序列表

<110>  华博生物医药技术（上海）有限公司
上海华奥泰生物药业股份有限公司

<120>  抗TIGIT的抗体、其制备方法和应用

<130>  0151-PA-003

<160>  73

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 VH

<400>  1

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Ile Trp Ile Arg Gln Phe Pro Gly Asn Lys Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Thr Ser Ser Gly Ser Thr Ser Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Phe Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Phe Gly Asn Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  2
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 VL

<400>  2

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln His Val Ser Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR1

<400>  3

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  4
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR2

<400>  4

Ile Thr Ser Ser Gly Ser Thr 
1               5           


<210>  5
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HCDR3

<400>  5

Ala Arg Leu Asp Phe Gly Asn Tyr Gly Gly Ala Met Asp Tyr 
1               5                   10                  


<210>  6
<211>  6
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR1

<400>  6

Gln His Val Ser Thr Ala 
1               5       


<210>  7
<211>  3
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR2

<400>  7

Ser Ala Ser 
1           


<210>  8
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  LCDR3

<400>  8

Gln Gln His Tyr Ile Thr Pro Tyr Thr 
1               5                   


<210>  9
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0031 VH

<400>  9

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Ile Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Phe Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Phe Gly Asn Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  10
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030 VL

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Val Ser Thr Ala 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0031和HB0033 VL

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln His Val Ser Thr Ala 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0032 VH

<400>  12

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Ile Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Phe Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Phe Gly Asn Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  13
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0032 VL

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln His Val Ser Thr Ala 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  14
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0033 VH

<400>  14

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Ile Trp Ile Arg Gln Pro Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Phe Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Phe Gly Asn Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  15
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030 L-FR1

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  16
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0031、HB0032和HB0033 L-FR1

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  17
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0032 L-FR2

<400>  17

Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  18
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0031和HB0033 L-FR2

<400>  18

Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  19
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030 L-FR3

<400>  19

Tyr Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  20
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0031和HB0033 L-FR3

<400>  20

Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Arg Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  21
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0032 L-FR3

<400>  21

Tyr Arg Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  22
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030、HB0031、HB0032和HB0033 L-FR4

<400>  22

Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  23
<211>  25
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030、HB0031、HB0032和HB0033 H-FR1

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser 
            20                  25  


<210>  24
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0031 H-FR2

<400>  24

Trp Ile Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  25
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0032 H-FR2

<400>  25

Trp Ile Trp Ile Arg Gln Pro Pro Gly Lys Lys Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  26
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0033 H-FR2

<400>  26

Trp Ile Trp Ile Arg Gln Pro Pro Gly Asn Lys Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  27
<211>  38
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030、HB0031、HB0032和HB0033 H-FR3

<400>  27

Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr Phe Ser Val Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  28
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030、HB0031、HB0032和HB0033 H-FR4

<400>  28

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10      


<210>  29
<211>  329
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  人IgG1恒定区野生型

<400>  29

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  30
<211>  329
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  人IgG1恒定区突变

<400>  30

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                325                 


<210>  31
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  人kappa轻链恒定区

<400>  31

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  32
<211>  119
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428VH

<400>  32

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ala Pro Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Ser Phe Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Gly Thr Asp Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Ile Val Ser Ser 
        115                 


<210>  33
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900428VL

<400>  33

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Phe Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln His Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Asn Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  34
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423VL

<400>  34

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Phe Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln His Val Ser Asn Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


His Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly 
    50                  55                  60                  


Arg Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  25
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423、900424和900428 H-FR1

<400>  35

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25  


<210>  36
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 H-FR2

<400>  36

Trp Ile Trp Ile Arg Gln Phe Pro Gly Asn Lys Val Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  37
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 H-FR2

<400>  37

Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Arg Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  38
<211>  38
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 H-FR3

<400>  38

Ser Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Phe Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Phe Leu Gln Leu Thr Ser Val Thr Thr Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  39
<211>  38
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 H-FR3

<400>  39

Arg Tyr Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Phe Leu Gln Leu Ser Phe Val Thr Thr Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  40
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 H-FR4

<400>  40

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  41
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 H-FR4

<400>  41

Trp Gly Gln Gly Thr Ser Val Ile Val Ser Ser 
1               5                   10      


<210>  42
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 HCDR2

<400>  42

Ile Ser Tyr Ser Gly Ala Pro 
1               5           


<210>  43
<211>  12
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 HCDR3

<400>  43

Ala Ser Leu Gly Thr Asp Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  44
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 L-FR1

<400>  44

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  45
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 L-FR1

<400>  45

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Phe Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser 
            20                  25      


<210>  46
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 L-FR2

<400>  46

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  47
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 L-FR2

<400>  47

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


His 
    


<210>  48
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900428 L-FR3

<400>  48

Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Arg Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Phe Thr Ile Asn Ser Val Gln Ala Glu Asp Leu Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  49
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 L-FR3

<400>  49

Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Arg Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  50
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423 L-FR3

<400>  50

Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Ile Gly Arg Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala 
            20                  25                  30          


Val Tyr Tyr Cys 
        35      


<210>  51
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423、900424和900428 L-FR4

<400>  51

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  52
<211>  6
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 LCDR1

<400>  52

Gln His Val Ser Asn Ala 
1               5       


<210>  53
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 LCDR3

<400>  53

Gln Gln Tyr Tyr Ser Leu Pro Trp Thr 
1               5                   


<210>  54
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0031 VH; HB0032 VH; HB0033 VH

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = Lys或Asn

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = Gly或Lys

<400>  54

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Ile Trp Ile Arg Gln Pro Pro Gly Xaa Xaa Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Thr Ser Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Phe Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Asp Phe Gly Asn Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  55
<211>  121
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 VH; HB0030和HB0031 VH; HB0032 VH; HB0033 VH; 900423和900428VH

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = Asp或Gln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = Glu或Gln

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa = Ile或Asn

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa = Phe或Pro

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa = Lys或Asn

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa = Gly、Lys或Arg

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = Ile或Met

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = Ser或Tyr

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa = Pro或Thr

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa = Arg、Ser或Tyr

<220>
<221>  misc_feature
<222>  (68)..(68)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa = Phe或Ile

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa = Arg或Val

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (82)..(82)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (84)..(84)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa = Ala或Glu

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa = Arg或Ser

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa = Phe或Thr

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (103)..(103)
<223>  Xaa = Asn或Tyr

<220>
<221>  misc_feature
<222>  (105)..(105)
<223>  Xaa = Gly或不存在

<220>
<221>  misc_feature
<222>  (106)..(106)
<223>  Xaa = Gly或不存在

<220>
<221>  misc_feature
<222>  (116)..(116)
<223>  Xaa = Leu或Ser

<220>
<221>  misc_feature
<222>  (118)..(118)
<223>  Xaa = Ile或Thr

<400>  55

Xaa Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Xaa 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Thr Val Xaa Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Xaa Trp Ile Arg Gln Xaa Pro Gly Xaa Xaa Xaa Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile Xaa Xaa Ser Gly Xaa Xaa Xaa Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Xaa Xaa Xaa Xaa Xaa Asp Thr Ser Lys Asn Gln Phe Xaa 
65                  70                  75                  80  


Leu Xaa Leu Xaa Xaa Val Thr Xaa Xaa Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Xaa Leu Xaa Xaa Xaa Xaa Tyr Xaa Xaa Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Xaa Val Xaa Val Ser Ser 
        115                 120     


<210>  56
<211>  7
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424、HB0030、HB0031、HB0032和HB0033 HCDR2; 900423和900428 HCDR2

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Ser或Tyr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Pro或Thr

<400>  56

Ile Xaa Xaa Ser Gly Xaa Xaa 
1               5           


<210>  57
<211>  14
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423和900428 HCDR3; 900424、HB0030、HB0031、HB0032和HB0033 HCDR3

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Arg或Ser

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Phe或Thr

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Asp或Gly

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Asn或Tyr

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Gly或不存在

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Gly或不存在

<400>  57

Ala Xaa Leu Xaa Xaa Xaa Xaa Tyr Xaa Xaa Ala Met Asp Tyr 
1               5                   10                  


<210>  58
<211>  25
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030、HB0031、HB0032和HB0033 H-FR1; 900423、900424和900428 H-FR1

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = Asp或Gln

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa = Glu或Gln

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa = Ser或Thr

<400>  58

Xaa Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Xaa 
1               5                   10                  15      


Xaa Leu Ser Leu Thr Cys Thr Val Xaa 
            20                  25  


<210>  59
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0031 H-FR2; HB0032 H-FR2; HB0033 H-FR2

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Lys或Asn

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Gly或Lys

<400>  59

Trp Ile Trp Ile Arg Gln Pro Pro Gly Xaa Xaa Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  60
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0031 H-FR2; HB0032 H-FR2; HB0033 H-FR2; 
900424 H-FR2; 900423和900428 H-FR2

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Ile或Asn

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa = Phe或Pro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Lys或Asn

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Gly、Lys或Arg

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = Ile或Met

<400>  60

Trp Xaa Trp Ile Arg Gln Xaa Pro Gly Xaa Xaa Xaa Glu Trp Xaa Gly 
1               5                   10                  15      


Tyr 
    


<210>  61
<211>  38
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030、HB0031、HB0032和HB0033 H-FR3; 900423和900428 H-FR3; 
900424 H-FR3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = Arg、Ser或Tyr

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Phe或Ile

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = Arg或Val

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = Ala或Glu

<400>  61

Xaa Tyr Asn Pro Ser Leu Lys Ser Arg Xaa Xaa Xaa Xaa Xaa Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Xaa Leu Xaa Leu Xaa Xaa Val Thr Xaa Xaa Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  62
<211>  11
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030、HB0031、HB0032和HB0033 H-FR4; 900424 H-FR4; 
900423和900428 H-FR4

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Leu或Ser

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Ile或Thr

<400>  62

Trp Gly Gln Gly Thr Xaa Val Xaa Val Ser Ser 
1               5                   10      


<210>  63
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030 VL; HB0031和HB0033 VL; HB0032 VL

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = Ala或Asn

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = Leu或Arg

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = Gln或Tyr

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa = Gly或Arg

<400>  63

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Xaa Ala Ser Gln His Val Ser Thr Ala 
            20                  25                  30          


Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Xaa Xaa Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Xaa Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Ile Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  64
<211>  107
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424 VL; HB0030 VL; HB0031和HB0033 VL; HB0032 VL; 
900423VL; 900428VL

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gln或Val

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = His或Pro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Lys或Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Leu或Met

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = Lys或Arg

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = Asn或Thr

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa = Ala或Asn

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa = His或Tyr

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa = Leu或Arg

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa = Gln或Tyr

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  Xaa = Asp或Ser

<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa = Ile、Ser或Thr

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa = Arg或Ser

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa = Gly或Arg

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (76)..(76)
<223>  Xaa = Asn或Ser

<220>
<221>  misc_feature
<222>  (78)..(78)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (80)..(80)
<223>  Xaa = Ala或Pro

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (85)..(85)
<223>  Xaa = Thr或Val

<220>
<221>  misc_feature
<222>  (91)..(91)
<223>  Xaa = His或Tyr

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa = Ile或Ser

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa = Leu或Thr

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa = Trp或Tyr

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa = Gly或Gln

<400>  64

Asp Ile Xaa Met Thr Gln Ser Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys Xaa Ala Ser Gln His Val Ser Xaa Ala 
            20                  25                  30          


Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Xaa Ser Ala Ser Tyr Xaa Xaa Xaa Gly Val Pro Xaa Arg Phe Xaa Gly 
    50                  55                  60                  


Xaa Xaa Ser Gly Thr Asp Phe Thr Xaa Thr Ile Xaa Ser Xaa Gln Xaa 
65                  70                  75                  80  


Glu Asp Xaa Ala Xaa Tyr Tyr Cys Gln Gln Xaa Tyr Xaa Xaa Pro Xaa 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  65
<211>  6
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424、HB0030、HB0031、HB0032和HB0033 LCDR1; 900423和900428 LCDR1

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Asn或Thr

<400>  65

Gln His Val Ser Xaa Ala 
1               5       


<210>  66
<211>  9
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900424、HB0030、HB0031、HB0032和HB0033 LCDR3; 900423和900428 LCDR3

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = His或Tyr

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa = Ile或Ser

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa = Leu或Thr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Trp或Tyr

<400>  66

Gln Gln Xaa Tyr Xaa Xaa Pro Xaa Thr 
1               5                   


<210>  67
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0031、HB0032和HB0033 L-FR1; HB0030 L-FR1

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = Lys或Arg

<400>  67

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Xaa Ala Ser 
            20                  25      


<210>  68
<211>  26
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030 L-FR1; HB0031、HB0032和HB0033 L-FR1; 
900424 L-FR1; 900423和900428 L-FR1

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gln或Val

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = His或Pro

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa = Lys或Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Leu或Met

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  Xaa = Phe或Ser

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Ala或Thr

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa = Ile或Val

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = Lys或Arg

<400>  68

Asp Ile Xaa Met Thr Gln Ser Xaa Xaa Xaa Xaa Xaa Xaa Ser Xaa Gly 
1               5                   10                  15      


Asp Arg Val Xaa Ile Thr Cys Xaa Ala Ser 
            20                  25      


<210>  69
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0032 L-FR2; HB0031和HB0033 L-FR2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Ala或Asn

<400>  69

Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  70
<211>  17
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030和HB0032 L-FR2; HB0031和HB0033 L-FR2; 
900424 L-FR2; 900423和900428 L-FR2

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Ala或Asn

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa = Lys或Gln

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Ala或Ser

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa = His或Tyr

<400>  70

Xaa Xaa Trp Tyr Gln Gln Lys Pro Gly Xaa Xaa Pro Lys Leu Leu Ile 
1               5                   10                  15      


Xaa 
    


<210>  71
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030 L-FR3; HB0031和HB0033 L-FR3; HB0032 L-FR3

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Leu或Arg

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gln或Tyr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = Gly或Arg

<400>  71

Tyr Xaa Xaa Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Xaa Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  72
<211>  36
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  HB0030 L-FR3; HB0031和HB0033 L-FR3; HB0032 L-FR3; 
900428 L-FR3; 900424 L-FR3; 900423 L-FR3

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa = Leu或Arg

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gln或Tyr

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa = Ser或Thr

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa = Asp或Ser

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa = Ile、Ser或Thr

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa = Arg或Ser

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa = Gly或Arg

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa = Asn或Ser

<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa = Leu或Val

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa = Ala或Pro

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa = Phe或Leu

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa = Thr或Val

<400>  72

Tyr Xaa Xaa Xaa Gly Val Pro Xaa Arg Phe Xaa Gly Xaa Xaa Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Xaa Thr Ile Xaa Ser Xaa Gln Xaa Glu Asp Xaa Ala 
            20                  25                  30          


Xaa Tyr Tyr Cys 
        35      


<210>  73
<211>  10
<212>  PRT
<213>  人工序列（Artificial Sequence）

<220>
<223>  900423、900424和900428 L-FR4; HB0030、HB0031、HB0032和HB0033 L-FR4

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa = Gly或Gln

<400>  73

Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  