               SEQUENCE LISTING

<110> SYNHELIX

<120> PEPTIDIC SCAFFOLDS, PROCESSES FOR MANUFACTURING THE SAME, AND USES THEREOF AS SOLUBLE SUPPORTS

<130> IBIO-1333/PCT

<150> EP20305507.4
<151> 2020-05-15

<160> 49

<170> BiSSAP 1.3.6

<210> 1
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X is a reactive amino acid; preferably X is selected from the
      group consisting of K, C, S, T, Y, H and R; preferably X is K or
      C; more preferably X is K

<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 1
Xaa Pro Xaa Xaa Xaa Xaa 
1               5       

<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 2
<223> X is a reactive amino acid; preferably X is selected from the
      group consisting of K, C, S, T, Y, H and R; preferably X is K or
      C; more preferably X is K

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 2
Pro Xaa Xaa Xaa Xaa Xaa 
1               5       

<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 3
Lys Pro Xaa Xaa Xaa Xaa 
1               5       

<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 4
Pro Lys Xaa Xaa Xaa Xaa 
1               5       

<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 5
Lys Pro Xaa Xaa Xaa Xaa 
1               5       

<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 6
Pro Lys Xaa Xaa Xaa Xaa 
1               5       

<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 7
Pro Lys Pro Xaa Xaa Xaa Xaa 
1               5           

<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 8
Lys Pro Lys Xaa Xaa Xaa Xaa 
1               5           

<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 9
Lys Pro Xaa Xaa Xaa Xaa Lys 
1               5           

<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 10
Pro Lys Xaa Xaa Xaa Xaa Pro 
1               5           

<210> 11
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 7
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 11
Lys Pro Xaa Xaa Xaa Xaa Xaa 
1               5           

<210> 12
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 7
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 12
Pro Lys Xaa Xaa Xaa Xaa Xaa 
1               5           

<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 13
Pro Lys Pro Xaa Xaa Xaa Xaa Xaa 
1               5               

<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 14
Lys Pro Lys Xaa Xaa Xaa Xaa Xaa 
1               5               

<210> 15
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 15
Lys Pro Xaa Xaa Xaa Xaa Lys Xaa 
1               5               

<210> 16
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 16
Pro Lys Xaa Xaa Xaa Xaa Pro Xaa 
1               5               

<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 17
Xaa Lys Pro Xaa Xaa Xaa Xaa 
1               5           

<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 18
Xaa Pro Lys Xaa Xaa Xaa Xaa 
1               5           

<210> 19
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 3..8
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 5..8
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 19
Xaa Pro Lys Pro Xaa Xaa Xaa Xaa 
1               5               

<210> 20
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 3..8
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 5..8
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 20
Xaa Lys Pro Lys Xaa Xaa Xaa Xaa 
1               5               

<210> 21
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 21
Xaa Lys Pro Xaa Xaa Xaa Xaa Lys 
1               5               

<210> 22
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 22
Xaa Pro Lys Xaa Xaa Xaa Xaa Pro 
1               5               

<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X, independently from each other, are absent or are a
      non-aromatic amino acid; such as an aliphatic amino acid; such as
      a P

<220> 
<223> Aromatic sequence

<220> 
<221> SITE
<222> 2
<223> X, independently from each other, are absent or are an aromatic
      amino acid; such as W, Y, F, or H; such as W or Y

<220> 
<221> SITE
<222> 3
<223> X, independently from each other, are absent or are a
      non-aromatic amino acid; such as an aliphatic amino acid; such as
      a P

<220> 
<221> SITE
<222> 4
<223> X, independently from each other, are absent or are an aromatic
      amino acid; such as W, Y, F, or H; such as W or Y

<220> 
<221> SITE
<222> 5
<223> X, independently from each other, are absent or are a
      non-aromatic amino acid; such as an aliphatic amino acid; such as
      a P

<220> 
<221> SITE
<222> 6
<223> X, independently from each other, are absent or are an aromatic
      amino acid; such as W, Y, F, or H; such as W or Y

<220> 
<221> SITE
<222> 7
<223> X, independently from each other, are absent or are a
      non-aromatic amino acid; such as an aliphatic amino acid; such as
      a P

<220> 
<221> SITE
<222> 8
<223> X, independently from each other, are absent or are an aromatic
      amino acid; such as W, Y, F, or H; such as W or Y

<220> 
<221> SITE
<222> 9
<223> X, independently from each other, are absent or are a
      non-aromatic amino acid; such as an aliphatic amino acid; such as
      a P

<220> 
<221> SITE
<222> 10
<223> X, independently from each other, are absent or are an aromatic
      amino acid; such as W, Y, F, or H; such as W or Y

<220> 
<221> SITE
<222> 11
<223> X, independently from each other, are absent or are a
      non-aromatic amino acid; such as an aliphatic amino acid; such as
      a P

<400> 23
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10      

<210> 24
<211> 21
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<400> 24
Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys Pro Lys 
1               5                   10                  15      
Pro Tyr Pro Trp Pro 
            20      

<210> 25
<211> 25
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<400> 25
Ala Lys Pro Gly Lys Pro Leu Lys Pro Ala Lys Pro Gly Lys Pro Leu 
1               5                   10                  15      
Lys Pro Gly Lys Pro Tyr Pro Trp Pro 
            20                  25  

<210> 26
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 26
Cys Pro Xaa Xaa Xaa Xaa 
1               5       

<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 27
Pro Cys Xaa Xaa Xaa Xaa 
1               5       

<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 28
Cys Pro Xaa Xaa Xaa Xaa 
1               5       

<210> 29
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 29
Pro Cys Xaa Xaa Xaa Xaa 
1               5       

<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 30
Pro Cys Pro Xaa Xaa Xaa Xaa 
1               5           

<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 31
Cys Pro Cys Xaa Xaa Xaa Xaa 
1               5           

<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 32
Cys Pro Xaa Xaa Xaa Xaa Cys 
1               5           

<210> 33
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 33
Pro Cys Xaa Xaa Xaa Xaa Pro 
1               5           

<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 7
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 34
Cys Pro Xaa Xaa Xaa Xaa Xaa 
1               5           

<210> 35
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 7
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 35
Pro Cys Xaa Xaa Xaa Xaa Xaa 
1               5           

<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 36
Pro Cys Pro Xaa Xaa Xaa Xaa Xaa 
1               5               

<210> 37
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 37
Cys Pro Cys Xaa Xaa Xaa Xaa Xaa 
1               5               

<210> 38
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 38
Cys Pro Xaa Xaa Xaa Xaa Cys Xaa 
1               5               

<210> 39
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> REPEAT
<222> 1..6
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<223> Peptidic scaffold

<220> 
<221> SITE
<222> 3..6
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<220> 
<221> SITE
<222> 8
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<400> 39
Pro Cys Xaa Xaa Xaa Xaa Pro Xaa 
1               5               

<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 40
Xaa Cys Pro Xaa Xaa Xaa Xaa 
1               5           

<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 41
Xaa Pro Cys Xaa Xaa Xaa Xaa 
1               5           

<210> 42
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 3..8
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 5..8
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 42
Xaa Pro Cys Pro Xaa Xaa Xaa Xaa 
1               5               

<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 3..8
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 5..8
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 43
Xaa Cys Pro Cys Xaa Xaa Xaa Xaa 
1               5               

<210> 44
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 44
Xaa Cys Pro Xaa Xaa Xaa Xaa Cys 
1               5               

<210> 45
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<221> SITE
<222> 1
<223> X corresponds to amino acid sequence SEQ ID NO: 23

<220> 
<223> Peptidic scaffold

<220> 
<221> REPEAT
<222> 2..7
<223> Repeated "n" times, “n” being an integral number equal to or
      greater than 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15,
      16, 17, 18, 19, 20

<220> 
<221> SITE
<222> 4..7
<223> X, independently from each other and independently for each “n”
      repeat, are absent or are an aliphatic amino acid, preferably
      selected from the group consisting of A, G, I, L, V and P

<400> 45
Xaa Pro Cys Xaa Xaa Xaa Xaa Pro 
1               5               

<210> 46
<211> 30
<212> DNA
<213> Artificial Sequence


<220> 
<223> Oligo 1

<220> 
<221> misc_feature
<222> 6
<223> /note="Thymidine comprises a 6-FAM label"

<400> 46
gtacctcaat tgataaaaaa ctaagccgga                                     30


<210> 47
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> Oligo 2

<220> 
<221> misc_feature
<222> 6
<223> /note="Thymidine comprises a 6-FAM label"

<400> 47
gtacctagtt attgctcagc gg                                             22


<210> 48
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<400> 48
Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala 
1               5                   10                  15      
Pro Lys Ala Pro Lys Trp Pro Trp 
            20                  

<210> 49
<211> 39
<212> PRT
<213> Artificial Sequence


<220> 
<223> Peptidic scaffold

<400> 49
Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala 
1               5                   10                  15      
Pro Lys Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala Pro Lys Ala Pro 
            20                  25                  30          
Lys Ala Pro Lys Trp Pro Trp 
        35                  

