
                                SEQUENCE LISTING

<110> Adagene AG

<120> COMPOSITIONS AND METHODS FOR TREATING CANCER

<130> 69540-20012.45

<140> Not Yet Assigned
<141> Concurrently Herewith

<150> PCT/CN2020/115795 
<151> 2020-09-17

<150> PCT/CN2020/094278
<151> 2020-06-04

<150> PCT/CN2019/090073
<151> 2020-05-13

<160> 89

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 255
<212> PRT
<213> Homo sapiens

<400> 1
Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu
 1               5                  10                  15      
Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro
            20                  25                  30          
Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys
        35                  40                  45              
Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile
    50                  55                  60                  
Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser
65                  70                  75                  80  
Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly
                85                  90                  95      
Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu
            100                 105                 110         
Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln
        115                 120                 125             
Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys
    130                 135                 140                 
Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro
145                 150                 155                 160 
Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala
                165                 170                 175     
Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu
            180                 185                 190         
Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu
        195                 200                 205             
Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe
    210                 215                 220                 
Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly
225                 230                 235                 240 
Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu
                245                 250                 255 


<210> 2
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 2
Phe Ser Leu Ser Thr Gly Gly Val Gly Val Gly Trp Ile
 1               5                  10              


<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 3
Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 4
Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
 1               5                  10                  15  


<210> 5
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 5
Arg Ala Ser Gln Ser Ile Gly Ser Tyr Leu Ala
 1               5                  10      


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 6
Asp Ala Ser Asn Leu Glu Thr Gly Val
 1               5                  


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 7
Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
 1               5                  10  


<210> 8
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 8
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Gly
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 9
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 9
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 10
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 10
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Gly
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Ala Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Ile Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
        435                 440                 445             
Gly Lys
    450 


<210> 11
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 11
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 12
Tyr Ser Ile Thr Ser Gly His Tyr Trp Ala Trp Ile
 1               5                  10          


<210> 13
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 13
Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser
 1               5                  10                  15      
Val Lys Gly Arg Phe
            20      


<210> 14
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 14
Ala Arg Gly Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr
 1               5                  10                  15  


<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 15
Arg Ala Ser Gln Gly Ile Gly Ser Phe Leu Ala
 1               5                  10      


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 16
Asp Ala Ser Asn Leu Glu Thr Gly Val
 1               5                  


<210> 17
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 17
Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
 1               5                  10  


<210> 18
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          
His Tyr Trp Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 19
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 19
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Phe
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 20
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 20
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Thr Ser Gly
            20                  25                  30          
His Tyr Trp Ala Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Val Ser Ser Ile Ser Gly Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Ala Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
        435                 440                 445             
Gly Lys
    450 


<210> 21
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 21
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Ser Phe
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Tyr Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 22
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 22
Phe Ser Leu Ser Thr Ser Gly Val Gly Val Gly Trp Ile
 1               5                  10              


<210> 23
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 23
Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 24
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 24
Ala Arg Gly Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr
 1               5                  10                  15  


<210> 25
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 25
Arg Ala Ser Gln Ser Val Ser Pro Tyr Leu Ala
 1               5                  10      


<210> 26
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 26
Asp Ala Ser Ser Leu Glu Ser Gly Val
 1               5                  


<210> 27
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 27
Tyr Cys Gln Gln Gly Tyr Ser Leu Trp Thr
 1               5                  10  


<210> 28
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 28
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 29
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 29
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Pro Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105         


<210> 30
<211> 450
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 30
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Val Gly Val Gly Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Gly Ser Asp Thr Val Leu Gly Asp Trp Phe Ala Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys
    210                 215                 220                 
Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly
225                 230                 235                 240 
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255     
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu
            260                 265                 270         
Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285             
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg
    290                 295                 300                 
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 
Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu
                325                 330                 335     
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350         
Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365             
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380                 
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp
                405                 410                 415     
Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430         
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu
        435                 440                 445             
Gly Lys
    450 


<210> 31
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 31
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Pro Tyr
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Tyr Ser Leu Trp Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn Arg Gly Glu Cys
    210             


<210> 32
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Phe or Tyr

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Gly, Asn, or Ser

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Ala, Gly, or Trp

<400> 32
Xaa Thr Phe Xaa Xaa Tyr Xaa Ile His Trp Val
 1               5                  10      


<210> 33
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = His or Tyr

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = His or Tyr

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Ala, Asp, Gly, Asn, Ser, or Thr

<400> 33
Tyr Ser Ile Xaa Ser Gly Xaa Xaa Trp Xaa Trp Ile
 1               5                  10          


<210> 34
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Gly or Ser

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ala or Gly

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Ala, Gly, Ser, or Thr

<400> 34
Phe Ser Leu Ser Thr Xaa Gly Val Xaa Val Xaa Trp Ile
 1               5                  10              


<210> 35
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Ala, Asp, or Tyr

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Asp or Gly

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Arg, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = Pro or Thr

<400> 35
Leu Ala Leu Ile Asp Trp Xaa Xaa Asp Lys Xaa Tyr Ser Xaa Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 36
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Asp or Glu

<220> 
<221> VARIANT        
<222> 9, 13
<223> Xaa = Asn or Ser

<400> 36
Ile Gly Xaa Ile Tyr His Ser Gly Xaa Thr Tyr Tyr Xaa Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Val
            20  


<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Ala, Gly, Ser, Val, or Tyr

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Ala, Asp, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Asp, Gly, or Ser

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Ser or Thr

<400> 37
Val Ser Xaa Ile Ser Gly Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser
 1               5                  10                  15      
Val Lys Gly Arg Phe
            20      


<210> 38
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Glu or Gly

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Glu or Ser

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Asp or Thr

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Ala, Thr, or Val

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ala, Ile, Leu, Thr, or Val

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = Ala, Asp, or Gly

<400> 38
Ala Arg Xaa Gly Xaa Xaa Xaa Val Xaa Gly Asp Trp Phe Xaa Tyr
 1               5                  10                  15  


<210> 39
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Gln or Arg

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Asp, Gly, or Ser

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Ile or Val

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Gly, Arg, Ser, or Thr

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Pro, Arg, Ser, or Thr

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ala, Asp, Phe, Ser, Val, or Tyr

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Leu or Val

<220> 
<221> VARIANT        
<222> 11
<223> Xaa = Ala, Gly, or Asn

<400> 39
Xaa Ala Ser Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10      


<210> 40
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = Ala or Asp

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = Asn, Ser, or Thr

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Leu or Arg

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Ala, Glu, or Gln

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Ser or Thr

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ile or Val

<400> 40
Xaa Ala Ser Xaa Xaa Xaa Xaa Gly Xaa
 1               5                  


<210> 41
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Ala, Gly, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Gln, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Ile, Leu, Thr, or Tyr

<220> 
<221> VARIANT        
<222> 9
<223> Xaa = Ile, Ser, Val, or Trp

<400> 41
Tyr Cys Gln Gln Xaa Tyr Xaa Xaa Xaa Thr
 1               5                  10  


<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = Glu or Gln

<220> 
<221> VARIANT        
<222> 5
<223> Xaa = Pro, Ser, or Tyr

<220> 
<221> VARIANT        
<222> 6
<223> Xaa = Asp, Leu, Ser, Thr, or Tyr

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Asp, Glu, His, Ser, or Thr

<220> 
<221> VARIANT        
<222> 8
<223> Xaa = Asp, Leu, Thr, or Trp

<220> 
<221> VARIANT        
<222> 10
<223> Xaa = Leu, Pro, Arg, or Val

<400> 42
Tyr Cys Xaa Gln Xaa Xaa Xaa Xaa Pro Xaa Thr
 1               5                  10      


<210> 43
<211> 163
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 43
Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn
 1               5                  10                  15      
Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser
            20                  25                  30          
Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val
        35                  40                  45              
Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp
    50                  55                  60                  
Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu
65                  70                  75                  80  
Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp
                85                  90                  95      
Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro
            100                 105                 110         
Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr
        115                 120                 125             
Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro
    130                 135                 140                 
Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His
145                 150                 155                 160 
Ser Pro Gln
            


<210> 44
<211> 762
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 44
atggaatacg cctctgacgc ttcactggac cccgaagccc cgtggcctcc cgcgccccgc 60
gctcgcgcct gccgcgtact gccttgggcc ctggtcgcgg ggctgctgct gctgctgctg 120
ctcgctgccg cctgcgccgt cttcctcgcc tgcccctggg ccgtgtccgg ggctcgcgcc 180
tcgcccggct ccgcggccag cccgagactc cgcgagggtc ccgagctttc gcccgacgat 240
cccgccggcc tcttggacct gcggcagggc atgtttgcgc agctggtggc ccaaaatgtt 300
ctgctgatcg atgggcccct gagctggtac agtgacccag gcctggcagg cgtgtccctg 360
acggggggcc tgagctacaa agaggacacg aaggagctgg tggtggccaa ggctggagtc 420
tactatgtct tctttcaact agagctgcgg cgcgtggtgg ccggcgaggg ctcaggctcc 480
gtttcacttg cgctgcacct gcagccactg cgctctgctg ctggggccgc cgccctggct 540
ttgaccgtgg acctgccacc cgcctcctcc gaggctcgga actcggcctt cggtttccag 600
ggccgcttgc tgcacctgag tgccggccag cgcctgggcg tccatcttca cactgaggcc 660
agggcacgcc atgcctggca gcttacccag ggcgccacag tcttgggact cttccgggtg 720
acccccgaaa tcccagccgg actcccttca ccgaggtcgg aa                    762

<210> 45
<211> 254
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 45
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro
 1               5                  10                  15      
Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro Trp Ala Leu Val
            20                  25                  30          
Ala Gly Leu Leu Leu Leu Leu Leu Leu Ala Ala Ala Cys Ala Val Phe
        35                  40                  45              
Leu Ala Cys Pro Trp Ala Val Ser Gly Ala Arg Ala Ser Pro Gly Ser
    50                  55                  60                  
Ala Ala Ser Pro Arg Leu Arg Glu Gly Pro Glu Leu Ser Pro Asp Asp
65                  70                  75                  80  
Pro Ala Gly Leu Leu Asp Leu Arg Gln Gly Met Phe Ala Gln Leu Val
                85                  90                  95      
Ala Gln Asn Val Leu Leu Ile Asp Gly Pro Leu Ser Trp Tyr Ser Asp
            100                 105                 110         
Pro Gly Leu Ala Gly Val Ser Leu Thr Gly Gly Leu Ser Tyr Lys Glu
        115                 120                 125             
Asp Thr Lys Glu Leu Val Val Ala Lys Ala Gly Val Tyr Tyr Val Phe
    130                 135                 140                 
Phe Gln Leu Glu Leu Arg Arg Val Val Ala Gly Glu Gly Ser Gly Ser
145                 150                 155                 160 
Val Ser Leu Ala Leu His Leu Gln Pro Leu Arg Ser Ala Ala Gly Ala
                165                 170                 175     
Ala Ala Leu Ala Leu Thr Val Asp Leu Pro Pro Ala Ser Ser Glu Ala
            180                 185                 190         
Arg Asn Ser Ala Phe Gly Phe Gln Gly Arg Leu Leu His Leu Ser Ala
        195                 200                 205             
Gly Gln Arg Leu Gly Val His Leu His Thr Glu Ala Arg Ala Arg His
    210                 215                 220                 
Ala Trp Gln Leu Thr Gln Gly Ala Thr Val Leu Gly Leu Phe Arg Val
225                 230                 235                 240 
Thr Pro Glu Ile Pro Ala Gly Leu Pro Ser Pro Arg Ser Glu
                245                 250                 


<210> 46
<211> 289
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 46
Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu
 1               5                  10                  15      
Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr
            20                  25                  30          
Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu
        35                  40                  45              
Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile
    50                  55                  60                  
Ile Gln Phe Val His Gly Glu Asp Leu Lys Val Gln His Ser Ser Tyr
65                  70                  75                  80  
Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala
                85                  90                  95      
Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg
            100                 105                 110         
Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys
        115                 120                 125             
Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp
    130                 135                 140                 
Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro
145                 150                 155                 160 
Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly
                165                 170                 175     
Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val
            180                 185                 190         
Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys
        195                 200                 205             
Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val
    210                 215                 220                 
Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His Leu
225                 230                 235                 240 
Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr Phe
                245                 250                 255     
Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys Gly
            260                 265                 270         
Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu Glu
        275                 280                 285             
Thr
    


<210> 47
<211> 3256
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 47
Met Trp Pro Thr Arg Arg Leu Val Thr Ile Lys Arg Ser Gly Val Asp
 1               5                  10                  15      
Gly Pro His Phe Pro Leu Ser Leu Ser Thr Cys Leu Phe Gly Arg Gly
            20                  25                  30          
Ile Glu Cys Asp Ile Arg Ile Gln Leu Pro Val Val Ser Lys Gln His
        35                  40                  45              
Cys Lys Ile Glu Ile His Glu Gln Glu Ala Ile Leu His Asn Phe Ser
    50                  55                  60                  
Ser Thr Asn Pro Thr Gln Val Asn Gly Ser Val Ile Asp Glu Pro Val
65                  70                  75                  80  
Arg Leu Lys His Gly Asp Val Ile Thr Ile Ile Asp Arg Ser Phe Arg
                85                  90                  95      
Tyr Glu Asn Glu Ser Leu Gln Asn Gly Arg Lys Ser Thr Glu Phe Pro
            100                 105                 110         
Arg Lys Ile Arg Glu Gln Glu Pro Ala Arg Arg Val Ser Arg Ser Ser
        115                 120                 125             
Phe Ser Ser Asp Pro Asp Glu Lys Ala Gln Asp Ser Lys Ala Tyr Ser
    130                 135                 140                 
Lys Ile Thr Glu Gly Lys Val Ser Gly Asn Pro Gln Val His Ile Lys
145                 150                 155                 160 
Asn Val Lys Glu Asp Ser Thr Ala Asp Asp Ser Lys Asp Ser Val Ala
                165                 170                 175     
Gln Gly Thr Thr Asn Val His Ser Ser Glu His Ala Gly Arg Asn Gly
            180                 185                 190         
Arg Asn Ala Ala Asp Pro Ile Ser Gly Asp Phe Lys Glu Ile Ser Ser
        195                 200                 205             
Val Lys Leu Val Ser Arg Tyr Gly Glu Leu Lys Ser Val Pro Thr Thr
    210                 215                 220                 
Gln Cys Leu Asp Asn Ser Lys Lys Asn Glu Ser Pro Phe Trp Lys Leu
225                 230                 235                 240 
Tyr Glu Ser Val Lys Lys Glu Leu Asp Val Lys Ser Gln Lys Glu Asn
                245                 250                 255     
Val Leu Gln Tyr Cys Arg Lys Ser Gly Leu Gln Thr Asp Tyr Ala Thr
            260                 265                 270         
Glu Lys Glu Ser Ala Asp Gly Leu Gln Gly Glu Thr Gln Leu Leu Val
        275                 280                 285             
Ser Arg Lys Ser Arg Pro Lys Ser Gly Gly Ser Gly His Ala Val Ala
    290                 295                 300                 
Glu Pro Ala Ser Pro Glu Gln Glu Leu Asp Gln Asn Lys Gly Lys Gly
305                 310                 315                 320 
Arg Asp Val Glu Ser Val Gln Thr Pro Ser Lys Ala Val Gly Ala Ser
                325                 330                 335     
Phe Pro Leu Tyr Glu Pro Ala Lys Met Lys Thr Pro Val Gln Tyr Ser
            340                 345                 350         
Gln Gln Gln Asn Ser Pro Gln Lys His Lys Asn Lys Asp Leu Tyr Thr
        355                 360                 365             
Thr Gly Arg Arg Glu Ser Val Asn Leu Gly Lys Ser Glu Gly Phe Lys
    370                 375                 380                 
Ala Gly Asp Lys Thr Leu Thr Pro Arg Lys Leu Ser Thr Arg Asn Arg
385                 390                 395                 400 
Thr Pro Ala Lys Val Glu Asp Ala Ala Asp Ser Ala Thr Lys Pro Glu
                405                 410                 415     
Asn Leu Ser Ser Lys Thr Arg Gly Ser Ile Pro Thr Asp Val Glu Val
            420                 425                 430         
Leu Pro Thr Glu Thr Glu Ile His Asn Glu Pro Phe Leu Thr Leu Trp
        435                 440                 445             
Leu Thr Gln Val Glu Arg Lys Ile Gln Lys Asp Ser Leu Ser Lys Pro
    450                 455                 460                 
Glu Lys Leu Gly Thr Thr Ala Gly Gln Met Cys Ser Gly Leu Pro Gly
465                 470                 475                 480 
Leu Ser Ser Val Asp Ile Asn Asn Phe Gly Asp Ser Ile Asn Glu Ser
                485                 490                 495     
Glu Gly Ile Pro Leu Lys Arg Arg Arg Val Ser Phe Gly Gly His Leu
            500                 505                 510         
Arg Pro Glu Leu Phe Asp Glu Asn Leu Pro Pro Asn Thr Pro Leu Lys
        515                 520                 525             
Arg Gly Glu Ala Pro Thr Lys Arg Lys Ser Leu Val Met His Thr Pro
    530                 535                 540                 
Pro Val Leu Lys Lys Ile Ile Lys Glu Gln Pro Gln Pro Ser Gly Lys
545                 550                 555                 560 
Gln Glu Ser Gly Ser Glu Ile His Val Glu Val Lys Ala Gln Ser Leu
                565                 570                 575     
Val Ile Ser Pro Pro Ala Pro Ser Pro Arg Lys Thr Pro Val Ala Ser
            580                 585                 590         
Asp Gln Arg Arg Arg Ser Cys Lys Thr Ala Pro Ala Ser Ser Ser Lys
        595                 600                 605             
Ser Gln Thr Glu Val Pro Lys Arg Gly Gly Arg Lys Ser Gly Asn Leu
    610                 615                 620                 
Pro Ser Lys Arg Val Ser Ile Ser Arg Ser Gln His Asp Ile Leu Gln
625                 630                 635                 640 
Met Ile Cys Ser Lys Arg Arg Ser Gly Ala Ser Glu Ala Asn Leu Ile
                645                 650                 655     
Val Ala Lys Ser Trp Ala Asp Val Val Lys Leu Gly Ala Lys Gln Thr
            660                 665                 670         
Gln Thr Lys Val Ile Lys His Gly Pro Gln Arg Ser Met Asn Lys Arg
        675                 680                 685             
Gln Arg Arg Pro Ala Thr Pro Lys Lys Pro Val Gly Glu Val His Ser
    690                 695                 700                 
Gln Phe Ser Thr Gly His Ala Asn Ser Pro Cys Thr Ile Ile Ile Gly
705                 710                 715                 720 
Lys Ala His Thr Glu Lys Val His Val Pro Ala Arg Pro Tyr Arg Val
                725                 730                 735     
Leu Asn Asn Phe Ile Ser Asn Gln Lys Met Asp Phe Lys Glu Asp Leu
            740                 745                 750         
Ser Gly Ile Ala Glu Met Phe Lys Thr Pro Val Lys Glu Gln Pro Gln
        755                 760                 765             
Leu Thr Ser Thr Cys His Ile Ala Ile Ser Asn Ser Glu Asn Leu Leu
    770                 775                 780                 
Gly Lys Gln Phe Gln Gly Thr Asp Ser Gly Glu Glu Pro Leu Leu Pro
785                 790                 795                 800 
Thr Ser Glu Ser Phe Gly Gly Asn Val Phe Phe Ser Ala Gln Asn Ala
                805                 810                 815     
Ala Lys Gln Pro Ser Asp Lys Cys Ser Ala Ser Pro Pro Leu Arg Arg
            820                 825                 830         
Gln Cys Ile Arg Glu Asn Gly Asn Val Ala Lys Thr Pro Arg Asn Thr
        835                 840                 845             
Tyr Lys Met Thr Ser Leu Glu Thr Lys Thr Ser Asp Thr Glu Thr Glu
    850                 855                 860                 
Pro Ser Lys Thr Val Ser Thr Ala Asn Arg Ser Gly Arg Ser Thr Glu
865                 870                 875                 880 
Phe Arg Asn Ile Gln Lys Leu Pro Val Glu Ser Lys Ser Glu Glu Thr
                885                 890                 895     
Asn Thr Glu Ile Val Glu Cys Ile Leu Lys Arg Gly Gln Lys Ala Thr
            900                 905                 910         
Leu Leu Gln Gln Arg Arg Glu Gly Glu Met Lys Glu Ile Glu Arg Pro
        915                 920                 925             
Phe Glu Thr Tyr Lys Glu Asn Ile Glu Leu Lys Glu Asn Asp Glu Lys
    930                 935                 940                 
Met Lys Ala Met Lys Arg Ser Arg Thr Trp Gly Gln Lys Cys Ala Pro
945                 950                 955                 960 
Met Ser Asp Leu Thr Asp Leu Lys Ser Leu Pro Asp Thr Glu Leu Met
                965                 970                 975     
Lys Asp Thr Ala Arg Gly Gln Asn Leu Leu Gln Thr Gln Asp His Ala
            980                 985                 990         
Lys Ala Pro Lys Ser Glu Lys Gly Lys Ile Thr Lys Met Pro Cys Gln
        995                 1000                1005            
Ser Leu Gln Pro Glu Pro Ile Asn Thr Pro Thr His Thr Lys Gln Gln
    1010                1015                1020                
Leu Lys Ala Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu Ala
1025                1030                1035               1040 
Val Gly Lys Phe Thr Arg Thr Ser Gly Glu Thr Thr His Thr His Arg
                1045                1050                1055    
Glu Pro Ala Gly Asp Gly Lys Ser Ile Arg Thr Phe Lys Glu Ser Pro
            1060                1065                1070        
Lys Gln Ile Leu Asp Pro Ala Ala Arg Val Thr Gly Met Lys Lys Trp
        1075                1080                1085            
Pro Arg Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala Gly
    1090                1095                1100                
Phe Lys Glu Leu Phe Gln Thr Pro Gly Pro Ser Glu Glu Ser Met Thr
1105                1110                1115               1120 
Asp Glu Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu Ser
                1125                1130                1135    
Val Asp Thr Pro Thr Ser Thr Lys Gln Trp Pro Lys Arg Ser Leu Arg
            1140                1145                1150        
Lys Ala Asp Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Leu Thr Pro
        1155                1160                1165            
Ser Ala Gly Lys Ala Met Leu Thr Pro Lys Pro Ala Gly Gly Asp Glu
    1170                1175                1180                
Lys Asp Ile Lys Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp Leu
1185                1190                1195               1200 
Ala Gly Thr Leu Pro Gly Ser Lys Arg Gln Leu Gln Thr Pro Lys Glu
                1205                1210                1215    
Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln
            1220                1225                1230        
Thr Pro Gly His Thr Glu Glu Leu Val Ala Ala Gly Lys Thr Thr Lys
        1235                1240                1245            
Ile Pro Cys Asp Ser Pro Gln Ser Asp Pro Val Asp Thr Pro Thr Ser
    1250                1255                1260                
Thr Lys Gln Arg Pro Lys Arg Ser Ile Arg Lys Ala Asp Val Glu Gly
1265                1270                1275               1280 
Glu Leu Leu Ala Cys Arg Asn Leu Met Pro Ser Ala Gly Lys Ala Met
                1285                1290                1295    
His Thr Pro Lys Pro Ser Val Gly Glu Glu Lys Asp Ile Ile Ile Phe
            1300                1305                1310        
Val Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn Leu Thr Gly
        1315                1320                1325            
Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Glu Ala Gln Ala Leu Glu
    1330                1335                1340                
Asp Leu Thr Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr Glu
1345                1350                1355               1360 
Glu Ala Val Ala Ala Gly Lys Thr Thr Lys Met Pro Cys Glu Ser Ser
                1365                1370                1375    
Pro Pro Glu Ser Ala Asp Thr Pro Thr Ser Thr Arg Arg Gln Pro Lys
            1380                1385                1390        
Thr Pro Leu Glu Lys Arg Asp Val Gln Lys Glu Leu Ser Ala Leu Lys
        1395                1400                1405            
Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr Asp Lys Val Pro
    1410                1415                1420                
Gly Gly Glu Asp Lys Ser Ile Asn Ala Phe Arg Glu Thr Ala Lys Gln
1425                1430                1435               1440 
Lys Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Lys Arg His Pro Lys
                1445                1450                1455    
Thr Lys Glu Lys Ala Gln Pro Leu Glu Asp Leu Ala Gly Leu Lys Glu
            1460                1465                1470        
Leu Phe Gln Thr Pro Val Cys Thr Asp Lys Pro Thr Thr His Glu Lys
        1475                1480                1485            
Thr Thr Lys Ile Ala Cys Arg Ser Gln Pro Asp Pro Val Asp Thr Pro
    1490                1495                1500                
Thr Ser Ser Lys Pro Gln Ser Lys Arg Ser Leu Arg Lys Val Asp Val
1505                1510                1515               1520 
Glu Glu Glu Phe Phe Ala Leu Arg Lys Arg Thr Pro Ser Ala Gly Lys
                1525                1530                1535    
Ala Met His Thr Pro Lys Pro Ala Val Ser Gly Glu Lys Asn Ile Tyr
            1540                1545                1550        
Ala Phe Met Gly Thr Pro Val Gln Lys Leu Asp Leu Thr Glu Asn Leu
        1555                1560                1565            
Thr Gly Ser Lys Arg Arg Leu Gln Thr Pro Lys Glu Lys Ala Gln Ala
    1570                1575                1580                
Leu Glu Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Arg Gly His
1585                1590                1595               1600 
Thr Glu Glu Ser Met Thr Asn Asp Lys Thr Ala Lys Val Ala Cys Lys
                1605                1610                1615    
Ser Ser Gln Pro Asp Pro Asp Lys Asn Pro Ala Ser Ser Lys Arg Arg
            1620                1625                1630        
Leu Lys Thr Ser Leu Gly Lys Val Gly Val Lys Glu Glu Leu Leu Ala
        1635                1640                1645            
Val Gly Lys Leu Thr Gln Thr Ser Gly Glu Thr Thr His Thr His Thr
    1650                1655                1660                
Glu Pro Thr Gly Asp Gly Lys Ser Met Lys Ala Phe Met Glu Ser Pro
1665                1670                1675               1680 
Lys Gln Ile Leu Asp Ser Ala Ala Ser Leu Thr Gly Ser Lys Arg Gln
                1685                1690                1695    
Leu Arg Thr Pro Lys Gly Lys Ser Glu Val Pro Glu Asp Leu Ala Gly
            1700                1705                1710        
Phe Ile Glu Leu Phe Gln Thr Pro Ser His Thr Lys Glu Ser Met Thr
        1715                1720                1725            
Asn Glu Lys Thr Thr Lys Val Ser Tyr Arg Ala Ser Gln Pro Asp Leu
    1730                1735                1740                
Val Asp Thr Pro Thr Ser Ser Lys Pro Gln Pro Lys Arg Ser Leu Arg
1745                1750                1755               1760 
Lys Ala Asp Thr Glu Glu Glu Phe Leu Ala Phe Arg Lys Gln Thr Pro
                1765                1770                1775    
Ser Ala Gly Lys Ala Met His Thr Pro Lys Pro Ala Val Gly Glu Glu
            1780                1785                1790        
Lys Asp Ile Asn Thr Phe Leu Gly Thr Pro Val Gln Lys Leu Asp Gln
        1795                1800                1805            
Pro Gly Asn Leu Pro Gly Ser Asn Arg Arg Leu Gln Thr Arg Lys Glu
    1810                1815                1820                
Lys Ala Gln Ala Leu Glu Glu Leu Thr Gly Phe Arg Glu Leu Phe Gln
1825                1830                1835               1840 
Thr Pro Cys Thr Asp Asn Pro Thr Thr Asp Glu Lys Thr Thr Lys Lys
                1845                1850                1855    
Ile Leu Cys Lys Ser Pro Gln Ser Asp Pro Ala Asp Thr Pro Thr Asn
            1860                1865                1870        
Thr Lys Gln Arg Pro Lys Arg Ser Leu Lys Lys Ala Asp Val Glu Glu
        1875                1880                1885            
Glu Phe Leu Ala Phe Arg Lys Leu Thr Pro Ser Ala Gly Lys Ala Met
    1890                1895                1900                
His Thr Pro Lys Ala Ala Val Gly Glu Glu Lys Asp Ile Asn Thr Phe
1905                1910                1915               1920 
Val Gly Thr Pro Val Glu Lys Leu Asp Leu Leu Gly Asn Leu Pro Gly
                1925                1930                1935    
Ser Lys Arg Arg Pro Gln Thr Pro Lys Glu Lys Ala Lys Ala Leu Glu
            1940                1945                1950        
Asp Leu Ala Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly His Thr Glu
        1955                1960                1965            
Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser Cys Lys Ser Pro
    1970                1975                1980                
Gln Pro Asp Pro Val Lys Thr Pro Thr Ser Ser Lys Gln Arg Leu Lys
1985                1990                1995               2000 
Ile Ser Leu Gly Lys Val Gly Val Lys Glu Glu Val Leu Pro Val Gly
                2005                2010                2015    
Lys Leu Thr Gln Thr Ser Gly Lys Thr Thr Gln Thr His Arg Glu Thr
            2020                2025                2030        
Ala Gly Asp Gly Lys Ser Ile Lys Ala Phe Lys Glu Ser Ala Lys Gln
        2035                2040                2045            
Met Leu Asp Pro Ala Asn Tyr Gly Thr Gly Met Glu Arg Trp Pro Arg
    2050                2055                2060                
Thr Pro Lys Glu Glu Ala Gln Ser Leu Glu Asp Leu Ala Gly Phe Lys
2065                2070                2075               2080 
Glu Leu Phe Gln Thr Pro Asp His Thr Glu Glu Ser Thr Thr Asp Asp
                2085                2090                2095    
Lys Thr Thr Lys Ile Ala Cys Lys Ser Pro Pro Pro Glu Ser Met Asp
            2100                2105                2110        
Thr Pro Thr Ser Thr Arg Arg Arg Pro Lys Thr Pro Leu Gly Lys Arg
        2115                2120                2125            
Asp Ile Val Glu Glu Leu Ser Ala Leu Lys Gln Leu Thr Gln Thr Thr
    2130                2135                2140                
His Thr Asp Lys Val Pro Gly Asp Glu Asp Lys Gly Ile Asn Val Phe
2145                2150                2155               2160 
Arg Glu Thr Ala Lys Gln Lys Leu Asp Pro Ala Ala Ser Val Thr Gly
                2165                2170                2175    
Ser Lys Arg Gln Pro Arg Thr Pro Lys Gly Lys Ala Gln Pro Leu Glu
            2180                2185                2190        
Asp Leu Ala Gly Leu Lys Glu Leu Phe Gln Thr Pro Ile Cys Thr Asp
        2195                2200                2205            
Lys Pro Thr Thr His Glu Lys Thr Thr Lys Ile Ala Cys Arg Ser Pro
    2210                2215                2220                
Gln Pro Asp Pro Val Gly Thr Pro Thr Ile Phe Lys Pro Gln Ser Lys
2225                2230                2235               2240 
Arg Ser Leu Arg Lys Ala Asp Val Glu Glu Glu Ser Leu Ala Leu Arg
                2245                2250                2255    
Lys Arg Thr Pro Ser Val Gly Lys Ala Met Asp Thr Pro Lys Pro Ala
            2260                2265                2270        
Gly Gly Asp Glu Lys Asp Met Lys Ala Phe Met Gly Thr Pro Val Gln
        2275                2280                2285            
Lys Leu Asp Leu Pro Gly Asn Leu Pro Gly Ser Lys Arg Trp Pro Gln
    2290                2295                2300                
Thr Pro Lys Glu Lys Ala Gln Ala Leu Glu Asp Leu Ala Gly Phe Lys
2305                2310                2315               2320 
Glu Leu Phe Gln Thr Pro Gly Thr Asp Lys Pro Thr Thr Asp Glu Lys
                2325                2330                2335    
Thr Thr Lys Ile Ala Cys Lys Ser Pro Gln Pro Asp Pro Val Asp Thr
            2340                2345                2350        
Pro Ala Ser Thr Lys Gln Arg Pro Lys Arg Asn Leu Arg Lys Ala Asp
        2355                2360                2365            
Val Glu Glu Glu Phe Leu Ala Leu Arg Lys Arg Thr Pro Ser Ala Gly
    2370                2375                2380                
Lys Ala Met Asp Thr Pro Lys Pro Ala Val Ser Asp Glu Lys Asn Ile
2385                2390                2395               2400 
Asn Thr Phe Val Glu Thr Pro Val Gln Lys Leu Asp Leu Leu Gly Asn
                2405                2410                2415    
Leu Pro Gly Ser Lys Arg Gln Pro Gln Thr Pro Lys Glu Lys Ala Glu
            2420                2425                2430        
Ala Leu Glu Asp Leu Val Gly Phe Lys Glu Leu Phe Gln Thr Pro Gly
        2435                2440                2445            
His Thr Glu Glu Ser Met Thr Asp Asp Lys Ile Thr Glu Val Ser Cys
    2450                2455                2460                
Lys Ser Pro Gln Pro Glu Ser Phe Lys Thr Ser Arg Ser Ser Lys Gln
2465                2470                2475               2480 
Arg Leu Lys Ile Pro Leu Val Lys Val Asp Met Lys Glu Glu Pro Leu
                2485                2490                2495    
Ala Val Ser Lys Leu Thr Arg Thr Ser Gly Glu Thr Thr Gln Thr His
            2500                2505                2510        
Thr Glu Pro Thr Gly Asp Ser Lys Ser Ile Lys Ala Phe Lys Glu Ser
        2515                2520                2525            
Pro Lys Gln Ile Leu Asp Pro Ala Ala Ser Val Thr Gly Ser Arg Arg
    2530                2535                2540                
Gln Leu Arg Thr Arg Lys Glu Lys Ala Arg Ala Leu Glu Asp Leu Val
2545                2550                2555               2560 
Asp Phe Lys Glu Leu Phe Ser Ala Pro Gly His Thr Glu Glu Ser Met
                2565                2570                2575    
Thr Ile Asp Lys Asn Thr Lys Ile Pro Cys Lys Ser Pro Pro Pro Glu
            2580                2585                2590        
Leu Thr Asp Thr Ala Thr Ser Thr Lys Arg Cys Pro Lys Thr Arg Pro
        2595                2600                2605            
Arg Lys Glu Val Lys Glu Glu Leu Ser Ala Val Glu Arg Leu Thr Gln
    2610                2615                2620                
Thr Ser Gly Gln Ser Thr His Thr His Lys Glu Pro Ala Ser Gly Asp
2625                2630                2635               2640 
Glu Gly Ile Lys Val Leu Lys Gln Arg Ala Lys Lys Lys Pro Asn Pro
                2645                2650                2655    
Val Glu Glu Glu Pro Ser Arg Arg Arg Pro Arg Ala Pro Lys Glu Lys
            2660                2665                2670        
Ala Gln Pro Leu Glu Asp Leu Ala Gly Phe Thr Glu Leu Ser Glu Thr
        2675                2680                2685            
Ser Gly His Thr Gln Glu Ser Leu Thr Ala Gly Lys Ala Thr Lys Ile
    2690                2695                2700                
Pro Cys Glu Ser Pro Pro Leu Glu Val Val Asp Thr Thr Ala Ser Thr
2705                2710                2715               2720 
Lys Arg His Leu Arg Thr Arg Val Gln Lys Val Gln Val Lys Glu Glu
                2725                2730                2735    
Pro Ser Ala Val Lys Phe Thr Gln Thr Ser Gly Glu Thr Thr Asp Ala
            2740                2745                2750        
Asp Lys Glu Pro Ala Gly Glu Asp Lys Gly Ile Lys Ala Leu Lys Glu
        2755                2760                2765            
Ser Ala Lys Gln Thr Pro Ala Pro Ala Ala Ser Val Thr Gly Ser Arg
    2770                2775                2780                
Arg Arg Pro Arg Ala Pro Arg Glu Ser Ala Gln Ala Ile Glu Asp Leu
2785                2790                2795               2800 
Ala Gly Phe Lys Asp Pro Ala Ala Gly His Thr Glu Glu Ser Met Thr
                2805                2810                2815    
Asp Asp Lys Thr Thr Lys Ile Pro Cys Lys Ser Ser Pro Glu Leu Glu
            2820                2825                2830        
Asp Thr Ala Thr Ser Ser Lys Arg Arg Pro Arg Thr Arg Ala Gln Lys
        2835                2840                2845            
Val Glu Val Lys Glu Glu Leu Leu Ala Val Gly Lys Leu Thr Gln Thr
    2850                2855                2860                
Ser Gly Glu Thr Thr His Thr Asp Lys Glu Pro Val Gly Glu Gly Lys
2865                2870                2875               2880 
Gly Thr Lys Ala Phe Lys Gln Pro Ala Lys Arg Lys Leu Asp Ala Glu
                2885                2890                2895    
Asp Val Ile Gly Ser Arg Arg Gln Pro Arg Ala Pro Lys Glu Lys Ala
            2900                2905                2910        
Gln Pro Leu Glu Asp Leu Ala Ser Phe Gln Glu Leu Ser Gln Thr Pro
        2915                2920                2925            
Gly His Thr Glu Glu Leu Ala Asn Gly Ala Ala Asp Ser Phe Thr Ser
    2930                2935                2940                
Ala Pro Lys Gln Thr Pro Asp Ser Gly Lys Pro Leu Lys Ile Ser Arg
2945                2950                2955               2960 
Arg Val Leu Arg Ala Pro Lys Val Glu Pro Val Gly Asp Val Val Ser
                2965                2970                2975    
Thr Arg Asp Pro Val Lys Ser Gln Ser Lys Ser Asn Thr Ser Leu Pro
            2980                2985                2990        
Pro Leu Pro Phe Lys Arg Gly Gly Gly Lys Asp Gly Ser Val Thr Gly
        2995                3000                3005            
Thr Lys Arg Leu Arg Cys Met Pro Ala Pro Glu Glu Ile Val Glu Glu
    3010                3015                3020                
Leu Pro Ala Ser Lys Lys Gln Arg Val Ala Pro Arg Ala Arg Gly Lys
3025                3030                3035               3040 
Ser Ser Glu Pro Val Val Ile Met Lys Arg Ser Leu Arg Thr Ser Ala
                3045                3050                3055    
Lys Arg Ile Glu Pro Ala Glu Glu Leu Asn Ser Asn Asp Met Lys Thr
            3060                3065                3070        
Asn Lys Glu Glu His Lys Leu Gln Asp Ser Val Pro Glu Asn Lys Gly
        3075                3080                3085            
Ile Ser Leu Arg Ser Arg Arg Gln Asn Lys Thr Glu Ala Glu Gln Gln
    3090                3095                3100                
Ile Thr Glu Val Phe Val Leu Ala Glu Arg Ile Glu Ile Asn Arg Asn
3105                3110                3115               3120 
Glu Lys Lys Pro Met Lys Thr Ser Pro Glu Met Asp Ile Gln Asn Pro
                3125                3130                3135    
Asp Asp Gly Ala Arg Lys Pro Ile Pro Arg Asp Lys Val Thr Glu Asn
            3140                3145                3150        
Lys Arg Cys Leu Arg Ser Ala Arg Gln Asn Glu Ser Ser Gln Pro Lys
        3155                3160                3165            
Val Ala Glu Glu Ser Gly Gly Gln Lys Ser Ala Lys Val Leu Met Gln
    3170                3175                3180                
Asn Gln Lys Gly Lys Gly Glu Ala Gly Asn Ser Asp Ser Met Cys Leu
3185                3190                3195               3200 
Arg Ser Arg Lys Thr Lys Ser Gln Pro Ala Ala Ser Thr Leu Glu Ser
                3205                3210                3215    
Lys Ser Val Gln Arg Val Thr Arg Ser Val Lys Arg Cys Ala Glu Asn
            3220                3225                3230        
Pro Lys Lys Ala Glu Asp Asn Val Cys Val Lys Lys Ile Arg Thr Arg
        3235                3240                3245            
Ser His Arg Asp Ser Glu Asp Ile
    3250                3255    


<210> 48
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 48
Tyr Ser Ile Ser Ser Gly Tyr His Trp Ser Trp Ile
 1               5                  10          


<210> 49
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 49
Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 50
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 50
Ala Arg Ser Tyr Val Tyr Phe Asp Tyr
 1               5                  


<210> 51
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 51
Arg Ala Ser Gln Ser Val Arg Gly Arg Phe Leu Ala
 1               5                  10          


<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 52
Asp Ala Ser Asn Arg Ala Thr Gly Ile
 1               5                  


<210> 53
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 53
Tyr Cys Gln Gln Ser Ser Ser Trp Pro Pro Thr
 1               5                  10      


<210> 54
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 54
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Ser Ile Ser Ser Gly
            20                  25                  30          
Tyr His Trp Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp
        35                  40                  45              
Leu Ala Arg Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser Leu
    50                  55                  60                  
Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ser Tyr Val Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 55
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 55
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Arg Gly Arg
            20                  25                  30          
Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Ser Ser Trp Pro
                85                  90                  95      
Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105                 


<210> 56
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 56
Gly Phe Thr Phe Ser Asp Ser Trp Ile His
 1               5                  10  


<210> 57
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 57
Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys
 1               5                  10                  15      
Gly
    


<210> 58
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 58
Arg His Trp Pro Gly Gly Phe Asp Tyr
 1               5                  


<210> 59
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 59
Arg Ala Ser Gln Asp Val Ser Thr Ala Val Ala
 1               5                  10      


<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 60
Ser Ala Ser Phe Leu Tyr Ser
 1               5          


<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 61
Gln Gln Tyr Leu Tyr His Pro Ala Thr
 1               5                  


<210> 62
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 62
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
            20                  25                  30          
Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110         
Leu Val Thr Val Ser Ser
        115             


<210> 63
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 63
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val
            100                 105                 110 


<210> 64
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 64
Thr Tyr Tyr Ile Ser
 1               5  


<210> 65
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 65
Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe Lys
 1               5                  10                  15      


<210> 66
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 66
Ile Gly Tyr Phe Asp Tyr
 1               5      


<210> 67
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 67
Arg Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Gly Thr Tyr Leu Tyr
 1               5                  10                  15      


<210> 68
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 68
Leu Val Ser Thr Leu Gly Ser
 1               5          


<210> 69
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 69
Met Gln Leu Thr His Trp Pro Tyr Thr
 1               5                  


<210> 70
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 70
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Thr Phe Thr Thr Tyr
            20                  25                  30          
Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Tyr Leu
        35                  40                  45              
Gly Tyr Ile Asn Met Gly Ser Gly Gly Thr Asn Tyr Asn Glu Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Ile Ile Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr
            100                 105                 110         
Val Ser Ser
        115 


<210> 71
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 71
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu Asp Ser
            20                  25                  30          
Asp Gly Gly Thr Tyr Leu Tyr Trp Phe Gln Gln Arg Pro Gly Gln Ser
        35                  40                  45              
Pro Arg Arg Leu Ile Tyr Leu Val Ser Thr Leu Gly Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Leu
                85                  90                  95      
Thr His Trp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         


<210> 72
<211> 28
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 72
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro
 1               5                  10                  15      
Pro Ala Pro Arg Ala Arg Ala Cys Arg Val Leu Pro
            20                  25              


<210> 73
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 73
Met Glu Tyr Ala Ser Asp Ala Ser Leu Asp Pro Glu Ala Pro Trp Pro
 1               5                  10                  15      
Pro Ala Pro Arg Ala Arg Ala
            20              


<210> 74
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 74
Phe Ser Leu Ser Thr Ser Gly Val Gly Val Ser Trp Ile
 1               5                  10              


<210> 75
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 75
Leu Ala Leu Ile Asp Trp Ala Gly Asp Lys Tyr Tyr Ser Pro Ser Leu
 1               5                  10                  15      
Lys Ser Arg Leu
            20  


<210> 76
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 76
Ala Arg Tyr Gly Tyr Ser Ser Tyr Ala Leu Asp Tyr
 1               5                  10          


<210> 77
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 77
Arg Ala Ser Gln Ser Val Arg Gly Ser Tyr Leu Ala
 1               5                  10          


<210> 78
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 78
Ala Ala Ser Thr Leu Gln Ser Gly Val
 1               5                  


<210> 79
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 79
Tyr Cys Gln Gln Tyr Ser Ser Leu Trp Thr
 1               5                  10  


<210> 80
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 80
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Ser Thr Ser
            20                  25                  30          
Gly Val Gly Val Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Leu Ala Leu Ile Asp Trp Ala Gly Asp Lys Tyr Tyr Ser Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Tyr Gly Tyr Ser Ser Tyr Ala Leu Asp Tyr Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 81
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 81
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Arg Gly Ser
            20                  25                  30          
Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser
    50                  55                  60                  
Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln
65                  70                  75                  80  
Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Leu Trp
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
            100                 105             


<210> 82
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 82
Asp Tyr Glu Met His
 1               5  


<210> 83
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 83
Val Ile Glu Ser Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe Lys
 1               5                  10                  15      
Gly
    


<210> 84
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 84
Glu Gly Ile Thr Thr Val Ala Thr Thr Tyr Tyr Trp Tyr Phe Asp Val
 1               5                  10                  15      


<210> 85
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 85
Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu
 1               5                  10                  15      


<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 86
Lys Val Ser Asn Arg Phe Ser
 1               5          


<210> 87
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 87
Phe Gln Gly Ser His Val Pro Leu Thr
 1               5                  


<210> 88
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 88
Gln Gly Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala
 1               5                  10                  15      
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
            20                  25                  30          
Glu Met His Trp Val Arg Gln Ala Pro Ile His Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Val Ile Glu Ser Glu Thr Gly Gly Thr Ala Tyr Asn Gln Lys Phe
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Glu Gly Ile Thr Thr Val Ala Thr Thr Tyr Tyr Trp Tyr Phe
            100                 105                 110         
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120                 125 


<210> 89
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Construct

<400> 89
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Leu Gly
 1               5                  10                  15      
Gln Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly
                85                  90                  95      
Ser His Val Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110         

