                         б

<110>  ̩׻޹˾
 
<120>  һƼԼή֢ķҩ

<130>  FE00395PCT

<150>  PCT/CN2020/089631
<151>  2020-05-11

<160>  18    

<170>  PatentIn version 3.5

<210>  1
<211>  2376
<212>  DNA
<213>  ˹

<220>
<223>  źĵȻøԭ(Glu-PLGGlu-άøԭ)

<400>  1
gagcctctgg atgactatgt gaatacccag ggggcttcac tgttcagtgt cactaagaag       60

cagctgggag caggaagtat agaagaatgt gcagcaaaat gtgaggagga cgaagaattc      120

acctgcaggg cattccaata tcacagtaaa gagcaacaat gtgtgataat ggctgaaaac      180

aggaagtcct ccataatcat taggatgaga gatgtagttt tatttgaaaa gaaagtgtat      240

ctctcagagt gcaagactgg gaatggaaag aactacagag ggacgatgtc caaaacaaaa      300

aatggcatca cctgtcaaaa atggagttcc acttctcccc acagacctag attctcacct      360

gctacacacc cctcagaggg actggaggag aactactgca ggaatccaga caacgatccg      420

caggggccct ggtgctatac tactgatcca gaaaagagat atgactactg cgacattctt      480

gagtgtgaag aggaatgtat gcattgcagt ggagaaaact atgacggcaa aatttccaag      540

accatgtctg gactggaatg ccaggcctgg gactctcaga gcccacacgc tcatggatac      600

attccttcca aatttccaaa caagaacctg aagaagaatt actgtcgtaa ccccgatagg      660

gagctgcggc cttggtgttt caccaccgac cccaacaagc gctgggaact ttgtgacatc      720

ccccgctgca caacacctcc accatcttct ggtcccacct accagtgtct gaagggaaca      780

ggtgaaaact atcgcgggaa tgtggctgtt accgtgtccg ggcacacctg tcagcactgg      840

agtgcacaga cccctcacac acataacagg acaccagaaa acttcccctg caaaaatttg      900

gatgaaaact actgccgcaa tcctgacgga aaaagggccc catggtgcca tacaaccaac      960

agccaagtgc ggtgggagta ctgtaagata ccgtcctgtg actcctcccc agtatccacg     1020

gaacaattgg ctcccacagc accacctgag ctaacccctg tggtccagga ctgctaccat     1080

ggtgatggac agagctaccg aggcacatcc tccaccacca ccacaggaaa gaagtgtcag     1140

tcttggtcat ctatgacacc acaccggcac cagaagaccc cagaaaacta cccaaatgct     1200

ggcctgacaa tgaactactg caggaatcca gatgccgata aaggcccctg gtgttttacc     1260

acagacccca gcgtcaggtg ggagtactgc aacctgaaaa aatgctcagg aacagaagcg     1320

agtgttgtag cacctccgcc tgttgtcctg cttccagatg tagagactcc ttccgaagaa     1380

gactgtatgt ttgggaatgg gaaaggatac cgaggcaaga gggcgaccac tgttactggg     1440

acgccatgcc aggactgggc tgcccaggag ccccatagac acagcatttt cactccagag     1500

acaaatccac gggcgggtct ggaaaaaaat tactgccgta accctgatgg tgatgtaggt     1560

ggtccctggt gctacacgac aaatccaaga aaactttacg actactgtga tgtccctcag     1620

tgtgcggccc cttcatttga ttgtgggaag cctcaagtgg agccgaagaa atgtcctgga     1680

agggttgtag gggggtgtgt ggcccaccca cattcctggc cctggcaagt cagtcttaga     1740

acaaggtttg gaatgcactt ctgtggaggc accttgatat ccccagagtg ggtgttgact     1800

gctgcccact gcttggagaa gtccccaagg ccttcatcct acaaggtcat cctgggtgca     1860

caccaagaag tgaatctcga accgcatgtt caggaaatag aagtgtctag gctgttcttg     1920

gagcccacac gaaaagatat tgccttgcta aagctaagca gtcctgccgt catcactgac     1980

aaagtaatcc cagcttgtct gccatcccca aattatgtgg tcgctgaccg gaccgaatgt     2040

ttcatcactg gctggggaga aacccaaggt acttttggag ctggccttct caaggaagcc     2100

cagctccctg tgattgagaa taaagtgtgc aatcgctatg agtttctgaa tggaagagtc     2160

caatccaccg aactctgtgc tgggcatttg gccggaggca ctgacagttg ccagggtgac     2220

agtggaggtc ctctggtttg cttcgagaag gacaaataca ttttacaagg agtcacttct     2280

tggggtcttg gctgtgcacg ccccaataag cctggtgtct atgttcgtgt ttcaaggttt     2340

gttacttgga ttgagggagt gatgagaaat aattaa                               2376


<210>  2
<211>  791
<212>  PRT
<213>  ˹

<220>
<223>  źĵȻøԭ(Glu-PLGGlu-άøԭ)

<400>  2

Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser Leu Phe Ser 
1               5                   10                  15      


Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu Cys Ala Ala 
            20                  25                  30          


Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe Gln Tyr His 
        35                  40                  45              


Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg Lys Ser Ser 
    50                  55                  60                  


Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg Gly Thr Met 
                85                  90                  95      


Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser Ser Thr Ser 
            100                 105                 110         


Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser Glu Gly Leu 
        115                 120                 125             


Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln Gly Pro Trp 
    130                 135                 140                 


Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys Asp Ile Leu 
145                 150                 155                 160 


Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn Tyr Asp Gly 
                165                 170                 175     


Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala Trp Asp Ser 
            180                 185                 190         


Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe Pro Asn Lys 
        195                 200                 205             


Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu Leu Arg Pro 
    210                 215                 220                 


Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu Cys Asp Ile 
225                 230                 235                 240 


Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr Tyr Gln Cys 
                245                 250                 255     


Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala Val Thr Val 
            260                 265                 270         


Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro His Thr His 
        275                 280                 285             


Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp Glu Asn Tyr 
    290                 295                 300                 


Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His Thr Thr Asn 
305                 310                 315                 320 


Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys Asp Ser Ser 
                325                 330                 335     


Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro Glu Leu Thr 
            340                 345                 350         


Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser Tyr Arg Gly 
        355                 360                 365             


Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser Trp Ser Ser 
    370                 375                 380                 


Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr Pro Asn Ala 
385                 390                 395                 400 


Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp Lys Gly Pro 
                405                 410                 415     


Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr Cys Asn Leu 
            420                 425                 430         


Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro Pro Pro Val 
        435                 440                 445             


Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp Cys Met Phe 
    450                 455                 460                 


Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr Val Thr Gly 
465                 470                 475                 480 


Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg His Ser Ile 
                485                 490                 495     


Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys Asn Tyr Cys 
            500                 505                 510         


Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr Thr Thr Asn 
        515                 520                 525             


Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys Ala Ala Pro 
    530                 535                 540                 


Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys Pro Gly 
545                 550                 555                 560 


Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro Trp Gln 
                565                 570                 575     


Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly Thr Leu 
            580                 585                 590         


Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu Lys Ser 
        595                 600                 605             


Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln Glu Val 
    610                 615                 620                 


Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu Phe Leu 
625                 630                 635                 640 


Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala 
                645                 650                 655     


Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr 
            660                 665                 670         


Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly Glu Thr 
        675                 680                 685             


Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu Pro Val 
    690                 695                 700                 


Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly Arg Val 
705                 710                 715                 720 


Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr Asp Ser 
                725                 730                 735     


Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys 
            740                 745                 750         


Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro 
        755                 760                 765             


Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr Trp Ile 
    770                 775                 780                 


Glu Gly Val Met Arg Asn Asn 
785                 790     


<210>  3
<211>  2433
<212>  DNA
<213>  ˹

<220>
<223>  źĵȻøԭ(Դswiss prot)ĺ

<400>  3
atggaacata aggaagtggt tcttctactt cttttatttc tgaaatcagg tcaaggagag       60

cctctggatg actatgtgaa tacccagggg gcttcactgt tcagtgtcac taagaagcag      120

ctgggagcag gaagtataga agaatgtgca gcaaaatgtg aggaggacga agaattcacc      180

tgcagggcat tccaatatca cagtaaagag caacaatgtg tgataatggc tgaaaacagg      240

aagtcctcca taatcattag gatgagagat gtagttttat ttgaaaagaa agtgtatctc      300

tcagagtgca agactgggaa tggaaagaac tacagaggga cgatgtccaa aacaaaaaat      360

ggcatcacct gtcaaaaatg gagttccact tctccccaca gacctagatt ctcacctgct      420

acacacccct cagagggact ggaggagaac tactgcagga atccagacaa cgatccgcag      480

gggccctggt gctatactac tgatccagaa aagagatatg actactgcga cattcttgag      540

tgtgaagagg aatgtatgca ttgcagtgga gaaaactatg acggcaaaat ttccaagacc      600

atgtctggac tggaatgcca ggcctgggac tctcagagcc cacacgctca tggatacatt      660

ccttccaaat ttccaaacaa gaacctgaag aagaattact gtcgtaaccc cgatagggag      720

ctgcggcctt ggtgtttcac caccgacccc aacaagcgct gggaactttg tgacatcccc      780

cgctgcacaa cacctccacc atcttctggt cccacctacc agtgtctgaa gggaacaggt      840

gaaaactatc gcgggaatgt ggctgttacc gtgtccgggc acacctgtca gcactggagt      900

gcacagaccc ctcacacaca taacaggaca ccagaaaact tcccctgcaa aaatttggat      960

gaaaactact gccgcaatcc tgacggaaaa agggccccat ggtgccatac aaccaacagc     1020

caagtgcggt gggagtactg taagataccg tcctgtgact cctccccagt atccacggaa     1080

caattggctc ccacagcacc acctgagcta acccctgtgg tccaggactg ctaccatggt     1140

gatggacaga gctaccgagg cacatcctcc accaccacca caggaaagaa gtgtcagtct     1200

tggtcatcta tgacaccaca ccggcaccag aagaccccag aaaactaccc aaatgctggc     1260

ctgacaatga actactgcag gaatccagat gccgataaag gcccctggtg ttttaccaca     1320

gaccccagcg tcaggtggga gtactgcaac ctgaaaaaat gctcaggaac agaagcgagt     1380

gttgtagcac ctccgcctgt tgtcctgctt ccagatgtag agactccttc cgaagaagac     1440

tgtatgtttg ggaatgggaa aggataccga ggcaagaggg cgaccactgt tactgggacg     1500

ccatgccagg actgggctgc ccaggagccc catagacaca gcattttcac tccagagaca     1560

aatccacggg cgggtctgga aaaaaattac tgccgtaacc ctgatggtga tgtaggtggt     1620

ccctggtgct acacgacaaa tccaagaaaa ctttacgact actgtgatgt ccctcagtgt     1680

gcggcccctt catttgattg tgggaagcct caagtggagc cgaagaaatg tcctggaagg     1740

gttgtagggg ggtgtgtggc ccacccacat tcctggccct ggcaagtcag tcttagaaca     1800

aggtttggaa tgcacttctg tggaggcacc ttgatatccc cagagtgggt gttgactgct     1860

gcccactgct tggagaagtc cccaaggcct tcatcctaca aggtcatcct gggtgcacac     1920

caagaagtga atctcgaacc gcatgttcag gaaatagaag tgtctaggct gttcttggag     1980

cccacacgaa aagatattgc cttgctaaag ctaagcagtc ctgccgtcat cactgacaaa     2040

gtaatcccag cttgtctgcc atccccaaat tatgtggtcg ctgaccggac cgaatgtttc     2100

atcactggct ggggagaaac ccaaggtact tttggagctg gccttctcaa ggaagcccag     2160

ctccctgtga ttgagaataa agtgtgcaat cgctatgagt ttctgaatgg aagagtccaa     2220

tccaccgaac tctgtgctgg gcatttggcc ggaggcactg acagttgcca gggtgacagt     2280

ggaggtcctc tggtttgctt cgagaaggac aaatacattt tacaaggagt cacttcttgg     2340

ggtcttggct gtgcacgccc caataagcct ggtgtctatg ttcgtgtttc aaggtttgtt     2400

acttggattg agggagtgat gagaaataat taa                                  2433


<210>  4
<211>  810
<212>  PRT
<213>  ˹

<220>
<223>  źĵȻøԭ(Դswiss prot)İ

<400>  4

Met Glu His Lys Glu Val Val Leu Leu Leu Leu Leu Phe Leu Lys Ser 
1               5                   10                  15      


Gly Gln Gly Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser 
            20                  25                  30          


Leu Phe Ser Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu 
        35                  40                  45              


Cys Ala Ala Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe 
    50                  55                  60                  


Gln Tyr His Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg 
65                  70                  75                  80  


Lys Ser Ser Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys 
                85                  90                  95      


Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
            100                 105                 110         


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
        115                 120                 125             


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
    130                 135                 140                 


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
145                 150                 155                 160 


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
                165                 170                 175     


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
            180                 185                 190         


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
        195                 200                 205             


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
    210                 215                 220                 


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
225                 230                 235                 240 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
                245                 250                 255     


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
            260                 265                 270         


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
        275                 280                 285             


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
    290                 295                 300                 


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
305                 310                 315                 320 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
                325                 330                 335     


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
            340                 345                 350         


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
        355                 360                 365             


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
    370                 375                 380                 


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
385                 390                 395                 400 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
                405                 410                 415     


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
            420                 425                 430         


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
        435                 440                 445             


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
    450                 455                 460                 


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
465                 470                 475                 480 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
                485                 490                 495     


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
            500                 505                 510         


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
        515                 520                 525             


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
    530                 535                 540                 


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
545                 550                 555                 560 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
                565                 570                 575     


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
            580                 585                 590         


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
        595                 600                 605             


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
    610                 615                 620                 


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
625                 630                 635                 640 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
                645                 650                 655     


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
            660                 665                 670         


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
        675                 680                 685             


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
    690                 695                 700                 


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
705                 710                 715                 720 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
                725                 730                 735     


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
            740                 745                 750         


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
        755                 760                 765             


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
    770                 775                 780                 


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
785                 790                 795                 800 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                805                 810 


<210>  5
<211>  2145
<212>  DNA
<213>  ˹

<220>
<223>  LYS77-PLG(Lys-øԭ)

<400>  5
aaagtgtatc tctcagagtg caagactggg aatggaaaga actacagagg gacgatgtcc       60

aaaacaaaaa atggcatcac ctgtcaaaaa tggagttcca cttctcccca cagacctaga      120

ttctcacctg ctacacaccc ctcagaggga ctggaggaga actactgcag gaatccagac      180

aacgatccgc aggggccctg gtgctatact actgatccag aaaagagata tgactactgc      240

gacattcttg agtgtgaaga ggaatgtatg cattgcagtg gagaaaacta tgacggcaaa      300

atttccaaga ccatgtctgg actggaatgc caggcctggg actctcagag cccacacgct      360

catggataca ttccttccaa atttccaaac aagaacctga agaagaatta ctgtcgtaac      420

cccgataggg agctgcggcc ttggtgtttc accaccgacc ccaacaagcg ctgggaactt      480

tgtgacatcc cccgctgcac aacacctcca ccatcttctg gtcccaccta ccagtgtctg      540

aagggaacag gtgaaaacta tcgcgggaat gtggctgtta ccgtgtccgg gcacacctgt      600

cagcactgga gtgcacagac ccctcacaca cataacagga caccagaaaa cttcccctgc      660

aaaaatttgg atgaaaacta ctgccgcaat cctgacggaa aaagggcccc atggtgccat      720

acaaccaaca gccaagtgcg gtgggagtac tgtaagatac cgtcctgtga ctcctcccca      780

gtatccacgg aacaattggc tcccacagca ccacctgagc taacccctgt ggtccaggac      840

tgctaccatg gtgatggaca gagctaccga ggcacatcct ccaccaccac cacaggaaag      900

aagtgtcagt cttggtcatc tatgacacca caccggcacc agaagacccc agaaaactac      960

ccaaatgctg gcctgacaat gaactactgc aggaatccag atgccgataa aggcccctgg     1020

tgttttacca cagaccccag cgtcaggtgg gagtactgca acctgaaaaa atgctcagga     1080

acagaagcga gtgttgtagc acctccgcct gttgtcctgc ttccagatgt agagactcct     1140

tccgaagaag actgtatgtt tgggaatggg aaaggatacc gaggcaagag ggcgaccact     1200

gttactggga cgccatgcca ggactgggct gcccaggagc cccatagaca cagcattttc     1260

actccagaga caaatccacg ggcgggtctg gaaaaaaatt actgccgtaa ccctgatggt     1320

gatgtaggtg gtccctggtg ctacacgaca aatccaagaa aactttacga ctactgtgat     1380

gtccctcagt gtgcggcccc ttcatttgat tgtgggaagc ctcaagtgga gccgaagaaa     1440

tgtcctggaa gggttgtagg ggggtgtgtg gcccacccac attcctggcc ctggcaagtc     1500

agtcttagaa caaggtttgg aatgcacttc tgtggaggca ccttgatatc cccagagtgg     1560

gtgttgactg ctgcccactg cttggagaag tccccaaggc cttcatccta caaggtcatc     1620

ctgggtgcac accaagaagt gaatctcgaa ccgcatgttc aggaaataga agtgtctagg     1680

ctgttcttgg agcccacacg aaaagatatt gccttgctaa agctaagcag tcctgccgtc     1740

atcactgaca aagtaatccc agcttgtctg ccatccccaa attatgtggt cgctgaccgg     1800

accgaatgtt tcatcactgg ctggggagaa acccaaggta cttttggagc tggccttctc     1860

aaggaagccc agctccctgt gattgagaat aaagtgtgca atcgctatga gtttctgaat     1920

ggaagagtcc aatccaccga actctgtgct gggcatttgg ccggaggcac tgacagttgc     1980

cagggtgaca gtggaggtcc tctggtttgc ttcgagaagg acaaatacat tttacaagga     2040

gtcacttctt ggggtcttgg ctgtgcacgc cccaataagc ctggtgtcta tgttcgtgtt     2100

tcaaggtttg ttacttggat tgagggagtg atgagaaata attaa                     2145


<210>  6
<211>  714
<212>  PRT
<213>  ˹

<220>
<223>  LYS77-PLG(Lys-øԭ)

<400>  6

Lys Val Tyr Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg 
1               5                   10                  15      


Gly Thr Met Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser 
            20                  25                  30          


Ser Thr Ser Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser 
        35                  40                  45              


Glu Gly Leu Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln 
    50                  55                  60                  


Gly Pro Trp Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys 
65                  70                  75                  80  


Asp Ile Leu Glu Cys Glu Glu Glu Cys Met His Cys Ser Gly Glu Asn 
                85                  90                  95      


Tyr Asp Gly Lys Ile Ser Lys Thr Met Ser Gly Leu Glu Cys Gln Ala 
            100                 105                 110         


Trp Asp Ser Gln Ser Pro His Ala His Gly Tyr Ile Pro Ser Lys Phe 
        115                 120                 125             


Pro Asn Lys Asn Leu Lys Lys Asn Tyr Cys Arg Asn Pro Asp Arg Glu 
    130                 135                 140                 


Leu Arg Pro Trp Cys Phe Thr Thr Asp Pro Asn Lys Arg Trp Glu Leu 
145                 150                 155                 160 


Cys Asp Ile Pro Arg Cys Thr Thr Pro Pro Pro Ser Ser Gly Pro Thr 
                165                 170                 175     


Tyr Gln Cys Leu Lys Gly Thr Gly Glu Asn Tyr Arg Gly Asn Val Ala 
            180                 185                 190         


Val Thr Val Ser Gly His Thr Cys Gln His Trp Ser Ala Gln Thr Pro 
        195                 200                 205             


His Thr His Asn Arg Thr Pro Glu Asn Phe Pro Cys Lys Asn Leu Asp 
    210                 215                 220                 


Glu Asn Tyr Cys Arg Asn Pro Asp Gly Lys Arg Ala Pro Trp Cys His 
225                 230                 235                 240 


Thr Thr Asn Ser Gln Val Arg Trp Glu Tyr Cys Lys Ile Pro Ser Cys 
                245                 250                 255     


Asp Ser Ser Pro Val Ser Thr Glu Gln Leu Ala Pro Thr Ala Pro Pro 
            260                 265                 270         


Glu Leu Thr Pro Val Val Gln Asp Cys Tyr His Gly Asp Gly Gln Ser 
        275                 280                 285             


Tyr Arg Gly Thr Ser Ser Thr Thr Thr Thr Gly Lys Lys Cys Gln Ser 
    290                 295                 300                 


Trp Ser Ser Met Thr Pro His Arg His Gln Lys Thr Pro Glu Asn Tyr 
305                 310                 315                 320 


Pro Asn Ala Gly Leu Thr Met Asn Tyr Cys Arg Asn Pro Asp Ala Asp 
                325                 330                 335     


Lys Gly Pro Trp Cys Phe Thr Thr Asp Pro Ser Val Arg Trp Glu Tyr 
            340                 345                 350         


Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala Ser Val Val Ala Pro 
        355                 360                 365             


Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr Pro Ser Glu Glu Asp 
    370                 375                 380                 


Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly Lys Arg Ala Thr Thr 
385                 390                 395                 400 


Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala Gln Glu Pro His Arg 
                405                 410                 415     


His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg Ala Gly Leu Glu Lys 
            420                 425                 430         


Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly Gly Pro Trp Cys Tyr 
        435                 440                 445             


Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys Asp Val Pro Gln Cys 
    450                 455                 460                 


Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys 
465                 470                 475                 480 


Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp 
                485                 490                 495     


Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly 
            500                 505                 510         


Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu 
        515                 520                 525             


Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His 
    530                 535                 540                 


Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg 
545                 550                 555                 560 


Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser 
                565                 570                 575     


Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser 
            580                 585                 590         


Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp 
        595                 600                 605             


Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln 
    610                 615                 620                 


Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn 
625                 630                 635                 640 


Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly 
                645                 650                 655     


Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu 
            660                 665                 670         


Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys 
        675                 680                 685             


Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val 
    690                 695                 700                 


Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
705                 710                 


<210>  7
<211>  1245
<212>  DNA
<213>  ˹

<220>
<223>  delta-plg(delta-øԭ)

<400>  7
gagcctctgg atgactatgt gaatacccag ggggcttcac tgttcagtgt cactaagaag       60

cagctgggag caggaagtat agaagaatgt gcagcaaaat gtgaggagga cgaagaattc      120

acctgcaggg cattccaata tcacagtaaa gagcaacaat gtgtgataat ggctgaaaac      180

aggaagtcct ccataatcat taggatgaga gatgtagttt tatttgaaaa gaaagtgtat      240

ctctcagagt gcaagactgg gaatggaaag aactacagag ggacgatgtc caaaacaaaa      300

aatggcatca cctgtcaaaa atggagttcc acttctcccc acagacctag attctcacct      360

gctacacacc cctcagaggg actggaggag aactactgca ggaatccaga caacgatccg      420

caggggccct ggtgctatac tactgatcca gaaaagagat atgactactg cgacattctt      480

gagtgtgaag aggcggcccc ttcatttgat tgtgggaagc ctcaagtgga gccgaagaaa      540

tgtcctggaa gggttgtagg ggggtgtgtg gcccacccac attcctggcc ctggcaagtc      600

agtcttagaa caaggtttgg aatgcacttc tgtggaggca ccttgatatc cccagagtgg      660

gtgttgactg ctgcccactg cttggagaag tccccaaggc cttcatccta caaggtcatc      720

ctgggtgcac accaagaagt gaatctcgaa ccgcatgttc aggaaataga agtgtctagg      780

ctgttcttgg agcccacacg aaaagatatt gccttgctaa agctaagcag tcctgccgtc      840

atcactgaca aagtaatccc agcttgtctg ccatccccaa attatgtggt cgctgaccgg      900

accgaatgtt tcatcactgg ctggggagaa acccaaggta cttttggagc tggccttctc      960

aaggaagccc agctccctgt gattgagaat aaagtgtgca atcgctatga gtttctgaat     1020

ggaagagtcc aatccaccga actctgtgct gggcatttgg ccggaggcac tgacagttgc     1080

cagggtgaca gtggaggtcc tctggtttgc ttcgagaagg acaaatacat tttacaagga     1140

gtcacttctt ggggtcttgg ctgtgcacgc cccaataagc ctggtgtcta tgttcgtgtt     1200

tcaaggtttg ttacttggat tgagggagtg atgagaaata attaa                     1245


<210>  8
<211>  414
<212>  PRT
<213>  ˹

<220>
<223>  delta-plg(delta-øԭ)

<400>  8

Glu Pro Leu Asp Asp Tyr Val Asn Thr Gln Gly Ala Ser Leu Phe Ser 
1               5                   10                  15      


Val Thr Lys Lys Gln Leu Gly Ala Gly Ser Ile Glu Glu Cys Ala Ala 
            20                  25                  30          


Lys Cys Glu Glu Asp Glu Glu Phe Thr Cys Arg Ala Phe Gln Tyr His 
        35                  40                  45              


Ser Lys Glu Gln Gln Cys Val Ile Met Ala Glu Asn Arg Lys Ser Ser 
    50                  55                  60                  


Ile Ile Ile Arg Met Arg Asp Val Val Leu Phe Glu Lys Lys Val Tyr 
65                  70                  75                  80  


Leu Ser Glu Cys Lys Thr Gly Asn Gly Lys Asn Tyr Arg Gly Thr Met 
                85                  90                  95      


Ser Lys Thr Lys Asn Gly Ile Thr Cys Gln Lys Trp Ser Ser Thr Ser 
            100                 105                 110         


Pro His Arg Pro Arg Phe Ser Pro Ala Thr His Pro Ser Glu Gly Leu 
        115                 120                 125             


Glu Glu Asn Tyr Cys Arg Asn Pro Asp Asn Asp Pro Gln Gly Pro Trp 
    130                 135                 140                 


Cys Tyr Thr Thr Asp Pro Glu Lys Arg Tyr Asp Tyr Cys Asp Ile Leu 
145                 150                 155                 160 


Glu Cys Glu Glu Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val 
                165                 170                 175     


Glu Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala His 
            180                 185                 190         


Pro His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met 
        195                 200                 205             


His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala 
    210                 215                 220                 


Ala His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile 
225                 230                 235                 240 


Leu Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu Ile 
                245                 250                 255     


Glu Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu 
            260                 265                 270         


Leu Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala 
        275                 280                 285             


Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe 
    290                 295                 300                 


Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu 
305                 310                 315                 320 


Lys Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr 
                325                 330                 335     


Glu Phe Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His 
            340                 345                 350         


Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu 
        355                 360                 365             


Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp 
    370                 375                 380                 


Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val 
385                 390                 395                 400 


Ser Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
                405                 410                 


<210>  9
<211>  1104
<212>  DNA
<213>  ˹

<220>
<223>  Mini-plg(Сάøԭ)

<400>  9
gtcaggtggg agtactgcaa cctgaaaaaa tgctcaggaa cagaagcgag tgttgtagca       60

cctccgcctg ttgtcctgct tccagatgta gagactcctt ccgaagaaga ctgtatgttt      120

gggaatggga aaggataccg aggcaagagg gcgaccactg ttactgggac gccatgccag      180

gactgggctg cccaggagcc ccatagacac agcattttca ctccagagac aaatccacgg      240

gcgggtctgg aaaaaaatta ctgccgtaac cctgatggtg atgtaggtgg tccctggtgc      300

tacacgacaa atccaagaaa actttacgac tactgtgatg tccctcagtg tgcggcccct      360

tcatttgatt gtgggaagcc tcaagtggag ccgaagaaat gtcctggaag ggttgtaggg      420

gggtgtgtgg cccacccaca ttcctggccc tggcaagtca gtcttagaac aaggtttgga      480

atgcacttct gtggaggcac cttgatatcc ccagagtggg tgttgactgc tgcccactgc      540

ttggagaagt ccccaaggcc ttcatcctac aaggtcatcc tgggtgcaca ccaagaagtg      600

aatctcgaac cgcatgttca ggaaatagaa gtgtctaggc tgttcttgga gcccacacga      660

aaagatattg ccttgctaaa gctaagcagt cctgccgtca tcactgacaa agtaatccca      720

gcttgtctgc catccccaaa ttatgtggtc gctgaccgga ccgaatgttt catcactggc      780

tggggagaaa cccaaggtac ttttggagct ggccttctca aggaagccca gctccctgtg      840

attgagaata aagtgtgcaa tcgctatgag tttctgaatg gaagagtcca atccaccgaa      900

ctctgtgctg ggcatttggc cggaggcact gacagttgcc agggtgacag tggaggtcct      960

ctggtttgct tcgagaagga caaatacatt ttacaaggag tcacttcttg gggtcttggc     1020

tgtgcacgcc ccaataagcc tggtgtctat gttcgtgttt caaggtttgt tacttggatt     1080

gagggagtga tgagaaataa ttaa                                            1104


<210>  10
<211>  367
<212>  PRT
<213>  ˹

<220>
<223>   Mini-plg(Сάøԭ)

<400>  10

Val Arg Trp Glu Tyr Cys Asn Leu Lys Lys Cys Ser Gly Thr Glu Ala 
1               5                   10                  15      


Ser Val Val Ala Pro Pro Pro Val Val Leu Leu Pro Asp Val Glu Thr 
            20                  25                  30          


Pro Ser Glu Glu Asp Cys Met Phe Gly Asn Gly Lys Gly Tyr Arg Gly 
        35                  40                  45              


Lys Arg Ala Thr Thr Val Thr Gly Thr Pro Cys Gln Asp Trp Ala Ala 
    50                  55                  60                  


Gln Glu Pro His Arg His Ser Ile Phe Thr Pro Glu Thr Asn Pro Arg 
65                  70                  75                  80  


Ala Gly Leu Glu Lys Asn Tyr Cys Arg Asn Pro Asp Gly Asp Val Gly 
                85                  90                  95      


Gly Pro Trp Cys Tyr Thr Thr Asn Pro Arg Lys Leu Tyr Asp Tyr Cys 
            100                 105                 110         


Asp Val Pro Gln Cys Ala Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln 
        115                 120                 125             


Val Glu Pro Lys Lys Cys Pro Gly Arg Val Val Gly Gly Cys Val Ala 
    130                 135                 140                 


His Pro His Ser Trp Pro Trp Gln Val Ser Leu Arg Thr Arg Phe Gly 
145                 150                 155                 160 


Met His Phe Cys Gly Gly Thr Leu Ile Ser Pro Glu Trp Val Leu Thr 
                165                 170                 175     


Ala Ala His Cys Leu Glu Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val 
            180                 185                 190         


Ile Leu Gly Ala His Gln Glu Val Asn Leu Glu Pro His Val Gln Glu 
        195                 200                 205             


Ile Glu Val Ser Arg Leu Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala 
    210                 215                 220                 


Leu Leu Lys Leu Ser Ser Pro Ala Val Ile Thr Asp Lys Val Ile Pro 
225                 230                 235                 240 


Ala Cys Leu Pro Ser Pro Asn Tyr Val Val Ala Asp Arg Thr Glu Cys 
                245                 250                 255     


Phe Ile Thr Gly Trp Gly Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu 
            260                 265                 270         


Leu Lys Glu Ala Gln Leu Pro Val Ile Glu Asn Lys Val Cys Asn Arg 
        275                 280                 285             


Tyr Glu Phe Leu Asn Gly Arg Val Gln Ser Thr Glu Leu Cys Ala Gly 
    290                 295                 300                 


His Leu Ala Gly Gly Thr Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro 
305                 310                 315                 320 


Leu Val Cys Phe Glu Lys Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser 
                325                 330                 335     


Trp Gly Leu Gly Cys Ala Arg Pro Asn Lys Pro Gly Val Tyr Val Arg 
            340                 345                 350         


Val Ser Arg Phe Val Thr Trp Ile Glu Gly Val Met Arg Asn Asn 
        355                 360                 365         


<210>  11
<211>  750
<212>  DNA
<213>  ˹

<220>
<223>  Micro-plg(΢άøԭ)

<400>  11
gccccttcat ttgattgtgg gaagcctcaa gtggagccga agaaatgtcc tggaagggtt       60

gtaggggggt gtgtggccca cccacattcc tggccctggc aagtcagtct tagaacaagg      120

tttggaatgc acttctgtgg aggcaccttg atatccccag agtgggtgtt gactgctgcc      180

cactgcttgg agaagtcccc aaggccttca tcctacaagg tcatcctggg tgcacaccaa      240

gaagtgaatc tcgaaccgca tgttcaggaa atagaagtgt ctaggctgtt cttggagccc      300

acacgaaaag atattgcctt gctaaagcta agcagtcctg ccgtcatcac tgacaaagta      360

atcccagctt gtctgccatc cccaaattat gtggtcgctg accggaccga atgtttcatc      420

actggctggg gagaaaccca aggtactttt ggagctggcc ttctcaagga agcccagctc      480

cctgtgattg agaataaagt gtgcaatcgc tatgagtttc tgaatggaag agtccaatcc      540

accgaactct gtgctgggca tttggccgga ggcactgaca gttgccaggg tgacagtgga      600

ggtcctctgg tttgcttcga gaaggacaaa tacattttac aaggagtcac ttcttggggt      660

cttggctgtg cacgccccaa taagcctggt gtctatgttc gtgtttcaag gtttgttact      720

tggattgagg gagtgatgag aaataattaa                                       750


<210>  12
<211>  249
<212>  PRT
<213>  ˹

<220>
<223>  Micro-plg(΢άøԭ)

<400>  12

Ala Pro Ser Phe Asp Cys Gly Lys Pro Gln Val Glu Pro Lys Lys Cys 
1               5                   10                  15      


Pro Gly Arg Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro 
            20                  25                  30          


Trp Gln Val Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly 
        35                  40                  45              


Thr Leu Ile Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu 
    50                  55                  60                  


Lys Ser Pro Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln 
65                  70                  75                  80  


Glu Val Asn Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu 
                85                  90                  95      


Phe Leu Glu Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser 
            100                 105                 110         


Pro Ala Val Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro 
        115                 120                 125             


Asn Tyr Val Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly 
    130                 135                 140                 


Glu Thr Gln Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu 
145                 150                 155                 160 


Pro Val Ile Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly 
                165                 170                 175     


Arg Val Gln Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr 
            180                 185                 190         


Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys 
        195                 200                 205             


Asp Lys Tyr Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala 
    210                 215                 220                 


Arg Pro Asn Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr 
225                 230                 235                 240 


Trp Ile Glu Gly Val Met Arg Asn Asn 
                245                 


<210>  13
<211>  684
<212>  DNA
<213>  ˹

<220>
<223>   ˿ᵰø(ṹ)ĺ

<400>  13
gttgtagggg ggtgtgtggc ccacccacat tcctggccct ggcaagtcag tcttagaaca       60

aggtttggaa tgcacttctg tggaggcacc ttgatatccc cagagtgggt gttgactgct      120

gcccactgct tggagaagtc cccaaggcct tcatcctaca aggtcatcct gggtgcacac      180

caagaagtga atctcgaacc gcatgttcag gaaatagaag tgtctaggct gttcttggag      240

cccacacgaa aagatattgc cttgctaaag ctaagcagtc ctgccgtcat cactgacaaa      300

gtaatcccag cttgtctgcc atccccaaat tatgtggtcg ctgaccggac cgaatgtttc      360

atcactggct ggggagaaac ccaaggtact tttggagctg gccttctcaa ggaagcccag      420

ctccctgtga ttgagaataa agtgtgcaat cgctatgagt ttctgaatgg aagagtccaa      480

tccaccgaac tctgtgctgg gcatttggcc ggaggcactg acagttgcca gggtgacagt      540

ggaggtcctc tggtttgctt cgagaaggac aaatacattt tacaaggagt cacttcttgg      600

ggtcttggct gtgcacgccc caataagcct ggtgtctatg ttcgtgtttc aaggtttgtt      660

acttggattg agggagtgat gaga                                             684


<210>  14
<211>  228
<212>  PRT
<213>  ˹

<220>
<223>  ˿ᵰø(ṹ)İ

<400>  14

Val Val Gly Gly Cys Val Ala His Pro His Ser Trp Pro Trp Gln Val 
1               5                   10                  15      


Ser Leu Arg Thr Arg Phe Gly Met His Phe Cys Gly Gly Thr Leu Ile 
            20                  25                  30          


Ser Pro Glu Trp Val Leu Thr Ala Ala His Cys Leu Glu Lys Ser Pro 
        35                  40                  45              


Arg Pro Ser Ser Tyr Lys Val Ile Leu Gly Ala His Gln Glu Val Asn 
    50                  55                  60                  


Leu Glu Pro His Val Gln Glu Ile Glu Val Ser Arg Leu Phe Leu Glu 
65                  70                  75                  80  


Pro Thr Arg Lys Asp Ile Ala Leu Leu Lys Leu Ser Ser Pro Ala Val 
                85                  90                  95      


Ile Thr Asp Lys Val Ile Pro Ala Cys Leu Pro Ser Pro Asn Tyr Val 
            100                 105                 110         


Val Ala Asp Arg Thr Glu Cys Phe Ile Thr Gly Trp Gly Glu Thr Gln 
        115                 120                 125             


Gly Thr Phe Gly Ala Gly Leu Leu Lys Glu Ala Gln Leu Pro Val Ile 
    130                 135                 140                 


Glu Asn Lys Val Cys Asn Arg Tyr Glu Phe Leu Asn Gly Arg Val Gln 
145                 150                 155                 160 


Ser Thr Glu Leu Cys Ala Gly His Leu Ala Gly Gly Thr Asp Ser Cys 
                165                 170                 175     


Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Phe Glu Lys Asp Lys Tyr 
            180                 185                 190         


Ile Leu Gln Gly Val Thr Ser Trp Gly Leu Gly Cys Ala Arg Pro Asn 
        195                 200                 205             


Lys Pro Gly Val Tyr Val Arg Val Ser Arg Phe Val Thr Trp Ile Glu 
    210                 215                 220                 


Gly Val Met Arg 
225             


<210>  15
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  15
gcggcggcag tggtggcggc                                                   20


<210>  16
<211>  22
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  16
agtagatcgg acagattttg ct                                                22


<210>  17
<211>  24
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  17
gctgatgctt tgggaagtat gtta                                              24


<210>  18
<211>  20
<212>  DNA
<213>  ˹

<220>
<223>  

<400>  18
attccagatc tgtctgatcg                                                   20


