﻿                         序列表

<110>  正大天晴药业集团股份有限公司

<120>  ST2抗原结合蛋白

<130>  6291-2143480IB

<150>  CN202010397572.3
<151>  2020-05-12

<160>  86

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  556
<212>  PRT
<213>  智人(Homo sapiens)

<220>
<221>  UNSURE
<222>  (78)
<223>  X is E or A


<400>  1
Met Gly Phe Trp Ile Leu Ala Ile Leu Thr Ile Leu Met Tyr Ser Thr 
1               5                   10                  15      
Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          
Ile Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp 
        35                  40                  45              
Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  
Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Xaa Val Ala 
65                  70                  75                  80  
Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      
Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn 
            100                 105                 110         
Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             
Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 
Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg 
145                 150                 155                 160 
Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala 
                165                 170                 175     
Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         
Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             
Ser Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu 
    210                 215                 220                 
Val Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 
Lys Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr 
                245                 250                 255     
Lys Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         
Asn Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg 
        275                 280                 285             
Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu 
    290                 295                 300                 
Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg 
305                 310                 315                 320 
Lys Asn Pro Ile Asp His His Ser Ile Tyr Cys Ile Ile Ala Val Cys 
                325                 330                 335     
Ser Val Phe Leu Met Leu Ile Asn Val Leu Val Ile Ile Leu Lys Met 
            340                 345                 350         
Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala Lys Pro Tyr 
        355                 360                 365             
Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val Val Tyr Pro 
    370                 375                 380                 
Arg Asn Tyr Lys Ser Ser Thr Asp Gly Ala Ser Arg Val Glu His Phe 
385                 390                 395                 400 
Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Thr 
                405                 410                 415     
Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp Val Val Thr 
            420                 425                 430         
Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile Phe Ile Leu 
        435                 440                 445             
Thr Pro Gln Ile Thr His Asn Lys Glu Phe Ala Tyr Glu Gln Glu Val 
    450                 455                 460                 
Ala Leu His Cys Ala Leu Ile Gln Asn Asp Ala Lys Val Ile Leu Ile 
465                 470                 475                 480 
Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala Glu Ala Leu 
                485                 490                 495     
Gln Asp Ser Leu Gln His Leu Met Lys Val Gln Gly Thr Ile Lys Trp 
            500                 505                 510         
Arg Glu Asp His Ile Ala Asn Lys Arg Ser Leu Asn Ser Lys Phe Trp 
        515                 520                 525             
Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Ile Pro Arg Lys 
    530                 535                 540                 
Ala Ser Ser Leu Thr Pro Leu Ala Ala Gln Lys Gln 
545                 550                 555     

<210>  2
<211>  566
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  hST2-ECD-mFc


<400>  2
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Gly Val His 
1               5                   10                  15      
Ser Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu Ile 
            20                  25                  30          
Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp Tyr 
        35                  40                  45              
Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg Val 
    50                  55                  60                  
Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala Asp 
65                  70                  75                  80  
Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg Thr 
                85                  90                  95      
Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn Val 
            100                 105                 110         
Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn Ser 
        115                 120                 125             
Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro Leu 
    130                 135                 140                 
Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg Ala 
145                 150                 155                 160 
His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala Gly 
                165                 170                 175     
Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser 
            180                 185                 190         
Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe Ser 
        195                 200                 205             
Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu Val 
    210                 215                 220                 
Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly Lys 
225                 230                 235                 240 
Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr Lys 
                245                 250                 255     
Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln Asn 
            260                 265                 270         
Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg Ile 
        275                 280                 285             
Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu Ala 
    290                 295                 300                 
Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg Lys 
305                 310                 315                 320 
Asn Pro Ile Asp His His Ser Ile Glu Gly Arg Met Asp Glu Pro Arg 
                325                 330                 335     
Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn 
            340                 345                 350         
Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
        355                 360                 365             
Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp 
    370                 375                 380                 
Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn 
385                 390                 395                 400 
Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
                405                 410                 415     
Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
            420                 425                 430         
Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro 
        435                 440                 445             
Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala 
    450                 455                 460                 
Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys 
465                 470                 475                 480 
Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile 
                485                 490                 495     
Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn 
            500                 505                 510         
Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
        515                 520                 525             
Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys 
    530                 535                 540                 
Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe 
545                 550                 555                 560 
Ser Arg Thr Pro Gly Lys 
                565     

<210>  3
<211>  1650
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  hST2-ECD-mFc


<400>  3
aagttttcta agcagtcctg gggcctggag aacgaggctc tgatcgtgag atgtccccgc        60
cagggcaagc ctagctacac agtggactgg tactatagcc agaccaacaa gtctatccca       120
acacaggaga gaaatcgcgt gttcgcctct ggccagctgc tgaagtttct gcccgccgct       180
gtggctgata gcggcatcta tacctgcatc gtgagatctc ctaccttcaa ccgcacaggc       240
tacgccaatg tgacaatcta taagaagcag tccgactgta acgtgcccga ttacctgatg       300
tattccaccg tgtccggcag cgagaagaat agcaagatct actgccctac catcgacctg       360
tataactgga cagccccact ggagtggttc aagaattgtc aggccctgca gggctctagg       420
taccgggctc acaagtcctt cctggtcatc gataacgtga tgaccgagga cgctggcgat       480
tacacatgca agttcatcca taacgagaat ggcgccaatt attccgtgac cgctacaagg       540
agctttacag tgaaggacga gcagggcttc tccctgtttc cagtgatcgg cgcccccgct       600
cagaacgaga tcaaggaggt ggagatcggc aagaacgcca atctgacctg ctccgcctgt       660
ttcggcaagg gcacacagtt tctggccgct gtgctgtggc agctgaatgg caccaagatc       720
acagatttcg gcgagcctag gatccagcag gaggagggcc agaaccagtc tttttccaat       780
ggactggctt gcctggacat ggtgctgagg atcgctgacg tgaaggagga ggatctgctg       840
ctgcagtatg attgtctggc tctgaacctg cacggcctga ggcggcatac cgtgaggctg       900
tctcggaaga atccaatcga ccaccattcc atcgagggaa ggatggatga gccaaggggc       960
ccaaccatca agccatgccc cccttgcaag tgtcctgctc caaacctgct gggcggccct      1020
tccgtgttca tctttccacc caagatcaag gacgtgctga tgatctctct gtcccctatc      1080
gtgacatgcg tggtggtgga cgtgtctgag gacgatccag atgtgcagat ctcctggttc      1140
gtgaacaatg tggaggtgca caccgcccag acccagacac atagggagga ttacaattcc      1200
acactgaggg tggtgtccgc cctgccaatc cagcatcagg actggatgtc cggcaaggag      1260
tttaagtgca aggtgaacaa taaggatctg cccgccccta tcgagaggac catcagcaag      1320
cccaagggct ctgtgcgggc tcctcaggtg tatgtgctgc ctccacccga ggaggagatg      1380
accaagaagc aggtgaccct gacatgtatg gtgacagact tcatgccaga ggatatctac      1440
gtggagtgga ccaacaatgg caagacagag ctgaactata agaataccga gcccgtgctg      1500
gactccgatg gcagctactt tatgtatagc aagctgagag tggagaagaa gaactgggtg      1560
gagcgcaata gctactcttg ttccgtggtg cacgagggcc tgcataacca ccataccaca      1620
aagagctttt ctcggacacc tggcaagtga                                       1650

<210>  4
<211>  565
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  hST2-ECD-hFc


<400>  4
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Gly Val His 
1               5                   10                  15      
Ser Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu Ile 
            20                  25                  30          
Val Arg Cys Pro Arg Gln Gly Lys Pro Ser Tyr Thr Val Asp Trp Tyr 
        35                  40                  45              
Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg Val 
    50                  55                  60                  
Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Ala Val Ala Asp 
65                  70                  75                  80  
Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg Thr 
                85                  90                  95      
Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Ser Asp Cys Asn Val 
            100                 105                 110         
Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn Ser 
        115                 120                 125             
Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro Leu 
    130                 135                 140                 
Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Arg Ala 
145                 150                 155                 160 
His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Glu Asp Ala Gly 
                165                 170                 175     
Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr Ser 
            180                 185                 190         
Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe Ser 
        195                 200                 205             
Leu Phe Pro Val Ile Gly Ala Pro Ala Gln Asn Glu Ile Lys Glu Val 
    210                 215                 220                 
Glu Ile Gly Lys Asn Ala Asn Leu Thr Cys Ser Ala Cys Phe Gly Lys 
225                 230                 235                 240 
Gly Thr Gln Phe Leu Ala Ala Val Leu Trp Gln Leu Asn Gly Thr Lys 
                245                 250                 255     
Ile Thr Asp Phe Gly Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln Asn 
            260                 265                 270         
Gln Ser Phe Ser Asn Gly Leu Ala Cys Leu Asp Met Val Leu Arg Ile 
        275                 280                 285             
Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Gln Tyr Asp Cys Leu Ala 
    290                 295                 300                 
Leu Asn Leu His Gly Leu Arg Arg His Thr Val Arg Leu Ser Arg Lys 
305                 310                 315                 320 
Asn Pro Ile Asp His His Ser Ile Glu Gly Arg Met Asp Glu Pro Lys 
                325                 330                 335     
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
            340                 345                 350         
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
        355                 360                 365             
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
    370                 375                 380                 
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
385                 390                 395                 400 
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
                405                 410                 415     
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
            420                 425                 430         
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
        435                 440                 445             
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
    450                 455                 460                 
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
465                 470                 475                 480 
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
                485                 490                 495     
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
            500                 505                 510         
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
        515                 520                 525             
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
    530                 535                 540                 
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
545                 550                 555                 560 
Leu Ser Pro Gly Lys 
                565 

<210>  5
<211>  1647
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  hST2-ECD-hFc


<400>  5
aagttttcta agcagtcctg gggcctggag aacgaggctc tgatcgtgag atgtccccgc        60
cagggcaagc ctagctacac agtggactgg tactatagcc agaccaacaa gtctatccca       120
acacaggaga gaaatcgcgt gttcgcctct ggccagctgc tgaagtttct gcccgccgct       180
gtggctgata gcggcatcta tacctgcatc gtgagatctc ctaccttcaa ccgcacaggc       240
tacgccaatg tgacaatcta taagaagcag tccgactgta acgtgcccga ttacctgatg       300
tattccaccg tgtccggcag cgagaagaat agcaagatct actgccctac catcgacctg       360
tataactgga cagccccact ggagtggttc aagaattgtc aggccctgca gggctctagg       420
taccgggctc acaagtcctt cctggtcatc gataacgtga tgaccgagga cgctggcgat       480
tacacatgca agttcatcca taacgagaat ggcgccaatt attccgtgac cgctacaagg       540
agctttacag tgaaggacga gcagggcttc tccctgtttc cagtgatcgg cgcccccgct       600
cagaacgaga tcaaggaggt ggagatcggc aagaacgcca atctgacctg ctccgcctgt       660
ttcggcaagg gcacacagtt tctggccgct gtgctgtggc agctgaatgg caccaagatc       720
acagatttcg gcgagcctag gatccagcag gaggagggcc agaaccagtc tttttccaat       780
ggactggctt gcctggacat ggtgctgagg atcgctgacg tgaaggagga ggatctgctg       840
ctgcagtatg attgtctggc tctgaacctg cacggcctga ggcggcatac cgtgaggctg       900
tctcggaaga atccaatcga ccaccattcc atcgagggaa ggatggatga gccaaagtct       960
tgtgataaga cccatacatg ccccccttgt cctgctccag agctgctggg aggaccatcc      1020
gtgttcctgt ttccacccaa gcccaaggac accctgatga tctcccgcac accagaggtg      1080
acctgcgtgg tggtggacgt gagccacgag gatcccgagg tgaagtttaa ctggtacgtg      1140
gatggcgtgg aggtgcataa tgctaagacc aagccaagag aggagcagta taacagcaca      1200
taccgcgtgg tgtctgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac      1260
aagtgcaagg tgtctaataa ggccctgccc gctcctatcg agaagacaat ctccaaggcc      1320
aagggccagc ctagggagcc acaggtgtat accctgcctc catctcggga cgagctgaca      1380
aagaaccagg tgtccctgac ctgtctggtg aagggcttct accccagcga tatcgctgtg      1440
gagtgggagt ctaatggcca gcctgagaac aattataaga ccacaccccc tgtgctggac      1500
agcgatggct ctttctttct gtactctaag ctgacagtgg ataagtccag gtggcagcag      1560
ggcaacgtgt ttagctgctc tgtgatgcat gaggctctgc acaatcatta cacccagaag      1620
tccctgagcc tgtctcccgg caagtga                                          1647

<210>  6
<211>  174
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  hIL33 Avitag


<400>  6
Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser 
1               5                   10                  15      
Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr 
            20                  25                  30          
Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val 
        35                  40                  45              
Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp 
    50                  55                  60                  
Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp 
65                  70                  75                  80  
Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys 
                85                  90                  95      
Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met 
            100                 105                 110         
His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe 
        115                 120                 125             
Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser 
    130                 135                 140                 
Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr Gly 
145                 150                 155                 160 
Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
                165                 170                 

<210>  7
<211>  525
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  hIL33 Avitag


<400>  7
agcataacag gaatatcacc cataactgaa tatctagctt cattaagtac atataacgat        60
cagagcatta ccttcgcgct ggaggacgaa agctacgaga tctatgtgga agacctgaag       120
aaagatgaaa agaaagacaa ggttctgctg agctactatg agagccaaca cccgagcaac       180
gaaagcggtg acggcgtgga tggcaaaatg ctgatggtta ccctgagccc gaccaaggac       240
ttttggctgc acgcgaacaa caaagagcac agcgtggaac tgcacaagtg cgagaaaccg       300
ctgccggatc aggcgttctt tgtgctgcac aacatgcaca gcaactgcgt tagcttcgaa       360
tgcaagaccg atccgggtgt gtttattggc gttaaggaca accacctggc gctgatcaaa       420
gttgatagca gcgagaacct gtgcaccgaa aacattctgt tcaagctgag cgagaccggt       480
ctgaacgaca tttttgaagc gcaaaaaatc gagtggcacg aataa                       525

<210>  8
<211>  159
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  hIL33蛋白


<400>  8
Ser Ile Thr Gly Ile Ser Pro Ile Thr Glu Tyr Leu Ala Ser Leu Ser 
1               5                   10                  15      
Thr Tyr Asn Asp Gln Ser Ile Thr Phe Ala Leu Glu Asp Glu Ser Tyr 
            20                  25                  30          
Glu Ile Tyr Val Glu Asp Leu Lys Lys Asp Glu Lys Lys Asp Lys Val 
        35                  40                  45              
Leu Leu Ser Tyr Tyr Glu Ser Gln His Pro Ser Asn Glu Ser Gly Asp 
    50                  55                  60                  
Gly Val Asp Gly Lys Met Leu Met Val Thr Leu Ser Pro Thr Lys Asp 
65                  70                  75                  80  
Phe Trp Leu His Ala Asn Asn Lys Glu His Ser Val Glu Leu His Lys 
                85                  90                  95      
Cys Glu Lys Pro Leu Pro Asp Gln Ala Phe Phe Val Leu His Asn Met 
            100                 105                 110         
His Ser Asn Cys Val Ser Phe Glu Cys Lys Thr Asp Pro Gly Val Phe 
        115                 120                 125             
Ile Gly Val Lys Asp Asn His Leu Ala Leu Ile Lys Val Asp Ser Ser 
    130                 135                 140                 
Glu Asn Leu Cys Thr Glu Asn Ile Leu Phe Lys Leu Ser Glu Thr 
145                 150                 155                 

<210>  9
<211>  477
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  hIL33蛋白


<400>  9
agcataacag gaatatcacc cataactgaa tatctagctt cattaagtac atataacgat        60
cagagcatta ccttcgcgct ggaggacgaa agctacgaga tctatgtgga agacctgaag       120
aaagatgaaa agaaagacaa ggttctgctg agctactatg agagccaaca cccgagcaac       180
gaaagcggtg acggcgtgga tggcaaaatg ctgatggtta ccctgagccc gaccaaggac       240
ttttggctgc acgcgaacaa caaagagcac agcgtggaac tgcacaagtg cgagaaaccg       300
ctgccggatc aggcgttctt tgtgctgcac aacatgcaca gcaactgcgt tagcttcgaa       360
tgcaagaccg atccgggtgt gtttattggc gttaaggaca accacctggc gctgatcaaa       420
gttgatagca gcgagaacct gtgcaccgaa aacattctgt tcaagctgag cgagacc          477

<210>  10
<211>  556
<212>  PRT
<213>  食蟹猴(Macaca fascicularis)

<400>  10
Met Gly Leu Trp Ile Leu Ala Ile Leu Thr Ile Leu Val Tyr Ser Thr 
1               5                   10                  15      
Ala Ala Lys Phe Ser Lys Gln Ser Trp Gly Leu Glu Asn Glu Ala Leu 
            20                  25                  30          
Ile Val Arg Cys Pro Arg Gln Gly Lys Ser Ser Tyr Ile Val Asp Trp 
        35                  40                  45              
Tyr Tyr Ser Gln Thr Asn Lys Ser Ile Pro Thr Gln Glu Arg Asn Arg 
    50                  55                  60                  
Val Phe Ala Ser Gly Gln Leu Leu Lys Phe Leu Pro Ala Glu Val Ala 
65                  70                  75                  80  
Asp Ser Gly Ile Tyr Thr Cys Ile Val Arg Ser Pro Thr Phe Asn Arg 
                85                  90                  95      
Thr Gly Tyr Ala Asn Val Thr Ile Tyr Lys Lys Gln Pro Asp Cys Asn 
            100                 105                 110         
Val Pro Asp Tyr Leu Met Tyr Ser Thr Val Ser Gly Ser Glu Lys Asn 
        115                 120                 125             
Ser Lys Ile Tyr Cys Pro Thr Ile Asp Leu Tyr Asn Trp Thr Ala Pro 
    130                 135                 140                 
Leu Glu Trp Phe Lys Asn Cys Gln Ala Leu Gln Gly Ser Arg Tyr Lys 
145                 150                 155                 160 
Ala His Lys Ser Phe Leu Val Ile Asp Asn Val Met Thr Asp Asp Ala 
                165                 170                 175     
Gly Asp Tyr Thr Cys Lys Phe Ile His Asn Glu Asn Gly Ala Asn Tyr 
            180                 185                 190         
Ser Val Thr Ala Thr Arg Ser Phe Thr Val Lys Asp Glu Gln Gly Phe 
        195                 200                 205             
Ser Arg Phe Pro Val Ile Arg Ala Pro Ala His Asn Glu Thr Lys Glu 
    210                 215                 220                 
Val Glu Ile Gly Glu Asn Thr Asn Leu Thr Cys Ser Ala Cys Phe Gly 
225                 230                 235                 240 
Lys Gly Ala Gln Phe Leu Ala Ala Val Gln Trp Gln Leu Asn Gly Asn 
                245                 250                 255     
Lys Ile Thr Asp Phe Ser Glu Pro Arg Ile Gln Gln Glu Glu Gly Gln 
            260                 265                 270         
Asn Gln Ser Phe Ser Asp Gly Leu Ala Cys Val Asn Thr Val Leu Arg 
        275                 280                 285             
Ile Ala Asp Val Lys Glu Glu Asp Leu Leu Leu Arg Tyr Asp Cys Leu 
    290                 295                 300                 
Ala Leu Asn Leu His Gly Leu Arg Arg His Thr Ile Arg Leu Ser Arg 
305                 310                 315                 320 
Lys Asn Pro Ile Asp His Gln Ser Thr Tyr Cys Ile Ile Ala Val Cys 
                325                 330                 335     
Ser Val Leu Leu Met Leu Ile Asn Val Leu Val Ile Ile Leu Lys Thr 
            340                 345                 350         
Phe Trp Ile Glu Ala Thr Leu Leu Trp Arg Asp Ile Ala Lys Pro Tyr 
        355                 360                 365             
Lys Thr Arg Asn Asp Gly Lys Leu Tyr Asp Ala Tyr Val Ile Tyr Pro 
    370                 375                 380                 
Arg Asn Tyr Thr Ser Ser Thr Asp Gly Ala Ser Arg Val Glu Tyr Phe 
385                 390                 395                 400 
Val His Gln Ile Leu Pro Asp Val Leu Glu Asn Lys Cys Gly Tyr Thr 
                405                 410                 415     
Leu Cys Ile Tyr Gly Arg Asp Met Leu Pro Gly Glu Asp Val Val Thr 
            420                 425                 430         
Ala Val Glu Thr Asn Ile Arg Lys Ser Arg Arg His Ile Phe Ile Leu 
        435                 440                 445             
Thr Pro Gln Ile Thr His Ser Glu Glu Phe Ala Tyr Glu Gln Glu Val 
    450                 455                 460                 
Ala Leu His Ser Ala Leu Ile Gln Asn Asp Ser Lys Val Ile Leu Ile 
465                 470                 475                 480 
Glu Met Glu Ala Leu Ser Glu Leu Asp Met Leu Gln Ala Glu Ala Leu 
                485                 490                 495     
Gln Asp Ser Leu Arg His Leu Met Glu Val Gln Gly Thr Ile Lys Trp 
            500                 505                 510         
Arg Glu Asp His Val Ala Asn Lys Arg Ser Leu Asn Ser Lys Phe Trp 
        515                 520                 525             
Lys His Val Arg Tyr Gln Met Pro Val Pro Ser Lys Met Pro Arg Lys 
    530                 535                 540                 
Ala Ser Ser Leu Thr Ser Leu Ala Ala Gln Lys Gln 
545                 550                 555     

<210>  11
<211>  5
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  11
Asp Tyr Glu Met His 
1               5   

<210>  12
<211>  5
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  12
Asp Ser Glu Met His 
1               5   

<210>  13
<211>  5
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  13
Asp Ser Glu Ile His 
1               5   

<210>  14
<211>  5
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  14
Asp Tyr Glu Met Gln 
1               5   

<210>  15
<211>  17
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  15
Thr Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  16
<211>  17
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  16
Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Ser Gln Asn Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  17
<211>  17
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (12)
<223>  X is N or A


<220>
<221>  UNSURE
<222>  (13)
<223>  X is Q or E or K


<220>
<221>  UNSURE
<222>  (16)
<223>  X is K or Q


<220>
<223>  抗体31C8的HV-CDR2


<400>  17
Ala Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Xaa Xaa Lys Phe Xaa 
1               5                   10                  15      
Gly 
    

<210>  18
<211>  17
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  18
Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  19
<211>  17
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  19
Ala Phe Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210>  20
<211>  12
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  20
Tyr Ser Tyr Thr Asn Ser Pro Tyr Gly Met Asp Tyr 
1               5                   10          

<210>  21
<211>  9
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  21
Ser Ala Thr Asp Tyr Tyr Phe Ala Ser 
1               5                   

<210>  22
<211>  9
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  22
Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr 
1               5                   

<210>  23
<211>  9
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  23
Ser Thr Thr Asp Cys Tyr Phe Ala Tyr 
1               5                   

<210>  24
<211>  10
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  24
Val Asp Ser Asn Tyr Asp Tyr Phe Asp Tyr 
1               5                   10  

<210>  25
<211>  11
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  25
Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      

<210>  26
<211>  16
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  26
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Thr Tyr Leu Tyr 
1               5                   10                  15      

<210>  27
<211>  16
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  27
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Ile Ile Tyr Leu Tyr 
1               5                   10                  15      

<210>  28
<211>  10
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  28
Arg Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  

<210>  29
<211>  7
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  29
Tyr Ala Ser Asn Arg Tyr Thr 
1               5           

<210>  30
<211>  7
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  UNSURE
<222>  (2)
<223>  X is M or L


<220>
<223>  抗体3C6、31C8、26A1和8F4的LV-CDR2


<400>  30
Gln Xaa Ser Asn Leu Ala Ser 
1               5           

<210>  31
<211>  7
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  31
Asp Thr Ser Asn Leu Ala Ser 
1               5           

<210>  32
<211>  9
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  32
Gln Gln Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   

<210>  33
<211>  9
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  33
Gln Gln Trp Ser Ser Asn Pro Leu Thr 
1               5                   

<210>  34
<211>  9
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  34
Ala Gln Asn Leu Glu Leu Pro Phe Thr 
1               5                   

<210>  35
<211>  121
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  35
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Thr Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Tyr Ser Tyr Thr Asn Ser Pro Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210>  36
<211>  107
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  36
Asp Val Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Asn Thr Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210>  37
<211>  118
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  37
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Asp Tyr Thr Ile Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Ser Ala Thr Asp Tyr Tyr Phe Ala Ser Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser 
        115             

<210>  38
<211>  112
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  38
Asp Ile Val Met Thr Gln Ala Ala Ile Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Met Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly His Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  39
<211>  118
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  39
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Ser 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser 
        115             

<210>  40
<211>  112
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  40
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  41
<211>  118
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  41
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Asp Ser 
            20                  25                  30          
Glu Ile His Trp Val Lys Gln Thr Leu Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Gly Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Gly Ser Thr Thr Asp Cys Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser 
        115             

<210>  42
<211>  112
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  42
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  43
<211>  118
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  43
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly His Ile Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met Gln Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Phe Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Leu Thr Val Ser Ser 
        115             

<210>  44
<211>  112
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  44
Asp Val Val Met Thr Gln Thr Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         

<210>  45
<211>  119
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  45
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val Leu Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ile Arg Val Asp Ser Asn Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Asp 
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser 
        115                 

<210>  46
<211>  106
<212>  PRT
<213>  小鼠(Mus sp.)

<400>  46
Asp Ile Val Leu Thr Gln Ser Pro Pro Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     

<210>  47
<211>  447
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体7D1的重链


<400>  47
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Asp Trp Ile 
        35                  40                  45              
Gly Thr Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Arg Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Tyr Ser Tyr Thr Asn Ser Pro Tyr Gly Met Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 
Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210>  48
<211>  1344
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体7D1的重链


<400>  48
caggtgcagc tgcagcagtc tggagctgag ctggtgaggc caggagcttc cgtgaccctg        60
agctgcaagg cctctggcta caccttcaca gactatgaga tgcactgggt gaagcagacc       120
cccgtgcatg gcctggattg gatcggcaca atcgaccctg agaccggcga tacagcttac       180
aaccagaagt ttaagggcag ggccaccctg acagctgaca agtccagctc taccgcctat       240
atggagctgt ccagcctgac aagcgaggat tccgccgtgt actattgtac ccggtactcc       300
tatacaaata gcccctacgg catggactat tggggccagg gcacctccgt gacagtgtct       360
tccgctagca caaagggccc tagcgtgttc ccactggctc cctgctccag aagcacatct       420
gagtccaccg ccgctctggg ctgtctggtg aaggactact tccctgagcc agtgacagtg       480
tcctggaaca gcggcgccct gacatccgga gtgcacacct ttccagctgt gctgcagtcc       540
agcggcctgt acagcctgtc ttccgtggtg accgtgccca gctctaattt tggcacccag       600
acatatacct gcaacgtgga ccataagcct tctaatacaa aggtggataa gaccgtggag       660
aggaagtgct gcgtggagtg cccaccttgt ccagctccac cagtggctgg cccttccgtg       720
ttcctgtttc ctccaaagcc aaaggacaca ctgatgatct ctcggacacc cgaggtgacc       780
tgcgtggtgg tggacgtgtc ccacgaggat ccagaggtgc agttcaactg gtacgtggat       840
ggcgtggagg tgcataatgc caagaccaag cccagggagg agcagttcaa ctctacattt       900
cgggtggtgt ccgtgctgac cgtggtgcac caggattggc tgaacggcaa ggagtataag       960
tgcaaggtga gcaataaggg cctgcccgct cctatcgaga agacaatctc taagaccaag      1020
ggccagccta gagagccaca ggtgtacacc ctgccccctt cccgcgagga gatgacaaag      1080
aaccaggtga gcctgacctg tctggtgaag ggcttctatc cttctgacat ctccgtggag      1140
tgggagagca atggccagcc agagaacaat tacaagacca caccacccat gctggacagc      1200
gatggctctt tctttctgta tagcaagctg acagtggata agtctcgctg gcagcagggc      1260
aacgtgttta gctgctctgt gatgcatgag gccctgcaca atcattatac ccagaagtcc      1320
ctgagcctgt ctcccggcaa gtga                                             1344

<210>  49
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体7D1的轻链


<400>  49
Asp Val Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Asn Thr Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  50
<211>  645
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体7D1的轻链


<400>  50
gacgtggtca tgacccagac acccaagttc ctgctggtga gcgccggcga cagggtgacc        60
atcacatgca aggcctctca gtccgtgagc aacgatgtgg cttggtacca gcagaagccc       120
ggccagtctc ctaagctgct gatctactat gcttccaata ggtacaccgg cgtgccagac       180
cggtttaccg gctctggcta tggcacagat ttcaccttta caatcaacac agtgcaggcc       240
gaggacctgg ccgtgtactt ctgtcagcag gattactcca gcccctatac ctttggcggc       300
ggcacaaagc tggagatcaa gcgtacggtg gccgctccca gcgtgttcat ctttccccct       360
tctgacgagc agctgaagtc tggcaccgct tccgtggtgt gcctgctgaa caatttctac       420
cccagagagg ccaaggtgca gtggaaggtg gataacgctc tgcagtccgg caatagccag       480
gagtctgtga ccgagcagga ctccaaggat agcacatatt ctctgtcttc caccctgaca       540
ctgtctaagg ccgactacga gaagcacaag gtgtatgctt gcgaggtgac ccatcagggc       600
ctgagctctc ctgtgacaaa gtcctttaat cgcggcgagt gttga                       645

<210>  51
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体3C6的重链


<400>  51
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Asp Tyr Thr Ile Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Ser Gln Asn Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Glu Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Arg Ser Ala Thr Asp Tyr Tyr Phe Ala Ser Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  52
<211>  1344
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体3C6的重链


<400>  52
caggtgcagc tgcagcagtc tggagctgag ctggtgaggc caggagcttc cgtgaccctg        60
agctgcaagg cctctggcta caccttcaca gactatgaga tgcactgggt gaagcagacc       120
cccgtgcatg gcctggattg gatcggcaca atcgaccctg agaccggcga tacagcttac       180
aaccagaagt ttaagggcag ggccaccctg acagctgaca agtccagctc taccgcctat       240
atggagctgt ccagcctgac aagcgaggat tccgccgtgt actattgtac ccggtactcc       300
tatacaaata gcccctacgg catggactat tggggccagg gcacctccgt gacagtgtct       360
tccgctagca caaagggccc tagcgtgttc ccactggctc cctgctccag aagcacatct       420
gagtccaccg ccgctctggg ctgtctggtg aaggactact tccctgagcc agtgacagtg       480
tcctggaaca gcggcgccct gacatccgga gtgcacacct ttccagctgt gctgcagtcc       540
agcggcctgt acagcctgtc ttccgtggtg accgtgccca gctctaattt tggcacccag       600
acatatacct gcaacgtgga ccataagcct tctaatacaa aggtggataa gaccgtggag       660
aggaagtgct gcgtggagtg cccaccttgt ccagctccac cagtggctgg cccttccgtg       720
ttcctgtttc ctccaaagcc aaaggacaca ctgatgatct ctcggacacc cgaggtgacc       780
tgcgtggtgg tggacgtgtc ccacgaggat ccagaggtgc agttcaactg gtacgtggat       840
ggcgtggagg tgcataatgc caagaccaag cccagggagg agcagttcaa ctctacattt       900
cgggtggtgt ccgtgctgac cgtggtgcac caggattggc tgaacggcaa ggagtataag       960
tgcaaggtga gcaataaggg cctgcccgct cctatcgaga agacaatctc taagaccaag      1020
ggccagccta gagagccaca ggtgtacacc ctgccccctt cccgcgagga gatgacaaag      1080
aaccaggtga gcctgacctg tctggtgaag ggcttctatc cttctgacat ctccgtggag      1140
tgggagagca atggccagcc agagaacaat tacaagacca caccacccat gctggacagc      1200
gatggctctt tctttctgta tagcaagctg acagtggata agtctcgctg gcagcagggc      1260
aacgtgttta gctgctctgt gatgcatgag gccctgcaca atcattatac ccagaagtcc      1320
ctgagcctgt ctcccggcaa gtga                                             1344

<210>  53
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体3C6的轻链


<400>  53
Asp Ile Val Met Thr Gln Ala Ala Ile Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Met Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly His Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  54
<211>  660
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体3C6的轻链


<400>  54
gacatcgtga tgacccaggc cgctatctct aaccccgtga ccctgggcac atctgcctcc        60
atgagctgca ggtccagcaa gtctctgctg cactccaatg gcatcacata cctgtattgg       120
tacctgcaga agcccggcca ttcccctcag ctgctgatct atcagatgag caacctggct       180
tctggcgtgc cagacaggtt ctcttccagc ggctccggca ccgacttcac cctgaagatc       240
agcagggtgg aggctgagga tgtgggcgtg tactattgtg ctcagaatct ggagctgccc       300
ttcacctttg gctccggcac aaagctggag atcaagcgta cggtggccgc tcccagcgtg       360
ttcatctttc ccccttctga cgagcagctg aagtctggca ccgcttccgt ggtgtgcctg       420
ctgaacaatt tctaccccag agaggccaag gtgcagtgga aggtggataa cgctctgcag       480
tccggcaata gccaggagtc tgtgaccgag caggactcca aggatagcac atattctctg       540
tcttccaccc tgacactgtc taaggccgac tacgagaagc acaaggtgta tgcttgcgag       600
gtgacccatc agggcctgag ctctcctgtg acaaagtcct ttaatcgcgg cgagtgttga       660

<210>  55
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体26A1的重链


<400>  55
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Asp Tyr Ile Phe Thr Asp Ser 
            20                  25                  30          
Glu Ile His Trp Val Lys Gln Thr Leu Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Gly Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Gly Ser Thr Thr Asp Cys Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  56
<211>  1335
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体26A1的重链


<400>  56
caggtgcagc tgcagcagtc tggagctgag ctggtgaggc caggagcttc tgtgaccctg        60
tcctgcaagg ccagcgacta catcttcacc gattccgaga tccactgggt gaagcagaca       120
ctggtgcatg gcctggagtg gatcggagct atcgaccctg agaccggcga tacagcttac       180
aaccagaagt ttaagggcaa ggccaccctg acagctgaca agtccagctc taccgcctat       240
atggagctgt ccagcctgac atccgagggc tccgccgtgt actattgcag cggctctacc       300
acagattgtt acttcgctta ttggggccag ggcaccacac tgacagtgtc ttccgctagc       360
acaaagggcc ctagcgtgtt cccactggct ccctgctcca gaagcacatc tgagtccacc       420
gccgctctgg gctgtctggt gaaggactac ttccctgagc cagtgacagt gtcctggaac       480
agcggcgccc tgacatccgg agtgcacacc tttccagctg tgctgcagtc cagcggcctg       540
tacagcctgt cttccgtggt gaccgtgccc agctctaatt ttggcaccca gacatatacc       600
tgcaacgtgg accataagcc ttctaataca aaggtggata agaccgtgga gaggaagtgc       660
tgcgtggagt gcccaccttg tccagctcca ccagtggctg gcccttccgt gttcctgttt       720
cctccaaagc caaaggacac actgatgatc tctcggacac ccgaggtgac ctgcgtggtg       780
gtggacgtgt cccacgagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag       840
gtgcataatg ccaagaccaa gcccagggag gagcagttca actctacatt tcgggtggtg       900
tccgtgctga ccgtggtgca ccaggattgg ctgaacggca aggagtataa gtgcaaggtg       960
agcaataagg gcctgcccgc tcctatcgag aagacaatct ctaagaccaa gggccagcct      1020
agagagccac aggtgtacac cctgccccct tcccgcgagg agatgacaaa gaaccaggtg      1080
agcctgacct gtctggtgaa gggcttctat ccttctgaca tctccgtgga gtgggagagc      1140
aatggccagc cagagaacaa ttacaagacc acaccaccca tgctggacag cgatggctct      1200
ttctttctgt atagcaagct gacagtggat aagtctcgct ggcagcaggg caacgtgttt      1260
agctgctctg tgatgcatga ggccctgcac aatcattata cccagaagtc cctgagcctg      1320
tctcccggca agtga                                                       1335

<210>  57
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体26A1的轻链


<400>  57
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  58
<211>  660
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体26A1的轻链


<400>  58
gacatcgtga tgacccaggc cgctttctct aaccccgtga ccctgggcac atctgcctcc        60
atcagctgca gatccagcaa gtctctgctg cactccaatg gcatcatcta cctgtattgg       120
tacctgcaga agcccggcca gtcccctcag ctgctgatct atcagatgag caacctggct       180
tctggcgtgc cagaccgctt ctcttccagc ggctccggca ccgacttcac cctgaggatc       240
agcagggtgg aggctgagga tgtgggcgtg tactattgtg ctcagaatct ggagctgccc       300
ttcacctttg gctccggcac aaagctggag atcaagcgta cggtggccgc tcccagcgtg       360
ttcatctttc ccccttctga cgagcagctg aagtctggca ccgcttccgt ggtgtgcctg       420
ctgaacaatt tctaccccag agaggccaag gtgcagtgga aggtggataa cgctctgcag       480
tccggcaata gccaggagtc tgtgaccgag caggactcca aggatagcac atattctctg       540
tcttccaccc tgacactgtc taaggccgac tacgagaagc acaaggtgta tgcttgcgag       600
gtgacccatc agggcctgag ctctcctgtg acaaagtcct ttaatcgcgg cgagtgttga       660

<210>  59
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体8F4的重链


<400>  59
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly His Ile Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met Gln Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Phe Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ser Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  60
<211>  1335
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体8F4的重链


<400>  60
caggtgcagc tgcagcagtc tggagctgag ctggtgaggc caggagcttc tgtgaccctg        60
tcctgcaagg ccagcggcca catcttcacc gactacgaga tgcagtgggt gaagcagaca       120
ccagtgcatg gactggagtg gatcggagcc ttcgaccctg agaccggcga tacagcttac       180
aaccagaagt ttaagggcaa ggccaccctg acagctgata agtccagctc taccgcctat       240
atggagctgt ccagcctgac atccgaggac tccgccgtgt actattgtag cggctctacc       300
acagattact attttgctta ttggggccag ggcacctccc tgacagtgtc ttccgctagc       360
acaaagggcc ctagcgtgtt cccactggct ccctgctcca gaagcacatc tgagtccacc       420
gccgctctgg gctgtctggt gaaggactac ttccctgagc cagtgacagt gtcctggaac       480
agcggcgccc tgacatccgg agtgcacacc tttccagctg tgctgcagtc cagcggcctg       540
tacagcctgt cttccgtggt gaccgtgccc agctctaatt ttggcaccca gacatatacc       600
tgcaacgtgg accataagcc ttctaataca aaggtggata agaccgtgga gaggaagtgc       660
tgcgtggagt gcccaccttg tccagctcca ccagtggctg gcccttccgt gttcctgttt       720
cctccaaagc caaaggacac actgatgatc tctcggacac ccgaggtgac ctgcgtggtg       780
gtggacgtgt cccacgagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag       840
gtgcataatg ccaagaccaa gcccagggag gagcagttca actctacatt tcgggtggtg       900
tccgtgctga ccgtggtgca ccaggattgg ctgaacggca aggagtataa gtgcaaggtg       960
agcaataagg gcctgcccgc tcctatcgag aagacaatct ctaagaccaa gggccagcct      1020
agagagccac aggtgtacac cctgccccct tcccgcgagg agatgacaaa gaaccaggtg      1080
agcctgacct gtctggtgaa gggcttctat ccttctgaca tctccgtgga gtgggagagc      1140
aatggccagc cagagaacaa ttacaagacc acaccaccca tgctggacag cgatggctct      1200
ttctttctgt atagcaagct gacagtggat aagtctcgct ggcagcaggg caacgtgttt      1260
agctgctctg tgatgcatga ggccctgcac aatcattata cccagaagtc cctgagcctg      1320
tctcccggca agtga                                                       1335

<210>  61
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体8F4的轻链


<400>  61
Asp Val Val Met Thr Gln Thr Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  62
<211>  660
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体8F4的轻链


<400>  62
gacgtggtca tgacccagac agccttctct aaccccgtga ccctgggcac atctgcttcc        60
atcagctgca gatccagcaa gtctctgctg cactccaatg gcatcatcta cctgtattgg       120
tacctgcaga agcccggcca gtcccctcag ctgctgatct atcagatgag caacctggcc       180
tctggcgtgc cagaccgctt ctcttccagc ggctccggca ccgacttcac cctgaggatc       240
agcagggtgg aggctgagga tgtgggcgtg tactattgtg ctcagaatct ggagctgccc       300
ttcacctttg gctccggcac aaagctggag atcaagcgta cggtggccgc tcccagcgtg       360
ttcatctttc ccccttctga cgagcagctg aagtctggca ccgcttccgt ggtgtgcctg       420
ctgaacaatt tctaccccag agaggccaag gtgcagtgga aggtggataa cgctctgcag       480
tccggcaata gccaggagtc tgtgaccgag caggactcca aggatagcac atattctctg       540
tcttccaccc tgacactgtc taaggccgac tacgagaagc acaaggtgta tgcttgcgag       600
gtgacccatc agggcctgag ctctcctgtg acaaagtcct ttaatcgcgg cgagtgttga       660

<210>  63
<211>  445
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体17E2的重链


<400>  63
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val Leu Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Ala Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ile Arg Val Asp Ser Asn Tyr Asp Tyr Phe Asp Tyr Trp Gly Gln Asp 
            100                 105                 110         
Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             
Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 
Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 
Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     
Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         
Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             
Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 
Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 
Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     
Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         
Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             
Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 
Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 
Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     
Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         
Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             
Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 
Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 
Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     
Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         
His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 

<210>  64
<211>  1338
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体17E2的重链


<400>  64
caggtgcagc tgcagcagtc cggagctgag ctggtgaggc caggagcttc cgtgaccctg        60
agctgcaagg cctctggcta caccttcaca gactatgaga tgcactgggt gaagcagaca       120
cccgtgctgg gactggagtg gatcggagct atcgaccctg agaccggcga tacagcttac       180
aaccagaagt ttaagggcaa ggccaccctg acagctgaca agtccagctc taccgcttat       240
atggagctgt ccagcctggc cagcgaggac tccgccgtgt actattgtat ccgggtggat       300
agcaattacg actatttcga ttactggggc caggatacca cactgacagt gtcttccgct       360
agcacaaagg gccctagcgt gttcccactg gctccctgct ccagaagcac atctgagtcc       420
accgccgctc tgggctgtct ggtgaaggac tacttccctg agccagtgac agtgtcctgg       480
aacagcggcg ccctgacatc cggagtgcac acctttccag ctgtgctgca gtccagcggc       540
ctgtacagcc tgtcttccgt ggtgaccgtg cccagctcta attttggcac ccagacatat       600
acctgcaacg tggaccataa gccttctaat acaaaggtgg ataagaccgt ggagaggaag       660
tgctgcgtgg agtgcccacc ttgtccagct ccaccagtgg ctggcccttc cgtgttcctg       720
tttcctccaa agccaaagga cacactgatg atctctcgga cacccgaggt gacctgcgtg       780
gtggtggacg tgtcccacga ggatccagag gtgcagttca actggtacgt ggatggcgtg       840
gaggtgcata atgccaagac caagcccagg gaggagcagt tcaactctac atttcgggtg       900
gtgtccgtgc tgaccgtggt gcaccaggat tggctgaacg gcaaggagta taagtgcaag       960
gtgagcaata agggcctgcc cgctcctatc gagaagacaa tctctaagac caagggccag      1020
cctagagagc cacaggtgta caccctgccc ccttcccgcg aggagatgac aaagaaccag      1080
gtgagcctga cctgtctggt gaagggcttc tatccttctg acatctccgt ggagtgggag      1140
agcaatggcc agccagagaa caattacaag accacaccac ccatgctgga cagcgatggc      1200
tctttctttc tgtatagcaa gctgacagtg gataagtctc gctggcagca gggcaacgtg      1260
tttagctgct ctgtgatgca tgaggccctg cacaatcatt atacccagaa gtccctgagc      1320
ctgtctcccg gcaagtga                                                    1338

<210>  65
<211>  213
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体17E2的轻链


<400>  65
Asp Ile Val Leu Thr Gln Ser Pro Pro Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      
Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          
His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              
Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  
Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  
Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             
Asn Arg Gly Glu Cys 
    210             

<210>  66
<211>  642
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体17E2的轻链


<400>  66
gacatcgtgc tgacccagag cccacctatc ctgagcgcct ctccaggaga gaaggtgacc        60
atgacatgca gggcttccag ctccgtgtcc tacatgcact ggtatcagca gaagcctggc       120
tccagcccaa agccctggat ctacgacacc tctaacctgg cttccggagt gccagctagg       180
ttctccggca gcggctctgg cacctcctat agcctgacaa tctccagggt ggaggctgag       240
gatgctgcta catactattg tcagcagtgg tcttccaatc ctctgacctt tggcgctggc       300
acaaagctgg agctgaagcg tacggtggcc gctcccagcg tgttcatctt tcccccttct       360
gacgagcagc tgaagtctgg caccgcttcc gtggtgtgcc tgctgaacaa tttctacccc       420
agagaggcca aggtgcagtg gaaggtggat aacgctctgc agtccggcaa tagccaggag       480
tctgtgaccg agcaggactc caaggatagc acatattctc tgtcttccac cctgacactg       540
tctaaggccg actacgagaa gcacaaggtg tatgcttgcg aggtgaccca tcagggcctg       600
agctctcctg tgacaaagtc ctttaatcgc ggcgagtgtt ga                          642

<210>  67
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体31C8的重链


<400>  67
Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Ser 
            20                  25                  30          
Glu Met His Trp Val Lys Gln Thr Pro Val His Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Ser 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  68
<211>  1335
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体31C8的重链


<400>  68
caggtgcagc tgcagcagtc tggaccagag ctggtgaggc ctggagcctc cgtgaccctg        60
agctgcaagg cttctggcta catcttcatc gactccgaga tgcactgggt gaagcagaca       120
ccagtgcatg gactggagtg gatcggagct atcgacccag agaccggcga tacagtgtat       180
aaccagaagt ttaagggcaa ggccaccctg acagctgata agtccagctc taccgcctcc       240
atggagctgt ccagcctgac aagcgaggac tccgccgtgt actattgtac cggcagcacc       300
acagattact atttcgctta ctggggccag ggcaccacac tgacagtgtc ttccgctagc       360
acaaagggcc ctagcgtgtt cccactggct ccctgctcca gaagcacatc tgagtccacc       420
gccgctctgg gctgtctggt gaaggactac ttccctgagc cagtgacagt gtcctggaac       480
agcggcgccc tgacatccgg agtgcacacc tttccagctg tgctgcagtc cagcggcctg       540
tacagcctgt cttccgtggt gaccgtgccc agctctaatt ttggcaccca gacatatacc       600
tgcaacgtgg accataagcc ttctaataca aaggtggata agaccgtgga gaggaagtgc       660
tgcgtggagt gcccaccttg tccagctcca ccagtggctg gcccttccgt gttcctgttt       720
cctccaaagc caaaggacac actgatgatc tctcggacac ccgaggtgac ctgcgtggtg       780
gtggacgtgt cccacgagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag       840
gtgcataatg ccaagaccaa gcccagggag gagcagttca actctacatt tcgggtggtg       900
tccgtgctga ccgtggtgca ccaggattgg ctgaacggca aggagtataa gtgcaaggtg       960
agcaataagg gcctgcccgc tcctatcgag aagacaatct ctaagaccaa gggccagcct      1020
agagagccac aggtgtacac cctgccccct tcccgcgagg agatgacaaa gaaccaggtg      1080
agcctgacct gtctggtgaa gggcttctat ccttctgaca tctccgtgga gtgggagagc      1140
aatggccagc cagagaacaa ttacaagacc acaccaccca tgctggacag cgatggctct      1200
ttctttctgt atagcaagct gacagtggat aagtctcgct ggcagcaggg caacgtgttt      1260
agctgctctg tgatgcatga ggccctgcac aatcattata cccagaagtc cctgagcctg      1320
tctcccggca agtga                                                       1335

<210>  69
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体31C8的轻链


<400>  69
Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 
1               5                   10                  15      
Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  70
<211>  660
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  嵌合抗体31C8的轻链


<400>  70
gacatcgtga tgacccaggc cgctttctct aaccccgtga ccctgggcac atctgcctcc        60
atcagctgca gatccagcaa gtctctgctg cactccaatg gcatcatcta cctgtattgg       120
tacctgcaga agcccggcca gtcccctcag ctgctgatct atcagatgag caacctggct       180
tctggcgtgc cagaccgctt ctcttccagc ggctccggca ccgacttcac cctgaggatc       240
agcagggtgg aggctgagga tgtgggcgtg tactattgtg ctcagaatct ggagctgccc       300
ttcacctttg gctccggcac aaagctggag atcaagcgta cggtggccgc tcccagcgtg       360
ttcatctttc ccccttctga cgagcagctg aagtctggca ccgcttccgt ggtgtgcctg       420
ctgaacaatt tctaccccag agaggccaag gtgcagtgga aggtggataa cgctctgcag       480
tccggcaata gccaggagtc tgtgaccgag caggactcca aggatagcac atattctctg       540
tcttccaccc tgacactgtc taaggccgac tacgagaagc acaaggtgta tgcttgcgag       600
gtgacccatc agggcctgag ctctcctgtg acaaagtcct ttaatcgcgg cgagtgttga       660

<210>  71
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1的HV


<400>  71
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Ser 
            20                  25                  30          
Glu Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  72
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1的HV


<400>  72
gaggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggcgctac cgtgaagatc        60
agctgcaagg cctctggcta catcttcatc gactccgaga tgcactgggt gcagcaggct       120
ccaggcaagg gactggagtg gatgggcgct atcgaccctg agaccggcga tacagtgtac       180
gctgagaagt ttcagggcag ggtgaccatc acagccgata agtccagctc tacagcttat       240
atggagctgt ccagcctgcg gtccgaggac accgccgtgt actattgtac aggcagcacc       300
acagattact atttcgctta ttggggccag ggcaccctgg tgacagtgtc ttcc             354

<210>  73
<211>  118
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.2的HV


<400>  73
Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Ser 
            20                  25                  30          
Glu Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Ala Lys Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser 
        115             

<210>  74
<211>  354
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.2的HV


<400>  74
caggtgcagc tggtgcagtc tggcgccaag gtgaagaagc caggcgctac cgtgaagatc        60
agctgcaagg cctctggcta catcttcatc gactccgaga tgcactgggt gcagcaggct       120
ccaggcaagg gactggagtg gatgggcgct atcgaccctg agaccggcga tacagtgtac       180
gctaagaagt ttaagggcag ggtgaccatc acagccgata agtccagctc tacagcttat       240
atggagctgt ccagcctgcg gtccgaggac accgccgtgt actattgtac aggcagcacc       300
acagattact atttcgctta ttggggccag ggcaccctgg tgacagtgtc ttcc             354

<210>  75
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1的重链


<400>  75
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Ser 
            20                  25                  30          
Glu Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Ala Glu Lys Phe 
    50                  55                  60                  
Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  76
<211>  1335
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1的重链


<400>  76
gaggtgcagc tggtgcagtc tggcgccgag gtgaagaagc caggcgctac cgtgaagatc        60
agctgcaagg cctctggcta catcttcatc gactccgaga tgcactgggt gcagcaggct       120
ccaggcaagg gactggagtg gatgggcgct atcgaccctg agaccggcga tacagtgtac       180
gctgagaagt ttcagggcag ggtgaccatc acagccgata agtccagctc tacagcttat       240
atggagctgt ccagcctgcg gtccgaggac accgccgtgt actattgtac aggcagcacc       300
acagattact atttcgctta ttggggccag ggcaccctgg tgacagtgtc ttccgcctcc       360
accaagggcc ctagcgtgtt cccactggct ccctgctcca gaagcacatc tgagtccacc       420
gccgctctgg gctgtctggt gaaggactac ttccctgagc cagtgacagt gtcctggaac       480
agcggcgccc tgacatccgg agtgcacacc tttccagctg tgctgcagtc cagcggcctg       540
tacagcctgt cttccgtggt gaccgtgccc agctctaatt ttggcaccca gacatatacc       600
tgcaacgtgg accataagcc ttctaataca aaggtggata agaccgtgga gaggaagtgc       660
tgcgtggagt gcccaccttg tccagctcca ccagtggctg gcccttccgt gttcctgttt       720
cctccaaagc caaaggacac actgatgatc tctcggacac ccgaggtgac ctgcgtggtg       780
gtggacgtgt cccacgagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag       840
gtgcataatg ccaagaccaa gcccagggag gagcagttca actctacatt tcgggtggtg       900
tccgtgctga ccgtggtgca ccaggattgg ctgaacggca aggagtataa gtgcaaggtg       960
agcaataagg gcctgcccgc tcctatcgag aagacaatct ctaagaccaa gggccagcct      1020
agagagccac aggtgtacac cctgccccct tcccgcgagg agatgacaaa gaaccaggtg      1080
agcctgacct gtctggtgaa gggcttctat ccttctgaca tctccgtgga gtgggagagc      1140
aatggccagc cagagaacaa ttacaagacc acaccaccca tgctggacag cgatggctct      1200
ttctttctgt atagcaagct gacagtggat aagtctcgct ggcagcaggg caacgtgttt      1260
agctgctctg tgatgcatga ggccctgcac aatcattata cccagaagtc cctgagcctg      1320
tctcccggca agtga                                                       1335

<210>  77
<211>  444
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.2的重链


<400>  77
Gln Val Gln Leu Val Gln Ser Gly Ala Lys Val Lys Lys Pro Gly Ala 
1               5                   10                  15      
Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ile Asp Ser 
            20                  25                  30          
Glu Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Val Tyr Ala Lys Lys Phe 
    50                  55                  60                  
Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Gly Ser Thr Thr Asp Tyr Tyr Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             
Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         
Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             
Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys 
    210                 215                 220                 
Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             
Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 
Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 
Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
                325                 330                 335     
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
            340                 345                 350         
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             
Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
                405                 410                 415     
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 

<210>  78
<211>  1335
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.2的重链


<400>  78
caggtgcagc tggtgcagtc tggcgccaag gtgaagaagc caggcgctac cgtgaagatc        60
agctgcaagg cctctggcta catcttcatc gactccgaga tgcactgggt gcagcaggct       120
ccaggcaagg gactggagtg gatgggcgct atcgaccctg agaccggcga tacagtgtac       180
gctaagaagt ttaagggcag ggtgaccatc acagccgata agtccagctc tacagcttat       240
atggagctgt ccagcctgcg gtccgaggac accgccgtgt actattgtac aggcagcacc       300
acagattact atttcgctta ttggggccag ggcaccctgg tgacagtgtc ttccgcctcc       360
accaagggcc ctagcgtgtt cccactggct ccctgctcca gaagcacatc tgagtccacc       420
gccgctctgg gctgtctggt gaaggactac ttccctgagc cagtgacagt gtcctggaac       480
agcggcgccc tgacatccgg agtgcacacc tttccagctg tgctgcagtc cagcggcctg       540
tacagcctgt cttccgtggt gaccgtgccc agctctaatt ttggcaccca gacatatacc       600
tgcaacgtgg accataagcc ttctaataca aaggtggata agaccgtgga gaggaagtgc       660
tgcgtggagt gcccaccttg tccagctcca ccagtggctg gcccttccgt gttcctgttt       720
cctccaaagc caaaggacac actgatgatc tctcggacac ccgaggtgac ctgcgtggtg       780
gtggacgtgt cccacgagga tccagaggtg cagttcaact ggtacgtgga tggcgtggag       840
gtgcataatg ccaagaccaa gcccagggag gagcagttca actctacatt tcgggtggtg       900
tccgtgctga ccgtggtgca ccaggattgg ctgaacggca aggagtataa gtgcaaggtg       960
agcaataagg gcctgcccgc tcctatcgag aagacaatct ctaagaccaa gggccagcct      1020
agagagccac aggtgtacac cctgccccct tcccgcgagg agatgacaaa gaaccaggtg      1080
agcctgacct gtctggtgaa gggcttctat ccttctgaca tctccgtgga gtgggagagc      1140
aatggccagc cagagaacaa ttacaagacc acaccaccca tgctggacag cgatggctct      1200
ttctttctgt atagcaagct gacagtggat aagtctcgct ggcagcaggg caacgtgttt      1260
agctgctctg tgatgcatga ggccctgcac aatcattata cccagaagtc cctgagcctg      1320
tctcccggca agtga                                                       1335

<210>  79
<211>  112
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1和31C8-1.2的LV


<400>  79
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Gln Leu Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         

<210>  80
<211>  336
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1和31C8-1.2的LV


<400>  80
gacatccaga tgacccagag cccttccagc ctgtccgcca gcgtgggcga tagggtgacc        60
atcacatgcc ggtcttccaa gtctctgctg cactccaacg gcatcatcta cctgtattgg       120
taccagcaga agcccggcaa ggcccctaag ctgctgatct atcagctgag caatctggct       180
tctggcgtgc catccaggtt cagctcttcc ggctctggca ccgactttac cctgacaatc       240
agctctctgc agccagagga tttcgccaca tactattgtg ctcagaacct ggagctgccc       300
ttcacctttg gccagggcac aaaggtggag atcaag                                 336

<210>  81
<211>  219
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1和31C8-1.2的轻链


<400>  81
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Ile Ile Tyr Leu Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
        35                  40                  45              
Pro Lys Leu Leu Ile Tyr Gln Leu Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Ser Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
65                  70                  75                  80  
Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Asn 
                85                  90                  95      
Leu Glu Leu Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 

<210>  82
<211>  660
<212>  DNA
<213>  人工序列(Artificial Sequence)

<220>
<223>  人源化抗体31C8-1.1和31C8-1.2的轻链


<400>  82
gacatccaga tgacccagag cccttccagc ctgtccgcca gcgtgggcga tagggtgacc        60
atcacatgcc ggtcttccaa gtctctgctg cactccaacg gcatcatcta cctgtattgg       120
taccagcaga agcccggcaa ggcccctaag ctgctgatct atcagctgag caatctggct       180
tctggcgtgc catccaggtt cagctcttcc ggctctggca ccgactttac cctgacaatc       240
agctctctgc agccagagga tttcgccaca tactattgtg ctcagaacct ggagctgccc       300
ttcacctttg gccagggcac aaaggtggag atcaagcgta cggtggccgc tcccagcgtg       360
ttcatctttc ccccttctga cgagcagctg aagtctggca ccgcttccgt ggtgtgcctg       420
ctgaacaatt tctaccccag agaggccaag gtgcagtgga aggtggataa cgctctgcag       480
tccggcaata gccaggagtc tgtgaccgag caggactcca aggatagcac atattctctg       540
tcttccaccc tgacactgtc taaggccgac tacgagaagc acaaggtgta tgcttgcgag       600
gtgacccatc agggcctgag ctctcctgtg acaaagtcct ttaatcgcgg cgagtgttga       660

<210>  83
<211>  447
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  RG6149的重链


<400>  83
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          
Trp Ile Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              
Gly Ile Ile Tyr Pro Gly Asn Ser Asp Thr Arg Phe Ser Pro Ser Phe 
    50                  55                  60                  
Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      
Ala Arg His Gly Thr Ser Ser Asp Tyr Tyr Gly Leu Asp Val Trp Gly 
            100                 105                 110         
Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             
Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 
Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     
Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         
Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             
Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys 
    210                 215                 220                 
Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         

<210>  84
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  RG6149的轻链


<400>  84
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Asp Asn Phe Pro Leu 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

<210>  85
<211>  449
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  GSK3772847的重链


<400>  85
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ile Tyr 
            20                  25                  30          
Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              
Ser Ser Ile Arg Gly Glu Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Pro Trp Ser Thr Glu Gly Ser Phe Phe Val Leu Asp Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         
Thr Val Thr Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val 
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys 
    210                 215                 220                 
Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Ala Ala Ala Ser 
225                 230                 235                 240 
Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     
Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Ala Glu Asp 
            260                 265                 270         
Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             
Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val 
    290                 295                 300                 
Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 
Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     
Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         
Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             
Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 
Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu 
385                 390                 395                 400 
Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     
Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         
Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             
Lys 
    

<210>  86
<211>  214
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<223>  GSK3772847的轻链


<400>  86
Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Asp Asp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              
Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Ile Thr Ala Pro Leu 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 

