                               SEQUENCE LISTING

<110> UNIVERSITY OF SOUTHERN CALIFORNIA
 
<120> SITE-SPECIFIC ANTIBODY-DRUG CONJUGATES BY ADP-RIBOSYL CYCLASES

<130> 530.014WO1

<140> PCT/US2021/031576
<141> 2020-05-10

<150> 63/021,975
<151> 2020-05-08

<160> 81    

<170> PatentIn version 3.5

<210> 1
<211> 300
<212> PRT
<213> Homo sapiens

<400> 1
Met Ala Asn Cys Glu Phe Ser Pro Val Ser Gly Asp Lys Pro Cys Cys 
1               5                   10                  15      


Arg Leu Ser Arg Arg Ala Gln Leu Cys Leu Gly Val Ser Ile Leu Val 
            20                  25                  30          


Leu Ile Leu Val Val Val Leu Ala Val Val Val Pro Arg Trp Arg Gln 
        35                  40                  45              


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
    50                  55                  60                  


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
65                  70                  75                  80  


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
                85                  90                  95      


His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
            100                 105                 110         


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
        115                 120                 125             


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
    130                 135                 140                 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
145                 150                 155                 160 


Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
                165                 170                 175     


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
            180                 185                 190         


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
        195                 200                 205             


Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser Thr Phe Gly Ser 
    210                 215                 220                 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
225                 230                 235                 240 


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
                245                 250                 255     


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
            260                 265                 270         


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
        275                 280                 285             


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
    290                 295                 300 


<210> 2
<211> 256
<212> PRT
<213> Homo sapiens

<400> 2
Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro 
1               5                   10                  15      


Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu 
            20                  25                  30          


Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 
        35                  40                  45              


Phe Ile Ser Lys His Pro Cys Asn Ile Thr Glu Glu Asp Tyr Gln Pro 
    50                  55                  60                  


Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu 
65                  70                  75                  80  


Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 
                85                  90                  95      


Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp 
            100                 105                 110         


Leu Thr Trp Cys Gly Glu Phe Asn Thr Ser Lys Ile Asn Tyr Gln Ser 
        115                 120                 125             


Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 
    130                 135                 140                 


Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val 
145                 150                 155                 160 


His Val Met Leu Asn Gly Ser Arg Ser Lys Ile Phe Asp Lys Asn Ser 
                165                 170                 175     


Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 
            180                 185                 190         


Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 
        195                 200                 205             


Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 
    210                 215                 220                 


Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 
225                 230                 235                 240 


Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
                245                 250                 255     


<210> 3
<211> 256
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro 
1               5                   10                  15      


Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu 
            20                  25                  30          


Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 
        35                  40                  45              


Phe Ile Ser Lys His Pro Cys Asp Ile Thr Glu Glu Asp Tyr Gln Pro 
    50                  55                  60                  


Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu 
65                  70                  75                  80  


Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 
                85                  90                  95      


Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp 
            100                 105                 110         


Leu Thr Trp Cys Gly Glu Phe Ala Thr Ser Lys Ile Asn Tyr Gln Ser 
        115                 120                 125             


Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 
    130                 135                 140                 


Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val 
145                 150                 155                 160 


His Val Met Leu Asp Gly Ser Arg Ser Lys Ile Phe Asp Lys Asp Ser 
                165                 170                 175     


Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 
            180                 185                 190         


Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 
        195                 200                 205             


Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 
    210                 215                 220                 


Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 
225                 230                 235                 240 


Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
                245                 250                 255     


<210> 4
<211> 318
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Ala Gln Gly Cys Ala Ala Ser Arg Leu Leu Gln Leu Leu Leu 
1               5                   10                  15      


Gln Leu Leu Leu Leu Leu Leu Leu Leu Ala Ala Gly Gly Ala Arg Ala 
            20                  25                  30          


Arg Trp Arg Gly Glu Gly Thr Ser Ala His Leu Arg Asp Ile Phe Leu 
        35                  40                  45              


Gly Arg Cys Ala Glu Tyr Arg Ala Leu Leu Ser Pro Glu Gln Arg Asn 
    50                  55                  60                  


Lys Asn Cys Thr Ala Ile Trp Glu Ala Phe Lys Val Ala Leu Asp Lys 
65                  70                  75                  80  


Asp Pro Cys Ser Val Leu Pro Ser Asp Tyr Asp Leu Phe Ile Asn Leu 
                85                  90                  95      


Ser Arg His Ser Ile Pro Arg Asp Lys Ser Leu Phe Trp Glu Asn Ser 
            100                 105                 110         


His Leu Leu Val Asn Ser Phe Ala Asp Asn Thr Arg Arg Phe Met Pro 
        115                 120                 125             


Leu Ser Asp Val Leu Tyr Gly Arg Val Ala Asp Phe Leu Ser Trp Cys 
    130                 135                 140                 


Arg Gln Lys Asn Asp Ser Gly Leu Asp Tyr Gln Ser Cys Pro Thr Ser 
145                 150                 155                 160 


Glu Asp Cys Glu Asn Asn Pro Val Asp Ser Phe Trp Lys Arg Ala Ser 
                165                 170                 175     


Ile Gln Tyr Ser Lys Asp Ser Ser Gly Val Ile His Val Met Leu Asn 
            180                 185                 190         


Gly Ser Glu Pro Thr Gly Ala Tyr Pro Ile Lys Gly Phe Phe Ala Asp 
        195                 200                 205             


Tyr Glu Ile Pro Asn Leu Gln Lys Glu Lys Ile Thr Arg Ile Glu Ile 
    210                 215                 220                 


Trp Val Met His Glu Ile Gly Gly Pro Asn Val Glu Ser Cys Gly Glu 
225                 230                 235                 240 


Gly Ser Met Lys Val Leu Glu Lys Arg Leu Lys Asp Met Gly Phe Gln 
                245                 250                 255     


Tyr Ser Cys Ile Asn Asp Tyr Arg Pro Val Lys Leu Leu Gln Cys Val 
            260                 265                 270         


Asp His Ser Thr His Pro Asp Cys Ala Leu Lys Ser Ala Ala Ala Ala 
        275                 280                 285             


Thr Gln Arg Lys Ala Pro Ser Leu Tyr Thr Glu Gln Arg Ala Gly Leu 
    290                 295                 300                 


Ile Ile Pro Leu Phe Leu Val Leu Ala Ser Arg Thr Gln Leu 
305                 310                 315             


<210> 5
<211> 263
<212> PRT
<213> Homo sapiens

<400> 5
Met Ser Glu Glu Val Thr Tyr Ala Asp Gln Phe Gln Asn Ser Ser Glu 
1               5                   10                  15      


Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro Pro 
            20                  25                  30          


Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu Leu 
        35                  40                  45              


Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe His 
    50                  55                  60                  


Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn Ile 
65                  70                  75                  80  


Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn Met 
                85                  90                  95      


Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Gln Thr Ile Ala 
            100                 105                 110         


Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His Lys Cys 
        115                 120                 125             


Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys Tyr Phe 
    130                 135                 140                 


Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala Cys Ala 
145                 150                 155                 160 


Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala Leu Glu 
                165                 170                 175     


Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly Leu Ser 
            180                 185                 190         


Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile Ile Asn 
        195                 200                 205             


Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn Met Tyr 
    210                 215                 220                 


Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys Thr Tyr 
225                 230                 235                 240 


Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln Leu Gly 
                245                 250                 255     


Ser Thr Tyr Phe Arg Glu Ala 
            260             


<210> 6
<211> 215
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 6
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Asn Val Ile Ser Ser 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210> 7
<211> 645
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
gagaacgtgc tcacccaatc ccccgccatt atgtccgcct ccccaggcga aaaggtgaca       60

atgacctgca gggccagctc caacgtgatc agctcttacg tgcactggta ccagcaacgg      120

tccggcgcct cccctaagct gtggatctat agcacaagca acctggcttc cggcgtgcct      180

gcacggttca gcggaagcgg aagcggaaca agttactccc tcaccatttc tagcgttgaa      240

gccgaggatg ccgctacata ctattgtcaa cagtacagcg gataccccct gaccttcgga      300

gccggcacaa aactggagct caagagagca gctgcagctc ccagcgtgtt catttttcct      360

ccctccgacg aacaactgaa aagcggaaca gcctctgtcg tttgcctgtt gaacaatttc      420

taccctaggg aggccaaggt ccagtggaaa gtggataacg ctctgcaaag cggaaattct      480

caggaaagcg ttaccgaaca ggattctaag gactctacat actctctgtc tagcacactc      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgtcct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210> 8
<211> 453
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 8
Asp Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Asp Tyr Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Arg Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210> 9
<211> 1359
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 9
gacatccagc tgcaggagag cggccccggc ctggtgaagc ccagccagag cctgagcctg       60

acctgcagcg tgaccggcta cagcatcacc agcgcctatt actggaactg gatccggcag      120

ttccccggca acaagctgga gtggatgggc tacatcagct acgacggccg gaacaactac      180

aacccaagcc tgaagaaccg gatcagcatc acccgggaca ccagcaagaa ccagtttttc      240

ctgaagctga acagcgtgac cacagaggac accgccacct attactgcgc caaggaggga      300

gactacgacg tgggcaacta ctacgccatg gactactggg gccagggcac cagcgtgacc      360

gtgtctagcg cccggaccaa gggccccagc gtgttccccc tggcccccag ctctaagagc      420

accagcggcg gaaccgccgc tctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgagct ggaacagcgg cgccctgacc agcggcgtgc acaccttccc cgccgtgctg      540

cagagctctg gcctgtacag cctgagcagc gtggttaccg tgcccagttc ttccctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaaa      660

gtggaaccca aatcttgcga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210> 10
<211> 476
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Glu Asn Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Asn Val Ile Ser Ser 
            20                  25                  30          


Tyr Val His Trp Tyr Gln Gln Arg Ser Gly Ala Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Val Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Gly Tyr Pro 
                85                  90                  95      


Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Ala Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Arg Trp Arg Gln 
    210                 215                 220                 


Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu 
225                 230                 235                 240 


Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val 
                245                 250                 255     


Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys 
            260                 265                 270         


His Pro Cys Asp Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu 
        275                 280                 285             


Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile 
    290                 295                 300                 


Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr 
305                 310                 315                 320 


Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys 
                325                 330                 335     


Gly Glu Phe Ala Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp 
            340                 345                 350         


Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val 
        355                 360                 365             


Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu 
    370                 375                 380                 


Asp Gly Ser Arg Ser Lys Ile Phe Asp Lys Asp Ser Thr Phe Gly Ser 
385                 390                 395                 400 


Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala 
                405                 410                 415     


Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp 
            420                 425                 430         


Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln 
        435                 440                 445             


Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val 
    450                 455                 460                 


Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
465                 470                 475     


<210> 11
<211> 1428
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 11
gagaacgtgc tcacccaatc ccccgccatt atgtccgcct ccccaggcga aaaggtgaca       60

atgacctgca gggccagctc caacgtgatc agctcttacg tgcactggta ccagcaacgg      120

tccggcgcct cccctaagct gtggatctat agcacaagca acctggcttc cggcgtgcct      180

gcacggttca gcggaagcgg aagcggaaca agttactccc tcaccatttc tagcgttgaa      240

gccgaggatg ccgctacata ctattgtcaa cagtacagcg gataccccct gaccttcgga      300

gccggcacaa aactggagct caagagagca gctgcagctc ccagcgtgtt catttttcct      360

ccctccgacg aacaactgaa aagcggaaca gcctctgtcg tttgcctgtt gaacaatttc      420

taccctaggg aggccaaggt ccagtggaaa gtggataacg ctctgcaaag cggaaattct      480

caggaaagcg ttaccgaaca ggattctaag gactctacat actctctgtc tagcacactc      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgtcct cgcccgtcac aaagagcttc aacaggggag agtgtggggg tggcggaagc      660

agatggaggc aacaatggtc aggccccgga acaacaaaac gatttccaga aacggtcctg      720

gcacggtgtg tgaaatatac agaaatacat cccgaaatgc gccatgttga ttgccaatct      780

gtatgggatg ctttcaaagg cgcattcatt agcaagcacc catgcgatat aaccgaggaa      840

gactaccagc ccctgatgaa acttggcaca caaactgtcc cgtgcaataa aatcctgctg      900

tggtcacgga tcaaagacct tgcccatcag tttactcagg ttcagcgaga tatgttcaca      960

cttgaggata cgttgttggg gtacctcgca gatgatctga cctggtgtgg ggagttcgcc     1020

acgtcaaaga taaattacca aagttgtcct gattggagaa aagactgcag taataaccct     1080

gtctctgttt tctggaaaac tgtaagccgc aggttcgctg aagcagcctg cgatgtggtt     1140

cacgttatgc tggatggatc tcggagcaag attttcgata aagattccac cttcggaagt     1200

gttgaagtac ataacctcca acccgaaaaa gtgcagacac ttgaggcatg ggttattcat     1260

ggaggccgag aggacagccg ggacctgtgc caggacccta ccataaagga acttgagtct     1320

attatctcaa agcgaaatat tcagttttcc tgcaagaata tttatcggcc agataaattt     1380

cttcaatgcg tcaaaaaccc agaggatagt tcatgtacta gtgagatc                  1428


<210> 12
<211> 714
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Asp Ile Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Asp Gly Arg Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Gly Asp Tyr Asp Val Gly Asn Tyr Tyr Ala Met Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Arg Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu 
225                 230                 235                 240 


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Arg Trp Arg Gln Gln Trp 
    450                 455                 460                 


Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu Ala Arg 
465                 470                 475                 480 


Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val Asp Cys 
                485                 490                 495     


Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys His Pro 
            500                 505                 510         


Cys Asp Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu Gly Thr 
        515                 520                 525             


Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile Lys Asp 
    530                 535                 540                 


Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr Leu Glu 
545                 550                 555                 560 


Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys Gly Glu 
                565                 570                 575     


Phe Ala Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp Arg Lys 
            580                 585                 590         


Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val Ser Arg 
        595                 600                 605             


Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu Asp Gly 
    610                 615                 620                 


Ser Arg Ser Lys Ile Phe Asp Lys Asp Ser Thr Phe Gly Ser Val Glu 
625                 630                 635                 640 


Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala Trp Val 
                645                 650                 655     


Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp Pro Thr 
            660                 665                 670         


Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln Phe Ser 
        675                 680                 685             


Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val Lys Asn 
    690                 695                 700                 


Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
705                 710                 


<210> 13
<211> 2142
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
gacatccagc tgcaggagag cggccccggc ctggtgaagc ccagccagag cctgagcctg       60

acctgcagcg tgaccggcta cagcatcacc agcgcctatt actggaactg gatccggcag      120

ttccccggca acaagctgga gtggatgggc tacatcagct acgacggccg gaacaactac      180

aacccaagcc tgaagaaccg gatcagcatc acccgggaca ccagcaagaa ccagtttttc      240

ctgaagctga acagcgtgac cacagaggac accgccacct attactgcgc caaggaggga      300

gactacgacg tgggcaacta ctacgccatg gactactggg gccagggcac cagcgtgacc      360

gtgtctagcg cccggaccaa gggccccagc gtgttccccc tggcccccag ctctaagagc      420

accagcggcg gaaccgccgc tctgggctgc ctggtgaagg actacttccc cgagcccgtg      480

accgtgagct ggaacagcgg cgccctgacc agcggcgtgc acaccttccc cgccgtgctg      540

cagagctctg gcctgtacag cctgagcagc gtggttaccg tgcccagttc ttccctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagaaa      660

gtggaaccca aatcttgcga caaaactcac acatgcccac cgtgcccagc acctgaactc      720

ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaag ggggtggcgg aagcagatgg     1380

aggcaacaat ggtcaggccc cggaacaaca aaacgatttc cagaaacggt cctggcacgg     1440

tgtgtgaaat atacagaaat acatcccgaa atgcgccatg ttgattgcca atctgtatgg     1500

gatgctttca aaggcgcatt cattagcaag cacccatgcg atataaccga ggaagactac     1560

cagcccctga tgaaacttgg cacacaaact gtcccgtgca ataaaatcct gctgtggtca     1620

cggatcaaag accttgccca tcagtttact caggttcagc gagatatgtt cacacttgag     1680

gatacgttgt tggggtacct cgcagatgat ctgacctggt gtggggagtt cgccacgtca     1740

aagataaatt accaaagttg tcctgattgg agaaaagact gcagtaataa ccctgtctct     1800

gttttctgga aaactgtaag ccgcaggttc gctgaagcag cctgcgatgt ggttcacgtt     1860

atgctggatg gatctcggag caagattttc gataaagatt ccaccttcgg aagtgttgaa     1920

gtacataacc tccaacccga aaaagtgcag acacttgagg catgggttat tcatggaggc     1980

cgagaggaca gccgggacct gtgccaggac cctaccataa aggaacttga gtctattatc     2040

tcaaagcgaa atattcagtt ttcctgcaag aatatttatc ggccagataa atttcttcaa     2100

tgcgtcaaaa acccagagga tagttcatgt actagtgaga tc                        2142


<210> 14
<211> 450
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210> 15
<211> 214
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210> 16
<211> 475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Arg Trp Arg Gln Gln Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro 
1               5                   10                  15      


Glu Thr Val Leu Ala Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu 
            20                  25                  30          


Met Arg His Val Asp Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala 
        35                  40                  45              


Phe Ile Ser Lys His Pro Cys Asp Ile Thr Glu Glu Asp Tyr Gln Pro 
    50                  55                  60                  


Leu Met Lys Leu Gly Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu 
65                  70                  75                  80  


Trp Ser Arg Ile Lys Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg 
                85                  90                  95      


Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp 
            100                 105                 110         


Leu Thr Trp Cys Gly Glu Phe Ala Thr Ser Lys Ile Asn Tyr Gln Ser 
        115                 120                 125             


Cys Pro Asp Trp Arg Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe 
    130                 135                 140                 


Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val 
145                 150                 155                 160 


His Val Met Leu Asp Gly Ser Arg Ser Lys Ile Phe Asp Lys Asp Ser 
                165                 170                 175     


Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys Val Gln 
            180                 185                 190         


Thr Leu Glu Ala Trp Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp 
        195                 200                 205             


Leu Cys Gln Asp Pro Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys 
    210                 215                 220                 


Arg Asn Ile Gln Phe Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe 
225                 230                 235                 240 


Leu Gln Cys Val Lys Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
                245                 250                 255     


Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
            260                 265                 270         


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln 
        275                 280                 285             


Asp Val Asn Thr Ala Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala 
    290                 295                 300                 


Pro Lys Leu Leu Ile Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro 
305                 310                 315                 320 


Ser Arg Phe Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                325                 330                 335     


Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His 
            340                 345                 350         


Tyr Thr Thr Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
        355                 360                 365             


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
    370                 375                 380                 


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
385                 390                 395                 400 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
                405                 410                 415     


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
            420                 425                 430         


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
        435                 440                 445             


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
    450                 455                 460                 


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
465                 470                 475 


<210> 17
<211> 475
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys Gly Gly Gly Gly Ser Arg Trp Arg Gln Gln 
    210                 215                 220                 


Trp Ser Gly Pro Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu Ala 
225                 230                 235                 240 


Arg Cys Val Lys Tyr Thr Glu Ile His Pro Glu Met Arg His Val Asp 
                245                 250                 255     


Cys Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys His 
            260                 265                 270         


Pro Cys Asp Ile Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu Gly 
        275                 280                 285             


Thr Gln Thr Val Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile Lys 
    290                 295                 300                 


Asp Leu Ala His Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr Leu 
305                 310                 315                 320 


Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys Gly 
                325                 330                 335     


Glu Phe Ala Thr Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp Arg 
            340                 345                 350         


Lys Asp Cys Ser Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val Ser 
        355                 360                 365             


Arg Arg Phe Ala Glu Ala Ala Cys Asp Val Val His Val Met Leu Asp 
    370                 375                 380                 


Gly Ser Arg Ser Lys Ile Phe Asp Lys Asp Ser Thr Phe Gly Ser Val 
385                 390                 395                 400 


Glu Val His Asn Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala Trp 
                405                 410                 415     


Val Ile His Gly Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp Pro 
            420                 425                 430         


Thr Ile Lys Glu Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln Phe 
        435                 440                 445             


Ser Cys Lys Asn Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val Lys 
    450                 455                 460                 


Asn Pro Glu Asp Ser Ser Cys Thr Ser Glu Ile 
465                 470                 475 


<210> 18
<211> 711
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys Gly Gly Gly Gly Ser Arg Trp Arg Gln Gln Trp Ser Gly Pro 
    450                 455                 460                 


Gly Thr Thr Lys Arg Phe Pro Glu Thr Val Leu Ala Arg Cys Val Lys 
465                 470                 475                 480 


Tyr Thr Glu Ile His Pro Glu Met Arg His Val Asp Cys Gln Ser Val 
                485                 490                 495     


Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys His Pro Cys Asp Ile 
            500                 505                 510         


Thr Glu Glu Asp Tyr Gln Pro Leu Met Lys Leu Gly Thr Gln Thr Val 
        515                 520                 525             


Pro Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile Lys Asp Leu Ala His 
    530                 535                 540                 


Gln Phe Thr Gln Val Gln Arg Asp Met Phe Thr Leu Glu Asp Thr Leu 
545                 550                 555                 560 


Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp Cys Gly Glu Phe Ala Thr 
                565                 570                 575     


Ser Lys Ile Asn Tyr Gln Ser Cys Pro Asp Trp Arg Lys Asp Cys Ser 
            580                 585                 590         


Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala 
        595                 600                 605             


Glu Ala Ala Cys Asp Val Val His Val Met Leu Asp Gly Ser Arg Ser 
    610                 615                 620                 


Lys Ile Phe Asp Lys Asp Ser Thr Phe Gly Ser Val Glu Val His Asn 
625                 630                 635                 640 


Leu Gln Pro Glu Lys Val Gln Thr Leu Glu Ala Trp Val Ile His Gly 
                645                 650                 655     


Gly Arg Glu Asp Ser Arg Asp Leu Cys Gln Asp Pro Thr Ile Lys Glu 
            660                 665                 670         


Leu Glu Ser Ile Ile Ser Lys Arg Asn Ile Gln Phe Ser Cys Lys Asn 
        675                 680                 685             


Ile Tyr Arg Pro Asp Lys Phe Leu Gln Cys Val Lys Asn Pro Glu Asp 
    690                 695                 700                 


Ser Ser Cys Thr Ser Glu Ile 
705                 710     


<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(20) 
<223> This sequence may encompass 1-5 "Gly Gly Gly Ser"
      repeating units

<400> 19
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 20
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(25) 
<223> This sequence may encompass 1-5 "Gly Gly Gly Gly Ser"
      repeating units

<400> 20
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 21
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 21
Gly Gly Gly Gly Ser 
1               5   


<210> 22
<211> 34
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
tcacgaattc gagatggagg caacaatggt cagg                                   34


<210> 23
<211> 41
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
cgccaccccc gatctcacta gtacatgaac tatcctctgg g                           41


<210> 24
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tgagatcggg ggtggcggaa gcgacatcca gatgacccag tctcc                       45


<210> 25
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
cagctagcac ttatcaacac tctccc                                            26


<210> 26
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
gggggtggcg gaagcagatg gaggcaacaa tggtcagg                               38


<210> 27
<211> 50
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
ccagctagca cttatcagat ctcactagta catgaactat cctctgggtt                  50


<210> 28
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
cacgaattcg gaggtgcagc tg                                                22


<210> 29
<211> 37
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
gcttccgcca ccccctttac ccggagacag ggagagg                                37


<210> 30
<211> 43
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ttcggaagtg ttcaggtaca taacctccaa cccgaaaaag tgc                         43


<210> 31
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
ggaggttatg tacctgaaca cttccgaagg tggaatcttt atcga                       45


<210> 32
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
cacgaattcg atcgagatga agaagatgaa caaac                                  35


<210> 33
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
ccagctagca ctcactaatg atgatggtg                                         29


<210> 34
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 34
cacgaattcg gagaacgtgc tcacccaatc ccc                                    33


<210> 35
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 35
ccagctagca cttatcaaca ctctcccctg ttgaagctct ttgtg                       45


<210> 36
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 36
cacgaattcg gacatccagc tgcaggagag cg                                     32


<210> 37
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 37
cgcaagattt gggttccact ttcttgtcca ccttggtgtt gctg                        44


<210> 38
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 38
ggtggacaag aaagtggaac ccaaatcttg cgacaaaact cacacatg                    48


<210> 39
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 39
ccagctagca cttatcattt acccggagac agggagaggc                             40


<210> 40
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 40
gtcacgaatt cggagaacgt gctc                                              24


<210> 41
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 41
cgccaccccc acactctccc ctgttgaagc tctttg                                 36


<210> 42
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 42
ggagagtgtg ggggtggcgg aagc                                              24


<210> 43
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 43
ctggccagct agcacttatc agatctc                                           27


<210> 44
<211> 32
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 44
cacgaattcg gacatccagc tgcaggagag cg                                     32


<210> 45
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 45
cgcaagattt gggttccact ttcttgtcca ccttggtgtt gctg                        44


<210> 46
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 46
ggtggacaag aaagtggaac ccaaatcttg cgacaaaact cacacatg                    48


<210> 47
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 47
ctggccagct agcacttatc agatctc                                           27


<210> 48
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
1               5                   10                  15  


<210> 49
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Val Ser Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala 
1               5                   10                  15  


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Asp Val Val His Val Met Leu Asp Gly Ser Arg Ser Lys Ile Phe 
1               5                   10                  15  


<210> 51
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Asn Pro Val Ser Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala 
1               5                   10                  15  


<210> 52
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Arg Asp Met Phe Thr Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala 
1               5                   10                  15  


<210> 53
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile 
1               5                   10                  15  


<210> 54
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
1               5                   10                  15  


<210> 55
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
1               5                   10                  15  


<210> 56
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
1               5                   10                  15  


<210> 57
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
1               5                   10                  15  


<210> 58
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
1               5                   10                  15  


<210> 59
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 59
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
1               5                   10                  15  


<210> 60
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
1               5                   10                  15  


<210> 61
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Asn Asn Pro Val Ser Val Phe Trp Lys Thr Val Ser Arg Arg Phe 
1               5                   10                  15  


<210> 62
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Cys Asn Lys Ile Leu Leu Trp Ser Arg Ile Lys Asp Leu Ala His 
1               5                   10                  15  


<210> 63
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 63
Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
1               5                   10                  15  


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 64
Asn Lys Ile Leu Leu Trp Ser Arg Ile Lys Asp Leu Ala His Gln 
1               5                   10                  15  


<210> 65
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 65
Gln Ser Val Trp Asp Ala Phe Lys Gly Ala Phe Ile Ser Lys His 
1               5                   10                  15  


<210> 66
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 66
Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala Cys 
1               5                   10                  15  


<210> 67
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 67
Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
1               5                   10                  15  


<210> 68
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 68
Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
1               5                   10                  15  


<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 69
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
1               5                   10                  15  


<210> 70
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
1               5                   10                  15  


<210> 71
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 71
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 
1               5                   10                  15  


<210> 72
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 72
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
1               5                   10                  15  


<210> 73
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 73
Leu Glu Asp Thr Leu Leu Gly Tyr Leu Ala Asp Asp Leu Thr Trp 
1               5                   10                  15  


<210> 74
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 74
Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
1               5                   10                  15  


<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 75
Ser Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala Glu Ala Ala 
1               5                   10                  15  


<210> 76
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 76
Pro Val Ser Val Phe Trp Lys Thr Val Ser Arg Arg Phe Ala Glu 
1               5                   10                  15  


<210> 77
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 77
His His His His His His 
1               5       


<210> 78
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(15) 
<223> This sequence may encompass 0-5 "Gly Gly Ser"
      repeating units

<400> 78
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
1               5                   10                  15  


<210> 79
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(20) 
<223> This sequence may encompass 0-5 "Gly Gly Gly Ser"
      repeating units

<400> 79
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 80
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> SITE
<222> (1)..(25) 
<223> This sequence may encompass 0-5 "Gly Gly Gly Gly Ser"
      repeating units

<400> 80
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 81
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Asp Ser Thr Phe Gly Ser Val Glu Val His Asn Leu Gln Pro Glu Lys 
1               5                   10                  15      

