                         SEQUENCE LISTING

<110>  INSERM
 
<120>  NEW METHOD TO TREAT CUTANEOUS T-CELL LYMPHOMAS AND TFH DERIVED 
       LYMPHOMAS

<130>  BIO19226 OLIVE

<160>  32    

<170>  PatentIn version 3.3

<210>  1
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - H-CDR1 - Amino acids sequence (IMGT)

<400>  1

Gly Tyr Ser Phe Thr Ser Tyr Trp 
1               5               


<210>  2
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - H-CDR2 - Amino acids sequence (IMGT)

<400>  2

Ile Tyr Pro Ser Asp Ser Tyr Thr 
1               5               


<210>  3
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - H-CDR3 - Amino acids sequence (IMGT)

<400>  3

Thr Arg Trp Asn Leu Ser Tyr Tyr Phe Asp Asn Asn Tyr Tyr Leu Asp 
1               5                   10                  15      


Tyr 
    


<210>  4
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - L-CDR1 - Amino acids sequence (IMGT)

<400>  4

Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr 
1               5                   10      


<210>  5
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - L-CDR2 - Amino acids sequence (IMGT)

<400>  5

Arg Met Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - L-CDR3 - Amino acids sequence (IMGT)

<400>  6

Met Gln His Leu Glu Tyr Pro Trp Thr 
1               5                   


<210>  7
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids sequence of the heavy chain (H) of the 88.2 mAb

<400>  7

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Met Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Thr Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp Asn Leu Ser Tyr Tyr Phe Asp Asn Asn Tyr Tyr Leu Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids sequence of the light chain (L) of the 88.2 mAb

<400>  8

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  9
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - H-CDR1 - Amino acids sequence (IMGT)

<400>  9

Gly Tyr Thr Phe Thr Thr Tyr Trp 
1               5               


<210>  10
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - H-CDR2 - Amino acids sequence (IMGT)

<400>  10

Ile Asp Pro Ser Asp Ser Tyr Val 
1               5               


<210>  11
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - H-CDR3 - Amino acids sequence (IMGT)

<400>  11

Ala Arg Ser Pro Asp Tyr Tyr Gly Thr Ser Leu Ala Trp Phe Asp Tyr 
1               5                   10                  15      


<210>  12
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - L-CDR1 - Amino acids sequence (IMGT)

<400>  12

Lys Ser Pro Leu His Ser Asn Gly Asn Ile Tyr 
1               5                   10      


<210>  13
<211>  3
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - L-CDR2 - Amino acids sequence (IMGT)

<400>  13

Arg Met Ser 
1           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - L-CDR3 - Amino acids sequence (IMGT)

<400>  14

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


<210>  15
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids sequence of the heavy chain (H) of the 314.8 mAb

<400>  15

Gln Val Gln Leu Gln Gln Pro Gly Thr Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Val Asn Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Pro Asp Tyr Tyr Gly Thr Ser Leu Ala Trp Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Thr 
        115                 120             


<210>  16
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  Amino acids sequence of the light chain (L) of the 314.8 mAb

<400>  16

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Pro Leu His Ser 
            20                  25                  30          


Asn Gly Asn Ile Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Thr Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  17
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acids sequence of the heavy chain (H) of the 88.2 mAb

<400>  17
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggggcttc agtgaagctg     60

tcctgcaagg cttctggcta cagtttcacc agctactgga taaactgggt gaagcagagg    120

cctggacaag gccttgagtg gatcggaaat atttatcctt ctgatagtta tactaactac    180

aatcaaatgt tcaaggacaa ggccacattg actgtagaca aatcctccaa cacagcctac    240

atgcagctca ccagcccgac atctgaggac tctgcggtct attactgtac aagatggaat    300

ctttcttatt acttcgataa taactactac ttggactact ggggccaagg caccactctc    360

acagtctcct ca                                                        372


<210>  18
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acids sequence of the light chain (L) of the 88.2 mAb

<400>  18
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc     60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg    120

ttcctgcaga ggccaggcca gtctcctcaa ctcctgatat atcggatgtc caaccttgcc    180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc    240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatccg    300

tggacgttcg gtggaggcac caagctggaa atcaaa                              336


<210>  19
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acids sequence of the heavy chain (H) of the 314.8 mAb

<400>  19
caggtccaac tacagcagcc tgggactgaa cttatgaagc ctggggcttc agtgaagctg     60

tcctgcaagg cttctggcta caccttcacc acctactgga tgcactgggt gaagcagagg    120

cctggacaag gccttgagtg gatcggagag attgatcctt ctgatagtta tgttaactac    180

aatcaaaact ttaagggcaa ggccacattg actgtagaca aatcctccag cacagcctac    240

atacagctca gcagcctgac atctgaggac tctgcggtct atttttgtgc gagatcccct    300

gattactacg gtactagtct tgcctggttt gattactggg gccaagggac tctggtcact    360

gtctctaca                                                            369


<210>  20
<211>  336
<212>  DNA
<213>  Artificial

<220>
<223>  Nucleic acids sequence of the light chain (L) of the 314.8 mAb

<400>  20
gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc     60

atctcctgca ggtctagtaa gagtcccctg catagtaacg gcaacattta cttatattgg    120

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc    180

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctactttcac actgaaaatc    240

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatccg    300

tacacgttcg gaggggggac caagctggaa ataaaa                              336


<210>  21
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - H-CDR1 - Amino acids sequence (KABAT)

<400>  21

Ser Tyr Trp Ile Asn 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - H-CDR2 - Amino acids sequence (KABAT)

<400>  22

Asn Ile Tyr Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Met Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  23
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - H-CDR3 - Amino acids sequence (KABAT)

<400>  23

Trp Asn Leu Ser Tyr Tyr Phe Asp Asn Asn Tyr Tyr Leu Asp Tyr 
1               5                   10                  15  


<210>  24
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - L-CDR1 - Amino acids sequence (KABAT)

<400>  24

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  25
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - L-CDR2 - Amino acids sequence (KABAT)

<400>  25

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  88.2 antibody - L-CDR3 - Amino acids sequence (KABAT)

<400>  26

Met Gln His Leu Glu Tyr Pro Trp Thr 
1               5                   


<210>  27
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - H-CDR1 - Amino acids sequence (KABAT)

<400>  27

Thr Tyr Trp Met His 
1               5   


<210>  28
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - H-CDR2 - Amino acids sequence (KABAT)

<400>  28

Glu Ile Asp Pro Ser Asp Ser Tyr Val Asn Tyr Asn Gln Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  29
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - H-CDR3 - Amino acids sequence (KABAT)

<400>  29

Ser Pro Asp Tyr Tyr Gly Thr Ser Leu Ala Trp Phe Asp Tyr 
1               5                   10                  


<210>  30
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - L-CDR1 - Amino acids sequence (KABAT)

<400>  30

Arg Ser Ser Lys Ser Pro Leu His Ser Asn Gly Asn Ile Tyr Leu Tyr 
1               5                   10                  15      


<210>  31
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - L-CDR2 - Amino acids sequence (KABAT)

<400>  31

Arg Met Ser Asn Leu Ala Ser 
1               5           


<210>  32
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  314.8 antibody - L-CDR3 - Amino acids sequence (KABAT)

<400>  32

Met Gln His Leu Glu Tyr Pro Tyr Thr 
1               5                   


