﻿                         序列表

<110>  天津药物研究院有限公司

<120>  具有双受体激动作用的多肽衍生物及其用途

<130>  EIC21310009P

<150>  2020103882080
<151>  2020-5-9

<160>  27

<170>  SIPOSequenceListing 1.0

<210>  1
<211>  30
<212>  PRT
<213>  GLP-1

<400>  1
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  

<210>  2
<211>  29
<212>  PRT
<213>  Glucagon

<400>  2
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  

<210>  3
<211>  37
<212>  PRT
<213>  Oxintomodulin(Glucagon)

<400>  3
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      
Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          
Arg Asn Asn Ile Ala 
        35          

<210>  4
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  4
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  

<210>  5
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  丝氨酸为D-Ser


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  5
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  

<210>  6
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  丝氨酸为D-Ser


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  6
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  

<210>  7
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  7
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  

<210>  8
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  8
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  

<210>  9
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  9
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Val Ala Trp Leu Glu Ala Gly Gly 
            20                  25                  30  

<210>  10
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  10
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ser Gly Gly 
            20                  25                  30  

<210>  11
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  丝氨酸为D-Ser


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  11
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Val Ala Trp Leu Glu Ser Gly Gly 
            20                  25                  30  

<210>  12
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  12
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ser Gly Gly 
            20                  25                  30  

<210>  13
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  13
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ser Gly Gly 
            20                  25                  30  

<210>  14
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  14
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Val Ala Trp Leu Glu Ser Gly Gly 
            20                  25                  30  

<210>  15
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  15
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Ser Gly Gly 
            20                  25                  30  

<210>  16
<211>  29
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  16
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Gly 
            20                  25                  

<210>  17
<211>  29
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  丝氨酸为D-Ser


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  17
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Val Ala Trp Leu Glu Gly Gly 
            20                  25                  

<210>  18
<211>  29
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  18
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Gly 
            20                  25                  

<210>  19
<211>  29
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  19
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Gly 
            20                  25                  

<210>  20
<211>  29
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  20
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Val Ala Trp Leu Glu Gly Gly 
            20                  25                  

<210>  21
<211>  29
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  21
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Gly 
            20                  25                  

<210>  22
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  22
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Glu Gly 
            20                  25                  30  

<210>  23
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  丝氨酸为D-Ser


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  23
His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Val Ala Trp Leu Glu Gly Glu Gly 
            20                  25                  30  

<210>  24
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  24
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Glu Gly 
            20                  25                  30  

<210>  25
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  25
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Arg Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Glu Gly 
            20                  25                  30  

<210>  26
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  26
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Val Ala Trp Leu Glu Gly Glu Gly 
            20                  25                  30  

<210>  27
<211>  30
<212>  PRT
<213>  人工序列(Artificial Sequence)

<220>
<221>  MUTAGEN
<222>  (2)..(2)
<223>  Xaa为Aib


<220>
<221>  BINDING
<222>  (20)..(20)
<223>  Lys侧链被修饰


<400>  27
His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      
Lys Ala Ala Lys Glu Phe Ile Ala Trp Leu Glu Gly Glu Gly 
            20                  25                  30  

