                         SEQUENCE LISTING

<110>  INSERM
 
<120>  Recombinant proteins with OX40 activating proteins

<130>  BIO20071

<150>  EP20305487.9
<151>  2020-05-13

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Cys Val Gly Ala Arg Arg Leu Gly Arg Gly Pro Cys Ala Ala Leu 
1               5                   10                  15      


Leu Leu Leu Gly Leu Gly Leu Ser Thr Val Thr Gly Leu His Cys Val 
            20                  25                  30          


Gly Asp Thr Tyr Pro Ser Asn Asp Arg Cys Cys His Glu Cys Arg Pro 
        35                  40                  45              


Gly Asn Gly Met Val Ser Arg Cys Ser Arg Ser Gln Asn Thr Val Cys 
    50                  55                  60                  


Arg Pro Cys Gly Pro Gly Phe Tyr Asn Asp Val Val Ser Ser Lys Pro 
65                  70                  75                  80  


Cys Lys Pro Cys Thr Trp Cys Asn Leu Arg Ser Gly Ser Glu Arg Lys 
                85                  90                  95      


Gln Leu Cys Thr Ala Thr Gln Asp Thr Val Cys Arg Cys Arg Ala Gly 
            100                 105                 110         


Thr Gln Pro Leu Asp Ser Tyr Lys Pro Gly Val Asp Cys Ala Pro Cys 
        115                 120                 125             


Pro Pro Gly His Phe Ser Pro Gly Asp Asn Gln Ala Cys Lys Pro Trp 
    130                 135                 140                 


Thr Asn Cys Thr Leu Ala Gly Lys His Thr Leu Gln Pro Ala Ser Asn 
145                 150                 155                 160 


Ser Ser Asp Ala Ile Cys Glu Asp Arg Asp Pro Pro Ala Thr Gln Pro 
                165                 170                 175     


Gln Glu Thr Gln Gly Pro Pro Ala Arg Pro Ile Thr Val Gln Pro Thr 
            180                 185                 190         


Glu Ala Trp Pro Arg Thr Ser Gln Gly Pro Ser Thr Arg Pro Val Glu 
        195                 200                 205             


Val Pro Gly Gly Arg Ala Val Ala Ala Ile Leu Gly Leu Gly Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Gly Pro Leu Ala Ile Leu Leu Ala Leu Tyr Leu Leu 
225                 230                 235                 240 


Arg Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly 
                245                 250                 255     


Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser 
            260                 265                 270         


Thr Leu Ala Lys Ile 
        275         


<210>  2
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Ser His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile 
1               5                   10                  15      


Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe 
            20                  25                  30          


Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn 
        35                  40                  45              


Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly 
    50                  55                  60                  


Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu 
65                  70                  75                  80  


Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met 
                85                  90                  95      


Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr 
            100                 105                 110         


Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile 
        115                 120                 125             


Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu Ala Ser 
    130                 135                 140         


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  3

Gly Gly Ser Phe Ser Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  4
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  4

Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  5
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  5

Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr 
1               5                   10              


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  6

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  7

Tyr Thr Ser Lys Leu His Ser 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  8

Gln Gln Gly Ser Ala Leu Pro Trp Thr 
1               5                   


<210>  9
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Ala Ser 
    450             


<210>  10
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser 
    210                 215     


<210>  11
<211>  453
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  11

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asn Gly Ile Thr Tyr His Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Ile Thr Ile Asn Arg Asp Thr Ser Lys Asn Gln Tyr Ser Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Lys Tyr Asp Tyr Asp Gly Gly His Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys Ala Ser 
    450             


<210>  12
<211>  385
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ala Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Ala Ser Gln Thr Pro Thr Asn Thr Ile Ser 
    210                 215                 220                 


Val Thr Pro Thr Asn Asn Ser Thr Pro Thr Asn Asn Ser Asn Pro Lys 
225                 230                 235                 240 


Pro Asn Pro Ala Ser His Phe Ser Ala Leu Gln Val Ser His Arg Tyr 
                245                 250                 255     


Pro Arg Ile Gln Ser Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu 
            260                 265                 270         


Lys Gly Phe Ile Leu Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val 
        275                 280                 285             


Gln Asn Asn Ser Val Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser 
    290                 295                 300                 


Leu Lys Gly Tyr Phe Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln 
305                 310                 315                 320 


Lys Asp Glu Glu Pro Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn 
                325                 330                 335     


Ser Leu Met Val Ala Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn 
            340                 345                 350         


Val Thr Thr Asp Asn Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly 
        355                 360                 365             


Glu Leu Ile Leu Ile His Gln Asn Pro Gly Glu Phe Cys Val Leu Ala 
    370                 375                 380                 


Ser 
385 


<210>  13
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  linker

<400>  13

Ala Ser Gln Thr Pro Thr Asn Thr Ile Ser Val Thr Pro Thr Asn Asn 
1               5                   10                  15      


Ser Thr Pro Thr Asn Asn Ser Asn Pro Lys Pro Asn Pro Ala Ser 
            20                  25                  30      


<210>  14
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  14
atggatccta agggctctct gtcttggaga atcctgctgt ttctgtctct ggcctttgag       60

ctgtcttacg gccaggtgca gctgcaggag tctggacctg gcctggtgaa gccttctcag      120

accctgtctc tgacatgtgc cgtgtacgga ggctcttttt cttctggcta ctggaactgg      180

attagaaagc accctggaaa gggcctggag tacattggct acatctctta caacggcatc      240

acatatcata acccttctct gaagtctaga atcacaatta acagagatac atctaagaac      300

cagtactctc tgcagctgaa ctctgtgaca cctgaggata cagccgtgta ctactgtgcc      360

agatacaagt acgattatga tggcggccac gctatggatt actggggaca gggaacactg      420

gtgaccgtgt cttctgcttc tacaaagggc ccatcggtct tccccctggc gccctgctcc      480

aggagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      780

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaagctag ctga           1434


<210>  15
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  15
atggatccta agggctctct gtcttggaga atcctgctgt tcctgtctct ggcttttgag       60

ctgtcttacg gcgatatcca gatgacacag tctccttctt ctctgtctgc ctctgtgggc      120

gatagagtga ccatcacatg tagagcctct caggatatct ctaactacct gaactggtac      180

cagcagaagc ctggcaaggc cccaaagctg ctgatctatt acacatctaa gctgcactct      240

ggcgtgcctt ctagattttc tggctctgga tctggcacag attatacact gaccatctct      300

tctctgcagc ctgaagattt tgctacatac tactgtcagc agggctctgc tctgccttgg      360

acctttggac agggcacaaa ggtggagatc aagcgaactg tggctgcacc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctatgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtgctagc      720

tga                                                                    723


<210>  16
<211>  1434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  16
atggatccta agggctctct gtcttggaga atcctgctgt ttctgtctct ggcctttgag       60

ctgtcttacg gccaggtgca gctgcaggag tctggacctg gcctggtgaa gccttctcag      120

accctgtctc tgacatgtgc cgtgtacgga ggctcttttt cttctggcta ctggaactgg      180

attagaaagc accctggaaa gggcctggag tacattggct acatctctta caacggcatc      240

acatatcata acccttctct gaagtctaga atcacaatta acagagatac atctaagaac      300

cagtactctc tgcagctgaa ctctgtgaca cctgaggata cagccgtgta ctactgtgcc      360

agatacaagt acgattatga tggcggccac gctatggatt actggggaca gggaacactg      420

gtgaccgtgt cttctgcttc tacaaagggc ccatcggtct tccccctggc gccctgctcc      480

aggagcacct ctgggggcac agcggccctg ggctgcctgg tcaaggacta cttccccgaa      540

ccggtgacgg tgtcgtggaa ctcaggcgcc ctgaccagcg gcgtgcacac cttcccggct      600

gtcctacagt cctcaggact ctactccctc agcagcgtgg tgaccgtgcc ctccagcagc      660

ttgggcaccc agacctacat ctgcaacgtg aatcacaagc ccagcaacac caaggtggac      720

aagagagttg agcccaaatc ttgtgacaaa actcacacat gcccaccgtg cccagcacct      780

gaactcctgg ggggaccgtc agtcttcctc ttccccccaa aacccaagga caccctcatg      840

atctcccgga cccctgaggt cacatgcgtg gtggtggacg tgagccacga agaccctgag      900

gtcaagttca actggtacgt ggacggcgtg gaggtgcata atgccaagac aaagccgcgg      960

gaggagcagt acaacagcac gtaccgtgtg gtcagcgtcc tcaccgtcct gcaccaggac     1020

tggctgaatg gcaaggagta caagtgcaag gtctccaaca aagccctccc agcccccatc     1080

gagaaaacca tctccaaagc caaagggcag ccccgagaac cacaggtgta caccctgccc     1140

ccatcccggg atgagctgac caagaaccag gtcagcctga cctgcctggt caaaggcttc     1200

tatcccagcg acatcgccgt ggagtgggag agcaatgggc agccggagaa caactacaag     1260

accacgcctc ccgtgctgga ctccgacggc tccttcttcc tctacagcaa gctcaccgtg     1320

gacaagagca ggtggcagca ggggaacgtc ttctcatgct ccgtgatgca tgaggctctg     1380

cacaaccact acacgcagaa gagcctctcc ctgtctccgg gtaaagctag ctga           1434


<210>  17
<211>  1227
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody

<400>  17
atggatccta agggctctct gtcttggaga atcctgctgt tcctgtctct ggcttttgag       60

ctgtcttacg gcgatatcca gatgacacag tctccttctt ctctgtctgc ctctgtgggc      120

gatagagtga ccatcacatg tagagcctct caggatatct ctaactacct gaactggtac      180

cagcagaagc ctggcaaggc cccaaagctg ctgatctatt acacatctaa gctgcactct      240

ggcgtgcctt ctagattttc tggctctgga tctggcacag attatacact gaccatctct      300

tctctgcagc ctgaagattt tgctacatac tactgtcagc agggctctgc tctgccttgg      360

acctttggac agggcacaaa ggtggagatc aagcgaactg tggctgcacc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctatgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgtgctagt      720

cagaccccca ccaacaccat cagcgtgacc cccaccaaca acagcacccc caccaacaac      780

agcaacccca agcccaaccc cgctagtcat ttctcagctt tgcaagtgtc ccacagatac      840

ccaaggatcc agtccatcaa ggtgcagttc acagagtaca agaaggagaa agggttcatc      900

ctgacatccc agaaagagga cgagatcatg aaggtccaga acaacagtgt gattatcaac      960

tgcgacggct tctacctcat tagcctgaag gggtactttt ctcaggaggt gaatatttcc     1020

ctgcactacc agaaggatga ggagcctctc tttcagttga agaaggtgcg gagcgtgaac     1080

agccttatgg tcgccagcct gacatataag gacaaggtgt acctgaacgt gaccactgat     1140

aacaccagcc tcgatgattt tcacgtcaac gggggagaac tcattctgat ccaccagaac     1200

cccggcgaat tttgtgtcct ggctagc                                         1227


<210>  18
<211>  138
<212>  PRT
<213>  Homo sapiens

<400>  18

His Phe Ser Ala Leu Gln Val Ser His Arg Tyr Pro Arg Ile Gln Ser 
1               5                   10                  15      


Ile Lys Val Gln Phe Thr Glu Tyr Lys Lys Glu Lys Gly Phe Ile Leu 
            20                  25                  30          


Thr Ser Gln Lys Glu Asp Glu Ile Met Lys Val Gln Asn Asn Ser Val 
        35                  40                  45              


Ile Ile Asn Cys Asp Gly Phe Tyr Leu Ile Ser Leu Lys Gly Tyr Phe 
    50                  55                  60                  


Ser Gln Glu Val Asn Ile Ser Leu His Tyr Gln Lys Asp Glu Glu Pro 
65                  70                  75                  80  


Leu Phe Gln Leu Lys Lys Val Arg Ser Val Asn Ser Leu Met Val Ala 
                85                  90                  95      


Ser Leu Thr Tyr Lys Asp Lys Val Tyr Leu Asn Val Thr Thr Asp Asn 
            100                 105                 110         


Thr Ser Leu Asp Asp Phe His Val Asn Gly Gly Glu Leu Ile Leu Ile 
        115                 120                 125             


His Gln Asn Pro Gly Glu Phe Cys Val Leu 
    130                 135             


