttaaacgg ccggccttaa    11820

ttaagtaacg atacagcagc aattggcaag ctgcttacat agaactcgcg gcgattggca    11880

tgccgcttta aaatttttat tttatttttc ttttcttttc cgaatcggat tttgttttta    11940

atatttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                  11987


<210>  31
<211>  11987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  SMARRT CoV2 Vaccine 1159

<400>  31
gataggcggc gcatgagaga agcccagacc aattacctac ccaaatagga gaaagttcac       60

gttgacatcg aggaagacag cccattcctc agagctttgc agcggagctt cccgcagttt      120

gaggtagaag ccaagcaggt cactgataat gaccatgcta atgccagagc gttttcgcat      180

ctggcttcaa aactgatcga aacggaggtg gacccatccg acacgatcct tgacattgga      240

atagtcagca tagtacattt catctgacta atactacaac accaccacca tgaatagagg      300

attctttaac atgctcggcc gccgcccctt cccggccccc actgccatgt ggaggccgcg      360

gagaaggagg caggcggccc cgggaagcgg agctactaac ttcagcctgc tgaagcaggc      420

tggagacgtg gaggagaacc ctggacctga gaaagttcac gttgacatcg aggaagacag      480

cccattcctc agagctttgc agcggagctt cccgcagttt gaggtagaag ccaagcaggt      540

cactgataat gaccatgcta atgccagagc gttttcgcat ctggcttcaa aactgatcga      600

aacggaggtg gacccatccg acacgatcct tgacattgga agtgcgcccg cccgcagaat      660

gtattctaag cacaagtatc attgtatctg tccgatgaga tgtgcggaag atccggacag      720

attgtataag tatgcaacta agctgaagaa aaactgtaag gaaataactg ataaggaatt      780

ggacaagaaa atgaaggagc tcgccgccgt catgagcgac cctgacctgg aaactgagac      840

tatgtgcctc cacgacgacg agtcgtgtcg ctacgaaggg caagtcgctg tttaccagga      900

tgtatacgcg gttgacggac cgacaagtct ctatcaccaa gccaataagg gagttagagt      960

cgcctactgg ataggctttg acaccacccc ttttatgttt aagaacttgg ctggagcata     1020

tccatcatac tctaccaact gggccgacga aaccgtgtta acggctcgta acataggcct     1080

atgcagctct gacgttatgg agcggtcacg tagagggatg tccattctta gaaagaagta     1140

tttgaaacca tccaacaatg ttctattctc tgttggctcg accatctacc acgagaagag     1200

ggacttactg aggagctggc acctgccgtc tgtatttcac ttacgtggca agcaaaatta     1260

cacatgtcgg tgtgagacta tagttagttg cgacgggtac gtcgttaaaa gaatagctat     1320

cagtccaggc ctgtatggga agccttcagg ctatgctgct acgatgcacc gcgagggatt     1380

cttgtgctgc aaagtgacag acacattgaa cggggagagg gtctcttttc ccgtgtgcac     1440

gtatgtgcca gctacattgt gtgaccaaat gactggcata ctggcaacag atgtcagtgc     1500

ggacgacgcg caaaaactgc tggttgggct caaccagcgt atagtcgtca acggtcgcac     1560

ccagagaaac accaatacca tgaaaaatta ccttttgccc gtagtggccc aggcatttgc     1620

taggtgggca aaggaatata aggaagatca agaagatgaa aggccactag gactacgaga     1680

tagacagtta gtcatggggt gttgttgggc ttttagaagg cacaagataa catctattta     1740

taagcgcccg gatacccaaa ccatcatcaa agtgaacagc gatttccact cattcgtgct     1800

gcccaggata ggcagtaaca cattggagat cgggctgaga acaagaatca ggaaaatgtt     1860

agaggagcac aaggagccgt cacctctcat taccgccgag gacgtacaag aagctaagtg     1920

cgcagccgat gaggctaagg aggtgcgtga agccgaggag ttgcgcgcag ctctaccacc     1980

tttggcagct gatgttgagg agcccactct ggaagccgat gtcgacttga tgttacaaga     2040

ggctggggcc ggctcagtgg agacacctcg tggcttgata aaggttacca gctacgatgg     2100

cgaggacaag atcggctctt acgctgtgct ttctccgcag gctgtactca agagtgaaaa     2160

attatcttgc atccaccctc tcgctgaaca agtcatagtg ataacacact ctggccgaaa     2220

agggcgttat gccgtggaac cataccatgg taaagtagtg gtgccagagg gacatgcaat     2280

acccgtccag gactttcaag ctctgagtga aagtgccacc attgtgtaca acgaacgtga     2340

gttcgtaaac aggtacctgc accatattgc cacacatgga ggagcgctga acactgatga     2400

agaatattac aaaactgtca agcccagcga gcacgacggc gaatacctgt acgacatcga     2460

caggaaacag tgcgtcaaga aagaactagt cactgggcta gggctcacag gcgagctggt     2520

ggatcctccc ttccatgaat tcgcctacga gagtctgaga acacgaccag ccgctcctta     2580

ccaagtacca accatagggg tgtatggcgt gccaggatca ggcaagtctg gcatcattaa     2640

aagcgcagtc accaaaaaag atctagtggt gagcgccaag aaagaaaact gtgcagaaat     2700

tataagggac gtcaagaaaa tgaaagggct ggacgtcaat gccagaactg tggactcagt     2760

gctcttgaat ggatgcaaac accccgtaga gaccctgtat attgacgaag cttttgcttg     2820

tcatgcaggt actctcagag cgctcatagc cattataaga cctaaaaagg cagtgctctg     2880

cggggatccc aaacagtgcg gtttttttaa catgatgtgc ctgaaagtgc attttaacca     2940

cgagatttgc acacaagtct tccacaaaag catctctcgc cgttgcacta aatctgtgac     3000

ttcggtcgtc tcaaccttgt tttacgacaa aaaaatgaga acgacgaatc cgaaagagac     3060

taagattgtg attgacacta ccggcagtac caaacctaag caggacgatc tcattctcac     3120

ttgtttcaga gggtgggtga agcagttgca aatagattac aaaggcaacg aaataatgac     3180

ggcagctgcc tctcaagggc tgacccgtaa aggtgtgtat gccgttcggt acaaggtgaa     3240

tgaaaatcct ctgtacgcac ccacctctga acatgtgaac gtcctactga cccgcacgga     3300

ggaccgcatc gtgtggaaaa cactagccgg cgacccatgg ataaaaacac tgactgccaa     3360

gtaccctggg aatttcactg ccacgataga ggagtggcaa gcagagcatg atgccatcat     3420

gaggcacatc ttggagagac cggaccctac cgacgtcttc cagaataagg caaacgtgtg     3480

ttgggccaag gctttagtgc cggtgctgaa gaccgctggc atagacatga ccactgaaca     3540

atggaacact gtggattatt ttgaaacgga caaagctcac tcagcagaga tagtattgaa     3600

ccaactatgc gtgaggttct ttggactcga tctggactcc ggtctatttt ctgcacccac     3660

tgttccgtta tccattagga ataatcactg ggataactcc ccgtcgccta acatgtacgg     3720

gctgaataaa gaagtggtcc gtcagctctc tcgcaggtac ccacaactgc ctcgggcagt     3780

tgccactgga agagtctatg acatgaacac tggtacactg cgcaattatg atccgcgcat     3840

aaacctagta cctgtaaaca gaagactgcc tcatgcttta gtcctccacc ataatgaaca     3900

cccacagagt gacttttctt cattcgtcag caaattgaag ggcagaactg tcctggtggt     3960

cggggaaaag ttgtccgtcc caggcaaaat ggttgactgg ttgtcagacc ggcctgaggc     4020

taccttcaga gctcggctgg atttaggcat cccaggtgat gtgcccaaat atgacataat     4080

atttgttaat gtgaggaccc catataaata ccatcactat cagcagtgtg aagaccatgc     4140

cattaagctt agcatgttga ccaagaaagc ttgtctgcat ctgaatcccg gcggaacctg     4200

tgtcagcata ggttatggtt acgctgacag ggccagcgaa agcatcattg gtgctatagc     4260

gcggcagttc aagttttccc gggtatgcaa accgaaatcc tcacttgaag agacggaagt     4320

tctgtttgta ttcattgggt acgatcgcaa ggcccgtacg cacaatcctt acaagctttc     4380

atcaaccttg accaacattt atacaggttc cagactccac gaagccggat gtgcaccctc     4440

atatcatgtg gtgcgagggg atattgccac ggccaccgaa ggagtgatta taaatgctgc     4500

taacagcaaa ggacaacctg gcggaggggt gtgcggagcg ctgtataaga aattcccgga     4560

aagcttcgat ttacagccga tcgaagtagg aaaagcgcga ctggtcaaag gtgcagctaa     4620

acatatcatt catgccgtag gaccaaactt caacaaagtt tcggaggttg aaggtgacaa     4680

acagttggca gaggcttatg agtccatcgc taagattgtc aacgataaca attacaagtc     4740

agtagcgatt ccactgttgt ccaccggcat cttttccggg aacaaagatc gactaaccca     4800

atcattgaac catttgctga cagctttaga caccactgat gcagatgtag ccatatactg     4860

cagggacaag aaatgggaaa tgactctcaa ggaagcagtg gctaggagag aagcagtgga     4920

ggagatatgc atatccgacg actcttcagt gacagaacct gatgcagagc tggtgagggt     4980

gcatccgaag agttctttgg ctggaaggaa gggctacagc acaagcgatg gcaaaacttt     5040

ctcatatttg gaagggacca agtttcacca ggcggccaag gatatagcag aaattaatgc     5100

catgtggccc gttgcaacgg aggccaatga gcaggtatgc atgtatatcc tcggagaaag     5160

catgagcagt attaggtcga aatgccccgt cgaagagtcg gaagcctcca caccacctag     5220

cacgctgcct tgcttgtgca tccatgccat gactccagaa agagtacagc gcctaaaagc     5280

ctcacgtcca gaacaaatta ctgtgtgctc atcctttcca ttgccgaagt atagaatcac     5340

tggtgtgcag aagatccaat gctcccagcc tatattgttc tcaccgaaag tgcctgcgta     5400

tattcatcca aggaagtatc tcgtggaaac accaccggta gacgagactc cggagccatc     5460

ggcagagaac caatccacag aggggacacc tgaacaacca ccacttataa ccgaggatga     5520

gaccaggact agaacgcctg agccgatcat catcgaagag gaagaagagg atagcataag     5580

tttgctgtca gatggcccga cccaccaggt gctgcaagtc gaggcagaca ttcacgggcc     5640

gccctctgta tctagctcat cctggtccat tcctcatgca tccgactttg atgtggacag     5700

tttatccata cttgacaccc tggagggagc tagcgtgacc agcggggcaa cgtcagccga     5760

gactaactct tacttcgcaa agagtatgga gtttctggcg cgaccggtgc ctgcgcctcg     5820

aacagtattc aggaaccctc cacatcccgc tccgcgcaca agaacaccgt cacttgcacc     5880

cagcagggcc tgctcgagaa ccagcctagt ttccaccccg ccaggcgtga atagggtgat     5940

cactagagag gagctcgagg cgcttacccc gtcacgcact cctagcaggt cggtctcgag     6000

aaccagcctg gtctccaacc cgccaggcgt aaatagggtg attacaagag aggagtttga     6060

ggcgttcgta gcacaacaac aatgacggtt tgatgcgggt gcatacatct tttcctccga     6120

caccggtcaa gggcatttac aacaaaaatc agtaaggcaa acggtgctat ccgaagtggt     6180

gttggagagg accgaattgg agatttcgta tgccccgcgc ctcgaccaag aaaaagaaga     6240

attactacgc aagaaattac agttaaatcc cacacctgct aacagaagca gataccagtc     6300

caggaaggtg gagaacatga aagccataac agctagacgt attctgcaag gcctagggca     6360

ttatttgaag gcagaaggaa aagtggagtg ctaccgaacc ctgcatcctg ttcctttgta     6420

ttcatctagt gtgaaccgtg ccttttcaag ccccaaggtc gcagtggaag cctgtaacgc     6480

catgttgaaa gagaactttc cgactgtggc ttcttactgt attattccag agtacgatgc     6540

ctatttggac atggttgacg gagcttcatg ctgcttagac actgccagtt tttgccctgc     6600

aaagctgcgc agctttccaa agaaacactc ctatttggaa cccacaatac gatcggcagt     6660

gccttcagcg atccagaaca cgctccagaa cgtcctggca gctgccacaa aaagaaattg     6720

caatgtcacg caaatgagag aattgcccgt attggattcg gcggccttta atgtggaatg     6780

cttcaagaaa tatgcgtgta ataatgaata ttgggaaacg tttaaagaaa accccatcag     6840

gcttactgaa gaaaacgtgg taaattacat taccaaatta aaaggaccaa aagctgctgc     6900

tctttttgcg aagacacata atttgaatat gttgcaggac ataccaatgg acaggtttgt     6960

aatggactta aagagagacg tgaaagtgac tccaggaaca aaacatactg aagaacggcc     7020

caaggtacag gtgatccagg ctgccgatcc gctagcaaca gcgtatctgt gcggaatcca     7080

ccgagagctg gttaggagat taaatgcggt cctgcttccg aacattcata cactgtttga     7140

tatgtcggct gaagactttg acgctattat agccgagcac ttccagcctg gggattgtgt     7200

tctggaaact gacatcgcgt cgtttgataa aagtgaggac gacgccatgg ctctgaccgc     7260

gttaatgatt ctggaagact taggtgtgga cgcagagctg ttgacgctga ttgaggcggc     7320

tttcggcgaa atttcatcaa tacatttgcc cactaaaact aaatttaaat tcggagccat     7380

gatgaaatct ggaatgttcc tcacactgtt tgtgaacaca gtcattaaca ttgtaatcgc     7440

aagcagagtg ttgagagaac ggctaaccgg atcaccatgt gcagcattca ttggagatga     7500

caatatcgtg aaaggagtca aatcggacaa attaatggca gacaggtgcg ccacctggtt     7560

gaatatggaa gtcaagatta tagatgctgt ggtgggcgag aaagcgcctt atttctgtgg     7620

agggtttatt ttgtgtgact ccgtgaccgg cacagcgtgc cgtgtggcag accccctaaa     7680

aaggctgttt aagcttggca aacctctggc agcagacgat gaacatgatg atgacaggag     7740

aagggcattg catgaagagt caacacgctg gaaccgagtg ggtattcttt cagagctgtg     7800

caaggcagta gaatcaaggt atgaaaccgt aggaacttcc atcatagtta tggccatgac     7860

tactctagct agcagtgtta aatcattcag ctacctgaga ggggccccta taactctcta     7920

cggctaacct gaatggacta cgacatagtc tagtccgcca agatatcatg ttcgtgtttc     7980

tggtgctgct gcctctggtg tccagccaat gcgtgaacct gaccacaaga acccagctgc     8040

ctccagccta caccaacagc tttaccagag gcgtgtacta ccccgacaag gtgttcagat     8100

ccagcgtgct gcactctacc caggacctgt tcctgccttt cttcagcaac gtgacctggt     8160

tccacgccat ccacgtgtcc ggcaccaatg gcaccaagag attcgacaac cccgtgctgc     8220

ccttcaacga cggggtgtac tttgccagca ccgagaagtc caacatcatc agaggctgga     8280

tcttcggcac cacactggac agcaagaccc agagcctgct gatcgtgaac aacgccacca     8340

acgtggtcat caaagtgtgc gagttccagt tctgcaacga ccccttcctg ggcgtctact     8400

atcacaagaa caacaagagc tggatggaaa gcgagttccg ggtgtacagc agcgccaaca     8460

actgcacctt tgaatacgtg tcccagcctt tcctgatgga cctggaaggc aagcagggca     8520

acttcaagaa cctgcgcgag ttcgtgttca agaacatcga cggctacttc aagatctaca     8580

gcaagcacac ccctatcaac ctcgtgcggg atctgcctca gggcttctct gctctggaac     8640

ccctggtgga tctgcccatc ggcatcaaca tcacccggtt tcagacactg ctggccctgc     8700

acagaagcta cctgacacct ggcgatagca gcagcggatg gacagctggt gccgccgctt     8760

actatgtggg ctacctgcag cctagaacct ttctgctgaa gtacaacgag aacggcacca     8820

tcaccgacgc cgtggattgt gctctggatc ctctgagcga gacaaagtgc accctgaagt     8880

ccttcaccgt ggaaaagggc atctaccaga ccagcaactt ccgggtgcag cccaccgaat     8940

ccatcgtgcg gttccccaat atcaccaatc tgtgcccctt cggcgaggtg ttcaatgcca     9000

ccagattcgc ctctgtgtac gcctggaacc ggaagcggat cagcaattgc gtggccgact     9060

actccgtgct gtacaactcc gccagcttca gcaccttcaa gtgctacggc gtgtccccta     9120

ccaagctgaa cgacctgtgc ttcacaaacg tgtacgccga cagcttcgtg atccggggag     9180

atgaagtgcg gcagattgcc cctggacaga ctggcaagat cgccgactac aactacaagc     9240

tgcccgacga cttcaccggc tgtgtgattg cctggaacag caacaacctg gactccaaag     9300

tcggcggcaa ctacaattac ctgtaccggc tgttccggaa gtccaatctg aagcccttcg     9360

agcgggacat ctccaccgag atctatcagg ccggcagcac cccttgtaac ggcgtggaag     9420

gcttcaactg ctacttccca ctgcagtcct acggctttca gcccacaaat ggcgtgggct     9480

atcagcccta cagagtggtg gtgctgagct tcgaactgct gcatgcccct gccacagtgt     9540

gcggccctaa gaaaagcacc aatctcgtga agaacaaatg cgtgaacttc aacttcaacg     9600

gcctgaccgg caccggcgtg ctgacagaga gcaacaagaa gttcctgcca ttccagcagt     9660

ttggccggga tatcgccgat accacagacg ccgttagaga tccccagaca ctggaaatcc     9720

tggacatcac cccttgcagc ttcggcggag tgtctgtgat cacccctggc accaacacca     9780

gcaatcaggt ggcagtgctg taccaggacg tgaactgtac cgaagtgccc gtggccattc     9840

acgccgatca gctgacacct acatggcggg tgtactccac cggcagcaat gtgtttcaga     9900

ccagagccgg ctgtctgatc ggagccgagc acgtgaacaa tagctacgag tgcgacatcc     9960

ccatcggcgc tggcatctgt gccagctacc agacacagac aaacagcccc agcagagccg    10020

gatctgtggc cagccagagc atcattgcct acacaatgtc tctgggcgcc gagaacagcg    10080

tggcctactc caacaactct atcgctatcc ccaccaactt caccatcagc gtgaccacag    10140

agatcctgcc tgtgtccatg accaagacca gcgtggactg caccatgtac atctgcggcg    10200

attccaccga gtgctccaac ctgctgctgc agtacggcag cttctgcacc cagctgaata    10260

gagccctgac agggatcgcc gtggaacagg acaagaacac ccaagaggtg ttcgcccaag    10320

tgaagcagat ctacaagacc cctcctatca aggacttcgg cggcttcaat ttcagccaga    10380

ttctgcccga tcctagcaag cccagcaagc ggagcttcat cgaggacctg ctgttcaaca    10440

aagtgacact ggccgacgcc ggcttcatca agcagtatgg cgattgtctg ggcgacattg    10500

ccgccaggga tctgatttgc gcccagaagt ttaacggact gacagtgctg cctcctctgc    10560

tgaccgatga gatgatcgcc cagtacacat ctgccctgct ggccggcaca atcacaagcg    10620

gctggacatt tggagctggc gccgctctgc agatcccctt tgctatgcag atggcctacc    10680

ggttcaacgg catcggagtg acccagaatg tgctgtacga gaaccagaag ctgatcgcca    10740

accagttcaa cagcgccatc ggcaagatcc aggacagcct gagcagcaca gcaagcgccc    10800

tgggaaagct gcaggacgtg gtcaaccaga atgcccaggc actgaacacc ctggtcaagc    10860

agctgtcctc caacttcggc gccatcagct ctgtgctgaa cgatatcctg agcagactgg    10920

accctcctga ggccgaggtg cagatcgaca gactgatcac cggaaggctg cagtccctgc    10980

agacctacgt tacccagcag ctgatcagag ccgccgagat tagagcctct gccaatctgg    11040

ccgccaccaa gatgtctgag tgtgtgctgg gccagagcaa gagagtggac ttttgcggca    11100

agggctacca cctgatgagc ttccctcagt ctgcccctca cggcgtggtg tttctgcacg    11160

tgacttatgt gcccgctcaa gagaagaatt tcaccaccgc tccagccatc tgccacgacg    11220

gcaaagccca ctttcctaga gaaggcgtgt tcgtgtccaa cggcacccat tggttcgtga    11280

cacagcggaa cttctacgag ccccagatca tcaccaccga caacaccttc gtgtctggca    11340

actgcgacgt cgtgatcggc attgtgaaca ataccgtgta cgaccctctg cagcccgagc    11400

tggacagctt caaagaggaa ctggacaagt actttaagaa ccacacaagc cccgacgtgg    11460

acctgggcga tatcagcgga atcaatgcca gcgtcgtgaa catccagaaa gagatcgacc    11520

ggctgaacga ggtggccaag aatctgaacg agagcctgat cgacctgcaa gaactgggaa    11580

aatacgagca gtacatcaag tggccttggt acatctggct gggctttatc gccggactga    11640

ttgccatcgt gatggtcaca atcatgctgt gttgcatgac cagctgctgt agctgcctga    11700

agggctgttg tagctgtggc agctgctgca agttcgacga ggacgattct gagcccgtgc    11760

tgaagggcgt gaaactgcac tacacatgat aaggcgcgcc gtttaaacgg ccggccttaa    11820

ttaagtaacg atacagcagc aattggcaag ctgcttacat agaactcgcg gcgattggca    11880

tgccgcttta aaatttttat tttatttttc ttttcttttc cgaatcggat tttgttttta    11940

atatttcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa                  11987


