                         SEQUENCE LISTING

<110>  Janssen Vaccines & Prevention B.V
 
<120>  Administration of homologous adenoviral vectors

<130>  CRU6035WOPCT

<150>  EP20174221.0
<151>  2020-05-12

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  774
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HPV16.E6E7

<400>  1
atgcaccaga aacggaccgc catgttccag gacccccagg aacggcccag aaagctgccc       60

cagctgtgca ccgagctgca gaccaccatc cacgacatca tcctggaatg cgtgtactgc      120

aagcagcagc tcctgcggag agaggtgtac gacttcgcct tccgggacct gtgtatcgtg      180

taccgggacg gcaaccccta cgccgtgtgc gacaagtgcc tgaagttcta cagcaagatc      240

agcgagtacc ggcactactg ctacagcctg tacggcacca ccctggaaca gcagtacaac      300

aagcccctgt gcgacctgct gatccggtgc atcaactgcc agaaacccct gtgccccgag      360

gaaaagcagc ggcacctgga caagaagcag cggttccaca acatccgggg cagatggaca      420

ggccggtgca tgagctgctg cagaagcagc cggaccagac gggaaaccca gctgatgcac      480

ggcgacaccc ccaccctgca cgagtacatg ctggacctgc agcccgagac aaccgacctg      540

tactgctacg agcagctgaa cgacagcagc gaggaagagg acgagatcga cggccctgct      600

ggacaggccg agcctgatag agcccactac aatatcgtga ccttctgctg caagtgcgac      660

agcaccctgc ggctgtgcgt gcagagcacc cacgtggaca tccggaccct ggaagatctg      720

ctgatgggca ccctgggcat cgtgtgcccc atctgctccc agaaaccctg ataa            774


<210>  2
<211>  256
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  .HPV16.E6E7

<400>  2

Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Asn Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Gly Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu Met His 
145                 150                 155                 160 


Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln Pro Glu 
                165                 170                 175     


Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu 
            180                 185                 190         


Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala 
        195                 200                 205             


His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg 
    210                 215                 220                 


Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu Asp Leu 
225                 230                 235                 240 


Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln Lys Pro 
                245                 250                 255     


<210>  3
<211>  4056
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Mos1.gag-pol

<400>  3
atgggagcca gagccagcgt gctgtccgga ggggagctgg accgctggga gaagatcagg       60

ctgaggcctg gagggaagaa gaagtacagg ctgaagcaca tcgtgtgggc cagcagagag      120

ctggaacggt ttgccgtgaa ccctggcctg ctggaaacca gcgagggctg taggcagatt      180

ctgggacagc tgcagcccag cctgcagaca ggcagcgagg aactgcggag cctgtacaac      240

accgtggcca ccctgtactg cgtgcaccag cggatcgaga tcaaggacac caaagaagcc      300

ctggaaaaga tcgaggaaga gcagaacaag agcaagaaga aagcccagca ggctgccgct      360

gacacaggca acagcagcca ggtgtcccag aactacccca tcgtgcagaa catccaggga      420

cagatggtgc accaggccat cagccctcgg accctgaacg cctgggtgaa ggtggtggag      480

gaaaaggcct tcagccctga ggtgatcccc atgttctctg ccctgagcga gggagccaca      540

ccccaggacc tgaacaccat gctgaacacc gtgggagggc accaggctgc catgcagatg      600

ctgaaagaga caatcaacga ggaagctgcc gagtgggaca gggtccaccc agtgcacgct      660

ggacctatcg ctcctggcca gatgagagag cccagaggca gcgatattgc tggcaccacc      720

tccacactgc aggaacagat cggctggatg accaacaacc ctcccatccc tgtgggagag      780

atctacaagc ggtggatcat tctgggactg aacaagatcg tgcggatgta cagccctgtg      840

agcatcctgg acatcaggca gggacccaaa gagcccttca gggactacgt ggaccggttc      900

tacaagaccc tgagagccga gcaggccagc caggacgtga agaactggat gaccgagaca      960

ctgctggtgc agaacgccaa ccctgactgc aagaccatcc tgaaagccct gggacctgct     1020

gccaccctgg aagagatgat gacagcctgc cagggagtgg gaggacctgg ccacaaggcc     1080

agggtgctgg ccgaggccat gagccaggtg accaactctg ccaccatcat gatgcagaga     1140

ggcaacttcc ggaaccagag aaagaccgtg aagtgcttca actgtggcaa agagggacac     1200

attgccaaga actgcagggc tcccaggaag aaaggctgct ggaagtgcgg aaaagaaggc     1260

caccagatga aggactgcac cgagaggcag gccaacttcc tgggcaagat ctggcctagc     1320

aacaagggca ggcctggcaa cttcctgcag aacagacccg agcccaccgc tcctcccgag     1380

gaaagcttcc ggtttggcga ggaaaccacc acccctagcc agaagcagga acccatcgac     1440

aaagagatgt accctctggc cagcctgaag agcctgttcg gcaacgaccc cagcagccag     1500

atggctccca tcagcccaat cgagacagtg cctgtgaagc tgaagcctgg catggacgga     1560

cccagggtga agcagtggcc tctgaccgag gaaaagatca aagccctgac agccatctgc     1620

gaggaaatgg aaaaagaggg caagatcacc aagatcggac ccgagaaccc ctacaacacc     1680

cctgtgttcg ccatcaagaa gaaagacagc accaagtgga ggaaactggt ggacttcaga     1740

gagctgaaca agcggaccca ggacttctgg gaggtgcagc tgggcatccc tcaccctgct     1800

ggcctgaaga aaaagaaaag cgtgaccgtg ctggctgtgg gagatgccta cttcagcgtg     1860

cctctggacg agggcttccg gaagtacaca gccttcacca tccccagcac caacaacgag     1920

acacctggca tcagatacca gtacaacgtg ctgcctcagg gctggaaagg cagccctgcc     1980

atcttccagt gcagcatgac cagaatcctg gaacccttca gagccaagaa ccctgagatc     2040

gtgatctacc agtatatggc tgccctctac gtgggcagcg acctggaaat cggacagcac     2100

agagccaaaa tcgaagaact ccgcgagcac ctgctgaagt ggggattcac cacccctgac     2160

aagaagcacc agaaagagcc tcccttcctg tggatgggct acgagctgca ccctgacaag     2220

tggaccgtgc agcccatcca gctgccagag aaggactcct ggaccgtgaa cgacatccag     2280

aaactggtcg gcaagctgaa ctgggccagc cagatctacc ctggcatcaa agtcagacag     2340

ctgtgtaagc tgctgagggg agccaaagca ctgaccgaca tcgtgcctct gacagaagaa     2400

gccgagctgg aactggccga gaacagagag atcctgaaag aacccgtgca cggagtgtac     2460

tacgacccct ccaaggacct gattgccgag atccagaaac agggacacga ccagtggacc     2520

taccagatct atcaggaacc tttcaagaac ctgaaaacag gcaagtacgc caagatgcgg     2580

acagcccaca ccaacgacgt gaagcagctg accgaagccg tgcagaaaat cgccatggaa     2640

agcatcgtga tctggggaaa gacacccaag ttcaggctgc ccatccagaa agagacatgg     2700

gaaacctggt ggaccgacta ctggcaggcc acctggattc ccgagtggga gttcgtgaac     2760

accccacccc tggtgaagct gtggtatcag ctggaaaagg accctatcgc tggcgtggag     2820

acattctacg tggctggagc tgccaacaga gagacaaagc tgggcaaggc tggctacgtg     2880

accgacagag gcagacagaa aatcgtgagc ctgaccgaaa ccaccaacca gaaaacagcc     2940

ctgcaggcca tctatctggc actgcaggac agcggaagcg aggtgaacat cgtgacagcc     3000

agccagtatg ccctgggcat catccaggcc cagcctgaca agagcgagag cgagctggtg     3060

aaccagatca tcgagcagct gatcaagaaa gaacgggtgt acctgagctg ggtgccagcc     3120

cacaagggca tcggagggaa cgagcaggtg gacaagctgg tgtccagcgg aatccggaag     3180

gtgctgttcc tggacggcat cgataaagcc caggaagagc acgagaagta ccacagcaat     3240

tggagagcca tggccagcga cttcaacctg cctcccgtgg tggccaaaga aatcgtggcc     3300

agctgcgacc agtgccagct gaaaggcgag gccatgcacg gacaggtgga ctgctcccct     3360

ggcatctggc agctggcatg cacccacctg gaaggcaaga tcattctggt ggccgtgcac     3420

gtggccagcg gatacatcga agccgaagtg atccctgccg agacagggca ggaaacagcc     3480

tacttcatcc tgaagctggc tggcagatgg cctgtgaagg tgatccacac agccaacggc     3540

agcaacttca cctctgctgc cgtgaaggct gcctgttggt gggctggcat tcagcaggaa     3600

tttggcatcc cctacaatcc ccagtctcag ggagtggtgg ccagcatgaa caaagagctg     3660

aagaagatca tcggacaggt cagggatcag gccgagcacc tgaaaactgc cgtccagatg     3720

gccgtgttca tccacaactt caagcggaag ggagggatcg gagggtactc tgctggcgag     3780

cggatcatcg acatcattgc caccgatatc cagaccaaag agctgcagaa acagatcatc     3840

aagatccaga acttcagggt gtactacagg gacagcaggg accccatctg gaagggacct     3900

gccaagctgc tgtggaaagg cgaaggagcc gtcgtcatcc aggacaacag cgacatcaag     3960

gtggtgccca gacggaaggt gaaaatcatc aaggactacg gcaaacagat ggctggagcc     4020

gactgtgtcg ctggcaggca ggacgaggac taatga                               4056


<210>  4
<211>  1350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mos1.Gag-Pol.v3

<400>  4

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Arg Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Glu Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Val Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Asp Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Ser Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Asn Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Asn Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 
    450                 455                 460                 


Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 
465                 470                 475                 480 


Lys Glu Met Tyr Pro Leu Ala Ser Leu Lys Ser Leu Phe Gly Asn Asp 
                485                 490                 495     


Pro Ser Ser Gln Met Ala Pro Ile Ser Pro Ile Glu Thr Val Pro Val 
            500                 505                 510         


Lys Leu Lys Pro Gly Met Asp Gly Pro Arg Val Lys Gln Trp Pro Leu 
        515                 520                 525             


Thr Glu Glu Lys Ile Lys Ala Leu Thr Ala Ile Cys Glu Glu Met Glu 
    530                 535                 540                 


Lys Glu Gly Lys Ile Thr Lys Ile Gly Pro Glu Asn Pro Tyr Asn Thr 
545                 550                 555                 560 


Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr Lys Trp Arg Lys Leu 
                565                 570                 575     


Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln Asp Phe Trp Glu Val 
            580                 585                 590         


Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys Lys Lys Lys Ser Val 
        595                 600                 605             


Thr Val Leu Ala Val Gly Asp Ala Tyr Phe Ser Val Pro Leu Asp Glu 
    610                 615                 620                 


Gly Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro Ser Thr Asn Asn Glu 
625                 630                 635                 640 


Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu Pro Gln Gly Trp Lys 
                645                 650                 655     


Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr Arg Ile Leu Glu Pro 
            660                 665                 670         


Phe Arg Ala Lys Asn Pro Glu Ile Val Ile Tyr Gln Tyr Met Ala Ala 
        675                 680                 685             


Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln His Arg Ala Lys Ile 
    690                 695                 700                 


Glu Glu Leu Arg Glu His Leu Leu Lys Trp Gly Phe Thr Thr Pro Asp 
705                 710                 715                 720 


Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp Met Gly Tyr Glu Leu 
                725                 730                 735     


His Pro Asp Lys Trp Thr Val Gln Pro Ile Gln Leu Pro Glu Lys Asp 
            740                 745                 750         


Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val Gly Lys Leu Asn Trp 
        755                 760                 765             


Ala Ser Gln Ile Tyr Pro Gly Ile Lys Val Arg Gln Leu Cys Lys Leu 
    770                 775                 780                 


Leu Arg Gly Ala Lys Ala Leu Thr Asp Ile Val Pro Leu Thr Glu Glu 
785                 790                 795                 800 


Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile Leu Lys Glu Pro Val 
                805                 810                 815     


His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu Ile Ala Glu Ile Gln 
            820                 825                 830         


Lys Gln Gly His Asp Gln Trp Thr Tyr Gln Ile Tyr Gln Glu Pro Phe 
        835                 840                 845             


Lys Asn Leu Lys Thr Gly Lys Tyr Ala Lys Met Arg Thr Ala His Thr 
    850                 855                 860                 


Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln Lys Ile Ala Met Glu 
865                 870                 875                 880 


Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe Arg Leu Pro Ile Gln 
                885                 890                 895     


Lys Glu Thr Trp Glu Thr Trp Trp Thr Asp Tyr Trp Gln Ala Thr Trp 
            900                 905                 910         


Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro Leu Val Lys Leu Trp 
        915                 920                 925             


Tyr Gln Leu Glu Lys Asp Pro Ile Ala Gly Val Glu Thr Phe Tyr Val 
    930                 935                 940                 


Ala Gly Ala Ala Asn Arg Glu Thr Lys Leu Gly Lys Ala Gly Tyr Val 
945                 950                 955                 960 


Thr Asp Arg Gly Arg Gln Lys Ile Val Ser Leu Thr Glu Thr Thr Asn 
                965                 970                 975     


Gln Lys Thr Ala Leu Gln Ala Ile Tyr Leu Ala Leu Gln Asp Ser Gly 
            980                 985                 990         


Ser Glu Val Asn Ile Val Thr Ala  Ser Gln Tyr Ala Leu  Gly Ile Ile 
        995                 1000                 1005             


Gln Ala  Gln Pro Asp Lys Ser  Glu Ser Glu Leu Val  Asn Gln Ile 
    1010                 1015                 1020             


Ile Glu  Gln Leu Ile Lys Lys  Glu Arg Val Tyr Leu  Ser Trp Val 
    1025                 1030                 1035             


Pro Ala  His Lys Gly Ile Gly  Gly Asn Glu Gln Val  Asp Lys Leu 
    1040                 1045                 1050             


Val Ser  Ser Gly Ile Arg Lys  Val Leu Phe Leu Asp  Gly Ile Asp 
    1055                 1060                 1065             


Lys Ala  Gln Glu Glu His Glu  Lys Tyr His Ser Asn  Trp Arg Ala 
    1070                 1075                 1080             


Met Ala  Ser Asp Phe Asn Leu  Pro Pro Val Val Ala  Lys Glu Ile 
    1085                 1090                 1095             


Val Ala  Ser Cys Asp Gln Cys  Gln Leu Lys Gly Glu  Ala Met His 
    1100                 1105                 1110             


Gly Gln  Val Asp Cys Ser Pro  Gly Ile Trp Gln Leu  Ala Cys Thr 
    1115                 1120                 1125             


His Leu  Glu Gly Lys Ile Ile  Leu Val Ala Val His  Val Ala Ser 
    1130                 1135                 1140             


Gly Tyr  Ile Glu Ala Glu Val  Ile Pro Ala Glu Thr  Gly Gln Glu 
    1145                 1150                 1155             


Thr Ala  Tyr Phe Ile Leu Lys  Leu Ala Gly Arg Trp  Pro Val Lys 
    1160                 1165                 1170             


Val Ile  His Thr Ala Asn Gly  Ser Asn Phe Thr Ser  Ala Ala Val 
    1175                 1180                 1185             


Lys Ala  Ala Cys Trp Trp Ala  Gly Ile Gln Gln Glu  Phe Gly Ile 
    1190                 1195                 1200             


Pro Tyr  Asn Pro Gln Ser Gln  Gly Val Val Ala Ser  Met Asn Lys 
    1205                 1210                 1215             


Glu Leu  Lys Lys Ile Ile Gly  Gln Val Arg Asp Gln  Ala Glu His 
    1220                 1225                 1230             


Leu Lys  Thr Ala Val Gln Met  Ala Val Phe Ile His  Asn Phe Lys 
    1235                 1240                 1245             


Arg Lys  Gly Gly Ile Gly Gly  Tyr Ser Ala Gly Glu  Arg Ile Ile 
    1250                 1255                 1260             


Asp Ile  Ile Ala Thr Asp Ile  Gln Thr Lys Glu Leu  Gln Lys Gln 
    1265                 1270                 1275             


Ile Ile  Lys Ile Gln Asn Phe  Arg Val Tyr Tyr Arg  Asp Ser Arg 
    1280                 1285                 1290             


Asp Pro  Ile Trp Lys Gly Pro  Ala Lys Leu Leu Trp  Lys Gly Glu 
    1295                 1300                 1305             


Gly Ala  Val Val Ile Gln Asp  Asn Ser Asp Ile Lys  Val Val Pro 
    1310                 1315                 1320             


Arg Arg  Lys Val Lys Ile Ile  Lys Asp Tyr Gly Lys  Gln Met Ala 
    1325                 1330                 1335             


Gly Ala  Asp Cys Val Ala Gly  Arg Gln Asp Glu Asp  
    1340                 1345                 1350 


