序列表

<110>  上海康景生物医药科技有限公司

<120>  生物大分子靶向特异性补体抑制剂及其制备方法与应用

<130>  0175-PA-002

<160>  68

<170>  PatentIn version 3.5

<210>  1
<211>  1200
<212>  DNA
<213>  人类（Homo sapiens）

<400>  1
atggggatct tactgggcct gctactcctg gggcacctaa cagtggacac ttatggccgt       60

cccatcctgg aagtgccaga gagtgtaaca ggaccttgga aaggggatgt gaatcttccc      120

tgcacctatg accccctgca aggctacacc caagtcttgg tgaagtggct ggtacaacgt      180

ggctcagacc ctgtcaccat ctttctacgt gactcttctg gagaccatat ccagcaggca      240

aagtaccagg gccgcctgca tgtgagccac aaggttccag gagatgtatc cctccaattg      300

agcaccctgg agatggatga ccggagccac tacacgtgtg aagtcacctg gcagactcct      360

gatggcaacc aagtcgtgag agataagatt actgagctcc gtgtccagaa actctctgtc      420

tccaagccca cagtgacaac tggcagcggt tatggcttca cggtgcccca gggaatgagg      480

attagccttc aatgccaggc tcggggttct cctcccatca gttatatttg gtataagcaa      540

cagactaata accaggaacc catcaaagta gcaaccctaa gtaccttact cttcaagcct      600

gcggtgatag ccgactcagg ctcctatttc tgcactgcca agggccaggt tggctctgag      660

cagcacagcg acattgtgaa gtttgtggtc aaagactcct caaagctact caagaccaag      720

actgaggcac ctacaaccat gacatacccc ttgaaagcaa catctacagt gaagcagtcc      780

tgggactgga ccactgacat ggatggctac cttggagaga ccagtgctgg gccaggaaag      840

agcctgcctg tctttgccat catcctcatc atctccttgt gctgtatggt ggtttttacc      900

atggcctata tcatgctctg tcggaagaca tcccaacaag agcatgtcta cgaagcagcc      960

agggcacatg ccagagaggc caacgactct ggagaaacca tgagggtggc catcttcgca     1020

agtggctgct ccagtgatga gccaacttcc cagaatctgg gcaacaacta ctctgatgag     1080

ccctgcatag gacaggagta ccagatcatc gcccagatca atggcaacta cgcccgcctg     1140

ctggacacag ttcctctgga ttatgagttt ctggccactg agggcaaaag tgtctgttaa     1200


<210>  2
<211>  399
<212>  PRT
<213>  人类（Homo sapiens）

<400>  2

Met Gly Ile Leu Leu Gly Leu Leu Leu Leu Gly His Leu Thr Val Asp 
1               5                   10                  15      


Thr Tyr Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro 
            20                  25                  30          


Trp Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly 
        35                  40                  45              


Tyr Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro 
    50                  55                  60                  


Val Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala 
65                  70                  75                  80  


Lys Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val 
                85                  90                  95      


Ser Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr 
            100                 105                 110         


Cys Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp 
        115                 120                 125             


Lys Ile Thr Glu Leu Arg Val Gln Lys Leu Ser Val Ser Lys Pro Thr 
    130                 135                 140                 


Val Thr Thr Gly Ser Gly Tyr Gly Phe Thr Val Pro Gln Gly Met Arg 
145                 150                 155                 160 


Ile Ser Leu Gln Cys Gln Ala Arg Gly Ser Pro Pro Ile Ser Tyr Ile 
                165                 170                 175     


Trp Tyr Lys Gln Gln Thr Asn Asn Gln Glu Pro Ile Lys Val Ala Thr 
            180                 185                 190         


Leu Ser Thr Leu Leu Phe Lys Pro Ala Val Ile Ala Asp Ser Gly Ser 
        195                 200                 205             


Tyr Phe Cys Thr Ala Lys Gly Gln Val Gly Ser Glu Gln His Ser Asp 
    210                 215                 220                 


Ile Val Lys Phe Val Val Lys Asp Ser Ser Lys Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Thr Glu Ala Pro Thr Thr Met Thr Tyr Pro Leu Lys Ala Thr Ser Thr 
                245                 250                 255     


Val Lys Gln Ser Trp Asp Trp Thr Thr Asp Met Asp Gly Tyr Leu Gly 
            260                 265                 270         


Glu Thr Ser Ala Gly Pro Gly Lys Ser Leu Pro Val Phe Ala Ile Ile 
        275                 280                 285             


Leu Ile Ile Ser Leu Cys Cys Met Val Val Phe Thr Met Ala Tyr Ile 
    290                 295                 300                 


Met Leu Cys Arg Lys Thr Ser Gln Gln Glu His Val Tyr Glu Ala Ala 
305                 310                 315                 320 


Arg Ala His Ala Arg Glu Ala Asn Asp Ser Gly Glu Thr Met Arg Val 
                325                 330                 335     


Ala Ile Phe Ala Ser Gly Cys Ser Ser Asp Glu Pro Thr Ser Gln Asn 
            340                 345                 350         


Leu Gly Asn Asn Tyr Ser Asp Glu Pro Cys Ile Gly Gln Glu Tyr Gln 
        355                 360                 365             


Ile Ile Ala Gln Ile Asn Gly Asn Tyr Ala Arg Leu Leu Asp Thr Val 
    370                 375                 380                 


Pro Leu Asp Tyr Glu Phe Leu Ala Thr Glu Gly Lys Ser Val Cys 
385                 390                 395                 


<210>  3
<211>  3696
<212>  DNA
<213>  人类（Homo sapiens）

<400>  3
atgagacttc tagcaaagat tatttgcctt atgttatggg ctatttgtgt agcagaagat       60

tgcaatgaac ttcctccaag aagaaataca gaaattctga caggttcctg gtctgaccaa      120

acatatccag aaggcaccca ggctatctat aaatgccgcc ctggatatag atctcttgga      180

aatgtaataa tggtatgcag gaagggagaa tgggttgctc ttaatccatt aaggaaatgt      240

cagaaaaggc cctgtggaca tcctggagat actccttttg gtacttttac ccttacagga      300

ggaaatgtgt ttgaatatgg tgtaaaagct gtgtatacat gtaatgaggg gtatcaattg      360

ctaggtgaga ttaattaccg tgaatgtgac acagatggat ggaccaatga tattcctata      420

tgtgaagttg tgaagtgttt accagtgaca gcaccagaga atggaaaaat tgtcagtagt      480

gcaatggaac cagatcggga ataccatttt ggacaagcag tacggtttgt atgtaactca      540

ggctacaaga ttgaaggaga tgaagaaatg cattgttcag acgatggttt ttggagtaaa      600

gagaaaccaa agtgtgtgga aatttcatgc aaatccccag atgttataaa tggatctcct      660

atatctcaga agattattta taaggagaat gaacgatttc aatataaatg taacatgggt      720

tatgaataca gtgaaagagg agatgctgta tgcactgaat ctggatggcg tccgttgcct      780

tcatgtgaag aaaaatcatg tgataatcct tatattccaa atggtgacta ctcaccttta      840

aggattaaac acagaactgg agatgaaatc acgtaccagt gtagaaatgg tttttatcct      900

gcaacccggg gaaatacagc aaaatgcaca agtactggct ggatacctgc tccgagatgt      960

accttgaaac cttgtgatta tccagacatt aaacatggag gtctatatca tgagaatatg     1020

cgtagaccat actttccagt agctgtagga aaatattact cctattactg tgatgaacat     1080

tttgagactc cgtcaggaag ttactgggat cacattcatt gcacacaaga tggatggtcg     1140

ccagcagtac catgcctcag aaaatgttat tttccttatt tggaaaatgg atataatcaa     1200

aatcatggaa gaaagtttgt acagggtaaa tctatagacg ttgcctgcca tcctggctac     1260

gctcttccaa aagcgcagac cacagttaca tgtatggaga atggctggtc tcctactccc     1320

agatgcatcc gtgtcaaaac atgttccaaa tcaagtatag atattgagaa tgggtttatt     1380

tctgaatctc agtatacata tgccttaaaa gaaaaagcga aatatcaatg caaactagga     1440

tatgtaacag cagatggtga aacatcagga tcaattacat gtgggaaaga tggatggtca     1500

gctcaaccca cgtgcattaa atcttgtgat atcccagtat ttatgaatgc cagaactaaa     1560

aatgacttca catggtttaa gctgaatgac acattggact atgaatgcca tgatggttat     1620

gaaagcaata ctggaagcac cactggttcc atagtgtgtg gttacaatgg ttggtctgat     1680

ttacccatat gttatgaaag agaatgcgaa cttcctaaaa tagatgtaca cttagttcct     1740

gatcgcaaga aagaccagta taaagttgga gaggtgttga aattctcctg caaaccagga     1800

tttacaatag ttggacctaa ttccgttcag tgctaccact ttggattgtc tcctgacctc     1860

ccaatatgta aagagcaagt acaatcatgt ggtccacctc ctgaactcct caatgggaat     1920

gttaaggaaa aaacgaaaga agaatatgga cacagtgaag tggtggaata ttattgcaat     1980

cctagatttc taatgaaggg acctaataaa attcaatgtg ttgatggaga gtggacaact     2040

ttaccagtgt gtattgtgga ggagagtacc tgtggagata tacctgaact tgaacatggc     2100

tgggcccagc tttcttcccc tccttattac tatggagatt cagtggaatt caattgctca     2160

gaatcattta caatgattgg acacagatca attacgtgta ttcatggagt atggacccaa     2220

cttccccagt gtgtggcaat agataaactt aagaagtgca aatcatcaaa tttaattata     2280

cttgaggaac atttaaaaaa caagaaggaa ttcgatcata attctaacat aaggtacaga     2340

tgtagaggaa aagaaggatg gatacacaca gtctgcataa atggaagatg ggatccagaa     2400

gtgaactgct caatggcaca aatacaatta tgcccacctc cacctcagat tcccaattct     2460

cacaatatga caaccacact gaattatcgg gatggagaaa aagtatctgt tctttgccaa     2520

gaaaattatc taattcagga aggagaagaa attacatgca aagatggaag atggcagtca     2580

ataccactct gtgttgaaaa aattccatgt tcacaaccac ctcagataga acacggaacc     2640

attaattcat ccaggtcttc acaagaaagt tatgcacatg ggactaaatt gagttatact     2700

tgtgagggtg gtttcaggat atctgaagaa aatgaaacaa catgctacat gggaaaatgg     2760

agttctccac ctcagtgtga aggccttcct tgtaaatctc cacctgagat ttctcatggt     2820

gttgtagctc acatgtcaga cagttatcag tatggagaag aagttacgta caaatgtttt     2880

gaaggttttg gaattgatgg gcctgcaatt gcaaaatgct taggagaaaa atggtctcac     2940

cctccatcat gcataaaaac agattgtctc agtttaccta gctttgaaaa tgccataccc     3000

atgggagaga agaaggatgt gtataaggcg ggtgagcaag tgacttacac ttgtgcaaca     3060

tattacaaaa tggatggagc cagtaatgta acatgcatta atagcagatg gacaggaagg     3120

ccaacatgca gagacacctc ctgtgtgaat ccgcccacag tacaaaatgc ttatatagtg     3180

tcgagacaga tgagtaaata tccatctggt gagagagtac gttatcaatg taggagccct     3240

tatgaaatgt ttggggatga agaagtgatg tgtttaaatg gaaactggac ggaaccacct     3300

caatgcaaag attctacagg aaaatgtggg ccccctccac ctattgacaa tggggacatt     3360

acttcattcc cgttgtcagt atatgctcca gcttcatcag ttgagtacca atgccagaac     3420

ttgtatcaac ttgagggtaa caagcgaata acatgtagaa atggacaatg gtcagaacca     3480

ccaaaatgct tacatccgtg tgtaatatcc cgagaaatta tggaaaatta taacatagca     3540

ttaaggtgga cagccaaaca gaagctttat tcgagaacag gtgaatcagt tgaatttgtg     3600

tgtaaacggg gatatcgtct ttcatcacgt tctcacacat tgcgaacaac atgttgggat     3660

gggaaactgg agtatccaac ttgtgcaaaa agatag                               3696


<210>  4
<211>  1231
<212>  PRT
<213>  人类（Homo sapiens）

<400>  4

Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys 
1               5                   10                  15      


Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 
            20                  25                  30          


Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 
        35                  40                  45              


Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 
    50                  55                  60                  


Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys 
65                  70                  75                  80  


Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 
                85                  90                  95      


Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 
            100                 105                 110         


Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 
        115                 120                 125             


Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 
    130                 135                 140                 


Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser 
145                 150                 155                 160 


Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 
                165                 170                 175     


Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 
            180                 185                 190         


Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 
        195                 200                 205             


Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 
    210                 215                 220                 


Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly 
225                 230                 235                 240 


Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 
                245                 250                 255     


Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 
            260                 265                 270         


Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 
        275                 280                 285             


Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 
    290                 295                 300                 


Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys 
305                 310                 315                 320 


Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 
                325                 330                 335     


His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 
            340                 345                 350         


Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 
        355                 360                 365             


Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 
    370                 375                 380                 


Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln 
385                 390                 395                 400 


Asn His Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 
                405                 410                 415     


His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 
            420                 425                 430         


Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 
        435                 440                 445             


Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 
    450                 455                 460                 


Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly 
465                 470                 475                 480 


Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 
                485                 490                 495     


Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 
            500                 505                 510         


Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 
        515                 520                 525             


Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 
    530                 535                 540                 


Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp 
545                 550                 555                 560 


Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 
                565                 570                 575     


His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 
            580                 585                 590         


Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 
        595                 600                 605             


Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 
    610                 615                 620                 


Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn 
625                 630                 635                 640 


Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 
                645                 650                 655     


Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 
            660                 665                 670         


Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 
        675                 680                 685             


Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 
    690                 695                 700                 


Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser 
705                 710                 715                 720 


Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 
                725                 730                 735     


Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 
            740                 745                 750         


Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 
        755                 760                 765             


Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 
    770                 775                 780                 


Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu 
785                 790                 795                 800 


Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 
                805                 810                 815     


Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 
            820                 825                 830         


Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 
        835                 840                 845             


Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 
    850                 855                 860                 


Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr 
865                 870                 875                 880 


Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 
                885                 890                 895     


Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 
            900                 905                 910         


Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 
        915                 920                 925             


Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 
    930                 935                 940                 


Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe 
945                 950                 955                 960 


Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 
                965                 970                 975     


Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 
            980                 985                 990         


Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 
        995                 1000                1005            


Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys Met 
    1010                1015                1020                


Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr Gly Arg 
1025                1030                1035                1040


Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn 
                1045                1050                1055    


Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg 
            1060                1065                1070        


Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu 
        1075                1080                1085            


Val Met Cys Leu Asn Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp 
    1090                1095                1100                


Ser Thr Gly Lys Cys Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile 
1105                1110                1115                1120


Thr Ser Phe Pro Leu Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr 
                1125                1130                1135    


Gln Cys Gln Asn Leu Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys 
            1140                1145                1150        


Arg Asn Gly Gln Trp Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val 
        1155                1160                1165            


Ile Ser Arg Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr 
    1170                1175                1180                


Ala Lys Gln Lys Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val 
1185                1190                1195                1200


Cys Lys Arg Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr 
                1205                1210                1215    


Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 
            1220                1225                1230    


<210>  5
<211>  357
<212>  DNA
<213>  人类（Homo sapiens）

<400>  5
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat       60

cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta      120

caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag      180

caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc      240

caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag      300

actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaa         357


<210>  6
<211>  119
<212>  PRT
<213>  人类（Homo sapiens）

<400>  6

Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      


Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          


Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              


Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  


Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         


Thr Glu Leu Arg Val Gln Lys 
        115                 


<210>  7
<211>  915
<212>  DNA
<213>  人类（Homo sapiens）

<400>  7
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct       60

gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      120

cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      180

aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      240

acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      300

caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      360

cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      420

agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      480

aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      540

agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      600

tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac      660

atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg      720

ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca      780

cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt      840

tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg      900

agatgtacct tgaaa                                                       915


<210>  8
<211>  305
<212>  PRT
<213>  人类（Homo sapiens）

<400>  8

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys 
305 


<210>  9
<211>  675
<212>  DNA
<213>  人类（Homo sapiens）

<400>  9
cccccatgcc catcatgccc agcacctgag ttcctggggg gaccatcagt cttcctgttc       60

cccccaaaac ccaaggacac tctcatgatc tcccggaccc ctgaggtcac gtgcgtggtg      120

gtggacgtga gccaggaaga ccccgaggtc cagttcaact ggtacgtgga tggcgtggag      180

gtgcataatg ccaagacaaa gccgcgggag gagcagttca acagcacgta ccgtgtggtc      240

agcgtcctca ccgtcctgca ccaggactgg ctgaacggca aggagtacaa gtgcaaggtc      300

tccaacaaag gcctcccgtc ctccatcgag aaaaccatct ccaaagccaa agggcagccc      360

cgagagccac aggtgtacac cctgccccca tcccaggagg agatgaccaa gaaccaggtc      420

agcctgacct gcctggtcaa aggcttctac cccagcgaca tcgccgtgga gtgggagagc      480

aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc      540

ttcttcctct acagcaggct aaccgtggac aagagcaggt ggcaggaggg gaatgtcttc      600

tcatgctccg tgatgcatga ggctctgcac aaccactaca cacagaagag cctctccctg      660

tctctgggta aataa                                                       675


<210>  10
<211>  224
<212>  PRT
<213>  人类（Homo sapiens）

<400>  10

Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
1               5                   10                  15      


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            20                  25                  30          


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
        35                  40                  45              


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    50                  55                  60                  


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
65                  70                  75                  80  


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                85                  90                  95      


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
            100                 105                 110         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        115                 120                 125             


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    130                 135                 140                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
145                 150                 155                 160 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                165                 170                 175     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
            180                 185                 190         


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        195                 200                 205             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    210                 215                 220                 


<210>  11
<211>  1758
<212>  DNA
<213>  人类（Homo sapiens）

<400>  11
gatgcacaca agagtgaggt tgctcatcgg tttaaagatt tgggagaaga aaatttcaaa       60

gccttggtgt tgattgcctt tgctcagtat cttcagcagt gtccatttga agatcatgta      120

aaattagtga atgaagtaac tgaatttgca aaaacatgtg ttgctgatga gtcagctgaa      180

aattgtgaca aatcacttca tacccttttt ggagacaaat tatgcacagt tgcaactctt      240

cgtgaaacct atggtgaaat ggctgactgc tgtgcaaaac aagaacctga gagaaatgaa      300

tgcttcttgc aacacaaaga tgacaaccca aacctccccc gattggtgag accagaggtt      360

gatgtgatgt gcactgcttt tcatgacaat gaagagacat ttttgaaaaa atacttatat      420

gaaattgcca gaagacatcc ttacttttat gccccggaac tccttttctt tgctaaaagg      480

tataaagctg cttttacaga atgttgccaa gctgctgata aagctgcctg cctgttgcca      540

aagctcgatg aacttcggga tgaagggaag gcttcgtctg ccaaacagag actcaagtgt      600

gccagtctcc aaaaatttgg agaaagagct ttcaaagcat gggcagtagc tcgcctgagc      660

cagagatttc ccaaagctga gtttgcagaa gtttccaagt tagtgacaga tcttaccaaa      720

gtccacacgg aatgctgcca tggagatctg cttgaatgtg ctgatgacag ggcggacctt      780

gccaagtata tctgtgaaaa tcaagattcg atctccagta aactgaagga atgctgtgaa      840

aaacctctgt tggaaaaatc ccactgcatt gccgaagtgg aaaatgatga gatgcctgct      900

gacttgcctt cattagctgc tgattttgtt gaaagtaagg atgtttgcaa aaactatgct      960

gaggcaaagg atgtcttcct gggcatgttt ttgtatgaat atgcaagaag gcatcctgat     1020

tactctgtcg tgctgctgct gagacttgcc aagacatatg aaaccactct agagaagtgc     1080

tgtgccgctg cagatcctca tgaatgctat gccaaagtgt tcgatgaatt taaacctctt     1140

gtggaagagc ctcagaattt aatcaaacaa aattgtgagc tttttgagca gcttggagag     1200

tacaaattcc agaatgcgct attagttcgt tacaccaaga aagtacccca agtgtcaact     1260

ccaactcttg tagaggtctc aagaaaccta ggaaaagtgg gcagcaaatg ttgtaaacat     1320

cctgaagcaa aaagaatgcc ctgtgcagaa gactatctat ccgtggtcct gaaccagtta     1380

tgtgtgttgc atgagaaaac gccagtaagt gacagagtca ccaaatgctg cacagaatcc     1440

ttggtgaaca ggcgaccatg cttttcagct ctggaagtcg atgaaacata cgttcccaaa     1500

gagtttaatg ctgaaacatt caccttccat gcagatatat gcacactttc tgagaaggag     1560

agacaaatca agaaacaaac tgcacttgtt gagctcgtga aacacaagcc caaggcaaca     1620

aaagagcaac tgaaagctgt tatggatgat ttcgcagctt ttgtagagaa gtgctgcaag     1680

gctgacgata aggagacctg ctttgccgag gagggtaaaa aacttgttgc tgcaagtcaa     1740

gctgccttag gcttataa                                                   1758


<210>  12
<211>  585
<212>  PRT
<213>  人类（Homo sapiens）

<400>  12

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  13
<211>  1950
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH-IgG4 Fc核酸序列

<400>  13
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct      420

gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      480

cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      540

aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      600

acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      660

caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      720

cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      780

agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      840

aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      900

agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      960

tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac     1020

atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg     1080

ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca     1140

cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt     1200

tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg     1260

agatgtacct tgaaaccccc atgcccatca tgcccagcac ctgagttcct ggggggacca     1320

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag     1380

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac     1440

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc     1500

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag     1560

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa     1620

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg     1680

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc     1740

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1800

gactccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag     1860

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag     1920

aagagcctct ccctgtctct gggtaaataa                                      1950


<210>  14
<211>  649
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH-IgG4 Fc蛋白序列

<400>  14

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Glu Asp Cys Asn Glu Leu Pro Pro 
        115                 120                 125             


Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr 
    130                 135                 140                 


Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser 
145                 150                 155                 160 


Leu Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu 
                165                 170                 175     


Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp 
            180                 185                 190         


Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr 
        195                 200                 205             


Gly Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly 
    210                 215                 220                 


Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile 
225                 230                 235                 240 


Pro Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn 
                245                 250                 255     


Gly Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe 
            260                 265                 270         


Gly Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly 
        275                 280                 285             


Asp Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys 
    290                 295                 300                 


Pro Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly 
305                 310                 315                 320 


Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln 
                325                 330                 335     


Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val 
            340                 345                 350         


Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser 
        355                 360                 365             


Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile 
    370                 375                 380                 


Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe 
385                 390                 395                 400 


Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp 
                405                 410                 415     


Ile Pro Ala Pro Arg Cys Thr Leu Lys Pro Pro Cys Pro Ser Cys Pro 
            420                 425                 430         


Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
        435                 440                 445             


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
    450                 455                 460                 


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
465                 470                 475                 480 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
                485                 490                 495     


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
            500                 505                 510         


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
        515                 520                 525             


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
    530                 535                 540                 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met 
545                 550                 555                 560 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
                565                 570                 575     


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
            580                 585                 590         


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
        595                 600                 605             


Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val 
    610                 615                 620                 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
625                 630                 635                 640 


Lys Ser Leu Ser Leu Ser Leu Gly Lys 
                645                 


<210>  15
<211>  3030
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH-HSA核酸序列

<400>  15
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat       60

cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta      120

caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag      180

caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc      240

caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag      300

actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaagaa      360

gattgcaatg aacttcctcc aagaagaaat acagaaattc tgacaggttc ctggtctgac      420

caaacatatc cagaaggcac ccaggctatc tataaatgcc gccctggata tagatctctt      480

ggaaatgtaa taatggtatg caggaaggga gaatgggttg ctcttaatcc attaaggaaa      540

tgtcagaaaa ggccctgtgg acatcctgga gatactcctt ttggtacttt tacccttaca      600

ggaggaaatg tgtttgaata tggtgtaaaa gctgtgtata catgtaatga ggggtatcaa      660

ttgctaggtg agattaatta ccgtgaatgt gacacagatg gatggaccaa tgatattcct      720

atatgtgaag ttgtgaagtg tttaccagtg acagcaccag agaatggaaa aattgtcagt      780

agtgcaatgg aaccagatcg ggaataccat tttggacaag cagtacggtt tgtatgtaac      840

tcaggctaca agattgaagg agatgaagaa atgcattgtt cagacgatgg tttttggagt      900

aaagagaaac caaagtgtgt ggaaatttca tgcaaatccc cagatgttat aaatggatct      960

cctatatctc agaagattat ttataaggag aatgaacgat ttcaatataa atgtaacatg     1020

ggttatgaat acagtgaaag aggagatgct gtatgcactg aatctggatg gcgtccgttg     1080

ccttcatgtg aagaaaaatc atgtgataat ccttatattc caaatggtga ctactcacct     1140

ttaaggatta aacacagaac tggagatgaa atcacgtacc agtgtagaaa tggtttttat     1200

cctgcaaccc ggggaaatac agcaaaatgc acaagtactg gctggatacc tgctccgaga     1260

tgtaccttga aagatgcaca caagagtgag gttgctcatc ggtttaaaga tttgggagaa     1320

gaaaatttca aagccttggt gttgattgcc tttgctcagt atcttcagca gtgtccattt     1380

gaagatcatg taaaattagt gaatgaagta actgaatttg caaaaacatg tgttgctgat     1440

gagtcagctg aaaattgtga caaatcactt catacccttt ttggagacaa attatgcaca     1500

gttgcaactc ttcgtgaaac ctatggtgaa atggctgact gctgtgcaaa acaagaacct     1560

gagagaaatg aatgcttctt gcaacacaaa gatgacaacc caaacctccc ccgattggtg     1620

agaccagagg ttgatgtgat gtgcactgct tttcatgaca atgaagagac atttttgaaa     1680

aaatacttat atgaaattgc cagaagacat ccttactttt atgccccgga actccttttc     1740

tttgctaaaa ggtataaagc tgcttttaca gaatgttgcc aagctgctga taaagctgcc     1800

tgcctgttgc caaagctcga tgaacttcgg gatgaaggga aggcttcgtc tgccaaacag     1860

agactcaagt gtgccagtct ccaaaaattt ggagaaagag ctttcaaagc atgggcagta     1920

gctcgcctga gccagagatt tcccaaagct gagtttgcag aagtttccaa gttagtgaca     1980

gatcttacca aagtccacac ggaatgctgc catggagatc tgcttgaatg tgctgatgac     2040

agggcggacc ttgccaagta tatctgtgaa aatcaagatt cgatctccag taaactgaag     2100

gaatgctgtg aaaaacctct gttggaaaaa tcccactgca ttgccgaagt ggaaaatgat     2160

gagatgcctg ctgacttgcc ttcattagct gctgattttg ttgaaagtaa ggatgtttgc     2220

aaaaactatg ctgaggcaaa ggatgtcttc ctgggcatgt ttttgtatga atatgcaaga     2280

aggcatcctg attactctgt cgtgctgctg ctgagacttg ccaagacata tgaaaccact     2340

ctagagaagt gctgtgccgc tgcagatcct catgaatgct atgccaaagt gttcgatgaa     2400

tttaaacctc ttgtggaaga gcctcagaat ttaatcaaac aaaattgtga gctttttgag     2460

cagcttggag agtacaaatt ccagaatgcg ctattagttc gttacaccaa gaaagtaccc     2520

caagtgtcaa ctccaactct tgtagaggtc tcaagaaacc taggaaaagt gggcagcaaa     2580

tgttgtaaac atcctgaagc aaaaagaatg ccctgtgcag aagactatct atccgtggtc     2640

ctgaaccagt tatgtgtgtt gcatgagaaa acgccagtaa gtgacagagt caccaaatgc     2700

tgcacagaat ccttggtgaa caggcgacca tgcttttcag ctctggaagt cgatgaaaca     2760

tacgttccca aagagtttaa tgctgaaaca ttcaccttcc atgcagatat atgcacactt     2820

tctgagaagg agagacaaat caagaaacaa actgcacttg ttgagctcgt gaaacacaag     2880

cccaaggcaa caaaagagca actgaaagct gttatggatg atttcgcagc ttttgtagag     2940

aagtgctgca aggctgacga taaggagacc tgctttgccg aggagggtaa aaaacttgtt     3000

gctgcaagtc aagctgcctt aggcttataa                                      3030


<210>  16
<211>  1009
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH-HSA蛋白序列

<400>  16

Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      


Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          


Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              


Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  


Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         


Thr Glu Leu Arg Val Gln Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg 
        115                 120                 125             


Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro 
    130                 135                 140                 


Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu 
145                 150                 155                 160 


Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn 
                165                 170                 175     


Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr 
            180                 185                 190         


Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly 
        195                 200                 205             


Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu 
    210                 215                 220                 


Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro 
225                 230                 235                 240 


Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly 
                245                 250                 255     


Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly 
            260                 265                 270         


Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp 
        275                 280                 285             


Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro 
    290                 295                 300                 


Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser 
305                 310                 315                 320 


Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr 
                325                 330                 335     


Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys 
            340                 345                 350         


Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys 
        355                 360                 365             


Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys 
    370                 375                 380                 


His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr 
385                 390                 395                 400 


Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile 
                405                 410                 415     


Pro Ala Pro Arg Cys Thr Leu Lys Asp Ala His Lys Ser Glu Val Ala 
            420                 425                 430         


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        435                 440                 445             


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    450                 455                 460                 


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
465                 470                 475                 480 


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                485                 490                 495     


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            500                 505                 510         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        515                 520                 525             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    530                 535                 540                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
545                 550                 555                 560 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                565                 570                 575     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            580                 585                 590         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        595                 600                 605             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    610                 615                 620                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
625                 630                 635                 640 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                645                 650                 655     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            660                 665                 670         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        675                 680                 685             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    690                 695                 700                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
705                 710                 715                 720 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                725                 730                 735     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            740                 745                 750         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        755                 760                 765             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    770                 775                 780                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
785                 790                 795                 800 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                805                 810                 815     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            820                 825                 830         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        835                 840                 845             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    850                 855                 860                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
865                 870                 875                 880 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                885                 890                 895     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            900                 905                 910         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        915                 920                 925             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    930                 935                 940                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
945                 950                 955                 960 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                965                 970                 975     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            980                 985                 990         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        995                 1000                1005            


Leu 
    


<210>  17
<211>  1041
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD55核酸序列

<400>  17
gactgtggcc ttcccccaga tgtacctaat gcccagccag ctttggaagg ccgtacaagt       60

tttcccgagg atactgtaat aacgtacaaa tgtgaagaaa gctttgtgaa aattcctggc      120

gagaaggact cagtgatctg ccttaagggc agtcaatggt cagatattga agagttctgc      180

aatcgtagct gcgaggtgcc aacaaggcta aattctgcat ccctcaaaca gccttatatc      240

actcagaatt attttccagt cggtactgtt gtggaatatg agtgccgtcc aggttacaga      300

agagaacctt ctctatcacc aaaactaact tgccttcaga atttaaaatg gtccacagca      360

gtcgaatttt gtaaaaagaa atcatgccct aatccgggag aaatacgaaa tggtcagatt      420

gatgtaccag gtggcatatt atttggtgca accatctcct tctcatgtaa cacagggtac      480

aaattatttg gctcgacttc tagtttttgt cttatttcag gcagctctgt ccagtggagt      540

gacccgttgc cagagtgcag agaaatttat tgtccagcac caccacaaat tgacaatgga      600

ataattcaag gggaacgtga ccattatgga tatagacagt ctgtaacgta tgcatgtaat      660

aaaggattca ccatgattgg agagcactct atttattgta ctgtgaataa tgatgaagga      720

gagtggagtg gcccaccacc tgaatgcaga ggaaaatctc taacttccaa ggtcccacca      780

acagttcaga aacctaccac agtaaatgtt ccaactacag aagtctcacc aacttctcag      840

aaaaccacca caaaaaccac cacaccaaat gctcaagcaa cacggagtac acctgtttcc      900

aggacaacca agcattttca tgaaacaacc ccaaataaag gaagtggaac cacttcaggt      960

actacccgtc ttctatctgg gcacacgtgt ttcacgttga caggtttgct tgggacgcta     1020

gtaaccatgg gcttgctgac t                                               1041


<210>  18
<211>  347
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD55蛋白序列

<400>  18

Asp Cys Gly Leu Pro Pro Asp Val Pro Asn Ala Gln Pro Ala Leu Glu 
1               5                   10                  15      


Gly Arg Thr Ser Phe Pro Glu Asp Thr Val Ile Thr Tyr Lys Cys Glu 
            20                  25                  30          


Glu Ser Phe Val Lys Ile Pro Gly Glu Lys Asp Ser Val Ile Cys Leu 
        35                  40                  45              


Lys Gly Ser Gln Trp Ser Asp Ile Glu Glu Phe Cys Asn Arg Ser Cys 
    50                  55                  60                  


Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys Gln Pro Tyr Ile 
65                  70                  75                  80  


Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu Tyr Glu Cys Arg 
                85                  90                  95      


Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys Leu Thr Cys Leu 
            100                 105                 110         


Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys Lys Lys Lys Ser 
        115                 120                 125             


Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile Asp Val Pro Gly 
    130                 135                 140                 


Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys Asn Thr Gly Tyr 
145                 150                 155                 160 


Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile Ser Gly Ser Ser 
                165                 170                 175     


Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu Ile Tyr Cys Pro 
            180                 185                 190         


Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly Glu Arg Asp His 
        195                 200                 205             


Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn Lys Gly Phe Thr 
    210                 215                 220                 


Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn Asn Asp Glu Gly 
225                 230                 235                 240 


Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg Gly Lys Ser Leu Thr Ser 
                245                 250                 255     


Lys Val Pro Pro Thr Val Gln Lys Pro Thr Thr Val Asn Val Pro Thr 
            260                 265                 270         


Thr Glu Val Ser Pro Thr Ser Gln Lys Thr Thr Thr Lys Thr Thr Thr 
        275                 280                 285             


Pro Asn Ala Gln Ala Thr Arg Ser Thr Pro Val Ser Arg Thr Thr Lys 
    290                 295                 300                 


His Phe His Glu Thr Thr Pro Asn Lys Gly Ser Gly Thr Thr Ser Gly 
305                 310                 315                 320 


Thr Thr Arg Leu Leu Ser Gly His Thr Cys Phe Thr Leu Thr Gly Leu 
                325                 330                 335     


Leu Gly Thr Leu Val Thr Met Gly Leu Leu Thr 
            340                 345         


<210>  19
<211>  1074
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD46核酸序列

<400>  19
tgtgaggagc caccaacatt tgaagctatg gagctcattg gtaaaccaaa accctactat       60

gagattggtg aacgagtaga ttataagtgt aaaaaaggat acttctatat acctcctctt      120

gccacccata ctatttgtga tcggaatcat acatggctac ctgtctcaga tgacgcctgt      180

tatagagaaa catgtccata tatacgggat cctttaaatg gccaagcagt ccctgcaaat      240

gggacttacg agtttggtta tcagatgcac tttatttgta atgagggtta ttacttaatt      300

ggtgaagaaa ttctatattg tgaacttaaa ggatcagtag caatttggag cggtaagccc      360

ccaatatgtg aaaaggtttt gtgtacacca cctccaaaaa taaaaaatgg aaaacacacc      420

tttagtgaag tagaagtatt tgagtatctt gatgcagtaa cttatagttg tgatcctgca      480

cctggaccag atccattttc acttattgga gagagcacga tttattgtgg tgacaattca      540

gtgtggagtc gtgctgctcc agagtgtaaa gtggtcaaat gtcgatttcc agtagtcgaa      600

aatggaaaac agatatcagg atttggaaaa aaattttact acaaagcaac agttatgttt      660

gaatgcgata agggttttta cctcgatggc agcgacacaa ttgtctgtga cagtaacagt      720

acttgggatc ccccagttcc aaagtgtctt aaagtgctgc ctccatctag tacaaaacct      780

ccagctttga gtcattcagt gtcgacttct tccactacaa aatctccagc gtccagtgcc      840

tcaggtccta ggcctactta caagcctcca gtctcaaatt atccaggata tcctaaacct      900

gaggaaggaa tacttgacag tttggatgtt tgggtcattg ctgtgattgt tattgccata      960

gttgttggag ttgcagtaat ttgtgttgtc ccgtacagat atcttcaaag gaggaagaag     1020

aaaggcacat acctaactga tgagacccac agagaagtaa aatttacttc tctc           1074


<210>  20
<211>  358
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD46蛋白序列

<400>  20

Cys Glu Glu Pro Pro Thr Phe Glu Ala Met Glu Leu Ile Gly Lys Pro 
1               5                   10                  15      


Lys Pro Tyr Tyr Glu Ile Gly Glu Arg Val Asp Tyr Lys Cys Lys Lys 
            20                  25                  30          


Gly Tyr Phe Tyr Ile Pro Pro Leu Ala Thr His Thr Ile Cys Asp Arg 
        35                  40                  45              


Asn His Thr Trp Leu Pro Val Ser Asp Asp Ala Cys Tyr Arg Glu Thr 
    50                  55                  60                  


Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala Val Pro Ala Asn 
65                  70                  75                  80  


Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile Cys Asn Glu Gly 
                85                  90                  95      


Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu Leu Lys Gly Ser 
            100                 105                 110         


Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu Lys Val Leu Cys 
        115                 120                 125             


Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr Phe Ser Glu Val 
    130                 135                 140                 


Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser Cys Asp Pro Ala 
145                 150                 155                 160 


Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser Thr Ile Tyr Cys 
                165                 170                 175     


Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu Cys Lys Val Val 
            180                 185                 190         


Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln Ile Ser Gly Phe 
        195                 200                 205             


Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe Glu Cys Asp Lys 
    210                 215                 220                 


Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys Asp Ser Asn Ser 
225                 230                 235                 240 


Thr Trp Asp Pro Pro Val Pro Lys Cys Leu Lys Val Leu Pro Pro Ser 
                245                 250                 255     


Ser Thr Lys Pro Pro Ala Leu Ser His Ser Val Ser Thr Ser Ser Thr 
            260                 265                 270         


Thr Lys Ser Pro Ala Ser Ser Ala Ser Gly Pro Arg Pro Thr Tyr Lys 
        275                 280                 285             


Pro Pro Val Ser Asn Tyr Pro Gly Tyr Pro Lys Pro Glu Glu Gly Ile 
    290                 295                 300                 


Leu Asp Ser Leu Asp Val Trp Val Ile Ala Val Ile Val Ile Ala Ile 
305                 310                 315                 320 


Val Val Gly Val Ala Val Ile Cys Val Val Pro Tyr Arg Tyr Leu Gln 
                325                 330                 335     


Arg Arg Lys Lys Lys Gly Thr Tyr Leu Thr Asp Glu Thr His Arg Glu 
            340                 345                 350         


Val Lys Phe Thr Ser Leu 
        355             


<210>  21
<211>  309
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD59核酸序列

<400>  21
ctgcagtgct acaactgtcc taacccaact gctgactgca aaacagccgt caattgttca       60

tctgattttg atgcgtgtct cattaccaaa gctgggttac aagtgtataa caagtgttgg      120

aagtttgagc attgcaattt caacgacgtc acaacccgct tgagggaaaa tgagctaacg      180

tactactgct gcaagaagga cctgtgtaac tttaacgaac agcttgaaaa tggtgggaca      240

tccttatcag agaaaacagt tcttctgctg gtgactccat ttctggcagc agcctggagc      300

cttcatccc                                                              309


<210>  22
<211>  103
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CD59蛋白序列

<400>  22

Leu Gln Cys Tyr Asn Cys Pro Asn Pro Thr Ala Asp Cys Lys Thr Ala 
1               5                   10                  15      


Val Asn Cys Ser Ser Asp Phe Asp Ala Cys Leu Ile Thr Lys Ala Gly 
            20                  25                  30          


Leu Gln Val Tyr Asn Lys Cys Trp Lys Phe Glu His Cys Asn Phe Asn 
        35                  40                  45              


Asp Val Thr Thr Arg Leu Arg Glu Asn Glu Leu Thr Tyr Tyr Cys Cys 
    50                  55                  60                  


Lys Lys Asp Leu Cys Asn Phe Asn Glu Gln Leu Glu Asn Gly Gly Thr 
65                  70                  75                  80  


Ser Leu Ser Glu Lys Thr Val Leu Leu Leu Val Thr Pro Phe Leu Ala 
                85                  90                  95      


Ala Ala Trp Ser Leu His Pro 
            100             


<210>  23
<211>  2076
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD55-IgG4Fc核酸序列

<400>  23
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

gactgtggcc ttcccccaga tgtacctaat gcccagccag ctttggaagg ccgtacaagt      420

tttcccgagg atactgtaat aacgtacaaa tgtgaagaaa gctttgtgaa aattcctggc      480

gagaaggact cagtgatctg ccttaagggc agtcaatggt cagatattga agagttctgc      540

aatcgtagct gcgaggtgcc aacaaggcta aattctgcat ccctcaaaca gccttatatc      600

actcagaatt attttccagt cggtactgtt gtggaatatg agtgccgtcc aggttacaga      660

agagaacctt ctctatcacc aaaactaact tgccttcaga atttaaaatg gtccacagca      720

gtcgaatttt gtaaaaagaa atcatgccct aatccgggag aaatacgaaa tggtcagatt      780

gatgtaccag gtggcatatt atttggtgca accatctcct tctcatgtaa cacagggtac      840

aaattatttg gctcgacttc tagtttttgt cttatttcag gcagctctgt ccagtggagt      900

gacccgttgc cagagtgcag agaaatttat tgtccagcac caccacaaat tgacaatgga      960

ataattcaag gggaacgtga ccattatgga tatagacagt ctgtaacgta tgcatgtaat     1020

aaaggattca ccatgattgg agagcactct atttattgta ctgtgaataa tgatgaagga     1080

gagtggagtg gcccaccacc tgaatgcaga ggaaaatctc taacttccaa ggtcccacca     1140

acagttcaga aacctaccac agtaaatgtt ccaactacag aagtctcacc aacttctcag     1200

aaaaccacca caaaaaccac cacaccaaat gctcaagcaa cacggagtac acctgtttcc     1260

aggacaacca agcattttca tgaaacaacc ccaaataaag gaagtggaac cacttcaggt     1320

actacccgtc ttctatctgg gcacacgtgt ttcacgttga caggtttgct tgggacgcta     1380

gtaaccatgg gcttgctgac tcccccatgc ccatcatgcc cagcacctga gttcctgggg     1440

ggaccatcag tcttcctgtt ccccccaaaa cccaaggaca ctctcatgat ctcccggacc     1500

cctgaggtca cgtgcgtggt ggtggacgtg agccaggaag accccgaggt ccagttcaac     1560

tggtacgtgg atggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagttc     1620

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaacggc     1680

aaggagtaca agtgcaaggt ctccaacaaa ggcctcccgt cctccatcga gaaaaccatc     1740

tccaaagcca aagggcagcc ccgagagcca caggtgtaca ccctgccccc atcccaggag     1800

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta ccccagcgac     1860

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1920

gtgctggact ccgacggctc cttcttcctc tacagcaggc taaccgtgga caagagcagg     1980

tggcaggagg ggaatgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     2040

acacagaaga gcctctccct gtctctgggt aaataa                               2076


<210>  24
<211>  691
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD55-IgG4Fc蛋白序列

<400>  24

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Asp Cys Gly Leu Pro Pro Asp Val 
        115                 120                 125             


Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp 
    130                 135                 140                 


Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val Lys Ile Pro Gly 
145                 150                 155                 160 


Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile 
                165                 170                 175     


Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr Arg Leu Asn Ser 
            180                 185                 190         


Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly 
        195                 200                 205             


Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser 
    210                 215                 220                 


Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala 
225                 230                 235                 240 


Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg 
                245                 250                 255     


Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile 
            260                 265                 270         


Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser 
        275                 280                 285             


Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser Asp Pro Leu Pro 
    290                 295                 300                 


Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly 
305                 310                 315                 320 


Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr 
                325                 330                 335     


Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr 
            340                 345                 350         


Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu 
        355                 360                 365             


Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro Thr Val Gln Lys 
    370                 375                 380                 


Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser Pro Thr Ser Gln 
385                 390                 395                 400 


Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser 
                405                 410                 415     


Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr Thr Pro Asn 
            420                 425                 430         


Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His 
        435                 440                 445             


Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly 
    450                 455                 460                 


Leu Leu Thr Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly 
465                 470                 475                 480 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
                485                 490                 495     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
            500                 505                 510         


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        515                 520                 525             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
    530                 535                 540                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
545                 550                 555                 560 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
                565                 570                 575     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            580                 585                 590         


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
        595                 600                 605             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    610                 615                 620                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
625                 630                 635                 640 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
                645                 650                 655     


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
            660                 665                 670         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        675                 680                 685             


Leu Gly Lys 
    690     


<210>  25
<211>  2109
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD46-IgG4Fc核酸序列

<400>  25
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

tgtgaggagc caccaacatt tgaagctatg gagctcattg gtaaaccaaa accctactat      420

gagattggtg aacgagtaga ttataagtgt aaaaaaggat acttctatat acctcctctt      480

gccacccata ctatttgtga tcggaatcat acatggctac ctgtctcaga tgacgcctgt      540

tatagagaaa catgtccata tatacgggat cctttaaatg gccaagcagt ccctgcaaat      600

gggacttacg agtttggtta tcagatgcac tttatttgta atgagggtta ttacttaatt      660

ggtgaagaaa ttctatattg tgaacttaaa ggatcagtag caatttggag cggtaagccc      720

ccaatatgtg aaaaggtttt gtgtacacca cctccaaaaa taaaaaatgg aaaacacacc      780

tttagtgaag tagaagtatt tgagtatctt gatgcagtaa cttatagttg tgatcctgca      840

cctggaccag atccattttc acttattgga gagagcacga tttattgtgg tgacaattca      900

gtgtggagtc gtgctgctcc agagtgtaaa gtggtcaaat gtcgatttcc agtagtcgaa      960

aatggaaaac agatatcagg atttggaaaa aaattttact acaaagcaac agttatgttt     1020

gaatgcgata agggttttta cctcgatggc agcgacacaa ttgtctgtga cagtaacagt     1080

acttgggatc ccccagttcc aaagtgtctt aaagtgctgc ctccatctag tacaaaacct     1140

ccagctttga gtcattcagt gtcgacttct tccactacaa aatctccagc gtccagtgcc     1200

tcaggtccta ggcctactta caagcctcca gtctcaaatt atccaggata tcctaaacct     1260

gaggaaggaa tacttgacag tttggatgtt tgggtcattg ctgtgattgt tattgccata     1320

gttgttggag ttgcagtaat ttgtgttgtc ccgtacagat atcttcaaag gaggaagaag     1380

aaaggcacat acctaactga tgagacccac agagaagtaa aatttacttc tctcccccca     1440

tgcccatcat gcccagcacc tgagttcctg gggggaccat cagtcttcct gttcccccca     1500

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac     1560

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat     1620

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc     1680

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac     1740

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1800

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1860

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1920

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1980

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     2040

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     2100

ggtaaataa                                                             2109


<210>  26
<211>  702
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD46-IgG4Fc蛋白序列

<400>  26

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Cys Glu Glu Pro Pro Thr Phe Glu 
        115                 120                 125             


Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu 
    130                 135                 140                 


Arg Val Asp Tyr Lys Cys Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu 
145                 150                 155                 160 


Ala Thr His Thr Ile Cys Asp Arg Asn His Thr Trp Leu Pro Val Ser 
                165                 170                 175     


Asp Asp Ala Cys Tyr Arg Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu 
            180                 185                 190         


Asn Gly Gln Ala Val Pro Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln 
        195                 200                 205             


Met His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile 
    210                 215                 220                 


Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Ile Trp Ser Gly Lys Pro 
225                 230                 235                 240 


Pro Ile Cys Glu Lys Val Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn 
                245                 250                 255     


Gly Lys His Thr Phe Ser Glu Val Glu Val Phe Glu Tyr Leu Asp Ala 
            260                 265                 270         


Val Thr Tyr Ser Cys Asp Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu 
        275                 280                 285             


Ile Gly Glu Ser Thr Ile Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg 
    290                 295                 300                 


Ala Ala Pro Glu Cys Lys Val Val Lys Cys Arg Phe Pro Val Val Glu 
305                 310                 315                 320 


Asn Gly Lys Gln Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala 
                325                 330                 335     


Thr Val Met Phe Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp 
            340                 345                 350         


Thr Ile Val Cys Asp Ser Asn Ser Thr Trp Asp Pro Pro Val Pro Lys 
        355                 360                 365             


Cys Leu Lys Val Leu Pro Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser 
    370                 375                 380                 


His Ser Val Ser Thr Ser Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala 
385                 390                 395                 400 


Ser Gly Pro Arg Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly 
                405                 410                 415     


Tyr Pro Lys Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val 
            420                 425                 430         


Ile Ala Val Ile Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys 
        435                 440                 445             


Val Val Pro Tyr Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr 
    450                 455                 460                 


Leu Thr Asp Glu Thr His Arg Glu Val Lys Phe Thr Ser Leu Pro Pro 
465                 470                 475                 480 


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
                485                 490                 495     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            500                 505                 510         


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
        515                 520                 525             


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    530                 535                 540                 


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
545                 550                 555                 560 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                565                 570                 575     


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
            580                 585                 590         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        595                 600                 605             


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    610                 615                 620                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
625                 630                 635                 640 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                645                 650                 655     


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
            660                 665                 670         


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        675                 680                 685             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    690                 695                 700         


<210>  27
<211>  1344
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD59-IgG4Fc核酸序列

<400>  27
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

ctgcagtgct acaactgtcc taacccaact gctgactgca aaacagccgt caattgttca      420

tctgattttg atgcgtgtct cattaccaaa gctgggttac aagtgtataa caagtgttgg      480

aagtttgagc attgcaattt caacgacgtc acaacccgct tgagggaaaa tgagctaacg      540

tactactgct gcaagaagga cctgtgtaac tttaacgaac agcttgaaaa tggtgggaca      600

tccttatcag agaaaacagt tcttctgctg gtgactccat ttctggcagc agcctggagc      660

cttcatcccc ccccatgccc atcatgccca gcacctgagt tcctgggggg accatcagtc      720

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      780

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      840

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      900

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      960

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1020

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1080

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1140

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1200

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1260

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1320

ctctccctgt ctctgggtaa ataa                                            1344


<210>  28
<211>  447
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD59-IgG4Fc蛋白序列

<400>  28

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Leu Gln Cys Tyr Asn Cys Pro Asn 
        115                 120                 125             


Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe Asp 
    130                 135                 140                 


Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys Trp 
145                 150                 155                 160 


Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg Glu 
                165                 170                 175     


Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe Asn 
            180                 185                 190         


Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val Leu 
        195                 200                 205             


Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro Pro 
    210                 215                 220                 


Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu 
            260                 265                 270         


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445         


<210>  29
<211>  681
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  IgG1 Fc核酸序列

<400>  29
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  30
<211>  227
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  IgG1 Fc蛋白序列

<400>  30

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  31
<211>  681
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Knob mutant核酸序列

<400>  31
gacaaaactc acacatgccc accgtgccca gcacctgaac tcgagggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgtactg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  32
<211>  227
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Knob mutant蛋白序列

<400>  32

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  33
<211>  681
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hole mutant核酸序列

<400>  33
gacaaaactc acacatgccc accgtgccca gcacctgaac tcgagggggg accgtcagtc       60

ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca      120

tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac      180

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac      240

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag      300

tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa      360

gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag      420

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      480

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      540

gacggctcct tcttcctcac cagcaagctc accgtggaca agagcaggtg gcagcagggg      600

aacgtcttct catgctccgt gatgcacgag gctctgcaca accactacac gcagaagagc      660

ctctccctgt ctccgggtaa a                                                681


<210>  34
<211>  227
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  Hole mutant蛋白序列

<400>  34

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Glu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  35
<211>  2118
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD46-IgG1 Fc knob核酸序列

<400>  35
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

tgtgaggagc caccaacatt tgaagctatg gagctcattg gtaaaccaaa accctactat      420

gagattggtg aacgagtaga ttataagtgt aaaaaaggat acttctatat acctcctctt      480

gccacccata ctatttgtga tcggaatcat acatggctac ctgtctcaga tgacgcctgt      540

tatagagaaa catgtccata tatacgggat cctttaaatg gccaagcagt ccctgcaaat      600

gggacttacg agtttggtta tcagatgcac tttatttgta atgagggtta ttacttaatt      660

ggtgaagaaa ttctatattg tgaacttaaa ggatcagtag caatttggag cggtaagccc      720

ccaatatgtg aaaaggtttt gtgtacacca cctccaaaaa taaaaaatgg aaaacacacc      780

tttagtgaag tagaagtatt tgagtatctt gatgcagtaa cttatagttg tgatcctgca      840

cctggaccag atccattttc acttattgga gagagcacga tttattgtgg tgacaattca      900

gtgtggagtc gtgctgctcc agagtgtaaa gtggtcaaat gtcgatttcc agtagtcgaa      960

aatggaaaac agatatcagg atttggaaaa aaattttact acaaagcaac agttatgttt     1020

gaatgcgata agggttttta cctcgatggc agcgacacaa ttgtctgtga cagtaacagt     1080

acttgggatc ccccagttcc aaagtgtctt aaagtgctgc ctccatctag tacaaaacct     1140

ccagctttga gtcattcagt gtcgacttct tccactacaa aatctccagc gtccagtgcc     1200

tcaggtccta ggcctactta caagcctcca gtctcaaatt atccaggata tcctaaacct     1260

gaggaaggaa tacttgacag tttggatgtt tgggtcattg ctgtgattgt tattgccata     1320

gttgttggag ttgcagtaat ttgtgttgtc ccgtacagat atcttcaaag gaggaagaag     1380

aaaggcacat acctaactga tgagacccac agagaagtaa aatttacttc tctcgacaaa     1440

actcacacat gcccaccgtg cccagcacct gaactcgagg ggggaccgtc agtcttcctc     1500

ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacatgcgtg     1560

gtggtggacg tgagccacga agaccctgag gtcaagttca actggtacgt ggacggcgtg     1620

gaggtgcata atgccaagac aaagccgcgg gaggagcagt acaacagcac gtaccgtgtg     1680

gtcagcgtcc tcaccgtcct gcaccaggac tggctgaatg gcaaggagta caagtgcaag     1740

gtctccaaca aagccctccc agcccccatc gagaaaacca tctccaaagc caaagggcag     1800

ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag     1860

gtcagcctgt actgcctggt caaaggcttc tatcccagcg acatcgccgt ggagtgggag     1920

agcaatgggc agccggagaa caactacaag accacgcctc ccgtgctgga ctccgacggc     1980

tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc     2040

ttctcatgct ccgtgatgca cgaggctctg cacaaccact acacgcagaa gagcctctcc     2100

ctgtctccgg gtaaataa                                                   2118


<210>  36
<211>  705
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD46-IgG1 Fc knob蛋白序列

<400>  36

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Cys Glu Glu Pro Pro Thr Phe Glu 
        115                 120                 125             


Ala Met Glu Leu Ile Gly Lys Pro Lys Pro Tyr Tyr Glu Ile Gly Glu 
    130                 135                 140                 


Arg Val Asp Tyr Lys Cys Lys Lys Gly Tyr Phe Tyr Ile Pro Pro Leu 
145                 150                 155                 160 


Ala Thr His Thr Ile Cys Asp Arg Asn His Thr Trp Leu Pro Val Ser 
                165                 170                 175     


Asp Asp Ala Cys Tyr Arg Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu 
            180                 185                 190         


Asn Gly Gln Ala Val Pro Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln 
        195                 200                 205             


Met His Phe Ile Cys Asn Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile 
    210                 215                 220                 


Leu Tyr Cys Glu Leu Lys Gly Ser Val Ala Ile Trp Ser Gly Lys Pro 
225                 230                 235                 240 


Pro Ile Cys Glu Lys Val Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn 
                245                 250                 255     


Gly Lys His Thr Phe Ser Glu Val Glu Val Phe Glu Tyr Leu Asp Ala 
            260                 265                 270         


Val Thr Tyr Ser Cys Asp Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu 
        275                 280                 285             


Ile Gly Glu Ser Thr Ile Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg 
    290                 295                 300                 


Ala Ala Pro Glu Cys Lys Val Val Lys Cys Arg Phe Pro Val Val Glu 
305                 310                 315                 320 


Asn Gly Lys Gln Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala 
                325                 330                 335     


Thr Val Met Phe Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp 
            340                 345                 350         


Thr Ile Val Cys Asp Ser Asn Ser Thr Trp Asp Pro Pro Val Pro Lys 
        355                 360                 365             


Cys Leu Lys Val Leu Pro Pro Ser Ser Thr Lys Pro Pro Ala Leu Ser 
    370                 375                 380                 


His Ser Val Ser Thr Ser Ser Thr Thr Lys Ser Pro Ala Ser Ser Ala 
385                 390                 395                 400 


Ser Gly Pro Arg Pro Thr Tyr Lys Pro Pro Val Ser Asn Tyr Pro Gly 
                405                 410                 415     


Tyr Pro Lys Pro Glu Glu Gly Ile Leu Asp Ser Leu Asp Val Trp Val 
            420                 425                 430         


Ile Ala Val Ile Val Ile Ala Ile Val Val Gly Val Ala Val Ile Cys 
        435                 440                 445             


Val Val Pro Tyr Arg Tyr Leu Gln Arg Arg Lys Lys Lys Gly Thr Tyr 
    450                 455                 460                 


Leu Thr Asp Glu Thr His Arg Glu Val Lys Phe Thr Ser Leu Asp Lys 
465                 470                 475                 480 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Glu Gly Gly Pro 
                485                 490                 495     


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
            500                 505                 510         


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
        515                 520                 525             


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
    530                 535                 540                 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
545                 550                 555                 560 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
                565                 570                 575     


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
            580                 585                 590         


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
        595                 600                 605             


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Tyr 
    610                 615                 620                 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
625                 630                 635                 640 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
                645                 650                 655     


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
            660                 665                 670         


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
        675                 680                 685             


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    690                 695                 700                 


Lys 
705 


<210>  37
<211>  2085
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD55-IgG1 Fc knob核酸序列

<400>  37
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

gactgtggcc ttcccccaga tgtacctaat gcccagccag ctttggaagg ccgtacaagt      420

tttcccgagg atactgtaat aacgtacaaa tgtgaagaaa gctttgtgaa aattcctggc      480

gagaaggact cagtgatctg ccttaagggc agtcaatggt cagatattga agagttctgc      540

aatcgtagct gcgaggtgcc aacaaggcta aattctgcat ccctcaaaca gccttatatc      600

actcagaatt attttccagt cggtactgtt gtggaatatg agtgccgtcc aggttacaga      660

agagaacctt ctctatcacc aaaactaact tgccttcaga atttaaaatg gtccacagca      720

gtcgaatttt gtaaaaagaa atcatgccct aatccgggag aaatacgaaa tggtcagatt      780

gatgtaccag gtggcatatt atttggtgca accatctcct tctcatgtaa cacagggtac      840

aaattatttg gctcgacttc tagtttttgt cttatttcag gcagctctgt ccagtggagt      900

gacccgttgc cagagtgcag agaaatttat tgtccagcac caccacaaat tgacaatgga      960

ataattcaag gggaacgtga ccattatgga tatagacagt ctgtaacgta tgcatgtaat     1020

aaaggattca ccatgattgg agagcactct atttattgta ctgtgaataa tgatgaagga     1080

gagtggagtg gcccaccacc tgaatgcaga ggaaaatctc taacttccaa ggtcccacca     1140

acagttcaga aacctaccac agtaaatgtt ccaactacag aagtctcacc aacttctcag     1200

aaaaccacca caaaaaccac cacaccaaat gctcaagcaa cacggagtac acctgtttcc     1260

aggacaacca agcattttca tgaaacaacc ccaaataaag gaagtggaac cacttcaggt     1320

actacccgtc ttctatctgg gcacacgtgt ttcacgttga caggtttgct tgggacgcta     1380

gtaaccatgg gcttgctgac tgacaaaact cacacatgcc caccgtgccc agcacctgaa     1440

ctcgaggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc     1500

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc     1560

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag     1620

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg     1680

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1740

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1800

tcccgggagg agatgaccaa gaaccaggtc agcctgtact gcctggtcaa aggcttctat     1860

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1920

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1980

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcacga ggctctgcac     2040

aaccactaca cgcagaagag cctctccctg tctccgggta aataa                     2085


<210>  38
<211>  694
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD55-IgG1 Fc knob蛋白序列

<400>  38

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Asp Cys Gly Leu Pro Pro Asp Val 
        115                 120                 125             


Pro Asn Ala Gln Pro Ala Leu Glu Gly Arg Thr Ser Phe Pro Glu Asp 
    130                 135                 140                 


Thr Val Ile Thr Tyr Lys Cys Glu Glu Ser Phe Val Lys Ile Pro Gly 
145                 150                 155                 160 


Glu Lys Asp Ser Val Ile Cys Leu Lys Gly Ser Gln Trp Ser Asp Ile 
                165                 170                 175     


Glu Glu Phe Cys Asn Arg Ser Cys Glu Val Pro Thr Arg Leu Asn Ser 
            180                 185                 190         


Ala Ser Leu Lys Gln Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly 
        195                 200                 205             


Thr Val Val Glu Tyr Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser 
    210                 215                 220                 


Leu Ser Pro Lys Leu Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala 
225                 230                 235                 240 


Val Glu Phe Cys Lys Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg 
                245                 250                 255     


Asn Gly Gln Ile Asp Val Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile 
            260                 265                 270         


Ser Phe Ser Cys Asn Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser 
        275                 280                 285             


Phe Cys Leu Ile Ser Gly Ser Ser Val Gln Trp Ser Asp Pro Leu Pro 
    290                 295                 300                 


Glu Cys Arg Glu Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly 
305                 310                 315                 320 


Ile Ile Gln Gly Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr 
                325                 330                 335     


Tyr Ala Cys Asn Lys Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr 
            340                 345                 350         


Cys Thr Val Asn Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu 
        355                 360                 365             


Cys Arg Gly Lys Ser Leu Thr Ser Lys Val Pro Pro Thr Val Gln Lys 
    370                 375                 380                 


Pro Thr Thr Val Asn Val Pro Thr Thr Glu Val Ser Pro Thr Ser Gln 
385                 390                 395                 400 


Lys Thr Thr Thr Lys Thr Thr Thr Pro Asn Ala Gln Ala Thr Arg Ser 
                405                 410                 415     


Thr Pro Val Ser Arg Thr Thr Lys His Phe His Glu Thr Thr Pro Asn 
            420                 425                 430         


Lys Gly Ser Gly Thr Thr Ser Gly Thr Thr Arg Leu Leu Ser Gly His 
        435                 440                 445             


Thr Cys Phe Thr Leu Thr Gly Leu Leu Gly Thr Leu Val Thr Met Gly 
    450                 455                 460                 


Leu Leu Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
465                 470                 475                 480 


Leu Glu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                485                 490                 495     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            500                 505                 510         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        515                 520                 525             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    530                 535                 540                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
545                 550                 555                 560 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                565                 570                 575     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            580                 585                 590         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        595                 600                 605             


Gln Val Ser Leu Tyr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    610                 615                 620                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
625                 630                 635                 640 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                645                 650                 655     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            660                 665                 670         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        675                 680                 685             


Ser Leu Ser Pro Gly Lys 
    690                 


<210>  39
<211>  1959
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH-IgG1 Fc hole核酸序列

<400>  39
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct      420

gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      480

cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      540

aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      600

acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      660

caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      720

cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      780

agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      840

aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      900

agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      960

tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac     1020

atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg     1080

ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca     1140

cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt     1200

tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg     1260

agatgtacct tgaaagacaa aactcacaca tgcccaccgt gcccagcacc tgaactcgag     1320

gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg     1380

acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc     1440

aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag     1500

tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat     1560

ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc     1620

atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg     1680

gaggagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc     1740

gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct     1800

cccgtgctgg actccgacgg ctccttcttc ctcaccagca agctcaccgt ggacaagagc     1860

aggtggcagc aggggaacgt cttctcatgc tccgtgatgc acgaggctct gcacaaccac     1920

tacacgcaga agagcctctc cctgtctccg ggtaaataa                            1959


<210>  40
<211>  652
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH-IgG1 Fc hole蛋白序列

<400>  40

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Glu Asp Cys Asn Glu Leu Pro Pro 
        115                 120                 125             


Arg Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr 
    130                 135                 140                 


Pro Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser 
145                 150                 155                 160 


Leu Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu 
                165                 170                 175     


Asn Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp 
            180                 185                 190         


Thr Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr 
        195                 200                 205             


Gly Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly 
    210                 215                 220                 


Glu Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile 
225                 230                 235                 240 


Pro Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn 
                245                 250                 255     


Gly Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe 
            260                 265                 270         


Gly Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly 
        275                 280                 285             


Asp Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys 
    290                 295                 300                 


Pro Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly 
305                 310                 315                 320 


Ser Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln 
                325                 330                 335     


Tyr Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val 
            340                 345                 350         


Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser 
        355                 360                 365             


Cys Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile 
    370                 375                 380                 


Lys His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe 
385                 390                 395                 400 


Tyr Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp 
                405                 410                 415     


Ile Pro Ala Pro Arg Cys Thr Leu Lys Asp Lys Thr His Thr Cys Pro 
            420                 425                 430         


Pro Cys Pro Ala Pro Glu Leu Glu Gly Gly Pro Ser Val Phe Leu Phe 
        435                 440                 445             


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    450                 455                 460                 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
465                 470                 475                 480 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                485                 490                 495     


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            500                 505                 510         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        515                 520                 525             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    530                 535                 540                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
545                 550                 555                 560 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                565                 570                 575     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            580                 585                 590         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        595                 600                 605             


Phe Phe Leu Thr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    610                 615                 620                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
625                 630                 635                 640 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                645                 650         


<210>  41
<211>  1353
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD59-IgG1 Fc hole核酸序列

<400>  41
atgggccgtc ccatcctgga agtgccagag agtgtaacag gaccttggaa aggggatgtg       60

aatcttccct gcacctatga ccccctgcaa ggctacaccc aagtcttggt gaagtggctg      120

gtacaacgtg gctcagaccc tgtcaccatc tttctacgtg actcttctgg agaccatatc      180

cagcaggcaa agtaccaggg ccgcctgcat gtgagccaca aggttccagg agatgtatcc      240

ctccaattga gcaccctgga gatggatgac cggagccact acacgtgtga agtcacctgg      300

cagactcctg atggcaacca agtcgtgaga gataagatta ctgagctccg tgtccagaaa      360

ctgcagtgct acaactgtcc taacccaact gctgactgca aaacagccgt caattgttca      420

tctgattttg atgcgtgtct cattaccaaa gctgggttac aagtgtataa caagtgttgg      480

aagtttgagc attgcaattt caacgacgtc acaacccgct tgagggaaaa tgagctaacg      540

tactactgct gcaagaagga cctgtgtaac tttaacgaac agcttgaaaa tggtgggaca      600

tccttatcag agaaaacagt tcttctgctg gtgactccat ttctggcagc agcctggagc      660

cttcatcccg acaaaactca cacatgccca ccgtgcccag cacctgaact cgagggggga      720

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct      780

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      840

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      900

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      960

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1020

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggaggag     1080

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1140

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1200

ctggactccg acggctcctt cttcctcacc agcaagctca ccgtggacaa gagcaggtgg     1260

cagcagggga acgtcttctc atgctccgtg atgcacgagg ctctgcacaa ccactacacg     1320

cagaagagcc tctccctgtc tccgggtaaa taa                                  1353


<210>  42
<211>  450
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CD59-IgG1 Fc hole蛋白序列

<400>  42

Met Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
1               5                   10                  15      


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
            20                  25                  30          


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
        35                  40                  45              


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
    50                  55                  60                  


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
65                  70                  75                  80  


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
            100                 105                 110         


Ile Thr Glu Leu Arg Val Gln Lys Leu Gln Cys Tyr Asn Cys Pro Asn 
        115                 120                 125             


Pro Thr Ala Asp Cys Lys Thr Ala Val Asn Cys Ser Ser Asp Phe Asp 
    130                 135                 140                 


Ala Cys Leu Ile Thr Lys Ala Gly Leu Gln Val Tyr Asn Lys Cys Trp 
145                 150                 155                 160 


Lys Phe Glu His Cys Asn Phe Asn Asp Val Thr Thr Arg Leu Arg Glu 
                165                 170                 175     


Asn Glu Leu Thr Tyr Tyr Cys Cys Lys Lys Asp Leu Cys Asn Phe Asn 
            180                 185                 190         


Glu Gln Leu Glu Asn Gly Gly Thr Ser Leu Ser Glu Lys Thr Val Leu 
        195                 200                 205             


Leu Leu Val Thr Pro Phe Leu Ala Ala Ala Trp Ser Leu His Pro Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Glu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Thr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  43
<211>  45
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子1核酸序列

<400>  43
ggcggaggtg gatctggcgg aggtggatct ggcggaggtg gatct                       45


<210>  44
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子1蛋白序列

<400>  44

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  45
<211>  24
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子2核酸序列

<400>  45
ggcggaggtg gaggcggagg tgga                                              24


<210>  46
<211>  8
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子2蛋白序列

<400>  46

Gly Gly Gly Gly Gly Gly Gly Gly 
1               5               


<210>  47
<211>  45
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子3核酸序列

<400>  47
gaagctgccg caaaggaagc tgccgcaaag gaagctgccg caaag                       45


<210>  48
<211>  15
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子3蛋白序列

<400>  48

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  49
<211>  51
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子4核酸序列

<400>  49
gttagtcaaa cttctaaatt aactcgtgcc gagacagttt tccctgatgt t                51


<210>  50
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  连接子4蛋白序列

<400>  50

Val Ser Gln Thr Ser Lys Leu Thr Arg Ala Glu Thr Val Phe Pro Asp 
1               5                   10                  15      


Val 


<210>  51
<211>  1272
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH的核酸序列

<400>  51
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat       60

cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta      120

caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag      180

caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc      240

caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag      300

actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaagaa      360

gattgcaatg aacttcctcc aagaagaaat acagaaattc tgacaggttc ctggtctgac      420

caaacatatc cagaaggcac ccaggctatc tataaatgcc gccctggata tagatctctt      480

ggaaatgtaa taatggtatg caggaaggga gaatgggttg ctcttaatcc attaaggaaa      540

tgtcagaaaa ggccctgtgg acatcctgga gatactcctt ttggtacttt tacccttaca      600

ggaggaaatg tgtttgaata tggtgtaaaa gctgtgtata catgtaatga ggggtatcaa      660

ttgctaggtg agattaatta ccgtgaatgt gacacagatg gatggaccaa tgatattcct      720

atatgtgaag ttgtgaagtg tttaccagtg acagcaccag agaatggaaa aattgtcagt      780

agtgcaatgg aaccagatcg ggaataccat tttggacaag cagtacggtt tgtatgtaac      840

tcaggctaca agattgaagg agatgaagaa atgcattgtt cagacgatgg tttttggagt      900

aaagagaaac caaagtgtgt ggaaatttca tgcaaatccc cagatgttat aaatggatct      960

cctatatctc agaagattat ttataaggag aatgaacgat ttcaatataa atgtaacatg     1020

ggttatgaat acagtgaaag aggagatgct gtatgcactg aatctggatg gcgtccgttg     1080

ccttcatgtg aagaaaaatc atgtgataat ccttatattc caaatggtga ctactcacct     1140

ttaaggatta aacacagaac tggagatgaa atcacgtacc agtgtagaaa tggtttttat     1200

cctgcaaccc ggggaaatac agcaaaatgc acaagtactg gctggatacc tgctccgaga     1260

tgtaccttga aa                                                         1272


<210>  52
<211>  424
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-FH的蛋白序列

<400>  52

Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      


Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          


Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              


Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  


Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         


Thr Glu Leu Arg Val Gln Lys Glu Asp Cys Asn Glu Leu Pro Pro Arg 
        115                 120                 125             


Arg Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro 
    130                 135                 140                 


Glu Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu 
145                 150                 155                 160 


Gly Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn 
                165                 170                 175     


Pro Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr 
            180                 185                 190         


Pro Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly 
        195                 200                 205             


Val Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu 
    210                 215                 220                 


Ile Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro 
225                 230                 235                 240 


Ile Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly 
                245                 250                 255     


Lys Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly 
            260                 265                 270         


Gln Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp 
        275                 280                 285             


Glu Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro 
    290                 295                 300                 


Lys Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser 
305                 310                 315                 320 


Pro Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr 
                325                 330                 335     


Lys Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys 
            340                 345                 350         


Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys 
        355                 360                 365             


Asp Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys 
    370                 375                 380                 


His Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr 
385                 390                 395                 400 


Pro Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile 
                405                 410                 415     


Pro Ala Pro Arg Cys Thr Leu Lys 
            420                 


<210>  53
<211>  1032
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-IgG4 Fc核酸序列

<400>  53
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat       60

cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta      120

caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag      180

caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc      240

caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag      300

actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaaccc      360

ccatgcccat catgcccagc acctgagttc ctggggggac catcagtctt cctgttcccc      420

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg      480

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg      540

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc      600

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc      660

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga      720

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc      780

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat      840

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc      900

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca      960

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1020

ctgggtaaat aa                                                         1032


<210>  54
<211>  343
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-IgG4 Fc蛋白序列

<400>  54

Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      


Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          


Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              


Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  


Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         


Thr Glu Leu Arg Val Gln Lys Pro Pro Cys Pro Ser Cys Pro Ala Pro 
        115                 120                 125             


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    130                 135                 140                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
145                 150                 155                 160 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
                165                 170                 175     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
            180                 185                 190         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        195                 200                 205             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
    210                 215                 220                 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
225                 230                 235                 240 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
                245                 250                 255     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            260                 265                 270         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        275                 280                 285             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    290                 295                 300                 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
305                 310                 315                 320 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                325                 330                 335     


Leu Ser Leu Ser Leu Gly Lys 
            340             


<210>  55
<211>  1590
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  FH-IgG4 Fc 核酸序列

<400>  55
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct       60

gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      120

cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      180

aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      240

acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      300

caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      360

cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      420

agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      480

aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      540

agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      600

tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac      660

atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg      720

ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca      780

cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt      840

tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg      900

agatgtacct tgaaaccccc atgcccatca tgcccagcac ctgagttcct ggggggacca      960

tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag     1020

gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac     1080

gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc     1140

acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag     1200

tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa     1260

gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg     1320

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc     1380

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1440

gactccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag     1500

gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag     1560

aagagcctct ccctgtctct gggtaaataa                                      1590


<210>  56
<211>  529
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  FH-IgG4 Fc蛋白序列

<400>  56

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
305                 310                 315                 320 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                325                 330                 335     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            340                 345                 350         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        355                 360                 365             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    370                 375                 380                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
385                 390                 395                 400 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                405                 410                 415     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            420                 425                 430         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        435                 440                 445             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    450                 455                 460                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
465                 470                 475                 480 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                485                 490                 495     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            500                 505                 510         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        515                 520                 525             


Lys 
    


<210>  57
<211>  1947
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  FH-CRIg-IgG4 Fc 核酸序列

<400>  57
gaagattgca atgaacttcc tccaagaaga aatacagaaa ttctgacagg ttcctggtct       60

gaccaaacat atccagaagg cacccaggct atctataaat gccgccctgg atatagatct      120

cttggaaatg taataatggt atgcaggaag ggagaatggg ttgctcttaa tccattaagg      180

aaatgtcaga aaaggccctg tggacatcct ggagatactc cttttggtac ttttaccctt      240

acaggaggaa atgtgtttga atatggtgta aaagctgtgt atacatgtaa tgaggggtat      300

caattgctag gtgagattaa ttaccgtgaa tgtgacacag atggatggac caatgatatt      360

cctatatgtg aagttgtgaa gtgtttacca gtgacagcac cagagaatgg aaaaattgtc      420

agtagtgcaa tggaaccaga tcgggaatac cattttggac aagcagtacg gtttgtatgt      480

aactcaggct acaagattga aggagatgaa gaaatgcatt gttcagacga tggtttttgg      540

agtaaagaga aaccaaagtg tgtggaaatt tcatgcaaat ccccagatgt tataaatgga      600

tctcctatat ctcagaagat tatttataag gagaatgaac gatttcaata taaatgtaac      660

atgggttatg aatacagtga aagaggagat gctgtatgca ctgaatctgg atggcgtccg      720

ttgccttcat gtgaagaaaa atcatgtgat aatccttata ttccaaatgg tgactactca      780

cctttaagga ttaaacacag aactggagat gaaatcacgt accagtgtag aaatggtttt      840

tatcctgcaa cccggggaaa tacagcaaaa tgcacaagta ctggctggat acctgctccg      900

agatgtacct tgaaaggccg tcccatcctg gaagtgccag agagtgtaac aggaccttgg      960

aaaggggatg tgaatcttcc ctgcacctat gaccccctgc aaggctacac ccaagtcttg     1020

gtgaagtggc tggtacaacg tggctcagac cctgtcacca tctttctacg tgactcttct     1080

ggagaccata tccagcaggc aaagtaccag ggccgcctgc atgtgagcca caaggttcca     1140

ggagatgtat ccctccaatt gagcaccctg gagatggatg accggagcca ctacacgtgt     1200

gaagtcacct ggcagactcc tgatggcaac caagtcgtga gagataagat tactgagctc     1260

cgtgtccaga aacccccatg cccatcatgc ccagcacctg agttcctggg gggaccatca     1320

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc     1380

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg     1440

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg     1500

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1560

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1620

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1680

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1740

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1800

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1860

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1920

agcctctccc tgtctctggg taaataa                                         1947


<210>  58
<211>  648
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  FH-CRIg-IgG4 Fc蛋白序列

<400>  58

Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu Thr 
1               5                   10                  15      


Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile Tyr 
            20                  25                  30          


Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val Cys 
        35                  40                  45              


Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln Lys 
    50                  55                  60                  


Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr Leu 
65                  70                  75                  80  


Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr Cys 
                85                  90                  95      


Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys Asp 
            100                 105                 110         


Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys Cys 
        115                 120                 125             


Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala Met 
    130                 135                 140                 


Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val Cys 
145                 150                 155                 160 


Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser Asp 
                165                 170                 175     


Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser Cys 
            180                 185                 190         


Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile Ile 
        195                 200                 205             


Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr Glu 
    210                 215                 220                 


Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro 
225                 230                 235                 240 


Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile Pro Asn 
                245                 250                 255     


Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp Glu Ile 
            260                 265                 270         


Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly Asn Thr 
        275                 280                 285             


Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys Thr Leu 
    290                 295                 300                 


Lys Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp 
305                 310                 315                 320 


Lys Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr 
                325                 330                 335     


Thr Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val 
            340                 345                 350         


Thr Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys 
        355                 360                 365             


Tyr Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser 
    370                 375                 380                 


Leu Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys 
385                 390                 395                 400 


Glu Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys 
                405                 410                 415     


Ile Thr Glu Leu Arg Val Gln Lys Pro Pro Cys Pro Ser Cys Pro Ala 
            420                 425                 430         


Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        435                 440                 445             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    450                 455                 460                 


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
465                 470                 475                 480 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                485                 490                 495     


Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            500                 505                 510         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
        515                 520                 525             


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    530                 535                 540                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
545                 550                 555                 560 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                565                 570                 575     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            580                 585                 590         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        595                 600                 605             


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
    610                 615                 620                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
625                 630                 635                 640 


Ser Leu Ser Leu Ser Leu Gly Lys 
                645             


<210>  59
<211>  1992
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-L-FH-IgG4 Fc 核酸序列

<400>  59
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat       60

cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta      120

caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag      180

caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc      240

caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag      300

actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaaggc      360

ggaggtggat ctggcggagg tggatctggc ggaggtggat ctgaagattg caatgaactt      420

cctccaagaa gaaatacaga aattctgaca ggttcctggt ctgaccaaac atatccagaa      480

ggcacccagg ctatctataa atgccgccct ggatatagat ctcttggaaa tgtaataatg      540

gtatgcagga agggagaatg ggttgctctt aatccattaa ggaaatgtca gaaaaggccc      600

tgtggacatc ctggagatac tccttttggt acttttaccc ttacaggagg aaatgtgttt      660

gaatatggtg taaaagctgt gtatacatgt aatgaggggt atcaattgct aggtgagatt      720

aattaccgtg aatgtgacac agatggatgg accaatgata ttcctatatg tgaagttgtg      780

aagtgtttac cagtgacagc accagagaat ggaaaaattg tcagtagtgc aatggaacca      840

gatcgggaat accattttgg acaagcagta cggtttgtat gtaactcagg ctacaagatt      900

gaaggagatg aagaaatgca ttgttcagac gatggttttt ggagtaaaga gaaaccaaag      960

tgtgtggaaa tttcatgcaa atccccagat gttataaatg gatctcctat atctcagaag     1020

attatttata aggagaatga acgatttcaa tataaatgta acatgggtta tgaatacagt     1080

gaaagaggag atgctgtatg cactgaatct ggatggcgtc cgttgccttc atgtgaagaa     1140

aaatcatgtg ataatcctta tattccaaat ggtgactact cacctttaag gattaaacac     1200

agaactggag atgaaatcac gtaccagtgt agaaatggtt tttatcctgc aacccgggga     1260

aatacagcaa aatgcacaag tactggctgg atacctgctc cgagatgtac cttgaaaccc     1320

ccatgcccat catgcccagc acctgagttc ctggggggac catcagtctt cctgttcccc     1380

ccaaaaccca aggacactct catgatctcc cggacccctg aggtcacgtg cgtggtggtg     1440

gacgtgagcc aggaagaccc cgaggtccag ttcaactggt acgtggatgg cgtggaggtg     1500

cataatgcca agacaaagcc gcgggaggag cagttcaaca gcacgtaccg tgtggtcagc     1560

gtcctcaccg tcctgcacca ggactggctg aacggcaagg agtacaagtg caaggtctcc     1620

aacaaaggcc tcccgtcctc catcgagaaa accatctcca aagccaaagg gcagccccga     1680

gagccacagg tgtacaccct gcccccatcc caggaggaga tgaccaagaa ccaggtcagc     1740

ctgacctgcc tggtcaaagg cttctacccc agcgacatcg ccgtggagtg ggagagcaat     1800

gggcagccgg agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc     1860

ttcctctaca gcaggctaac cgtggacaag agcaggtggc aggaggggaa tgtcttctca     1920

tgctccgtga tgcatgaggc tctgcacaac cactacacac agaagagcct ctccctgtct     1980

ctgggtaaat aa                                                         1992


<210>  60
<211>  663
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-L-FH-IgG4 Fc蛋白序列

<400>  60

Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      


Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          


Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              


Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  


Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         


Thr Glu Leu Arg Val Gln Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg 
    130                 135                 140                 


Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu 
145                 150                 155                 160 


Gly Thr Gln Ala Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly 
                165                 170                 175     


Asn Val Ile Met Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro 
            180                 185                 190         


Leu Arg Lys Cys Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro 
        195                 200                 205             


Phe Gly Thr Phe Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val 
    210                 215                 220                 


Lys Ala Val Tyr Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile 
225                 230                 235                 240 


Asn Tyr Arg Glu Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile 
                245                 250                 255     


Cys Glu Val Val Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys 
            260                 265                 270         


Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln 
        275                 280                 285             


Ala Val Arg Phe Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu 
    290                 295                 300                 


Glu Met His Cys Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys 
305                 310                 315                 320 


Cys Val Glu Ile Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro 
                325                 330                 335     


Ile Ser Gln Lys Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys 
            340                 345                 350         


Cys Asn Met Gly Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr 
        355                 360                 365             


Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp 
    370                 375                 380                 


Asn Pro Tyr Ile Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His 
385                 390                 395                 400 


Arg Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro 
                405                 410                 415     


Ala Thr Arg Gly Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro 
            420                 425                 430         


Ala Pro Arg Cys Thr Leu Lys Pro Pro Cys Pro Ser Cys Pro Ala Pro 
        435                 440                 445             


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    450                 455                 460                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
465                 470                 475                 480 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
                485                 490                 495     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
            500                 505                 510         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        515                 520                 525             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
    530                 535                 540                 


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
545                 550                 555                 560 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
                565                 570                 575     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            580                 585                 590         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        595                 600                 605             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    610                 615                 620                 


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
625                 630                 635                 640 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                645                 650                 655     


Leu Ser Leu Ser Leu Gly Lys 
            660        


<210>  61
<211>  762
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CR1 CCP8-11的核酸序列

<400>  61
gatcattttc tgtttgccaa gttgaaaacc caaaccaatg catctgactt tcccattggg       60

acatctttaa agtacgaatg ccgtcctgag tactacggga ggccattctc tatcacatgt      120

ctagataacc tggtctggtc aagtcccaaa gatgtctgta aacgtaaatc atgtaaaact      180

cctccagatc cagtgaatgg catggtgcat gtgatcacag acatccaggt tggatccaga      240

atcaactatt cttgtactac agggcaccga ctcattggtc actcatctgc tgaatgtatc      300

ctctcgggca atgctgccca ttggagcacg aagccgccaa tttgtcaacg aattccttgt      360

gggctacccc ccaccatcgc caatggagat ttcattagca ccaacagaga gaattttcac      420

tatggatcag tggtgaccta ccgctgcaat cctggaagcg gagggagaaa ggtgtttgag      480

cttgtgggtg agccctccat atactgcacc agcaatgacg atcaagtggg catctggagc      540

ggcccggccc ctcagtgcat tatacctaac aaatgcacgc ctccaaatgt ggaaaatgga      600

atattggtat ctgacaacag aagcttattt tccttaaatg aagttgtgga gtttaggtgt      660

cagcctggct ttgtcatgaa aggaccccgc cgtgtgaagt gccaggccct gaacaaatgg      720

gagccggagc taccaagctg ctccagggta tgtcagccac ct                         762


<210>  62
<211>  254
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CR1 CCP8-11的蛋白序列

<400>  62

Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
1               5                   10                  15      


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
            20                  25                  30          


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
        35                  40                  45              


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
    50                  55                  60                  


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
65                  70                  75                  80  


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
                85                  90                  95      


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
            100                 105                 110         


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
        115                 120                 125             


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
    130                 135                 140                 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
145                 150                 155                 160 


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
                165                 170                 175     


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
            180                 185                 190         


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
        195                 200                 205             


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
    210                 215                 220                 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
225                 230                 235                 240 


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro 
                245                 250                 


<210>  63
<211>  762
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CR1 CCP15-18的核酸序列

<400>  63
gatcattttc tgtttgccaa gttgaaaacc caaaccaatg catctgactt tcccattggg       60

acatctttaa agtacgaatg ccgtcctgag tactacggga ggccattctc tatcacatgt      120

ctagataacc tggtctggtc aagtcccaaa gatgtctgta aacgtaaatc atgtaaaact      180

cctccagatc cagtgaatgg catggtgcat gtgatcacag acatccaggt tggatccaga      240

atcaactatt cttgtactac agggcaccga ctcattggtc actcatctgc tgaatgtatc      300

ctctcaggca atactgccca ttggagcacg aagccgccaa tttgtcaacg aattccttgt      360

gggctacccc caaccatcgc caatggagat ttcattagca ccaacagaga gaattttcac      420

tatggatcag tggtgaccta ccgctgcaat cttggaagca gagggagaaa ggtgtttgag      480

cttgtgggtg agccctccat atactgcacc agcaatgacg atcaagtggg catctggagc      540

ggccccgccc ctcagtgcat tatacctaac aaatgcacgc ctccaaatgt ggaaaatgga      600

atattggtat ctgacaacag aagcttattt tccttaaatg aagttgtgga gtttaggtgt      660

cagcctggct ttgtcatgaa aggaccccgc cgtgtgaagt gccaggccct gaacaaatgg      720

gagccagagt taccaagctg ctccagggtg tgtcagccgc ct                         762


<210>  64
<211>  254
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CR1 CCP15-18的蛋白序列

<400>  64

Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
1               5                   10                  15      


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
            20                  25                  30          


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
        35                  40                  45              


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
    50                  55                  60                  


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
65                  70                  75                  80  


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
                85                  90                  95      


Ala Glu Cys Ile Leu Ser Gly Asn Thr Ala His Trp Ser Thr Lys Pro 
            100                 105                 110         


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
        115                 120                 125             


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
    130                 135                 140                 


Val Thr Tyr Arg Cys Asn Leu Gly Ser Arg Gly Arg Lys Val Phe Glu 
145                 150                 155                 160 


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
                165                 170                 175     


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
            180                 185                 190         


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
        195                 200                 205             


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
    210                 215                 220                 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
225                 230                 235                 240 


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro 
                245                 250                 


<210>  65
<211>  1794
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CR1(CCP8-11)-IgG4 Fc核酸序列

<400>  65
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat       60

cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta      120

caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag      180

caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc      240

caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag      300

actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaagat      360

cattttctgt ttgccaagtt gaaaacccaa accaatgcat ctgactttcc cattgggaca      420

tctttaaagt acgaatgccg tcctgagtac tacgggaggc cattctctat cacatgtcta      480

gataacctgg tctggtcaag tcccaaagat gtctgtaaac gtaaatcatg taaaactcct      540

ccagatccag tgaatggcat ggtgcatgtg atcacagaca tccaggttgg atccagaatc      600

aactattctt gtactacagg gcaccgactc attggtcact catctgctga atgtatcctc      660

tcgggcaatg ctgcccattg gagcacgaag ccgccaattt gtcaacgaat tccttgtggg      720

ctacccccca ccatcgccaa tggagatttc attagcacca acagagagaa ttttcactat      780

ggatcagtgg tgacctaccg ctgcaatcct ggaagcggag ggagaaaggt gtttgagctt      840

gtgggtgagc cctccatata ctgcaccagc aatgacgatc aagtgggcat ctggagcggc      900

ccggcccctc agtgcattat acctaacaaa tgcacgcctc caaatgtgga aaatggaata      960

ttggtatctg acaacagaag cttattttcc ttaaatgaag ttgtggagtt taggtgtcag     1020

cctggctttg tcatgaaagg accccgccgt gtgaagtgcc aggccctgaa caaatgggag     1080

ccggagctac caagctgctc cagggtatgt cagccacctc ccccatgccc atcatgccca     1140

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact     1200

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac     1260

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag     1320

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1380

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1440

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1500

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1560

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1620

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1680

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1740

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa ataa           1794


<210>  66
<211>  597
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CR1(CCP8-11)-IgG4 Fc蛋白序列

<400>  66

Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      


Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          


Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              


Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  


Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         


Thr Glu Leu Arg Val Gln Lys Asp His Phe Leu Phe Ala Lys Leu Lys 
        115                 120                 125             


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
    130                 135                 140                 


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
145                 150                 155                 160 


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
                165                 170                 175     


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
            180                 185                 190         


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
        195                 200                 205             


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala 
    210                 215                 220                 


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
225                 230                 235                 240 


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
                245                 250                 255     


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser 
            260                 265                 270         


Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
        275                 280                 285             


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
    290                 295                 300                 


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
305                 310                 315                 320 


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
                325                 330                 335     


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
            340                 345                 350         


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
        355                 360                 365             


Val Cys Gln Pro Pro Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
    370                 375                 380                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
385                 390                 395                 400 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                405                 410                 415     


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            420                 425                 430         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        435                 440                 445             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    450                 455                 460                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
465                 470                 475                 480 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                485                 490                 495     


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
            500                 505                 510         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        515                 520                 525             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    530                 535                 540                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
545                 550                 555                 560 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
                565                 570                 575     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            580                 585                 590         


Leu Ser Leu Gly Lys 
        595         


<210>  67
<211>  1794
<212>  DNA
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CR1(CCP15-18)-IgG4 Fc核酸序列

<400>  67
ggccgtccca tcctggaagt gccagagagt gtaacaggac cttggaaagg ggatgtgaat       60

cttccctgca cctatgaccc cctgcaaggc tacacccaag tcttggtgaa gtggctggta      120

caacgtggct cagaccctgt caccatcttt ctacgtgact cttctggaga ccatatccag      180

caggcaaagt accagggccg cctgcatgtg agccacaagg ttccaggaga tgtatccctc      240

caattgagca ccctggagat ggatgaccgg agccactaca cgtgtgaagt cacctggcag      300

actcctgatg gcaaccaagt cgtgagagat aagattactg agctccgtgt ccagaaagat      360

cattttctgt ttgccaagtt gaaaacccaa accaatgcat ctgactttcc cattgggaca      420

tctttaaagt acgaatgccg tcctgagtac tacgggaggc cattctctat cacatgtcta      480

gataacctgg tctggtcaag tcccaaagat gtctgtaaac gtaaatcatg taaaactcct      540

ccagatccag tgaatggcat ggtgcatgtg atcacagaca tccaggttgg atccagaatc      600

aactattctt gtactacagg gcaccgactc attggtcact catctgctga atgtatcctc      660

tcaggcaata ctgcccattg gagcacgaag ccgccaattt gtcaacgaat tccttgtggg      720

ctacccccaa ccatcgccaa tggagatttc attagcacca acagagagaa ttttcactat      780

ggatcagtgg tgacctaccg ctgcaatctt ggaagcagag ggagaaaggt gtttgagctt      840

gtgggtgagc cctccatata ctgcaccagc aatgacgatc aagtgggcat ctggagcggc      900

cccgcccctc agtgcattat acctaacaaa tgcacgcctc caaatgtgga aaatggaata      960

ttggtatctg acaacagaag cttattttcc ttaaatgaag ttgtggagtt taggtgtcag     1020

cctggctttg tcatgaaagg accccgccgt gtgaagtgcc aggccctgaa caaatgggag     1080

ccagagttac caagctgctc cagggtgtgt cagccgcctc ccccatgccc atcatgccca     1140

gcacctgagt tcctgggggg accatcagtc ttcctgttcc ccccaaaacc caaggacact     1200

ctcatgatct cccggacccc tgaggtcacg tgcgtggtgg tggacgtgag ccaggaagac     1260

cccgaggtcc agttcaactg gtacgtggat ggcgtggagg tgcataatgc caagacaaag     1320

ccgcgggagg agcagttcaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac     1380

caggactggc tgaacggcaa ggagtacaag tgcaaggtct ccaacaaagg cctcccgtcc     1440

tccatcgaga aaaccatctc caaagccaaa gggcagcccc gagagccaca ggtgtacacc     1500

ctgcccccat cccaggagga gatgaccaag aaccaggtca gcctgacctg cctggtcaaa     1560

ggcttctacc ccagcgacat cgccgtggag tgggagagca atgggcagcc ggagaacaac     1620

tacaagacca cgcctcccgt gctggactcc gacggctcct tcttcctcta cagcaggcta     1680

accgtggaca agagcaggtg gcaggagggg aatgtcttct catgctccgt gatgcatgag     1740

gctctgcaca accactacac acagaagagc ctctccctgt ctctgggtaa ataa           1794


<210>  68
<211>  597
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  CRIg-CR1(CCP15-18)-IgG4 Fc蛋白序列

<400>  68

Gly Arg Pro Ile Leu Glu Val Pro Glu Ser Val Thr Gly Pro Trp Lys 
1               5                   10                  15      


Gly Asp Val Asn Leu Pro Cys Thr Tyr Asp Pro Leu Gln Gly Tyr Thr 
            20                  25                  30          


Gln Val Leu Val Lys Trp Leu Val Gln Arg Gly Ser Asp Pro Val Thr 
        35                  40                  45              


Ile Phe Leu Arg Asp Ser Ser Gly Asp His Ile Gln Gln Ala Lys Tyr 
    50                  55                  60                  


Gln Gly Arg Leu His Val Ser His Lys Val Pro Gly Asp Val Ser Leu 
65                  70                  75                  80  


Gln Leu Ser Thr Leu Glu Met Asp Asp Arg Ser His Tyr Thr Cys Glu 
                85                  90                  95      


Val Thr Trp Gln Thr Pro Asp Gly Asn Gln Val Val Arg Asp Lys Ile 
            100                 105                 110         


Thr Glu Leu Arg Val Gln Lys Asp His Phe Leu Phe Ala Lys Leu Lys 
        115                 120                 125             


Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr 
    130                 135                 140                 


Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu 
145                 150                 155                 160 


Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser 
                165                 170                 175     


Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr 
            180                 185                 190         


Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His 
        195                 200                 205             


Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Thr 
    210                 215                 220                 


Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly 
225                 230                 235                 240 


Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu 
                245                 250                 255     


Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Leu Gly Ser 
            260                 265                 270         


Arg Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys 
        275                 280                 285             


Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln 
    290                 295                 300                 


Cys Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile 
305                 310                 315                 320 


Leu Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu 
                325                 330                 335     


Phe Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys 
            340                 345                 350         


Cys Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg 
        355                 360                 365             


Val Cys Gln Pro Pro Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
    370                 375                 380                 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
385                 390                 395                 400 


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
                405                 410                 415     


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
            420                 425                 430         


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
        435                 440                 445             


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
    450                 455                 460                 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
465                 470                 475                 480 


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
                485                 490                 495     


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
            500                 505                 510         


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
        515                 520                 525             


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
    530                 535                 540                 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
545                 550                 555                 560 


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
                565                 570                 575     


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
            580                 585                 590         


Leu Ser Leu Gly Lys 
        595         


