                         SEQUENCE LISTING

<110>  iOmx Therapeutics AG
 
<120>  INTRACELLULAR KINASE ASSOCIATED WITH RESISTANCE AGAINST T-CELL
       MEDIATED CYTOTOXICITY, AND USES THEREOF

<130>  I33723WO

<150>  EP20175030.4
<151>  2020-05-15

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  385
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Leu Ala Pro Ser Thr 
            340                 345                 350         


Leu Cys Ser Phe Ile Ser Ser Ser Ser Gly Val Ser Gly Val Gly Ala 
        355                 360                 365             


Glu Arg Arg Pro Arg Pro Thr Thr Val Thr Ala Val His Ser Gly Ser 
    370                 375                 380                 


Lys 
385 


<210>  2
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Glu Asn Gly Glu Ser Ser Ser Ser Trp Lys Lys Gln Ala 
1               5                   10                  15      


Glu Asp Ile Lys Lys Ile Phe Glu Phe Lys Glu Thr Leu Gly Thr Gly 
            20                  25                  30          


Ala Phe Ser Glu Val Val Leu Ala Glu Glu Lys Ala Thr Gly Lys Leu 
        35                  40                  45              


Phe Ala Val Lys Cys Ile Pro Lys Lys Ala Leu Lys Gly Lys Glu Ser 
    50                  55                  60                  


Ser Ile Glu Asn Glu Ile Ala Val Leu Arg Lys Ile Lys His Glu Asn 
65                  70                  75                  80  


Ile Val Ala Leu Glu Asp Ile Tyr Glu Ser Pro Asn His Leu Tyr Leu 
                85                  90                  95      


Val Met Gln Leu Val Ser Gly Gly Glu Leu Phe Asp Arg Ile Val Glu 
            100                 105                 110         


Lys Gly Phe Tyr Thr Glu Lys Asp Ala Ser Thr Leu Ile Arg Gln Val 
        115                 120                 125             


Leu Asp Ala Val Tyr Tyr Leu His Arg Met Gly Ile Val His Arg Asp 
    130                 135                 140                 


Leu Lys Pro Glu Asn Leu Leu Tyr Tyr Ser Gln Asp Glu Glu Ser Lys 
145                 150                 155                 160 


Ile Met Ile Ser Asp Phe Gly Leu Ser Lys Met Glu Gly Lys Gly Asp 
                165                 170                 175     


Val Met Ser Thr Ala Cys Gly Thr Pro Gly Tyr Val Ala Pro Glu Val 
            180                 185                 190         


Leu Ala Gln Lys Pro Tyr Ser Lys Ala Val Asp Cys Trp Ser Ile Gly 
        195                 200                 205             


Val Ile Ala Tyr Ile Leu Leu Cys Gly Tyr Pro Pro Phe Tyr Asp Glu 
    210                 215                 220                 


Asn Asp Ser Lys Leu Phe Glu Gln Ile Leu Lys Ala Glu Tyr Glu Phe 
225                 230                 235                 240 


Asp Ser Pro Tyr Trp Asp Asp Ile Ser Asp Ser Ala Lys Asp Phe Ile 
                245                 250                 255     


Arg Asn Leu Met Glu Lys Asp Pro Asn Lys Arg Tyr Thr Cys Glu Gln 
            260                 265                 270         


Ala Ala Arg His Pro Trp Ile Ala Gly Asp Thr Ala Leu Asn Lys Asn 
        275                 280                 285             


Ile His Glu Ser Val Ser Ala Gln Ile Arg Lys Asn Phe Ala Lys Ser 
    290                 295                 300                 


Lys Trp Arg Gln Ala Phe Asn Ala Thr Ala Val Val Arg His Met Arg 
305                 310                 315                 320 


Lys Leu His Leu Gly Ser Ser Leu Asp Ser Ser Asn Ala Ser Val Ser 
                325                 330                 335     


Ser Ser Leu Ser Leu Ala Ser Gln Lys Asp Cys Ala Tyr Val Ala Lys 
            340                 345                 350         


Pro Glu Ser Leu Ser 
        355         


<210>  3
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  siRNA sequence targeting CAMK1D

<400>  3
ugaaguguau cccuaagaa                                                    19


<210>  4
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  siRNA sequence targeting CAMK1D

<400>  4
caaaucaccu guacuuggu                                                    19


<210>  5
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  siRNA sequence targeting CAMK1D

<400>  5
ccgaaaaucu cuuguacua                                                    19


<210>  6
<211>  19
<212>  RNA
<213>  artificial

<220>
<223>  siRNA sequence targeting CAMK1D

<400>  6
gagaaggacc cgaauaaaa                                                    19


<210>  7
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  gRNA sequence for targeting mouse CAMK1D by gene editing

<400>  7
tcgatcggat agtggagaag                                                   20


<210>  8
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  gRNA sequence for targeting mouse CAMK1D by gene editing

<400>  8
ggagatagta tacggcatcc                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  gRNA sequence for targeting CAMK1D by gene editing

<400>  9
tagccgagga gaaagctact                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  10
ggagatagta tacggcatcc                                                   20


<210>  11
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ala Asp Gln Leu Thr Glu Glu Gln Ile Ala Glu Phe Lys Glu Ala 
1               5                   10                  15      


Phe Ser Leu Phe Asp Lys Asp Gly Asp Gly Thr Ile Thr Thr Lys Glu 
            20                  25                  30          


Leu Gly Thr Val Met Arg Ser Leu Gly Gln Asn Pro Thr Glu Ala Glu 
        35                  40                  45              


Leu Gln Asp Met Ile Asn Glu Val Asp Ala Asp Gly Asn Gly Thr Ile 
    50                  55                  60                  


Asp Phe Pro Glu Phe Leu Thr Met Met Ala Arg Lys Met Lys Asp Thr 
65                  70                  75                  80  


Asp Ser Glu Glu Glu Ile Arg Glu Ala Phe Arg Val Phe Asp Lys Asp 
                85                  90                  95      


Gly Asn Gly Tyr Ile Ser Ala Ala Glu Leu Arg His Val Met Thr Asn 
            100                 105                 110         


Leu Gly Glu Lys Leu Thr Asp Glu Glu Val Asp Glu Met Ile Arg Glu 
        115                 120                 125             


Ala Asp Ile Asp Gly Asp Gly Gln Val Asn Tyr Glu Glu Phe Val Gln 
    130                 135                 140                 


Met Met Thr Ala Lys 
145                 


<210>  12
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Val Phe Asp Leu Leu Arg Lys Gly Pro Val Met Glu 
225                 230                 235                 240 


Val Pro Cys Asp Lys Pro Phe Ser Glu Glu Gln Ala Arg Leu Tyr Leu 
                245                 250                 255     


Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu His Cys Gln Lys Ile Val 
            260                 265                 270         


His Arg Asp Ile Lys Pro Ser Asn Leu Leu Leu Gly Asp Asp Gly His 
        275                 280                 285             


Val Lys Ile Ala Asp Phe Gly Val Ser Asn Gln Phe Glu Gly Asn Asp 
    290                 295                 300                 


Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro Ala Phe Met Ala Pro Glu 
305                 310                 315                 320 


Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser Gly Lys Ala Leu Asp Val 
                325                 330                 335     


Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe Val Tyr Gly Lys Cys Pro 
            340                 345                 350         


Phe Ile Asp Asp Phe Ile Leu Ala Leu His Arg Lys Ile Lys Asn Glu 
        355                 360                 365             


Pro Val Val Phe Pro Glu Glu Pro Glu Ile Ser Glu Glu Leu Lys Asp 
    370                 375                 380                 


Leu Ile Leu Lys Met Leu Asp Lys Asn Pro Glu Thr Arg Ile Gly Val 
385                 390                 395                 400 


Pro Asp Ile Lys Leu His Pro Trp Val Thr Lys Asn Gly Glu Glu Pro 
                405                 410                 415     


Leu Pro Ser Glu Glu Glu His Cys Ser Val Val Glu Val Thr Glu Glu 
            420                 425                 430         


Glu Val Lys Asn Ser Val Arg Leu Ile Pro Ser Trp Thr Thr Val Ile 
        435                 440                 445             


Leu Val Lys Ser Met Leu Arg Lys Arg Ser Phe Gly Asn Pro Phe Glu 
    450                 455                 460                 


Pro Gln Ala Arg Arg Glu Glu Arg Ser Met Ser Ala Pro Gly Asn Leu 
465                 470                 475                 480 


Leu Val Lys Glu Gly Phe Gly Glu Gly Gly Lys Ser Pro Glu Leu Pro 
                485                 490                 495     


Gly Val Gln Glu Asp Glu Ala Ala Ser 
            500                 505 


<210>  13
<211>  520
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Gly Gly Pro Ala Val Cys Cys Gln Asp Pro Arg Ala Glu Leu 
1               5                   10                  15      


Val Glu Arg Val Ala Ala Ile Asp Val Thr His Leu Glu Glu Ala Asp 
            20                  25                  30          


Gly Gly Pro Glu Pro Thr Arg Asn Gly Val Asp Pro Pro Pro Arg Ala 
        35                  40                  45              


Arg Ala Ala Ser Val Ile Pro Gly Ser Thr Ser Arg Leu Leu Pro Ala 
    50                  55                  60                  


Arg Pro Ser Leu Ser Ala Arg Lys Leu Ser Leu Gln Glu Arg Pro Ala 
65                  70                  75                  80  


Gly Ser Tyr Leu Glu Ala Gln Ala Gly Pro Tyr Ala Thr Gly Pro Ala 
                85                  90                  95      


Ser His Ile Ser Pro Arg Ala Trp Arg Arg Pro Thr Ile Glu Ser His 
            100                 105                 110         


His Val Ala Ile Ser Asp Ala Glu Asp Cys Val Gln Leu Asn Gln Tyr 
        115                 120                 125             


Lys Leu Gln Ser Glu Ile Gly Lys Gly Ala Tyr Gly Val Val Arg Leu 
    130                 135                 140                 


Ala Tyr Asn Glu Ser Glu Asp Arg His Tyr Ala Met Lys Val Leu Ser 
145                 150                 155                 160 


Lys Lys Lys Leu Leu Lys Gln Tyr Gly Phe Pro Arg Arg Pro Pro Pro 
                165                 170                 175     


Arg Gly Ser Gln Ala Ala Gln Gly Gly Pro Ala Lys Gln Leu Leu Pro 
            180                 185                 190         


Leu Glu Arg Val Tyr Gln Glu Ile Ala Ile Leu Lys Lys Leu Asp His 
        195                 200                 205             


Val Asn Val Val Lys Leu Ile Glu Val Leu Asp Asp Pro Ala Glu Asp 
    210                 215                 220                 


Asn Leu Tyr Leu Ala Leu Gln Asn Gln Ala Gln Asn Ile Gln Leu Asp 
225                 230                 235                 240 


Ser Thr Asn Ile Ala Lys Pro His Ser Leu Leu Pro Ser Glu Gln Gln 
                245                 250                 255     


Asp Ser Gly Ser Thr Trp Ala Ala Arg Ser Val Phe Asp Leu Leu Arg 
            260                 265                 270         


Lys Gly Pro Val Met Glu Val Pro Cys Asp Lys Pro Phe Ser Glu Glu 
        275                 280                 285             


Gln Ala Arg Leu Tyr Leu Arg Asp Val Ile Leu Gly Leu Glu Tyr Leu 
    290                 295                 300                 


His Cys Gln Lys Ile Val His Arg Asp Ile Lys Pro Ser Asn Leu Leu 
305                 310                 315                 320 


Leu Gly Asp Asp Gly His Val Lys Ile Ala Asp Phe Gly Val Ser Asn 
                325                 330                 335     


Gln Phe Glu Gly Asn Asp Ala Gln Leu Ser Ser Thr Ala Gly Thr Pro 
            340                 345                 350         


Ala Phe Met Ala Pro Glu Ala Ile Ser Asp Ser Gly Gln Ser Phe Ser 
        355                 360                 365             


Gly Lys Ala Leu Asp Val Trp Ala Thr Gly Val Thr Leu Tyr Cys Phe 
    370                 375                 380                 


Val Tyr Gly Lys Cys Pro Phe Ile Asp Asp Phe Ile Leu Ala Leu His 
385                 390                 395                 400 


Arg Lys Ile Lys Asn Glu Pro Val Val Phe Pro Glu Glu Pro Glu Ile 
                405                 410                 415     


Ser Glu Glu Leu Lys Asp Leu Ile Leu Lys Met Leu Asp Lys Asn Pro 
            420                 425                 430         


Glu Thr Arg Ile Gly Val Pro Asp Ile Lys Leu His Pro Trp Val Thr 
        435                 440                 445             


Lys Asn Gly Glu Glu Pro Leu Pro Ser Glu Glu Glu His Cys Ser Val 
    450                 455                 460                 


Val Glu Val Thr Glu Glu Glu Val Lys Asn Ser Val Arg Leu Ile Pro 
465                 470                 475                 480 


Ser Trp Thr Thr Val Ile Leu Val Lys Ser Met Leu Arg Lys Arg Ser 
                485                 490                 495     


Phe Gly Asn Pro Phe Glu Pro Gln Ala Arg Arg Glu Glu Arg Ser Met 
            500                 505                 510         


Ser Ala Pro Gly Asn Leu Leu Val 
        515                 520 


