                         SEQUENCE LISTING

<110>  ϴѧ
 
<120>  FGF21ƱƽֱҩеӦ

<130>  BBA201503A

<150>  CN202010396043.1
<151>  2020-05-12

<160>  14    

<170>  PatentIn version 3.3

<210>  1
<211>  178
<212>  PRT
<213>  ˹

<400>  1

Ala Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
1               5                   10                  15      


Tyr Leu Tyr Thr Asp Asp Ala Gln Arg Thr Glu Ala His Leu Glu Ile 
            20                  25                  30          


Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser 
        35                  40                  45              


Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
    50                  55                  60                  


Val Arg Thr Pro Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr 
65                  70                  75                  80  


Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
                85                  90                  95      


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
            100                 105                 110         


Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Ala Arg Phe Leu Pro Leu Pro Phe Leu Pro Pro Ala Leu Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Gly Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser 
        


<210>  2
<211>  784
<212>  PRT
<213>  ˹

<400>  2

Ala Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
1               5                   10                  15      


Tyr Leu Tyr Thr Asp Asp Ala Gln Arg Thr Glu Ala His Leu Glu Ile 
            20                  25                  30          


Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser 
        35                  40                  45              


Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
    50                  55                  60                  


Val Arg Thr Pro Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr 
65                  70                  75                  80  


Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
                85                  90                  95      


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
            100                 105                 110         


Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Ala Arg Phe Leu Pro Leu Pro Phe Leu Pro Pro Ala Leu Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Gly Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His 
        195                 200                 205             


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
    210                 215                 220                 


Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys 
225                 230                 235                 240 


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
                245                 250                 255     


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
            260                 265                 270         


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
        275                 280                 285             


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
    290                 295                 300                 


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
305                 310                 315                 320 


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
                325                 330                 335     


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
            340                 345                 350         


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
        355                 360                 365             


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
    370                 375                 380                 


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
385                 390                 395                 400 


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
                405                 410                 415     


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
            420                 425                 430         


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
        435                 440                 445             


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
    450                 455                 460                 


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
465                 470                 475                 480 


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
                485                 490                 495     


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
            500                 505                 510         


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
        515                 520                 525             


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
    530                 535                 540                 


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
545                 550                 555                 560 


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
                565                 570                 575     


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
            580                 585                 590         


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
        595                 600                 605             


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
    610                 615                 620                 


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
625                 630                 635                 640 


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
                645                 650                 655     


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
            660                 665                 670         


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
        675                 680                 685             


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu 
    690                 695                 700                 


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
705                 710                 715                 720 


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
                725                 730                 735     


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
            740                 745                 750         


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
        755                 760                 765             


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
    770                 775                 780                 


<210>  3
<211>  784
<212>  PRT
<213>  ˹

<400>  3

Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala His Arg 
1               5                   10                  15      


Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala 
            20                  25                  30          


Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val Lys Leu 
        35                  40                  45              


Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser 
    50                  55                  60                  


Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu 
65                  70                  75                  80  


Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys 
                85                  90                  95      


Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys 
            100                 105                 110         


Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val 
        115                 120                 125             


Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr 
    130                 135                 140                 


Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu 
145                 150                 155                 160 


Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln 
                165                 170                 175     


Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg 
            180                 185                 190         


Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser 
        195                 200                 205             


Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg 
    210                 215                 220                 


Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu 
225                 230                 235                 240 


Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu 
                245                 250                 255     


Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu 
            260                 265                 270         


Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro 
        275                 280                 285             


Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met 
    290                 295                 300                 


Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp 
305                 310                 315                 320 


Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe 
                325                 330                 335     


Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu 
            340                 345                 350         


Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala 
        355                 360                 365             


Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys 
    370                 375                 380                 


Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu 
385                 390                 395                 400 


Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg 
                405                 410                 415     


Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val 
            420                 425                 430         


Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu 
        435                 440                 445             


Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn 
    450                 455                 460                 


Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr 
465                 470                 475                 480 


Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala 
                485                 490                 495     


Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr 
            500                 505                 510         


Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln 
        515                 520                 525             


Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys 
    530                 535                 540                 


Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe 
545                 550                 555                 560 


Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu 
                565                 570                 575     


Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly 
            580                 585                 590         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp 
        595                 600                 605             


Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu 
    610                 615                 620                 


Tyr Thr Asp Asp Ala Gln Arg Thr Glu Ala His Leu Glu Ile Arg Glu 
625                 630                 635                 640 


Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu 
                645                 650                 655     


Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Arg 
            660                 665                 670         


Thr Pro Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser 
        675                 680                 685             


Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu 
    690                 695                 700                 


Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His 
705                 710                 715                 720 


Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro 
                725                 730                 735     


Ala Arg Phe Leu Pro Leu Pro Phe Leu Pro Pro Ala Leu Pro Glu Pro 
            740                 745                 750         


Pro Gly Ile Leu Gly Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro 
        755                 760                 765             


Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
    770                 775                 780                 


<210>  4
<211>  398
<212>  PRT
<213>  ˹

<400>  4

Ala Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg 
1               5                   10                  15      


Tyr Leu Tyr Thr Asp Asp Ala Gln Arg Thr Glu Ala His Leu Glu Ile 
            20                  25                  30          


Arg Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser 
        35                  40                  45              


Leu Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly 
    50                  55                  60                  


Val Arg Thr Pro Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr 
65                  70                  75                  80  


Gly Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu 
                85                  90                  95      


Leu Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro 
            100                 105                 110         


Leu His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg 
        115                 120                 125             


Gly Pro Ala Arg Phe Leu Pro Leu Pro Phe Leu Pro Pro Ala Leu Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Gly Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            180                 185                 190         


Ser Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe 
        195                 200                 205             


Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr 
    210                 215                 220                 


Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser 
225                 230                 235                 240 


Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala 
                245                 250                 255     


Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln 
            260                 265                 270         


Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys 
        275                 280                 285             


Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu 
    290                 295                 300                 


Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe 
305                 310                 315                 320 


Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile 
                325                 330                 335     


Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala 
            340                 345                 350         


Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val 
        355                 360                 365             


Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu 
    370                 375                 380                 


Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
385                 390                 395             


<210>  5
<211>  398
<212>  PRT
<213>  ˹

<400>  5

Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
1               5                   10                  15      


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
            20                  25                  30          


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
        35                  40                  45              


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
    50                  55                  60                  


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
65                  70                  75                  80  


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
                85                  90                  95      


Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu 
            100                 105                 110         


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr 
        115                 120                 125             


Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys 
    130                 135                 140                 


Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr 
145                 150                 155                 160 


Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu 
                165                 170                 175     


Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly 
            180                 185                 190         


Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly 
        195                 200                 205             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Asp Ser Ser 
    210                 215                 220                 


Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr Leu Tyr Thr 
225                 230                 235                 240 


Asp Asp Ala Gln Arg Thr Glu Ala His Leu Glu Ile Arg Glu Asp Gly 
                245                 250                 255     


Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu Leu Gln Leu 
            260                 265                 270         


Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val Arg Thr Pro 
        275                 280                 285             


Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly Ser Leu His 
    290                 295                 300                 


Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu Glu Asp Gly 
305                 310                 315                 320 


Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu His Leu Pro 
                325                 330                 335     


Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly Pro Ala Arg 
            340                 345                 350         


Phe Leu Pro Leu Pro Phe Leu Pro Pro Ala Leu Pro Glu Pro Pro Gly 
        355                 360                 365             


Ile Leu Gly Pro Gln Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser 
    370                 375                 380                 


Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
385                 390                 395             


<210>  6
<211>  537
<212>  DNA
<213>  ˹

<400>  6
gcagactcca gtcctctcct gcaattcggg ggccaagtcc ggcagcggta cctctacaca     60

gatgatgccc agcgtacaga agcccacctg gagatcaggg aggatgggac ggtggggggc    120

gctgctgacc agagccccga aagtctcctg cagctgaaag ccttgaagcc gggagttatt    180

caaatcttgg gagtccgtac accgaggttc ctgtgccagc ggccagatgg ggccctgtat    240

ggatcgctcc actttgaccc tgaggcctgc agcttccggg agctgcttct tgaggacgga    300

tacaatgttt accagtccga agcccacggc ctcccgctgc acctgccagg gaacaagtcc    360

ccacaccggg accctgcacc ccgaggacca gctcgcttcc tgccactacc attcctgccc    420

cccgcactcc cggagccacc cggaatcctg ggtccccagc cccccgatgt gggctcctcg    480

gaccctctga gcatggtggg accttcccag ggccgaagcc ccagctacgc ttcctga       537


<210>  7
<211>  2355
<212>  DNA
<213>  ˹

<400>  7
gcagactcca gtcctctcct gcaattcggg ggccaagtcc ggcagcggta cctctacaca     60

gatgatgccc agcgtacaga agcccacctg gagatcaggg aggatgggac ggtggggggc    120

gctgctgacc agagccccga aagtctcctg cagctgaaag ccttgaagcc gggagttatt    180

caaatcttgg gagtccgtac accgaggttc ctgtgccagc ggccagatgg ggccctgtat    240

ggatcgctcc actttgaccc tgaggcctgc agcttccggg agctgcttct tgaggacgga    300

tacaatgttt accagtccga agcccacggc ctcccgctgc acctgccagg gaacaagtcc    360

ccacaccggg accctgcacc ccgaggacca gctcgcttcc tgccactacc attcctgccc    420

cccgcactcc cggagccacc cggaatcctg ggtccccagc cccccgatgt gggctcctcg    480

gaccctctga gcatggtggg accttcccag ggccgaagcc ccagctacgc ttccggtggt    540

ggtggttctg gtggtggtgg ttctggtggt ggtggttcta gaggtgtttt cagaagagac    600

gctcacaagt ctgaagttgc tcacagattc aaggacttgg gtgaagaaaa cttcaaggct    660

ttggttttga tcgctttcgc tcaatacttg caacaatgtc cattcgaaga ccacgttaag    720

ttggttaacg aagttactga atttgctaag acttgtgttg ctgacgaatc tgctgaaaac    780

tgtgacaagt ctttgcacac tttgttcggt gacaagttgt gtactgttgc tactttgaga    840

gaaacttacg gtgaaatggc tgactgttgt gctaagcaag aaccagaaag aaacgaatgt    900

ttcttgcaac acaaggacga caacccaaac ttgccaagat tggttagacc agaagttgac    960

gttatgtgta ctgctttcca cgacaacgaa gaaactttct tgaagaagta cttgtacgaa   1020

atcgctagaa gacacccata cttctacgct ccagaattgt tgttcttcgc taagagatac   1080

aaggctgctt tcactgaatg ttgtcaagct gctgacaagg ctgcttgttt gttgccaaag   1140

ttggacgaat tgagagacga aggtaaggct tcttctgcta agcaaagatt gaagtgtgct   1200

tctttgcaaa agttcggtga aagagctttc aaggcttggg ctgttgctag attgtctcaa   1260

agattcccaa aggctgaatt tgctgaagtt tctaagttgg ttactgactt gactaaggtt   1320

cacactgaat gttgtcacgg tgacttgttg gaatgtgctg acgacagagc tgacttggct   1380

aagtacatct gtgaaaacca agactctatc tcttctaagt tgaaggaatg ttgtgaaaag   1440

ccattgttgg aaaagtctca ctgtatcgct gaagttgaaa acgacgaaat gccagctgac   1500

ttgccatctt tggctgctga cttcgttgaa tctaaggacg tttgtaagaa ctacgctgaa   1560

gctaaggacg ttttcttggg tatgttcttg tacgaatacg ctagaagaca cccagactac   1620

tctgttgttt tgttgttgag attggctaag acttacgaaa ctactttgga aaagtgttgt   1680

gctgctgctg acccacacga atgttacgct aaggttttcg acgaatttaa gccattggtt   1740

gaagaaccac aaaacttgat caagcaaaac tgtgaattgt tcgaacaatt gggtgaatac   1800

aagttccaaa acgctttgtt ggttagatac actaagaagg ttccacaagt ttctactcca   1860

actttggttg aagtttctag aaacttgggt aaggttggtt ctaagtgttg taagcaccca   1920

gaagctaaga gaatgccatg tgctgaagac tacttgtctg ttgttttgaa ccaattgtgt   1980

gttttgcacg aaaagactcc agtttctgac agagttacta agtgttgtac tgaatctttg   2040

gttaacagaa gaccatgttt ctctgctttg gaagttgacg aaacttacgt tccaaaggaa   2100

tttaacgctg aaactttcac tttccacgct gacatctgta ctttgtctga aaaggaaaga   2160

caaatcaaga agcaaactgc tttggttgaa ttggttaagc acaagccaaa ggctactaag   2220

gaacaattga aggctgttat ggacgacttc gctgctttcg ttgaaaagtg ttgtaaggct   2280

gacgacaagg aaacttgttt cgctgaagaa ggtaagaagt tggttgctgc ttctcaagct   2340

gctttgggtt tgtga                                                    2355


<210>  8
<211>  2355
<212>  DNA
<213>  ˹

<400>  8
agaggtgttt tcagaagaga cgctcacaag tctgaagttg ctcacagatt caaggacttg     60

ggtgaagaaa acttcaaggc tttggttttg atcgctttcg ctcaatactt gcaacaatgt    120

ccattcgaag accacgttaa gttggttaac gaagttactg aatttgctaa gacttgtgtt    180

gctgacgaat ctgctgaaaa ctgtgacaag tctttgcaca ctttgttcgg tgacaagttg    240

tgtactgttg ctactttgag agaaacttac ggtgaaatgg ctgactgttg tgctaagcaa    300

gaaccagaaa gaaacgaatg tttcttgcaa cacaaggacg acaacccaaa cttgccaaga    360

ttggttagac cagaagttga cgttatgtgt actgctttcc acgacaacga agaaactttc    420

ttgaagaagt acttgtacga aatcgctaga agacacccat acttctacgc tccagaattg    480

ttgttcttcg ctaagagata caaggctgct ttcactgaat gttgtcaagc tgctgacaag    540

gctgcttgtt tgttgccaaa gttggacgaa ttgagagacg aaggtaaggc ttcttctgct    600

aagcaaagat tgaagtgtgc ttctttgcaa aagttcggtg aaagagcttt caaggcttgg    660

gctgttgcta gattgtctca aagattccca aaggctgaat ttgctgaagt ttctaagttg    720

gttactgact tgactaaggt tcacactgaa tgttgtcacg gtgacttgtt ggaatgtgct    780

gacgacagag ctgacttggc taagtacatc tgtgaaaacc aagactctat ctcttctaag    840

ttgaaggaat gttgtgaaaa gccattgttg gaaaagtctc actgtatcgc tgaagttgaa    900

aacgacgaaa tgccagctga cttgccatct ttggctgctg acttcgttga atctaaggac    960

gtttgtaaga actacgctga agctaaggac gttttcttgg gtatgttctt gtacgaatac   1020

gctagaagac acccagacta ctctgttgtt ttgttgttga gattggctaa gacttacgaa   1080

actactttgg aaaagtgttg tgctgctgct gacccacacg aatgttacgc taaggttttc   1140

gacgaattta agccattggt tgaagaacca caaaacttga tcaagcaaaa ctgtgaattg   1200

ttcgaacaat tgggtgaata caagttccaa aacgctttgt tggttagata cactaagaag   1260

gttccacaag tttctactcc aactttggtt gaagtttcta gaaacttggg taaggttggt   1320

tctaagtgtt gtaagcaccc agaagctaag agaatgccat gtgctgaaga ctacttgtct   1380

gttgttttga accaattgtg tgttttgcac gaaaagactc cagtttctga cagagttact   1440

aagtgttgta ctgaatcttt ggttaacaga agaccatgtt tctctgcttt ggaagttgac   1500

gaaacttacg ttccaaagga atttaacgct gaaactttca ctttccacgc tgacatctgt   1560

actttgtctg aaaaggaaag acaaatcaag aagcaaactg ctttggttga attggttaag   1620

cacaagccaa aggctactaa ggaacaattg aaggctgtta tggacgactt cgctgctttc   1680

gttgaaaagt gttgtaaggc tgacgacaag gaaacttgtt tcgctgaaga aggtaagaag   1740

ttggttgctg cttctcaagc tgctttgggt ttgggtggtg gtggttctgg tggtggtggt   1800

tctggtggtg gtggttctgc agactccagt cctctcctgc aattcggggg ccaagtccgg   1860

cagcggtacc tctacacaga tgatgcccag cgtacagaag cccacctgga gatcagggag   1920

gatgggacgg tggggggcgc tgctgaccag agccccgaaa gtctcctgca gctgaaagcc   1980

ttgaagccgg gagttattca aatcttggga gtccgtacac cgaggttcct gtgccagcgg   2040

ccagatgggg ccctgtatgg atcgctccac tttgaccctg aggcctgcag cttccgggag   2100

ctgcttcttg aggacggata caatgtttac cagtccgaag cccacggcct cccgctgcac   2160

ctgccaggga acaagtcccc acaccgggac cctgcacccc gaggaccagc tcgcttcctg   2220

ccactaccat tcctgccccc cgcactcccg gagccacccg gaatcctggg tccccagccc   2280

cccgatgtgg gctcctcgga ccctctgagc atggtgggac cttcccaggg ccgaagcccc   2340

agctacgctt cctga                                                    2355


<210>  9
<211>  1197
<212>  DNA
<213>  ˹

<400>  9
gcagactcca gtcctctcct gcaattcggg ggccaagtcc ggcagcggta cctctacaca     60

gatgatgccc agcgtacaga agcccacctg gagatcaggg aggatgggac ggtggggggc    120

gctgctgacc agagccccga aagtctcctg cagctgaaag ccttgaagcc gggagttatt    180

caaatcttgg gagtccgtac accgaggttc ctgtgccagc ggccagatgg ggccctgtat    240

ggatcgctcc actttgaccc tgaggcctgc agcttccggg agctgcttct tgaggacgga    300

tacaatgttt accagtccga agcccacggc ctcccgctgc acctgccagg gaacaagtcc    360

ccacaccggg accctgcacc ccgaggacca gctcgcttcc tgccactacc attcctgccc    420

cccgcactcc cggagccacc cggaatcctg ggtccccagc cccccgatgt gggctcctcg    480

gaccctctga gcatggtggg accttcccag ggccgaagcc ccagctacgc ttccggtggt    540

ggtggttctg gtggtggtgg ttctggtggt ggtggttctg ttgaagaacc acaaaacttg    600

atcaagcaaa actgtgaatt gttcgaacaa ttgggtgaat acaagttcca aaacgctttg    660

ttggttagat acactaagaa ggttccacaa gtttctactc caactttggt tgaagtttct    720

agaaacttgg gtaaggttgg ttctaagtgt tgtaagcacc cagaagctaa gagaatgcca    780

tgtgctgaag actacttgtc tgttgttttg aaccaattgt gtgttttgca cgaaaagact    840

ccagtttctg acagagttac taagtgttgt actgaatctt tggttaacag aagaccatgt    900

ttctctgctt tggaagttga cgaaacttac gttccaaagg aattcaacgc tgaaactttc    960

actttccacg ctgacatctg tactttgtct gaaaaggaaa gacaaatcaa gaagcaaact   1020

gctttggttg aattggttaa gcacaagcca aaggctacta aggaacaatt gaaggctgtt   1080

atggacgact tcgctgcttt cgttgaaaag tgttgtaagg ctgacgacaa ggaaacttgt   1140

ttcgctgaag aaggtaagaa gttggttgct gcttctcaag ctgctttggg tttgtaa      1197


<210>  10
<211>  1197
<212>  DNA
<213>  ˹

<400>  10
gttgaagaac cacaaaactt gatcaagcaa aactgtgaat tgttcgaaca attgggtgaa     60

tacaagttcc aaaacgcttt gttggttaga tacactaaga aggttccaca agtttctact    120

ccaactttgg ttgaagtttc tagaaacttg ggtaaggttg gttctaagtg ttgtaagcac    180

ccagaagcta agagaatgcc atgtgctgaa gactacttgt ctgttgtttt gaaccaattg    240

tgtgttttgc acgaaaagac tccagtttct gacagagtta ctaagtgttg tactgaatct    300

ttggttaaca gaagaccatg tttctctgct ttggaagttg acgaaactta cgttccaaag    360

gaattcaacg ctgaaacttt cactttccac gctgacatct gtactttgtc tgaaaaggaa    420

agacaaatca agaagcaaac tgctttggtt gaattggtta agcacaagcc aaaggctact    480

aaggaacaat tgaaggctgt tatggacgac ttcgctgctt tcgttgaaaa gtgttgtaag    540

gctgacgaca aggaaacttg tttcgctgaa gaaggtaaga agttggttgc tgcttctcaa    600

gctgctttgg gtttgggtgg tggtggttct ggtggtggtg gttctggtgg tggtggttct    660

gcagactcca gtcctctcct gcaattcggg ggccaagtcc ggcagcggta cctctacaca    720

gatgatgccc agcgtacaga agcccacctg gagatcaggg aggatgggac ggtggggggc    780

gctgctgacc agagccccga aagtctcctg cagctgaaag ccttgaagcc gggagttatt    840

caaatcttgg gagtccgtac accgaggttc ctgtgccagc ggccagatgg ggccctgtat    900

ggatcgctcc actttgaccc tgaggcctgc agcttccggg agctgcttct tgaggacgga    960

tacaatgttt accagtccga agcccacggc ctcccgctgc acctgccagg gaacaagtcc   1020

ccacaccggg accctgcacc ccgaggacca gctcgcttcc tgccactacc attcctgccc   1080

cccgcactcc cggagccacc cggaatcctg ggtccccagc cccccgatgt gggctcctcg   1140

gaccctctga gcatggtggg accttcccag ggccgaagcc ccagctacgc ttcctaa      1197


<210>  11
<211>  178
<212>  PRT
<213>  ˹

<400>  11

Met Arg Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Cys Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro 
    130                 135                 140                 


Glu Pro Pro Gly Ile Leu Ala Pro Gln Pro Pro Asp Val Gly Ser Ser 
145                 150                 155                 160 


Asp Pro Leu Ser Met Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr 
                165                 170                 175     


Ala Ser 
        


<210>  12
<211>  189
<212>  PRT
<213>  ˹

<400>  12

Met Arg Asp Ser Ser Pro Leu Val His Tyr Gly Trp Gly Asp Pro Ile 
1               5                   10                  15      


Arg Leu Arg His Leu Tyr Thr Ser Gly Pro His Gly Leu Ser Ser Cys 
            20                  25                  30          


Phe Leu Arg Ile Arg Ala Asp Gly Val Val Asp Cys Ala Arg Gly Gln 
        35                  40                  45              


Ser Ala His Ser Leu Leu Glu Ile Lys Ala Val Ala Leu Arg Thr Val 
    50                  55                  60                  


Ala Ile Lys Gly Val His Ser Val Arg Tyr Leu Cys Met Gly Ala Asp 
65                  70                  75                  80  


Gly Lys Met Gln Gly Leu Leu Gln Tyr Ser Glu Glu Asp Cys Ala Phe 
                85                  90                  95      


Glu Glu Glu Ile Arg Pro Asp Gly Tyr Asn Val Tyr Arg Ser Glu Lys 
            100                 105                 110         


His Arg Leu Pro Val Cys Leu Ser Ser Ala Lys Gln Arg Gln Leu Tyr 
        115                 120                 125             


Lys Asn Arg Gly Phe Leu Pro Leu Cys His Phe Leu Pro Met Leu Pro 
    130                 135                 140                 


Met Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp 
145                 150                 155                 160 


Met Phe Ser Ser Pro Pro Asp Val Gly Ser Ser Asp Pro Leu Ser Met 
                165                 170                 175     


Val Gly Pro Ser Gln Gly Arg Ser Pro Ser Tyr Ala Ser 
            180                 185                 


<210>  13
<211>  221
<212>  PRT
<213>  ˹

<400>  13

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Cys His Phe Leu Pro Met Leu Pro Met 
                165                 170                 175     


Val Pro Glu Glu Pro Glu Asp Leu Arg Gly His Leu Glu Ser Asp Met 
            180                 185                 190         


Phe Ser Ser Pro Leu Glu Thr Asp Ser Met Asp Pro Phe Gly Leu Val 
        195                 200                 205             


Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe Glu Lys 
    210                 215                 220     


<210>  14
<211>  210
<212>  PRT
<213>  ˹

<400>  14

Met Asp Ser Asp Glu Thr Gly Phe Glu His Ser Gly Leu Trp Val Ser 
1               5                   10                  15      


Val Leu Ala Gly Leu Leu Leu Gly Ala Cys Gln Ala His Pro Ile Pro 
            20                  25                  30          


Asp Ser Ser Pro Leu Leu Gln Phe Gly Gly Gln Val Arg Gln Arg Tyr 
        35                  40                  45              


Leu Tyr Thr Asp Asp Ala Gln Gln Thr Glu Ala His Leu Glu Ile Arg 
    50                  55                  60                  


Glu Asp Gly Thr Val Gly Gly Ala Ala Asp Gln Ser Pro Glu Ser Leu 
65                  70                  75                  80  


Leu Gln Leu Lys Ala Leu Lys Pro Gly Val Ile Gln Ile Leu Gly Val 
                85                  90                  95      


Lys Thr Ser Arg Phe Leu Cys Gln Arg Pro Asp Gly Ala Leu Tyr Gly 
            100                 105                 110         


Ser Leu His Phe Asp Pro Glu Ala Cys Ser Phe Arg Glu Leu Leu Leu 
        115                 120                 125             


Glu Asp Gly Tyr Asn Val Tyr Gln Ser Glu Ala His Gly Leu Pro Leu 
    130                 135                 140                 


His Leu Pro Gly Asn Lys Ser Pro His Arg Asp Pro Ala Pro Arg Gly 
145                 150                 155                 160 


Pro Ala Arg Phe Leu Pro Leu Pro Gly Leu Pro Pro Ala Leu Pro Glu 
                165                 170                 175     


Pro Pro Gly Ile Leu Ala Pro Gln Pro Leu Glu Thr Asp Ser Met Asp 
            180                 185                 190         


Pro Phe Gly Leu Val Thr Gly Leu Glu Ala Val Arg Ser Pro Ser Phe 
        195                 200                 205             


Glu Lys 
    210 




