                         SEQUENCE LISTING

<110>  Universidade Federal do ABC
 
<120>  ANTICORPOS RECOMBINANTES HUMANOS PARA INIBIO DA CALICRENA 
       TECIDUAL HUMANA 7 (KLK7) E USO EM DOENAS RELACIONADAS AO 
       PROCESSO DE DESCAMAO DA PELE

<130>  Anticorpos recombinantes humanos para inibio de calicrena 
       tecidual humana 7 (KLK7)

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  804
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  1
ccatggccca ggtacagctg cagcagtcag gcccaggact ggtgcagcct tcggagaccc       60

tgtccctcac gtgcactgtc tctggtggct ccatgaatag ttactattgg agctggatcc      120

ggcagcccgc cgggaaggga ctggagtgga tcgggcgtgt ctatcccact gggggaaccg      180

actacaaccc ctccctcaag agtcgagtca taatgtcagt agacacggtt cggaaccact      240

tctccctgag attgaactct gtgaccgccg cggactcggc cgtgtattac tgtgcgagag      300

atcggggcta cagtaactac ggctggttcg acccctgggg ccagggaacc ctggtcaacg      360

tctcctcagg gagtgcatcc gccccaaagc ttgaagaagg tgaattttca gaagcacgcg      420

taaattttat gctgactcag ccccactctg tgtcggcgtc tccggggaag acggtaacca      480

tctcctgcac cggcagcagt ggcagcattg ccagcaactt tgtacagtgg taccagcagc      540

gcccgggcag tgcccccacc actgtgatct atgaagataa tcaaagaccc tctggggtcc      600

ctgatcggtt ctccggctcc atcgacagtt cgtccaactc tgcctccctc agcatctctg      660

gactgcagac tgacgacgag gctgactact actgtcagtc ttctgatagc agcaatcacg      720

tggtgttcgg cggagggacc aagctgaccg tcctaggtca gcccaaggct gccccctcgg      780

tcactctgtt cccaccgtcc tctg                                             804


<210>  2
<211>  498
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  2

Met Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Gln Pro 
1               5                   10                  15      


Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Met Asn 
            20                  25                  30          


Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Arg Val Tyr Pro Thr Gly Gly Thr Asp Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Ile Met Ser Val Asp Thr Val Arg Asn His Phe 
65                  70                  75                  80  


Ser Leu Arg Leu Asn Ser Val Thr Ala Ala Asp Ser Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Asp Arg Gly Tyr Ser Asn Tyr Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Asn Val Ser Ser Gly Ser Ala Ser Ala Pro 
        115                 120                 125             


Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Asn Phe Met Leu 
    130                 135                 140                 


Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys Thr Val Thr Ile 
145                 150                 155                 160 


Ser Cys Thr Gly Ser Ser Gly Ser Ile Ala Ser Asn Phe Val Gln Trp 
                165                 170                 175     


Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val Ile Tyr Glu Asp 
            180                 185                 190         


Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp 
        195                 200                 205             


Ser Ser Ser Asn Ser Ala Ser Leu Ser Ile Ser Gly Leu Gln Thr Asp 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Ser Asp Ser Ser Asn His Val 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  3
<211>  801
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  3
ccatggccca ggttcagctg gtgcagtctg ggggaggcgt ggtccagcct gggaggtccc       60

tgagactctc ctgtgcagcc tctggattca tcttcagtga ttattctatg cattgggtcc      120

gccaggctcc aggcaagggg ctggagtggg tggcagttat gtcatatgat gcaaggagtc      180

aattctacgc agactccgtg aagggccgat tcaccatctc cagagacaat tccaagaaca      240

ctctatatct gcaaatgaac agcctgagag aggaagacac ggctgtgtat tactgtgcga      300

cagatgttgg caattccccg tttgactact ggggccaggg aaccctggtc accgtctcct      360

cagggagtgc atccgcccca aagcttgaag aaggtgaatt ttcagaagca cgcgtacagg      420

ctgtgctgac tcagcccccc tcagtgtctg gggccctagg gcagagggtc accatctcct      480

gcactgggag cagctccaac atcggggcgc cttatgatgt acactggtac cagcagcttc      540

caggaacagc ccccaaactc ctcatatacg gtaataacaa tcggccctca ggggtccctg      600

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggctccggt      660

ccgaggatga ggctgattat tactgtgcag catgggatga cagcctgagt ggttcttggg      720

tgttcggcgg agggaccaag ctgaccgtcc taggtcagcc caaggctgcc ccctcggtca      780

ctctgttccc accgtcctct g                                                801


<210>  4
<211>  497
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  4

Met Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro 
1               5                   10                  15      


Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          


Asp Tyr Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ala Val Met Ser Tyr Asp Ala Arg Ser Gln Phe Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Glu Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Asp Val Gly Asn Ser Pro Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ala Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Val Ser Gly Ala Leu Gly Gln Arg Val Thr Ile Ser Cys 
145                 150                 155                 160 


Thr Gly Ser Ser Ser Asn Ile Gly Ala Pro Tyr Asp Val His Trp Tyr 
                165                 170                 175     


Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Asn 
            180                 185                 190         


Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
        195                 200                 205             


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Ser Trp Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
                245                 250                 255     


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys 
    


<210>  5
<211>  819
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  5
ccatggccca ggtgcagctg caggagtccg ggggaggctt ggtaaagcct ggggggtccc       60

ttagactctc ctgtgcagcc tctggattca ctttcagtaa cgcctggatg agctgggtcc      120

gccaggctcc agggaagggg ctggagtggg ttggccgtat taaaagcaaa actgatggtg      180

ggacaacaga ctacgctgca cccgtgaaag gcagattcac catctcaaga gatgattcaa      240

aaaacacgct gtatctgcaa atgaacagcc tgaaaaccga ggacacagcc gtgtattact      300

gtaccacagg gttggtcctt tattgtggtg gtgactgcta tccgtttgac tactggggcc      360

agggaaccct ggtcaccgtc tcctcaggga gtgcatccgc cccaaagctt gaagaaggtg      420

aattttcaga agcacgcgta ctgcctgtgc tgactcagcc accctcagcg tctgggaccc      480

ccgggcagag ggtcaccatc tcttgttctg gaagcagctc caacatcgaa acaaatactt      540

tgagctggta ccaacaactc ccaggaaggg cccccaaact cctcatgcat aatgataatg      600

agcggccccc aggggtccct gaccgattct ctggctccaa gtctggcacc tcagcctccc      660

tggccatcag tgggctccaa tctgaggatg aggctgatta ttactgtgca gcatgggatg      720

acagtttgaa tggtcaggtg ttcggcggag ggaccaaggt gaccgtctta ggtcagccca      780

aggctgcccc ctcggtcact ctgttcccgc cgtcctctg                             819


<210>  6
<211>  503
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  6

Met Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Lys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr 
    50                  55                  60                  


Ala Ala Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys 
65                  70                  75                  80  


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala 
                85                  90                  95      


Val Tyr Tyr Cys Thr Thr Gly Leu Val Leu Tyr Cys Gly Gly Asp Cys 
            100                 105                 110         


Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Ser Ala Ser Ala Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala 
    130                 135                 140                 


Arg Val Leu Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro 
145                 150                 155                 160 


Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu 
                165                 170                 175     


Thr Asn Thr Leu Ser Trp Tyr Gln Gln Leu Pro Gly Arg Ala Pro Lys 
            180                 185                 190         


Leu Leu Met His Asn Asp Asn Glu Arg Pro Pro Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly 
    210                 215                 220                 


Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp 
225                 230                 235                 240 


Ser Leu Asn Gly Gln Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
                245                 250                 255     


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
            260                 265                 270         


Ala Ala Ala Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Val Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys 
            500             


<210>  7
<211>  795
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  7
ccatggccca ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggctacag       60

tgaaaatctc ctgcaaggtt tctggataca ccttcaccga ctactacatg cactgggtgc      120

aacaggcccc tggaaaaggg cttgagtgga tgggacttgt tgatcctgaa gatggtgaaa      180

caatatacgc agagaagttc cagggcagag tcaccataac cgcggacacg tctacagaca      240

cagcctacat ggagctgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcaa      300

caggcaatgt acgtaggata gactactggg gccagggaac cctggtcacc gtctcctcag      360

ggagtgcatc cgccccaaag cttgaagaag gtgaattttc agaagcacgc gtaaatttta      420

tgctgactca gccccactct gtgtcggagt ctccggggaa gacggtaacc atctcctgca      480

ccggcagcag tggcagcatt gccgacaact atgtgcagtg gtaccagcag cgcccgggca      540

gtgcccccat caatgtgatc tatgaggata accaaagacc ctctggggtc cctgatcggt      600

tctctggctc catcgacagc tcctccaact ctgcctccct caccatctct ggactgaaga      660

ctgaggacga ggctgactac tactgtcagt cttatgatag cagcaatcat gtggtattcg      720

gcggagggac caagctgacc gtcctaggtc agcccaaggc tgccccctcg gtcactctgt      780

tcccaccgtc ttctg                                                       795


<210>  8
<211>  495
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  8

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ala Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr 
            20                  25                  30          


Asp Tyr Tyr Met His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Leu Val Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Glu 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gly Asn Val Arg Arg Ile Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Lys Leu Glu 
        115                 120                 125             


Glu Gly Glu Phe Ser Glu Ala Arg Val Asn Phe Met Leu Thr Gln Pro 
    130                 135                 140                 


His Ser Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr 
145                 150                 155                 160 


Gly Ser Ser Gly Ser Ile Ala Asp Asn Tyr Val Gln Trp Tyr Gln Gln 
                165                 170                 175     


Arg Pro Gly Ser Ala Pro Ile Asn Val Ile Tyr Glu Asp Asn Gln Arg 
            180                 185                 190         


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser 
        195                 200                 205             


Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser Asn His Val Val Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
                245                 250                 255     


Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp Lys Thr His 
            260                 265                 270         


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        275                 280                 285             


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    290                 295                 300                 


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
305                 310                 315                 320 


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                325                 330                 335     


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            340                 345                 350         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        355                 360                 365             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    370                 375                 380                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
385                 390                 395                 400 


Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                405                 410                 415     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            420                 425                 430         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        435                 440                 445             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    450                 455                 460                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
465                 470                 475                 480 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495 


<210>  9
<211>  783
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  9
ccatggccca agtccagctg gtgcagtctg gggctgaggt gaagaggcct ggggcctcag       60

tgaaggtctc ctgcaaggtt tccggataca ccctcactga attatccatg cactgggtgc      120

gacaggctcc tggaaaaggg cttgagtgga tgggaggttt tgatcctgaa gatggtgaaa      180

caatctacgc acagaagttc cagggcagag tcaccatgac cgaggacaca tctacagaca      240

cagcctacat ggagctgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcaa      300

cattgaggca gtggctagaa tttgactact ggggccaggg aaccctggtc accgtctcct      360

cagggagtgc atccgcccca aagcttgaag aaggtgaatt ttcagaagca cgcgtacagt      420

ctgtgttgac gcagccgccc tcagtgtccg tgtccccagg acagacagcc agcatcacct      480

gctctggaga tagattgggg gataaatatg cttcctggta tcagcagaag ccaggccagt      540

cccctgtgct ggtcatctat caagatacca agcggccctc agggatccct gagcgattct      600

ctggctccaa ctctgggaac acagccactc tgaccatcag cgggacccag gctatggatg      660

aggctgacta ttactgtcag gcgtgggaca gcagcactgc ggtattcggc ggcgggacca      720

agctgaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc ccaccgtcct      780

ctg                                                                    783


<210>  10
<211>  491
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  10

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Arg Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30          


Glu Leu Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Leu Arg Gln Trp Leu Glu Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Lys Leu 
        115                 120                 125             


Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ser Val Leu Thr Gln 
    130                 135                 140                 


Pro Pro Ser Val Ser Val Ser Pro Gly Gln Thr Ala Ser Ile Thr Cys 
145                 150                 155                 160 


Ser Gly Asp Arg Leu Gly Asp Lys Tyr Ala Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Val Leu Val Ile Tyr Gln Asp Thr Lys Arg Pro 
            180                 185                 190         


Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala 
        195                 200                 205             


Thr Leu Thr Ile Ser Gly Thr Gln Ala Met Asp Glu Ala Asp Tyr Tyr 
    210                 215                 220                 


Cys Gln Ala Trp Asp Ser Ser Thr Ala Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
                245                 250                 255     


Pro Pro Ser Ser Ala Ala Ala Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
385                 390                 395                 400 


Glu Val Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490     


<210>  11
<211>  792
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  11
ccatggccca gctgcagcta cagcagtccg gcccaggact ggtgaagcct tcggggaccc       60

tgtccctcac ctgcgctgtc tctggtggct ccatcagcag tagtaactgg tggagttggg      120

tccgccagcc cccagggaag gggctggagt ggattgggga aatctatcat agtgggagca      180

ccaactacaa cccgtccctc aagagtcgag tcaccatatc agtagacaag tccaagaacc      240

agttctccct gaagctgagc tctgtgaccg ccgcggacac ggccgtgtat tactgtgcga      300

caggtacggc cagcttaatc ggtatggacg tctggggcca agggaccacg gtcaccgtct      360

cctcagggag tgcatccgcc ccaaagcttg aagaaggtga attttcagaa gcacgcgtat      420

cctatgtgct gactcagcca ccctcggtgt cagtggcccc aggacagacg gccaggattc      480

cctgtggggg aaataacatt ggagataaaa atgtgcagtg gtaccagcag aagccagacc      540

aggcccctgt gctggtcgtc tatgatgata gcgaccggcc ctcaggcatc cctgagcgat      600

tctctggctc caactctggg aacaaggccg ccctgaccat cagcggggtc gaggtcgggg      660

atgaggccga ctattattgt caggtgtggg ataggagttc tgatgtcgtg gtcttcggcg      720

gagggaccaa gctgaccgtc ctaggtcagc ccaaggctgc cccctcggtc actctgttcc      780

caccctcctc tg                                                          792


<210>  12
<211>  494
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  12

Met Ala Gln Leu Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro 
1               5                   10                  15      


Ser Gly Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser 
            20                  25                  30          


Ser Ser Asn Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
        35                  40                  45              


Glu Trp Ile Gly Glu Ile Tyr His Ser Gly Ser Thr Asn Tyr Asn Pro 
    50                  55                  60                  


Ser Leu Lys Ser Arg Val Thr Ile Ser Val Asp Lys Ser Lys Asn Gln 
65                  70                  75                  80  


Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gly Thr Ala Ser Leu Ile Gly Met Asp Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ala Ser Ala Pro Lys 
        115                 120                 125             


Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Tyr Val Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Pro 
145                 150                 155                 160 


Cys Gly Gly Asn Asn Ile Gly Asp Lys Asn Val Gln Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Asp Gln Ala Pro Val Leu Val Val Tyr Asp Asp Ser Asp Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Lys 
        195                 200                 205             


Ala Ala Leu Thr Ile Ser Gly Val Glu Val Gly Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Gln Val Trp Asp Arg Ser Ser Asp Val Val Val Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val 
                245                 250                 255     


Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp Lys Thr His Thr 
            260                 265                 270         


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
        275                 280                 285             


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
    290                 295                 300                 


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
305                 310                 315                 320 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
                325                 330                 335     


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
            340                 345                 350         


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
        355                 360                 365             


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
    370                 375                 380                 


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
385                 390                 395                 400 


Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
                405                 410                 415     


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
            420                 425                 430         


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
        435                 440                 445             


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
    450                 455                 460                 


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
465                 470                 475                 480 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 


<210>  13
<211>  798
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  13
ccatggccga ggtgcagctg gtggagtctg gggctgaggt gaagaagcct ggggcctcag       60

tgaaggtctc ctgcaaggtt tccggataca ccctcactga attatccatg cactgggtgc      120

gacagactcc tggaaaaggg cttgagtgga tgggaggttt tgatcctgaa gatggtgaaa      180

caatctacgc acagaagttc cagggcagag tcaccatgac cgaggacaca tctacagaca      240

cagcctacat ggagctgagc agcctgagat ctgaggacac ggccgtgtat tactgtgcaa      300

cccaaggata tagtggctac gattactact ttgactactg gggccaggga accctggtca      360

ccgtctcctc agggagtgca tccgccccaa agcttgaaga aggtgaattt tcagaagcac      420

gcgtatcttc tgagctgact caggacccta ttgtgtctgt ggccttggga cagacagtca      480

ggatcgcttg ccaaggagac agcctcagaa cctcttatgc aagctggtac cagcagaagc      540

caggacaggc ccctgtactt gtcatgtacg gtaaaaacaa tcggccctca gggatccccg      600

accgattctc tggctcctac tcagggatct cagcttcctt gaccatcact ggggctcagg      660

cggaagatga ggctgactat tactgttact cccgggagac cactggatac cattatgtct      720

tcggaactgg gaccaaggtc accgtcctag gtcagcccaa ggccaacccc actgtcactc      780

tgttcccacc ctcctctg                                                    798


<210>  14
<211>  496
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  14

Met Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30          


Glu Leu Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gln Gly Tyr Ser Gly Tyr Asp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Ser Glu 
    130                 135                 140                 


Leu Thr Gln Asp Pro Ile Val Ser Val Ala Leu Gly Gln Thr Val Arg 
145                 150                 155                 160 


Ile Ala Cys Gln Gly Asp Ser Leu Arg Thr Ser Tyr Ala Ser Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Met Tyr Gly Lys Asn 
            180                 185                 190         


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Tyr Ser Gly 
        195                 200                 205             


Ile Ser Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Tyr Ser Arg Glu Thr Thr Gly Tyr His Tyr Val Phe 
225                 230                 235                 240 


Gly Thr Gly Thr Lys Val Thr Val Leu Gly Gln Pro Lys Ala Asn Pro 
                245                 250                 255     


Thr Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


<210>  15
<211>  805
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  15
ccatggccca agtccagctg gtacagtctg gagcagaggt gaaaaagccc ggggagtctc       60

tgaggatctc ctgtaagggt tctgaataca gctttaccac ctcctggatc aactgggtgc      120

gccagatgcc cgggaaaggc ctggagtgga tggggaccat tgatcctagt gactcttata      180

ccgactacag cccgtccttc cgaggccacg tcaccatctc agttgacaag tccatcagta      240

ctgcctacct gcagtggagc agcctgaagg cctcagacac cgccgtctat tactgtgcga      300

ctccgtatag cacttctccc gggtccggtt tcgactcctg gggccaggga accctggtca      360

ccgtctcctc agggagtgca tccgccccaa agcttgaaga aggtgaattt tcagaagcac      420

gcgtaaattt tatgctgact cagccccact ctgtgtcggg gtctccgggg aagacggtta      480

ccatctcctg taccgccaac ggtggcagcc ttgccaacaa ctttgtgcag tggtaccagc      540

agcgcccggg cagtgccccc acccctgtta tctatgagga tagtcaaaga ccctctgggg      600

tccctgatcg gttctctggc ttcatcgaca gctcctccaa ctctgcctcc ctcaccatct      660

ctggactgaa gactgaggac gaggctgatt actactgtca gtcttatgat aacaaagatt      720

gggtgttcgg cggagggacc aggctgaccg ttcctgggtc agcccaaggc tgccccctcg      780

gtcactctgt tcccgccctc ctctg                                            805


<210>  16
<211>  498
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  16

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Glu Ser Leu Arg Ile Ser Cys Lys Gly Ser Glu Tyr Ser Phe Thr 
            20                  25                  30          


Thr Ser Trp Ile Asn Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Thr Ile Asp Pro Ser Asp Ser Tyr Thr Asp Tyr Ser Pro 
    50                  55                  60                  


Ser Phe Arg Gly His Val Thr Ile Ser Val Asp Lys Ser Ile Ser Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Pro Tyr Ser Thr Ser Pro Gly Ser Gly Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Asn Phe Met 
    130                 135                 140                 


Leu Thr Gln Pro His Ser Val Ser Gly Ser Pro Gly Lys Thr Val Thr 
145                 150                 155                 160 


Ile Ser Cys Thr Ala Asn Gly Gly Ser Leu Ala Asn Asn Phe Val Gln 
                165                 170                 175     


Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Pro Val Ile Tyr Glu 
            180                 185                 190         


Asp Ser Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Phe Ile 
        195                 200                 205             


Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr 
    210                 215                 220                 


Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Asn Lys Asp Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Arg Leu Thr Val Leu Gly Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  17
<211>  811
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  17
ccatggccca ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag       60

tgaaggtctc ctgcaaggtt tccggataca ccctcactga attatccatg cactgggtgc      120

gccagactcc tggaaaaggg cttgagtgga tgggaggttt tgatcctgaa gatggtgaaa      180

caatctacgc acagaagttc cagggcagag tcaccatgac cgaggacaca tctacagaca      240

cagcctacat ggagctgagc agcctgaggt ctgaggacac ggccgtgtat tactgtgcaa      300

cccaaggata tagtggctac gattactact ttgactactg gggccaggga accctggtca      360

ccgtctcctc agggagtgca tccgccccaa agcttgaaga aggtgaattt tcagaagcac      420

gcgtacagtc tgtgttgacg cagccgccct cagcgtctgg gacccccggg cagagggtca      480

ccatctcttg ttctggaagc agctccaaca tcggaagtaa tgctgtaaac tggtaccagc      540

agctcccagg aacggccccc aaactcctca tctatagtaa taatcaccgg ccctcagggg      600

tccctgaccg attctctggc tccaagtctg gcacctcagc ctccctggcc atcagtggac      660

tccagtctga ggatgaggct gattattact gtgcagcatg ggatgacggc ctgaatggtt      720

gggtgttcgg cggagggacc aagctgaccg tcctaggtca gcccaaggct gccccctcgg      780

tcactctgtt cccaccgtcc tctgcggccg c                                     811


<210>  18
<211>  498
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  18

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30          


Glu Leu Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gln Gly Tyr Ser Gly Tyr Asp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ser Val 
    130                 135                 140                 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Ala Val Asn 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser 
            180                 185                 190         


Asn Asn His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Gly Leu Asn Gly Trp 
225                 230                 235                 240 


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  19
<211>  814
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  19
ccatggccca ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag       60

tgaaggtctc ctgcaaggtt tccggataca ccctcactga attatccatg cactgggtgc      120

gccagactcc tggaaaaggg cttgagtgga tgggaggttt tgatcctgaa gatggtgaaa      180

caatctacgc acagaagttc cagggcagag tcaccatgac cgaggacaca tctacagaca      240

cagcctacat ggagctgagc agcctgaggt ctgaggacac ggccgtgtat tactgtgcaa      300

cccaaggata tagtggctac gattactact ttgactactg gggccaggga accctggtca      360

ccgtctcctc agggagtgca tccgccccaa agcttgaaga aggtgaattt tcagaagcac      420

gcgtacaggc tgtggtgact caggagccat cgttgtcagt gtcccctgga gggacagtca      480

cactcagttg tggattgagc tctggctcag tctcttctac tcattatccc agttggtacc      540

agcagacccc aggccaggcc ccacgtacac tcatctacaa cacaaacatt cgctcttctg      600

gggtccctga ccgattctct ggctccaagt ctggcacctc agcctccctg gccatcagtg      660

ggctccggtc cgaggatgag gctgattatt actgtgcagc atgggatgac agcctgagtg      720

gttgggtgtt cggcggaggg accaagctga ccgtcctagg tcagcccaag gctgccccct      780

cggtcactct gttcccaccc tcctctgcgg ccgc                                  814


<210>  20
<211>  499
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  20

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30          


Glu Leu Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gln Gly Tyr Ser Gly Tyr Asp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ala Val 
    130                 135                 140                 


Val Thr Gln Glu Pro Ser Leu Ser Val Ser Pro Gly Gly Thr Val Thr 
145                 150                 155                 160 


Leu Ser Cys Gly Leu Ser Ser Gly Ser Val Ser Ser Thr His Tyr Pro 
                165                 170                 175     


Ser Trp Tyr Gln Gln Thr Pro Gly Gln Ala Pro Arg Thr Leu Ile Tyr 
            180                 185                 190         


Asn Thr Asn Ile Arg Ser Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly 
225                 230                 235                 240 


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
                245                 250                 255     


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
        275                 280                 285             


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Lys 
            


<210>  21
<211>  811
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  21
ccatggccca ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag       60

tgaaggtctc ctgcaaggtt tccggataca ccctcactga attatccatg cactgggtgc      120

gccagactcc tggaaaaggg cttgagtgga tgggaggttt tgatcctgaa gatggtgaaa      180

caatctacgc acagaagttc cagggcagag tcaccatgac cgaggacaca tctacagaca      240

cagcctacat ggagctgagc agcctgaggt ctgaggacac ggccgtgtat tactgtgcaa      300

cccaaggata tagtggctac gattactact ttgactactg gggccaggga accctggtca      360

ccgtctcctc agggagtgca tccgccccaa agcttgaaga aggtgaattt tcagaagcac      420

gcgtacaggc tgtgctgact cagccaccct cagcgtctgg gacccccggg cagagggtca      480

ccatctcttg ttctgggagc aactccaacg tcgggaggta tactgtaaac tggtaccaac      540

aactcccagg aacggccccc aaactcctca tcaatactaa tgatcggcgg ccctcagggg      600

tccctgaccg attctctggc tccaagtctg gcacctcagc ctccctggcc atcagtggcc      660

tccagtctga ggatgaggct gcttattact gtgcagcctg ggatgacagc cggaatggtt      720

gggcgttcgg cggagggacc aagctgaccg tcctccgtca gcccaaggct gccccctcgg      780

tcactctgtt cccgccctcc tctgcggccg c                                     811


<210>  22
<211>  498
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  22

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30          


Glu Leu Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gln Gly Tyr Ser Gly Tyr Asp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Gln Ala Val 
    130                 135                 140                 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
145                 150                 155                 160 


Ile Ser Cys Ser Gly Ser Asn Ser Asn Val Gly Arg Tyr Thr Val Asn 
                165                 170                 175     


Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Asn Thr 
            180                 185                 190         


Asn Asp Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
        195                 200                 205             


Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp 
    210                 215                 220                 


Glu Ala Ala Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Arg Asn Gly Trp 
225                 230                 235                 240 


Ala Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Arg Gln Pro Lys Ala 
                245                 250                 255     


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp 
            260                 265                 270         


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
        275                 280                 285             


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
    290                 295                 300                 


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
305                 310                 315                 320 


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
                325                 330                 335     


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
            340                 345                 350         


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
        355                 360                 365             


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
    370                 375                 380                 


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
385                 390                 395                 400 


Thr Leu Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu 
                405                 410                 415     


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
            420                 425                 430         


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
        435                 440                 445             


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
    450                 455                 460                 


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
465                 470                 475                 480 


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
                485                 490                 495     


Gly Lys 
        


<210>  23
<211>  805
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  23
ccatggccca ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag       60

tgaaggtctc ctgcaaggtt tccggataca ccctcactga attatccatg cactgggtgc      120

gccagactcc tggaaaaggg cttgagtgga tgggaggttt tgatcctgaa gatggtgaaa      180

caatctacgc acagaagttc cagggcagag tcaccatgac cgaggacaca tctacagaca      240

cagcctacat ggagctgagc agcctgaggt ctgaggacac ggccgtgtat tactgtgcaa      300

cccaaggata tagtggctac gattactact ttgactactg gggccaggga accctggtca      360

ccgtctcctc agggagtgca tccgccccaa agcttgaaga aggtgaattt tcagaagcac      420

gcgtatcttc tgagctgact caggaccctg ctgtgtctgt ggccttggga cagacagtca      480

ggatcacatg ccaaggagac agcctcagaa actattatgc aagctggtac cagcagaagc      540

caggacaggc ccccgtagtt gtcatctatg gtaaaaacaa ccggccctca gggatcccag      600

accgattctc tggctccagc tcaggaaaca cagcttcctt gaccatcact ggggctcaag      660

cggaagatga ggctgactat tactgtaact cccgggacag cagtggtaac catgtggtat      720

tcggcggagg gaccaagctg accgtcctag gtcagtccaa ggctgccccc tcggtcactc      780

tgttcccacc ctcctctgcg gccgc                                            805


<210>  24
<211>  496
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  24

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30          


Glu Leu Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gln Gly Tyr Ser Gly Tyr Asp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Ser Glu 
    130                 135                 140                 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
145                 150                 155                 160 


Ile Thr Cys Gln Gly Asp Ser Leu Arg Asn Tyr Tyr Ala Ser Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr Gly Lys Asn 
            180                 185                 190         


Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His Val Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Ser Lys Ala Ala Pro 
                245                 250                 255     


Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp Lys Thr 
            260                 265                 270         


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
        275                 280                 285             


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
    290                 295                 300                 


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
305                 310                 315                 320 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
                325                 330                 335     


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
            340                 345                 350         


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
        355                 360                 365             


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
    370                 375                 380                 


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
385                 390                 395                 400 


Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr Cys 
                405                 410                 415     


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
            420                 425                 430         


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
        435                 440                 445             


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
    450                 455                 460                 


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
465                 470                 475                 480 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                485                 490                 495     


<210>  25
<211>  808
<212>  DNA
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  25
ccatggccca ggtccagctg gtgcagtctg gggctgaggt gaagaagcct ggggcctcag       60

tgaaggtctc ctgcaaggtt tccggataca ccctcactga attatccatg cactgggtgc      120

gccagactcc tggaaaaggg cttgagtgga tgggaggttt tgatcctgaa gatggtgaaa      180

caatctacgc acagaagttc cagggcagag tcaccatgac cgaggacaca tctacagaca      240

cagcctacat ggagctgagc agcctgaggt ctgaggacac ggccgtgtat tactgtgcaa      300

cccaaggata tagtggctac gattactact ttgactactg gggccaggga accctggtca      360

ccgtctcctc agggagtgca tccgccccaa agcttgaaga aggtgaattt tcagaagcac      420

gcgtatcttc tgagctgact caggaccctg ctgtgtctgt ggccttggga cagacagtca      480

ggatcacatg ccaaggagac agcctcagaa gctattatgc aagctggtac cagcagaagc      540

caggacaggc ccctgtagtt gtcatctatg gtaaaaacga ccggccctca gggatcccag      600

accgattctc tggctccagc tcaggaaaca cagcttcctt gaccatcact ggggctcagg      660

cggaagatga ggctgactat tactgtaact cccgggacag cagtggtaac catcatgtgg      720

tattcggcgg agggaccaag ctgaccgtcc taggtcagcc caaggctgcc ccctcggtca      780

ctctgttccc accgtcctct gcggccgc                                         808


<210>  26
<211>  497
<212>  PRT
<213>  Sequncia artificial

<220>
<223>  anticorpo

<400>  26

Met Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro 
1               5                   10                  15      


Gly Ala Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr 
            20                  25                  30          


Glu Leu Ser Met His Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Met Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln 
    50                  55                  60                  


Lys Phe Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr 
65                  70                  75                  80  


Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Thr Gln Gly Tyr Ser Gly Tyr Asp Tyr Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Ala Ser Ala 
        115                 120                 125             


Pro Lys Leu Glu Glu Gly Glu Phe Ser Glu Ala Arg Val Ser Ser Glu 
    130                 135                 140                 


Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly Gln Thr Val Arg 
145                 150                 155                 160 


Ile Thr Cys Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Val Val Val Ile Tyr Gly Lys Asn 
            180                 185                 190         


Asp Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Ser Ser Gly 
        195                 200                 205             


Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala Glu Asp Glu Ala 
    210                 215                 220                 


Asp Tyr Tyr Cys Asn Ser Arg Asp Ser Ser Gly Asn His His Val Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
                245                 250                 255     


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Ala Ala Ala Ser Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Arg Glu Glu Val Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys 
    


