                         SEQUENCE LISTING

<110>  ALPINE IMMUNE SCIENCES, INC.
 
<120>  APRIL AND BAFF INHIBITORY IMMUNOMODULATORY PROTEINS WITH AND 
       WITHOUT A T CELL INHIBITORY PROTEIN AND METHODS OF USE THEREOF

<130>  761612002340

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150> 63/022,373
<151> 2020-05-08

<150> 63/034,361
<151> 2020-06-03

<150> 63/080,643
<151> 2020-09-18

<160>  824   

<170>  PatentIn version 3.5

<210>  1
<211>  126
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  CTLA-4 ECD

<400>  1

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  2
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 ECD

<400>  2

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln 
        115                 120                 125         


<210>  3
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/Y105L ECD

<400>  3

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  4
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98R/N110K ECD

<400>  4

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  5
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T ECD

<400>  5

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  6
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P ECD

<400>  6

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  7
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/Y105L ECD

<400>  7

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  8
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/Y105L ECD

<400>  8

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  9
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P ECD

<400>  9

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  10
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98R/N110K ECD

<400>  10

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  11
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/M99L/Y105L ECD

<400>  11

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  12
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/Q82H/L98Q/M99L/Y105L ECD

<400>  12

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  13
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/M99L/Y105L ECD

<400>  13

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  14
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S14N/R16C/I18T/M56K/T61A/L63P/A86T/M99L ECD

<400>  14

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Asn Ser Cys 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Ala Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Thr Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  15
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S27P/M56K/L63P/S72G/S73R/T89A/M99L/Y105L/I117M ECD

<400>  15

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Pro Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Arg Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Met Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  16
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56K/L63P/N75D/V96I/M99L/Y105L/L106I ECD

<400>  16

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asp Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  17
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/Y105L ECD

<400>  17

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  18
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L/I117M ECD

<400>  18

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Met Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  19
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/M99L/Y105L/L106I/I117L ECD

<400>  19

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  20
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/Y105L/L106I/I117L ECD

<400>  20

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  21
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/V116A ECD

<400>  21

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Ala Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  22
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L98Q/M99L/Y105L ECD

<400>  22

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  23
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T37S/M56V/L98Q/Y105L ECD

<400>  23

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Ser Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  24
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/Y54F/M56K/M99L/Y105L ECD

<400>  24

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  25
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/I18T/A26T/M55T/T69S/S72G/M99L/Y105L ECD

<400>  25

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ser Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  26
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22I/L63P/L98Q/Y105L/I117M ECD

<400>  26

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Ile Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Met Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  27
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  27

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  28
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/A42T/L98Q/Y105L ECD

<400>  28

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  29
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/E97Q/M99L/Y105F ECD

<400>  29

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Gln Leu Leu Tyr Pro Pro Pro Tyr Phe Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  30
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/S72G/L98Q/M99L/Y105L ECD

<400>  30

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  31
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16C/G29W/E33V/M55T/L63P/L98Q/Y105L ECD

<400>  31

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Cys 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  32
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/Y105L/L106I ECD

<400>  32

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  33
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56L/L63P/L98Q/Y105L/L106I/I117L ECD

<400>  33

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Leu Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  34
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S15P/I18V/M56T/L98Q/M99L/Y105L ECD

<400>  34

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Pro Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  35
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29W/L63P/L98Q/Y105L ECD

<400>  35

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  36
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/Q82H/L98Q/M99L/Y105L ECD

<400>  36

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  37
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L/L106I/I117T ECD

<400>  37

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Thr Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  38
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L/L106I/Y115N ECD

<400>  38

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Asn Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  39
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/L63P/T71I/M99L/Y105L ECD

<400>  39

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Ile Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  40
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/M56K/L63P/L98Q/Y105L ECD

<400>  40

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  41
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/Q82R/L98Q/Y105L ECD

<400>  41

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  42
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/M55T/E59D/L63P/M99L ECD

<400>  42

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Asp Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  43
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/Y105L/I108V ECD

<400>  43

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  44
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  44

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  45
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T61A/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  45

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Ala Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  46
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V38I/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  46

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Ile Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  47
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/I93L/L98Q/M99L/Y105L ECD

<400>  47

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Leu Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  48
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12I/M55T/M56V/I67T/M99L/L106R/I108F ECD

<400>  48

Lys Ala Met His Val Ala Gln Pro Ala Val Val Ile Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Thr Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Arg Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  49
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/A26T/L63H/T89A/L98Q/M99L/Y105L ECD

<400>  49

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Asn Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe His Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  50
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/E48R/L63P/T69S/L98Q/Y105L/N110Y ECD

<400>  50

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Arg 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ser Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Tyr Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  51
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/L63P/S72T/M87T/L98Q/Y105L/N110S ECD

<400>  51

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Asn Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Thr Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Ser Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  52
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M56T/L63P/L98Q/Y105L/L106I/I117L ECD

<400>  52

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  53
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/M87T/L98Q/M99L/Y105L ECD

<400>  53

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  54
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/D64N/L98Q/M99L/Y105L ECD

<400>  54

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asn 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  55
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/M87K/L98Q/M99L/Y105L ECD

<400>  55

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  56
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V ECD

<400>  56

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  57
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/K95R ECD

<400>  57

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Arg Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  58
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q ECD

<400>  58

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  59
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L ECD

<400>  59

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  60
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M87K/M99L/L106R ECD

<400>  60

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Arg Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  61
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M99L/Y105L/I108F ECD

<400>  61

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  62
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/L98Q/Y105L ECD

<400>  62

Lys Ala Met His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  63
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56T/L91R/L98Q/Y105L ECD

<400>  63

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Arg Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  64
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/M87V/N110K/I117E ECD

<400>  64

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Glu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  65
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/L98Q/M99L/Y105L ECD

<400>  65

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  66
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/V46E/L63P/D65G/L98Q ECD

<400>  66

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Glu Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Gly Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  67
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/L98Q/Y105L ECD

<400>  67

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  68
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/E59G/L63P/L98Q/Y105L ECD

<400>  68

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  69
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/L63P/S72G/L98Q/Y105L ECD

<400>  69

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  70
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6T/A26T/M55T/M99L/Y105L ECD

<400>  70

Lys Ala Met His Val Thr Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  71
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/D65G/L98Q/M99L/Y105L ECD

<400>  71

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Gly Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  72
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/D64V/S72G/L98Q/M99L/Y105L ECD

<400>  72

Lys Ala Met His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Val 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  73
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/D43N/N58S/L63P/L98Q/M99L/Y105L ECD

<400>  73

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asn Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  74
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/A26T/L63P/D64E/L98Q/Y105L/L106R/N110K ECD

<400>  74

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Glu 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Arg Gly Ile Gly Lys Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  75
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A19V/G29W/R35K/L63P/L98Q/M99L/Y105L ECD

<400>  75

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Val Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Lys Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  76
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/S72G/T89M/L98Q/M99L/Y105L ECD

<400>  76

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Met Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  77
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98R/M99L/Y105L ECD

<400>  77

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  78
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E24Q/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  78

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Gln Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  79
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29R/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  79

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Arg Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  80
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L ECD

<400>  80

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  81
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q41L/Y54F/M56K/M99L/I108F ECD

<400>  81

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Leu Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  82
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/L98Q/M99L/Y105L/I117T ECD

<400>  82

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Thr Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  83
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56R/L63P/L98Q/M99L/Y105L ECD

<400>  83

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Arg Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  84
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L ECD

<400>  84

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  85
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L/L106I ECD

<400>  85

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  86
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55R/L98Q/M99L/Y105L ECD

<400>  86

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Arg Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  87
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/M87A/L98Q/Y105L ECD

<400>  87

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Ala Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  88
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26D/S72G/L98Q/M99L/Y105L ECD

<400>  88

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Asp Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  89
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22A/L63P/L98Q/M99L/Y105L/P119H ECD

<400>  89

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Ala Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp His Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  90
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/L98Q/M99L/Y105L ECD

<400>  90

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  91
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33V/A42S/M55T/L98Q/M99L/Y105L ECD

<400>  91

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ser Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  92
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/Q82R/L98Q/Y105L ECD

<400>  92

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  93
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L/I117L ECD

<400>  93

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  94
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/I67N/S72G/L98Q/M99L/Y105L ECD

<400>  94

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Asn Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  95
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/A26T/L63P/L98Q/Y105L/L106R ECD

<400>  95

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Arg Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  96
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S20N/A26T/L63P/L98Q/M99L/Y105L ECD

<400>  96

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Asn Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  97
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T61I/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  97

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Ile Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  98
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/T69I/L98Q/M99L/Y105L ECD

<400>  98

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ile Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  99
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L/L106N ECD

<400>  99

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Asn Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  100
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/T69A/L98Q/M99L/Y105L/L106R/V116A ECD

<400>  100

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Ala Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Arg Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Ala Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  101
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L ECD

<400>  101

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  102
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/D65G/S72G/L98Q/Y105L ECD

<400>  102

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Gly Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  103
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T53S/M56V/L98Q/Y105L ECD

<400>  103

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  104
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/Y105L ECD

<400>  104

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  105
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18A/L63P/S72G/L98Q/Y105L ECD

<400>  105

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ala Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  106
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/L98Q/Y105L ECD

<400>  106

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  107
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/G29W/L63P/S72G/L98Q/Y105L ECD

<400>  107

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  108
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/L106I ECD

<400>  108

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  109
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/I67V/S72G/L98Q/Y105L ECD

<400>  109

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Val Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  110
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M55V/E59G/L63P/L98Q/Y105L ECD

<400>  110

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Val Met Gly Asn Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  111
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/I117L ECD

<400>  111

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  112
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/Y105L/L106I/I117L ECD

<400>  112

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  113
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q/Y105L ECD

<400>  113

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  114
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/L63P/S72G/L98Q/Y105L ECD

<400>  114

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  115
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/L63P/S72G/L98Q/Y105L/L106I ECD

<400>  115

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  116
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/L106I/I117L ECD

<400>  116

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  117
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L/L106I ECD

<400>  117

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  118
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/L63P/L98Q/Y105L/L106I/I117L ECD

<400>  118

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  119
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/M87V/L98Q/Y105L ECD

<400>  119

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  120
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/S72G/Q76R/L98Q/Y105L/L106I/Q113H ECD

<400>  120

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Arg Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


His Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  121
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L/L106V ECD

<400>  121

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Val Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  122
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/L98Q/M99L/Y105L ECD

<400>  122

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  123
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58D/I67V/L98Q/M99L/Y105L ECD

<400>  123

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asp Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Val Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  124
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I67V/S72G/Q82H/T89A/L98Q/M99L/Y105L ECD

<400>  124

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Val Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  125
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/R85G/L98Q/M99L/Y105L/L106I ECD

<400>  125

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Gly Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  126
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T47A/M56K/L63P/S72G/Q82R/L98Q/M99L/Y105L ECD

<400>  126

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Ala Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  127
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  127

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  128
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/I18V/A42T/M55T/N58D/L98R/Y105L/L106I/P121S ECD

<400>  128

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Val Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Met Gly Asp Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Arg Met Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  129
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/S72G/L98Q/Y105L ECD

<400>  129

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  130
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/K30R/S72G/Q82R/L98Q/M99L/Y105L ECD

<400>  130

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Arg Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  131
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L/L106N/I117L ECD

<400>  131

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Asn Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  132
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/I93V/L98Q/M99L/Y105L ECD

<400>  132

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  133
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  133

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  134
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/Q82H/L98Q/M99I/Y105L ECD

<400>  134

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile His Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Ile Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  135
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18F/L63P/L98Q/M99L/Y105L/P121S ECD

<400>  135

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Phe Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  136
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L/I108V ECD

<400>  136

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  137
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/A42V/Q45H/I67N/M87K/E97Q/M99L ECD

<400>  137

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Val Asp Ser His Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Asn Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Gln Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  138
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V/E59G/L63P/S72G/M87K/I93V/L98Q/M99L/Y105L/I117E ECD

<400>  138

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Glu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  139
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/T89S/L98Q/M99L/Y105L/I108V/I117L ECD

<400>  139

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Lys Asp Ser Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  140
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/M56V/L63P/V96I/L98Q/M99L/Y105L/Y115H ECD

<400>  140

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile His Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  141
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/T61N/L63P/L98Q/Y105L ECD

<400>  141

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Asn Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  142
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26S/M55T/M56V/L63P/S72G/L98Q/M99L/Y105L/I117K ECD

<400>  142

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ser Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Lys Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  143
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/T61R/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  143

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  144
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L ECD

<400>  144

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  145
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L/I108F ECD

<400>  145

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Phe Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  146
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/R16H/A26T/T61S/L63P/M87V/L98Q/M99L/Y105L/L106I/I117L ECD

<400>  146

Lys Ala Met His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Ser Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Leu Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  147
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L/P121S ECD

<400>  147

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  148
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/P121S ECD

<400>  148

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  149
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  149

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  150
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L/I108V ECD

<400>  150

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Val Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  151
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/L63P/S72G/L98Q/Y105L ECD

<400>  151

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  152
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/G29W/T53S/M56K/L63P/L98Q/Y105L/P121S ECD

<400>  152

Lys Ala Met His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  153
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  CTLA-4 ECD

<400>  153

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln 
        115                 120                 125         


<210>  154
<211>  126
<212>  PRT
<213>  artificial sequence

<220>
<223>  Belatacept ECD with C121C

<400>  154

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  155
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  CTLA-4 ECD

<400>  155

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln 
        115                 120                 125         


<210>  156
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 ECD

<400>  156

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp 
        115                 120                 125     


<210>  157
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T89A/L98Q/M99L/Y105L/L106I/Y115N/E120D/C122P/D124P/S125I/D126P 
       ECD

<400>  157

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Ile Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Asn Val Ile Asp Pro Asp Pro Pro Pro Pro Ile Pro 
        115                 120                 125     


<210>  158
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N58S/L63P/T71A/S72G/L98Q/M99L/Y105L/D124I/S125P/D126T ECD

<400>  158

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Ala Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Ile Pro Thr 
        115                 120                 125     


<210>  159
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16G/E33M/N58S/E59G/L63P/L98Q/Y105L/E120D/C122P/D124P/S125I/D126P
       ECD

<400>  159

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Gly 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Gly Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Asp Pro Pro Pro Pro Ile Pro 
        115                 120                 125     


<210>  160
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/P121S/D126T ECD

<400>  160

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Ser Cys Pro Asp Ser Thr 
        115                 120                 125     


<210>  161
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12H/E33M/L98Q/Y105L ECD

<400>  161

Lys Ala Met His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Met Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  162
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  162

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  163
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M55T/M56K/L63P/L98Q/M99L/Y105L ECD

<400>  163

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Thr Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  164
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M56K/L63P/L98Q/Y105L ECD

<400>  164

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  165
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/L98Q ECD

<400>  165

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  166
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/Y105L ECD

<400>  166

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  167
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q ECD

<400>  167

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  168
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/Y105L ECD

<400>  168

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  169
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/L98Q/Y105L ECD

<400>  169

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  170
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/M87V/L98Q/Y105L ECD

<400>  170

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  171
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/L63P/M87V/L98Q/Y105L ECD

<400>  171

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  172
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  172

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  173
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56K/N58S/L63P/M87V/L98Q/Y105L ECD

<400>  173

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  174
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/Y105L ECD

<400>  174

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  175
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L/Y105L ECD

<400>  175

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  176
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/M99L  ECD

<400>  176

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  177
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L ECD

<400>  177

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Val Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Leu Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  178
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q ECD

<400>  178

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  179
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/Y105L ECD

<400>  179

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  180
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/L98Q/Y105L ECD

<400>  180

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  181
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/M56T/L98Q/Y105L ECD

<400>  181

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  182
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/L98Q/Y105L ECD

<400>  182

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  183
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/G29W/L98Q/Y105L ECD

<400>  183

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  184
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/L98Q/Y105L ECD

<400>  184

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  185
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16H/L98Q/Y105L ECD

<400>  185

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  186
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L98Q/Y105L ECD

<400>  186

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  187
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56T/L98Q/Y105L ECD

<400>  187

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  188
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/S72G/L98Q/Y105L ECD

<400>  188

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  189
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/S72G/L98Q/Y105L ECD

<400>  189

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  190
<211>  126
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T, T61R, L63P, S72G, L98Q, M99L, P102L, Y105L ECD

<400>  190

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Thr Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Leu Tyr Pro Leu Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  191
<211>  102
<212>  PRT
<213>  artificial sequence

<220>
<223>  unmodified CTLA-4 IgV (39-140 of P16410.3)

<400>  191

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  192
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/Y105L IgV

<400>  192

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  193
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98R IgV domain (of L63P/L98R/N110K - IgV doesn't contain 
       N110 residue)

<400>  193

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  194
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T IgV domain

<400>  194

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  195
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P IgV domain

<400>  195

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  196
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/Y105L IgV domain

<400>  196

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  197
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/Y105L IgV domain

<400>  197

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  198
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P IgV domain

<400>  198

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  199
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98R IgV domain (of L98R/N110K - IgV doesn't contain N110 
       residue)

<400>  199

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  200
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/L98Q/M99L/Y105L IgV domain

<400>  200

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  201
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/Q82H/L98Q/M99L/Y105L IgV domain

<400>  201

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  202
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  202

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  203
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S14N/R16C/I18T/M56K/T61A/L63P/A86T/M99L IgV domain

<400>  203

His Val Ala Gln Pro Ala Val Val Leu Ala Asn Ser Cys Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Ala Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Thr Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  204
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S27P/M56K/L63P/S72G/S73R/T89A/M99L/Y105L IgV domain

<400>  204

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Pro Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Arg Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  205
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56K/L63P/N75D/V96I/M99L/Y105L IgV domain

<400>  205

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asp Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  206
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/Y105L IgV domain

<400>  206

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  207
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q/M99L/Y105L IgV domain

<400>  207

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  208
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/Y105L IgV domain

<400>  208

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  209
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/L98Q IgV domain

<400>  209

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  210
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L98Q/M99L/Y105L IgV domain

<400>  210

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  211
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T37S/M56V/L98Q/Y105L IgV domain

<400>  211

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Ser Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  212
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/Y54F/M56K/M99L/Y105L IgV domain

<400>  212

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  213
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/I18T/A26T/M55T/T69S/S72G/M99L/Y105L IgV domain

<400>  213

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ser Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  214
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22I/L63P/L98Q/Y105L IgV domain

<400>  214

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Ile Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  215
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  215

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  216
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/A42T/L98Q/Y105L IgV domain

<400>  216

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  217
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/E97Q/M99L/Y105F IgV domain

<400>  217

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Gln Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Phe 
            100         


<210>  218
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/S72G/L98Q/M99L/Y105L IgV domain

<400>  218

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  219
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  R16C/G29W/E33V/M55T/L63P/L98Q/Y105L IgV domain

<400>  219

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Cys Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  220
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56L/L63P/L98Q/Y105L IgV domain

<400>  220

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Leu Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  221
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S15P/I18V/M56T/L98Q/M99L/Y105L IgV domain

<400>  221

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Pro Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  222
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29W/L63P/L98Q/Y105L IgV domain

<400>  222

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  223
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/Q82H/L98Q/M99L/Y105L IgV domain

<400>  223

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  224
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L98Q/M99L/Y105L IgV domain

<400>  224

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  225
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M55T/L63P/T71I/M99L/Y105L IgV domain

<400>  225

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Ile Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  226
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/M56K/L63P/L98Q/Y105L IgV domain

<400>  226

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  227
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/Q82R/L98Q/Y105L IgV domain

<400>  227

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  228
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/M55T/E59D/L63P/M99L IgV domain

<400>  228

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Asp Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  229
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/Y105L IgV domain

<400>  229

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  230
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  230

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  231
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T61A/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  231

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Ala Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  232
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V38I/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  232

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Ile Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  233
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/I93L/L98Q/M99L/Y105L IgV domain

<400>  233

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Leu Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  234
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12I/M55T/M56V/I67T/M99L IgV domain

<400>  234

His Val Ala Gln Pro Ala Val Val Ile Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Thr 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  235
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/A26T/L63H/T89A/L98Q/M99L/Y105L IgV domain

<400>  235

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Asn Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe His Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  236
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/E48R/L63P/T69S/L98Q/Y105L IgV domain

<400>  236

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Arg Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ser Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  237
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18N/L63P/S72T/M87T/L98Q/Y105L IgV domain

<400>  237

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Asn Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Thr Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  238
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M56T/L63P/L98Q/Y105L IgV domain

<400>  238

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  239
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/M87T/L98Q/M99L/Y105L IgV domain

<400>  239

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Thr Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  240
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/D64N/L98Q/M99L/Y105L IgV domain

<400>  240

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asn Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  241
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/L63P/S72G/M87K/L98Q/M99L/Y105L IgV domain

<400>  241

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  242
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V IgV domain

<400>  242

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  243
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/K95R IgV domain

<400>  243

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Arg Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  244
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M87K/M99L IgV domain

<400>  244

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  245
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/M99L/Y105L IgV domain

<400>  245

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  246
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/L98Q/Y105L IgV domain

<400>  246

His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  247
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56T/L91R/L98Q/Y105L IgV domain

<400>  247

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Arg Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  248
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/M87V IgV domain

<400>  248

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  249
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/L98Q/M99L/Y105L IgV domain

<400>  249

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  250
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/V46E/L63P/D65G/L98Q IgV domain

<400>  250

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Glu Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Gly Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  251
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/L98Q/Y105L IgV domain

<400>  251

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  252
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/E59G/L63P/L98Q/Y105L IgV domain

<400>  252

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  253
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/L63P/S72G/L98Q/Y105L IgV domain

<400>  253

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  254
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A6T/A26T/M55T/M99L/Y105L IgV domain

<400>  254

His Val Thr Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  255
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/D65G/L98Q/M99L/Y105L IgV domain

<400>  255

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Gly Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  256
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/L63P/D64V/S72G/L98Q/M99L/Y105L IgV domain

<400>  256

His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Val Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  257
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/D43N/N58S/L63P/L98Q/M99L/Y105L IgV domain

<400>  257

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asn Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  258
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/A26T/L63P/D64E/L98Q/Y105L IgV domain

<400>  258

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Glu Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  259
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A19V/G29W/R35K/L63P/L98Q/M99L/Y105L IgV domain

<400>  259

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Val 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Lys 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  260
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/A26T/L63P/S72G/T89M/L98Q/M99L/Y105L IgV domain

<400>  260

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Met Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  261
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98R/M99L/Y105L IgV domain

<400>  261

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  262
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E24Q/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  262

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Gln Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  263
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/G29R/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  263

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Arg Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  264
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Q41L/Y54F/M56K/M99L IgV domain

<400>  264

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Leu Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Phe Met Lys Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  265
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/L98Q/M99L/Y105L IgV domain

<400>  265

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  266
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56R/L63P/L98Q/M99L/Y105L IgV domain

<400>  266

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Arg Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  267
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33M/L63P/S72G/L98Q/Y105L IgV domain

<400>  267

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  268
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55R/L98Q/M99L/Y105L IgV domain

<400>  268

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Arg Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  269
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/M87A/L98Q/Y105L IgV domain

<400>  269

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Ala Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  270
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26D/S72G/L98Q/M99L/Y105L IgV domain

<400>  270

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Asp Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  271
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V22A/L63P/L98Q/M99L/Y105L IgV domain

<400>  271

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Ala Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  272
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/L98Q/M99L/Y105L IgV domain

<400>  272

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  273
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E33V/A42S/M55T/L98Q/M99L/Y105L IgV domain

<400>  273

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ser Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  274
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/Q82R/L98Q/Y105L IgV domain

<400>  274

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  275
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/I67N/S72G/L98Q/M99L/Y105L IgV domain

<400>  275

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Asn 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  276
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/A26T/L63P/L98Q/Y105L IgV domain

<400>  276

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  277
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S20N/A26T/L63P/L98Q/M99L/Y105L IgV domain

<400>  277

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Asn Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  278
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/T89S/L98Q/M99L/Y105L IgV domain

<400>  278

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Ser Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  279
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T61I/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  279

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Ile Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  280
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/T69I/L98Q/M99L/Y105L IgV domain

<400>  280

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ile Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  281
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  281

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  282
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/T69A/L98Q/M99L/Y105L IgV domain

<400>  282

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Ala Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  283
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/L98Q/Y105L IgV domain

<400>  283

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  284
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T53S/M56V/L98Q/Y105L IgV domain

<400>  284

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Val Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  285
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L63P/S72G/L98Q/Y105L IgV domain

<400>  285

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  286
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18A/L63P/S72G/L98Q/Y105L IgV domain

<400>  286

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ala Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  287
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/L98Q/Y105L IgV domain

<400>  287

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  288
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18V/G29W/L63P/S72G/L98Q/Y105L IgV domain

<400>  288

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  289
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L IgV domain

<400>  289

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  290
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/L63P/I67V/S72G/L98Q/Y105L IgV domain

<400>  290

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Val 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  291
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M55V/E59G/L63P/L98Q/Y105L IgV domain

<400>  291

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Val Met Gly Asn Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  292
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q/Y105L IgV domain

<400>  292

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  293
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/G29W/L63P/S72G/L98Q/Y105L IgV domain

<400>  293

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  294
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T53S/L63P/L98Q/Y105L IgV domain

<400>  294

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  295
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58S/L63P/S72G/M87V/L98Q/Y105L IgV domain

<400>  295

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  296
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/S72G/Q76R/L98Q/Y105L IgV domain

<400>  296

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Arg Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  297
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/L63P/L98Q/M99L/Y105L IgV domain

<400>  297

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  298
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/N58D/I67V/L98Q/M99L/Y105L IgV domain

<400>  298

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asp Glu Leu Thr Phe Leu Asp Asp Ser Val 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  299
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I67V/S72G/Q82H/T89A/L98Q/M99L/Y105L IgV domain

<400>  299

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Val 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  300
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S72G/R85G/L98Q/M99L/Y105L IgV domain

<400>  300

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Gly Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  301
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/T47A/M56K/L63P/S72G/Q82R/L98Q/M99L/Y105L IgV domain

<400>  301

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Ala Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  302
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/M55T/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  302

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  303
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12H/I18V/A42T/M55T/N58D/L98R/Y105L IgV domain

<400>  303

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Val Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Thr Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Met Gly Asp Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Arg Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  304
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26T/L63P/S72G/L98Q/Y105L IgV domain

<400>  304

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  305
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12F/K30R/S72G/Q82R/L98Q/M99L/Y105L IgV domain

<400>  305

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Arg Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  306
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/M87K/I93V/L98Q/M99L/Y105L IgV domain

<400>  306

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  307
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P28L/E33V/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  307

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Leu Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  308
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/L63P/Q82H/L98Q/M99I/Y105L IgV domain

<400>  308

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile His Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Ile 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  309
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18F/L63P/L98Q/M99L/Y105L IgV domain

<400>  309

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Phe Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  310
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A26T/A42V/Q45H/I67N/M87K/E97Q/M99L IgV domain

<400>  310

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Val Asp Ser His Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Asn 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Ile Cys Lys Val Gln Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  311
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M56V/E59G/L63P/S72G/M87K/I93V/L98Q/M99L/Y105L IgV domain

<400>  311

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Lys Asp Thr Gly Leu Tyr Val Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  312
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/M56V/L63P/V96I/L98Q/M99L/Y105L IgV domain

<400>  312

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Val Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Ile Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  313
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/T61N/L63P/L98Q/Y105L IgV domain

<400>  313

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Asn Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  314
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/A26S/M55T/M56V/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  314

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ser Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Val Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  315
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  I18T/T61R/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  315

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  316
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/L63P/S72G/L98Q/M99L/Y105L IgV domain

<400>  316

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  317
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  L12P/R16H/A26T/T61S/L63P/M87V/L98Q/M99L/Y105L IgV domain

<400>  317

His Val Ala Gln Pro Ala Val Val Pro Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Ser Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  318
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/M56K/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  318

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  319
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G29W/T53S/L63P/S72G/L98Q/Y105L IgV domain

<400>  319

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  320
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V10A/G29W/T53S/M56K/L63P/L98Q/Y105L IgV domain

<400>  320

His Val Ala Gln Pro Ala Ala Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  321
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CTLA-4 IgV

<400>  321

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  322
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T89A/L98Q/M99L/Y105L/L106I/Y115N/E120D/C122P/D124P/S125I/D126P 
       IgV domain

<400>  322

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Ala Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  323
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N58S/L63P/T71A/S72G/L98Q/M99L/Y105L/D124I/S125P/D126T IgV domain

<400>  323

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Ala Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  324
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16G/E33M/N58S/E59G/L63P/L98Q/Y105L/E120D/C122P/D124P/S125I/D126P
       IgV

<400>  324

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Gly Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Ser Gly Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  325
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L63P/S72G/L98Q/Y105L/P121S/D126T IgV domain

<400>  325

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  326
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12H/E33M/L98Q/Y105L IgV domain

<400>  326

His Val Ala Gln Pro Ala Val Val His Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Met Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  327
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  327

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  328
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M55T/M56K/L63P/L98Q/ M99L/Y105L IgV domain

<400>  328

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Thr Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  329
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  I18T/A26T/M56K/L63P/L98Q/Y105L IgV domain

<400>  329

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Thr Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  330
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/L98Q IgV domain

<400>  330

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  331
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/L63P/Y105L IgV domain

<400>  331

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  332
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/L98Q IgV domain

<400>  332

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  333
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/M87V/Y105L IgV domain

<400>  333

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  334
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/L63P/L98Q/Y105L IgV domain

<400>  334

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  335
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/N58S/M87V/L98Q/Y105L IgV domain

<400>  335

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Ser Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  336
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/M56K/L63P/M87V/L98Q/Y105L IgV domain

<400>  336

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Lys Gly Asn Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  337
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  T53S/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  337

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Ser Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  338
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56K/N58S/L63P/M87V/L98Q/Y105L IgV domain

<400>  338

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Lys Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Val Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  339
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/Y105L IgV domain

<400>  339

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  340
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L/Y105L IgV domain

<400>  340

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  341
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/L98Q/M99L  IgV domain

<400>  341

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  342
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  E33V/M99L IgV domain

<400>  342

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Val Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Leu 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  343
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/L98Q IgV domain

<400>  343

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Tyr 
            100         


<210>  344
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/M56T/Y105L IgV domain

<400>  344

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  345
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/G29W/L98Q/Y105L IgV domain

<400>  345

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  346
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/R16H/M56T/L98Q/Y105L IgV domain

<400>  346

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  347
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/L98Q/Y105L IgV domain

<400>  347

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  348
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/G29W/L98Q/Y105L IgV domain

<400>  348

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  349
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  L12F/L98Q/Y105L IgV domain

<400>  349

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  350
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  R16H/L98Q/Y105L IgV domain

<400>  350

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  351
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/L98Q/Y105L IgV domain

<400>  351

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  352
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  M56T/L98Q/Y105L IgV domain

<400>  352

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  353
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>   L12F/R16H/G29W/M56T/S72G/L98Q/Y105L IgV domain

<400>  353

His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  354
<211>  102
<212>  PRT
<213>  Artificial sequence

<220>
<223>  G29W/M56T/S72G/L98Q/Y105L IgV domain

<400>  354

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
                85                  90                  95      


Tyr Pro Pro Pro Tyr Leu 
            100         


<210>  355
<211>  102
<212>  PRT
<213>  artificial sequence

<220>
<223>  I18T, T61R, L63P, S72G, L98Q, M99L, P102L, Y105L IgV domain

<400>  355

His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Thr Ala 
1               5                   10                  15      


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
            20                  25                  30          


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
        35                  40                  45              


Ala Thr Tyr Met Met Gly Asn Glu Leu Arg Phe Pro Asp Asp Ser Ile 
    50                  55                  60                  


Cys Thr Gly Thr Gly Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
65                  70                  75                  80  


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Leu 
                85                  90                  95      


Tyr Pro Leu Pro Tyr Leu 
            100         


<210>  356
<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA WT ECD

<400>  356

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  357
<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA H19Y ECD

<400>  357

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  358
<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA H19Y, S30G ECD

<400>  358

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Gly Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  359
<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA H19Y, V45A ECD

<400>  359

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Ala Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  360
<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA F14Y, H19Y ECD

<400>  360

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Tyr Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  361
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, V45D ECD

<400>  361

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Asp Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  362
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, A43E ECD

<400>  362

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Glu Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  363
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T36A ECD

<400>  363

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Ala Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  364
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, I22V ECD

<400>  364

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Val Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  365
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11D, H19Y ECD

<400>  365

Leu Gln Met Ala Gly Gln Cys Ser Gln Asp Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  366
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T36M ECD

<400>  366

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Met Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  367
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11S, H19Y ECD

<400>  367

Leu Gln Met Ala Gly Gln Cys Ser Gln Ser Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  368
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, L35P, T46A ECD

<400>  368

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Pro Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Ala Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  369
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, N47D ECD

<400>  369

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asp Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  370
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9D, H19Y ECD

<400>  370

Leu Gln Met Ala Gly Gln Cys Asp Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  371
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, S30G, V45D ECD

<400>  371

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Gly Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Asp Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  372
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R39Q ECD

<400>  372

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  373
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, L35P ECD

<400>  373

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Pro Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  374
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9D, H19Y, R27H ECD

<400>  374

Leu Gln Met Ala Gly Gln Cys Asp Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu His Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  375
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA Q10P, H19Y, Q25H ECD

<400>  375

Leu Gln Met Ala Gly Gln Cys Ser Pro Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys His Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  376
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R39L, N47D ECD

<400>  376

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Leu Tyr Cys Asn Ala Ser Val Thr Asp Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  377
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11D, H19Y, N47D ECD

<400>  377

Leu Gln Met Ala Gly Gln Cys Ser Gln Asp Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asp Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  378
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32S ECD

<400>  378

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Ser Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  379
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11S, H19Y, S29P ECD

<400>  379

Leu Gln Met Ala Gly Gln Cys Ser Gln Ser Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Pro Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  380
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R39Q, N47D ECD

<400>  380

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asp Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  381
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S16A, H19Y, R39Q ECD

<400>  381

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ala Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  382
<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA S9N, H19Y, N31K, T46I ECD

<400>  382

Leu Gln Met Ala Gly Gln Cys Asn Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Lys Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Ile Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  383
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R27L, N31Y, T32S, T36A ECD

<400>  383

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Leu Cys Ser Ser Tyr Ser Pro 
            20                  25                  30          


Pro Leu Ala Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  384
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11S, H19Y, T46A ECD

<400>  384

Leu Gln Met Ala Gly Gln Cys Ser Gln Ser Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Ala Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  385
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32I ECD

<400>  385

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Ile Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  386
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9G, H19Y, T36S, A43S ECD

<400>  386

Leu Gln Met Ala Gly Gln Cys Gly Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Ser Cys Gln Arg Tyr Cys Asn Ser Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  387
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, S48G ECD

<400>  387

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Gly Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  388
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9N, H19Y, I22V, N31D ECD

<400>  388

Leu Gln Met Ala Gly Gln Cys Asn Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Val Pro Cys Gln Leu Arg Cys Ser Ser Asp Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  389
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9N, H19Y, Q25K, N31D ECD

<400>  389

Leu Gln Met Ala Gly Gln Cys Asn Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Lys Leu Arg Cys Ser Ser Asp Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  390
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9G, H19Y, T32S ECD

<400>  390

Leu Gln Met Ala Gly Gln Cys Gly Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Ser Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  391
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T36A, N47Y ECD

<400>  391

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Ala Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Tyr Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  392
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, V45A, T46I ECD

<400>  392

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Ala Ile Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  393
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, Q25K, N31D ECD

<400>  393

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Lys Leu Arg Cys Ser Ser Asp Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  394
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, Q25H, R39Q, V45D ECD

<400>  394

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys His Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Asp Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  395
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32S, N47D ECD

<400>  395

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Ser Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asp Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  396
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA Q10E, H19Y, A20T, T36S ECD

<400>  396

Leu Gln Met Ala Gly Gln Cys Ser Glu Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Thr Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  397
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32S, V45I ECD

<400>  397

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Ser Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Ile Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  398
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19A ECD

<400>  398

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Ala Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  399
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19C ECD

<400>  399

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Cys Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  400
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19D ECD

<400>  400

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Asp Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  401
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19E ECD

<400>  401

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Glu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  402
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F ECD

<400>  402

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  403
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19G ECD

<400>  403

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Gly Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  404
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19I ECD

<400>  404

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Ile Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  405
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19K ECD

<400>  405

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Lys Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  406
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L ECD

<400>  406

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  407
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19M ECD

<400>  407

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Met Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  408
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19N ECD

<400>  408

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Asn Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  409
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19P ECD

<400>  409

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Pro Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  410
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Q ECD

<400>  410

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Gln Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  411
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19R ECD

<400>  411

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Arg Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  412
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19S ECD

<400>  412

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Ser Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  413
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19T ECD

<400>  413

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Thr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  414
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19V ECD

<400>  414

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Val Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  415
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19W ECD

<400>  415

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Trp Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  416
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25E, N31L, L35Y, T36S ECD

<400>  416

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Glu Leu Arg Cys Ser Ser Leu Thr Pro 
            20                  25                  30          


Pro Tyr Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  417
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31S, T36S ECD

<400>  417

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Phe Leu Arg Cys Ser Ser Ser Thr Pro 
            20                  25                  30          


Pro Leu Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  418
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19I, Q25F, N31S, T36V ECD

<400>  418

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Ile Ala Cys Ile Pro Cys Phe Leu Arg Cys Ser Ser Ser Thr Pro 
            20                  25                  30          


Pro Leu Val Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  419
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25V, N31M, T36S ECD

<400>  419

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Val Leu Arg Cys Ser Ser Met Thr Pro 
            20                  25                  30          


Pro Leu Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  420
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, Q25Y, N31L, L35Y, T36S ECD

<400>  420

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Tyr Leu Arg Cys Ser Ser Leu Thr Pro 
            20                  25                  30          


Pro Tyr Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  421
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25I, N31M, L35A, T36S ECD

<400>  421

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Ile Leu Arg Cys Ser Ser Met Thr Pro 
            20                  25                  30          


Pro Ala Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  422
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19I, Q25L, N31L, L35Y, T36S ECD

<400>  422

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Ile Ala Cys Ile Pro Cys Leu Leu Arg Cys Ser Ser Leu Thr Pro 
            20                  25                  30          


Pro Tyr Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  423
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25L, N31G, L35P, T36A ECD

<400>  423

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Leu Leu Arg Cys Ser Ser Gly Thr Pro 
            20                  25                  30          


Pro Pro Ala Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  424
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, I22L, N31G ECD

<400>  424

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Leu Pro Cys Gln Leu Arg Cys Ser Ser Gly Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  425
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, I22V, Q25M, N31P, T36M ECD

<400>  425

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Val Pro Cys Met Leu Arg Cys Ser Ser Pro Thr Pro 
            20                  25                  30          


Pro Leu Met Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  426
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, N31L, L35Y, T36S ECD

<400>  426

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Leu Thr Pro 
            20                  25                  30          


Pro Tyr Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  427
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, S30G, N31H, L35A ECD

<400>  427

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Gly His Thr Pro 
            20                  25                  30          


Pro Ala Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  428
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, Q25S, N31V, L35S, T36V ECD

<400>  428

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Ser Leu Arg Cys Ser Ser Val Thr Pro 
            20                  25                  30          


Pro Ser Val Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  429
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, Q25S, S30Y, N31G, L35M, T36V ECD

<400>  429

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Ser Leu Arg Cys Ser Tyr Gly Thr Pro 
            20                  25                  30          


Pro Met Val Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  430
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31L, L35Y, T36S ECD

<400>  430

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Phe Leu Arg Cys Ser Ser Leu Thr Pro 
            20                  25                  30          


Pro Tyr Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  431
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31S, T36G ECD

<400>  431

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Phe Leu Arg Cys Ser Ser Ser Thr Pro 
            20                  25                  30          


Pro Leu Gly Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  432
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, I22V, Q25S, N31V, L35S, T36V ECD

<400>  432

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Val Pro Cys Ser Leu Arg Cys Ser Ser Val Thr Pro 
            20                  25                  30          


Pro Ser Val Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  433
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25G, N31S, L35V, T36N ECD

<400>  433

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Gly Leu Arg Cys Ser Ser Ser Thr Pro 
            20                  25                  30          


Pro Val Asn Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  434
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, Q25H, N31D, L35S ECD

<400>  434

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys His Leu Arg Cys Ser Ser Asp Thr Pro 
            20                  25                  30          


Pro Ser Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  435
<211>  53
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31S, L35Y, T36S ECD

<400>  435

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Phe Ala Cys Ile Pro Cys Phe Leu Arg Cys Ser Ser Ser Thr Pro 
            20                  25                  30          


Pro Tyr Ser Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala 
    50              


<210>  436
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA WT ECD

<400>  436
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gcacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  437
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y ECD

<400>  437
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  438
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, S30G ECD

<400>  438
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actcattgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaggcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  439
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, V45A ECD

<400>  439
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc agctgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ctaccaacag tgtcaaaggg actaatgcg                             159


<210>  440
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA F14Y, H19Y ECD

<400>  440
ctgcaaatgg ccgggcagtg tagccagaac gaatactatg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  441
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, V45D ECD

<400>  441
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatccg ataccaacag tgtcaaaggg actaatgcg                             159


<210>  442
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, A43E ECD

<400>  442
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgaatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  443
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T36A ECD

<400>  443
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcgcgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  444
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, I22V ECD

<400>  444
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

gttccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  445
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11D, H19Y ECD

<400>  445
ctgcaaatgg ccgggcagtg cagccaggac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  446
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T36M ECD

<400>  446
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccatgcc aactgcgctg ttcaagcaac acccccccgc tcatgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  447
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11S, H19Y ECD

<400>  447
ctgcaaatgg ccgggcagtg cagccagagc gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  448
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, L35P, T46A ECD

<400>  448
ctgcaaatgg ccgggcagtg cagtcagaac gaatactttg actccttgtt gtacgcatgt       60

attccatgcc aactacgctg ttcaagcaac acccccccgc ccacgtgtca gcggtactgc      120

aacgcatctg ttgccaacag tgtcaaaggg actaatgcg                             159


<210>  449
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, N47D ECD

<400>  449
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccgacag tgtcaaaggg actaatgcg                             159


<210>  450
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9D, H19Y ECD

<400>  450
ctgcaaatgg ccgggcagtg cgaccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  451
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, S30G, V45D ECD

<400>  451
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcgtgt       60

attccttgcc aactgcgctg ttcaggcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ataccaacag tgtcaaaggg actaatgcg                             159


<210>  452
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R39Q ECD

<400>  452
ctgcaaatgg ccgggcagtg cagtcagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcagtactgc      120

aacgcatctg ttaccaatag tgtcaaaggg actaatgcg                             159


<210>  453
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, L35P ECD

<400>  453
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccatgcc aactacgctg ttcaagcaac acccccccgc ccacgtgtca gcggtactgc      120

aacgcatctg ttaccaatag tgtcaaaggg actaatgcg                             159


<210>  454
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9D, H19Y, R27H ECD

<400>  454
ctgcaaatgg ccgggcagtg cgaccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcactg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  455
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA Q10P, H19Y, Q25H ECD

<400>  455
ctgcaaatgg ccgggcagtg cagccctaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc atctgcgctg ttcaagcaac acacccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  456
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R39L, N47D ECD

<400>  456
ctgcaaatgg ccgggcagtg cagtcagaac gaatactttg actccttgtt gtacgcatgt       60

ataccttgcc aactgcgctg ttctagtaac acaccaccgc tcacgtgtca gctgtactgc      120

aacgcatctg ttaccgacag tgtcaaaggg actaatgcg                             159


<210>  457
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11D, H19Y, N47D ECD

<400>  457
ctgcaaatgg ccgggcagtg cagccaggac gaatactttg actcattgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccgacag tgtcaaaggg actaatgcg                             159


<210>  458
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32S ECD

<400>  458
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac tcacccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  459
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11S, H19Y, S29P ECD

<400>  459
ctgcaaatgg ccgggcagtg cagccagagc gaatactttg actccttgtt gtacgcatgt       60

attccgtgcc aactgcgctg tccaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  460
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R39Q, N47D ECD

<400>  460
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccctgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcagtactgc      120

aacgcatctg ttaccgacag tgtcaaaggg actaatgcg                             159


<210>  461
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S16A, H19Y, R39Q ECD

<400>  461
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg acgccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcagtactgc      120

aacgcatctg ttaccaatag tgtcaaaggg actaatgcg                             159


<210>  462
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9N, H19Y, N31K, T46I ECD

<400>  462
ctgcaaatgg ccgggcagtg caaccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaag actcccccgc tcacgtgtca gcggtactgc      120

aacgcatcag ttatcaacag tgtcaaaggg actaatgcg                             159


<210>  463
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, R27L, N31Y, T32S, T36A ECD

<400>  463
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgctatg ttcaagctac agccccccgc tcgcgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  464
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA N11S, H19Y, T46A ECD

<400>  464
ctgcaaatgg ccgggcagtg cagccagagc gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgatg ttcgagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttgctaacag tgtcaaaggg actaatgcg                             159


<210>  465
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32I ECD

<400>  465
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac atccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  466
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9G, H19Y, T36S, A43S ECD

<400>  466
ctgcaaatgg ccgggcagtg cggccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tctcgtgtca gcggtactgc      120

aactcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  467
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, S48G ECD

<400>  467
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacgg tgtcaaaggg actaatgcg                             159


<210>  468
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9N, H19Y, I22V, N31D ECD

<400>  468
ctgcaaatgg ccgggcagtg caaccagaac gaatactttg actccttgtt gtacgcatgt       60

gttccttgcc aactgcgctg ttcaagcgac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  469
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9N, H19Y, Q25K, N31D ECD

<400>  469
ctgcaaatgg ccgggcagtg caaccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgca aactgcgctg ttcaagcgac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  470
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA S9G, H19Y, T32S ECD

<400>  470
ctgcaaatgg ccgggcagtg cggccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac tcccctccgc tcacgtgtca gcggtactgc      120

aatgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  471
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T36A, N47Y ECD

<400>  471
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc agctgcgctg ttcaagcaac acccccccgc tcgcgtgtca gcggtactgc      120

aatgcatctg ttacctacag tgtcaaaggg actaatgcg                             159


<210>  472
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, V45A, T46I ECD

<400>  472
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt atacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ctatcaacag tgtcaaaggg actaatgcg                             159


<210>  473
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, Q25K, N31D ECD

<400>  473
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgca aactgcgctg ttcaagcgac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  474
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, Q25H, R39Q, V45D ECD

<400>  474
ctgcaaatgg ccgggcagtg tagccagaac gaatactttg actccttgtt gtacgcgtgt       60

attccctgcc atctgcgctg ttcgagcaac acccccccac tcacatgtca gcagtactgc      120

aacgcatctg ataccaacag tgtcaaaggg actaatgcg                             159


<210>  475
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32S, N47D ECD

<400>  475
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac tcacccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccgacag tgtcaaaggg actaatgcg                             159


<210>  476
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA Q10E, H19Y, A20T, T36S ECD

<400>  476
ctgcaaatgg ccgggcagtg cagcgagaac gaatactttg actccttgtt gtacacatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tctcgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  477
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, T32S, V45I ECD

<400>  477
ctgcaaatgg ccgggcagtg tagccagaac gaatactttg actccttgtt gtacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac tcccccccgc tcacgtgtca gcggtactgc      120

aacgcatcca ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  478
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19A ECD

<400>  478
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt ggcagcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  479
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19C ECD

<400>  479
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtgtgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  480
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19D ECD

<400>  480
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt ggacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  481
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19E ECD

<400>  481
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt ggaggcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  482
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F ECD

<400>  482
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gttcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  483
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19G ECD

<400>  483
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gggcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  484
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19I ECD

<400>  484
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gatcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  485
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19K ECD

<400>  485
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gaaggcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  486
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA  H19L ECD

<400>  486
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gctcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  487
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19M ECD

<400>  487
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gatggcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  488
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19N ECD

<400>  488
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gaatgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  489
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19P ECD

<400>  489
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gcctgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  490
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Q ECD

<400>  490
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gcaggcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  491
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19R ECD

<400>  491
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gcgagcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  492
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19S ECD

<400>  492
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtccgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  493
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19T ECD

<400>  493
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gacagcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  494
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19V ECD

<400>  494
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt ggtagcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  495
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19W ECD

<400>  495
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtgggcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  496
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25E, N31L, L35Y, T36S ECD

<400>  496
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgcg agctgcgctg ttcaagcttg acccccccgt atagttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  497
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31S, T36S ECD

<400>  497
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgct ttctgcgctg ttcaagctct acccccccgc tgtcttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  498
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19I, Q25F, N31S, T36V ECD

<400>  498
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gattgcatgt       60

attccttgct ttctgcgctg ttcaagctcg acccccccgc ttgtttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  499
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25V, N31M, T36S ECD

<400>  499
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgcg tgctgcgctg ttcaagcatg acccccccgc tgtcttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  500
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, Q25Y, N31L, L35Y, T36S ECD

<400>  500
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtatgcatgt       60

attccttgct atctgcgctg ttcaagcttg acccccccgt atagttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  501
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25I, N31M, L35A, T36S ECD

<400>  501
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgca ttctgcgctg ttcaagcatg acccccccgg cgtcgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  502
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19I, Q25L, N31L, L35Y, T36S ECD

<400>  502
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gattgcatgt       60

attccttgct tgctgcgctg ttcaagcttg acccccccgt atagttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  503
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25L, N31G, L35P, T36A ECD

<400>  503
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgct tgctgcgctg ttcaagcggt acccccccgc cggcgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  504
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, I22L, N31G ECD

<400>  504
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtatgcatgt       60

ctgccttgcc aactgcgctg ttcaagtggt acccccccgt tgacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  505
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, I22V, Q25M, N31P, T36M ECD

<400>  505
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

gttccttgca tgctgcgctg ttcaagccct acccccccgt tgatgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  506
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19Y, N31L, L35Y, T36S ECD

<400>  506
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtatgcatgt       60

attccttgcc agctgcgctg ttcaagcttg acccccccgt atagttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  507
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, S30G, N31H, L35A ECD

<400>  507
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gttggcatgt       60

attccttgcc aactgcgctg ttcaggtcat acccccccgg ctacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  508
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, Q25S, N31V, L35S, T36V ECD

<400>  508
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gttggcatgt       60

attccttgca gtctgcgctg ttcaagcgtt acccccccga gtgtgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  509
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, Q25S, S30Y, N31G, L35M, T36V ECD

<400>  509
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gttggcatgt       60

attccttgca gtctgcgctg ttcatatggg acccccccga tggtgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  510
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31L, L35Y, T36S ECD

<400>  510
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgct ttctgcgctg ttcaagcttg acccccccgt atagttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  511
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31S, T36G ECD

<400>  511
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgct ttctgcgctg ttcaagctct acccccccgc tgggttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  512
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, I22V, Q25S, N31V, L35S, T36V ECD

<400>  512
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

gttccttgct ctctgcgctg ttcaagcgtt acccccccga gtgtgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  513
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BMCA H19F, Q25G, N31S, L35V, T36N ECD

<400>  513
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgcg gtctgcgctg ttcaagctcg acccccccgg ttaattgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  514
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19L, Q25H, N31D, L35S ECD

<400>  514
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gttggcatgt       60

attccttgcc atctgcgctg ttcaagcgat acccccccgt ctacgtgtca gcagtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  515
<211>  159
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA H19F, Q25F, N31S, L35Y, T36S ECD

<400>  515
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gtttgcatgt       60

attccttgct ttctgcgctg ttcaagctct acccccccgt atagttgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcg                             159


<210>  516
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI WT ECD

<400>  516

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  517
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82P ECD

<400>  517

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Pro Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  518
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI D85E, K98T ECD

<400>  518

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Glu Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Thr Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  519
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI I87L, K98T ECD

<400>  519

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Leu Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Thr Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  520
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R60G, Q75E, L82P ECD

<400>  520

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Gly 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Glu Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Pro Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  521
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R60G, C86Y ECD

<400>  521

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Gly 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Tyr Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  522
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI A101D ECD

<400>  522

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Asp Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  523
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI C86Y ECD

<400>  523

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Tyr Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  524
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI W40R, L82P, F103Y ECD

<400>  524

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Arg Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Pro Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Tyr Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  525
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI W40R, Q59R, T61P, K98T ECD

<400>  525

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Arg Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Arg Arg 
            20                  25                  30          


Pro Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Thr Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  526
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82P, I87L ECD

<400>  526

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Pro Leu Arg Asp Cys Leu Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  527
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI G76S, P97S ECD

<400>  527

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Ser 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Ser Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  528
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI WT ECD

<400>  528

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  529
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI D85V ECD

<400>  529

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Val Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  530
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI E74V ECD

<400>  530

Ser Leu Ser Cys Arg Lys Val Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  531
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84L ECD

<400>  531

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Leu Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  532
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, R84L, F103Y ECD

<400>  532

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Leu Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Tyr Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  533
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Y79F, Q99E ECD

<400>  533

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Phe Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Glu 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  534
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Y79F ECD

<400>  534

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Phe Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  535
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84G ECD

<400>  535

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gly Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  536
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L83S, F103S ECD

<400>  536

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Ser Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Ser Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  537
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82H ECD

<400>  537

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His His Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  538
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI A101D ECD

<400>  538

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  539
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, R84Q ECD

<400>  539

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  540
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, A101D ECD

<400>  540

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  541
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, F78Y, Y102D ECD

<400>  541

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  542
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Q75E, R84Q ECD

<400>  542

Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  543
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Q75R, R84G, I92V ECD

<400>  543

Ser Leu Ser Cys Arg Lys Glu Arg Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gly Asp Cys Ile Ser Cys Ala Ser Val Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  544
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, A101D, Y102D ECD

<400>  544

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  545
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q ECD

<400>  545

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  546
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q, S88N, A101D ECD

<400>  546

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Asn Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  547
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E ECD

<400>  547

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  548
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q, F103V ECD

<400>  548

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Val Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  549
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, Q95R, A101D ECD

<400>  549

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Arg His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  550
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI I87M, A101D ECD

<400>  550

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Met Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  551
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI WT ECD

<400>  551
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga ctgtataagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  552
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82P ECD

<400>  552
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ctttgcgaga ctgtataagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  553
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI D85E, K98T ECD

<400>  553
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga atgtataagc      180

tgtgcgtcta tttgtggaca acaccctaca caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  554
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI I87L, K98T ECD

<400>  554
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga ctgtttaagc      180

tgtgcgtcta tttgtggaca acaccctaca caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  555
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R60G, Q75E, L82P ECD

<400>  555
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caagggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagga aggcaaattt tacgaccatc ctttgcgaga ctgtataagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  556
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R60G, C86Y ECD

<400>  556
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caagggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga ctacataagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  557
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI A101D ECD

<400>  557
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga ctgtataagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgatt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  558
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI C86Y ECD

<400>  558
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga ctatataagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  559
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI W40R, L82P, F103Y ECD

<400>  559
gtggcaatgc gctcatgccc agaggaacaa tatcgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ctttgcgaga ctgtataagc      180

tgtgcgtcta tttgtggtca acaccctaaa caatgtgctt attactgtga aaataagctt      240

cgatct                                                                 246


<210>  560
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI W40R, Q59R, T61P, K98T ECD

<400>  560
gtggcaatgc gctcatgccc agaggaacaa tatcgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc cgaaggccat gcgcagcatt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga ctgtataagc      180

tgtgcgtcta tttgtggaca acaccctaca caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  561
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82P, I87L ECD

<400>  561
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ctttgcgaga ctgtttaagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  562
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI G76S, P97S ECD

<400>  562
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aagcaaattt tacgaccatc ttttgcgaga ctgtataagc      180

tgtgcgtcta tttgtggtca acactctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  563
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI WT ECD

<400>  563
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  564
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI D85V ECD

<400>  564
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttgcg agtctgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  565
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI E74V ECD

<400>  565
agtctctctt gcaggaaagt gcaaggcaaa ttttacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  566
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84L ECD

<400>  566
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttgct agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  567
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, R84L, F103Y ECD

<400>  567
agtctctctt gcaggaaaga gcaaggcgaa ttttacgacc atcttttgct agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttattactg tgaaaataag      120

cttcgatct                                                              129


<210>  568
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Y79F, Q99E ECD

<400>  568
agtctctctt gcaggaaaga gcaaggcaaa tttttcgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaagaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  569
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Y79F ECD

<400>  569
agtctctctt gcaggaaaga gcaaggcaaa tttttcgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  570
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84G ECD

<400>  570
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttggg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  571
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L83S, F103S ECD

<400>  571
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc tttcgcgaga ctgtataagc      180

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt attcctgtga aaataagctt      240

cgatct                                                                 246


<210>  572
<211>  246
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82H ECD

<400>  572
gtggcaatgc gctcatgccc agaggaacaa tattgggatc cgcttcttgg gacgtgtatg       60

agctgcaaga ccatctgtaa tcatcaatcc caaaggacat gcgcagcttt ctgcaggagt      120

ctctcttgca ggaaagagca aggcaaattt tacgaccatc atttgcgaga ctgtataagc      180

tgtgcgtcta tctgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt      240

cgatct                                                                 246


<210>  573
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI A101D ECD

<400>  573
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg attatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  574
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, R84Q ECD

<400>  574
agtctctctt gcaggaaaga gcaaggcgaa ttttacgacc atcttttgca agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  575
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, A101D ECD

<400>  575
agtctctctt gcaggaaaga gcaaggcgaa ttttacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg attatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  576
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, F78Y, Y102D ECD

<400>  576
agtctctctt gcaggaaaga gcaaggcgaa tattacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg ctgatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  577
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Q75E, R84Q ECD

<400>  577
agtctctctt gcaggaaaga ggaaggcaaa ttttacgacc atcttttgca agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  578
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Q75R, R84G, I92V ECD

<400>  578
agtctctctt gcaggaaaga gcgaggcaaa ttttacgacc atcttttggg agactgtata       60

agctgtgcgt ctgtttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  579
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, A101D, Y102D ECD

<400>  579
agtctctctt gcaggaaaga gcaaggcgaa ttttacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg atgatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  580
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q ECD

<400>  580
agtctctctt gcaggaaaga gcaaggcaaa ttttatgacc atcttttgca agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  581
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q, S88N, A101D ECD

<400>  581
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttgca agactgtata       60

aactgtgcgt ctatatgtgg acaacaccct aaacaatgtg attatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  582
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E ECD

<400>  582
agtctctctt gcaggaaaga gcaaggcgaa ttttacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  583
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q, F103V ECD

<400>  583
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttgca agactgtata       60

agctgtgcgt ctatttgtgg acaacaccct aaacaatgtg cttatgtctg tgaaaataag      120

cttcgatct                                                              129


<210>  584
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, Q95R, A101D ECD

<400>  584
agtctctctt gcaggaaaga gcaaggcgaa ttttacgacc atcttttgcg agactgtata       60

agctgtgcgt ctatttgtgg acgacaccct aaacaatgtg attatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  585
<211>  129
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI I87M, A101D ECD

<400>  585
agtctctctt gcaggaaaga gcaaggcaaa ttttacgacc atcttttgcg agactgtatg       60

agctgtgcgt caatttgtgg acaacaccct aaacaatgtg attatttctg tgaaaataag      120

cttcgatct                                                              129


<210>  586
<211>  232
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  IgG1 Fc

<400>  586

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  587
<211>  224
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CD86 ECD (24-247)

<400>  587

Ala Pro Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro 
1               5                   10                  15      


Cys Gln Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val 
            20                  25                  30          


Phe Trp Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly 
        35                  40                  45              


Lys Glu Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser 
    50                  55                  60                  


Phe Asp Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys 
65                  70                  75                  80  


Asp Lys Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Gly 
                85                  90                  95      


Met Ile Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn 
            100                 105                 110         


Phe Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ile Thr Glu Asn Val 
        115                 120                 125             


Tyr Ile Asn Leu Thr Cys Ser Ser Ile His Gly Tyr Pro Glu Pro Lys 
    130                 135                 140                 


Lys Met Ser Val Leu Leu Arg Thr Lys Asn Ser Thr Ile Glu Tyr Asp 
145                 150                 155                 160 


Gly Val Met Gln Lys Ser Gln Asp Asn Val Thr Glu Leu Tyr Asp Val 
                165                 170                 175     


Ser Ile Ser Leu Ser Val Ser Phe Pro Asp Val Thr Ser Asn Met Thr 
            180                 185                 190         


Ile Phe Cys Ile Leu Glu Thr Asp Lys Thr Arg Leu Leu Ser Ser Pro 
        195                 200                 205             


Phe Ser Ile Glu Leu Glu Asp Pro Gln Pro Pro Pro Asp His Ile Pro 
    210                 215                 220                 


<210>  588
<211>  8
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FLAG-tag

<400>  588

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  589
<211>  231
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc C220S/L234A/L235E/G237A/K447del

<400>  589

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  590
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker

<400>  590

Gly Ser Gly Gly Gly Gly Ser 
1               5           


<210>  591
<211>  232
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc C220S/L234A/L235E/G237A/E356D/M358L

<400>  591

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  592
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Linker

<400>  592

Gly Ser Gly Gly Ser 
1               5   


<210>  593
<211>  5
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LINKER

<400>  593

Gly Gly Gly Gly Ser 
1               5   


<210>  594
<211>  10
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LINKER

<400>  594

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  595
<211>  15
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LINKER

<400>  595

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  596
<211>  7
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LINKER

<400>  596

Gly Gly Gly Gly Ser Ser Ala 
1               5           


<210>  597
<211>  231
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc (E356D and M358L)

<400>  597

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  598
<211>  232
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc (C5S (C220S), R77C, (R292C),  N82G (N297G), V87C (V302C))

<400>  598

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  599
<211>  232
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc with C220S/L234A/L235E/G237A

<400>  599

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  600
<211>  20
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LINKER

<400>  600

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  601
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 186 GSG4S  Fc- (G4S)4  BCMA 406

<400>  601

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  602
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)4 BCMA 406

<400>  602

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  603
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 186GSG4S Fc- (G4S)4  BCMA 381

<400>  603

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ala Leu 
385                 390                 395                 400 


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  604
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 186GSG4S  Fc- (G4S)4  BCMA 411

<400>  604

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Arg Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  605
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 186GSG4S  Fc- (G4S)4 BCMA 405

<400>  605

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Lys Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  606
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)4 BCMA 381

<400>  606

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ala Leu 
385                 390                 395                 400 


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  607
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)4 BCMA 411

<400>  607

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Arg Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  608
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)4 BCMA 405

<400>  608

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Lys Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  609
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 381 GSG4S Fc- (G4S)4 CTLA4 186

<400>  609

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ala Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  610
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 186 GSG4S Fc (G4S)4 TACI 541

<400>  610

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu 
385                 390                 395                 400 


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  611
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)4 TACI 541

<400>  611

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu 
385                 390                 395                 400 


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  612
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 186 GSG4S Fc (G4S)4 (TACI 542

<400>  612

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
385                 390                 395                 400 


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  613
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)4 (TACI 542

<400>  613

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
385                 390                 395                 400 


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  614
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 542 GSG4S Fc (G4S)4 (CTLA4 186

<400>  614

Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            180                 185                 190         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met 
    290                 295                 300                 


His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
305                 310                 315                 320 


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
                325                 330                 335     


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
            340                 345                 350         


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
        355                 360                 365             


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
    370                 375                 380                 


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
385                 390                 395                 400 


Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr 
                405                 410                 415     


Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
            420                 425         


<210>  615
<211>  460
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 516 (G4S)2 Fc (G4S)2 CTLA 4 668

<400>  615

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
                85                  90                  95      


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
            100                 105                 110         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        115                 120                 125             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    130                 135                 140                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
145                 150                 155                 160 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                165                 170                 175     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    210                 215                 220                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
225                 230                 235                 240 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                245                 250                 255     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            260                 265                 270         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        275                 280                 285             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    290                 295                 300                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
305                 310                 315                 320 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met 
                325                 330                 335     


His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
            340                 345                 350         


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
        355                 360                 365             


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
    370                 375                 380                 


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
385                 390                 395                 400 


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
                405                 410                 415     


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
            420                 425                 430         


Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr 
        435                 440                 445             


Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln 
    450                 455                 460 


<210>  616
<211>  421
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (G4S)2 Fc (G4S)2 CTLA 4 WT ECD 1

<400>  616

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    50                  55                  60                  


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
65                  70                  75                  80  


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                85                  90                  95      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            100                 105                 110         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        115                 120                 125             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    130                 135                 140                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
145                 150                 155                 160 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                165                 170                 175     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            180                 185                 190         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        195                 200                 205             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    210                 215                 220                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
225                 230                 235                 240 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                245                 250                 255     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            260                 265                 270         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val 
    290                 295                 300                 


Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala 
305                 310                 315                 320 


Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala 
                325                 330                 335     


Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn 
            340                 345                 350         


Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly 
        355                 360                 365             


Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly 
    370                 375                 380                 


Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu 
385                 390                 395                 400 


Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys 
                405                 410                 415     


Pro Asp Ser Asp Gln 
            420     


<210>  617
<211>  421
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (G4S)2 Fc (G4S)2 CTLA 4 668

<400>  617

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    50                  55                  60                  


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
65                  70                  75                  80  


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                85                  90                  95      


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            100                 105                 110         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        115                 120                 125             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    130                 135                 140                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
145                 150                 155                 160 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                165                 170                 175     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            180                 185                 190         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        195                 200                 205             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    210                 215                 220                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
225                 230                 235                 240 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                245                 250                 255     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            260                 265                 270         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala Val 
    290                 295                 300                 


Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala 
305                 310                 315                 320 


Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala 
                325                 330                 335     


Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn 
            340                 345                 350         


Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly 
        355                 360                 365             


Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly 
    370                 375                 380                 


Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu 
385                 390                 395                 400 


Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser 
                405                 410                 415     


Pro Asp Ser Asp Gln 
            420     


<210>  618
<211>  253
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 516  (EAAAK)6 CTLA 4 WT ECD 1

<400>  618

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                85                  90                  95      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            100                 105                 110         


Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
        115                 120                 125             


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
    130                 135                 140                 


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
145                 150                 155                 160 


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
                165                 170                 175     


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
            180                 185                 190         


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
        195                 200                 205             


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
    210                 215                 220                 


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  619
<211>  253
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 516  (EAAAK)6 CTLA 4 668

<400>  619

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                85                  90                  95      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            100                 105                 110         


Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
        115                 120                 125             


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
    130                 135                 140                 


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
145                 150                 155                 160 


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
                165                 170                 175     


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
            180                 185                 190         


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
        195                 200                 205             


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
    210                 215                 220                 


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
                245                 250             


<210>  620
<211>  214
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (EAAAK)6 CTLA 4 WT ECD 1

<400>  620

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Glu Ala Ala Ala Lys 
        35                  40                  45              


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    50                  55                  60                  


Ala Ala Ala Lys Glu Ala Ala Ala Lys Lys Ala Met His Val Ala Gln 
65                  70                  75                  80  


Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys 
                85                  90                  95      


Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu 
            100                 105                 110         


Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met 
        115                 120                 125             


Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr 
    130                 135                 140                 


Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met 
145                 150                 155                 160 


Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro 
                165                 170                 175     


Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro 
            180                 185                 190         


Glu Pro Cys Pro Asp Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
        195                 200                 205             


His His His His His His 
    210                 


<210>  621
<211>  214
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (EAAAK)6 CTLA 4 668

<400>  621

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Glu Ala Ala Ala Lys 
        35                  40                  45              


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    50                  55                  60                  


Ala Ala Ala Lys Glu Ala Ala Ala Lys Lys Ala Met His Val Ala Gln 
65                  70                  75                  80  


Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys 
                85                  90                  95      


Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu 
            100                 105                 110         


Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met 
        115                 120                 125             


Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr 
    130                 135                 140                 


Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met 
145                 150                 155                 160 


Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro 
                165                 170                 175     


Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro 
            180                 185                 190         


Glu Pro Ser Pro Asp Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
        195                 200                 205             


His His His His His His 
    210                 


<210>  622
<211>  238
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 516  (G4S)3 CTLA 4 668

<400>  622

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                85                  90                  95      


Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser 
            100                 105                 110         


Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala 
        115                 120                 125             


Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr 
    130                 135                 140                 


Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu 
145                 150                 155                 160 


Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu 
                165                 170                 175     


Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys 
            180                 185                 190         


Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly 
        195                 200                 205             


Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln 
    210                 215                 220                 


Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235             


<210>  623
<211>  199
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (G4S)3 CTLA 4 668

<400>  623

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala 
    50                  55                  60                  


Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val 
65                  70                  75                  80  


Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val 
                85                  90                  95      


Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr 
            100                 105                 110         


Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly 
        115                 120                 125             


Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala 
    130                 135                 140                 


Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro 
145                 150                 155                 160 


Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp 
                165                 170                 175     


Pro Glu Pro Ser Pro Asp Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp 
            180                 185                 190         


Lys His His His His His His 
        195                 


<210>  624
<211>  460
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 (G4S)2 Fc (G4S)2 TACI 516

<400>  624

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys 
    370                 375                 380                 


Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys 
385                 390                 395                 400 


Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys 
                405                 410                 415     


Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu 
            420                 425                 430         


Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys 
        435                 440                 445             


Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455                 460 


<210>  625
<211>  460
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA 4 668 (G4S)2 Fc (G4S)2 TACI 516

<400>  625

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys 
    370                 375                 380                 


Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys 
385                 390                 395                 400 


Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys 
                405                 410                 415     


Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu 
            420                 425                 430         


Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys 
        435                 440                 445             


Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455                 460 


<210>  626
<211>  421
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 (G4S)2 Fc (G4S)2 TACI 528

<400>  626

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser Cys Arg Lys 
    370                 375                 380                 


Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys 
385                 390                 395                 400 


Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu 
                405                 410                 415     


Asn Lys Leu Arg Ser 
            420     


<210>  627
<211>  421
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA 4 668 (G4S)2 Fc (G4S)2 TACI 528

<400>  627

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser Cys Arg Lys 
    370                 375                 380                 


Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys 
385                 390                 395                 400 


Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu 
                405                 410                 415     


Asn Lys Leu Arg Ser 
            420     


<210>  628
<211>  294
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc (G4S)2 BCMA (356)

<400>  628

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
                245                 250                 255     


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            260                 265                 270         


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        275                 280                 285             


Val Lys Gly Thr Asn Ala 
    290                 


<210>  629
<211>  294
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc (G4S)2 BCMA (357)

<400>  629

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
                245                 250                 255     


Leu Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            260                 265                 270         


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        275                 280                 285             


Val Lys Gly Thr Asn Ala 
    290                 


<210>  630
<211>  323
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc (G4S)2 TACI (516)

<400>  630

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu 
                245                 250                 255     


Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln 
            260                 265                 270         


Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln 
        275                 280                 285             


Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser 
    290                 295                 300                 


Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys 
305                 310                 315                 320 


Leu Arg Ser 
            


<210>  631
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)2 BCMA 356

<400>  631

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn 
    370                 375                 380                 


Glu Tyr Phe Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg 
385                 390                 395                 400 


Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala 
                405                 410                 415     


Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
            420                 425         


<210>  632
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 92 GSG4S Fc (G4S)2 BCMA 356

<400>  632

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn 
    370                 375                 380                 


Glu Tyr Phe Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg 
385                 390                 395                 400 


Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala 
                405                 410                 415     


Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
            420                 425         


<210>  633
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 165 GSG4S Fc (G4S)2 BCMA 356

<400>  633

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn 
    370                 375                 380                 


Glu Tyr Phe Asp Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg 
385                 390                 395                 400 


Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala 
                405                 410                 415     


Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
            420                 425         


<210>  634
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD 1 GSG4S Fc (G4S)2 BCMA 357

<400>  634

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn 
    370                 375                 380                 


Glu Tyr Phe Asp Ser Leu Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg 
385                 390                 395                 400 


Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala 
                405                 410                 415     


Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
            420                 425         


<210>  635
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 92 GSG4S Fc (G4S)2 BCMA 357

<400>  635

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn 
    370                 375                 380                 


Glu Tyr Phe Asp Ser Leu Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg 
385                 390                 395                 400 


Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala 
                405                 410                 415     


Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
            420                 425         


<210>  636
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 165 GSG4S Fc (G4S)2 BCMA 357

<400>  636

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn 
    370                 375                 380                 


Glu Tyr Phe Asp Ser Leu Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg 
385                 390                 395                 400 


Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala 
                405                 410                 415     


Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
            420                 425         


<210>  637
<211>  456
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA 4 92 GSG4S Fc (G4S)2 TACI 516

<400>  637

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys Pro Glu Glu Gln 
    370                 375                 380                 


Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys 
385                 390                 395                 400 


Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser 
                405                 410                 415     


Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys 
            420                 425                 430         


Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr 
        435                 440                 445             


Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455     


<210>  638
<211>  456
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA 4 165 GSG4S Fc (G4S)2 TACI 516

<400>  638

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys Pro Glu Glu Gln 
    370                 375                 380                 


Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys 
385                 390                 395                 400 


Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser 
                405                 410                 415     


Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys 
            420                 425                 430         


Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr 
        435                 440                 445             


Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455     


<210>  639
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 92 GSG4S Fc K (G4S)4 BCMA 357

<400>  639

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  640
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 92 GSG4S Fc K (G4S)4 TACI 528

<400>  640

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
385                 390                 395                 400 


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  641
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 113 GSG4S Fc K (G4S)4 BCMA 357

<400>  641

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
385                 390                 395                 400 


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
                405                 410                 415     


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
            420                 425                 430         


Lys Gly Thr Asn Ala 
        435         


<210>  642
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 113 GSG4S Fc H (G4S)4 TACI 528

<400>  642

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Val Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
385                 390                 395                 400 


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  643
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 113 GSG4S Fc (G4S)4 TACI 535 (68-110)

<400>  643

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
385                 390                 395                 400 


Gly Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  644
<211>  466
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 113 GSG4S Fc (G4S)4 TACI 535 (29-110)

<400>  644

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
385                 390                 395                 400 


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
                405                 410                 415     


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
            420                 425                 430         


Lys Phe Tyr Asp His Leu Leu Gly Asp Cys Ile Ser Cys Ala Ser Ile 
        435                 440                 445             


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
    450                 455                 460                 


Arg Ser 
465     


<210>  645
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 411 GSG4S Fc (G4S)4 CTLA4 186

<400>  645

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Arg Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  646
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 405 GSG4S Fc (G4S)4 CTLA4 186

<400>  646

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Lys Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  647
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 406 GSG4S Fc (G4S)4 CTLA4 186

<400>  647

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  648
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 541 GSG4S Fc (G4S)4 CTLA4 186

<400>  648

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            180                 185                 190         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met 
    290                 295                 300                 


His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
305                 310                 315                 320 


Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg 
                325                 330                 335     


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
            340                 345                 350         


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
        355                 360                 365             


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
    370                 375                 380                 


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met 
385                 390                 395                 400 


Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr 
                405                 410                 415     


Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
            420                 425         


<210>  649
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 381 GSG4S Fc (G4S)4 CTLA4 WT ECD 1

<400>  649

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ala Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  650
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 411 GSG4S Fc (G4S)4 CTLA4 WT ECD 1

<400>  650

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Arg Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  651
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 405 GSG4S Fc (G4S)4 CTLA4 WT ECD 1

<400>  651

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Lys Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  652
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 406 GSG4S Fc (G4S)4 CTLA4 WT ECD 1

<400>  652

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  653
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 541 GSG4S Fc (G4S)4 CTLA4 WT ECD 1

<400>  653

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            180                 185                 190         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met 
    290                 295                 300                 


His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
305                 310                 315                 320 


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
                325                 330                 335     


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
            340                 345                 350         


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
        355                 360                 365             


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
    370                 375                 380                 


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
385                 390                 395                 400 


Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr 
                405                 410                 415     


Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
            420                 425         


<210>  654
<211>  427
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 542 GSG4S Fc (G4S)4 CTLA4 WT ECD 1

<400>  654

Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
    50                  55                  60                  


Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 
65                  70                  75                  80  


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                85                  90                  95      


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
            100                 105                 110         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        115                 120                 125             


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    130                 135                 140                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
145                 150                 155                 160 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                165                 170                 175     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
            180                 185                 190         


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        195                 200                 205             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    210                 215                 220                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
225                 230                 235                 240 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
                245                 250                 255     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            260                 265                 270         


Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met 
    290                 295                 300                 


His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
305                 310                 315                 320 


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg 
                325                 330                 335     


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
            340                 345                 350         


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
        355                 360                 365             


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
    370                 375                 380                 


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
385                 390                 395                 400 


Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr 
                405                 410                 415     


Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
            420                 425         


<210>  655
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 357 (G4S)3 CTLA4 92 GSG4S Fc

<400>  655

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln 
65                  70                  75                  80  


Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys 
                85                  90                  95      


Glu Tyr Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr Val Leu 
            100                 105                 110         


Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met 
        115                 120                 125             


Met Gly Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile Cys Thr Gly Thr 
    130                 135                 140                 


Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Arg Gly Leu Arg Ala Met 
145                 150                 155                 160 


Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro Pro Pro 
                165                 170                 175     


Tyr Leu Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro 
            180                 185                 190         


Glu Pro Cys Pro Asp Ser Asp Gly Ser Gly Gly Gly Gly Ser Glu Pro 
        195                 200                 205             


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    210                 215                 220                 


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            260                 265                 270         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        275                 280                 285             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                325                 330                 335     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            340                 345                 350         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        355                 360                 365             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    370                 375                 380                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
385                 390                 395                 400 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                405                 410                 415     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly 
        435         


<210>  656
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA 357 GSG4S Fc (G4S)3 CTLA4 92

<400>  656

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala Gln Pro Ala 
305                 310                 315                 320 


Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr 
                325                 330                 335     


Ala Ser Pro Trp Lys Ala Thr Glu Val Arg Val Thr Val Leu Arg Gln 
            340                 345                 350         


Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met Met Gly 
        355                 360                 365             


Ser Glu Leu Thr Phe Pro Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser 
    370                 375                 380                 


Gly Asn Gln Val Asn Leu Thr Ile Arg Gly Leu Arg Ala Met Asp Thr 
385                 390                 395                 400 


Gly Leu Tyr Ile Cys Lys Val Glu Gln Met Tyr Pro Pro Pro Tyr Leu 
                405                 410                 415     


Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro 
            420                 425                 430         


Cys Pro Asp Ser Asp 
        435         


<210>  657
<211>  437
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 92 (G4S)4 BCMA 357  GSG4S Fc

<400>  657

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp 
145                 150                 155                 160 


Ser Leu Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn 
                165                 170                 175     


Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn 
            180                 185                 190         


Ser Val Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro 
        195                 200                 205             


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
    210                 215                 220                 


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            260                 265                 270         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        275                 280                 285             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                325                 330                 335     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            340                 345                 350         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        355                 360                 365             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    370                 375                 380                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
385                 390                 395                 400 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                405                 410                 415     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly 
        435         


<210>  658
<211>  432
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 92 GSG4S Fc (G4S)3 BCMA 357

<400>  658

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Gln Met Ala Gly 
    370                 375                 380                 


Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu Tyr Ala Cys Ile 
385                 390                 395                 400 


Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln 
                405                 410                 415     


Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
            420                 425                 430         


<210>  659
<211>  442
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 92 GSG4S Fc (G4S)5 BCMA 357

<400>  659

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu 
385                 390                 395                 400 


Tyr Phe Asp Ser Leu Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys 
                405                 410                 415     


Ser Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser 
            420                 425                 430         


Val Thr Asn Ser Val Lys Gly Thr Asn Ala 
        435                 440         


<210>  660
<211>  291
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  BCMA (357) GSG4S Fc H

<400>  660

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly 
    290     


<210>  661
<211>  294
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc (G4S)4 TACI (541)

<400>  661

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser Cys Arg 
                245                 250                 255     


Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu Arg Asp Cys Ile Ser 
            260                 265                 270         


Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Asp Phe Cys 
        275                 280                 285             


Glu Asn Lys Leu Arg Ser 
    290                 


<210>  662
<211>  364
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 (92) GSG4S Fc K

<400>  662

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 


<210>  663
<211>  364
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 (113)  GSG4S FcK

<400>  663

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 


<210>  664
<211>  510
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 (92) GSG4S Fc K (G4S)4 (92)

<400>  664

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
385                 390                 395                 400 


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
                405                 410                 415     


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
            420                 425                 430         


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
        435                 440                 445             


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
    450                 455                 460                 


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
465                 470                 475                 480 


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
                485                 490                 495     


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
            500                 505                 510 


<210>  665
<211>  30
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LINKER

<400>  665

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25                  30  


<210>  666
<211>  293
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FULL LENGTH TACI

<400>  666

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr Leu Gly Leu Cys Leu Cys Ala Val Leu Cys 
                165                 170                 175     


Cys Phe Leu Val Ala Val Ala Cys Phe Leu Lys Lys Arg Gly Asp Pro 
            180                 185                 190         


Cys Ser Cys Gln Pro Arg Ser Arg Pro Arg Gln Ser Pro Ala Lys Ser 
        195                 200                 205             


Ser Gln Asp His Ala Met Glu Ala Gly Ser Pro Val Ser Thr Ser Pro 
    210                 215                 220                 


Glu Pro Val Glu Thr Cys Ser Phe Cys Phe Pro Glu Cys Arg Ala Pro 
225                 230                 235                 240 


Thr Gln Glu Ser Ala Val Thr Pro Gly Thr Pro Asp Pro Thr Cys Ala 
                245                 250                 255     


Gly Arg Trp Gly Cys His Thr Arg Thr Thr Val Leu Gln Pro Cys Pro 
            260                 265                 270         


His Ile Pro Asp Ser Gly Leu Gly Ile Val Cys Val Pro Ala Gln Glu 
        275                 280                 285             


Gly Gly Pro Gly Ala 
    290             


<210>  667
<211>  184
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  FULL LENGTH BCMA

<400>  667

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala Ile Leu Trp Thr Cys Leu Gly Leu Ser Leu 
    50                  55                  60                  


Ile Ile Ser Leu Ala Val Phe Val Leu Met Phe Leu Leu Arg Lys Ile 
65                  70                  75                  80  


Asn Ser Glu Pro Leu Lys Asp Glu Phe Lys Asn Thr Gly Ser Gly Leu 
                85                  90                  95      


Leu Gly Met Ala Asn Ile Asp Leu Glu Lys Ser Arg Thr Gly Asp Glu 
            100                 105                 110         


Ile Ile Leu Pro Arg Gly Leu Glu Tyr Thr Val Glu Glu Cys Thr Cys 
        115                 120                 125             


Glu Asp Cys Ile Lys Ser Lys Pro Lys Val Asp Ser Asp His Cys Phe 
    130                 135                 140                 


Pro Leu Pro Ala Met Glu Glu Gly Ala Thr Ile Leu Val Thr Thr Lys 
145                 150                 155                 160 


Thr Asn Asp Tyr Cys Lys Ser Leu Pro Ala Ala Leu Ser Ala Thr Glu 
                165                 170                 175     


Ile Glu Lys Ser Ile Ser Ala Arg 
            180                 


<210>  668
<211>  126
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 WT ECD C122S

<400>  668

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp 
        115                 120                 125     


<210>  669
<211>  230
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc K S139C, D141E, L143M, T151W

<400>  669

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro 
225                 230 


<210>  670
<211>  230
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  Fc H Y134C, D141E, L143M, T151S, L153A

<400>  670

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro 
225                 230 


<210>  671
<211>  25
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  LINKER

<400>  671

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210>  672
<211>  126
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 A31Y/L106E

<400>  672

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp 
        115                 120                 125     


<210>  673
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82P ECD

<400>  673

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Pro Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  674
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI D85E, K98T ECD

<400>  674

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Glu Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Thr Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  675
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI I87L, K98T ECD

<400>  675

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Leu Ser Cys Ala Ser Ile Cys Gly Gln His Pro Thr Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  676
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI A101D ECD

<400>  676

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  677
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI C86Y ECD

<400>  677

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Tyr Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  678
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82P, I87L ECD

<400>  678

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Pro Leu 
1               5                   10                  15      


Arg Asp Cys Leu Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  679
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI G76S, P97S ECD

<400>  679

Ser Leu Ser Cys Arg Lys Glu Gln Ser Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Ser Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  680
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L83S, F103S ECD

<400>  680

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Ser 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Ser Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  681
<211>  43
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI L82H ECD

<400>  681

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His His Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  682
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI D85V ECD

<400>  682

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Val Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  683
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI E74V ECD

<400>  683

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Val Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  684
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84L ECD

<400>  684

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Leu Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  685
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, R84L, F103Y ECD

<400>  685

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Glu Phe Tyr Asp His Leu Leu Leu Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Tyr Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  686
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Y79F, Q99E ECD

<400>  686

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Phe Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Glu Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  687
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Y79F ECD

<400>  687

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Phe Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  688
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84G ECD

<400>  688

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Gly Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  689
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI A101D ECD

<400>  689

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Asp Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  690
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, R84Q ECD

<400>  690

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Glu Phe Tyr Asp His Leu Leu Gln Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  691
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, A101D ECD

<400>  691

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Glu Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Asp Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  692
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, F78Y, Y102D ECD

<400>  692

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Glu Tyr Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Asp Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  693
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Q75E, R84Q ECD

<400>  693

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Glu Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Gln Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  694
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI Q75R, R84G, I92V ECD

<400>  694

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Arg Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Gly Asp Cys Ile Ser Cys Ala Ser Val 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  695
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, A101D, Y102D ECD

<400>  695

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Glu Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Asp Asp Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  696
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q ECD

<400>  696

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Gln Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  697
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q, S88N, A101D ECD

<400>  697

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Gln Asp Cys Ile Asn Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Asp Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  698
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E ECD

<400>  698

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Glu Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  699
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI R84Q, F103V ECD

<400>  699

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Gln Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Val Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  700
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI K77E, Q95R, A101D ECD

<400>  700

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Glu Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Arg His Pro Lys Gln Cys Asp Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  701
<211>  82
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI I87M, A101D ECD

<400>  701

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Met Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Asp Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser 
        


<210>  702
<211>  660
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  CTLA4 113 GSG4S Fc K/ BCMA 357 GSG4S Fc H

<400>  702

Lys Ala Met His Val Ala Gln Pro Ala Val Val Phe Ala Ser Ser His 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Thr Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys 
            260                 265                 270         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Gln Met Ala 
        355                 360                 365             


Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu Leu Tyr Ala Cys 
    370                 375                 380                 


Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro Pro Leu Thr Cys 
385                 390                 395                 400 


Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val Lys Gly Thr Asn 
                405                 410                 415     


Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Ser Glu Pro 
            420                 425                 430         


Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        435                 440                 445             


Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    450                 455                 460                 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
465                 470                 475                 480 


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                485                 490                 495     


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            500                 505                 510         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        515                 520                 525             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    530                 535                 540                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
545                 550                 555                 560 


Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                565                 570                 575     


Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            580                 585                 590         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        595                 600                 605             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val Ser Lys 
    610                 615                 620                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
625                 630                 635                 640 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                645                 650                 655     


Ser Leu Ser Pro 
            660 


<210>  703
<211>  247
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 516  (EAAAK)6 CTLA 4 WT ECD 1

<400>  703

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                85                  90                  95      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            100                 105                 110         


Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
        115                 120                 125             


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
    130                 135                 140                 


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
145                 150                 155                 160 


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
                165                 170                 175     


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
            180                 185                 190         


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
        195                 200                 205             


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
    210                 215                 220                 


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys 
                245         


<210>  704
<211>  247
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 516  (EAAAK)6 CTLA 4 668

<400>  704

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                85                  90                  95      


Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            100                 105                 110         


Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
        115                 120                 125             


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
    130                 135                 140                 


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
145                 150                 155                 160 


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
                165                 170                 175     


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
            180                 185                 190         


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
        195                 200                 205             


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
    210                 215                 220                 


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Asp 
225                 230                 235                 240 


Tyr Lys Asp Asp Asp Asp Lys 
                245         


<210>  705
<211>  208
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (EAAAK)6 CTLA 4 WT ECD 1

<400>  705

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Glu Ala Ala Ala Lys 
        35                  40                  45              


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    50                  55                  60                  


Ala Ala Ala Lys Glu Ala Ala Ala Lys Lys Ala Met His Val Ala Gln 
65                  70                  75                  80  


Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys 
                85                  90                  95      


Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu 
            100                 105                 110         


Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met 
        115                 120                 125             


Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr 
    130                 135                 140                 


Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met 
145                 150                 155                 160 


Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro 
                165                 170                 175     


Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro 
            180                 185                 190         


Glu Pro Cys Pro Asp Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
        195                 200                 205             


<210>  706
<211>  208
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (EAAAK)6 CTLA 4 668

<400>  706

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Glu Ala Ala Ala Lys 
        35                  40                  45              


Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
    50                  55                  60                  


Ala Ala Ala Lys Glu Ala Ala Ala Lys Lys Ala Met His Val Ala Gln 
65                  70                  75                  80  


Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val Cys 
                85                  90                  95      


Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val Leu 
            100                 105                 110         


Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr Met 
        115                 120                 125             


Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly Thr 
    130                 135                 140                 


Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala Met 
145                 150                 155                 160 


Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro Pro 
                165                 170                 175     


Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp Pro 
            180                 185                 190         


Glu Pro Ser Pro Asp Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp Lys 
        195                 200                 205             


<210>  707
<211>  232
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 516  (G4S)3 CTLA 4 668

<400>  707

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                85                  90                  95      


Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser 
            100                 105                 110         


Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala 
        115                 120                 125             


Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr 
    130                 135                 140                 


Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu 
145                 150                 155                 160 


Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu 
                165                 170                 175     


Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys 
            180                 185                 190         


Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly 
        195                 200                 205             


Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Ser Pro Asp Ser Asp Gln 
    210                 215                 220                 


Asp Tyr Lys Asp Asp Asp Asp Lys 
225                 230         


<210>  708
<211>  193
<212>  PRT
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  TACI 528  (G4S)3 CTLA 4 668

<400>  708

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met His Val Ala 
    50                  55                  60                  


Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser Phe Val 
65                  70                  75                  80  


Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr Glu Val Arg Val Thr Val 
                85                  90                  95      


Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala Thr Tyr 
            100                 105                 110         


Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys Thr Gly 
        115                 120                 125             


Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu Arg Ala 
    130                 135                 140                 


Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr Pro Pro 
145                 150                 155                 160 


Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val Ile Asp 
                165                 170                 175     


Pro Glu Pro Ser Pro Asp Ser Asp Gln Asp Tyr Lys Asp Asp Asp Asp 
            180                 185                 190         


Lys 
    


<210>  709
<211>  166
<212>  PRT
<213>  artificial sequence

<220>
<223>  TACI ECD (1-166)

<400>  709

Met Ser Gly Leu Gly Arg Ser Arg Arg Gly Gly Arg Ser Arg Val Asp 
1               5                   10                  15      


Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly Val Ala Met Arg 
            20                  25                  30          


Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met 
        35                  40                  45              


Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala 
    50                  55                  60                  


Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp 
65                  70                  75                  80  


His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His 
                85                  90                  95      


Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser Pro Val 
            100                 105                 110         


Asn Leu Pro Pro Glu Leu Arg Arg Gln Arg Ser Gly Glu Val Glu Asn 
        115                 120                 125             


Asn Ser Asp Asn Ser Gly Arg Tyr Gln Gly Leu Glu His Arg Gly Ser 
    130                 135                 140                 


Glu Ala Ser Pro Ala Leu Pro Gly Leu Lys Leu Ser Ala Asp Gln Val 
145                 150                 155                 160 


Ala Leu Val Tyr Ser Thr 
                165     


<210>  710
<211>  54
<212>  PRT
<213>  artificial sequence

<220>
<223>  BCMA ECD (1-54)

<400>  710

Met Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser 
1               5                   10                  15      


Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr 
            20                  25                  30          


Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser 
        35                  40                  45              


Val Lys Gly Thr Asn Ala 
    50                  


<210>  711
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  1xEAAAK

<400>  711

Glu Ala Ala Ala Lys 
1               5   


<210>  712
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  2xEAAAK

<400>  712

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10  


<210>  713
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  3xEAAAK

<400>  713

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys 
1               5                   10                  15  


<210>  714
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  4xEAAAK

<400>  714

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys 
            20  


<210>  715
<211>  25
<212>  PRT
<213>  artificial sequence

<220>
<223>  5xEAAAK

<400>  715

Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu 
1               5                   10                  15      


Ala Ala Ala Lys Glu Ala Ala Ala Lys 
            20                  25  


<210>  716
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  knob Fc

<400>  716

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Cys Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Trp Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  717
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  hole Fc

<400>  717

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Cys Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Ser Cys Ala Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Val 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  718
<211>  81
<212>  PRT
<213>  artificial sequence

<220>
<223>  atacicept (TACI portion, 30-110)

<400>  718

Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly 
1               5                   10                  15      


Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr 
            20                  25                  30          


Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys 
        35                  40                  45              


Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys 
    50                  55                  60                  


Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg 
65                  70                  75                  80  


Ser 
    


<210>  719
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  telitacicept (TACI portion, 13-118)

<400>  719

Ser Arg Val Asp Gln Glu Glu Arg Phe Pro Gln Gly Leu Trp Thr Gly 
1               5                   10                  15      


Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
            20                  25                  30          


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
        35                  40                  45              


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
    50                  55                  60                  


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
65                  70                  75                  80  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
                85                  90                  95      


Arg Ser Pro Val Asn Leu Pro Pro Glu Leu 
            100                 105     


<210>  720
<211>  313
<212>  PRT
<213>  artificial sequence

<220>
<223>  atacicept

<400>  720

Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly 
1               5                   10                  15      


Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr 
            20                  25                  30          


Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys 
        35                  40                  45              


Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys 
    50                  55                  60                  


Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg 
65                  70                  75                  80  


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                85                  90                  95      


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
            100                 105                 110         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        115                 120                 125             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    130                 135                 140                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
145                 150                 155                 160 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                165                 170                 175     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            180                 185                 190         


Ala Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        195                 200                 205             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    210                 215                 220                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
225                 230                 235                 240 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                245                 250                 255     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            260                 265                 270         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        275                 280                 285             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    290                 295                 300                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
305                 310             


<210>  721
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  721

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ala Ala Ala 
1               5                   10              


<210>  722
<211>  231
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc with C220S/E233P/L234V/L235A/G236del/S267K

<400>  722

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly Lys 
225                 230     


<210>  723
<211>  231
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc (C5S (C220S), R77C, (R292C),  N82G (N297G), V87C (V302C), 
       L232del (K447del))

<400>  723

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Cys Glu Glu Gln 
65                  70                  75                  80  


Tyr Gly Ser Thr Tyr Arg Cys Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  724
<211>  231
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc with C220S/L234A/L235E/G237A/K447del

<400>  724

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  725
<211>  230
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc with C220S/E233P/L234V/L235A/G236del/S267K/K447del

<400>  725

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
            20                  25                  30          


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
        35                  40                  45              


Asp Val Lys His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
    50                  55                  60                  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
65                  70                  75                  80  


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
                85                  90                  95      


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
            100                 105                 110         


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
        115                 120                 125             


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 
    130                 135                 140                 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
145                 150                 155                 160 


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
                165                 170                 175     


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
            180                 185                 190         


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
        195                 200                 205             


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
    210                 215                 220                 


Leu Ser Leu Ser Pro Gly 
225                 230 


<210>  726
<211>  235
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG2 Fc

<400>  726

Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
1               5                   10                  15      


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
            20                  25                  30          


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        35                  40                  45              


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
    50                  55                  60                  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
65                  70                  75                  80  


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
                85                  90                  95      


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            100                 105                 110         


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        115                 120                 125             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    130                 135                 140                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
145                 150                 155                 160 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                165                 170                 175     


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
            180                 185                 190         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        195                 200                 205             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    210                 215                 220                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230                 235 


<210>  727
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 Fc

<400>  727

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  728
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG4 Fc S228P

<400>  728

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly Lys 
225                 


<210>  729
<211>  231
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc K chain

<400>  729

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Lys Lys Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Lys Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  730
<211>  231
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc D chain

<400>  730

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Asp Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Asp Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Asp Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly 
225                 230     


<210>  731
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  Green Fluorescent protein

<400>  731

Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
1               5                   10                  15      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            20                  25                  30          


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        35                  40                  45              


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Phe Ser 
    50                  55                  60                  


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
65                  70                  75                  80  


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                85                  90                  95      


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            100                 105                 110         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        115                 120                 125             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    130                 135                 140                 


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
145                 150                 155                 160 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
                165                 170                 175     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            180                 185                 190         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
        195                 200                 205             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    210                 215                 220                 


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235         


<210>  732
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  eGFP

<400>  732

Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu Val Glu 
1               5                   10                  15      


Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly Glu Gly 
            20                  25                  30          


Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile Cys Thr 
        35                  40                  45              


Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr Leu Thr 
    50                  55                  60                  


Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys Gln His 
65                  70                  75                  80  


Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu Arg Thr 
                85                  90                  95      


Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu Val Lys 
            100                 105                 110         


Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly Ile Asp 
        115                 120                 125             


Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr Asn Tyr 
    130                 135                 140                 


Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn Gly Ile 
145                 150                 155                 160 


Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser Val Gln 
                165                 170                 175     


Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly Pro Val 
            180                 185                 190         


Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu Ser Lys 
        195                 200                 205             


Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe Val Thr 
    210                 215                 220                 


Ala Ala Gly Ile Thr His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235         


<210>  733
<211>  239
<212>  PRT
<213>  artificial sequence

<220>
<223>  eGFP

<400>  733

Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
1               5                   10                  15      


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            20                  25                  30          


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        35                  40                  45              


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    50                  55                  60                  


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
65                  70                  75                  80  


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                85                  90                  95      


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            100                 105                 110         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        115                 120                 125             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    130                 135                 140                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
145                 150                 155                 160 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                165                 170                 175     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            180                 185                 190         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        195                 200                 205             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    210                 215                 220                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235                 


<210>  734
<211>  45
<212>  PRT
<213>  artificial sequence

<220>
<223>  Moiety: COMP

<400>  734

Asp Leu Gly Pro Gln Met Leu Arg Glu Leu Gln Glu Thr Asn Ala Ala 
1               5                   10                  15      


Leu Gln Asp Val Arg Glu Leu Leu Arg Gln Gln Val Arg Glu Ile Thr 
            20                  25                  30          


Phe Leu Lys Asn Thr Val Met Glu Cys Asp Ala Cys Gly 
        35                  40                  45  


<210>  735
<211>  33
<212>  PRT
<213>  artificial sequence

<220>
<223>  Moiety: VASP

<400>  735

Asp Leu Gln Arg Val Lys Gln Glu Leu Leu Glu Glu Val Lys Lys Glu 
1               5                   10                  15      


Leu Gln Lys Val Lys Glu Glu Ile Ile Glu Ala Phe Val Gln Glu Leu 
            20                  25                  30          


Arg 
    


<210>  736
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  Moiety: ZZ12.6

<400>  736

Asp Val Gln Ala Ile Ser Ser Thr Ile Gln Asp Leu Gln Asp Gln Val 
1               5                   10                  15      


Asp Ser Leu Ala Glu Val Val Leu Gln Asn Arg Arg Gly Leu Asp Leu 
            20                  25                  30          


Leu Thr Arg Ser Gly Gly Gly Ser 
        35                  40  


<210>  737
<211>  18
<212>  PRT
<213>  artificial sequence

<220>
<223>  HSA signal peptide

<400>  737

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  738
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  Ig kappa light chain

<400>  738

Met Asp Met Arg Ala Pro Ala Gly Ile Phe Gly Phe Leu Leu Val Leu 
1               5                   10                  15      


Phe Pro Gly Tyr Arg Ser 
            20          


<210>  739
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  human azurocidin preprotein signal sequence

<400>  739

Met Thr Arg Leu Thr Val Leu Ala Leu Leu Ala Gly Leu Leu Ala Ser 
1               5                   10                  15      


Ser Arg Ala 
            


<210>  740
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  740

Met Glu Leu Gly Leu Ser Trp Ile Phe Leu Leu Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  741
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  741

Met Glu Leu Gly Leu Arg Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  742
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  742

Met Lys His Leu Trp Phe Phe Leu Leu Leu Val Ala Ala Pro Arg Trp 
1               5                   10                  15      


Val Leu Ser 
            


<210>  743
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  743

Met Asp Trp Thr Trp Arg Ile Leu Phe Leu Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210>  744
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  744

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly 
1               5                   10                  15      


Val Gln Ser 
            


<210>  745
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  745

Met Glu Phe Gly Leu Ser Trp Leu Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  746
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  746

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Leu Phe Arg Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  747
<211>  26
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG heavy chain signal peptide

<400>  747

Met Asp Leu Leu His Lys Asn Met Lys His Leu Trp Phe Phe Leu Leu 
1               5                   10                  15      


Leu Val Ala Ala Pro Arg Trp Val Leu Ser 
            20                  25      


<210>  748
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG Kappa light chain signal sequence

<400>  748

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Ser Gly Ala Arg Cys 
            20          


<210>  749
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  IgG Kappa light chain signal sequence

<400>  749

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  750
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  Gaussia luciferase

<400>  750

Met Gly Val Lys Val Leu Phe Ala Leu Ile Cys Ile Ala Val Ala Glu 
1               5                   10                  15      


Ala 
    


<210>  751
<211>  18
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human albumin

<400>  751

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  752
<211>  18
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human chymotrypsinogen

<400>  752

Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  753
<211>  14
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human interleukin-2

<400>  753

Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu Val 
1               5                   10                  


<210>  754
<211>  15
<212>  PRT
<213>  homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Human trypsinogen-2

<400>  754

Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  755
<211>  227
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc

<400>  755

Asp Lys Pro His Thr Cys Pro Leu Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  756
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc

<400>  756

Asp Pro Lys Ser Cys Asp Lys Pro His Thr Cys Pro Leu Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Ala Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  757
<211>  227
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc variant

<400>  757

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
1               5                   10                  15      


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ser Ser Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  758
<211>  232
<212>  PRT
<213>  artificial sequence

<220>
<223>  Fc variant

<400>  758

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  759
<211>  427
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  759

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
385                 390                 395                 400 


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  760
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  760

Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  761
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  761

Ser Leu Ser Cys Arg Lys Glu Glu Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  762
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  762

Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  763
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  763

Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  764
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  764

Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  765
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  765

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  766
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  766

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  767
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  767

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  768
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  768

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  769
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  769

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  770
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  770

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  771
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  771

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  772
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  772

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Asp Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  773
<211>  460
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  773

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys 
    370                 375                 380                 


Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys 
385                 390                 395                 400 


Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys 
                405                 410                 415     


Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu 
            420                 425                 430         


Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys 
        435                 440                 445             


Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455                 460 


<210>  774
<211>  460
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  774

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
                85                  90                  95      


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
            100                 105                 110         


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        115                 120                 125             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    130                 135                 140                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
145                 150                 155                 160 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                165                 170                 175     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    210                 215                 220                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
225                 230                 235                 240 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                245                 250                 255     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            260                 265                 270         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        275                 280                 285             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    290                 295                 300                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
305                 310                 315                 320 


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Ala Met 
                325                 330                 335     


His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala 
            340                 345                 350         


Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr Glu Val Arg 
        355                 360                 365             


Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala 
    370                 375                 380                 


Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile 
385                 390                 395                 400 


Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly 
                405                 410                 415     


Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met 
            420                 425                 430         


Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr Gln Ile Tyr 
        435                 440                 445             


Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln 
    450                 455                 460 


<210>  775
<211>  238
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  775

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ala 
    130                 135                 140                 


Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr 
145                 150                 155                 160 


Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys 
                165                 170                 175     


Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe 
            180                 185                 190         


Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly 
        195                 200                 205             


Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
    210                 215                 220                 


Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235             


<210>  776
<211>  238
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  776

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                85                  90                  95      


Ser Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser 
            100                 105                 110         


Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr 
        115                 120                 125             


Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr 
    130                 135                 140                 


Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu 
145                 150                 155                 160 


Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu 
                165                 170                 175     


Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys 
            180                 185                 190         


Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly 
        195                 200                 205             


Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln 
    210                 215                 220                 


Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235             


<210>  777
<211>  238
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  777

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Glu 
        115                 120                 125             


Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Val Ala 
    130                 135                 140                 


Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr 
145                 150                 155                 160 


Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys 
                165                 170                 175     


Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe 
            180                 185                 190         


Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly 
        195                 200                 205             


Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
    210                 215                 220                 


Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235             


<210>  778
<211>  238
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  778

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Glu Ala Ala Ala 
                85                  90                  95      


Lys Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser 
            100                 105                 110         


Arg Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr 
        115                 120                 125             


Thr Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr 
    130                 135                 140                 


Glu Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu 
145                 150                 155                 160 


Asp Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu 
                165                 170                 175     


Thr Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys 
            180                 185                 190         


Val Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly 
        195                 200                 205             


Thr Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln 
    210                 215                 220                 


Asp Tyr Lys Asp Asp Asp Asp Lys His His His His His His 
225                 230                 235             


<210>  779
<211>  233
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  779

Val Ala Met Arg Ser Cys Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu 
1               5                   10                  15      


Gly Thr Cys Met Ser Cys Lys Thr Ile Cys Asn His Gln Ser Gln Arg 
            20                  25                  30          


Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly 
        35                  40                  45              


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
    50                  55                  60                  


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
65                  70                  75                  80  


Arg Ser Glu Ala Ala Ala Lys Glu Ala Ala Ala Lys Lys Ala Met His 
                85                  90                  95      


Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg Gly Ile Ala Ser 
            100                 105                 110         


Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Tyr Thr Glu Val Arg Val 
        115                 120                 125             


Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu Val Cys Ala Ala 
    130                 135                 140                 


Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp Asp Ser Ile Cys 
145                 150                 155                 160 


Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr Ile Gln Gly Leu 
                165                 170                 175     


Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val Glu Leu Met Tyr 
            180                 185                 190         


Pro Pro Pro Tyr Tyr Glu Gly Ile Gly Asn Gly Thr Gln Ile Tyr Val 
        195                 200                 205             


Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Asp Tyr Lys Asp Asp 
    210                 215                 220                 


Asp Asp Lys His His His His His His 
225                 230             


<210>  780
<211>  460
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  780

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gln Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys 
    130                 135                 140                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro 
145                 150                 155                 160 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                165                 170                 175     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            180                 185                 190         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        195                 200                 205             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    210                 215                 220                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
225                 230                 235                 240 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                245                 250                 255     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            260                 265                 270         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        275                 280                 285             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    290                 295                 300                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
305                 310                 315                 320 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                325                 330                 335     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            340                 345                 350         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys 
    370                 375                 380                 


Pro Glu Glu Gln Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys 
385                 390                 395                 400 


Lys Thr Ile Cys Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys 
                405                 410                 415     


Arg Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu 
            420                 425                 430         


Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys 
        435                 440                 445             


Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455                 460 


<210>  781
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  781

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Trp Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Ser Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Arg Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Leu Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys Pro Glu Glu Gln 
    370                 375                 380                 


Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys 
385                 390                 395                 400 


Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser 
                405                 410                 415     


Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys 
            420                 425                 430         


Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr 
        435                 440                 445             


Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455     


<210>  782
<211>  456
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  782

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Ser Tyr Met Met Gly Asn Glu Leu Thr Phe Pro Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Gln Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Val Ala Met Arg Ser Cys Pro Glu Glu Gln 
    370                 375                 380                 


Tyr Trp Asp Pro Leu Leu Gly Thr Cys Met Ser Cys Lys Thr Ile Cys 
385                 390                 395                 400 


Asn His Gln Ser Gln Arg Thr Cys Ala Ala Phe Cys Arg Ser Leu Ser 
                405                 410                 415     


Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys 
            420                 425                 430         


Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr 
        435                 440                 445             


Phe Cys Glu Asn Lys Leu Arg Ser 
    450                 455     


<210>  783
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  783

Ser Leu Ser Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  784
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  784

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Tyr Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  785
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant TACI

<400>  785

Ser Leu Ser Cys Arg Lys Glu Gln Gly Glu Phe Tyr Asp His Leu Leu 
1               5                   10                  15      


Arg Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
            20                  25                  30          


Cys Ala Asp Phe Cys Glu Asn Lys Leu Arg Ser 
        35                  40              


<210>  786
<211>  418
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  786

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
    130                 135                 140                 


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        195                 200                 205             


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser Cys Arg Lys Glu Gln Gly 
    370                 375                 380                 


Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser Cys Ala Ser Ile 
385                 390                 395                 400 


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
                405                 410                 415     


Arg Ser 
        


<210>  787
<211>  424
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  787

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            260                 265                 270         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser 
    370                 375                 380                 


Cys Arg Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys 
385                 390                 395                 400 


Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr 
                405                 410                 415     


Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 


<210>  788
<211>  427
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  788

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys 
    130                 135                 140                 


Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 
145                 150                 155                 160 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                165                 170                 175     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            180                 185                 190         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        195                 200                 205             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    210                 215                 220                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
225                 230                 235                 240 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                245                 250                 255     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            260                 265                 270         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        275                 280                 285             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    290                 295                 300                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
305                 310                 315                 320 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                325                 330                 335     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            340                 345                 350         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Ser Leu Ser Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu 
385                 390                 395                 400 


Gln Asp Cys Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln 
                405                 410                 415     


Cys Ala Tyr Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 425         


<210>  789
<211>  418
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  789

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val 
    130                 135                 140                 


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
145                 150                 155                 160 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                165                 170                 175     


His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
            180                 185                 190         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
        195                 200                 205             


Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn 
    210                 215                 220                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro 
225                 230                 235                 240 


Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln 
                245                 250                 255     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            260                 265                 270         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val 
        275                 280                 285             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    290                 295                 300                 


Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
305                 310                 315                 320 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                325                 330                 335     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            340                 345                 350         


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        355                 360                 365             


Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser Cys Arg Lys Glu Glu Gly 
    370                 375                 380                 


Lys Phe Tyr Asp His Leu Leu Gln Asp Cys Ile Ser Cys Ala Ser Ile 
385                 390                 395                 400 


Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys Glu Asn Lys Leu 
                405                 410                 415     


Arg Ser 
        


<210>  790
<211>  424
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  790

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys 
    130                 135                 140                 


Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
145                 150                 155                 160 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
                165                 170                 175     


Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp 
            180                 185                 190         


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
        195                 200                 205             


Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
    210                 215                 220                 


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
225                 230                 235                 240 


Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
                245                 250                 255     


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu 
            260                 265                 270         


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
        275                 280                 285             


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
    290                 295                 300                 


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
305                 310                 315                 320 


Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn 
                325                 330                 335     


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
            340                 345                 350         


Gln Lys Ser Leu Ser Leu Ser Leu Gly Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser 
    370                 375                 380                 


Cys Arg Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu Gln Asp Cys 
385                 390                 395                 400 


Ile Ser Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr 
                405                 410                 415     


Phe Cys Glu Asn Lys Leu Arg Ser 
            420                 


<210>  791
<211>  422
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  791

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    130                 135                 140                 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            180                 185                 190         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        195                 200                 205             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    210                 215                 220                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                245                 250                 255     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            260                 265                 270         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        275                 280                 285             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    290                 295                 300                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                325                 330                 335     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            340                 345                 350         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser Cys Arg 
    370                 375                 380                 


Lys Glu Gln Gly Lys Phe Tyr Asp His Leu Leu Arg Asp Cys Ile Ser 
385                 390                 395                 400 


Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys 
                405                 410                 415     


Glu Asn Lys Leu Arg Ser 
            420         


<210>  792
<211>  422
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  792

Lys Ala Met His Val Ala Gln Pro Ala Val Val Leu Ala Ser Ser Arg 
1               5                   10                  15      


Gly Ile Ala Ser Phe Val Cys Glu Tyr Ala Ser Pro Gly Lys Ala Thr 
            20                  25                  30          


Glu Val Arg Val Thr Val Leu Arg Gln Ala Asp Ser Gln Val Thr Glu 
        35                  40                  45              


Val Cys Ala Ala Thr Tyr Met Met Gly Asn Glu Leu Thr Phe Leu Asp 
    50                  55                  60                  


Asp Ser Ile Cys Thr Gly Thr Ser Ser Gly Asn Gln Val Asn Leu Thr 
65                  70                  75                  80  


Ile Gln Gly Leu Arg Ala Met Asp Thr Gly Leu Tyr Ile Cys Lys Val 
                85                  90                  95      


Glu Leu Met Tyr Pro Pro Pro Tyr Tyr Leu Gly Ile Gly Asn Gly Thr 
            100                 105                 110         


Gln Ile Tyr Val Ile Asp Pro Glu Pro Cys Pro Asp Ser Asp Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    130                 135                 140                 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            180                 185                 190         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        195                 200                 205             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    210                 215                 220                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                245                 250                 255     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            260                 265                 270         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        275                 280                 285             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    290                 295                 300                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                325                 330                 335     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            340                 345                 350         


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Leu Ser Cys Arg 
    370                 375                 380                 


Lys Glu Glu Gly Lys Phe Tyr Asp His Leu Leu Gln Asp Cys Ile Ser 
385                 390                 395                 400 


Cys Ala Ser Ile Cys Gly Gln His Pro Lys Gln Cys Ala Tyr Phe Cys 
                405                 410                 415     


Glu Asn Lys Leu Arg Ser 
            420         


<210>  793
<211>  1281
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  793
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcca gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccatggaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gcagatgtac      300

ccgccacctt acctcctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agcccaaaag ctccgacaag      420

actcacacat gccccccttg tccagcgcct gaagctgagg gtgcgccctc tgtcttcctt      480

ttccccccta agccgaaaga taccctgatg atctcccgca ctcccgaagt cacatgtgtt      540

gttgtcgacg tatctcatga agatcctgag gtgaaattca actggtatgt agacggggtc      600

gaagttcata atgctaagac taagccacga gaagagcaat acaactcaac gtatcgggtg      660

gtgagcgttc tgacggttct gcaccaagat tggcttaatg gaaaagagta taagtgcaag      720

gtgtccaaca aggctcttcc ggcacccatc gaaaagacga tttccaaagc gaaaggccaa      780

cctagggaac cgcaagttta cactttgccc ccgtcaagag acgaacttac caagaatcaa      840

gtttccctga cgtgccttgt gaagggcttc taccctagcg atatagcagt tgagtgggaa      900

tctaacggcc agcccgaaaa taattataag actactccgc ccgtgctgga cagtgatggt      960

tcatttttcc tgtattcaaa actcactgtg gacaaatcta gatggcagca gggtaatgtg     1020

ttctcttgtt cagttatgca cgaggcattg cacaatcact atacgcaaaa aagtttgtct     1080

ctctctccgg gggggggtgg cggatcagga ggtggcggtt caggcggagg aggttctggg     1140

ggtgggggtt ctagtctctc ttgcaggaaa gagcaaggcg aatattacga ccatcttttg     1200

cgagactgta taagctgtgc gtctatttgt ggacaacacc ctaaacaatg tgctgatttc     1260

tgtgaaaata agcttcgatc t                                               1281


<210>  794
<211>  1281
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  794
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcca gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccatggaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gcagatgtac      300

ccgccacctt acctcctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agcccaaaag ctccgacaag      420

actcacacat gccccccttg tccagcgcct gaagctgagg gtgcgccctc tgtcttcctt      480

ttccccccta agccgaaaga taccctgatg atctcccgca ctcccgaagt cacatgtgtt      540

gttgtcgacg tatctcatga agatcctgag gtgaaattca actggtatgt agacggggtc      600

gaagttcata atgctaagac taagccacga gaagagcaat acaactcaac gtatcgggtg      660

gtgagcgttc tgacggttct gcaccaagat tggcttaatg gaaaagagta taagtgcaag      720

gtgtccaaca aggctcttcc ggcacccatc gaaaagacga tttccaaagc gaaaggccaa      780

cctagggaac cgcaagttta cactttgccc ccgtcaagag acgaacttac caagaatcaa      840

gtttccctga cgtgccttgt gaagggcttc taccctagcg atatagcagt tgagtgggaa      900

tctaacggcc agcccgaaaa taattataag actactccgc ccgtgctgga cagtgatggt      960

tcatttttcc tgtattcaaa actcactgtg gacaaatcta gatggcagca gggtaatgtg     1020

ttctcttgtt cagttatgca cgaggcattg cacaatcact atacgcaaaa aagtttgtct     1080

ctctctccgg gggggggtgg cggatcagga ggtggcggtt caggcggagg aggttctggg     1140

ggtgggggtt ctagtctctc ttgcaggaaa gaggaaggca aattttacga ccatcttttg     1200

caagactgta taagctgtgc gtctatttgt ggacaacacc ctaaacaatg tgcttatttc     1260

tgtgaaaata agcttcgatc t                                               1281


<210>  795
<211>  1281
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  795
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agcccaaaag ctccgacaag      420

actcacacat gccccccttg tccagcgcct gaagctgagg gtgcgccctc tgtcttcctt      480

ttccccccta agccgaaaga taccctgatg atctcccgca ctcccgaagt cacatgtgtt      540

gttgtcgacg tatctcatga agatcctgag gtgaaattca actggtatgt agacggggtc      600

gaagttcata atgctaagac taagccacga gaagagcaat acaactcaac gtatcgggtg      660

gtgagcgttc tgacggttct gcaccaagat tggcttaatg gaaaagagta taagtgcaag      720

gtgtccaaca aggctcttcc ggcacccatc gaaaagacga tttccaaagc gaaaggccaa      780

cctagggaac cgcaagttta cactttgccc ccgtcaagag acgaacttac caagaatcaa      840

gtttccctga cgtgccttgt gaagggcttc taccctagcg atatagcagt tgagtgggaa      900

tctaacggcc agcccgaaaa taattataag actactccgc ccgtgctgga cagtgatggt      960

tcatttttcc tgtattcaaa actcactgtg gacaaatcta gatggcagca gggtaatgtg     1020

ttctcttgtt cagttatgca cgaggcattg cacaatcact atacgcaaaa aagtttgtct     1080

ctctctccgg gggggggtgg cggatcagga ggtggcggtt caggcggagg aggttctggg     1140

ggtgggggtt ctagtctctc ttgcaggaaa gagcaaggcg aatattacga ccatcttttg     1200

cgagactgta taagctgtgc gtctatttgt ggacaacacc ctaaacaatg tgctgatttc     1260

tgtgaaaata agcttcgatc t                                               1281


<210>  796
<211>  1281
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  796
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agcccaaaag ctccgacaag      420

actcacacat gccccccttg tccagcgcct gaagctgagg gtgcgccctc tgtcttcctt      480

ttccccccta agccgaaaga taccctgatg atctcccgca ctcccgaagt cacatgtgtt      540

gttgtcgacg tatctcatga agatcctgag gtgaaattca actggtatgt agacggggtc      600

gaagttcata atgctaagac taagccacga gaagagcaat acaactcaac gtatcgggtg      660

gtgagcgttc tgacggttct gcaccaagat tggcttaatg gaaaagagta taagtgcaag      720

gtgtccaaca aggctcttcc ggcacccatc gaaaagacga tttccaaagc gaaaggccaa      780

cctagggaac cgcaagttta cactttgccc ccgtcaagag acgaacttac caagaatcaa      840

gtttccctga cgtgccttgt gaagggcttc taccctagcg atatagcagt tgagtgggaa      900

tctaacggcc agcccgaaaa taattataag actactccgc ccgtgctgga cagtgatggt      960

tcatttttcc tgtattcaaa actcactgtg gacaaatcta gatggcagca gggtaatgtg     1020

ttctcttgtt cagttatgca cgaggcattg cacaatcact atacgcaaaa aagtttgtct     1080

ctctctccgg gggggggtgg cggatcagga ggtggcggtt caggcggagg aggttctggg     1140

ggtgggggtt ctagtctctc ttgcaggaaa gagcaaggca aattttacga ccatcttttg     1200

cgagactgta taagctgtgc gtctatttgt ggacaacacc ctaaacaatg tgcttatttc     1260

tgtgaaaata agcttcgatc t                                               1281


<210>  797
<211>  1254
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  797
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag tggaatgccc tccttgtcct      420

gctcctccag tggctggccc ttccgtgttt ctgttccctc caaagcctaa ggacaccctg      480

atgatcagca gaacccctga agtgacctgc gtggtggtgg atgtgtctca cgaagatccc      540

gaggtgcagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagcct      600

agagaggaac agttcaacag caccttcaga gtggtgtccg tgctgaccgt ggtgcatcag      660

gattggctga acggcaaaga gtacaagtgc aaggtgtcca acaagggcct gcctgctcct      720

atcgagaaaa ccatctctaa gaccaagggg cagccccgcg aacctcaggt ttacacactg      780

cctccaagcc gggaagagat gaccaagaac caggtgtccc tgacctgcct cgtgaagggc      840

ttttacccca gcgacattag cgtggaatgg gagagcaatg gccagcctga gaacaactac      900

aagaccacac ctcctatgct ggacagcgac ggctcattct tcctgtacag caagctgaca      960

gtggacaagt ccagatggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1020

ctgcacaacc actacaccca gaagtccctg agcctgtctc ctggcggggg tggcggatca     1080

ggaggtggcg gttcaggcgg aggaggttct gggggtgggg gttctagtct ctcttgcagg     1140

aaagagcaag gcaaatttta cgaccatctt ttgcgagact gtataagctg tgcgtctatt     1200

tgtggacaac accctaaaca atgtgcttat ttctgtgaaa ataagcttcg atct           1254


<210>  798
<211>  1272
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  798
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agtccaaata tggtccccca      420

tgcccaccat gcccagcacc tgagttcctg gggggaccat cagtcttcct gttcccccca      480

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      540

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      600

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      660

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      720

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag      780

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg      840

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg      900

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      960

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1020

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1080

ggtgggggtg gcggatcagg aggtggcggt tcaggcggag gaggttctgg gggtgggggt     1140

tctagtctct cttgcaggaa agagcaaggc aaattttacg accatctttt gcgagactgt     1200

ataagctgtg cgtctatttg tggacaacac cctaaacaat gtgcttattt ctgtgaaaat     1260

aagcttcgat ct                                                         1272


<210>  799
<211>  1281
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  799
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agcccaaaag ctccgacaag      420

actcacacat gccccccttg tccagcgcct gaagctgagg gtgcgccctc tgtcttcctt      480

ttccccccta agccgaaaga taccctgatg atctcccgca ctcccgaagt cacatgtgtt      540

gttgtcgacg tatctcatga agatcctgag gtgaaattca actggtatgt agacggggtc      600

gaagttcata atgctaagac taagccacga gaagagcaat acaactcaac gtatcgggtg      660

gtgagcgttc tgacggttct gcaccaagat tggcttaatg gaaaagagta taagtgcaag      720

gtgtccaaca aggctcttcc ggcacccatc gaaaagacga tttccaaagc gaaaggccaa      780

cctagggaac cgcaagttta cactttgccc ccgtcaagag acgaacttac caagaatcaa      840

gtttccctga cgtgccttgt gaagggcttc taccctagcg atatagcagt tgagtgggaa      900

tctaacggcc agcccgaaaa taattataag actactccgc ccgtgctgga cagtgatggt      960

tcatttttcc tgtattcaaa actcactgtg gacaaatcta gatggcagca gggtaatgtg     1020

ttctcttgtt cagttatgca cgaggcattg cacaatcact atacgcaaaa aagtttgtct     1080

ctctctccgg gggggggtgg cggatcagga ggtggcggtt caggcggagg aggttctggg     1140

ggtgggggtt ctagtctctc ttgcaggaaa gaggaaggca aattttacga ccatcttttg     1200

caagactgta taagctgtgc gtctatttgt ggacaacacc ctaaacaatg tgcttatttc     1260

tgtgaaaata agcttcgatc t                                               1281


<210>  800
<211>  1254
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  800
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag tggaatgccc tccttgtcct      420

gctcctccag tggctggccc ttccgtgttt ctgttccctc caaagcctaa ggacaccctg      480

atgatcagca gaacccctga agtgacctgc gtggtggtgg atgtgtctca cgaagatccc      540

gaggtgcagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagcct      600

agagaggaac agttcaacag caccttcaga gtggtgtccg tgctgaccgt ggtgcatcag      660

gattggctga acggcaaaga gtacaagtgc aaggtgtcca acaagggcct gcctgctcct      720

atcgagaaaa ccatctctaa gaccaagggg cagccccgcg aacctcaggt ttacacactg      780

cctccaagcc gggaagagat gaccaagaac caggtgtccc tgacctgcct cgtgaagggc      840

ttttacccca gcgacattag cgtggaatgg gagagcaatg gccagcctga gaacaactac      900

aagaccacac ctcctatgct ggacagcgac ggctcattct tcctgtacag caagctgaca      960

gtggacaagt ccagatggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc     1020

ctgcacaacc actacaccca gaagtccctg agcctgtctc ctggcggggg tggcggatca     1080

ggaggtggcg gttcaggcgg aggaggttct gggggtgggg gttctagtct ctcttgcagg     1140

aaagaggaag gcaaatttta cgaccatctt ttgcaagact gtataagctg tgcgtctatt     1200

tgtggacaac accctaaaca atgtgcttat ttctgtgaaa ataagcttcg atct           1254


<210>  801
<211>  1272
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  801
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag agtccaaata tggtccccca      420

tgcccaccat gcccagcacc tgagttcctg gggggaccat cagtcttcct gttcccccca      480

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      540

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      600

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      660

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac      720

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag      780

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg      840

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg      900

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc      960

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1020

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1080

ggtgggggtg gcggatcagg aggtggcggt tcaggcggag gaggttctgg gggtgggggt     1140

tctagtctct cttgcaggaa agaggaaggc aaattttacg accatctttt gcaagactgt     1200

ataagctgtg cgtctatttg tggacaacac cctaaacaat gtgcttattt ctgtgaaaat     1260

aagcttcgat ct                                                         1272


<210>  802
<211>  1266
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  802
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag acaagactca cacatgcccc      420

ccttgtccag cgcctgaagc tgagggtgcg ccctctgtct tccttttccc ccctaagccg      480

aaagataccc tgatgatctc ccgcactccc gaagtcacat gtgttgttgt cgacgtatct      540

catgaagatc ctgaggtgaa attcaactgg tatgtagacg gggtcgaagt tcataatgct      600

aagactaagc cacgagaaga gcaatacaac tcaacgtatc gggtggtgag cgttctgacg      660

gttctgcacc aagattggct taatggaaaa gagtataagt gcaaggtgtc caacaaggct      720

cttccggcac ccatcgaaaa gacgatttcc aaagcgaaag gccaacctag ggaaccgcaa      780

gtttacactt tgcccccgtc aagagacgaa cttaccaaga atcaagtttc cctgacgtgc      840

cttgtgaagg gcttctaccc tagcgatata gcagttgagt gggaatctaa cggccagccc      900

gaaaataatt ataagactac tccgcccgtg ctggacagtg atggttcatt tttcctgtat      960

tcaaaactca ctgtggacaa atctagatgg cagcagggta atgtgttctc ttgttcagtt     1020

atgcacgagg cattgcacaa tcactatacg caaaaaagtt tgtctctctc tccggggggg     1080

ggtggcggat caggaggtgg cggttcaggc ggaggaggtt ctgggggtgg gggttctagt     1140

ctctcttgca ggaaagagca aggcaaattt tacgaccatc ttttgcgaga ctgtataagc     1200

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt     1260

cgatct                                                                1266


<210>  803
<211>  1266
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant multi domain immunomodulatory molecule

<400>  803
aaagcgatgc acgtcgccca gcctgctgtc gtactcgcta gctcacgcgg catcgcaagt       60

ttcgtatgcg aatatgcctc tccaggaaaa gcgaccgagg tcagagttac tgtactgaga      120

caagctgatt cacaagtgac tgaggtctgc gctgctactt atatgatggg gaacgagctg      180

actttccttg atgactcaat ctgtaccggc accagcagtg ggaaccaagt aaatcttact      240

attcaaggac tgagggcaat ggacacggga ctttacattt gtaaggtcga gctgatgtac      300

ccgccacctt actacctcgg aatcggtaat ggtacgcaaa tttatgttat agatcctgaa      360

ccgtgccccg attccgacgg atccggtgga ggagggtcag acaagactca cacatgcccc      420

ccttgtccag cgcctgaagc tgagggtgcg ccctctgtct tccttttccc ccctaagccg      480

aaagataccc tgatgatctc ccgcactccc gaagtcacat gtgttgttgt cgacgtatct      540

catgaagatc ctgaggtgaa attcaactgg tatgtagacg gggtcgaagt tcataatgct      600

aagactaagc cacgagaaga gcaatacaac tcaacgtatc gggtggtgag cgttctgacg      660

gttctgcacc aagattggct taatggaaaa gagtataagt gcaaggtgtc caacaaggct      720

cttccggcac ccatcgaaaa gacgatttcc aaagcgaaag gccaacctag ggaaccgcaa      780

gtttacactt tgcccccgtc aagagacgaa cttaccaaga atcaagtttc cctgacgtgc      840

cttgtgaagg gcttctaccc tagcgatata gcagttgagt gggaatctaa cggccagccc      900

gaaaataatt ataagactac tccgcccgtg ctggacagtg atggttcatt tttcctgtat      960

tcaaaactca ctgtggacaa atctagatgg cagcagggta atgtgttctc ttgttcagtt     1020

atgcacgagg cattgcacaa tcactatacg caaaaaagtt tgtctctctc tccggggggg     1080

ggtggcggat caggaggtgg cggttcaggc ggaggaggtt ctgggggtgg gggttctagt     1140

ctctcttgca ggaaagagga aggcaaattt tacgaccatc ttttgcaaga ctgtataagc     1200

tgtgcgtcta tttgtggaca acaccctaaa caatgtgctt atttctgtga aaataagctt     1260

cgatct                                                                1266


<210>  804
<211>  227
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant Fc

<400>  804

Asp Lys Pro His Thr Cys Pro Leu Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Ala Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  805
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  805

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  806
<211>  65
<212>  PRT
<213>  artificial sequence

<220>
<223>  linker

<400>  806

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser 
65  


<210>  807
<211>  587
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  807

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        355                 360                 365             


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
    370                 375                 380                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
385                 390                 395                 400 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                405                 410                 415     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            420                 425                 430         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        435                 440                 445             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    450                 455                 460                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
465                 470                 475                 480 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                485                 490                 495     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            500                 505                 510         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        515                 520                 525             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    530                 535                 540                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
545                 550                 555                 560 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                565                 570                 575     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            580                 585         


<210>  808
<211>  291
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  808

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly 
    290     


<210>  809
<211>  359
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  809

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp 
305                 310                 315                 320 


Ser Leu Leu His Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn 
                325                 330                 335     


Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn 
            340                 345                 350         


Ser Val Lys Gly Thr Asn Ala 
        355                 


<210>  810
<211>  587
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  810

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
65                  70                  75                  80  


Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
                85                  90                  95      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            100                 105                 110         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        115                 120                 125             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    130                 135                 140                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
145                 150                 155                 160 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                165                 170                 175     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            180                 185                 190         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        195                 200                 205             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    210                 215                 220                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
225                 230                 235                 240 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                245                 250                 255     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            260                 265                 270         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        275                 280                 285             


Lys Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
305                 310                 315                 320 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                325                 330                 335     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            340                 345                 350         


Gly Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        355                 360                 365             


Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 
    370                 375                 380                 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
385                 390                 395                 400 


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                405                 410                 415     


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            420                 425                 430         


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        435                 440                 445             


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    450                 455                 460                 


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
465                 470                 475                 480 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                485                 490                 495     


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            500                 505                 510         


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        515                 520                 525             


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    530                 535                 540                 


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
545                 550                 555                 560 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                565                 570                 575     


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            580                 585         


<210>  811
<211>  291
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  811

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly 
    290     


<210>  812
<211>  359
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  812

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser 
    50                  55                  60                  


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu 
65                  70                  75                  80  


Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                85                  90                  95      


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            100                 105                 110         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        115                 120                 125             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    130                 135                 140                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
145                 150                 155                 160 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                165                 170                 175     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            180                 185                 190         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        195                 200                 205             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    210                 215                 220                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
225                 230                 235                 240 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                245                 250                 255     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            260                 265                 270         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        275                 280                 285             


Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    290                 295                 300                 


Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp 
305                 310                 315                 320 


Ala Leu Leu Tyr Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn 
                325                 330                 335     


Thr Pro Pro Leu Thr Cys Gln Gln Tyr Cys Asn Ala Ser Val Thr Asn 
            340                 345                 350         


Ser Val Lys Gly Thr Asn Ala 
        355                 


<210>  813
<211>  359
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  813

Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr Phe Asp Ser Leu 
1               5                   10                  15      


Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser Ser Asn Thr Pro 
            20                  25                  30          


Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val Thr Asn Ser Val 
        35                  40                  45              


Lys Gly Thr Asn Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Leu Gln Met Ala Gly Gln Cys Ser Gln Asn Glu Tyr 
65                  70                  75                  80  


Phe Asp Ser Leu Leu Leu Ala Cys Ile Pro Cys Gln Leu Arg Cys Ser 
                85                  90                  95      


Ser Asn Thr Pro Pro Leu Thr Cys Gln Arg Tyr Cys Asn Ala Ser Val 
            100                 105                 110         


Thr Asn Ser Val Lys Gly Thr Asn Ala Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    130                 135                 140                 


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            180                 185                 190         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        195                 200                 205             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    210                 215                 220                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                245                 250                 255     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            260                 265                 270         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        275                 280                 285             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    290                 295                 300                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                325                 330                 335     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            340                 345                 350         


Ser Leu Ser Leu Ser Pro Gly 
        355                 


<210>  814
<211>  1761
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  814
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gcacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcgg gatccggtgg tggcgggtca      180

gggggaggtg gaagcgagcc caagtcctca gataagactc atacttgccc cccctgtccc      240

gcccctgagg ccgaaggcgc accgtcagtg tttttgttcc caccaaagcc taaggacaca      300

ctgatgataa gcagaacacc tgaggtaacc tgtgttgttg tggatgtaag ccacgaagat      360

ccggaggtta agtttaactg gtacgtggac ggtgtagaag tccataatgc taagacgaag      420

ccgagggagg aacaatacaa ctccacgtat agagtggtct ccgtcttgac cgtactccat      480

caagactggc tcaacgggaa agagtacaag tgtaaagtct ctaacaaagc tcttcctgca      540

ccgattgaga aaaccatatc taaagccaag ggacaaccga gagaaccaca ggtttacacg      600

ctccccccca gtagagacga acttacaaaa aaccaggtca gtcttacctg cctcgtcaaa      660

ggcttctacc cctctgacat cgctgttgag tgggaatcta acggccaacc tgagaacaat      720

tacaaaacaa ccccgcctgt ccttgactca gacggttcct tttttcttta cagcaagctg      780

accgtcgaca aatcacggtg gcaacaaggc aatgtgtttt cctgttccgt gatgcacgag      840

gcactgcaca accactacac tcaaaaatcc ctttcccttt ccccaggggg aggtggaggg      900

agcggtggag gtggtagcgg gggtggaggc tcaggtggtg ggggttccgg cggtggcgga      960

agtggaggcg gtggctctgg tggtggcgga tctggcggag gaggcagcgg cggaggtggg     1020

tctgggggtg gaggctccgg aggcggggga agcggtggag gagggtcaga gcccaaaagc     1080

tccgacaaga ctcacacatg ccccccttgt ccagcgcctg aagctgaggg tgcgccctct     1140

gtcttccttt tcccccctaa gccgaaagat accctgatga tctcccgcac tcccgaagtc     1200

acatgtgttg ttgtcgacgt atctcatgaa gatcctgagg tgaaattcaa ctggtatgta     1260

gacggggtcg aagttcataa tgctaagact aagccacgag aagagcaata caactcaacg     1320

tatcgggtgg tgagcgttct gacggttctg caccaagatt ggcttaatgg aaaagagtat     1380

aagtgcaagg tgtccaacaa ggctcttccg gcacccatcg aaaagacgat ttccaaagcg     1440

aaaggccaac ctagggaacc gcaagtttac actttgcccc cgtcaagaga cgaacttacc     1500

aagaatcaag tttccctgac gtgccttgtg aagggcttct accctagcga tatagcagtt     1560

gagtgggaat ctaacggcca gcccgaaaat aattataaga ctactccgcc cgtgctggac     1620

agtgatggtt catttttcct gtattcaaaa ctcactgtgg acaaatctag atggcagcag     1680

ggtaatgtgt tctcttgttc agttatgcac gaggcattgc acaatcacta tacgcaaaaa     1740

agtttgtctc tctctccggg g                                               1761


<210>  815
<211>  873
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  815
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gcacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcgg gatccggtgg aggagggtca      180

gagcccaaaa gctccgacaa gactcacaca tgcccccctt gtccagcgcc tgaagctgag      240

ggtgcgccct ctgtcttcct tttcccccct aagccgaaag ataccctgat gatctcccgc      300

actcccgaag tcacatgtgt tgttgtcgac gtatctcatg aagatcctga ggtgaaattc      360

aactggtatg tagacggggt cgaagttcat aatgctaaga ctaagccacg agaagagcaa      420

tacaactcaa cgtatcgggt ggtgagcgtt ctgacggttc tgcaccaaga ttggcttaat      480

ggaaaagagt ataagtgcaa ggtgtccaac aaggctcttc cggcacccat cgaaaagacg      540

atttccaaag cgaaaggcca acctagggaa ccgcaagttt acactttgcc cccgtcaaga      600

gacgaactta ccaagaatca agtttccctg acgtgccttg tgaagggctt ctaccctagc      660

gatatagcag ttgagtggga atctaacggc cagcccgaaa ataattataa gactactccg      720

cccgtgctgg acagtgatgg ttcatttttc ctgtattcaa aactcactgt ggacaaatct      780

agatggcagc agggtaatgt gttctcttgt tcagttatgc acgaggcatt gcacaatcac      840

tatacgcaaa aaagtttgtc tctctctccg ggg                                   873


<210>  816
<211>  1077
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  816
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gcacgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcgg gatccggtgg aggagggtca      180

gagcccaaaa gctccgacaa gactcacaca tgcccccctt gtccagcgcc tgaagctgag      240

ggtgcgccct ctgtcttcct tttcccccct aagccgaaag ataccctgat gatctcccgc      300

actcccgaag tcacatgtgt tgttgtcgac gtatctcatg aagatcctga ggtgaaattc      360

aactggtatg tagacggggt cgaagttcat aatgctaaga ctaagccacg agaagagcaa      420

tacaactcaa cgtatcgggt ggtgagcgtt ctgacggttc tgcaccaaga ttggcttaat      480

ggaaaagagt ataagtgcaa ggtgtccaac aaggctcttc cggcacccat cgaaaagacg      540

atttccaaag cgaaaggcca acctagggaa ccgcaagttt acactttgcc cccgtcaaga      600

gacgaactta ccaagaatca agtttccctg acgtgccttg tgaagggctt ctaccctagc      660

gatatagcag ttgagtggga atctaacggc cagcccgaaa ataattataa gactactccg      720

cccgtgctgg acagtgatgg ttcatttttc ctgtattcaa aactcactgt ggacaaatct      780

agatggcagc agggtaatgt gttctcttgt tcagttatgc acgaggcatt gcacaatcac      840

tatacgcaaa aaagtttgtc tctctctccg gggggaggtg gtggatcagg cggtggaggt      900

tccggaggag gtggatctct gcaaatggcg ggacagtgta gtcaaaatga gtacttcgac      960

agccttcttc atgcctgtat tccgtgccaa ctgcggtgca gcagtaacac gccaccgctc     1020

acttgccaga ggtattgtaa tgccagtgta actaacagtg taaaagggac taatgct        1077


<210>  817
<211>  1761
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  817
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gctcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcgg gatccggtgg tggcgggtca      180

gggggaggtg gaagcgagcc caagtcctca gataagactc atacttgccc cccctgtccc      240

gcccctgagg ccgaaggcgc accgtcagtg tttttgttcc caccaaagcc taaggacaca      300

ctgatgataa gcagaacacc tgaggtaacc tgtgttgttg tggatgtaag ccacgaagat      360

ccggaggtta agtttaactg gtacgtggac ggtgtagaag tccataatgc taagacgaag      420

ccgagggagg aacaatacaa ctccacgtat agagtggtct ccgtcttgac cgtactccat      480

caagactggc tcaacgggaa agagtacaag tgtaaagtct ctaacaaagc tcttcctgca      540

ccgattgaga aaaccatatc taaagccaag ggacaaccga gagaaccaca ggtttacacg      600

ctccccccca gtagagacga acttacaaaa aaccaggtca gtcttacctg cctcgtcaaa      660

ggcttctacc cctctgacat cgctgttgag tgggaatcta acggccaacc tgagaacaat      720

tacaaaacaa ccccgcctgt ccttgactca gacggttcct tttttcttta cagcaagctg      780

accgtcgaca aatcacggtg gcaacaaggc aatgtgtttt cctgttccgt gatgcacgag      840

gcactgcaca accactacac tcaaaaatcc ctttcccttt ccccaggggg aggtggaggg      900

agcggtggag gtggtagcgg gggtggaggc tcaggtggtg ggggttccgg cggtggcgga      960

agtggaggcg gtggctctgg tggtggcgga tctggcggag gaggcagcgg cggaggtggg     1020

tctgggggtg gaggctccgg aggcggggga agcggtggag gagggtcaga gcccaaaagc     1080

tccgacaaga ctcacacatg ccccccttgt ccagcgcctg aagctgaggg tgcgccctct     1140

gtcttccttt tcccccctaa gccgaaagat accctgatga tctcccgcac tcccgaagtc     1200

acatgtgttg ttgtcgacgt atctcatgaa gatcctgagg tgaaattcaa ctggtatgta     1260

gacggggtcg aagttcataa tgctaagact aagccacgag aagagcaata caactcaacg     1320

tatcgggtgg tgagcgttct gacggttctg caccaagatt ggcttaatgg aaaagagtat     1380

aagtgcaagg tgtccaacaa ggctcttccg gcacccatcg aaaagacgat ttccaaagcg     1440

aaaggccaac ctagggaacc gcaagtttac actttgcccc cgtcaagaga cgaacttacc     1500

aagaatcaag tttccctgac gtgccttgtg aagggcttct accctagcga tatagcagtt     1560

gagtgggaat ctaacggcca gcccgaaaat aattataaga ctactccgcc cgtgctggac     1620

agtgatggtt catttttcct gtattcaaaa ctcactgtgg acaaatctag atggcagcag     1680

ggtaatgtgt tctcttgttc agttatgcac gaggcattgc acaatcacta tacgcaaaaa     1740

agtttgtctc tctctccggg g                                               1761


<210>  818
<211>  873
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  818
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gctcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcgg gatccggtgg aggagggtca      180

gagcccaaaa gctccgacaa gactcacaca tgcccccctt gtccagcgcc tgaagctgag      240

ggtgcgccct ctgtcttcct tttcccccct aagccgaaag ataccctgat gatctcccgc      300

actcccgaag tcacatgtgt tgttgtcgac gtatctcatg aagatcctga ggtgaaattc      360

aactggtatg tagacggggt cgaagttcat aatgctaaga ctaagccacg agaagagcaa      420

tacaactcaa cgtatcgggt ggtgagcgtt ctgacggttc tgcaccaaga ttggcttaat      480

ggaaaagagt ataagtgcaa ggtgtccaac aaggctcttc cggcacccat cgaaaagacg      540

atttccaaag cgaaaggcca acctagggaa ccgcaagttt acactttgcc cccgtcaaga      600

gacgaactta ccaagaatca agtttccctg acgtgccttg tgaagggctt ctaccctagc      660

gatatagcag ttgagtggga atctaacggc cagcccgaaa ataattataa gactactccg      720

cccgtgctgg acagtgatgg ttcatttttc ctgtattcaa aactcactgt ggacaaatct      780

agatggcagc agggtaatgt gttctcttgt tcagttatgc acgaggcatt gcacaatcac      840

tatacgcaaa aaagtttgtc tctctctccg ggg                                   873


<210>  819
<211>  1077
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  819
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gctcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcgg gatccggtgg aggagggtca      180

gagcccaaaa gctccgacaa gactcacaca tgcccccctt gtccagcgcc tgaagctgag      240

ggtgcgccct ctgtcttcct tttcccccct aagccgaaag ataccctgat gatctcccgc      300

actcccgaag tcacatgtgt tgttgtcgac gtatctcatg aagatcctga ggtgaaattc      360

aactggtatg tagacggggt cgaagttcat aatgctaaga ctaagccacg agaagagcaa      420

tacaactcaa cgtatcgggt ggtgagcgtt ctgacggttc tgcaccaaga ttggcttaat      480

ggaaaagagt ataagtgcaa ggtgtccaac aaggctcttc cggcacccat cgaaaagacg      540

atttccaaag cgaaaggcca acctagggaa ccgcaagttt acactttgcc cccgtcaaga      600

gacgaactta ccaagaatca agtttccctg acgtgccttg tgaagggctt ctaccctagc      660

gatatagcag ttgagtggga atctaacggc cagcccgaaa ataattataa gactactccg      720

cccgtgctgg acagtgatgg ttcatttttc ctgtattcaa aactcactgt ggacaaatct      780

agatggcagc agggtaatgt gttctcttgt tcagttatgc acgaggcatt gcacaatcac      840

tatacgcaaa aaagtttgtc tctctctccg gggggaggtg gtggatcagg cggtggaggt      900

tccggaggag gtggatctct gcaaatggcg ggacagtgta gtcaaaatga gtacttcgac      960

gcccttcttt acgcctgtat tccgtgccaa ctgcggtgca gcagtaacac gccaccgctc     1020

acttgccagc agtattgtaa tgccagtgta actaacagtg taaaagggac taatgct        1077


<210>  820
<211>  1077
<212>  DNA
<213>  artificial sequence

<220>
<223>  variant BCMA Fc

<400>  820
ctgcaaatgg ccgggcagtg cagccagaac gaatactttg actccttgtt gctcgcatgt       60

attccttgcc aactgcgctg ttcaagcaac acccccccgc tcacgtgtca gcggtactgc      120

aacgcatctg ttaccaacag tgtcaaaggg actaatgcgg gaggtggtgg atcaggcggt      180

ggaggttccg gaggaggtgg atctctgcaa atggcgggac agtgtagtca aaatgagtac      240

ttcgacagcc ttcttctcgc ctgtattccg tgccaactgc ggtgcagcag taacacgcca      300

ccgctcactt gccagaggta ttgtaatgcc agtgtaacta acagtgtaaa agggactaat      360

gctggatccg gtggaggagg gtcagagccc aaaagctccg acaagactca cacatgcccc      420

ccttgtccag cgcctgaagc tgagggtgcg ccctctgtct tccttttccc ccctaagccg      480

aaagataccc tgatgatctc ccgcactccc gaagtcacat gtgttgttgt cgacgtatct      540

catgaagatc ctgaggtgaa attcaactgg tatgtagacg gggtcgaagt tcataatgct      600

aagactaagc cacgagaaga gcaatacaac tcaacgtatc gggtggtgag cgttctgacg      660

gttctgcacc aagattggct taatggaaaa gagtataagt gcaaggtgtc caacaaggct      720

cttccggcac ccatcgaaaa gacgatttcc aaagcgaaag gccaacctag ggaaccgcaa      780

gtttacactt tgcccccgtc aagagacgaa cttaccaaga atcaagtttc cctgacgtgc      840

cttgtgaagg gcttctaccc tagcgatata gcagttgagt gggaatctaa cggccagccc      900

gaaaataatt ataagactac tccgcccgtg ctggacagtg atggttcatt tttcctgtat      960

tcaaaactca ctgtggacaa atctagatgg cagcagggta atgtgttctc ttgttcagtt     1020

atgcacgagg cattgcacaa tcactatacg caaaaaagtt tgtctctctc tccgggg        1077


<210>  821
<211>  522
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant Fc

<400>  821

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly 
225                 230                 235                 240 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
    290                 295                 300                 


Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro 
305                 310                 315                 320 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                325                 330                 335     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
            340                 345                 350         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        355                 360                 365             


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    370                 375                 380                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
385                 390                 395                 400 


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                405                 410                 415     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
            420                 425                 430         


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        435                 440                 445             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    450                 455                 460                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
465                 470                 475                 480 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                485                 490                 495     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            500                 505                 510         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        515                 520         


<210>  822
<211>  222
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant Fc

<400>  822

Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ser Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220         


<210>  823
<211>  228
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant Fc

<400>  823

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe 
1               5                   10                  15      


Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
            20                  25                  30          


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
        35                  40                  45              


Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val 
    50                  55                  60                  


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser 
65                  70                  75                  80  


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
                85                  90                  95      


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser 
            100                 105                 110         


Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
        115                 120                 125             


Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln 
    130                 135                 140                 


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
145                 150                 155                 160 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
                165                 170                 175     


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu 
            180                 185                 190         


Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser 
        195                 200                 205             


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
    210                 215                 220                 


Leu Ser Leu Gly 
225             


<210>  824
<211>  226
<212>  PRT
<213>  artificial sequence

<220>
<223>  variant Fc

<400>  824

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly 
1               5                   10                  15      


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


