                         SEQUENCE LISTING

<110>  Universit de Tours
       Centre Hospitalier Rgional Universitaire de Tours
       Institut National de la Sant et de la Recherche Mdicale
 
<120>  NOUVELLES COMPOSITIONS IMMUNOGENES ET LEUR APPLICATION POUR LA 
       PREPARATION DE VACCINS CONTRE L'HEPATITE C ET L'HEPATITE B

<130>  WOB 20 AW TOU SERO

<150>  FR 2004848
<151>  2020-05-15

<160>  53    

<170>  PatentIn version 3.5

<210>  1
<211>  684
<212>  DNA
<213>  Hepatitis B virus


<220>
<221>  CDS
<222>  (1)..(684)
<223>  Protine S du virus HBV de srotype adw

<400>  1
atg gag aac atc aca tca gga ttc cta gga ccc ctg ctc gtg tta cag         48
Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln           
1               5                   10                  15                

gcg ggg ttt ttc ttg ttg aca aga atc ctc aca ata ccg cag agt cta         96
Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu           
            20                  25                  30                    

gac tcg tgg tgg act tct ctc aat ttt cta ggg gga tct ccc gtg tgt        144
Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys           
        35                  40                  45                        

ctt ggc caa aat tcg cag tcc cca acc tcc aat cac tca cca acc tcc        192
Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser           
    50                  55                  60                            

tgt cct cca att tgt cct ggt tat cgc tgg atg tgt ctg cgg cgt ttt        240
Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe           
65                  70                  75                  80            

atc ata ttc ctc ttc atc ctg ctg cta tgc ctc atc ttc tta ttg gtt        288
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val           
                85                  90                  95                

ctt ctg gat tat caa ggt atg ttg ccc gtt tgt cct cta att cca gga        336
Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly           
            100                 105                 110                   

tca aca aca acc agt acg gga cca tgc aaa acc tgc acg act cct gct        384
Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala           
        115                 120                 125                       

caa ggc aac tct atg ttt ccc tca tgt tgc tgt aca aaa cct acg gat        432
Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp           
    130                 135                 140                           

gga aat tgc acc tgt att ccc atc cca tcg tcc tgg gct ttc gca aaa        480
Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys           
145                 150                 155                 160           

tac cta tgg gag tgg gcc tca gtc cgt ttc tct tgg ctc agt tta cta        528
Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu           
                165                 170                 175               

gtg cca ttt gtt cag tgg ttc gta ggg ctt tcc ccc act gtt tgg ctt        576
Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu           
            180                 185                 190                   

tca gct ata tgg atg atg tgg tat tgg ggg cca agt ctg tac agc atc        624
Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile           
        195                 200                 205                       

gtg agt ccc ttt ata ccg ctg tta cca att ttc ttt tgt ctc tgg gta        672
Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val           
    210                 215                 220                           

tac att taa taa                                                        684
Tyr Ile                                                                   
225                                                                       


<210>  2
<211>  226
<212>  PRT
<213>  Hepatitis B virus

<400>  2

Met Glu Asn Ile Thr Ser Gly Phe Leu Gly Pro Leu Leu Val Leu Gln 
1               5                   10                  15      


Ala Gly Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu 
            20                  25                  30          


Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro Val Cys 
        35                  40                  45              


Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 
    50                  55                  60                  


Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 
65                  70                  75                  80  


Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 
                85                  90                  95      


Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro Gly 
            100                 105                 110         


Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala 
        115                 120                 125             


Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp 
    130                 135                 140                 


Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys 
145                 150                 155                 160 


Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser Leu Leu 
                165                 170                 175     


Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 
            180                 185                 190         


Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 
        195                 200                 205             


Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 
    210                 215                 220                 


Tyr Ile 
225     


<210>  3
<211>  618
<212>  DNA
<213>  Hepatitis B virus


<220>
<221>  CDS
<222>  (1)..(618)
<223>  Protine S dlte du virus HBV de srotype adw

<400>  3
aca aga atc ctc aca ata ccg cag agt cta gac tcg tgg tgg act tct         48
Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser           
1               5                   10                  15                

ctc aat ttt cta ggg gga tct ccc gtg tgt ctt ggc caa aat tcg cag         96
Leu Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln           
            20                  25                  30                    

tcc cca acc tcc aat cac tca cca acc tcc tgt cct cca att tgt cct        144
Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro           
        35                  40                  45                        

ggt tat cgc tgg atg tgt ctg cgg cgt ttt atc ata ttc ctc ttc atc        192
Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile           
    50                  55                  60                            

ctg ctg cta tgc ctc atc ttc tta ttg gtt ctt ctg gat tat caa ggt        240
Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly           
65                  70                  75                  80            

atg ttg ccc gtt tgt cct cta att cca gga tca aca aca acc agt acg        288
Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr           
                85                  90                  95                

gga cca tgc aaa acc tgc acg act cct gct caa ggc aac tct atg ttt        336
Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe           
            100                 105                 110                   

ccc tca tgt tgc tgt aca aaa cct acg gat gga aat tgc acc tgt att        384
Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile           
        115                 120                 125                       

ccc atc cca tcg tcc tgg gct ttc gca aaa tac cta tgg gag tgg gcc        432
Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala           
    130                 135                 140                           

tca gtc cgt ttc tct tgg ctc agt tta cta gtg cca ttt gtt cag tgg        480
Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp           
145                 150                 155                 160           

ttc gta ggg ctt tcc ccc act gtt tgg ctt tca gct ata tgg atg atg        528
Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met           
                165                 170                 175               

tgg tat tgg ggg cca agt ctg tac agc atc gtg agt ccc ttt ata ccg        576
Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro           
            180                 185                 190                   

ctg tta cca att ttc ttt tgt ctc tgg gta tac att taa taa                618
Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile                           
        195                 200                                           


<210>  4
<211>  204
<212>  PRT
<213>  Hepatitis B virus

<400>  4

Thr Arg Ile Leu Thr Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser 
1               5                   10                  15      


Leu Asn Phe Leu Gly Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln 
            20                  25                  30          


Ser Pro Thr Ser Asn His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro 
        35                  40                  45              


Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile 
    50                  55                  60                  


Leu Leu Leu Cys Leu Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly 
65                  70                  75                  80  


Met Leu Pro Val Cys Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr 
                85                  90                  95      


Gly Pro Cys Lys Thr Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe 
            100                 105                 110         


Pro Ser Cys Cys Cys Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile 
        115                 120                 125             


Pro Ile Pro Ser Ser Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala 
    130                 135                 140                 


Ser Val Arg Phe Ser Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp 
145                 150                 155                 160 


Phe Val Gly Leu Ser Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met 
                165                 170                 175     


Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro 
            180                 185                 190         


Leu Leu Pro Ile Phe Phe Cys Leu Trp Val Tyr Ile 
        195                 200                 


<210>  5
<211>  648
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(648)
<223>  Protine E1 du virus HCV de gnotype 4a

<400>  5
atg aca ggg aat ctt cct ggt tgc tct ttt tct atc ttc ctt ttg gca         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ctt ctc tcg tgc ctg act gtc ccc gct tcg gcc gtt aac tac cgc aac         96
Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val Asn Tyr Arg Asn           
            20                  25                  30                    

acc tcg ggc atc tac cac atc acc aat gac tgc ccg aat tca agc ata        144
Thr Ser Gly Ile Tyr His Ile Thr Asn Asp Cys Pro Asn Ser Ser Ile           
        35                  40                  45                        

gtt tat gag gcc gac cat cac atc ttg cac ctt cca ggt tgc gtg ccc        192
Val Tyr Glu Ala Asp His His Ile Leu His Leu Pro Gly Cys Val Pro           
    50                  55                  60                            

tgc gtg aaa acg ggg aat cga tca cgt tgc tgg gtg gcc ctt act cct        240
Cys Val Lys Thr Gly Asn Arg Ser Arg Cys Trp Val Ala Leu Thr Pro           
65                  70                  75                  80            

act gtc gca gcg cca tac atc ggc gcg ccg ctt cac tct cta cgg agt        288
Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro Leu His Ser Leu Arg Ser           
                85                  90                  95                

cat gtg gat ctg atg gtg ggg gct gct acc gtt tgt tca gcc ctt tac        336
His Val Asp Leu Met Val Gly Ala Ala Thr Val Cys Ser Ala Leu Tyr           
            100                 105                 110                   

ata gga gat ttg tgt ggc ggc tta ttc ttg gct ggt cag gtg ttc tct        384
Ile Gly Asp Leu Cys Gly Gly Leu Phe Leu Ala Gly Gln Val Phe Ser           
        115                 120                 125                       

ttc cga cca cgg cgc cac tgg act acc cag gat tgc aat tgt tcc atc        432
Phe Arg Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Ile           
    130                 135                 140                           

tac aca ggg cac atc acc ggg cat aga atg gcc tgg ggc atg atg atg        480
Tyr Thr Gly His Ile Thr Gly His Arg Met Ala Trp Gly Met Met Met           
145                 150                 155                 160           

aac tgg agt cca aca act acc cta gtc ctt agc cag atc atg agg atc        528
Asn Trp Ser Pro Thr Thr Thr Leu Val Leu Ser Gln Ile Met Arg Ile           
                165                 170                 175               

cca ggt acc cta gta gac ttg ctc gct ggg ggc cac tgg ggt gtc ctt        576
Pro Gly Thr Leu Val Asp Leu Leu Ala Gly Gly His Trp Gly Val Leu           
            180                 185                 190                   

gtg gga gtg gct tat tac agc atg caa gct aat tgg gcc aaa gtc atc        624
Val Gly Val Ala Tyr Tyr Ser Met Gln Ala Asn Trp Ala Lys Val Ile           
        195                 200                 205                       

ttg gtc cta ttc ctc ttc gcg ggt                                        648
Leu Val Leu Phe Leu Phe Ala Gly                                           
    210                 215                                               


<210>  6
<211>  216
<212>  PRT
<213>  Hepatitis C virus

<400>  6

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val Asn Tyr Arg Asn 
            20                  25                  30          


Thr Ser Gly Ile Tyr His Ile Thr Asn Asp Cys Pro Asn Ser Ser Ile 
        35                  40                  45              


Val Tyr Glu Ala Asp His His Ile Leu His Leu Pro Gly Cys Val Pro 
    50                  55                  60                  


Cys Val Lys Thr Gly Asn Arg Ser Arg Cys Trp Val Ala Leu Thr Pro 
65                  70                  75                  80  


Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro Leu His Ser Leu Arg Ser 
                85                  90                  95      


His Val Asp Leu Met Val Gly Ala Ala Thr Val Cys Ser Ala Leu Tyr 
            100                 105                 110         


Ile Gly Asp Leu Cys Gly Gly Leu Phe Leu Ala Gly Gln Val Phe Ser 
        115                 120                 125             


Phe Arg Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Ile 
    130                 135                 140                 


Tyr Thr Gly His Ile Thr Gly His Arg Met Ala Trp Gly Met Met Met 
145                 150                 155                 160 


Asn Trp Ser Pro Thr Thr Thr Leu Val Leu Ser Gln Ile Met Arg Ile 
                165                 170                 175     


Pro Gly Thr Leu Val Asp Leu Leu Ala Gly Gly His Trp Gly Val Leu 
            180                 185                 190         


Val Gly Val Ala Tyr Tyr Ser Met Gln Ala Asn Trp Ala Lys Val Ile 
        195                 200                 205             


Leu Val Leu Phe Leu Phe Ala Gly 
    210                 215     


<210>  7
<211>  1137
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(1137)
<223>  Protine E2 du virus HCV de gnotype 4a

<400>  7
atg gct aat tgg gcc aaa gtc atc ttg gtc cta ttc ctc ttc gca ggg         48
Met Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly           
1               5                   10                  15                

gtt gac gct aac acc cac acg act gga ggc gcg gcc ggc cta caa act         96
Val Asp Ala Asn Thr His Thr Thr Gly Gly Ala Ala Gly Leu Gln Thr           
            20                  25                  30                    

cgt ggt ttt act ggg ctc ttc ctc cct gga gct aaa caa aac ttg cag        144
Arg Gly Phe Thr Gly Leu Phe Leu Pro Gly Ala Lys Gln Asn Leu Gln           
        35                  40                  45                        

ctc att aac acc aat ggg agc tgg cat ata aac agg act gcc ctc aac        192
Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn           
    50                  55                  60                            

tgc aat gac agc tta aac act ggg ttc ttg gct agc ttg ttc tac acc        240
Cys Asn Asp Ser Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr           
65                  70                  75                  80            

aac aag ttt aac agt tca ggg tgt cct gaa cga ctt gca agc tgc aga        288
Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg           
                85                  90                  95                

agc ctt gat act ttc aac caa ggc tgg ggc cca ctt ggg gtc gct aac        336
Ser Leu Asp Thr Phe Asn Gln Gly Trp Gly Pro Leu Gly Val Ala Asn           
            100                 105                 110                   

atc agt gac tct gat gac agg cct tat tgc tgg cac tac ccc cct cga        384
Ile Ser Asp Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg           
        115                 120                 125                       

ccg tgc ggg att gtg ccg gca cgc agt gtg tgt ggc ccc gtg tat tgc        432
Pro Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys           
    130                 135                 140                           

ttt act ccc agc ccc gtc gtg gtc ggg aca act gat cgc ctt ggg gtc        480
Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val           
145                 150                 155                 160           

ccc acg tac acc tgg ggg gag aat gag tct gat gcc ttc ctg ttg aac        528
Pro Thr Tyr Thr Trp Gly Glu Asn Glu Ser Asp Ala Phe Leu Leu Asn           
                165                 170                 175               

tcg acc agg ccg cca caa ggt gcg tgg ttt gga tgc gtg tgg atg aac        576
Ser Thr Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Val Trp Met Asn           
            180                 185                 190                   

agc acc ggg ttt aca aaa gcc tgt gga gct cct cca tgc gag gtt acc        624
Ser Thr Gly Phe Thr Lys Ala Cys Gly Ala Pro Pro Cys Glu Val Thr           
        195                 200                 205                       

aga gcc aat aat aaa acc tgg cac tgc ccc act gat tgt ttc agg aag        672
Arg Ala Asn Asn Lys Thr Trp His Cys Pro Thr Asp Cys Phe Arg Lys           
    210                 215                 220                           

cat ccg gag acc acc tat gcc aaa tgc gga tca ggc ccc tgg atc aca        720
His Pro Glu Thr Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Ile Thr           
225                 230                 235                 240           

cca cga tgc ttg att gac tac cgg tat cgg ctg tgg caa tta cca tgc        768
Pro Arg Cys Leu Ile Asp Tyr Arg Tyr Arg Leu Trp Gln Leu Pro Cys           
                245                 250                 255               

acc gtc aac tct tct gtc ttt aaa gtc agg acc tat atg gcc ggt aag        816
Thr Val Asn Ser Ser Val Phe Lys Val Arg Thr Tyr Met Ala Gly Lys           
            260                 265                 270                   

aag cat cgg atg cag cca gca tgc aac tgg act agg ggg gaa gtc ttg        864
Lys His Arg Met Gln Pro Ala Cys Asn Trp Thr Arg Gly Glu Val Leu           
        275                 280                 285                       

ggc ttg gag cac agg gat cgg gta gag cta tca ccc ctg ctc ctt acc        912
Gly Leu Glu His Arg Asp Arg Val Glu Leu Ser Pro Leu Leu Leu Thr           
    290                 295                 300                           

act aca gcg tgg cag atc ctc ccc tgc tct ttc acc act tta cca gcc        960
Thr Thr Ala Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala           
305                 310                 315                 320           

ctt tct acc ggc ttg atc cac ctc cac caa aat atc gtg gac gtc cag       1008
Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln           
                325                 330                 335               

tac ctc tac ggt gtt gga tct gca gtg gta tct tgg gcc ctc aaa tgg       1056
Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp           
            340                 345                 350                   

gaa tat gtg gtg ctc gtg ttc ctg ctt ctt gca gac gcg aga gtc tct       1104
Glu Tyr Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Val Ser           
        355                 360                 365                       

gct tgc cta tgg atg atg ttt atg gta tct cag                           1137
Ala Cys Leu Trp Met Met Phe Met Val Ser Gln                               
    370                 375                                               


<210>  8
<211>  379
<212>  PRT
<213>  Hepatitis C virus

<400>  8

Met Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly 
1               5                   10                  15      


Val Asp Ala Asn Thr His Thr Thr Gly Gly Ala Ala Gly Leu Gln Thr 
            20                  25                  30          


Arg Gly Phe Thr Gly Leu Phe Leu Pro Gly Ala Lys Gln Asn Leu Gln 
        35                  40                  45              


Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn 
    50                  55                  60                  


Cys Asn Asp Ser Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr 
65                  70                  75                  80  


Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg 
                85                  90                  95      


Ser Leu Asp Thr Phe Asn Gln Gly Trp Gly Pro Leu Gly Val Ala Asn 
            100                 105                 110         


Ile Ser Asp Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg 
        115                 120                 125             


Pro Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys 
    130                 135                 140                 


Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val 
145                 150                 155                 160 


Pro Thr Tyr Thr Trp Gly Glu Asn Glu Ser Asp Ala Phe Leu Leu Asn 
                165                 170                 175     


Ser Thr Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Val Trp Met Asn 
            180                 185                 190         


Ser Thr Gly Phe Thr Lys Ala Cys Gly Ala Pro Pro Cys Glu Val Thr 
        195                 200                 205             


Arg Ala Asn Asn Lys Thr Trp His Cys Pro Thr Asp Cys Phe Arg Lys 
    210                 215                 220                 


His Pro Glu Thr Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Ile Thr 
225                 230                 235                 240 


Pro Arg Cys Leu Ile Asp Tyr Arg Tyr Arg Leu Trp Gln Leu Pro Cys 
                245                 250                 255     


Thr Val Asn Ser Ser Val Phe Lys Val Arg Thr Tyr Met Ala Gly Lys 
            260                 265                 270         


Lys His Arg Met Gln Pro Ala Cys Asn Trp Thr Arg Gly Glu Val Leu 
        275                 280                 285             


Gly Leu Glu His Arg Asp Arg Val Glu Leu Ser Pro Leu Leu Leu Thr 
    290                 295                 300                 


Thr Thr Ala Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala 
305                 310                 315                 320 


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
                325                 330                 335     


Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp 
            340                 345                 350         


Glu Tyr Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Val Ser 
        355                 360                 365             


Ala Cys Leu Trp Met Met Phe Met Val Ser Gln 
    370                 375                 


<210>  9
<211>  1137
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(1137)
<223>  Protine E2 du virus HCV de gnotype 1a

<400>  9
atg ggg aac tgg gcg aag gtc ctg gtg gtg ctg ttg ctg ttc gcc agc         48
Met Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser           
1               5                   10                  15                

gtc gat gcg gaa acc tac acc acc ggg ggg agt att gcc aaa acc gtg         96
Val Asp Ala Glu Thr Tyr Thr Thr Gly Gly Ser Ile Ala Lys Thr Val           
            20                  25                  30                    

caa gga ttc acc agt ttt ttt acc cca ggc gcc aag cag gac atc cag        144
Gln Gly Phe Thr Ser Phe Phe Thr Pro Gly Ala Lys Gln Asp Ile Gln           
        35                  40                  45                        

ctg atc aac acc aac ggc agt tgg cac atc aat cgc acg gcc ttg aac        192
Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn           
    50                  55                  60                            

tgt aat gcg agc ctc gaa acc ggc tgg ata gcg ggg ctc ttc tac tac        240
Cys Asn Ala Ser Leu Glu Thr Gly Trp Ile Ala Gly Leu Phe Tyr Tyr           
65                  70                  75                  80            

aac aaa ttc aac tcc tca ggc tgc ccc gag agg atg gcc agc tgc aaa        288
Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys           
                85                  90                  95                

ccc ctt gcc tat ttc gcc caa ggc tgg ggc cct atc agc cat gtc aac        336
Pro Leu Ala Tyr Phe Ala Gln Gly Trp Gly Pro Ile Ser His Val Asn           
            100                 105                 110                   

gga agc ggc ccc gaa cag cgc ccc tac tgc tgg cac tac gcc cca agg        384
Gly Ser Gly Pro Glu Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg           
        115                 120                 125                       

cct tgt ggt atc gtg tca gca cag aca gta tgt ggc cca gtg tat tgt        432
Pro Cys Gly Ile Val Ser Ala Gln Thr Val Cys Gly Pro Val Tyr Cys           
    130                 135                 140                           

ttc act cct agc ccc gtg gtg gtg ggg acg acc gac aag ttg ggc gcg        480
Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Leu Gly Ala           
145                 150                 155                 160           

cct acc tac aac tgg ggt gag aat gat acg gac gtc ttc gtc ctc aat        528
Pro Thr Tyr Asn Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn           
                165                 170                 175               

aac acc agg cca ccg ttg ggc aat tgg ttc ggt tgc acc tgg atg aac        576
Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn           
            180                 185                 190                   

tca tct gga ttc acc aaa gtg tgc gga gcg cct ccc tgt gcc atc gga        624
Ser Ser Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly           
        195                 200                 205                       

gga gtg ggc aat aac acc ttg cgc tgt ccc act gac tgt ttc cgc aag        672
Gly Val Gly Asn Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys           
    210                 215                 220                           

cat ccg gaa gct aca tac tct cga tgt ggc tcc ggt ccc tgg atc acg        720
His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr           
225                 230                 235                 240           

ccc agg tgc ctg gtc gac tat cct tat agg ctc tgg cat tat cct tgc        768
Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys           
                245                 250                 255               

act gtc aac tac acc ctg ttt aaa atc agg atg tac gtg gga ggg gtc        816
Thr Val Asn Tyr Thr Leu Phe Lys Ile Arg Met Tyr Val Gly Gly Val           
            260                 265                 270                   

gag cac agg cta caa gct gct tgc aac tgg acg cgg ggc gag cgt tgt        864
Glu His Arg Leu Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys           
        275                 280                 285                       

gat ctg gac gac agg gac agg tcc gag ctc agc ccg ctg ctg ctg tcc        912
Asp Leu Asp Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser           
    290                 295                 300                           

acc acg cag tgg cag gtc ctt ccg tgt tct ttc acg acc ttg cca gcc        960
Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala           
305                 310                 315                 320           

ttg acc acc ggc ctc atc cac ctc cat cag aac atc gtg gac gtg caa       1008
Leu Thr Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln           
                325                 330                 335               

tat ttg tac ggg gtg ggg tca agc att gtg tcc tgg gcc atc aag tgg       1056
Tyr Leu Tyr Gly Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp           
            340                 345                 350                   

gag tac gtc att ctc ttg ttt ctc ctg ctt gca gac gcg cgc atc tgc       1104
Glu Tyr Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys           
        355                 360                 365                       

tcc tgc ttg tgg atg atg cta ctc ata tcc caa                           1137
Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln                               
    370                 375                                               


<210>  10
<211>  379
<212>  PRT
<213>  Hepatitis C virus

<400>  10

Met Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser 
1               5                   10                  15      


Val Asp Ala Glu Thr Tyr Thr Thr Gly Gly Ser Ile Ala Lys Thr Val 
            20                  25                  30          


Gln Gly Phe Thr Ser Phe Phe Thr Pro Gly Ala Lys Gln Asp Ile Gln 
        35                  40                  45              


Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn 
    50                  55                  60                  


Cys Asn Ala Ser Leu Glu Thr Gly Trp Ile Ala Gly Leu Phe Tyr Tyr 
65                  70                  75                  80  


Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys 
                85                  90                  95      


Pro Leu Ala Tyr Phe Ala Gln Gly Trp Gly Pro Ile Ser His Val Asn 
            100                 105                 110         


Gly Ser Gly Pro Glu Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg 
        115                 120                 125             


Pro Cys Gly Ile Val Ser Ala Gln Thr Val Cys Gly Pro Val Tyr Cys 
    130                 135                 140                 


Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Leu Gly Ala 
145                 150                 155                 160 


Pro Thr Tyr Asn Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn 
                165                 170                 175     


Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn 
            180                 185                 190         


Ser Ser Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly 
        195                 200                 205             


Gly Val Gly Asn Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys 
    210                 215                 220                 


His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr 
225                 230                 235                 240 


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
                245                 250                 255     


Thr Val Asn Tyr Thr Leu Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
            260                 265                 270         


Glu His Arg Leu Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
        275                 280                 285             


Asp Leu Asp Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser 
    290                 295                 300                 


Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala 
305                 310                 315                 320 


Leu Thr Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
                325                 330                 335     


Tyr Leu Tyr Gly Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp 
            340                 345                 350         


Glu Tyr Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
        355                 360                 365             


Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln 
    370                 375                 


<210>  11
<211>  1137
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(1137)
<223>  Protine E2 du virus HCV de gnotype 3a

<400>  11
atg ggc aat tgg gcc aag gtc gct gtc atc atg act atg ttt tca ggg         48
Met Gly Asn Trp Ala Lys Val Ala Val Ile Met Thr Met Phe Ser Gly           
1               5                   10                  15                

gtc gat gcc gca aca tac atc acc ggt ggc aca gta gct cat act act         96
Val Asp Ala Ala Thr Tyr Ile Thr Gly Gly Thr Val Ala His Thr Thr           
            20                  25                  30                    

aat agg ttc acc agc att ttc agt atg ggc gct caa cag aaa ttg cag        144
Asn Arg Phe Thr Ser Ile Phe Ser Met Gly Ala Gln Gln Lys Leu Gln           
        35                  40                  45                        

ctg gtc aac gcc aat ggc tcg tgg cac atc aac aga act gcc ctg aat        192
Leu Val Asn Ala Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn           
    50                  55                  60                            

tgt aat gag tcc ata aac acc ggg ttc ata gct ggg ttg ttt tac tat        240
Cys Asn Glu Ser Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr           
65                  70                  75                  80            

cat aag ttc aat tct act gga tgt cct caa agg ctc agc agc tgc aag        288
His Lys Phe Asn Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys           
                85                  90                  95                

ccc att act ttc ttt aag cag ggg tgg ggc ccc tta gga gat gct aac        336
Pro Ile Thr Phe Phe Lys Gln Gly Trp Gly Pro Leu Gly Asp Ala Asn           
            100                 105                 110                   

atc acc ggt cct gct gac aaa cca tac tgc tgg cac tac gca cct aga        384
Ile Thr Gly Pro Ala Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg           
        115                 120                 125                       

tct tgt gac gtt gtc tcg gca tta agt gtc tgc ggc cct gta tac tgc        432
Ser Cys Asp Val Val Ser Ala Leu Ser Val Cys Gly Pro Val Tyr Cys           
    130                 135                 140                           

ttc aca cca tcg cca gta gtc gta ggc act act gat gtt agg ggc gcg        480
Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Val Arg Gly Ala           
145                 150                 155                 160           

cca act tac aac tgg ggt gag aat gag aca gac gtg ttc ctg ctg aag        528
Pro Thr Tyr Asn Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Lys           
                165                 170                 175               

tcc ttg cgg cct ccc agt ggt cag tgg ttt ggg tgc gcg tgg atg aac        576
Ser Leu Arg Pro Pro Ser Gly Gln Trp Phe Gly Cys Ala Trp Met Asn           
            180                 185                 190                   

tcc tcg ggg ttt ctc aag acg tgc gga gct ccc cct tgt aac atc ggg        624
Ser Ser Gly Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly           
        195                 200                 205                       

gta gtg ggg agt cag acc tca tgc tgc ccc acc gac tgc ttc agg aag        672
Val Val Gly Ser Gln Thr Ser Cys Cys Pro Thr Asp Cys Phe Arg Lys           
    210                 215                 220                           

cac cct gag gct aca tac agc cgg tgt ggt gca ggg ccc tgg gtt aca        720
His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp Val Thr           
225                 230                 235                 240           

cct cga tgc atg gtc gac tac cca tac cgg ctc tgg cat tac cca tgt        768
Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys           
                245                 250                 255               

aca gtc aat ttc aca ttg ttc aag gtg agg atg ttc gtg ggt ggg ttc        816
Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly Gly Phe           
            260                 265                 270                   

gag cac cgg ttt acc gcc gct tgc aac tgg acc agg ggg gag cgc tgc        864
Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys           
        275                 280                 285                       

gat atc gaa gat cgt gac cgc agc gag caa cat cca ctg ttg cat tca        912
Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu His Ser           
    290                 295                 300                           

aca acc gag ctt gcc ata ctg cct tgc tct ttc acg ccc atg cct gca        960
Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met Pro Ala           
305                 310                 315                 320           

ctg tca aca ggt cta ata cac ctc cac caa aac atc gtg gat gtc caa       1008
Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln           
                325                 330                 335               

tac ctt tat ggc gtt gga tct ggc atg gtg gga tgg gcg ctg aaa tgg       1056
Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu Lys Trp           
            340                 345                 350                   

gag ttc gtc atc ctc att ttc ctc ctc cta gcg gac cga cgc gtg tgc       1104
Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Arg Arg Val Cys           
        355                 360                 365                       

gtt gcc ctt tgg ctg atg ctg atg ata tca caa                           1137
Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln                               
    370                 375                                               


<210>  12
<211>  379
<212>  PRT
<213>  Hepatitis C virus

<400>  12

Met Gly Asn Trp Ala Lys Val Ala Val Ile Met Thr Met Phe Ser Gly 
1               5                   10                  15      


Val Asp Ala Ala Thr Tyr Ile Thr Gly Gly Thr Val Ala His Thr Thr 
            20                  25                  30          


Asn Arg Phe Thr Ser Ile Phe Ser Met Gly Ala Gln Gln Lys Leu Gln 
        35                  40                  45              


Leu Val Asn Ala Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn 
    50                  55                  60                  


Cys Asn Glu Ser Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr 
65                  70                  75                  80  


His Lys Phe Asn Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys 
                85                  90                  95      


Pro Ile Thr Phe Phe Lys Gln Gly Trp Gly Pro Leu Gly Asp Ala Asn 
            100                 105                 110         


Ile Thr Gly Pro Ala Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg 
        115                 120                 125             


Ser Cys Asp Val Val Ser Ala Leu Ser Val Cys Gly Pro Val Tyr Cys 
    130                 135                 140                 


Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Val Arg Gly Ala 
145                 150                 155                 160 


Pro Thr Tyr Asn Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Lys 
                165                 170                 175     


Ser Leu Arg Pro Pro Ser Gly Gln Trp Phe Gly Cys Ala Trp Met Asn 
            180                 185                 190         


Ser Ser Gly Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly 
        195                 200                 205             


Val Val Gly Ser Gln Thr Ser Cys Cys Pro Thr Asp Cys Phe Arg Lys 
    210                 215                 220                 


His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp Val Thr 
225                 230                 235                 240 


Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
                245                 250                 255     


Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly Gly Phe 
            260                 265                 270         


Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
        275                 280                 285             


Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu His Ser 
    290                 295                 300                 


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met Pro Ala 
305                 310                 315                 320 


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
                325                 330                 335     


Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu Lys Trp 
            340                 345                 350         


Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Arg Arg Val Cys 
        355                 360                 365             


Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln 
    370                 375                 


<210>  13
<211>  648
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(648)
<223>  Protine E1 du virus HCV de gnotype 1a

<400>  13
atg aca ggg aac ctt cct ggt tgc tct ttc tct atc ttc ctt ctg gcc         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ctg ctc tct tgc ctg act gtg ccc gcg tca gcc tac caa gta cgc aac         96
Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr Gln Val Arg Asn           
            20                  25                  30                    

tcc tcg ggc ctt tac cat gtc acc aat gat tgc cct aac tcg agt att        144
Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro Asn Ser Ser Ile           
        35                  40                  45                        

gtg tac gag acg gcc gat acc atc cta cac tct ccg ggg tgt gtc cct        192
Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro Gly Cys Val Pro           
    50                  55                  60                            

tgc gtt cgc gag ggc aat gcc tca aaa tgt tgg gtg gcg gtg gcc cct        240
Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val Ala Val Ala Pro           
65                  70                  75                  80            

aca gtc gcc acc aga gac ggc aag ctc ccc aca acg cag ctt cga cgt        288
Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr Gln Leu Arg Arg           
                85                  90                  95                

cac atc gat ctg ctc gtc agg agc gcc acc ctc tgc tcg gcc ctc tat        336
His Ile Asp Leu Leu Val Arg Ser Ala Thr Leu Cys Ser Ala Leu Tyr           
            100                 105                 110                   

gtg ggg gac ttg tgc ggg tcc gtc ttc ctc gtc ggt caa ctg ttc acc        384
Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly Gln Leu Phe Thr           
        115                 120                 125                       

ttc tcc ccc agg cgc cac tgg aca acg caa gac tgc aac tgt tcc atg        432
Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Met           
    130                 135                 140                           

tac ccc ggc cat ata acg ggt cac cgt atg gca tgg gac atg atg atg        480
Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp Met Met Met           
145                 150                 155                 160           

aac tgg tcc cct acg aca gcg ctg gta gta gct cag ctg ctc agg gtc        528
Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln Leu Leu Arg Val           
                165                 170                 175               

ccg caa gcc atc ttg gac atg atc gct ggt gcc cac tgg gga gtc cta        576
Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His Trp Gly Val Leu           
            180                 185                 190                   

gcg ggc ata gcg tat ttc tcc atg gtg ggg aac tgg gcg aag gtc ctg        624
Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp Ala Lys Val Leu           
        195                 200                 205                       

gtg gtg ctg ttg ctg ttc gcc agc                                        648
Val Val Leu Leu Leu Phe Ala Ser                                           
    210                 215                                               


<210>  14
<211>  216
<212>  PRT
<213>  Hepatitis C virus

<400>  14

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr Gln Val Arg Asn 
            20                  25                  30          


Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro Asn Ser Ser Ile 
        35                  40                  45              


Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro Gly Cys Val Pro 
    50                  55                  60                  


Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val Ala Val Ala Pro 
65                  70                  75                  80  


Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr Gln Leu Arg Arg 
                85                  90                  95      


His Ile Asp Leu Leu Val Arg Ser Ala Thr Leu Cys Ser Ala Leu Tyr 
            100                 105                 110         


Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly Gln Leu Phe Thr 
        115                 120                 125             


Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Met 
    130                 135                 140                 


Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp Met Met Met 
145                 150                 155                 160 


Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln Leu Leu Arg Val 
                165                 170                 175     


Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His Trp Gly Val Leu 
            180                 185                 190         


Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp Ala Lys Val Leu 
        195                 200                 205             


Val Val Leu Leu Leu Phe Ala Ser 
    210                 215     


<210>  15
<211>  648
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(648)
<223>  Protine E1 du virus HCV de gnotype 3a

<400>  15
atg aca ggg aac ttg ccc ggt tgc tcc ttt tct atc ttc ctc ctc gct         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ttg ctc tct tgc tta atc cat cca gca gct agt cta gag tgg cgg aat         96
Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser Leu Glu Trp Arg Asn           
            20                  25                  30                    

gtg tct ggc ctc tat gtc ctc acc aac gac tgt ccc aat agc agt att        144
Val Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Pro Asn Ser Ser Ile           
        35                  40                  45                        

gtg tat gag gcc gat gac gtc att ctg cac aca ccc ggc tgt gta cct        192
Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro Gly Cys Val Pro           
    50                  55                  60                            

tgt gtt caa gat ggc aac ata tcc acg tgc tgg acc tca gta aca cct        240
Cys Val Gln Asp Gly Asn Ile Ser Thr Cys Trp Thr Ser Val Thr Pro           
65                  70                  75                  80            

aca gtg gca gtc agg tac ctc gga gca acc acc gct tcg gta cgc agt        288
Thr Val Ala Val Arg Tyr Leu Gly Ala Thr Thr Ala Ser Val Arg Ser           
                85                  90                  95                

cat gtg gac ttg tta gtg ggc gcg gcc acg atg tgc tct gcg ctc tac        336
His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr           
            100                 105                 110                   

gtg ggt gat atg tgt ggg gct gtc ttc ctt gtg ggg caa gcc ttc aca        384
Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly Gln Ala Phe Thr           
        115                 120                 125                       

ttc aga cct cgt cgc cat caa aca gtc cag acc tgt aac tgc tcg ctg        432
Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys Asn Cys Ser Leu           
    130                 135                 140                           

tat cca ggc cat ctt tca gga cac cga atg gct tgg gat atg atg atg        480
Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp Asp Met Met Met           
145                 150                 155                 160           

aat tgg tcc cct gct gtg ggc atg gtg gtg gcg cat gtc ctg cgg ttg        528
Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His Val Leu Arg Leu           
                165                 170                 175               

ccc cag acc ctg ttc gac ata ata gcc ggg gcc cat tgg ggc atc ttg        576
Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His Trp Gly Ile Leu           
            180                 185                 190                   

gcg ggc cta gcc tat tac tcc atg cag ggc aat tgg gcc aag gtc gct        624
Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp Ala Lys Val Ala           
        195                 200                 205                       

gtc atc atg att atg ttt tca ggg                                        648
Val Ile Met Ile Met Phe Ser Gly                                           
    210                 215                                               


<210>  16
<211>  216
<212>  PRT
<213>  Hepatitis C virus

<400>  16

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser Leu Glu Trp Arg Asn 
            20                  25                  30          


Val Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Pro Asn Ser Ser Ile 
        35                  40                  45              


Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro Gly Cys Val Pro 
    50                  55                  60                  


Cys Val Gln Asp Gly Asn Ile Ser Thr Cys Trp Thr Ser Val Thr Pro 
65                  70                  75                  80  


Thr Val Ala Val Arg Tyr Leu Gly Ala Thr Thr Ala Ser Val Arg Ser 
                85                  90                  95      


His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr 
            100                 105                 110         


Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly Gln Ala Phe Thr 
        115                 120                 125             


Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys Asn Cys Ser Leu 
    130                 135                 140                 


Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp Asp Met Met Met 
145                 150                 155                 160 


Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His Val Leu Arg Leu 
                165                 170                 175     


Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His Trp Gly Ile Leu 
            180                 185                 190         


Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp Ala Lys Val Ala 
        195                 200                 205             


Val Ile Met Ile Met Phe Ser Gly 
    210                 215     


<210>  17
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protine de fusion


<220>
<221>  CDS
<222>  (1)..(1266)
<223>  Protine fusion " E1 du virus HCV de gnotype 4a - Protine S 
       dlte du virus HBV de srotype adw "

<400>  17
atg aca ggg aat ctt cct ggt tgc tct ttt tct atc ttc ctt ttg gca         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ctt ctc tcg tgc ctg act gtc ccc gct tcg gcc gtt aac tac cgc aac         96
Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val Asn Tyr Arg Asn           
            20                  25                  30                    

acc tcg ggc atc tac cac atc acc aat gac tgc ccg aat tca agc ata        144
Thr Ser Gly Ile Tyr His Ile Thr Asn Asp Cys Pro Asn Ser Ser Ile           
        35                  40                  45                        

gtt tat gag gcc gac cat cac atc ttg cac ctt cca ggt tgc gtg ccc        192
Val Tyr Glu Ala Asp His His Ile Leu His Leu Pro Gly Cys Val Pro           
    50                  55                  60                            

tgc gtg aaa acg ggg aat cga tca cgt tgc tgg gtg gcc ctt act cct        240
Cys Val Lys Thr Gly Asn Arg Ser Arg Cys Trp Val Ala Leu Thr Pro           
65                  70                  75                  80            

act gtc gca gcg cca tac atc ggc gcg ccg ctt cac tct cta cgg agt        288
Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro Leu His Ser Leu Arg Ser           
                85                  90                  95                

cat gtg gat ctg atg gtg ggg gct gct acc gtt tgt tca gcc ctt tac        336
His Val Asp Leu Met Val Gly Ala Ala Thr Val Cys Ser Ala Leu Tyr           
            100                 105                 110                   

ata gga gat ttg tgt ggc ggc tta ttc ttg gct ggt cag gtg ttc tct        384
Ile Gly Asp Leu Cys Gly Gly Leu Phe Leu Ala Gly Gln Val Phe Ser           
        115                 120                 125                       

ttc cga cca cgg cgc cac tgg act acc cag gat tgc aat tgt tcc atc        432
Phe Arg Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Ile           
    130                 135                 140                           

tac aca ggg cac atc acc ggg cat aga atg gcc tgg ggc atg atg atg        480
Tyr Thr Gly His Ile Thr Gly His Arg Met Ala Trp Gly Met Met Met           
145                 150                 155                 160           

aac tgg agt cca aca act acc cta gtc ctt agc cag atc atg agg atc        528
Asn Trp Ser Pro Thr Thr Thr Leu Val Leu Ser Gln Ile Met Arg Ile           
                165                 170                 175               

cca ggt acc cta gta gac ttg ctc gct ggg ggc cac tgg ggt gtc ctt        576
Pro Gly Thr Leu Val Asp Leu Leu Ala Gly Gly His Trp Gly Val Leu           
            180                 185                 190                   

gtg gga gtg gct tat tac agc atg caa gct aat tgg gcc aaa gtc atc        624
Val Gly Val Ala Tyr Tyr Ser Met Gln Ala Asn Trp Ala Lys Val Ile           
        195                 200                 205                       

ttg gtc cta ttc ctc ttc gcg ggt aca aga atc ctc aca ata ccg cag        672
Leu Val Leu Phe Leu Phe Ala Gly Thr Arg Ile Leu Thr Ile Pro Gln           
    210                 215                 220                           

agt cta gac tcg tgg tgg act tct ctc aat ttt cta ggg gga tct ccc        720
Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro           
225                 230                 235                 240           

gtg tgt ctt ggc caa aat tcg cag tcc cca acc tcc aat cac tca cca        768
Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro           
                245                 250                 255               

acc tcc tgt cct cca att tgt cct ggt tat cgc tgg atg tgt ctg cgg        816
Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg           
            260                 265                 270                   

cgt ttt atc ata ttc ctc ttc atc ctg ctg cta tgc ctc atc ttc tta        864
Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu           
        275                 280                 285                       

ttg gtt ctt ctg gat tat caa ggt atg ttg ccc gtt tgt cct cta att        912
Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile           
    290                 295                 300                           

cca gga tca aca aca acc agt acg gga cca tgc aaa acc tgc acg act        960
Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr           
305                 310                 315                 320           

cct gct caa ggc aac tct atg ttt ccc tca tgt tgc tgt aca aaa cct       1008
Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro           
                325                 330                 335               

acg gat gga aat tgc acc tgt att ccc atc cca tcg tcc tgg gct ttc       1056
Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe           
            340                 345                 350                   

gca aaa tac cta tgg gag tgg gcc tca gtc cgt ttc tct tgg ctc agt       1104
Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser           
        355                 360                 365                       

tta cta gtg cca ttt gtt cag tgg ttc gta ggg ctt tcc ccc act gtt       1152
Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val           
    370                 375                 380                           

tgg ctt tca gct ata tgg atg atg tgg tat tgg ggg cca agt ctg tac       1200
Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr           
385                 390                 395                 400           

agc atc gtg agt ccc ttt ata ccg ctg tta cca att ttc ttt tgt ctc       1248
Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu           
                405                 410                 415               

tgg gta tac att taa taa                                               1266
Trp Val Tyr Ile                                                           
            420                                                           


<210>  18
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  18

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val Asn Tyr Arg Asn 
            20                  25                  30          


Thr Ser Gly Ile Tyr His Ile Thr Asn Asp Cys Pro Asn Ser Ser Ile 
        35                  40                  45              


Val Tyr Glu Ala Asp His His Ile Leu His Leu Pro Gly Cys Val Pro 
    50                  55                  60                  


Cys Val Lys Thr Gly Asn Arg Ser Arg Cys Trp Val Ala Leu Thr Pro 
65                  70                  75                  80  


Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro Leu His Ser Leu Arg Ser 
                85                  90                  95      


His Val Asp Leu Met Val Gly Ala Ala Thr Val Cys Ser Ala Leu Tyr 
            100                 105                 110         


Ile Gly Asp Leu Cys Gly Gly Leu Phe Leu Ala Gly Gln Val Phe Ser 
        115                 120                 125             


Phe Arg Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Ile 
    130                 135                 140                 


Tyr Thr Gly His Ile Thr Gly His Arg Met Ala Trp Gly Met Met Met 
145                 150                 155                 160 


Asn Trp Ser Pro Thr Thr Thr Leu Val Leu Ser Gln Ile Met Arg Ile 
                165                 170                 175     


Pro Gly Thr Leu Val Asp Leu Leu Ala Gly Gly His Trp Gly Val Leu 
            180                 185                 190         


Val Gly Val Ala Tyr Tyr Ser Met Gln Ala Asn Trp Ala Lys Val Ile 
        195                 200                 205             


Leu Val Leu Phe Leu Phe Ala Gly Thr Arg Ile Leu Thr Ile Pro Gln 
    210                 215                 220                 


Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro 
225                 230                 235                 240 


Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro 
                245                 250                 255     


Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg 
            260                 265                 270         


Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 
        275                 280                 285             


Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile 
    290                 295                 300                 


Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr 
305                 310                 315                 320 


Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro 
                325                 330                 335     


Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 
            340                 345                 350         


Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser 
        355                 360                 365             


Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 
    370                 375                 380                 


Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 
385                 390                 395                 400 


Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu 
                405                 410                 415     


Trp Val Tyr Ile 
            420 


<210>  19
<211>  1755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protine de fusion


<220>
<221>  CDS
<222>  (1)..(1755)
<223>  Protine fusion " E2 du virus HCV de gnotype 4a - Protine S 
       dlte du virus HBV de srotype adw "

<400>  19
atg gct aat tgg gcc aaa gtc atc ttg gtc cta ttc ctc ttc gca ggg         48
Met Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly           
1               5                   10                  15                

gtt gac gct aac acc cac acg act gga ggc gcg gcc ggc cta caa act         96
Val Asp Ala Asn Thr His Thr Thr Gly Gly Ala Ala Gly Leu Gln Thr           
            20                  25                  30                    

cgt ggt ttt act ggg ctc ttc ctc cct gga gct aaa caa aac ttg cag        144
Arg Gly Phe Thr Gly Leu Phe Leu Pro Gly Ala Lys Gln Asn Leu Gln           
        35                  40                  45                        

ctc att aac acc aat ggg agc tgg cat ata aac agg act gcc ctc aac        192
Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn           
    50                  55                  60                            

tgc aat gac agc tta aac act ggg ttc ttg gct agc ttg ttc tac acc        240
Cys Asn Asp Ser Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr           
65                  70                  75                  80            

aac aag ttt aac agt tca ggg tgt cct gaa cga ctt gca agc tgc aga        288
Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg           
                85                  90                  95                

agc ctt gat act ttc aac caa ggc tgg ggc cca ctt ggg gtc gct aac        336
Ser Leu Asp Thr Phe Asn Gln Gly Trp Gly Pro Leu Gly Val Ala Asn           
            100                 105                 110                   

atc agt gac tct gat gac agg cct tat tgc tgg cac tac ccc cct cga        384
Ile Ser Asp Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg           
        115                 120                 125                       

ccg tgc ggg att gtg ccg gca cgc agt gtg tgt ggc ccc gtg tat tgc        432
Pro Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys           
    130                 135                 140                           

ttt act ccc agc ccc gtc gtg gtc ggg aca act gat cgc ctt ggg gtc        480
Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val           
145                 150                 155                 160           

ccc acg tac acc tgg ggg gag aat gag tct gat gcc ttc ctg ttg aac        528
Pro Thr Tyr Thr Trp Gly Glu Asn Glu Ser Asp Ala Phe Leu Leu Asn           
                165                 170                 175               

tcg acc agg ccg cca caa ggt gcg tgg ttt gga tgc gtg tgg atg aac        576
Ser Thr Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Val Trp Met Asn           
            180                 185                 190                   

agc acc ggg ttt aca aaa gcc tgt gga gct cct cca tgc gag gtt acc        624
Ser Thr Gly Phe Thr Lys Ala Cys Gly Ala Pro Pro Cys Glu Val Thr           
        195                 200                 205                       

aga gcc aat aat aaa acc tgg cac tgc ccc act gat tgt ttc agg aag        672
Arg Ala Asn Asn Lys Thr Trp His Cys Pro Thr Asp Cys Phe Arg Lys           
    210                 215                 220                           

cat ccg gag acc acc tat gcc aaa tgc gga tca ggc ccc tgg atc aca        720
His Pro Glu Thr Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Ile Thr           
225                 230                 235                 240           

cca cga tgc ttg att gac tac cgg tat cgg ctg tgg caa tta cca tgc        768
Pro Arg Cys Leu Ile Asp Tyr Arg Tyr Arg Leu Trp Gln Leu Pro Cys           
                245                 250                 255               

acc gtc aac tct tct gtc ttt aaa gtc agg acc tat atg gcc ggt aag        816
Thr Val Asn Ser Ser Val Phe Lys Val Arg Thr Tyr Met Ala Gly Lys           
            260                 265                 270                   

aag cat cgg atg cag cca gca tgc aac tgg act agg ggg gaa gtc ttg        864
Lys His Arg Met Gln Pro Ala Cys Asn Trp Thr Arg Gly Glu Val Leu           
        275                 280                 285                       

ggc ttg gag cac agg gat cgg gta gag cta tca ccc ctg ctc ctt acc        912
Gly Leu Glu His Arg Asp Arg Val Glu Leu Ser Pro Leu Leu Leu Thr           
    290                 295                 300                           

act aca gcg tgg cag atc ctc ccc tgc tct ttc acc act tta cca gcc        960
Thr Thr Ala Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala           
305                 310                 315                 320           

ctt tct acc ggc ttg atc cac ctc cac caa aat atc gtg gac gtc cag       1008
Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln           
                325                 330                 335               

tac ctc tac ggt gtt gga tct gca gtg gta tct tgg gcc ctc aaa tgg       1056
Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp           
            340                 345                 350                   

gaa tat gtg gtg ctc gtg ttc ctg ctt ctt gca gac gcg aga gtc tct       1104
Glu Tyr Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Val Ser           
        355                 360                 365                       

gct tgc cta tgg atg atg ttt atg gta tct cag aca aga atc ctc aca       1152
Ala Cys Leu Trp Met Met Phe Met Val Ser Gln Thr Arg Ile Leu Thr           
    370                 375                 380                           

ata ccg cag agt cta gac tcg tgg tgg act tct ctc aat ttt cta ggg       1200
Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly           
385                 390                 395                 400           

gga tct ccc gtg tgt ctt ggc caa aat tcg cag tcc cca acc tcc aat       1248
Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn           
                405                 410                 415               

cac tca cca acc tcc tgt cct cca att tgt cct ggt tat cgc tgg atg       1296
His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met           
            420                 425                 430                   

tgt ctg cgg cgt ttt atc ata ttc ctc ttc atc ctg ctg cta tgc ctc       1344
Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu           
        435                 440                 445                       

atc ttc tta ttg gtt ctt ctg gat tat caa ggt atg ttg ccc gtt tgt       1392
Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys           
    450                 455                 460                           

cct cta att cca gga tca aca aca acc agt acg gga cca tgc aaa acc       1440
Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr           
465                 470                 475                 480           

tgc acg act cct gct caa ggc aac tct atg ttt ccc tca tgt tgc tgt       1488
Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys           
                485                 490                 495               

aca aaa cct acg gat gga aat tgc acc tgt att ccc atc cca tcg tcc       1536
Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser           
            500                 505                 510                   

tgg gct ttc gca aaa tac cta tgg gag tgg gcc tca gtc cgt ttc tct       1584
Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser           
        515                 520                 525                       

tgg ctc agt tta cta gtg cca ttt gtt cag tgg ttc gta ggg ctt tcc       1632
Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser           
    530                 535                 540                           

ccc act gtt tgg ctt tca gct ata tgg atg atg tgg tat tgg ggg cca       1680
Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro           
545                 550                 555                 560           

agt ctg tac agc atc gtg agt ccc ttt ata ccg ctg tta cca att ttc       1728
Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe           
                565                 570                 575               

ttt tgt ctc tgg gta tac att taa taa                                   1755
Phe Cys Leu Trp Val Tyr Ile                                               
            580                                                           


<210>  20
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  20

Met Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly 
1               5                   10                  15      


Val Asp Ala Asn Thr His Thr Thr Gly Gly Ala Ala Gly Leu Gln Thr 
            20                  25                  30          


Arg Gly Phe Thr Gly Leu Phe Leu Pro Gly Ala Lys Gln Asn Leu Gln 
        35                  40                  45              


Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn 
    50                  55                  60                  


Cys Asn Asp Ser Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr 
65                  70                  75                  80  


Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg 
                85                  90                  95      


Ser Leu Asp Thr Phe Asn Gln Gly Trp Gly Pro Leu Gly Val Ala Asn 
            100                 105                 110         


Ile Ser Asp Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Pro Pro Arg 
        115                 120                 125             


Pro Cys Gly Ile Val Pro Ala Arg Ser Val Cys Gly Pro Val Tyr Cys 
    130                 135                 140                 


Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg Leu Gly Val 
145                 150                 155                 160 


Pro Thr Tyr Thr Trp Gly Glu Asn Glu Ser Asp Ala Phe Leu Leu Asn 
                165                 170                 175     


Ser Thr Arg Pro Pro Gln Gly Ala Trp Phe Gly Cys Val Trp Met Asn 
            180                 185                 190         


Ser Thr Gly Phe Thr Lys Ala Cys Gly Ala Pro Pro Cys Glu Val Thr 
        195                 200                 205             


Arg Ala Asn Asn Lys Thr Trp His Cys Pro Thr Asp Cys Phe Arg Lys 
    210                 215                 220                 


His Pro Glu Thr Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Ile Thr 
225                 230                 235                 240 


Pro Arg Cys Leu Ile Asp Tyr Arg Tyr Arg Leu Trp Gln Leu Pro Cys 
                245                 250                 255     


Thr Val Asn Ser Ser Val Phe Lys Val Arg Thr Tyr Met Ala Gly Lys 
            260                 265                 270         


Lys His Arg Met Gln Pro Ala Cys Asn Trp Thr Arg Gly Glu Val Leu 
        275                 280                 285             


Gly Leu Glu His Arg Asp Arg Val Glu Leu Ser Pro Leu Leu Leu Thr 
    290                 295                 300                 


Thr Thr Ala Trp Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala 
305                 310                 315                 320 


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
                325                 330                 335     


Tyr Leu Tyr Gly Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp 
            340                 345                 350         


Glu Tyr Val Val Leu Val Phe Leu Leu Leu Ala Asp Ala Arg Val Ser 
        355                 360                 365             


Ala Cys Leu Trp Met Met Phe Met Val Ser Gln Thr Arg Ile Leu Thr 
    370                 375                 380                 


Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 
385                 390                 395                 400 


Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn 
                405                 410                 415     


His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met 
            420                 425                 430         


Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 
        435                 440                 445             


Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 
    450                 455                 460                 


Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr 
465                 470                 475                 480 


Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys 
                485                 490                 495     


Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser 
            500                 505                 510         


Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser 
        515                 520                 525             


Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser 
    530                 535                 540                 


Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro 
545                 550                 555                 560 


Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe 
                565                 570                 575     


Phe Cys Leu Trp Val Tyr Ile 
            580             


<210>  21
<211>  1755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protine de fusion


<220>
<221>  CDS
<222>  (1)..(1755)
<223>  Protine fusion " E2 du virus HCV de gnotype 1a - Protine S 
       dlte du virus HBV de srotype adw "

<400>  21
atg ggg aac tgg gcg aag gtc ctg gtg gtg ctg ttg ctg ttc gcc agc         48
Met Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser           
1               5                   10                  15                

gtc gat gcg gaa acc tac acc acc ggg ggg agt att gcc aaa acc gtg         96
Val Asp Ala Glu Thr Tyr Thr Thr Gly Gly Ser Ile Ala Lys Thr Val           
            20                  25                  30                    

caa gga ttc acc agt ttt ttt acc cca ggc gcc aag cag gac atc cag        144
Gln Gly Phe Thr Ser Phe Phe Thr Pro Gly Ala Lys Gln Asp Ile Gln           
        35                  40                  45                        

ctg atc aac acc aac ggc agt tgg cac atc aat cgc acg gcc ttg aac        192
Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn           
    50                  55                  60                            

tgt aat gcg agc ctc gaa acc ggc tgg ata gcg ggg ctc ttc tac tac        240
Cys Asn Ala Ser Leu Glu Thr Gly Trp Ile Ala Gly Leu Phe Tyr Tyr           
65                  70                  75                  80            

aac aaa ttc aac tcc tca ggc tgc ccc gag agg atg gcc agc tgc aaa        288
Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys           
                85                  90                  95                

ccc ctt gcc tat ttc gcc caa ggc tgg ggc cct atc agc cat gtc aac        336
Pro Leu Ala Tyr Phe Ala Gln Gly Trp Gly Pro Ile Ser His Val Asn           
            100                 105                 110                   

gga agc ggc ccc gaa cag cgc ccc tac tgc tgg cac tac gcc cca agg        384
Gly Ser Gly Pro Glu Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg           
        115                 120                 125                       

cct tgt ggt atc gtg tca gca cag aca gta tgt ggc cca gtg tat tgt        432
Pro Cys Gly Ile Val Ser Ala Gln Thr Val Cys Gly Pro Val Tyr Cys           
    130                 135                 140                           

ttc act cct agc ccc gtg gtg gtg ggg acg acc gac aag ttg ggc gcg        480
Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Leu Gly Ala           
145                 150                 155                 160           

cct acc tac aac tgg ggt gag aat gat acg gac gtc ttc gtc ctc aat        528
Pro Thr Tyr Asn Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn           
                165                 170                 175               

aac acc agg cca ccg ttg ggc aat tgg ttc ggt tgc acc tgg atg aac        576
Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn           
            180                 185                 190                   

tca tct gga ttc acc aaa gtg tgc gga gcg cct ccc tgt gcc atc gga        624
Ser Ser Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly           
        195                 200                 205                       

gga gtg ggc aat aac acc ttg cgc tgt ccc act gac tgt ttc cgc aag        672
Gly Val Gly Asn Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys           
    210                 215                 220                           

cat ccg gaa gct aca tac tct cga tgt ggc tcc ggt ccc tgg atc acg        720
His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr           
225                 230                 235                 240           

ccc agg tgc ctg gtc gac tat cct tat agg ctc tgg cat tat cct tgc        768
Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys           
                245                 250                 255               

act gtc aac tac acc ctg ttt aaa atc agg atg tac gtg gga ggg gtc        816
Thr Val Asn Tyr Thr Leu Phe Lys Ile Arg Met Tyr Val Gly Gly Val           
            260                 265                 270                   

gag cac agg cta caa gct gct tgc aac tgg acg cgg ggc gag cgt tgt        864
Glu His Arg Leu Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys           
        275                 280                 285                       

gat ctg gac gac agg gac agg tcc gag ctc agc ccg ctg ctg ctg tcc        912
Asp Leu Asp Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser           
    290                 295                 300                           

acc acg cag tgg cag gtc ctt ccg tgt tct ttc acg acc ttg cca gcc        960
Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala           
305                 310                 315                 320           

ttg acc acc ggc ctc atc cac ctc cat cag aac atc gtg gac gtg caa       1008
Leu Thr Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln           
                325                 330                 335               

tat ttg tac ggg gtg ggg tca agc att gtg tcc tgg gcc atc aag tgg       1056
Tyr Leu Tyr Gly Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp           
            340                 345                 350                   

gag tac gtc att ctc ttg ttt ctc ctg ctt gca gac gcg cgc atc tgc       1104
Glu Tyr Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys           
        355                 360                 365                       

tcc tgc ttg tgg atg atg cta ctc ata tcc caa aca aga atc ctc aca       1152
Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln Thr Arg Ile Leu Thr           
    370                 375                 380                           

ata ccg cag agt cta gac tcg tgg tgg act tct ctc aat ttt cta ggg       1200
Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly           
385                 390                 395                 400           

gga tct ccc gtg tgt ctt ggc caa aat tcg cag tcc cca acc tcc aat       1248
Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn           
                405                 410                 415               

cac tca cca acc tcc tgt cct cca att tgt cct ggt tat cgc tgg atg       1296
His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met           
            420                 425                 430                   

tgt ctg cgg cgt ttt atc ata ttc ctc ttc atc ctg ctg cta tgc ctc       1344
Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu           
        435                 440                 445                       

atc ttc tta ttg gtt ctt ctg gat tat caa ggt atg ttg ccc gtt tgt       1392
Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys           
    450                 455                 460                           

cct cta att cca gga tca aca aca acc agt acg gga cca tgc aaa acc       1440
Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr           
465                 470                 475                 480           

tgc acg act cct gct caa ggc aac tct atg ttt ccc tca tgt tgc tgt       1488
Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys           
                485                 490                 495               

aca aaa cct acg gat gga aat tgc acc tgt att ccc atc cca tcg tcc       1536
Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser           
            500                 505                 510                   

tgg gct ttc gca aaa tac cta tgg gag tgg gcc tca gtc cgt ttc tct       1584
Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser           
        515                 520                 525                       

tgg ctc agt tta cta gtg cca ttt gtt cag tgg ttc gta ggg ctt tcc       1632
Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser           
    530                 535                 540                           

ccc act gtt tgg ctt tca gct ata tgg atg atg tgg tat tgg ggg cca       1680
Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro           
545                 550                 555                 560           

agt ctg tac agc atc gtg agt ccc ttt ata ccg ctg tta cca att ttc       1728
Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe           
                565                 570                 575               

ttt tgt ctc tgg gta tac att taa taa                                   1755
Phe Cys Leu Trp Val Tyr Ile                                               
            580                                                           


<210>  22
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  22

Met Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser 
1               5                   10                  15      


Val Asp Ala Glu Thr Tyr Thr Thr Gly Gly Ser Ile Ala Lys Thr Val 
            20                  25                  30          


Gln Gly Phe Thr Ser Phe Phe Thr Pro Gly Ala Lys Gln Asp Ile Gln 
        35                  40                  45              


Leu Ile Asn Thr Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn 
    50                  55                  60                  


Cys Asn Ala Ser Leu Glu Thr Gly Trp Ile Ala Gly Leu Phe Tyr Tyr 
65                  70                  75                  80  


Asn Lys Phe Asn Ser Ser Gly Cys Pro Glu Arg Met Ala Ser Cys Lys 
                85                  90                  95      


Pro Leu Ala Tyr Phe Ala Gln Gly Trp Gly Pro Ile Ser His Val Asn 
            100                 105                 110         


Gly Ser Gly Pro Glu Gln Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg 
        115                 120                 125             


Pro Cys Gly Ile Val Ser Ala Gln Thr Val Cys Gly Pro Val Tyr Cys 
    130                 135                 140                 


Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Lys Leu Gly Ala 
145                 150                 155                 160 


Pro Thr Tyr Asn Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn 
                165                 170                 175     


Asn Thr Arg Pro Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn 
            180                 185                 190         


Ser Ser Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Cys Ala Ile Gly 
        195                 200                 205             


Gly Val Gly Asn Asn Thr Leu Arg Cys Pro Thr Asp Cys Phe Arg Lys 
    210                 215                 220                 


His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr 
225                 230                 235                 240 


Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
                245                 250                 255     


Thr Val Asn Tyr Thr Leu Phe Lys Ile Arg Met Tyr Val Gly Gly Val 
            260                 265                 270         


Glu His Arg Leu Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
        275                 280                 285             


Asp Leu Asp Asp Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser 
    290                 295                 300                 


Thr Thr Gln Trp Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala 
305                 310                 315                 320 


Leu Thr Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
                325                 330                 335     


Tyr Leu Tyr Gly Val Gly Ser Ser Ile Val Ser Trp Ala Ile Lys Trp 
            340                 345                 350         


Glu Tyr Val Ile Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Ile Cys 
        355                 360                 365             


Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln Thr Arg Ile Leu Thr 
    370                 375                 380                 


Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 
385                 390                 395                 400 


Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn 
                405                 410                 415     


His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met 
            420                 425                 430         


Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 
        435                 440                 445             


Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 
    450                 455                 460                 


Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr 
465                 470                 475                 480 


Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys 
                485                 490                 495     


Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser 
            500                 505                 510         


Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser 
        515                 520                 525             


Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser 
    530                 535                 540                 


Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro 
545                 550                 555                 560 


Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe 
                565                 570                 575     


Phe Cys Leu Trp Val Tyr Ile 
            580             


<210>  23
<211>  1755
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protine de fusion


<220>
<221>  CDS
<222>  (1)..(1755)
<223>  Protine fusion " E2 du virus HCV de gnotype 3a - Protine S 
       dlte du virus HBV de srotype adw "

<400>  23
atg ggc aat tgg gcc aag gtc gct gtc atc atg act atg ttt tca ggg         48
Met Gly Asn Trp Ala Lys Val Ala Val Ile Met Thr Met Phe Ser Gly           
1               5                   10                  15                

gtc gat gcc gca aca tac atc acc ggt ggc aca gta gct cat act act         96
Val Asp Ala Ala Thr Tyr Ile Thr Gly Gly Thr Val Ala His Thr Thr           
            20                  25                  30                    

aat agg ttc acc agc att ttc agt atg ggc gct caa cag aaa ttg cag        144
Asn Arg Phe Thr Ser Ile Phe Ser Met Gly Ala Gln Gln Lys Leu Gln           
        35                  40                  45                        

ctg gtc aac gcc aat ggc tcg tgg cac atc aac aga act gcc ctg aat        192
Leu Val Asn Ala Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn           
    50                  55                  60                            

tgt aat gag tcc ata aac acc ggg ttc ata gct ggg ttg ttt tac tat        240
Cys Asn Glu Ser Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr           
65                  70                  75                  80            

cat aag ttc aat tct act gga tgt cct caa agg ctc agc agc tgc aag        288
His Lys Phe Asn Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys           
                85                  90                  95                

ccc att act ttc ttt aag cag ggg tgg ggc ccc tta gga gat gct aac        336
Pro Ile Thr Phe Phe Lys Gln Gly Trp Gly Pro Leu Gly Asp Ala Asn           
            100                 105                 110                   

atc acc ggt cct gct gac aaa cca tac tgc tgg cac tac gca cct aga        384
Ile Thr Gly Pro Ala Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg           
        115                 120                 125                       

tct tgt gac gtt gtc tcg gca tta agt gtc tgc ggc cct gta tac tgc        432
Ser Cys Asp Val Val Ser Ala Leu Ser Val Cys Gly Pro Val Tyr Cys           
    130                 135                 140                           

ttc aca cca tcg cca gta gtc gta ggc act act gat gtt agg ggc gcg        480
Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Val Arg Gly Ala           
145                 150                 155                 160           

cca act tac aac tgg ggt gag aat gag aca gac gtg ttc ctg ctg aag        528
Pro Thr Tyr Asn Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Lys           
                165                 170                 175               

tcc ttg cgg cct ccc agt ggt cag tgg ttt ggg tgc gcg tgg atg aac        576
Ser Leu Arg Pro Pro Ser Gly Gln Trp Phe Gly Cys Ala Trp Met Asn           
            180                 185                 190                   

tcc tcg ggg ttt ctc aag acg tgc gga gct ccc cct tgt aac atc ggg        624
Ser Ser Gly Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly           
        195                 200                 205                       

gta gtg ggg agt cag acc tca tgc tgc ccc acc gac tgc ttc agg aag        672
Val Val Gly Ser Gln Thr Ser Cys Cys Pro Thr Asp Cys Phe Arg Lys           
    210                 215                 220                           

cac cct gag gct aca tac agc cgg tgt ggt gca ggg ccc tgg gtt aca        720
His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp Val Thr           
225                 230                 235                 240           

cct cga tgc atg gtc gac tac cca tac cgg ctc tgg cat tac cca tgt        768
Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys           
                245                 250                 255               

aca gtc aat ttc aca ttg ttc aag gtg agg atg ttc gtg ggt ggg ttc        816
Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly Gly Phe           
            260                 265                 270                   

gag cac cgg ttt acc gcc gct tgc aac tgg acc agg ggg gag cgc tgc        864
Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys           
        275                 280                 285                       

gat atc gaa gat cgt gac cgc agc gag caa cat cca ctg ttg cat tca        912
Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu His Ser           
    290                 295                 300                           

aca acc gag ctt gcc ata ctg cct tgc tct ttc acg ccc atg cct gca        960
Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met Pro Ala           
305                 310                 315                 320           

ctg tca aca ggt cta ata cac ctc cac caa aac atc gtg gat gtc caa       1008
Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln           
                325                 330                 335               

tac ctt tat ggc gtt gga tct ggc atg gtg gga tgg gcg ctg aaa tgg       1056
Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu Lys Trp           
            340                 345                 350                   

gag ttc gtc atc ctc att ttc ctc ctc cta gcg gac cga cgc gtg tgc       1104
Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Arg Arg Val Cys           
        355                 360                 365                       

gtt gcc ctt tgg ctg atg ctg atg ata tca caa aca aga atc ctc aca       1152
Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Thr Arg Ile Leu Thr           
    370                 375                 380                           

ata ccg cag agt cta gac tcg tgg tgg act tct ctc aat ttt cta ggg       1200
Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly           
385                 390                 395                 400           

gga tct ccc gtg tgt ctt ggc caa aat tcg cag tcc cca acc tcc aat       1248
Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn           
                405                 410                 415               

cac tca cca acc tcc tgt cct cca att tgt cct ggt tat cgc tgg atg       1296
His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met           
            420                 425                 430                   

tgt ctg cgg cgt ttt atc ata ttc ctc ttc atc ctg ctg cta tgc ctc       1344
Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu           
        435                 440                 445                       

atc ttc tta ttg gtt ctt ctg gat tat caa ggt atg ttg ccc gtt tgt       1392
Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys           
    450                 455                 460                           

cct cta att cca gga tca aca aca acc agt acg gga cca tgc aaa acc       1440
Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr           
465                 470                 475                 480           

tgc acg act cct gct caa ggc aac tct atg ttt ccc tca tgt tgc tgt       1488
Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys           
                485                 490                 495               

aca aaa cct acg gat gga aat tgc acc tgt att ccc atc cca tcg tcc       1536
Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser           
            500                 505                 510                   

tgg gct ttc gca aaa tac cta tgg gag tgg gcc tca gtc cgt ttc tct       1584
Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser           
        515                 520                 525                       

tgg ctc agt tta cta gtg cca ttt gtt cag tgg ttc gta ggg ctt tcc       1632
Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser           
    530                 535                 540                           

ccc act gtt tgg ctt tca gct ata tgg atg atg tgg tat tgg ggg cca       1680
Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro           
545                 550                 555                 560           

agt ctg tac agc atc gtg agt ccc ttt ata ccg ctg tta cca att ttc       1728
Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe           
                565                 570                 575               

ttt tgt ctc tgg gta tac att taa taa                                   1755
Phe Cys Leu Trp Val Tyr Ile                                               
            580                                                           


<210>  24
<211>  583
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  24

Met Gly Asn Trp Ala Lys Val Ala Val Ile Met Thr Met Phe Ser Gly 
1               5                   10                  15      


Val Asp Ala Ala Thr Tyr Ile Thr Gly Gly Thr Val Ala His Thr Thr 
            20                  25                  30          


Asn Arg Phe Thr Ser Ile Phe Ser Met Gly Ala Gln Gln Lys Leu Gln 
        35                  40                  45              


Leu Val Asn Ala Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn 
    50                  55                  60                  


Cys Asn Glu Ser Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr 
65                  70                  75                  80  


His Lys Phe Asn Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys 
                85                  90                  95      


Pro Ile Thr Phe Phe Lys Gln Gly Trp Gly Pro Leu Gly Asp Ala Asn 
            100                 105                 110         


Ile Thr Gly Pro Ala Asp Lys Pro Tyr Cys Trp His Tyr Ala Pro Arg 
        115                 120                 125             


Ser Cys Asp Val Val Ser Ala Leu Ser Val Cys Gly Pro Val Tyr Cys 
    130                 135                 140                 


Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp Val Arg Gly Ala 
145                 150                 155                 160 


Pro Thr Tyr Asn Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Lys 
                165                 170                 175     


Ser Leu Arg Pro Pro Ser Gly Gln Trp Phe Gly Cys Ala Trp Met Asn 
            180                 185                 190         


Ser Ser Gly Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Gly 
        195                 200                 205             


Val Val Gly Ser Gln Thr Ser Cys Cys Pro Thr Asp Cys Phe Arg Lys 
    210                 215                 220                 


His Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp Val Thr 
225                 230                 235                 240 


Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys 
                245                 250                 255     


Thr Val Asn Phe Thr Leu Phe Lys Val Arg Met Phe Val Gly Gly Phe 
            260                 265                 270         


Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys 
        275                 280                 285             


Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu His Ser 
    290                 295                 300                 


Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met Pro Ala 
305                 310                 315                 320 


Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln 
                325                 330                 335     


Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu Lys Trp 
            340                 345                 350         


Glu Phe Val Ile Leu Ile Phe Leu Leu Leu Ala Asp Arg Arg Val Cys 
        355                 360                 365             


Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Thr Arg Ile Leu Thr 
    370                 375                 380                 


Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly 
385                 390                 395                 400 


Gly Ser Pro Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn 
                405                 410                 415     


His Ser Pro Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met 
            420                 425                 430         


Cys Leu Arg Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu 
        435                 440                 445             


Ile Phe Leu Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys 
    450                 455                 460                 


Pro Leu Ile Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr 
465                 470                 475                 480 


Cys Thr Thr Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys 
                485                 490                 495     


Thr Lys Pro Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser 
            500                 505                 510         


Trp Ala Phe Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser 
        515                 520                 525             


Trp Leu Ser Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser 
    530                 535                 540                 


Pro Thr Val Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro 
545                 550                 555                 560 


Ser Leu Tyr Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe 
                565                 570                 575     


Phe Cys Leu Trp Val Tyr Ile 
            580             


<210>  25
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protine de fusion


<220>
<221>  CDS
<222>  (1)..(1266)
<223>  Protine fusion " E1 du virus HCV de gnotype 1a - Protine S 
       dlte du virus HBV de srotype adw "

<400>  25
atg aca ggg aac ctt cct ggt tgc tct ttc tct atc ttc ctt ctg gcc         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ctg ctc tct tgc ctg act gtg ccc gcg tca gcc tac caa gta cgc aac         96
Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr Gln Val Arg Asn           
            20                  25                  30                    

tcc tcg ggc ctt tac cat gtc acc aat gat tgc cct aac tcg agt att        144
Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro Asn Ser Ser Ile           
        35                  40                  45                        

gtg tac gag acg gcc gat acc atc cta cac tct ccg ggg tgt gtc cct        192
Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro Gly Cys Val Pro           
    50                  55                  60                            

tgc gtt cgc gag ggc aat gcc tca aaa tgt tgg gtg gcg gtg gcc cct        240
Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val Ala Val Ala Pro           
65                  70                  75                  80            

aca gtc gcc acc aga gac ggc aag ctc ccc aca acg cag ctt cga cgt        288
Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr Gln Leu Arg Arg           
                85                  90                  95                

cac atc gat ctg ctc gtc agg agc gcc acc ctc tgc tcg gcc ctc tat        336
His Ile Asp Leu Leu Val Arg Ser Ala Thr Leu Cys Ser Ala Leu Tyr           
            100                 105                 110                   

gtg ggg gac ttg tgc ggg tcc gtc ttc ctc gtc ggt caa ctg ttc acc        384
Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly Gln Leu Phe Thr           
        115                 120                 125                       

ttc tcc ccc agg cgc cac tgg aca acg caa gac tgc aac tgt tcc atg        432
Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Met           
    130                 135                 140                           

tac ccc ggc cat ata acg ggt cac cgt atg gca tgg gac atg atg atg        480
Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp Met Met Met           
145                 150                 155                 160           

aac tgg tcc cct acg aca gcg ctg gta gta gct cag ctg ctc agg gtc        528
Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln Leu Leu Arg Val           
                165                 170                 175               

ccg caa gcc atc ttg gac atg atc gct ggt gcc cac tgg gga gtc cta        576
Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His Trp Gly Val Leu           
            180                 185                 190                   

gcg ggc ata gcg tat ttc tcc atg gtg ggg aac tgg gcg aag gtc ctg        624
Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp Ala Lys Val Leu           
        195                 200                 205                       

gtg gtg ctg ttg ctg ttc gcc agc aca aga atc ctc aca ata ccg cag        672
Val Val Leu Leu Leu Phe Ala Ser Thr Arg Ile Leu Thr Ile Pro Gln           
    210                 215                 220                           

agt cta gac tcg tgg tgg act tct ctc aat ttt cta ggg gga tct ccc        720
Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro           
225                 230                 235                 240           

gtg tgt ctt ggc caa aat tcg cag tcc cca acc tcc aat cac tca cca        768
Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro           
                245                 250                 255               

acc tcc tgt cct cca att tgt cct ggt tat cgc tgg atg tgt ctg cgg        816
Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg           
            260                 265                 270                   

cgt ttt atc ata ttc ctc ttc atc ctg ctg cta tgc ctc atc ttc tta        864
Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu           
        275                 280                 285                       

ttg gtt ctt ctg gat tat caa ggt atg ttg ccc gtt tgt cct cta att        912
Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile           
    290                 295                 300                           

cca gga tca aca aca acc agt acg gga cca tgc aaa acc tgc acg act        960
Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr           
305                 310                 315                 320           

cct gct caa ggc aac tct atg ttt ccc tca tgt tgc tgt aca aaa cct       1008
Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro           
                325                 330                 335               

acg gat gga aat tgc acc tgt att ccc atc cca tcg tcc tgg gct ttc       1056
Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe           
            340                 345                 350                   

gca aaa tac cta tgg gag tgg gcc tca gtc cgt ttc tct tgg ctc agt       1104
Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser           
        355                 360                 365                       

tta cta gtg cca ttt gtt cag tgg ttc gta ggg ctt tcc ccc act gtt       1152
Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val           
    370                 375                 380                           

tgg ctt tca gct ata tgg atg atg tgg tat tgg ggg cca agt ctg tac       1200
Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr           
385                 390                 395                 400           

agc atc gtg agt ccc ttt ata ccg ctg tta cca att ttc ttt tgt ctc       1248
Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu           
                405                 410                 415               

tgg gta tac att taa taa                                               1266
Trp Val Tyr Ile                                                           
            420                                                           


<210>  26
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  26

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr Gln Val Arg Asn 
            20                  25                  30          


Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro Asn Ser Ser Ile 
        35                  40                  45              


Val Tyr Glu Thr Ala Asp Thr Ile Leu His Ser Pro Gly Cys Val Pro 
    50                  55                  60                  


Cys Val Arg Glu Gly Asn Ala Ser Lys Cys Trp Val Ala Val Ala Pro 
65                  70                  75                  80  


Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr Gln Leu Arg Arg 
                85                  90                  95      


His Ile Asp Leu Leu Val Arg Ser Ala Thr Leu Cys Ser Ala Leu Tyr 
            100                 105                 110         


Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly Gln Leu Phe Thr 
        115                 120                 125             


Phe Ser Pro Arg Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Met 
    130                 135                 140                 


Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp Asp Met Met Met 
145                 150                 155                 160 


Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ala Gln Leu Leu Arg Val 
                165                 170                 175     


Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His Trp Gly Val Leu 
            180                 185                 190         


Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp Ala Lys Val Leu 
        195                 200                 205             


Val Val Leu Leu Leu Phe Ala Ser Thr Arg Ile Leu Thr Ile Pro Gln 
    210                 215                 220                 


Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro 
225                 230                 235                 240 


Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro 
                245                 250                 255     


Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg 
            260                 265                 270         


Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 
        275                 280                 285             


Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile 
    290                 295                 300                 


Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr 
305                 310                 315                 320 


Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro 
                325                 330                 335     


Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 
            340                 345                 350         


Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser 
        355                 360                 365             


Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 
    370                 375                 380                 


Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 
385                 390                 395                 400 


Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu 
                405                 410                 415     


Trp Val Tyr Ile 
            420 


<210>  27
<211>  1266
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Protine de fusion


<220>
<221>  CDS
<222>  (1)..(1266)
<223>  Protine fusion " E1 du virus HCV de gnotype 3a - Protine S 
       dlte du virus HBV de srotype adw "

<400>  27
atg aca ggg aac ttg ccc ggt tgc tcc ttt tct atc ttc ctc ctc gct         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ttg ctc tct tgc tta atc cat cca gca gct agt cta gag tgg cgg aat         96
Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser Leu Glu Trp Arg Asn           
            20                  25                  30                    

gtg tct ggc ctc tat gtc ctc acc aac gac tgt ccc aat agc agt att        144
Val Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Pro Asn Ser Ser Ile           
        35                  40                  45                        

gtg tat gag gcc gat gac gtc att ctg cac aca ccc ggc tgt gta cct        192
Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro Gly Cys Val Pro           
    50                  55                  60                            

tgt gtt caa gat ggc aac ata tcc acg tgc tgg acc tca gta aca cct        240
Cys Val Gln Asp Gly Asn Ile Ser Thr Cys Trp Thr Ser Val Thr Pro           
65                  70                  75                  80            

aca gtg gca gtc agg tac ctc gga gca acc acc gct tcg gta cgc agt        288
Thr Val Ala Val Arg Tyr Leu Gly Ala Thr Thr Ala Ser Val Arg Ser           
                85                  90                  95                

cat gtg gac ttg tta gtg ggc gcg gcc acg atg tgc tct gcg ctc tac        336
His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr           
            100                 105                 110                   

gtg ggt gat atg tgt ggg gct gtc ttc ctt gtg ggg caa gcc ttc aca        384
Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly Gln Ala Phe Thr           
        115                 120                 125                       

ttc aga cct cgt cgc cat caa aca gtc cag acc tgt aac tgc tcg ctg        432
Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys Asn Cys Ser Leu           
    130                 135                 140                           

tat cca ggc cat ctt tca gga cac cga atg gct tgg gat atg atg atg        480
Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp Asp Met Met Met           
145                 150                 155                 160           

aat tgg tcc cct gct gtg ggc atg gtg gtg gcg cat gtc ctg cgg ttg        528
Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His Val Leu Arg Leu           
                165                 170                 175               

ccc cag acc ctg ttc gac ata ata gcc ggg gcc cat tgg ggc atc ttg        576
Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His Trp Gly Ile Leu           
            180                 185                 190                   

gcg ggc cta gcc tat tac tcc atg cag ggc aat tgg gcc aag gtc gct        624
Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp Ala Lys Val Ala           
        195                 200                 205                       

gtc atc atg att atg ttt tca ggg aca aga atc ctc aca ata ccg cag        672
Val Ile Met Ile Met Phe Ser Gly Thr Arg Ile Leu Thr Ile Pro Gln           
    210                 215                 220                           

agt cta gac tcg tgg tgg act tct ctc aat ttt cta ggg gga tct ccc        720
Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro           
225                 230                 235                 240           

gtg tgt ctt ggc caa aat tcg cag tcc cca acc tcc aat cac tca cca        768
Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro           
                245                 250                 255               

acc tcc tgt cct cca att tgt cct ggt tat cgc tgg atg tgt ctg cgg        816
Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg           
            260                 265                 270                   

cgt ttt atc ata ttc ctc ttc atc ctg ctg cta tgc ctc atc ttc tta        864
Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu           
        275                 280                 285                       

ttg gtt ctt ctg gat tat caa ggt atg ttg ccc gtt tgt cct cta att        912
Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile           
    290                 295                 300                           

cca gga tca aca aca acc agt acg gga cca tgc aaa acc tgc acg act        960
Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr           
305                 310                 315                 320           

cct gct caa ggc aac tct atg ttt ccc tca tgt tgc tgt aca aaa cct       1008
Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro           
                325                 330                 335               

acg gat gga aat tgc acc tgt att ccc atc cca tcg tcc tgg gct ttc       1056
Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe           
            340                 345                 350                   

gca aaa tac cta tgg gag tgg gcc tca gtc cgt ttc tct tgg ctc agt       1104
Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser           
        355                 360                 365                       

tta cta gtg cca ttt gtt cag tgg ttc gta ggg ctt tcc ccc act gtt       1152
Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val           
    370                 375                 380                           

tgg ctt tca gct ata tgg atg atg tgg tat tgg ggg cca agt ctg tac       1200
Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr           
385                 390                 395                 400           

agc atc gtg agt ccc ttt ata ccg ctg tta cca att ttc ttt tgt ctc       1248
Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu           
                405                 410                 415               

tgg gta tac att taa taa                                               1266
Trp Val Tyr Ile                                                           
            420                                                           


<210>  28
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  28

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser Leu Glu Trp Arg Asn 
            20                  25                  30          


Val Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Pro Asn Ser Ser Ile 
        35                  40                  45              


Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro Gly Cys Val Pro 
    50                  55                  60                  


Cys Val Gln Asp Gly Asn Ile Ser Thr Cys Trp Thr Ser Val Thr Pro 
65                  70                  75                  80  


Thr Val Ala Val Arg Tyr Leu Gly Ala Thr Thr Ala Ser Val Arg Ser 
                85                  90                  95      


His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr 
            100                 105                 110         


Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly Gln Ala Phe Thr 
        115                 120                 125             


Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys Asn Cys Ser Leu 
    130                 135                 140                 


Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp Asp Met Met Met 
145                 150                 155                 160 


Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His Val Leu Arg Leu 
                165                 170                 175     


Pro Gln Thr Leu Phe Asp Ile Ile Ala Gly Ala His Trp Gly Ile Leu 
            180                 185                 190         


Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp Ala Lys Val Ala 
        195                 200                 205             


Val Ile Met Ile Met Phe Ser Gly Thr Arg Ile Leu Thr Ile Pro Gln 
    210                 215                 220                 


Ser Leu Asp Ser Trp Trp Thr Ser Leu Asn Phe Leu Gly Gly Ser Pro 
225                 230                 235                 240 


Val Cys Leu Gly Gln Asn Ser Gln Ser Pro Thr Ser Asn His Ser Pro 
                245                 250                 255     


Thr Ser Cys Pro Pro Ile Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg 
            260                 265                 270         


Arg Phe Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu 
        275                 280                 285             


Leu Val Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile 
    290                 295                 300                 


Pro Gly Ser Thr Thr Thr Ser Thr Gly Pro Cys Lys Thr Cys Thr Thr 
305                 310                 315                 320 


Pro Ala Gln Gly Asn Ser Met Phe Pro Ser Cys Cys Cys Thr Lys Pro 
                325                 330                 335     


Thr Asp Gly Asn Cys Thr Cys Ile Pro Ile Pro Ser Ser Trp Ala Phe 
            340                 345                 350         


Ala Lys Tyr Leu Trp Glu Trp Ala Ser Val Arg Phe Ser Trp Leu Ser 
        355                 360                 365             


Leu Leu Val Pro Phe Val Gln Trp Phe Val Gly Leu Ser Pro Thr Val 
    370                 375                 380                 


Trp Leu Ser Ala Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr 
385                 390                 395                 400 


Ser Ile Val Ser Pro Phe Ile Pro Leu Leu Pro Ile Phe Phe Cys Leu 
                405                 410                 415     


Trp Val Tyr Ile 
            420 


<210>  29
<211>  9955
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'HPH (hph: gne de rsistance  l'hygromycine)

<400>  29
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccgga ctagtaactc gaggcccctc     8040

tccctccccc ccccctaacg ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt     8100

tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg cccggaaacc     8160

tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca aaggaatgca     8220

aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa gacaaacaac     8280

gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg     8340

ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt gccacgttgt     8400

gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca acaaggggct     8460

gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc ggtacacatg     8520

ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc acggggacgt     8580

ggttttcctt tgaaaaacac gatgataata tggccacaac cttggatgaa aaagcctgaa     8640

ctcaccgcga cgtctgtcga gaagtttctg atcgaaaagt tcgacagcgt ctccgacctg     8700

atgcagctct cggagggcga agaatctcgt gctttcagct tcgatgtagg agggcgtgga     8760

tatgtcctgc gggtaaatag ctgcgccgat ggtttctaca aagatcgtta tgtttatcgg     8820

cactttgcat cggccgcgct cccgattccg gaagtgcttg acattgggga attcagcgag     8880

agcctgacct attgcatctc ccgccgtgca cagggtgtca cgttgcaaga cctgcctgaa     8940

accgaactgc ccgctgttct gcagccggtc gcggaggcca tggatgcgat cgctgcggcc     9000

gatcttagcc agacgagcgg gttcggccca ttcggaccgc aaggaatcgg tcaatacact     9060

acatggcgtg atttcatatg cgcgattgct gatccccatg tgtatcactg gcaaactgtg     9120

atggacgaca ccgtcagtgc gtccgtcgcg caggctctcg atgagctgat gctttgggcc     9180

gaggactgcc ccgaagtccg gcacctcgtg cacgcggatt tcggctccaa caatgtcctg     9240

acggacaatg gccgcataac agcggtcatt gactggagcg aggcgatgtt cggggattcc     9300

caatacgagg tcgccaacat cttcttctgg aggccgtggt tggcttgtat ggagcagcag     9360

acgcgctact tcgagcggag gcatccggag cttgcaggat cgccgcggct ccgggcgtat     9420

atgctccgca ttggtcttga ccaactctat cagagcttgg ttgacggcaa tttcgatgat     9480

gcagcttggg cgcagggtcg atgcgacgca atcgtccgat ccggagccgg gactgtcggg     9540

cgtacacaaa tcgcccgcag aagcgcggcc gtctggaccg atggctgtgt agaagtactc     9600

gccgatagtg gaaaccgacg ccccagcact cgtccgaggg caaaggaata gtaaggtacc     9660

tttaagacca atgacttaca aggcagctgt agatcttagc cactttttaa aagaaaaggg     9720

gggactggaa gggctaattc actcccaacg aagacaagat ctttttgctt gtactgggtc     9780

tctctggtta gaccagatct gagcctggga gctctctggc taactaggga acccactgct     9840

taagcctcaa taaagcttgc cttgagtgct tcaagtagtg tgtgcccgtc tgttgtgtga     9900

ctctggtaac tagagatccc tcagaccctt ttagtcagtg tggaaaatct ctaga          9955


<210>  30
<211>  10645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'HPH-S (hph : gne de rsistance  l'hygromycine / S 
       : squence codant la protine S sauvage au niveau du site BamHI)

<400>  30
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccatg gagaacatca catcaggatt     8040

cctaggaccc ctgctcgtgt tacaggcggg gtttttcttg ttgacaagaa tcctcacaat     8100

accgcagagt ctagactcgt ggtggacttc tctcaatttt ctagggggat ctcccgtgtg     8160

tcttggccaa aattcgcagt ccccaacctc caatcactca ccaacctcct gtcctccaat     8220

ttgtcctggt tatcgctgga tgtgtctgcg gcgttttatc atattcctct tcatcctgct     8280

gctatgcctc atcttcttat tggttcttct ggattatcaa ggtatgttgc ccgtttgtcc     8340

tctaattcca ggatcaacaa caaccagtac gggaccatgc aaaacctgca cgactcctgc     8400

tcaaggcaac tctatgtttc cctcatgttg ctgtacaaaa cctacggatg gaaattgcac     8460

ctgtattccc atcccatcgt cctgggcttt cgcaaaatac ctatgggagt gggcctcagt     8520

ccgtttctct tggctcagtt tactagtgcc atttgttcag tggttcgtag ggctttcccc     8580

cactgtttgg ctttcagcta tatggatgat gtggtattgg gggccaagtc tgtacagcat     8640

cgtgagtccc tttataccgc tgttaccaat tttcttttgt ctctgggtat acatttaata     8700

aggatccgga ctagtaactc gaggcccctc tccctccccc ccccctaacg ttactggccg     8760

aagccgcttg gaataaggcc ggtgtgcgtt tgtctatatg ttattttcca ccatattgcc     8820

gtcttttggc aatgtgaggg cccggaaacc tggccctgtc ttcttgacga gcattcctag     8880

gggtctttcc cctctcgcca aaggaatgca aggtctgttg aatgtcgtga aggaagcagt     8940

tcctctggaa gcttcttgaa gacaaacaac gtctgtagcg accctttgca ggcagcggaa     9000

ccccccacct ggcgacaggt gcctctgcgg ccaaaagcca cgtgtataag atacacctgc     9060

aaaggcggca caaccccagt gccacgttgt gagttggata gttgtggaaa gagtcaaatg     9120

gctctcctca agcgtattca acaaggggct gaaggatgcc cagaaggtac cccattgtat     9180

gggatctgat ctggggcctc ggtacacatg ctttacatgt gtttagtcga ggttaaaaaa     9240

acgtctaggc cccccgaacc acggggacgt ggttttcctt tgaaaaacac gatgataata     9300

tggccacaac cttggatgaa aaagcctgaa ctcaccgcga cgtctgtcga gaagtttctg     9360

atcgaaaagt tcgacagcgt ctccgacctg atgcagctct cggagggcga agaatctcgt     9420

gctttcagct tcgatgtagg agggcgtgga tatgtcctgc gggtaaatag ctgcgccgat     9480

ggtttctaca aagatcgtta tgtttatcgg cactttgcat cggccgcgct cccgattccg     9540

gaagtgcttg acattgggga attcagcgag agcctgacct attgcatctc ccgccgtgca     9600

cagggtgtca cgttgcaaga cctgcctgaa accgaactgc ccgctgttct gcagccggtc     9660

gcggaggcca tggatgcgat cgctgcggcc gatcttagcc agacgagcgg gttcggccca     9720

ttcggaccgc aaggaatcgg tcaatacact acatggcgtg atttcatatg cgcgattgct     9780

gatccccatg tgtatcactg gcaaactgtg atggacgaca ccgtcagtgc gtccgtcgcg     9840

caggctctcg atgagctgat gctttgggcc gaggactgcc ccgaagtccg gcacctcgtg     9900

cacgcggatt tcggctccaa caatgtcctg acggacaatg gccgcataac agcggtcatt     9960

gactggagcg aggcgatgtt cggggattcc caatacgagg tcgccaacat cttcttctgg    10020

aggccgtggt tggcttgtat ggagcagcag acgcgctact tcgagcggag gcatccggag    10080

cttgcaggat cgccgcggct ccgggcgtat atgctccgca ttggtcttga ccaactctat    10140

cagagcttgg ttgacggcaa tttcgatgat gcagcttggg cgcagggtcg atgcgacgca    10200

atcgtccgat ccggagccgg gactgtcggg cgtacacaaa tcgcccgcag aagcgcggcc    10260

gtctggaccg atggctgtgt agaagtactc gccgatagtg gaaaccgacg ccccagcact    10320

cgtccgaggg caaaggaata gtaaggtacc tttaagacca atgacttaca aggcagctgt    10380

agatcttagc cactttttaa aagaaaaggg gggactggaa gggctaattc actcccaacg    10440

aagacaagat ctttttgctt gtactgggtc tctctggtta gaccagatct gagcctggga    10500

gctctctggc taactaggga acccactgct taagcctcaa taaagcttgc cttgagtgct    10560

tcaagtagtg tgtgcccgtc tgttgtgtga ctctggtaac tagagatccc tcagaccctt    10620

ttagtcagtg tggaaaatct ctaga                                          10645


<210>  31
<211>  9529
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'PAC (pac : gne de rsistance  la puromycine)

<400>  31
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccgga ctagtaactc gaggcccctc     8040

tccctccccc ccccctaacg ttactggccg aagccgcttg gaataaggcc ggtgtgcgtt     8100

tgtctatatg ttattttcca ccatattgcc gtcttttggc aatgtgaggg cccggaaacc     8160

tggccctgtc ttcttgacga gcattcctag gggtctttcc cctctcgcca aaggaatgca     8220

aggtctgttg aatgtcgtga aggaagcagt tcctctggaa gcttcttgaa gacaaacaac     8280

gtctgtagcg accctttgca ggcagcggaa ccccccacct ggcgacaggt gcctctgcgg     8340

ccaaaagcca cgtgtataag atacacctgc aaaggcggca caaccccagt gccacgttgt     8400

gagttggata gttgtggaaa gagtcaaatg gctctcctca agcgtattca acaaggggct     8460

gaaggatgcc cagaaggtac cccattgtat gggatctgat ctggggcctc ggtacacatg     8520

ctttacatgt gtttagtcga ggttaaaaaa acgtctaggc cccccgaacc acggggacgt     8580

ggttttcctt tgaaaaacac gatgataata tggccacaac cttggatgac cgagtacaag     8640

cccacggtgc gcctcgccac ccgcgacgac gtcccccggg ccgtacgcac cctcgccgcc     8700

gcgttcgccg actaccccgc cacgcgccac accgtcgacc cggaccgcca catcgagcgg     8760

gtcaccgagc tgcaagaact cttcctcacg cgcgtcgggc tcgacatcgg caaggtgtgg     8820

gtcgcggacg acggcgccgc ggtggcggtc tggaccacgc cggagagcgt cgaagcgggg     8880

gcggtgttcg ccgagatcgg cccgcgcatg gccgagttga gcggttcccg gctggccgcg     8940

cagcaacaga tggaaggcct cctggcgccg caccggccca aggagcccgc gtggttcctg     9000

gccaccgtcg gcgtctcgcc cgaccaccag ggcaagggtc tgggcagcgc cgtcgtgctc     9060

cccggagtgg aggcggccga gcgcgccggg gtgcccgcct tcctggagac ctccgcgccc     9120

cgcaacctcc ccttctacga gcggctcggc ttcaccgtca ccgccgacgt cgaggtgccc     9180

gaaggaccgc gcacctggtg catgacccgc aagcccggtg cctgataagg tacctttaag     9240

accaatgact tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact     9300

ggaagggcta attcactccc aacgaagaca agatcttttt gcttgtactg ggtctctctg     9360

gttagaccag atctgagcct gggagctctc tggctaacta gggaacccac tgcttaagcc     9420

tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg     9480

taactagaga tccctcagac ccttttagtc agtgtggaaa atctctaga                 9529


<210>  32
<211>  10801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'PAC - G4A E1-S (pac : gne de rsistance  la 
       puromycine / G4A E1-S : squence codant la protine fusion " E1 
       du virus HCV de gnotype 4a - Protine S dlte du virus HBV de 
       srotype adw " au niveau du site BamHI)

<400>  32
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccatg acagggaatc ttcctggttg     8040

ctctttttct atcttccttt tggcacttct ctcgtgcctg actgtccccg cttcggccgt     8100

taactaccgc aacacctcgg gcatctacca catcaccaat gactgcccga attcaagcat     8160

agtttatgag gccgaccatc acatcttgca ccttccaggt tgcgtgccct gcgtgaaaac     8220

ggggaatcga tcacgttgct gggtggccct tactcctact gtcgcagcgc catacatcgg     8280

cgcgccgctt cactctctac ggagtcatgt ggatctgatg gtgggggctg ctaccgtttg     8340

ttcagccctt tacataggag atttgtgtgg cggcttattc ttggctggtc aggtgttctc     8400

tttccgacca cggcgccact ggactaccca ggattgcaat tgttccatct acacagggca     8460

catcaccggg catagaatgg cctggggcat gatgatgaac tggagtccaa caactaccct     8520

agtccttagc cagatcatga ggatcccagg taccctagta gacttgctcg ctgggggcca     8580

ctggggtgtc cttgtgggag tggcttatta cagcatgcaa gctaattggg ccaaagtcat     8640

cttggtccta ttcctcttcg cgggtacaag aatcctcaca ataccgcaga gtctagactc     8700

gtggtggact tctctcaatt ttctaggggg atctcccgtg tgtcttggcc aaaattcgca     8760

gtccccaacc tccaatcact caccaacctc ctgtcctcca atttgtcctg gttatcgctg     8820

gatgtgtctg cggcgtttta tcatattcct cttcatcctg ctgctatgcc tcatcttctt     8880

attggttctt ctggattatc aaggtatgtt gcccgtttgt cctctaattc caggatcaac     8940

aacaaccagt acgggaccat gcaaaacctg cacgactcct gctcaaggca actctatgtt     9000

tccctcatgt tgctgtacaa aacctacgga tggaaattgc acctgtattc ccatcccatc     9060

gtcctgggct ttcgcaaaat acctatggga gtgggcctca gtccgtttct cttggctcag     9120

tttactagtg ccatttgttc agtggttcgt agggctttcc cccactgttt ggctttcagc     9180

tatatggatg atgtggtatt gggggccaag tctgtacagc atcgtgagtc cctttatacc     9240

gctgttacca attttctttt gtctctgggt atacatttaa taaggatccg gactagtaac     9300

tcgaggcccc tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg     9360

ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag     9420

ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc     9480

caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg     9540

aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag     9600

gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca     9660

gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt     9720

caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc     9780

tcggtacaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa     9840

ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca accttggatg     9900

accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtcccccg ggccgtacgc     9960

accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga cccggaccgc    10020

cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc    10080

ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc    10140

gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc    10200

cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc    10260

gcgtggttcc tggccaccgt cggcgtctcg cccgaccacc agggcaaggg tctgggcagc    10320

gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag    10380

acctccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac    10440

gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgataa    10500

ggtaccttta agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga    10560

aaagggggga ctggaagggc taattcactc ccaacgaaga caagatcttt ttgcttgtac    10620

tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc    10680

actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt    10740

gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag    10800

a                                                                    10801


<210>  33
<211>  11290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'PAC - G4A E2-S (pac : gne de rsistance  la 
       puromycine / G4A E2-S : squence codant la protine fusion " E2 
       du virus HCV de gnotype 4a - Protine S dlte du virus HBV de 
       srotype adw " au niveau du site BamHI)

<400>  33
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccatg gctaattggg ccaaagtcat     8040

cttggtccta ttcctcttcg caggggttga cgctaacacc cacacgactg gaggcgcggc     8100

cggcctacaa actcgtggtt ttactgggct cttcctccct ggagctaaac aaaacttgca     8160

gctcattaac accaatggga gctggcatat aaacaggact gccctcaact gcaatgacag     8220

cttaaacact gggttcttgg ctagcttgtt ctacaccaac aagtttaaca gttcagggtg     8280

tcctgaacga cttgcaagct gcagaagcct tgatactttc aaccaaggct ggggcccact     8340

tggggtcgct aacatcagtg actctgatga caggccttat tgctggcact acccccctcg     8400

accgtgcggg attgtgccgg cacgcagtgt gtgtggcccc gtgtattgct ttactcccag     8460

ccccgtcgtg gtcgggacaa ctgatcgcct tggggtcccc acgtacacct ggggggagaa     8520

tgagtctgat gccttcctgt tgaactcgac caggccgcca caaggtgcgt ggtttggatg     8580

cgtgtggatg aacagcaccg ggtttacaaa agcctgtgga gctcctccat gcgaggttac     8640

cagagccaat aataaaacct ggcactgccc cactgattgt ttcaggaagc atccggagac     8700

cacctatgcc aaatgcggat caggcccctg gatcacacca cgatgcttga ttgactaccg     8760

gtatcggctg tggcaattac catgcaccgt caactcttct gtctttaaag tcaggaccta     8820

tatggccggt aagaagcatc ggatgcagcc agcatgcaac tggactaggg gggaagtctt     8880

gggcttggag cacagggatc gggtagagct atcacccctg ctccttacca ctacagcgtg     8940

gcagatcctc ccctgctctt tcaccacttt accagccctt tctaccggct tgatccacct     9000

ccaccaaaat atcgtggacg tccagtacct ctacggtgtt ggatctgcag tggtatcttg     9060

ggccctcaaa tgggaatatg tggtgctcgt gttcctgctt cttgcagacg cgagagtctc     9120

tgcttgccta tggatgatgt ttatggtatc tcagacaaga atcctcacaa taccgcagag     9180

tctagactcg tggtggactt ctctcaattt tctaggggga tctcccgtgt gtcttggcca     9240

aaattcgcag tccccaacct ccaatcactc accaacctcc tgtcctccaa tttgtcctgg     9300

ttatcgctgg atgtgtctgc ggcgttttat catattcctc ttcatcctgc tgctatgcct     9360

catcttctta ttggttcttc tggattatca aggtatgttg cccgtttgtc ctctaattcc     9420

aggatcaaca acaaccagta cgggaccatg caaaacctgc acgactcctg ctcaaggcaa     9480

ctctatgttt ccctcatgtt gctgtacaaa acctacggat ggaaattgca cctgtattcc     9540

catcccatcg tcctgggctt tcgcaaaata cctatgggag tgggcctcag tccgtttctc     9600

ttggctcagt ttactagtgc catttgttca gtggttcgta gggctttccc ccactgtttg     9660

gctttcagct atatggatga tgtggtattg ggggccaagt ctgtacagca tcgtgagtcc     9720

ctttataccg ctgttaccaa ttttcttttg tctctgggta tacatttaat aaggatccgg     9780

actagtaact cgaggcccct ctccctcccc cccccctaac gttactggcc gaagccgctt     9840

ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc cgtcttttgg     9900

caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta ggggtctttc     9960

ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga    10020

agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga accccccacc    10080

tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg caaaggcggc    10140

acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat ggctctcctc    10200

aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga    10260

tctggggcct cggtacacat gctttacatg tgtttagtcg aggttaaaaa aacgtctagg    10320

ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat atggccacaa    10380

ccttggatga ccgagtacaa gcccacggtg cgcctcgcca cccgcgacga cgtcccccgg    10440

gccgtacgca ccctcgccgc cgcgttcgcc gactaccccg ccacgcgcca caccgtcgac    10500

ccggaccgcc acatcgagcg ggtcaccgag ctgcaagaac tcttcctcac gcgcgtcggg    10560

ctcgacatcg gcaaggtgtg ggtcgcggac gacggcgccg cggtggcggt ctggaccacg    10620

ccggagagcg tcgaagcggg ggcggtgttc gccgagatcg gcccgcgcat ggccgagttg    10680

agcggttccc ggctggccgc gcagcaacag atggaaggcc tcctggcgcc gcaccggccc    10740

aaggagcccg cgtggttcct ggccaccgtc ggcgtctcgc ccgaccacca gggcaagggt    10800

ctgggcagcg ccgtcgtgct ccccggagtg gaggcggccg agcgcgccgg ggtgcccgcc    10860

ttcctggaga cctccgcgcc ccgcaacctc cccttctacg agcggctcgg cttcaccgtc    10920

accgccgacg tcgaggtgcc cgaaggaccg cgcacctggt gcatgacccg caagcccggt    10980

gcctgataag gtacctttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt    11040

tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctttt    11100

tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact    11160

agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc    11220

ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa    11280

aatctctaga                                                           11290


<210>  34
<211>  11290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'PAC - G1A E2-S (pac : gne de rsistance  la 
       puromycine / G1A E2-S : squence codant la protine fusion " E2 
       du virus HCV de gnotype 1a - Protine S dlte du virus HBV de 
       srotype adw " au niveau du site BamHI)

<400>  34
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccatg gggaactggg cgaaggtcct     8040

ggtggtgctg ttgctgttcg ccagcgtcga tgcggaaacc tacaccaccg gggggagtat     8100

tgccaaaacc gtgcaaggat tcaccagttt ttttacccca ggcgccaagc aggacatcca     8160

gctgatcaac accaacggca gttggcacat caatcgcacg gccttgaact gtaatgcgag     8220

cctcgaaacc ggctggatag cggggctctt ctactacaac aaattcaact cctcaggctg     8280

ccccgagagg atggccagct gcaaacccct tgcctatttc gcccaaggct ggggccctat     8340

cagccatgtc aacggaagcg gccccgaaca gcgcccctac tgctggcact acgccccaag     8400

gccttgtggt atcgtgtcag cacagacagt atgtggccca gtgtattgtt tcactcctag     8460

ccccgtggtg gtggggacga ccgacaagtt gggcgcgcct acctacaact ggggtgagaa     8520

tgatacggac gtcttcgtcc tcaataacac caggccaccg ttgggcaatt ggttcggttg     8580

cacctggatg aactcatctg gattcaccaa agtgtgcgga gcgcctccct gtgccatcgg     8640

aggagtgggc aataacacct tgcgctgtcc cactgactgt ttccgcaagc atccggaagc     8700

tacatactct cgatgtggct ccggtccctg gatcacgccc aggtgcctgg tcgactatcc     8760

ttataggctc tggcattatc cttgcactgt caactacacc ctgtttaaaa tcaggatgta     8820

cgtgggaggg gtcgagcaca ggctacaagc tgcttgcaac tggacgcggg gcgagcgttg     8880

tgatctggac gacagggaca ggtccgagct cagcccgctg ctgctgtcca ccacgcagtg     8940

gcaggtcctt ccgtgttctt tcacgacctt gccagccttg accaccggcc tcatccacct     9000

ccatcagaac atcgtggacg tgcaatattt gtacggggtg gggtcaagca ttgtgtcctg     9060

ggccatcaag tgggagtacg tcattctctt gtttctcctg cttgcagacg cgcgcatctg     9120

ctcctgcttg tggatgatgc tactcatatc ccaaacaaga atcctcacaa taccgcagag     9180

tctagactcg tggtggactt ctctcaattt tctaggggga tctcccgtgt gtcttggcca     9240

aaattcgcag tccccaacct ccaatcactc accaacctcc tgtcctccaa tttgtcctgg     9300

ttatcgctgg atgtgtctgc ggcgttttat catattcctc ttcatcctgc tgctatgcct     9360

catcttctta ttggttcttc tggattatca aggtatgttg cccgtttgtc ctctaattcc     9420

aggatcaaca acaaccagta cgggaccatg caaaacctgc acgactcctg ctcaaggcaa     9480

ctctatgttt ccctcatgtt gctgtacaaa acctacggat ggaaattgca cctgtattcc     9540

catcccatcg tcctgggctt tcgcaaaata cctatgggag tgggcctcag tccgtttctc     9600

ttggctcagt ttactagtgc catttgttca gtggttcgta gggctttccc ccactgtttg     9660

gctttcagct atatggatga tgtggtattg ggggccaagt ctgtacagca tcgtgagtcc     9720

ctttataccg ctgttaccaa ttttcttttg tctctgggta tacatttaat aaggatccgg     9780

actagtaact cgaggcccct ctccctcccc cccccctaac gttactggcc gaagccgctt     9840

ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc cgtcttttgg     9900

caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta ggggtctttc     9960

ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga    10020

agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga accccccacc    10080

tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg caaaggcggc    10140

acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat ggctctcctc    10200

aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga    10260

tctggggcct cggtacacat gctttacatg tgtttagtcg aggttaaaaa aacgtctagg    10320

ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat atggccacaa    10380

ccttggatga ccgagtacaa gcccacggtg cgcctcgcca cccgcgacga cgtcccccgg    10440

gccgtacgca ccctcgccgc cgcgttcgcc gactaccccg ccacgcgcca caccgtcgac    10500

ccggaccgcc acatcgagcg ggtcaccgag ctgcaagaac tcttcctcac gcgcgtcggg    10560

ctcgacatcg gcaaggtgtg ggtcgcggac gacggcgccg cggtggcggt ctggaccacg    10620

ccggagagcg tcgaagcggg ggcggtgttc gccgagatcg gcccgcgcat ggccgagttg    10680

agcggttccc ggctggccgc gcagcaacag atggaaggcc tcctggcgcc gcaccggccc    10740

aaggagcccg cgtggttcct ggccaccgtc ggcgtctcgc ccgaccacca gggcaagggt    10800

ctgggcagcg ccgtcgtgct ccccggagtg gaggcggccg agcgcgccgg ggtgcccgcc    10860

ttcctggaga cctccgcgcc ccgcaacctc cccttctacg agcggctcgg cttcaccgtc    10920

accgccgacg tcgaggtgcc cgaaggaccg cgcacctggt gcatgacccg caagcccggt    10980

gcctgataag gtacctttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt    11040

tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctttt    11100

tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact    11160

agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc    11220

ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa    11280

aatctctaga                                                           11290


<210>  35
<211>  11290
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'PAC - G3A E2-S (pac : gne de rsistance  la 
       puromycine / G3A E2-S : squence codant la protine fusion " E2 
       du virus HCV de gnotype 3a - Protine S dlte du virus HBV de 
       srotype adw " au niveau du site BamHI)

<400>  35
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccatg ggcaattggg ccaaggtcgc     8040

tgtcatcatg actatgtttt caggggtcga tgccgcaaca tacatcaccg gtggcacagt     8100

agctcatact actaataggt tcaccagcat tttcagtatg ggcgctcaac agaaattgca     8160

gctggtcaac gccaatggct cgtggcacat caacagaact gccctgaatt gtaatgagtc     8220

cataaacacc gggttcatag ctgggttgtt ttactatcat aagttcaatt ctactggatg     8280

tcctcaaagg ctcagcagct gcaagcccat tactttcttt aagcaggggt ggggcccctt     8340

aggagatgct aacatcaccg gtcctgctga caaaccatac tgctggcact acgcacctag     8400

atcttgtgac gttgtctcgg cattaagtgt ctgcggccct gtatactgct tcacaccatc     8460

gccagtagtc gtaggcacta ctgatgttag gggcgcgcca acttacaact ggggtgagaa     8520

tgagacagac gtgttcctgc tgaagtcctt gcggcctccc agtggtcagt ggtttgggtg     8580

cgcgtggatg aactcctcgg ggtttctcaa gacgtgcgga gctccccctt gtaacatcgg     8640

ggtagtgggg agtcagacct catgctgccc caccgactgc ttcaggaagc accctgaggc     8700

tacatacagc cggtgtggtg cagggccctg ggttacacct cgatgcatgg tcgactaccc     8760

ataccggctc tggcattacc catgtacagt caatttcaca ttgttcaagg tgaggatgtt     8820

cgtgggtggg ttcgagcacc ggtttaccgc cgcttgcaac tggaccaggg gggagcgctg     8880

cgatatcgaa gatcgtgacc gcagcgagca acatccactg ttgcattcaa caaccgagct     8940

tgccatactg ccttgctctt tcacgcccat gcctgcactg tcaacaggtc taatacacct     9000

ccaccaaaac atcgtggatg tccaatacct ttatggcgtt ggatctggca tggtgggatg     9060

ggcgctgaaa tgggagttcg tcatcctcat tttcctcctc ctagcggacc gacgcgtgtg     9120

cgttgccctt tggctgatgc tgatgatatc acaaacaaga atcctcacaa taccgcagag     9180

tctagactcg tggtggactt ctctcaattt tctaggggga tctcccgtgt gtcttggcca     9240

aaattcgcag tccccaacct ccaatcactc accaacctcc tgtcctccaa tttgtcctgg     9300

ttatcgctgg atgtgtctgc ggcgttttat catattcctc ttcatcctgc tgctatgcct     9360

catcttctta ttggttcttc tggattatca aggtatgttg cccgtttgtc ctctaattcc     9420

aggatcaaca acaaccagta cgggaccatg caaaacctgc acgactcctg ctcaaggcaa     9480

ctctatgttt ccctcatgtt gctgtacaaa acctacggat ggaaattgca cctgtattcc     9540

catcccatcg tcctgggctt tcgcaaaata cctatgggag tgggcctcag tccgtttctc     9600

ttggctcagt ttactagtgc catttgttca gtggttcgta gggctttccc ccactgtttg     9660

gctttcagct atatggatga tgtggtattg ggggccaagt ctgtacagca tcgtgagtcc     9720

ctttataccg ctgttaccaa ttttcttttg tctctgggta tacatttaat aaggatccgg     9780

actagtaact cgaggcccct ctccctcccc cccccctaac gttactggcc gaagccgctt     9840

ggaataaggc cggtgtgcgt ttgtctatat gttattttcc accatattgc cgtcttttgg     9900

caatgtgagg gcccggaaac ctggccctgt cttcttgacg agcattccta ggggtctttc     9960

ccctctcgcc aaaggaatgc aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga    10020

agcttcttga agacaaacaa cgtctgtagc gaccctttgc aggcagcgga accccccacc    10080

tggcgacagg tgcctctgcg gccaaaagcc acgtgtataa gatacacctg caaaggcggc    10140

acaaccccag tgccacgttg tgagttggat agttgtggaa agagtcaaat ggctctcctc    10200

aagcgtattc aacaaggggc tgaaggatgc ccagaaggta ccccattgta tgggatctga    10260

tctggggcct cggtacacat gctttacatg tgtttagtcg aggttaaaaa aacgtctagg    10320

ccccccgaac cacggggacg tggttttcct ttgaaaaaca cgatgataat atggccacaa    10380

ccttggatga ccgagtacaa gcccacggtg cgcctcgcca cccgcgacga cgtcccccgg    10440

gccgtacgca ccctcgccgc cgcgttcgcc gactaccccg ccacgcgcca caccgtcgac    10500

ccggaccgcc acatcgagcg ggtcaccgag ctgcaagaac tcttcctcac gcgcgtcggg    10560

ctcgacatcg gcaaggtgtg ggtcgcggac gacggcgccg cggtggcggt ctggaccacg    10620

ccggagagcg tcgaagcggg ggcggtgttc gccgagatcg gcccgcgcat ggccgagttg    10680

agcggttccc ggctggccgc gcagcaacag atggaaggcc tcctggcgcc gcaccggccc    10740

aaggagcccg cgtggttcct ggccaccgtc ggcgtctcgc ccgaccacca gggcaagggt    10800

ctgggcagcg ccgtcgtgct ccccggagtg gaggcggccg agcgcgccgg ggtgcccgcc    10860

ttcctggaga cctccgcgcc ccgcaacctc cccttctacg agcggctcgg cttcaccgtc    10920

accgccgacg tcgaggtgcc cgaaggaccg cgcacctggt gcatgacccg caagcccggt    10980

gcctgataag gtacctttaa gaccaatgac ttacaaggca gctgtagatc ttagccactt    11040

tttaaaagaa aaggggggac tggaagggct aattcactcc caacgaagac aagatctttt    11100

tgcttgtact gggtctctct ggttagacca gatctgagcc tgggagctct ctggctaact    11160

agggaaccca ctgcttaagc ctcaataaag cttgccttga gtgcttcaag tagtgtgtgc    11220

ccgtctgttg tgtgactctg gtaactagag atccctcaga cccttttagt cagtgtggaa    11280

aatctctaga                                                           11290


<210>  36
<211>  10801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'PAC - G1A E1-S (pac : gne de rsistance  la 
       puromycine / G1A E1-S : squence codant la protine fusion " E1 
       du virus HCV de gnotype 1a - Protine S dlte du virus HBV de 
       srotype adw " au niveau du site BamHI)

<400>  36
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccatg acagggaacc ttcctggttg     8040

ctctttctct atcttccttc tggccctgct ctcttgcctg actgtgcccg cgtcagccta     8100

ccaagtacgc aactcctcgg gcctttacca tgtcaccaat gattgcccta actcgagtat     8160

tgtgtacgag acggccgata ccatcctaca ctctccgggg tgtgtccctt gcgttcgcga     8220

gggcaatgcc tcaaaatgtt gggtggcggt ggcccctaca gtcgccacca gagacggcaa     8280

gctccccaca acgcagcttc gacgtcacat cgatctgctc gtcaggagcg ccaccctctg     8340

ctcggccctc tatgtggggg acttgtgcgg gtccgtcttc ctcgtcggtc aactgttcac     8400

cttctccccc aggcgccact ggacaacgca agactgcaac tgttccatgt accccggcca     8460

tataacgggt caccgtatgg catgggacat gatgatgaac tggtccccta cgacagcgct     8520

ggtagtagct cagctgctca gggtcccgca agccatcttg gacatgatcg ctggtgccca     8580

ctggggagtc ctagcgggca tagcgtattt ctccatggtg gggaactggg cgaaggtcct     8640

ggtggtgctg ttgctgttcg ccagcacaag aatcctcaca ataccgcaga gtctagactc     8700

gtggtggact tctctcaatt ttctaggggg atctcccgtg tgtcttggcc aaaattcgca     8760

gtccccaacc tccaatcact caccaacctc ctgtcctcca atttgtcctg gttatcgctg     8820

gatgtgtctg cggcgtttta tcatattcct cttcatcctg ctgctatgcc tcatcttctt     8880

attggttctt ctggattatc aaggtatgtt gcccgtttgt cctctaattc caggatcaac     8940

aacaaccagt acgggaccat gcaaaacctg cacgactcct gctcaaggca actctatgtt     9000

tccctcatgt tgctgtacaa aacctacgga tggaaattgc acctgtattc ccatcccatc     9060

gtcctgggct ttcgcaaaat acctatggga gtgggcctca gtccgtttct cttggctcag     9120

tttactagtg ccatttgttc agtggttcgt agggctttcc cccactgttt ggctttcagc     9180

tatatggatg atgtggtatt gggggccaag tctgtacagc atcgtgagtc cctttatacc     9240

gctgttacca attttctttt gtctctgggt atacatttaa taaggatccg gactagtaac     9300

tcgaggcccc tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg     9360

ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag     9420

ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc     9480

caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg     9540

aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag     9600

gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca     9660

gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt     9720

caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc     9780

tcggtacaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa     9840

ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca accttggatg     9900

accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtcccccg ggccgtacgc     9960

accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga cccggaccgc    10020

cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc    10080

ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc    10140

gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc    10200

cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc    10260

gcgtggttcc tggccaccgt cggcgtctcg cccgaccacc agggcaaggg tctgggcagc    10320

gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag    10380

acctccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac    10440

gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgataa    10500

ggtaccttta agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga    10560

aaagggggga ctggaagggc taattcactc ccaacgaaga caagatcttt ttgcttgtac    10620

tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc    10680

actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt    10740

gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag    10800

a                                                                    10801


<210>  37
<211>  10801
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Plasmide PHR'PAC - G3A E1-S (pac : gne de rsistance  la 
       puromycine / G3A E1-S : squence codant la protine fusion " E1 
       du virus HCV de gnotype 3a - Protine S dlte du virus HBV de 
       srotype adw " au niveau du site BamHI)

<400>  37
ttaattccgt gtattctata gtgtcaccta aatcgtatgt gtatgataca taaggttatg       60

tattaattgt agccgcgttc taacgacaat atgtacaagc ctaattgtgt agcatctggc      120

ttactgaagc agaccctatc atctctctcg taaactgccg tcagagtcgg tttggttgga      180

cgaaccttct gagtttctgg taacgccgtc ccgcacccgg aaatggtcag cgaaccaatc      240

agcagggtca tcgctagcca gatcctctac gccggacgca tcgtggccgg catcaccggc      300

gccacaggtg cggttgctgg cgcctatatc gccgacatca ccgatgggga agatcgggct      360

cgccacttcg ggctcatgag cgcttgtttc ggcgtgggta tggtggcagg ccccgtggcc      420

gggggactgt tgggcgccat ctccttgcat gcaccattcc ttgcggcggc ggtgctcaac      480

ggcctcaacc tactactggg ctgcttccta atgcaggagt cgcataaggg agagcgtcga      540

atggtgcact ctcagtacaa tctgctctga tgccgcatag ttaagccagc cccgacaccc      600

gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg cttacagaca      660

agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg      720

cgcgagacga aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat      780

ggtttcttag acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt      840

atttttctaa atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct      900

tcaataatat tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc      960

cttttttgcg gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa     1020

agatgctgaa gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg     1080

taagatcctt gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt     1140

tctgctatgt ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg     1200

catacactat tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac     1260

ggatggcatg acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc     1320

ggccaactta cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa     1380

catgggggat catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc     1440

aaacgacgag cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt     1500

aactggcgaa ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga     1560

taaagttgca ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa     1620

atctggagcc ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa     1680

gccctcccgt atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa     1740

tagacagatc gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt     1800

ttactcatat atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt     1860

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     1920

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     1980

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     2040

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     2100

tgtccttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     2160

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     2220

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     2280

gggttcgtgc acacagccca gcttggagcg aacgacctac accgaactga gatacctaca     2340

gcgtgagcat tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt     2400

aagcggcagg gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta     2460

tctttatagt cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc     2520

gtcagggggg cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc     2580

cttttgctgg ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa     2640

ccgtattacc gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag     2700

cgagtcagtg agcgaggaag cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg     2760

ttggccgatt cattaatgca gctgtggaat gtgtgtcagt tagggtgtgg aaagtcccca     2820

ggctccccag caggcagaag tatgcaaagc atgcatctca attagtcagc aaccaggtgt     2880

ggaaagtccc caggctcccc agcaggcaga agtatgcaaa gcatgcatct caattagtca     2940

gcaaccatag tcccgcccct aactccgccc atcccgcccc taactccgcc cagttccgcc     3000

cattctccgc cccatggctg actaattttt tttatttatg cagaggccga ggccgcctcg     3060

gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctagg cttttgcaaa     3120

aagcttggac acaagacagg cttgcgagat atgtttgaga ataccacttt atcccgcgtc     3180

agggagaggc agtgcgtaaa aagacgcgga ctcatgtgaa atactggttt ttagtgcgcc     3240

agatctctat aatctcgcgc aacctatttt cccctcgaac actttttaag ccgtagataa     3300

acaggctggg acacttcaca tgagcgaaaa atacatcgtc acctgggaca tgttgcagat     3360

ccatgcacgt aaactcgcaa gccgactgat gccttctgaa caatggaaag gcattattgc     3420

cgtaagccgt ggcggtctgt accgggtgcg ttactggcgc gtgaactggg tattcgtcat     3480

gtcgataccg tttgtatttc cagctacgat cacgacaacc agcgcgagct taaagtgctg     3540

aaacgcgcag aaggcgatgg cgaaggcttc atcgttattg atgacctggt ggataccggt     3600

ggtactgcgg ttgcgattcg tgaaatgtat ccaaaagcgc actttgtcac catcttcgca     3660

aaaccggctg gtcgtccgct ggttgatgac tatgttgttg atatcccgca agatacctgg     3720

attgaacagc cgtgggatat gggcgtcgta ttcgtcccgc caatctccgg tcgctaatct     3780

tttcaacgcc tggcactgcc gggcgttgtt ctttttaact tcaggcgggt tacaatagtt     3840

tccagtaagt attctggagg ctgcatccat gacacaggca aacctgagcg aaaccctgtt     3900

caaaccccgc tttaaacatc ctgaaacctc gacgctagtc cgccgcttta atcacggcgc     3960

acaaccgcct gtgcagtcgg cccttgatgg taaaaccatc cctcactggt atcgcatgat     4020

taaccgtctg atgtggatct ggcgcggcat tgacccacgc gaaatcctcg acgtccaggc     4080

acgtattgtg atgagcgatg ccgaacgtac cgacgatgat ttatacgata cggtgattgg     4140

ctaccgtggc ggcaactgga tttatgagtg ggccccggat ctttgtgaag gaaccttact     4200

tctgtggtgt gacataattg gacaaactac ctacagagat ttaaagctct aaggtaaata     4260

taaaattttt aagtgtataa tgtgttaaac tactgattct aattgtttgt gtattttaga     4320

ttccaaccta tggaactgat gaatgggagc agtggtggaa tgcctttaat gaggaaaacc     4380

tgttttgctc agaagaaatg ccatctagtg atgatgaggc tactgctgac tctcaacatt     4440

ctactcctcc aaaaaagaag agaaaggtag aagaccccaa ggactttcct tcagaattgc     4500

taagtttttt gagtcatgct gtgtttagta atagaactct tgcttgcttt gctatttaca     4560

ccacaaagga aaaagctgca ctgctataca agaaaattat ggaaaaatat tctgtaacct     4620

ttataagtag gcataacagt tataatcata acatactgtt ttttcttact ccacacaggc     4680

atagagtgtc tgctattaat aactatgctc aaaaattgtg tacctttagc tttttaattt     4740

gtaaaggggt taataaggaa tatttgatgt atagtgcctt gactagagat cataatcagc     4800

cataccacat ttgtagaggt tttacttgct ttaaaaaacc tcccacacct ccccctgaac     4860

ctgaaacata aaatgaatgc aattgttgtt gttaacttgt ttattgcagc ttataatggt     4920

tacaaataaa gcaatagcat cacaaatttc acaaataaag catttttttc actgcattct     4980

agttgtggtt tgtccaaact catcaatgta tcttatcatg tctggatcaa ctggataact     5040

caagctaacc aaaatcatcc caaacttccc accccatacc ctattaccac tgccaattac     5100

ctagtggttt catttactct aaacctgtga ttcctctgaa ttattttcat tttaaagaaa     5160

ttgtatttgt taaatatgta ctacaaactt agtagttgga agggctaatt cactcccaaa     5220

gaagacaaga tatccttgat ctgtggatct accacacaca aggctacttc cctgattagc     5280

agaactacac accagggcca ggggtcagat atccactgac ctttggatgg tgctacaagc     5340

tagtaccagt tgagccagat aaggtagaag aggccaataa aggagagaac accagcttgt     5400

tacaccctgt gagcctgcat gggatggatg acccggagag agaagtgtta gagtggaggt     5460

ttgacagccg cctagcattt catcacgtgg cccgagagct gcatccggag tacttcaaga     5520

actgctgata tcgagcttgc tacaagggac tttccgctgg ggactttcca gggaggcgtg     5580

gcctgggcgg gactggggag tggcgagccc tcagatcctg catataagca gctgcttttt     5640

gcctgtactg ggtctctctg gttagaccag atctgagcct gggagctctc tggctaacta     5700

gggaacccac tgcttaagcc tcaataaagc ttgccttgag tgcttcaagt agtgtgtgcc     5760

cgtctgttgt gtgactctgg taactagaga tccctcagac ccttttagtc agtgtggaaa     5820

atctctagca gtggcgcccg aacagggact tgaaagcgaa agggaaacca gaggagctct     5880

ctcgacgcag gactcggctt gctgaagcgc gcacggcaag aggcgagggg cggcgactgg     5940

tgagtacgcc aaaaattttg actagcggag gctagaagga gagagatggg tgcgagagcg     6000

tcagtattaa gcgggggaga attagatcgc gatgggaaaa aattcggtta aggccagggg     6060

gaaagaaaaa atataaatta aaacatatag tatgggcaag cagggagcta gaacgattcg     6120

cagttaatcc tggcctgtta gaaacatcag aaggctgtag acaaatactg ggacagctac     6180

aaccatccct tcagacagga tcagaagaac ttagatcatt atataataca gtagcaaccc     6240

tctattgtgt gcatcaaagg atagagataa aagacaccaa ggaagcttta gacaagatag     6300

aggaagagca aaacaaaagt aagaccaccg cacagcaagc ggccgctgat cttcagacct     6360

ggaggaggag atatgaggga caattggaga agtgaattat ataaatataa agtagtaaaa     6420

attgaaccat taggagtagc acccaccaag gcaaagagaa gagtggtgca gagagaaaaa     6480

agagcagtgg gaataggagc tttgttcctt gggttcttgg gagcagcagg aagcactatg     6540

ggcgcagcgt caatgacgct gacggtacag gccagacaat tattgtctgg tatagtgcag     6600

cagcagaaca atttgctgag ggctattgag gcgcaacagc atctgttgca actcacagtc     6660

tggggcatca agcagctcca ggcaagaatc ctggctgtgg aaagatacct aaaggatcaa     6720

cagctcctgg ggatttgggg ttgctctgga aaactcattt gcaccactgc tgtgccttgg     6780

aatgctagtt ggagtaataa atctctggaa cagatttgga atcacacgac ctggatggag     6840

tgggacagag aaattaacaa ttacacaagc ttaatacact ccttaattga agaatcgcaa     6900

aaccagcaag aaaagaatga acaagaatta ttggaattag ataaatgggc aagtttgtgg     6960

aattggttta acataacaaa ttggctgtgg tatataaaat tattcataat gatagtagga     7020

ggcttggtag gtttaagaat agtttttgct gtactttcta tagtgaatag agttaggcag     7080

ggatattcac cattatcgtt tcagacccac ctcccaaccc cgaggggacc cgacaggccc     7140

gaaggaatag aagaagaagg tggagagaga gacagagaca gatccattcg attagtgaac     7200

ggatctcgac ggtatcgccg aattcacaaa tggcagtatt catccacaat tttaaaagaa     7260

aaggggggat tggggggtac agtgcagggg aaagaatagt agacataata gcaacagaca     7320

tacaaactaa agaattacaa aaacaaatta caaaaattca aaattttcgg gtttattaca     7380

gggacagcag agatccactt tatcgataag cttgggagtt ccgcgttaca taacttacgg     7440

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     7500

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     7560

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     7620

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttacgggact     7680

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     7740

ggcagtacac caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     7800

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     7860

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     7920

taagcagagc tcgtttagtg aaccgtcaga tcgcctggag acgccatcca cgctgttttg     7980

acctccatag aagacaccga ctctagctag aggatccatg acagggaact tgcccggttg     8040

ctccttttct atcttcctcc tcgctttgct ctcttgctta atccatccag cagctagtct     8100

agagtggcgg aatgtgtctg gcctctatgt cctcaccaac gactgtccca atagcagtat     8160

tgtgtatgag gccgatgacg tcattctgca cacacccggc tgtgtacctt gtgttcaaga     8220

tggcaacata tccacgtgct ggacctcagt aacacctaca gtggcagtca ggtacctcgg     8280

agcaaccacc gcttcggtac gcagtcatgt ggacttgtta gtgggcgcgg ccacgatgtg     8340

ctctgcgctc tacgtgggtg atatgtgtgg ggctgtcttc cttgtggggc aagccttcac     8400

attcagacct cgtcgccatc aaacagtcca gacctgtaac tgctcgctgt atccaggcca     8460

tctttcagga caccgaatgg cttgggatat gatgatgaat tggtcccctg ctgtgggcat     8520

ggtggtggcg catgtcctgc ggttgcccca gaccctgttc gacataatag ccggggccca     8580

ttggggcatc ttggcgggcc tagcctatta ctccatgcag ggcaattggg ccaaggtcgc     8640

tgtcatcatg attatgtttt cagggacaag aatcctcaca ataccgcaga gtctagactc     8700

gtggtggact tctctcaatt ttctaggggg atctcccgtg tgtcttggcc aaaattcgca     8760

gtccccaacc tccaatcact caccaacctc ctgtcctcca atttgtcctg gttatcgctg     8820

gatgtgtctg cggcgtttta tcatattcct cttcatcctg ctgctatgcc tcatcttctt     8880

attggttctt ctggattatc aaggtatgtt gcccgtttgt cctctaattc caggatcaac     8940

aacaaccagt acgggaccat gcaaaacctg cacgactcct gctcaaggca actctatgtt     9000

tccctcatgt tgctgtacaa aacctacgga tggaaattgc acctgtattc ccatcccatc     9060

gtcctgggct ttcgcaaaat acctatggga gtgggcctca gtccgtttct cttggctcag     9120

tttactagtg ccatttgttc agtggttcgt agggctttcc cccactgttt ggctttcagc     9180

tatatggatg atgtggtatt gggggccaag tctgtacagc atcgtgagtc cctttatacc     9240

gctgttacca attttctttt gtctctgggt atacatttaa taaggatccg gactagtaac     9300

tcgaggcccc tctccctccc ccccccctaa cgttactggc cgaagccgct tggaataagg     9360

ccggtgtgcg tttgtctata tgttattttc caccatattg ccgtcttttg gcaatgtgag     9420

ggcccggaaa cctggccctg tcttcttgac gagcattcct aggggtcttt cccctctcgc     9480

caaaggaatg caaggtctgt tgaatgtcgt gaaggaagca gttcctctgg aagcttcttg     9540

aagacaaaca acgtctgtag cgaccctttg caggcagcgg aaccccccac ctggcgacag     9600

gtgcctctgc ggccaaaagc cacgtgtata agatacacct gcaaaggcgg cacaacccca     9660

gtgccacgtt gtgagttgga tagttgtgga aagagtcaaa tggctctcct caagcgtatt     9720

caacaagggg ctgaaggatg cccagaaggt accccattgt atgggatctg atctggggcc     9780

tcggtacaca tgctttacat gtgtttagtc gaggttaaaa aaacgtctag gccccccgaa     9840

ccacggggac gtggttttcc tttgaaaaac acgatgataa tatggccaca accttggatg     9900

accgagtaca agcccacggt gcgcctcgcc acccgcgacg acgtcccccg ggccgtacgc     9960

accctcgccg ccgcgttcgc cgactacccc gccacgcgcc acaccgtcga cccggaccgc    10020

cacatcgagc gggtcaccga gctgcaagaa ctcttcctca cgcgcgtcgg gctcgacatc    10080

ggcaaggtgt gggtcgcgga cgacggcgcc gcggtggcgg tctggaccac gccggagagc    10140

gtcgaagcgg gggcggtgtt cgccgagatc ggcccgcgca tggccgagtt gagcggttcc    10200

cggctggccg cgcagcaaca gatggaaggc ctcctggcgc cgcaccggcc caaggagccc    10260

gcgtggttcc tggccaccgt cggcgtctcg cccgaccacc agggcaaggg tctgggcagc    10320

gccgtcgtgc tccccggagt ggaggcggcc gagcgcgccg gggtgcccgc cttcctggag    10380

acctccgcgc cccgcaacct ccccttctac gagcggctcg gcttcaccgt caccgccgac    10440

gtcgaggtgc ccgaaggacc gcgcacctgg tgcatgaccc gcaagcccgg tgcctgataa    10500

ggtaccttta agaccaatga cttacaaggc agctgtagat cttagccact ttttaaaaga    10560

aaagggggga ctggaagggc taattcactc ccaacgaaga caagatcttt ttgcttgtac    10620

tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc    10680

actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt    10740

gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag    10800

a                                                                    10801


<210>  38
<211>  6
<212>  DNA
<213>  Bacillus amyloliquefaciens


<220>
<221>  misc_feature
<223>  Site de restriction BamHI

<400>  38
ggatcc                                                                   6


<210>  39
<211>  81
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(81)
<223>  Peptide d'initiation de transfert (PIT) de la protine E1 du 
       virus HCV de gnotype 4a

<400>  39
atg aca ggg aat ctt cct ggt tgc tct ttt tct atc ttc ctt ttg gca         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ctt ctc tcg tgc ctg act gtc ccc gct tcg gcc                             81
Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala                               
            20                  25                                        


<210>  40
<211>  27
<212>  PRT
<213>  Hepatitis C virus

<400>  40

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 
            20                  25          


<210>  41
<211>  57
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(57)
<223>  Peptide d'initiation de transfert (PIT) de la protine E2 du 
       virus HCV de gnotype 4a

<400>  41
atg gct aat tgg gcc aaa gtc atc ttg gtc cta ttc ctc ttc gca ggg         48
Met Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly           
1               5                   10                  15                

gtt gac gct                                                             57
Val Asp Ala                                                               
                                                                          


<210>  42
<211>  19
<212>  PRT
<213>  Hepatitis C virus

<400>  42

Met Ala Asn Trp Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly 
1               5                   10                  15      


Val Asp Ala 
            


<210>  43
<211>  57
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(57)
<223>  Peptide d'initiation de transfert (PIT) de la protine E2 du 
       virus HCV de gnotype 1a

<400>  43
atg ggg aac tgg gcg aag gtc ctg gtg gtg ctg ttg ctg ttc gcc agc         48
Met Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser           
1               5                   10                  15                

gtc gat gcg                                                             57
Val Asp Ala                                                               
                                                                          


<210>  44
<211>  19
<212>  PRT
<213>  Hepatitis C virus

<400>  44

Met Gly Asn Trp Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Ser 
1               5                   10                  15      


Val Asp Ala 
            


<210>  45
<211>  57
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(57)
<223>  Peptide d'initiation de transfert (PIT) de la protine E2 du 
       virus HCV de gnotype 3a

<400>  45
atg ggc aat tgg gcc aag gtc gct gtc atc atg act atg ttt tca ggg         48
Met Gly Asn Trp Ala Lys Val Ala Val Ile Met Thr Met Phe Ser Gly           
1               5                   10                  15                

gtc gat gcc                                                             57
Val Asp Ala                                                               
                                                                          


<210>  46
<211>  19
<212>  PRT
<213>  Hepatitis C virus

<400>  46

Met Gly Asn Trp Ala Lys Val Ala Val Ile Met Thr Met Phe Ser Gly 
1               5                   10                  15      


Val Asp Ala 
            


<210>  47
<211>  81
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(81)
<223>  Peptide d'initiation de transfert (PIT) de la protine E1 du 
       virus HCV de gnotype 1a

<400>  47
atg aca ggg aac ctt cct ggt tgc tct ttc tct atc ttc ctt ctg gcc         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ctg ctc tct tgc ctg act gtg ccc gcg tca gcc                             81
Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala                               
            20                  25                                        


<210>  48
<211>  27
<212>  PRT
<213>  Hepatitis C virus

<400>  48

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 
            20                  25          


<210>  49
<211>  81
<212>  DNA
<213>  Hepatitis C virus


<220>
<221>  CDS
<222>  (1)..(81)
<223>  Peptide d'initiation de transfert (PIT) de la protine E1 du 
       virus HCV de gnotype 3a

<400>  49
atg aca ggg aac ttg ccc ggt tgc tcc ttt tct atc ttc ctc ctc gct         48
Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala           
1               5                   10                  15                

ttg ctc tct tgc tta atc cat cca gca gct agt                             81
Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser                               
            20                  25                                        


<210>  50
<211>  27
<212>  PRT
<213>  Hepatitis C virus

<400>  50

Met Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 
1               5                   10                  15      


Leu Leu Ser Cys Leu Ile His Pro Ala Ala Ser 
            20                  25          


<210>  51
<211>  3011
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<223>  Polyprotine du virus HCV de gnotype 1a

<400>  51

Met Ser Thr Asn Pro Lys Pro Gln Lys Lys Asn Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 
            180                 185                 190         


Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Ala Thr 
                245                 250                 255     


Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 
        275                 280                 285             


Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Gly Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Met Ala Gln 
                325                 330                 335     


Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 
            340                 345                 350         


Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Thr Gly Gly Ser Ala Gly His Thr Val Ser Gly Phe Val 
385                 390                 395                 400 


Ser Leu Leu Ala Pro Gly Ala Lys Gln Asn Val Gln Leu Ile Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Leu Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr His His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro Leu Thr Asp 
    450                 455                 460                 


Phe Asp Gln Gly Trp Gly Pro Ile Ser Tyr Ala Asn Gly Ser Gly Pro 
465                 470                 475                 480 


Asp Gln Arg Pro Tyr Cys Trp His Tyr Pro Pro Lys Pro Cys Gly Ile 
                485                 490                 495     


Val Pro Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 
            500                 505                 510         


Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 
        515                 520                 525             


Trp Gly Glu Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg Pro 
    530                 535                 540                 


Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser Thr Gly Phe 
545                 550                 555                 560 


Thr Lys Val Cys Gly Ala Pro Pro Cys Val Ile Gly Gly Ala Gly Asn 
                565                 570                 575     


Asn Thr Leu His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Asp Ala 
            580                 585                 590         


Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 
    610                 615                 620                 


Thr Ile Phe Lys Ile Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 
625                 630                 635                 640 


Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp 
                645                 650                 655     


Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Gln Trp 
            660                 665                 670         


Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Leu Phe Leu Leu Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 
                725                 730                 735     


Met Met Leu Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 
            740                 745                 750         


Ile Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 
        755                 760                 765             


Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Lys Trp Val Pro 
    770                 775                 780                 


Gly Ala Val Tyr Thr Phe Tyr Gly Met Trp Pro Leu Leu Leu Leu Leu 
785                 790                 795                 800 


Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp Thr Glu Val Ala Ala 
                805                 810                 815     


Ser Cys Gly Gly Val Val Leu Val Gly Leu Met Ala Leu Thr Leu Ser 
            820                 825                 830         


Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp Cys Leu Trp Trp Leu Gln Tyr 
        835                 840                 845             


Phe Leu Thr Arg Val Glu Ala Gln Leu His Val Trp Ile Pro Pro Leu 
    850                 855                 860                 


Asn Val Arg Gly Gly Arg Asp Ala Val Ile Leu Leu Met Cys Ala Val 
865                 870                 875                 880 


His Pro Thr Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Val Phe 
                885                 890                 895     


Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr Phe 
            900                 905                 910         


Val Arg Val Gln Gly Leu Leu Arg Phe Cys Ala Leu Ala Arg Lys Met 
        915                 920                 925             


Ile Gly Gly His Tyr Val Gln Met Val Ile Ile Lys Leu Gly Ala Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Val Tyr Asn His Leu Thr Pro Leu Arg Asp Trp Ala 
945                 950                 955                 960 


His Asn Gly Leu Arg Asp Leu Ala Val Ala Val Glu Pro Val Val Phe 
                965                 970                 975     


Ser Gln Met Glu Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Asn Gly Leu  Pro Val Ser Ala Arg  Arg Gly Arg 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Gly Met Val Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Leu  Gly Cys Ile Ile Thr  Ser Leu Thr Gly Arg  Asp Lys Asn 
    1040                 1045                 1050             


Gln Val  Glu Gly Glu Val Gln  Ile Val Ser Thr Ala  Ala Gln Thr 
    1055                 1060                 1065             


Phe Leu  Ala Thr Cys Ile Asn  Gly Val Cys Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Thr Arg Thr Ile  Ala Ser Pro Lys Gly  Pro Val Ile 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Gln  Gly Ser Arg Ser Leu  Thr Pro Cys Thr Cys  Gly Ser Ser 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Ser Arg Gly  Ser Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Tyr  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Ala 
    1160                 1165                 1170             


Gly His  Ala Val Gly Ile Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Ile Pro Val Glu Asn  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Ser  Pro Pro Val 
    1205                 1210                 1215             


Val Pro  Gln Ser Phe Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala Tyr Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Ala Tyr Met Ser Lys  Ala His Gly Ile Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Thr  Gly Val Arg Thr Ile  Thr Thr Gly Ser Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys His Ser  Thr Asp Ala 
    1310                 1315                 1320             


Thr Ser  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Ala Arg Leu Val Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Val Pro His Pro  Asn Ile Glu Glu Val  Ala Leu Ser 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Val Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Ala  Lys Leu Val Ala Leu  Gly Ile Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Val  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Tyr Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Cys Val 
    1445                 1450                 1455             


Thr Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Thr Ile Glu 
    1460                 1465                 1470             


Thr Ile  Thr Leu Pro Gln Asp  Ala Val Ser Arg Thr  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Lys  Pro Gly Ile Tyr Arg  Phe Val Ala 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Ser Ser  Val Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Val Arg Leu Arg  Ala Tyr Met Asn Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Gly  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Ala  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Leu Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Cys Ala  Arg Ala Gln Ala Pro  Pro Pro Ser Trp Asp  Gln Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ala  Val Gln Asn Glu Ile  Thr Leu Thr 
    1625                 1630                 1635             


His Pro  Val Thr Lys Tyr Ile  Met Thr Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Thr Gly Cys Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Val Val Leu Ser Gly  Lys Pro Ala Ile Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Arg Glu Phe  Asp Glu Met Glu Glu  Cys Ser Gln 
    1700                 1705                 1710             


His Leu  Pro Tyr Ile Glu Gln  Gly Met Met Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Gln Thr Ala Ser  Arg Gln Ala 
    1730                 1735                 1740             


Glu Val  Ile Ala Pro Ala Val  Gln Thr Asn Trp Gln  Lys Leu Glu 
    1745                 1750                 1755             


Thr Phe  Trp Ala Lys His Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ala Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Ser Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ala 
    1805                 1810                 1815             


Gln Leu  Ala Ala Pro Gly Ala  Ala Thr Ala Phe Val  Gly Ala Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Ile Gly  Ser Val Gly Leu Gly  Lys Val Leu 
    1835                 1840                 1845             


Ile Asp  Ile Leu Ala Gly Tyr  Gly Ala Gly Val Ala  Gly Ala Leu 
    1850                 1855                 1860             


Val Ala  Phe Lys Ile Met Ser  Gly Glu Val Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Gly  Val Val Cys Ala Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Ala Arg Val Thr  Ala Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Gln  Leu Leu Arg Arg Leu  His Gln Trp Ile Ser  Ser Glu Cys 
    1955                 1960                 1965             


Thr Thr  Pro Cys Ser Gly Ser  Trp Leu Arg Asp Ile  Trp Asp Trp 
    1970                 1975                 1980             


Ile Cys  Glu Val Leu Ser Asp  Phe Lys Thr Trp Leu  Lys Ala Lys 
    1985                 1990                 1995             


Leu Met  Pro Gln Leu Pro Gly  Ile Pro Phe Val Ser  Cys Gln Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Val Trp Arg  Val Asp Gly Ile Met  His Thr Arg 
    2015                 2020                 2025             


Cys His  Cys Gly Ala Glu Ile  Thr Gly His Val Lys  Asn Gly Thr 
    2030                 2035                 2040             


Met Arg  Ile Val Gly Pro Arg  Thr Cys Arg Asn Met  Trp Ser Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Cys  Thr Pro Leu 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Thr Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Glu Tyr  Val Glu Ile Arg Gln  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Met  Thr Thr Asp Asn Leu  Lys Cys Pro Cys Gln  Val Pro Ser 
    2105                 2110                 2115             


Pro Glu  Phe Phe Thr Glu Leu  Asp Gly Val Arg Leu  His Arg Phe 
    2120                 2125                 2130             


Ala Pro  Pro Cys Lys Pro Leu  Leu Arg Glu Glu Val  Ser Phe Arg 
    2135                 2140                 2145             


Val Gly  Leu His Glu Tyr Pro  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ala  Ala Gly Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Pro  Pro Ser Val Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Ala 
    2195                 2200                 2205             


Pro Ser  Leu Lys Ala Thr Cys  Thr Ala Asn His Asp  Ser Pro Asp 
    2210                 2215                 2220             


Ala Glu  Leu Ile Glu Ala Asn  Leu Leu Trp Arg Gln  Glu Met Gly 
    2225                 2230                 2235             


Gly Asn  Ile Thr Arg Val Glu  Ser Glu Asn Lys Val  Val Ile Leu 
    2240                 2245                 2250             


Asp Ser  Phe Asp Pro Leu Val  Ala Glu Glu Asp Glu  Arg Glu Ile 
    2255                 2260                 2265             


Ser Val  Pro Ala Glu Ile Leu  Arg Lys Ser Arg Arg  Phe Ala Gln 
    2270                 2275                 2280             


Ala Leu  Pro Val Trp Ala Arg  Pro Asp Tyr Asn Pro  Pro Leu Val 
    2285                 2290                 2295             


Glu Thr  Trp Lys Lys Pro Asp  Tyr Glu Pro Pro Val  Val His Gly 
    2300                 2305                 2310             


Cys Pro  Leu Pro Pro Pro Lys  Ser Pro Pro Val Pro  Pro Pro Arg 
    2315                 2320                 2325             


Lys Lys  Arg Thr Val Val Leu  Thr Glu Ser Thr Leu  Ser Thr Ala 
    2330                 2335                 2340             


Leu Ala  Glu Leu Ala Thr Arg  Ser Phe Gly Ser Ser  Ser Thr Ser 
    2345                 2350                 2355             


Gly Ile  Thr Gly Asp Asn Thr  Thr Thr Ser Ser Glu  Pro Ala Pro 
    2360                 2365                 2370             


Ser Gly  Cys Pro Pro Asp Ser  Asp Ala Glu Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Ser Asp Gly 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Ser  Glu Ala Asn Ala Glu  Asp Val Val 
    2405                 2410                 2415             


Cys Cys  Ser Met Ser Tyr Ser  Trp Thr Gly Ala Leu  Val Thr Pro 
    2420                 2425                 2430             


Cys Ala  Ala Glu Glu Gln Lys  Leu Pro Ile Asn Ala  Leu Ser Asn 
    2435                 2440                 2445             


Ser Leu  Leu Arg His His Asn  Leu Val Tyr Ser Thr  Thr Ser Arg 
    2450                 2455                 2460             


Ser Ala  Cys Gln Arg Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln 
    2465                 2470                 2475             


Val Leu  Asp Ser His Tyr Gln  Asp Val Leu Lys Glu  Val Lys Ala 
    2480                 2485                 2490             


Ala Ala  Ser Lys Val Lys Ala  Asn Leu Leu Ser Val  Glu Glu Ala 
    2495                 2500                 2505             


Cys Ser  Leu Thr Pro Pro His  Ser Ala Lys Ser Lys  Phe Gly Tyr 
    2510                 2515                 2520             


Gly Ala  Lys Asp Val Arg Cys  His Ala Arg Lys Ala  Val Thr His 
    2525                 2530                 2535             


Ile Asn  Ser Val Trp Lys Asp  Leu Leu Glu Asp Asn  Val Thr Pro 
    2540                 2545                 2550             


Ile Asp  Thr Thr Ile Met Ala  Lys Asn Glu Val Phe  Cys Val Gln 
    2555                 2560                 2565             


Pro Glu  Lys Gly Gly Arg Lys  Pro Ala Arg Leu Ile  Val Phe Pro 
    2570                 2575                 2580             


Asp Leu  Gly Val Arg Val Cys  Glu Lys Met Ala Leu  Tyr Asp Val 
    2585                 2590                 2595             


Val Thr  Lys Leu Pro Leu Ala  Val Met Gly Ser Ser  Tyr Gly Phe 
    2600                 2605                 2610             


Gln Tyr  Ser Pro Gly Gln Arg  Val Glu Phe Leu Val  Gln Ala Trp 
    2615                 2620                 2625             


Lys Ser  Lys Lys Thr Pro Met  Gly Phe Ser Tyr Asp  Thr Arg Cys 
    2630                 2635                 2640             


Phe Asp  Ser Thr Val Thr Glu  Ser Asp Ile Arg Thr  Glu Glu Ala 
    2645                 2650                 2655             


Ile Tyr  Gln Cys Cys Asp Leu  Asp Pro Gln Ala Arg  Val Ala Ile 
    2660                 2665                 2670             


Lys Ser  Leu Thr Glu Arg Leu  Tyr Val Gly Gly Pro  Leu Thr Asn 
    2675                 2680                 2685             


Ser Arg  Gly Glu Asn Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly 
    2690                 2695                 2700             


Val Leu  Thr Thr Ser Cys Gly  Asn Thr Leu Thr Cys  Tyr Ile Lys 
    2705                 2710                 2715             


Ala Arg  Ala Ala Cys Arg Ala  Ala Gly Leu Gln Asp  Cys Thr Met 
    2720                 2725                 2730             


Leu Val  Cys Gly Asp Asp Leu  Val Val Ile Cys Glu  Ser Ala Gly 
    2735                 2740                 2745             


Val Gln  Glu Asp Ala Ala Ser  Leu Arg Ala Phe Thr  Glu Ala Met 
    2750                 2755                 2760             


Thr Arg  Tyr Ser Ala Pro Pro  Gly Asp Pro Pro Gln  Pro Glu Tyr 
    2765                 2770                 2775             


Asp Leu  Glu Leu Ile Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala 
    2780                 2785                 2790             


His Asp  Gly Ala Gly Lys Arg  Val Tyr Tyr Leu Thr  Arg Asp Pro 
    2795                 2800                 2805             


Thr Thr  Pro Leu Ala Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr 
    2810                 2815                 2820             


Pro Val  Asn Ser Trp Leu Gly  Asn Ile Ile Met Phe  Ala Pro Thr 
    2825                 2830                 2835             


Leu Trp  Ala Arg Met Ile Leu  Met Thr His Phe Phe  Ser Val Leu 
    2840                 2845                 2850             


Ile Ala  Arg Asp Gln Leu Glu  Gln Ala Leu Asp Cys  Glu Ile Tyr 
    2855                 2860                 2865             


Gly Ala  Cys Tyr Ser Ile Glu  Pro Leu Asp Leu Pro  Pro Ile Ile 
    2870                 2875                 2880             


Gln Arg  Leu His Gly Leu Ser  Ala Phe Ser Leu His  Ser Tyr Ser 
    2885                 2890                 2895             


Pro Gly  Glu Ile Asn Arg Val  Ala Ala Cys Leu Arg  Lys Leu Gly 
    2900                 2905                 2910             


Val Pro  Pro Leu Arg Ala Trp  Arg His Arg Ala Arg  Ser Val Arg 
    2915                 2920                 2925             


Ala Arg  Leu Leu Ala Arg Gly  Gly Arg Ala Ala Ile  Cys Gly Lys 
    2930                 2935                 2940             


Tyr Leu  Phe Asn Trp Ala Val  Arg Thr Lys Leu Lys  Leu Thr Pro 
    2945                 2950                 2955             


Ile Ala  Ala Ala Gly Gln Leu  Asp Leu Ser Gly Trp  Phe Thr Ala 
    2960                 2965                 2970             


Gly Tyr  Ser Gly Gly Asp Ile  Tyr His Ser Val Ser  His Ala Arg 
    2975                 2980                 2985             


Pro Arg  Trp Ile Trp Phe Cys  Leu Leu Leu Leu Ala  Ala Gly Val 
    2990                 2995                 3000             


Gly Ile  Tyr Leu Leu Pro Asn  Arg 
    3005                 3010     


<210>  52
<211>  3021
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<223>  Polyprotine du virus HCV de gnotype 3a

<400>  52

Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser Leu 
            180                 185                 190         


Glu Trp Arg Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr 
225                 230                 235                 240 


Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr Thr Ala 
                245                 250                 255     


Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala Thr Met Cys 
            260                 265                 270         


Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly 
        275                 280                 285             


Gln Ala Phe Thr Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys 
    290                 295                 300                 


Asn Cys Ser Leu Tyr Pro Gly His Leu Ser Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Ala Val Gly Met Val Val Ala His 
                325                 330                 335     


Val Leu Arg Leu Pro Gln Thr Leu Phe Asp Ile Met Ala Gly Ala His 
            340                 345                 350         


Trp Gly Ile Leu Ala Gly Leu Ala Tyr Tyr Ser Met Gln Gly Asn Trp 
        355                 360                 365             


Ala Lys Val Ala Ile Ile Met Val Met Phe Ser Gly Val Asp Ala His 
    370                 375                 380                 


Thr Tyr Thr Thr Gly Gly Thr Ala Ser Arg His Thr Gln Ala Phe Ala 
385                 390                 395                 400 


Gly Leu Phe Asp Ile Gly Pro Gln Gln Lys Leu Gln Leu Val Asn Thr 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 
            420                 425                 430         


Ile Asn Thr Gly Phe Ile Ala Gly Leu Phe Tyr Tyr His Lys Phe Asn 
        435                 440                 445             


Ser Thr Gly Cys Pro Gln Arg Leu Ser Ser Cys Lys Pro Ile Thr Phe 
    450                 455                 460                 


Phe Arg Gln Gly Trp Gly Pro Leu Thr Asp Ala Asn Ile Thr Gly Pro 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Asp 
                485                 490                 495     


Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp Ala Arg Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Lys Asp Val Phe Leu Leu Lys Ser Gln Arg 
    530                 535                 540                 


Pro Pro Ser Gly Arg Trp Phe Gly Cys Ser Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Leu Lys Thr Cys Gly Ala Pro Pro Cys Asn Ile Tyr Gly Gly Glu 
                565                 570                 575     


Gly Asn Pro His Asn Glu Ser Asp Leu Phe Cys Pro Thr Asp Cys Phe 
            580                 585                 590         


Arg Lys His Pro Glu Thr Thr Tyr Ser Arg Cys Gly Ala Gly Pro Trp 
        595                 600                 605             


Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 
    610                 615                 620                 


Pro Cys Thr Val Asp Phe Arg Leu Phe Lys Val Arg Met Phe Val Gly 
625                 630                 635                 640 


Gly Phe Glu His Arg Phe Thr Ala Ala Cys Asn Trp Thr Arg Gly Glu 
                645                 650                 655     


Arg Cys Asp Ile Glu Asp Arg Asp Arg Ser Glu Gln His Pro Leu Leu 
            660                 665                 670         


His Ser Thr Thr Glu Leu Ala Ile Leu Pro Cys Ser Phe Thr Pro Met 
        675                 680                 685             


Pro Ala Leu Ser Thr Gly Leu Ile His Leu His Gln Asn Ile Val Asp 
    690                 695                 700                 


Val Gln Tyr Leu Tyr Gly Val Gly Ser Gly Met Val Gly Trp Ala Leu 
705                 710                 715                 720 


Lys Trp Glu Phe Val Ile Leu Val Phe Leu Leu Leu Ala Asp Ala Arg 
                725                 730                 735     


Val Cys Val Ala Leu Trp Leu Met Leu Met Ile Ser Gln Thr Glu Ala 
            740                 745                 750         


Ala Leu Glu Asn Leu Val Thr Leu Asn Ala Val Ala Ala Ala Gly Thr 
        755                 760                 765             


His Gly Ile Gly Trp Tyr Leu Val Ala Phe Cys Ala Ala Trp Tyr Val 
    770                 775                 780                 


Arg Gly Lys Leu Val Pro Leu Val Thr Tyr Ser Leu Thr Gly Leu Trp 
785                 790                 795                 800 


Ser Leu Ala Leu Leu Val Leu Leu Leu Pro Gln Arg Ala Tyr Ala Trp 
                805                 810                 815     


Ser Gly Glu Asp Ser Ala Thr Leu Gly Ala Gly Val Leu Val Leu Phe 
            820                 825                 830         


Gly Phe Phe Thr Leu Ser Pro Trp Tyr Lys His Trp Ile Gly Arg Leu 
        835                 840                 845             


Met Trp Trp Asn Gln Tyr Thr Ile Cys Arg Cys Glu Ser Ala Leu His 
    850                 855                 860                 


Val Trp Val Pro Pro Leu Leu Ala Arg Gly Ser Arg Asp Gly Val Ile 
865                 870                 875                 880 


Leu Leu Thr Ser Leu Leu Tyr Pro Ser Leu Ile Phe Asp Ile Thr Lys 
                885                 890                 895     


Leu Leu Met Ala Val Leu Gly Pro Leu Tyr Leu Ile Gln Ala Thr Ile 
            900                 905                 910         


Thr Thr Thr Pro Tyr Phe Val Arg Ala His Val Leu Val Arg Leu Cys 
        915                 920                 925             


Met Leu Val Arg Ser Val Ile Gly Gly Lys Tyr Phe Gln Met Ile Ile 
    930                 935                 940                 


Leu Ser Ile Gly Arg Trp Phe Asn Thr Tyr Leu Tyr Asp His Leu Ala 
945                 950                 955                 960 


Pro Met Gln His Trp Ala Ala Ala Gly Leu Lys Asp Leu Ala Val Ala 
                965                 970                 975     


Thr Glu Pro Val Ile Phe Ser Pro Met Glu Ile Lys Val Ile Thr Trp 
            980                 985                 990         


Gly Ala Asp Thr Ala Ala Cys Gly  Asp Ile Leu Cys Gly  Leu Pro Val 
        995                 1000                 1005             


Ser Ala  Arg Leu Gly Arg Glu  Val Leu Leu Gly Pro  Ala Asp Asp 
    1010                 1015                 1020             


Tyr Arg  Glu Met Gly Trp Arg  Leu Leu Ala Pro Ile  Thr Ala Tyr 
    1025                 1030                 1035             


Ala Gln  Gln Thr Arg Gly Leu  Leu Gly Thr Ile Val  Thr Ser Leu 
    1040                 1045                 1050             


Thr Gly  Arg Asp Lys Asn Val  Val Thr Gly Glu Val  Gln Val Leu 
    1055                 1060                 1065             


Ser Thr  Ala Thr Gln Thr Phe  Leu Gly Thr Thr Val  Gly Gly Val 
    1070                 1075                 1080             


Ile Trp  Thr Val Tyr His Gly  Ala Gly Ser Arg Thr  Leu Ala Gly 
    1085                 1090                 1095             


Ala Lys  His Pro Ala Leu Gln  Met Tyr Thr Asn Val  Asp Gln Asp 
    1100                 1105                 1110             


Leu Val  Gly Trp Pro Ala Pro  Pro Gly Ala Lys Ser  Leu Glu Pro 
    1115                 1120                 1125             


Cys Ala  Cys Gly Ser Ser Asp  Leu Tyr Leu Val Thr  Arg Asp Ala 
    1130                 1135                 1140             


Asp Val  Ile Pro Ala Arg Arg  Arg Gly Asp Ser Thr  Ala Ser Leu 
    1145                 1150                 1155             


Leu Ser  Pro Arg Pro Leu Ala  Cys Leu Lys Gly Ser  Ser Gly Gly 
    1160                 1165                 1170             


Pro Val  Met Cys Pro Ser Gly  His Val Ala Gly Ile  Phe Arg Ala 
    1175                 1180                 1185             


Ala Val  Cys Thr Arg Gly Val  Ala Lys Ser Leu Gln  Phe Ile Pro 
    1190                 1195                 1200             


Val Glu  Thr Leu Ser Thr Gln  Ala Arg Ser Pro Ser  Phe Ser Asp 
    1205                 1210                 1215             


Asn Ser  Thr Pro Pro Ala Val  Pro Gln Ser Tyr Gln  Val Gly Tyr 
    1220                 1225                 1230             


Leu His  Ala Pro Thr Gly Ser  Gly Lys Ser Thr Lys  Val Pro Ala 
    1235                 1240                 1245             


Ala Tyr  Val Ala Gln Gly Tyr  Asn Val Leu Val Leu  Asn Pro Ser 
    1250                 1255                 1260             


Val Ala  Ala Thr Leu Gly Phe  Gly Ser Phe Met Ser  Arg Ala Tyr 
    1265                 1270                 1275             


Gly Ile  Asp Pro Asn Ile Arg  Thr Gly Asn Arg Thr  Val Thr Thr 
    1280                 1285                 1290             


Gly Ala  Lys Leu Thr Tyr Ser  Thr Tyr Gly Lys Phe  Leu Ala Asp 
    1295                 1300                 1305             


Gly Gly  Cys Ser Gly Gly Ala  Tyr Asp Val Ile Ile  Cys Asp Glu 
    1310                 1315                 1320             


Cys His  Ala Gln Asp Ala Thr  Ser Ile Leu Gly Ile  Gly Thr Val 
    1325                 1330                 1335             


Leu Asp  Gln Ala Glu Thr Ala  Gly Val Arg Leu Thr  Val Leu Ala 
    1340                 1345                 1350             


Thr Ala  Thr Pro Pro Gly Ser  Ile Thr Val Pro His  Ser Asn Ile 
    1355                 1360                 1365             


Glu Glu  Val Ala Leu Gly Ser  Glu Gly Glu Ile Pro  Phe Tyr Gly 
    1370                 1375                 1380             


Lys Ala  Ile Pro Ile Ala Leu  Leu Lys Gly Gly Arg  His Leu Ile 
    1385                 1390                 1395             


Phe Cys  His Ser Lys Lys Lys  Cys Asp Glu Ile Ala  Ser Lys Leu 
    1400                 1405                 1410             


Arg Gly  Met Gly Leu Asn Ala  Val Ala Tyr Tyr Arg  Gly Leu Asp 
    1415                 1420                 1425             


Val Ser  Val Ile Pro Thr Thr  Gly Asp Val Val Val  Cys Ala Thr 
    1430                 1435                 1440             


Asp Ala  Leu Met Thr Gly Phe  Thr Gly Asp Phe Asp  Ser Val Ile 
    1445                 1450                 1455             


Asp Cys  Asn Val Ala Val Glu  Gln Tyr Val Asp Phe  Ser Leu Asp 
    1460                 1465                 1470             


Pro Thr  Phe Ser Ile Glu Thr  Arg Thr Ala Pro Gln  Asp Ala Val 
    1475                 1480                 1485             


Ser Arg  Ser Gln Arg Arg Gly  Arg Thr Gly Arg Gly  Arg Leu Gly 
    1490                 1495                 1500             


Thr Tyr  Arg Tyr Val Ala Ser  Gly Glu Arg Pro Ser  Gly Met Phe 
    1505                 1510                 1515             


Asp Ser  Val Val Leu Cys Glu  Cys Tyr Asp Ala Gly  Cys Ser Trp 
    1520                 1525                 1530             


Tyr Asp  Leu Gln Pro Ala Glu  Thr Thr Val Arg Leu  Arg Ala Tyr 
    1535                 1540                 1545             


Leu Ser  Thr Pro Gly Leu Pro  Val Cys Gln Asp His  Leu Asp Phe 
    1550                 1555                 1560             


Trp Glu  Ser Val Phe Thr Gly  Leu Thr His Ile Asp  Ala His Phe 
    1565                 1570                 1575             


Leu Ser  Gln Thr Lys Gln Gln  Gly Leu Asn Phe Ser  Tyr Leu Thr 
    1580                 1585                 1590             


Ala Tyr  Gln Ala Thr Val Cys  Ala Arg Ala Gln Ala  Pro Pro Pro 
    1595                 1600                 1605             


Ser Trp  Asp Glu Met Trp Lys  Cys Leu Val Arg Leu  Lys Pro Thr 
    1610                 1615                 1620             


Leu His  Gly Pro Thr Pro Leu  Leu Tyr Arg Leu Gly  Pro Val Gln 
    1625                 1630                 1635             


Asn Glu  Thr Cys Leu Thr His  Pro Ile Thr Lys Tyr  Leu Met Ala 
    1640                 1645                 1650             


Cys Met  Ser Ala Asp Leu Glu  Val Thr Thr Ser Thr  Trp Val Leu 
    1655                 1660                 1665             


Leu Gly  Gly Val Leu Ala Ala  Leu Ala Ala Tyr Cys  Leu Ser Val 
    1670                 1675                 1680             


Gly Cys  Val Val Ile Val Gly  His Ile Glu Leu Glu  Gly Lys Pro 
    1685                 1690                 1695             


Ala Leu  Val Pro Asp Lys Glu  Val Leu Tyr Gln Gln  Tyr Asp Glu 
    1700                 1705                 1710             


Met Glu  Glu Cys Ser Gln Ala  Ala Pro Tyr Ile Glu  Gln Ala Gln 
    1715                 1720                 1725             


Val Ile  Ala His Gln Phe Lys  Glu Lys Ile Leu Gly  Leu Leu Gln 
    1730                 1735                 1740             


Arg Ala  Thr Gln Gln Gln Ala  Val Ile Glu Pro Ile  Val Thr Thr 
    1745                 1750                 1755             


Asn Trp  Gln Lys Leu Glu Ala  Phe Trp His Lys His  Met Trp Asn 
    1760                 1765                 1770             


Phe Val  Ser Gly Ile Gln Tyr  Leu Ala Gly Leu Ser  Thr Leu Pro 
    1775                 1780                 1785             


Gly Asn  Pro Ala Val Ala Ser  Leu Met Ala Phe Thr  Ala Ser Val 
    1790                 1795                 1800             


Thr Ser  Pro Leu Thr Thr Asn  Gln Thr Met Phe Phe  Asn Ile Leu 
    1805                 1810                 1815             


Gly Gly  Trp Val Ala Thr His  Leu Ala Gly Pro Gln  Ser Ser Ser 
    1820                 1825                 1830             


Ala Phe  Val Val Ser Gly Leu  Ala Gly Ala Ala Ile  Gly Gly Ile 
    1835                 1840                 1845             


Gly Leu  Gly Arg Val Leu Leu  Asp Ile Leu Ala Gly  Tyr Gly Ala 
    1850                 1855                 1860             


Gly Val  Ser Gly Ala Leu Val  Ala Phe Lys Ile Met  Gly Gly Glu 
    1865                 1870                 1875             


Cys Pro  Thr Ala Glu Asp Met  Val Asn Leu Leu Pro  Ala Ile Leu 
    1880                 1885                 1890             


Ser Pro  Gly Ala Leu Val Val  Gly Val Ile Cys Ala  Ala Ile Leu 
    1895                 1900                 1905             


Arg Arg  His Val Gly Pro Gly  Glu Gly Ala Val Gln  Trp Met Asn 
    1910                 1915                 1920             


Arg Leu  Ile Ala Phe Ala Ser  Arg Gly Asn His Val  Ser Pro Thr 
    1925                 1930                 1935             


His Tyr  Val Pro Glu Ser Asp  Ala Ala Ala Arg Val  Thr Ala Leu 
    1940                 1945                 1950             


Leu Ser  Ser Leu Thr Val Thr  Ser Leu Leu Arg Arg  Leu His Gln 
    1955                 1960                 1965             


Trp Ile  Asn Glu Asp Tyr Pro  Ser Pro Cys Ser Asp  Asp Trp Leu 
    1970                 1975                 1980             


Arg Thr  Ile Trp Asp Trp Val  Cys Ser Val Leu Ala  Asp Phe Lys 
    1985                 1990                 1995             


Ala Trp  Leu Ser Ala Lys Ile  Met Pro Ala Leu Pro  Gly Leu Pro 
    2000                 2005                 2010             


Phe Ile  Ser Cys Gln Lys Gly  Tyr Lys Gly Val Trp  Arg Gly Asp 
    2015                 2020                 2025             


Gly Val  Met Ser Thr Arg Cys  Pro Cys Gly Ala Ala  Ile Thr Gly 
    2030                 2035                 2040             


His Val  Lys Asn Gly Ser Met  Arg Leu Ala Gly Pro  Arg Thr Cys 
    2045                 2050                 2055             


Ala Asn  Met Trp His Gly Thr  Phe Pro Ile Asn Glu  Tyr Thr Thr 
    2060                 2065                 2070             


Gly Pro  Ser Thr Pro Cys Pro  Ser Pro Asn Tyr Thr  Arg Ala Leu 
    2075                 2080                 2085             


Trp Arg  Val Ala Ala Asn Ser  Tyr Val Glu Val Arg  Arg Val Gly 
    2090                 2095                 2100             


Asp Phe  His Tyr Ile Thr Gly  Ala Thr Glu Asp Glu  Leu Lys Cys 
    2105                 2110                 2115             


Pro Cys  Gln Val Pro Ala Ala  Glu Phe Phe Thr Glu  Val Asp Gly 
    2120                 2125                 2130             


Val Arg  Leu His Arg Tyr Ala  Pro Pro Cys Lys Pro  Leu Leu Arg 
    2135                 2140                 2145             


Asp Asp  Ile Thr Phe Met Val  Gly Leu His Ser Tyr  Thr Ile Gly 
    2150                 2155                 2160             


Ser Gln  Leu Pro Cys Glu Pro  Glu Pro Asp Val Ser  Val Leu Thr 
    2165                 2170                 2175             


Ser Met  Leu Arg Asp Pro Ser  His Ile Thr Ala Glu  Thr Ala Ala 
    2180                 2185                 2190             


Arg Arg  Leu Ala Arg Gly Ser  Pro Pro Ser Glu Ala  Ser Ser Ser 
    2195                 2200                 2205             


Ala Ser  Gln Leu Ser Ala Pro  Ser Leu Lys Ala Thr  Cys Gln Thr 
    2210                 2215                 2220             


His Arg  Pro His Pro Asp Ala  Glu Leu Val Asp Ala  Asn Leu Leu 
    2225                 2230                 2235             


Trp Arg  Gln Glu Met Gly Ser  Asn Ile Thr Arg Val  Glu Ser Glu 
    2240                 2245                 2250             


Thr Lys  Val Val Val Leu Asp  Ser Phe Glu Pro Leu  Arg Ala Glu 
    2255                 2260                 2265             


Thr Asp  Asp Val Glu Pro Ser  Val Ala Ala Glu Cys  Phe Lys Lys 
    2270                 2275                 2280             


Pro Pro  Lys Tyr Pro Pro Ala  Leu Pro Ile Trp Ala  Arg Pro Asp 
    2285                 2290                 2295             


Tyr Asn  Pro Pro Leu Leu Asp  Arg Trp Lys Ala Pro  Asp Tyr Val 
    2300                 2305                 2310             


Pro Pro  Thr Val His Gly Cys  Ala Leu Pro Pro Arg  Gly Ala Pro 
    2315                 2320                 2325             


Pro Val  Pro Pro Pro Arg Arg  Lys Arg Thr Ile Gln  Leu Asp Gly 
    2330                 2335                 2340             


Ser Asn  Val Ser Ala Ala Leu  Ala Ala Leu Ala Glu  Lys Ser Phe 
    2345                 2350                 2355             


Pro Ser  Ser Lys Pro Gln Glu  Glu Asn Ser Ser Ser  Ser Gly Val 
    2360                 2365                 2370             


Asp Thr  Gln Ser Ser Thr Thr  Ser Lys Val Pro Pro  Ser Pro Gly 
    2375                 2380                 2385             


Gly Glu  Ser Asp Ser Glu Ser  Cys Ser Ser Met Pro  Pro Leu Glu 
    2390                 2395                 2400             


Gly Glu  Pro Gly Asp Pro Asp  Leu Ser Cys Asp Ser  Trp Ser Thr 
    2405                 2410                 2415             


Val Ser  Asp Ser Glu Glu Gln  Ser Val Val Cys Cys  Ser Met Ser 
    2420                 2425                 2430             


Tyr Ser  Trp Thr Gly Ala Leu  Ile Thr Pro Cys Ser  Ala Glu Glu 
    2435                 2440                 2445             


Glu Lys  Leu Pro Ile Ser Pro  Leu Ser Asn Ser Leu  Leu Arg His 
    2450                 2455                 2460             


His Asn  Leu Val Tyr Ser Thr  Ser Ser Arg Ser Ala  Ser Gln Arg 
    2465                 2470                 2475             


Gln Lys  Lys Val Thr Phe Asp  Arg Leu Gln Val Leu  Asp Asp His 
    2480                 2485                 2490             


Tyr Lys  Thr Ala Leu Lys Glu  Val Lys Glu Arg Ala  Ser Arg Val 
    2495                 2500                 2505             


Lys Ala  Arg Met Leu Thr Ile  Glu Glu Ala Cys Ala  Leu Val Pro 
    2510                 2515                 2520             


Pro His  Ser Ala Arg Ser Lys  Phe Gly Tyr Ser Ala  Lys Asp Val 
    2525                 2530                 2535             


Arg Ser  Leu Ser Ser Arg Ala  Ile Asn Gln Ile Arg  Ser Val Trp 
    2540                 2545                 2550             


Glu Asp  Leu Leu Glu Asp Thr  Thr Thr Pro Ile Pro  Thr Thr Ile 
    2555                 2560                 2565             


Met Ala  Lys Asn Glu Val Phe  Cys Val Asp Pro Ala  Lys Gly Gly 
    2570                 2575                 2580             


Arg Lys  Pro Ala Arg Leu Ile  Val Tyr Pro Asp Leu  Gly Val Arg 
    2585                 2590                 2595             


Val Cys  Glu Lys Arg Ala Leu  Tyr Asp Val Ile Gln  Lys Leu Ser 
    2600                 2605                 2610             


Ile Glu  Thr Met Gly Pro Ala  Tyr Gly Phe Gln Tyr  Ser Pro Gln 
    2615                 2620                 2625             


Gln Arg  Val Glu Arg Leu Leu  Lys Met Trp Thr Ser  Lys Lys Thr 
    2630                 2635                 2640             


Pro Leu  Gly Phe Ser Tyr Asp  Thr Arg Cys Phe Asp  Ser Thr Val 
    2645                 2650                 2655             


Thr Glu  Gln Asp Ile Arg Val  Glu Glu Glu Ile Tyr  Gln Cys Cys 
    2660                 2665                 2670             


Asn Leu  Glu Pro Glu Ala Arg  Lys Val Ile Ser Ser  Leu Thr Glu 
    2675                 2680                 2685             


Arg Leu  Tyr Cys Gly Gly Pro  Met Phe Asn Ser Lys  Gly Ala Gln 
    2690                 2695                 2700             


Cys Gly  Tyr Arg Arg Cys Arg  Ala Ser Gly Val Leu  Pro Thr Ser 
    2705                 2710                 2715             


Phe Gly  Asn Thr Ile Thr Cys  Tyr Ile Lys Ala Thr  Ala Ala Ala 
    2720                 2725                 2730             


Lys Ala  Ala Asn Leu Arg Asn  Pro Asp Phe Leu Val  Cys Gly Asp 
    2735                 2740                 2745             


Asp Leu  Val Val Val Ala Glu  Ser Asp Gly Val Asp  Glu Asp Arg 
    2750                 2755                 2760             


Ala Ala  Leu Arg Ala Phe Thr  Glu Ala Met Thr Arg  Tyr Ser Ala 
    2765                 2770                 2775             


Pro Pro  Gly Asp Ala Pro Gln  Ala Thr Tyr Asp Leu  Glu Leu Ile 
    2780                 2785                 2790             


Thr Ser  Cys Ser Ser Asn Val  Ser Val Ala Arg Asp  Asp Lys Gly 
    2795                 2800                 2805             


Arg Arg  Tyr Tyr Tyr Leu Thr  Arg Asp Ala Thr Thr  Pro Leu Ala 
    2810                 2815                 2820             


Arg Ala  Ala Trp Glu Thr Ala  Arg His Thr Pro Val  Asn Ser Trp 
    2825                 2830                 2835             


Leu Gly  Asn Ile Ile Met Tyr  Ala Pro Thr Ile Trp  Val Arg Met 
    2840                 2845                 2850             


Val Met  Met Thr His Phe Phe  Ser Ile Leu Gln Ser  Gln Glu Ile 
    2855                 2860                 2865             


Leu Asp  Arg Pro Leu Asp Phe  Glu Met Tyr Gly Ala  Thr Tyr Ser 
    2870                 2875                 2880             


Val Thr  Pro Leu Asp Leu Pro  Ala Ile Ile Glu Arg  Leu His Gly 
    2885                 2890                 2895             


Leu Ser  Ala Phe Thr Leu His  Ser Tyr Ser Pro Val  Glu Leu Asn 
    2900                 2905                 2910             


Arg Val  Ala Gly Thr Leu Arg  Lys Leu Gly Cys Pro  Pro Leu Arg 
    2915                 2920                 2925             


Ala Trp  Arg His Arg Ala Arg  Ala Val Arg Ala Lys  Leu Ile Ala 
    2930                 2935                 2940             


Gln Gly  Gly Lys Ala Lys Ile  Cys Gly Leu Tyr Leu  Phe Asn Trp 
    2945                 2950                 2955             


Ala Val  Arg Thr Lys Thr Asn  Leu Thr Pro Leu Pro  Ala Ala Gly 
    2960                 2965                 2970             


Gln Leu  Asp Leu Ser Ser Trp  Phe Thr Val Gly Val  Gly Gly Asn 
    2975                 2980                 2985             


Asp Ile  Tyr His Ser Val Ser  Arg Ala Arg Thr Arg  His Leu Leu 
    2990                 2995                 3000             


Leu Cys  Leu Leu Leu Leu Thr  Val Gly Val Gly Ile  Phe Leu Leu 
    3005                 3010                 3015             


Pro Ala  Arg 
    3020     


<210>  53
<211>  3008
<212>  PRT
<213>  Hepatitis C virus


<220>
<221>  misc_feature
<223>  Polyprotine du virus HCV de gnotype 4a

<400>  53

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ser Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 
            100                 105                 110         


Arg Gly Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val 
    130                 135                 140                 


Gly Ser Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp 
145                 150                 155                 160 


Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Val 
            180                 185                 190         


Asn Tyr Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Pro 
        195                 200                 205             


Asn Ser Ser Ile Val Tyr Glu Ala Asp His His Ile Met His Leu Pro 
    210                 215                 220                 


Gly Cys Val Pro Cys Val Arg Glu Gly Asn Gln Ser Arg Cys Trp Val 
225                 230                 235                 240 


Ala Leu Thr Pro Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro Leu Glu 
                245                 250                 255     


Ser Leu Arg Ser His Val Asp Leu Met Val Gly Ala Ala Thr Val Cys 
            260                 265                 270         


Ser Gly Leu Tyr Ile Gly Asp Leu Cys Gly Gly Leu Phe Leu Val Gly 
        275                 280                 285             


Gln Met Phe Ser Phe Arg Pro Arg Arg His Trp Thr Thr Gln Asp Cys 
    290                 295                 300                 


Asn Cys Ser Ile Tyr Thr Gly His Ile Thr Gly His Arg Met Ala Trp 
305                 310                 315                 320 


Asp Met Met Met Asn Trp Ser Pro Thr Thr Thr Leu Val Leu Ala Gln 
                325                 330                 335     


Val Met Arg Ile Pro Thr Thr Leu Val Asp Leu Leu Ser Gly Gly His 
            340                 345                 350         


Trp Gly Val Leu Val Gly Val Ala Tyr Phe Ser Met Gln Ala Asn Trp 
        355                 360                 365             


Ala Lys Val Ile Leu Val Leu Phe Leu Phe Ala Gly Val Asp Ala Glu 
    370                 375                 380                 


Thr His Val Ser Gly Ala Ala Val Gly Arg Ser Thr Ala Gly Leu Ala 
385                 390                 395                 400 


Asn Leu Phe Ser Ser Gly Ser Lys Gln Asn Leu Gln Leu Ile Asn Ser 
                405                 410                 415     


Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 
            420                 425                 430         


Leu Asn Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His Lys Phe Asn 
        435                 440                 445             


Ser Ser Gly Cys Ser Glu Arg Leu Ala Cys Cys Lys Ser Leu Asp Ser 
    450                 455                 460                 


Tyr Gly Gln Gly Trp Gly Pro Leu Gly Val Ala Asn Ile Ser Gly Ser 
465                 470                 475                 480 


Ser Asp Asp Arg Pro Tyr Cys Trp His Tyr Ala Pro Arg Pro Cys Gly 
                485                 490                 495     


Ile Val Pro Ala Ser Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro 
            500                 505                 510         


Ser Pro Val Val Val Gly Thr Thr Asp His Val Gly Val Pro Thr Tyr 
        515                 520                 525             


Thr Trp Gly Glu Asn Glu Thr Asp Val Phe Leu Leu Asn Ser Thr Arg 
    530                 535                 540                 


Pro Pro His Gly Ala Trp Phe Gly Cys Val Trp Met Asn Ser Thr Gly 
545                 550                 555                 560 


Phe Thr Lys Thr Cys Gly Ala Pro Pro Cys Glu Val Asn Thr Asn Asn 
                565                 570                 575     


Gly Thr Trp His Cys Pro Thr Asp Cys Phe Arg Lys His Pro Glu Thr 
            580                 585                 590         


Thr Tyr Ala Lys Cys Gly Ser Gly Pro Trp Ile Thr Pro Arg Cys Leu 
        595                 600                 605             


Ile Asp Tyr Pro Tyr Arg Leu Trp His Phe Pro Cys Thr Ala Asn Phe 
    610                 615                 620                 


Ser Val Phe Asn Ile Arg Thr Phe Val Gly Gly Ile Glu His Arg Met 
625                 630                 635                 640 


Gln Ala Ala Cys Asn Trp Thr Arg Gly Glu Val Cys Gly Leu Glu His 
                645                 650                 655     


Arg Asp Arg Val Glu Leu Ser Pro Leu Leu Leu Thr Thr Thr Ala Trp 
            660                 665                 670         


Gln Ile Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala Leu Ser Thr Gly 
        675                 680                 685             


Leu Ile His Leu His Gln Asn Ile Val Asp Val Gln Tyr Leu Tyr Gly 
    690                 695                 700                 


Val Gly Ser Ala Val Val Ser Trp Ala Leu Lys Trp Glu Tyr Val Val 
705                 710                 715                 720 


Leu Ala Phe Leu Leu Leu Ala Asp Ala Arg Val Ser Ala Tyr Leu Trp 
                725                 730                 735     


Met Met Phe Met Val Ser Gln Val Glu Ala Ala Leu Ser Asn Leu Ile 
            740                 745                 750         


Asn Ile Asn Ala Ala Ser Ala Ala Gly Ala Gln Gly Phe Trp Tyr Ala 
        755                 760                 765             


Ile Leu Phe Ile Cys Ile Val Trp His Val Lys Gly Arg Phe Pro Ala 
    770                 775                 780                 


Ala Ala Ala Tyr Ala Ala Cys Gly Leu Trp Pro Cys Phe Leu Leu Leu 
785                 790                 795                 800 


Leu Met Leu Pro Glu Arg Ala Tyr Ala Tyr Asp Gln Glu Val Ala Gly 
                805                 810                 815     


Ser Leu Gly Gly Ala Ile Val Val Met Leu Thr Ile Leu Thr Leu Ser 
            820                 825                 830         


Pro His Tyr Lys Leu Trp Leu Ala Arg Gly Leu Trp Trp Ile Gln Tyr 
        835                 840                 845             


Phe Ile Ala Arg Thr Glu Ala Val Leu His Val Tyr Ile Pro Ser Phe 
    850                 855                 860                 


Asn Val Arg Gly Pro Arg Asp Ser Val Ile Val Leu Ala Val Leu Val 
865                 870                 875                 880 


Cys Pro Asp Leu Val Phe Asp Ile Thr Lys Tyr Leu Leu Ala Ile Leu 
                885                 890                 895     


Gly Pro Leu His Ile Leu Gln Ala Ser Leu Leu Arg Ile Pro Tyr Phe 
            900                 905                 910         


Val Arg Ala Gln Ala Leu Val Lys Ile Cys Ser Leu Leu Arg Gly Val 
        915                 920                 925             


Val Tyr Gly Lys Tyr Phe Gln Met Val Val Leu Lys Ser Arg Gly Leu 
    930                 935                 940                 


Thr Gly Thr Tyr Ile Tyr Asp His Leu Thr Pro Met Ser Asp Trp Pro 
945                 950                 955                 960 


Pro Tyr Gly Leu Arg Asp Leu Ala Val Ala Leu Glu Pro Val Val Phe 
                965                 970                 975     


Thr Pro Met Glu Lys Lys Val Ile Val Trp Gly Ala Asp Thr Ala Ala 
            980                 985                 990         


Cys Gly Asp Ile Ile Arg Gly Leu  Pro Val Ser Ala Arg  Leu Gly Asn 
        995                 1000                 1005             


Glu Ile  Leu Leu Gly Pro Ala  Asp Thr Glu Thr Ser  Lys Gly Trp 
    1010                 1015                 1020             


Arg Leu  Leu Ala Pro Ile Thr  Ala Tyr Ala Gln Gln  Thr Arg Gly 
    1025                 1030                 1035             


Leu Phe  Ser Thr Ile Val Thr  Ser Leu Thr Gly Arg  Asp Thr Asn 
    1040                 1045                 1050             


Glu Asn  Cys Gly Glu Val Gln  Val Leu Ser Thr Ala  Thr Gln Ser 
    1055                 1060                 1065             


Phe Leu  Gly Thr Ala Val Asn  Gly Val Met Trp Thr  Val Tyr His 
    1070                 1075                 1080             


Gly Ala  Gly Ala Lys Thr Ile  Ser Gly Pro Lys Gly  Pro Val Asn 
    1085                 1090                 1095             


Gln Met  Tyr Thr Asn Val Asp  Gln Asp Leu Val Gly  Trp Pro Ala 
    1100                 1105                 1110             


Pro Pro  Gly Val Arg Ser Leu  Ala Pro Cys Thr Cys  Gly Ser Ala 
    1115                 1120                 1125             


Asp Leu  Tyr Leu Val Thr Arg  His Ala Asp Val Ile  Pro Val Arg 
    1130                 1135                 1140             


Arg Arg  Gly Asp Thr Arg Gly  Ala Leu Leu Ser Pro  Arg Pro Ile 
    1145                 1150                 1155             


Ser Ile  Leu Lys Gly Ser Ser  Gly Gly Pro Leu Leu  Cys Pro Met 
    1160                 1165                 1170             


Gly His  Arg Ala Gly Ile Phe  Arg Ala Ala Val Cys  Thr Arg Gly 
    1175                 1180                 1185             


Val Ala  Lys Ala Val Asp Phe  Val Pro Val Glu Ser  Leu Glu Thr 
    1190                 1195                 1200             


Thr Met  Arg Ser Pro Val Phe  Thr Asp Asn Ser Thr  Pro Pro Ala 
    1205                 1210                 1215             


Val Pro  Gln Thr Tyr Gln Val  Ala His Leu His Ala  Pro Thr Gly 
    1220                 1225                 1230             


Ser Gly  Lys Ser Thr Lys Val  Pro Ala Ala His Ala  Ala Gln Gly 
    1235                 1240                 1245             


Tyr Lys  Val Leu Val Leu Asn  Pro Ser Val Ala Ala  Thr Leu Gly 
    1250                 1255                 1260             


Phe Gly  Val Tyr Met Ser Lys  Ala Tyr Gly Ile Asp  Pro Asn Ile 
    1265                 1270                 1275             


Arg Ser  Gly Val Arg Thr Ile  Thr Thr Gly Ala Pro  Ile Thr Tyr 
    1280                 1285                 1290             


Ser Thr  Tyr Gly Lys Phe Leu  Ala Asp Gly Gly Cys  Ser Gly Gly 
    1295                 1300                 1305             


Ala Tyr  Asp Ile Ile Ile Cys  Asp Glu Cys Tyr Ser  Thr Asp Ser 
    1310                 1315                 1320             


Thr Thr  Ile Leu Gly Ile Gly  Thr Val Leu Asp Gln  Ala Glu Thr 
    1325                 1330                 1335             


Ala Gly  Val Arg Leu Thr Val  Leu Ala Thr Ala Thr  Pro Pro Gly 
    1340                 1345                 1350             


Ser Val  Thr Thr Pro His Ser  Asn Ile Glu Glu Val  Ala Leu Pro 
    1355                 1360                 1365             


Thr Thr  Gly Glu Ile Pro Phe  Tyr Gly Lys Ala Ile  Pro Leu Glu 
    1370                 1375                 1380             


Leu Ile  Lys Gly Gly Arg His  Leu Ile Phe Cys His  Ser Lys Lys 
    1385                 1390                 1395             


Lys Cys  Asp Glu Leu Ala Arg  Gln Leu Thr Ser Leu  Gly Leu Asn 
    1400                 1405                 1410             


Ala Val  Ala Tyr Tyr Arg Gly  Leu Asp Val Ser Val  Ile Pro Thr 
    1415                 1420                 1425             


Ser Gly  Asp Val Val Val Cys  Ala Thr Asp Ala Leu  Met Thr Gly 
    1430                 1435                 1440             


Phe Thr  Gly Asp Phe Asp Ser  Val Ile Asp Cys Asn  Thr Ser Val 
    1445                 1450                 1455             


Ile Gln  Thr Val Asp Phe Ser  Leu Asp Pro Thr Phe  Ser Ile Glu 
    1460                 1465                 1470             


Ile Thr  Thr Val Pro Gln Asp  Ala Val Ser Arg Ser  Gln Arg Arg 
    1475                 1480                 1485             


Gly Arg  Thr Gly Arg Gly Arg  Leu Gly Thr Tyr Arg  Tyr Val Thr 
    1490                 1495                 1500             


Pro Gly  Glu Arg Pro Ser Gly  Met Phe Asp Thr Ala  Glu Leu Cys 
    1505                 1510                 1515             


Glu Cys  Tyr Asp Ala Gly Cys  Ala Trp Tyr Glu Leu  Thr Pro Ala 
    1520                 1525                 1530             


Glu Thr  Thr Thr Arg Leu Lys  Ala Tyr Phe Asp Thr  Pro Gly Leu 
    1535                 1540                 1545             


Pro Val  Cys Gln Asp His Leu  Glu Phe Trp Glu Ser  Val Phe Thr 
    1550                 1555                 1560             


Gly Leu  Thr His Ile Asp Gly  His Phe Leu Ser Gln  Thr Lys Gln 
    1565                 1570                 1575             


Ser Gly  Glu Asn Phe Pro Tyr  Leu Val Ala Tyr Gln  Ala Thr Val 
    1580                 1585                 1590             


Ser Ala  Lys Val Trp Leu Ala  Pro Pro Ser Trp Asp  Thr Met Trp 
    1595                 1600                 1605             


Lys Cys  Leu Ile Arg Leu Lys  Pro Thr Leu His Gly  Pro Thr Pro 
    1610                 1615                 1620             


Leu Leu  Tyr Arg Leu Gly Ser  Val Gln Asn Glu Val  Val Leu Thr 
    1625                 1630                 1635             


His Pro  Ile Thr Lys Tyr Ile  Met Ala Cys Met Ser  Ala Asp Leu 
    1640                 1645                 1650             


Glu Val  Val Thr Ser Thr Trp  Val Leu Val Gly Gly  Val Leu Ala 
    1655                 1660                 1665             


Ala Leu  Ala Ala Tyr Cys Leu  Ser Val Gly Ser Val  Val Ile Val 
    1670                 1675                 1680             


Gly Arg  Val Val Leu Ser Gly  Gln Pro Ala Val Ile  Pro Asp Arg 
    1685                 1690                 1695             


Glu Val  Leu Tyr Gln Gln Phe  Asp Glu Met Glu Glu  Cys Ser Lys 
    1700                 1705                 1710             


His Leu  Pro Leu Val Glu His  Gly Leu Gln Leu Ala  Glu Gln Phe 
    1715                 1720                 1725             


Lys Gln  Lys Ala Leu Gly Leu  Leu Asn Phe Ala Gly  Lys Gln Ala 
    1730                 1735                 1740             


Gln Glu  Ala Thr Pro Val Ile  Gln Ser Asn Phe Ala  Lys Leu Glu 
    1745                 1750                 1755             


Gln Phe  Trp Ala Asn Asp Met  Trp Asn Phe Ile Ser  Gly Ile Gln 
    1760                 1765                 1770             


Tyr Leu  Ala Gly Leu Ser Thr  Leu Pro Gly Asn Pro  Ala Ile Ala 
    1775                 1780                 1785             


Ser Leu  Met Ser Phe Thr Ala  Ala Val Thr Ser Pro  Leu Thr Thr 
    1790                 1795                 1800             


Gln Gln  Thr Leu Leu Phe Asn  Ile Leu Gly Gly Trp  Val Ala Ser 
    1805                 1810                 1815             


Gln Ile  Arg Asp Ser Asp Ala  Ser Thr Ala Phe Val  Val Ser Gly 
    1820                 1825                 1830             


Leu Ala  Gly Ala Ala Val Gly  Ser Val Gly Leu Gly  Lys Ile Leu 
    1835                 1840                 1845             


Val Asp  Ile Leu Pro Gly Tyr  Gly Ala Gly Val Arg  Gly Ala Val 
    1850                 1855                 1860             


Val Thr  Phe Lys Ile Met Ser  Gly Glu Met Pro Ser  Thr Glu Asp 
    1865                 1870                 1875             


Leu Val  Asn Leu Leu Pro Ala  Ile Leu Ser Pro Gly  Ala Leu Val 
    1880                 1885                 1890             


Val Glu  Val Val Cys Pro Ala  Ile Leu Arg Arg His  Val Gly Pro 
    1895                 1900                 1905             


Gly Glu  Gly Ala Val Gln Trp  Met Asn Arg Leu Ile  Ala Phe Ala 
    1910                 1915                 1920             


Ser Arg  Gly Asn His Val Ser  Pro Thr His Tyr Val  Pro Glu Ser 
    1925                 1930                 1935             


Asp Ala  Ala Arg Arg Val Thr  Thr Ile Leu Ser Ser  Leu Thr Val 
    1940                 1945                 1950             


Thr Ser  Leu Leu Arg Arg Leu  His Lys Trp Ile Asn  Glu Asp Cys 
    1955                 1960                 1965             


Ser Thr  Pro Cys Ala Glu Ser  Trp Leu Trp Glu Val  Trp Asp Trp 
    1970                 1975                 1980             


Val Leu  His Val Leu Ser Asp  Phe Lys Thr Cys Leu  Lys Ala Lys 
    1985                 1990                 1995             


Phe Val  Pro Leu Met Pro Gly  Ile Pro Leu Leu Ser  Trp Pro Arg 
    2000                 2005                 2010             


Gly Tyr  Lys Gly Glu Trp Arg  Gly Asp Gly Val Met  His Thr Thr 
    2015                 2020                 2025             


Cys Pro  Cys Gly Ala Asp Leu  Ala Gly His Ile Lys  Asn Gly Ser 
    2030                 2035                 2040             


Met Arg  Ile Thr Gly Pro Lys  Thr Cys Ser Asn Thr  Trp His Gly 
    2045                 2050                 2055             


Thr Phe  Pro Ile Asn Ala Tyr  Thr Thr Gly Pro Gly  Val Pro Ile 
    2060                 2065                 2070             


Pro Ala  Pro Asn Tyr Lys Phe  Ala Leu Trp Arg Val  Ser Ala Glu 
    2075                 2080                 2085             


Asp Tyr  Val Glu Val Arg Arg  Val Gly Asp Phe His  Tyr Val Thr 
    2090                 2095                 2100             


Gly Val  Thr Gln Asp Asn Ile  Lys Phe Pro Cys Gln  Val Pro Ala 
    2105                 2110                 2115             


Pro Glu  Leu Phe Thr Glu Val  Asp Gly Ile Arg Ile  His Arg His 
    2120                 2125                 2130             


Ala Pro  Lys Cys Lys Pro Leu  Leu Arg Asp Glu Val  Ser Phe Ser 
    2135                 2140                 2145             


Val Gly  Leu Asn Ser Phe Val  Val Gly Ser Gln Leu  Pro Cys Glu 
    2150                 2155                 2160             


Pro Glu  Pro Asp Val Ala Val  Leu Thr Ser Met Leu  Thr Asp Pro 
    2165                 2170                 2175             


Ser His  Ile Thr Ala Glu Ser  Ala Arg Arg Arg Leu  Ala Arg Gly 
    2180                 2185                 2190             


Ser Arg  Pro Ser Leu Ala Ser  Ser Ser Ala Ser Gln  Leu Ser Pro 
    2195                 2200                 2205             


Arg Leu  Leu Gln Ala Thr Cys  Thr Ala Pro His Asp  Ser Pro Gly 
    2210                 2215                 2220             


Thr Asp  Leu Leu Glu Ala Asn  Leu Leu Trp Gly Ser  Thr Ala Thr 
    2225                 2230                 2235             


Arg Val  Glu Thr Asp Glu Lys  Val Ile Ile Leu Asp  Ser Phe Glu 
    2240                 2245                 2250             


Ser Cys  Val Ala Glu Gln Asn  Asp Asp Arg Glu Val  Ser Val Ala 
    2255                 2260                 2265             


Ala Glu  Ile Leu Arg Pro Thr  Lys Lys Phe Pro Pro  Ala Leu Pro 
    2270                 2275                 2280             


Ile Trp  Ala Arg Pro Asp Tyr  Asn Pro Pro Leu Thr  Glu Thr Trp 
    2285                 2290                 2295             


Lys Gln  Gln Asp Tyr Gln Ala  Pro Thr Val His Gly  Cys Ala Leu 
    2300                 2305                 2310             


Pro Pro  Ala Lys Gln Pro Pro  Val Pro Ser Pro Arg  Arg Lys Arg 
    2315                 2320                 2325             


Thr Val  Gln Leu Thr Glu Ser  Val Val Ser Thr Ala  Leu Ala Glu 
    2330                 2335                 2340             


Leu Ala  Ala Lys Thr Phe Gly  Gln Ser Glu Pro Ser  Ser Asp Arg 
    2345                 2350                 2355             


Asp Thr  Asp Leu Thr Thr Pro  Thr Glu Thr Thr Asp  Ser Gly Pro 
    2360                 2365                 2370             


Ile Val  Val Asp Asp Ala Ser  Asp Asp Gly Ser Tyr  Ser Ser Met 
    2375                 2380                 2385             


Pro Pro  Leu Glu Gly Glu Pro  Gly Asp Pro Asp Leu  Thr Ser Asp 
    2390                 2395                 2400             


Ser Trp  Ser Thr Val Ser Gly  Ser Glu Asp Val Val  Cys Cys Ser 
    2405                 2410                 2415             


Met Ser  Tyr Ser Trp Thr Gly  Ala Leu Val Thr Pro  Cys Ala Ala 
    2420                 2425                 2430             


Glu Glu  Ser Lys Leu Pro Ile  Ser Pro Leu Ser Asn  Ser Leu Leu 
    2435                 2440                 2445             


Arg His  His Asn Met Val Tyr  Ala Thr Thr Thr Arg  Ser Ala Val 
    2450                 2455                 2460             


Thr Arg  Gln Lys Lys Val Thr  Phe Asp Arg Leu Gln  Val Val Asp 
    2465                 2470                 2475             


Ser Thr  Tyr Asn Glu Val Leu  Lys Glu Ile Lys Ala  Arg Ala Ser 
    2480                 2485                 2490             


Arg Val  Lys Pro Arg Leu Leu  Thr Thr Glu Glu Ala  Cys Asp Leu 
    2495                 2500                 2505             


Thr Pro  Pro His Ser Ala Arg  Ser Lys Phe Gly Tyr  Gly Lys Lys 
    2510                 2515                 2520             


Asp Val  Arg Ser His Ser Arg  Lys Ala Ile Asn His  Ile Ser Ser 
    2525                 2530                 2535             


Val Trp  Lys Asp Leu Leu Asp  Asp Asn Asn Thr Pro  Ile Pro Thr 
    2540                 2545                 2550             


Thr Ile  Met Ala Lys Asn Glu  Val Phe Ala Val Asn  Pro Ala Lys 
    2555                 2560                 2565             


Gly Gly  Arg Lys Pro Ala Arg  Leu Ile Val Tyr Pro  Asp Leu Gly 
    2570                 2575                 2580             


Ser Arg  Val Cys Glu Lys Arg  Ala Leu His Asp Val  Ile Lys Lys 
    2585                 2590                 2595             


Thr Ala  Leu Ala Val Met Gly  Ala Ala Tyr Gly Phe  Gln Tyr Ser 
    2600                 2605                 2610             


Pro Ala  Gln Arg Val Glu Phe  Leu Leu Thr Ala Trp  Lys Ser Lys 
    2615                 2620                 2625             


Asn Asp  Pro Met Gly Phe Ser  Tyr Asp Thr Arg Cys  Phe Asp Ser 
    2630                 2635                 2640             


Thr Val  Thr Glu Lys Asp Ile  Arg Val Glu Glu Glu  Val Tyr Gln 
    2645                 2650                 2655             


Cys Cys  Asp Leu Glu Pro Glu  Ala Arg Lys Val Ile  Thr Ala Leu 
    2660                 2665                 2670             


Thr Asp  Arg Leu Tyr Val Gly  Gly Pro Met His Asn  Ser Lys Gly 
    2675                 2680                 2685             


Asp Leu  Cys Gly Tyr Arg Arg  Cys Arg Ala Thr Gly  Val Tyr Thr 
    2690                 2695                 2700             


Thr Ser  Phe Gly Asn Thr Leu  Thr Cys Tyr Leu Lys  Ala Thr Ala 
    2705                 2710                 2715             


Ala Ile  Arg Ala Ala Ala Leu  Arg Asp Cys Thr Met  Leu Val Cys 
    2720                 2725                 2730             


Gly Asp  Asp Leu Val Val Ile  Ala Glu Ser Asp Gly  Val Glu Glu 
    2735                 2740                 2745             


Asp Asn  Arg Ala Leu Arg Ala  Phe Thr Glu Ala Met  Thr Arg Tyr 
    2750                 2755                 2760             


Ser Ala  Pro Pro Gly Asp Ala  Pro Gln Pro Ala Tyr  Asp Leu Glu 
    2765                 2770                 2775             


Leu Ile  Thr Ser Cys Ser Ser  Asn Val Ser Val Ala  His Asp Val 
    2780                 2785                 2790             


Thr Gly  Lys Lys Val Tyr Tyr  Leu Thr Arg Asp Pro  Glu Thr Pro 
    2795                 2800                 2805             


Leu Ala  Arg Ala Val Trp Glu  Thr Val Arg His Thr  Pro Val Asn 
    2810                 2815                 2820             


Ser Trp  Leu Gly Asn Ile Ile  Val Tyr Ala Pro Thr  Ile Trp Val 
    2825                 2830                 2835             


Arg Met  Ile Leu Met Thr His  Phe Phe Ser Ile Leu  Gln Ser Gln 
    2840                 2845                 2850             


Glu Ala  Leu Glu Lys Ala Leu  Asp Phe Asp Met Tyr  Gly Val Thr 
    2855                 2860                 2865             


Tyr Ser  Ile Thr Pro Leu Asp  Leu Pro Ala Ile Ile  Gln Arg Leu 
    2870                 2875                 2880             


His Gly  Leu Ser Ala Phe Thr  Leu His Gly Tyr Ser  Pro His Glu 
    2885                 2890                 2895             


Leu Asn  Arg Val Ala Gly Ala  Leu Arg Lys Leu Gly  Val Pro Pro 
    2900                 2905                 2910             


Leu Arg  Ala Trp Arg His Arg  Ala Arg Ala Val Arg  Ala Lys Leu 
    2915                 2920                 2925             


Ile Ala  Gln Gly Gly Arg Ala  Lys Ile Cys Gly Ile  Tyr Leu Phe 
    2930                 2935                 2940             


Asn Trp  Ala Val Lys Thr Lys  Leu Lys Leu Thr Pro  Leu Pro Ala 
    2945                 2950                 2955             


Ala Ala  Lys Leu Asp Leu Ser  Gly Trp Phe Thr Val  Gly Ala Gly 
    2960                 2965                 2970             


Gly Gly  Asp Ile Tyr His Ser  Met Ser His Ala Arg  Pro Arg Tyr 
    2975                 2980                 2985             


Leu Leu  Leu Cys Leu Leu Ile  Leu Thr Val Gly Val  Gly Ile Phe 
    2990                 2995                 3000             


Leu Leu  Pro Ala Arg 
    3005             


