                         SEQUENCE LISTING

<110>  DRAGONFLY THERAPEUTICS, INC.
 
<120>  PROTEINS BINDING NKG2D, CD16 AND CLEC12A

<130>  14247-540-228

<140>  TBA
<141>  

<150>  US 63/020,798
<151>  2020-05-06

<160>  342   

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of ADI-27705, 27724, 27740 [A40], 27741, 27743, 28154, 
28226, 29399, 29401, 29403, 29405, 29407, 29419, 29421, 29424, 
29425, 29426, 29429, 29404 [F04] and 29447 [F47]

<400>  1

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27705 VH CDR1

<400>  2

Gly Ser Phe Ser Gly Tyr Tyr Trp Ser 
1               5                   


<210>  3
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27705 VH CDR2

<400>  3

Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  4
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27705 VH CDR3

<400>  4

Ala Arg Ala Arg Gly Pro Trp Ser Phe Asp Pro 
1               5                   10      


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27705

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  6
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27724

<400>  6

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Ile Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  7
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27740 [A40]

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Phe Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  8
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27741 

<400>  8

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Asn Ser Tyr Tyr Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  9
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27743 

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  10
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of ADI-28153 

<400>  10

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp His Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Arg Gly Pro Trp Gly Phe Asp Pro Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  11
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-28153 

<400>  11

Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Thr Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ser Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Ile Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-28226 [C26]  

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Phe Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-28154 

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys Glu Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29399

<400>  14

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  15
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29401

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ile Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  16
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29403

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  17
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29405

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gly Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  18
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29407

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  19
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29419

<400>  19

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Ser Phe Ser Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  20
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29421

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Ser Tyr Ser Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  21
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29424

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Ser Phe Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  22
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29425

<400>  22

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Gln Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  23
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29426

<400>  23

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Phe Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  24
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29429

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Glu Leu Tyr Ser Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29447 [F47]

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Thr Phe Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  26
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of ADI-27727

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asp Ser Ser Ile Arg His Ala Tyr Tyr Tyr Tyr Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27727 and ADI-28200 VH CDR1 

<400>  27

Gly Thr Phe Ser Ser Tyr Ala Ile Ser 
1               5                   


<210>  28
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27727 VH CDR1 

<400>  28

Ser Tyr Ala Ile Ser 
1               5   


<210>  29
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27727 and ADI-28200 VH CDR2

<400>  29

Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  30
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27727 VH CDR3 

<400>  30

Ala Arg Gly Asp Ser Ser Ile Arg His Ala Tyr Tyr Tyr Tyr Gly Met 
1               5                   10                  15      


Asp Val 
        


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27727 VH CDR3 

<400>  31

Gly Asp Ser Ser Ile Arg His Ala Tyr Tyr Tyr Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  32
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27727 

<400>  32

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Ile Thr Phe Gly Gly Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27727 CDR1

<400>  33

Lys Ser Ser Gln Ser Val Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  34
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27727 and 28200 CDR2

<400>  34

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  35
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27727 CDR3

<400>  35

Gln Gln Tyr Tyr Ser Thr Pro Ile Thr 
1               5                   


<210>  36
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29443 [F43] VH

<400>  36

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


Ser Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Gly Ser Asp Arg Phe His Pro Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  37
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29443 [F43] VH CDR1 

<400>  37

Gly Ser Ile Ser Ser Ser Ser Tyr Tyr Trp Gly 
1               5                   10      


<210>  38
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29443 [F43] VH CDR1 

<400>  38

Ser Ser Ser Tyr Tyr Trp Gly 
1               5           


<210>  39
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29443 [F43] VH CDR2

<400>  39

Ser Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  40
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29443 [F43] VH CDR3 

<400>  40

Ala Arg Gly Ser Asp Arg Phe His Pro Tyr Phe Asp Tyr 
1               5                   10              


<210>  41
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29443 [F43] VH CDR3 

<400>  41

Gly Ser Asp Arg Phe His Pro Tyr Phe Asp Tyr 
1               5                   10      


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29443 [F43]

<400>  42

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Phe Asp Thr Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29443 [F43] CDR1

<400>  43

Arg Ala Ser Gln Ser Val Ser Arg Tyr Leu Ala 
1               5                   10      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29378[E78] and 29443[F43] CDR2

<400>  44

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29443 [F43] CDR3

<400>  45

Gln Gln Phe Asp Thr Trp Pro Pro Thr 
1               5                   


<210>  46
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29404 [F04] 

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Glu Gln Tyr Asp Ser Tyr Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  47
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-28200 VH

<400>  47

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Gly Arg Lys Ala Ser Gly Ser Phe Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-28200 VH CDR3

<400>  48

Ala Arg Arg Gly Arg Lys Ala Ser Gly Ser Phe Tyr Tyr Tyr Tyr Gly 
1               5                   10                  15      


Met Asp Val 
            


<210>  49
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-28200

<400>  49

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Glu Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Gly Asn Gln Lys Asn Tyr Leu Thr Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Pro Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Asn 
                85                  90                  95      


Asp Tyr Ser Tyr Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-28200 CDR1

<400>  50

Glu Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Thr 
    


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-28200 CDR3

<400>  51

Gln Asn Asp Tyr Ser Tyr Pro Tyr Thr 
1               5                   


<210>  52
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29379 [E79] VH

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Asn Tyr Gly Asp Thr Thr His Asp Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  53
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29378[78] and ADI-29379[E79] VH CDR1

<400>  53

Tyr Thr Phe Thr Ser Tyr Tyr Met His 
1               5                   


<210>  54
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29378 [78] and ADI-29379 [E79] VH CDR1

<400>  54

Ser Tyr Tyr Met His 
1               5   


<210>  55
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29378 [78] and ADI-29379 [E79] VH CDR2

<400>  55

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  56
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29379 [E79] VH CDR3

<400>  56

Ala Arg Gly Ala Pro Asn Tyr Gly Asp Thr Thr His Asp Tyr Tyr Tyr 
1               5                   10                  15      


Met Asp Val 
            


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29379 [E79] VH CDR3

<400>  57

Gly Ala Pro Asn Tyr Gly Asp Thr Thr His Asp Tyr Tyr Tyr Met Asp 
1               5                   10                  15      


Val 
    


<210>  58
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29379 [E79]

<400>  58

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Asp Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29379 [E79] and 29463 [F63] CDR1

<400>  59

Arg Ala Ser Gln Ser Val Ser Ser Asn Leu Ala 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29379 [E79] and 29463 [F63] CDR2

<400>  60

Gly Ala Ser Thr Arg Ala Thr 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29379 [E79] CDR3

<400>  61

Gln Gln Tyr Asp Asp Trp Pro Phe Thr 
1               5                   


<210>  62
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29463 [F63] VH

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Thr Gly Glu Tyr Tyr Asp Thr Asp Asp His Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29379 [E79] VH CDR3

<400>  63

Tyr Thr Phe Thr Gly Tyr Tyr Met His 
1               5                   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29463 [F63] VH CDR1

<400>  64

Gly Tyr Tyr Met His 
1               5   


<210>  65
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29463 [F63] VH CDR2

<400>  65

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  66
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29463 [F63] VH CDR3

<400>  66

Ala Arg Asp Thr Gly Glu Tyr Tyr Asp Thr Asp Asp His Gly Met Asp 
1               5                   10                  15      


Val 
    


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29463 [F63] VH CDR3

<400>  67

Asp Thr Gly Glu Tyr Tyr Asp Thr Asp Asp His Gly Met Asp Val 
1               5                   10                  15  


<210>  68
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29463 [F63]

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Asp Tyr Trp Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  69
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29463 [F63] CDR3

<400>  69

Gln Gln Asp Asp Tyr Trp Pro Pro Thr 
1               5                   


<210>  70
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27744 [A44] VH

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Gly Tyr Tyr Asp Ser Gly Ala Gly Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120      


<210>  71
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27744 [A44] VH CDR1 

<400>  71

Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27744 [A44] VH CDR2

<400>  72

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  73
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27744[A44] VH CDR3 

<400>  73

Ala Lys Asp Gly Gly Tyr Tyr Asp Ser Gly Ala Gly Asp Tyr 
1               5                   10                  


<210>  74
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27744 [A44] VH CDR3 

<400>  74

Asp Gly Gly Tyr Tyr Asp Ser Gly Ala Gly Asp Tyr 
1               5                   10          


<210>  75
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27744 [A44]

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Asp Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Ser Tyr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  76
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27744 [A44] CDR1

<400>  76

Arg Ala Ser Gln Gly Ile Asp Ser Trp Leu Ala 
1               5                   10      


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27744 [A44], 27749 [A49], A49MI, A49MQ, A49ML,
 A49MF, A49MV and A49-consensus CDR2

<400>  77

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-27744 [A44] CDR3

<400>  78

Gln Gln Gly Val Ser Tyr Pro Arg Thr 
1               5                   


<210>  79
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49] VH

<400>  79

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Met Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49], A49MI, A49MQ, A49ML, A49MF, A49MV and 
A49-consensus VH CDR1 

<400>  80

Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   


<210>  81
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749[A49], A49MI, A49MQ, A49ML, A49MF, A49MV and 
A49-consensus VH CDR1 

<400>  81

Ser Tyr Ser Met Asn 
1               5   


<210>  82
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49], A49MI, A49MQ, A49ML, A49MF, A49MV 
and A49-consensus VH CDR2

<400>  82

Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  83
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49] VH CDR3 

<400>  83

Ala Arg Gly Ala Pro Met Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  84
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49] VH CDR3 

<400>  84

Gly Ala Pro Met Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10              


<210>  85
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49], A49MI, A49MQ, A49ML, A49MF, A49MV 
and A49-consensus VL

<400>  85

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49], A49MI, A49MQ, A49ML, A49MF, A49MV and 
A49-consensus VL CDR1

<400>  86

Arg Ala Ser Gln Gly Ile Ser Ser Trp Leu Ala 
1               5                   10      


<210>  87
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49], A49MI, A49MQ, A49ML, A49MF, A49MV and 
A49-consensus VL CDR3

<400>  87

Gln Gln Gly Val Ser Phe Pro Arg Thr 
1               5                   


<210>  88
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27749 [A49] -scFv (VL-VH) with Q44C in VH and G100C in VL

<400>  88

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser 
145                 150                 155                 160 


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Gly Ala Pro Met Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  89
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29378 [E78] VH

<400>  89

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Ala Gly Phe Ala Tyr Gly Met Asp Tyr Tyr Tyr Met 
            100                 105                 110         


Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  90
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29378 [E78] VH CDR3 

<400>  90

Ala Arg Glu Gly Ala Gly Phe Ala Tyr Gly Met Asp Tyr Tyr Tyr Met 
1               5                   10                  15      


Asp Val 
        


<210>  91
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-29378 [E78] VH CDR3 

<400>  91

Glu Gly Ala Gly Phe Ala Tyr Gly Met Asp Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15      


<210>  92
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29378 [E78]

<400>  92

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asp Asn Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  93
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29378 [E78] CDR1

<400>  93

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of ADI-29378 [E78] CDR3

<400>  94

Gln Gln Ser Asp Asn Trp Pro Phe Thr 
1               5                   


<210>  95
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MI VH

<400>  95

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Ile Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  96
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MI VH CDR3 

<400>  96

Ala Arg Gly Ala Pro Ile Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  97
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MI VH CDR3 

<400>  97

Gly Ala Pro Ile Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10              


<210>  98
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MQ VH

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Gln Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  99
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MQ VH CDR3 

<400>  99

Ala Arg Gly Ala Pro Gln Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  100
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MQ VH CDR3 

<400>  100

Gly Ala Pro Gln Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10              


<210>  101
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49ML VH

<400>  101

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Leu Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  102
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49ML VH CDR3 

<400>  102

Ala Arg Gly Ala Pro Leu Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  103
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49ML VH CDR3

<400>  103

Gly Ala Pro Leu Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10              


<210>  104
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MF VH

<400>  104

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Phe Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  105
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MF VH CDR3 

<400>  105

Ala Arg Gly Ala Pro Phe Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  106
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MF VH CDR3 

<400>  106

Gly Ala Pro Phe Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10              


<210>  107
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MV VH

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Val Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MV VH CDR3

<400>  108

Ala Arg Gly Ala Pro Val Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MV VH CDR3 

<400>  109

Gly Ala Pro Val Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10              


<210>  110
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49-consensus VH

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be Met, Leu, Ile, Val, Gln or Phe

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Xaa Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  111
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49-consensus VH CDR3

<220>  
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Met, Leu, Ile, Val, Gln or Phe

<400>  111

Ala Arg Gly Ala Pro Xaa Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  15  


<210>  112
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49-consensus VH CDR3

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be Met, Leu, Ile, Val, Gln or Phe

<400>  112

Gly Ala Pro Xaa Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10              


<210>  113
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D binder in US 9,273,136 

<400>  113

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Arg Gly Leu Gly Asp Gly Thr Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  114
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D binder in US 9,273,136

<400>  114

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asp Asp Leu Leu Pro Ser Gly Val Ser Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Phe Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210>  115
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ADI-27744 [A44] VH CDR1 

<400>  115

Ser Tyr Ala Met Ser 
1               5   


<210>  116
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D binder in US 7,879,985 

<400>  116

Gln Val His Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Asp Asp Ser Ile Ser Ser Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly His Ile Ser Tyr Ser Gly Ser Ala Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Asn Trp Asp Asp Ala Phe Asn Ile Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  117
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D binder in US 7,879,985

<400>  117

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  118
<211>  226
<212>  PRT
<213>  Homo sapiens

<220>
<223>  wild-type human IgG1 Fc sequence

<400>  118

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  119
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  119

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  120
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<220>
<221>  REPEAT
<222>  (1)..(2)
<223>  sequence can be repeated 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 
       13, 14, 15, 16, 17, 18, 19, or 20 times

<400>  120

Gly Ser 
1       


<210>  121
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<220>
<221>  REPEAT
<222>  (1)..(3)
<223>  sequence can be repeated 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 
       13, 14, 15, 16, 17, 18, 19, or 20 times

<400>  121

Gly Gly Ser 
1           


<210>  122
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  sequence can be repeated 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 
       13, 14, 15, 16, 17, 18, 19, or 20 times

<400>  122

Gly Gly Gly Ser 
1               


<210>  123
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  sequence can be repeated 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 
       13, 14, 15, 16, 17, 18, 19, or 20 times

<400>  123

Gly Gly Ser Gly 
1               


<210>  124
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  sequence can be repeated 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 
       13, 14, 15, 16, 17, 18, 19, or 20 times

<400>  124

Gly Gly Ser Gly Gly 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  sequence can be repeated 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 
       13, 14, 15, 16, 17, 18, 19, or 20 times

<400>  125

Gly Gly Gly Gly Ser 
1               5   


<210>  126
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  126

Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210>  127
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  127

Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly 
1               5                   10                  15      


Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser 
            20                  25                  30  


<210>  128
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  128

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Ser Gly Gly Gly Ser 
        35                  40  


<210>  129
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  129

Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Ser Gly 
        35                  40  


<210>  130
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  130

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly 
    50  


<210>  131
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  131

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser 
    50  


<210>  132
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  132

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  133
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  133

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        35                  40                  45              


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    50                  55                  60                  


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
65                  70                  75                  80  


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
                85                  90                  95      


Gly Gly Gly Ser 
            100 


<210>  134
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker sequence

<400>  134

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40                  45              


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    50                  55                  60                  


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
65                  70                  75                  80  


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                85                  90                  95      


Gly Ser Gly Gly 
            100 


<210>  135
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of 16B8.C8

<400>  135

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Thr Pro Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Ile Ser Lys Asn Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Pro Asn Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  136
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of 16B8.C8

<400>  136

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Ala Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  137
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 - VH CDR1

<400>  137

Gly Phe Ser Leu Thr Asn Tyr 
1               5           


<210>  138
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 - VH CDR2

<400>  138

Trp Ser Gly Gly Lys 
1               5   


<210>  139
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 - VH CDR3

<400>  139

Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr 
1               5                   


<210>  140
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 - VL CDR1

<400>  140

His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser 
1               5                   10      


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 - VL CDR2

<400>  141

Glu Ala Ser Asn Leu His Thr 
1               5           


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 - VL CDR3

<400>  142

Gln Gln Ser His Ser Tyr Pro Leu Thr 
1               5                   


<210>  143
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1292/scFv-1301, scFv-1297/scFv-1306, 
scFv-1298/scFv-1307 and scFv-1299/scFv-1308 - VH

<400>  143

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  144
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1293/scFv-1302, scFv-1294/scFv-1303,
 scFv-1295/scFv-1304 and scFv-1296/scFv-1305 VL

<400>  144

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  145
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1292 [VH-VL]:

<400>  145

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  146
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1301 [VL-VH]

<400>  146

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  147
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1293/scFv-1302 VH

<400>  147

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  148
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0192/AB0186 and AB0195/AB0189 VH

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  149
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1293 [VH-VL]

<400>  149

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  150
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1302 [VL-VH]

<400>  150

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  151
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 consensus

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be Ala or Ile

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be Asp or Arg

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be Phe or Ile

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be Gln or Gly

<400>  151

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Xaa Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  152
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 VL CDR1

<400>  152

Lys Ser Ser Gln Ser Leu Leu Trp Asn Val Asn Gln Asn Asn Tyr Leu 
1               5                   10                  15      


Val 
    


<210>  153
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1294 [VH-VL]

<400>  153

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  154
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1303 [VL-VH]

<400>  154

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  155
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VH

<400>  155

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Ile Lys Leu Ser Cys Ala Ala Ser Ala Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Asp Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Leu Trp Ser Arg Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  156
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1295 [VH-VL]

<400>  156

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  157
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1304  [VL-VH]

<400>  157

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  158
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VL

<400>  158

Glu Val Leu Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ile Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Tyr Phe Ser Phe Thr Ile Asn Asn Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Tyr Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  159
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VH CDR1

<400>  159

Ala Phe Asn Ile Lys Asp Tyr 
1               5           


<210>  160
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1296 [VH-VL]

<400>  160

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  161
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1305 [VL-VH]

<400>  161

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  162
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0191/AB0185 and AB0194/AB0188 VH

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  163
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1297 / scFv-1306 VL

<400>  163

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  164
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1297 [VH-VL]

<400>  164

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  165
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1306 [VL-VH]

<400>  165

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  166
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 and 30A9.E9 VH CDR2

<400>  166

Trp Ser Gly Gly Ser 
1               5   


<210>  167
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1298 / scFv-1307 VL

<400>  167

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  168
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1298 [VH-VL]

<400>  168

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  169
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1307 [VL-VH]

<400>  169

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  170
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VH CDR2

<400>  170

Asp Pro Glu Asn Asp Asp 
1               5       


<210>  171
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1299 / scFv-1308

<400>  171

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  172
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1299 [VH-VL]

<400>  172

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  173
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1308 [VL-VH]

<400>  173

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  174
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1300/ scFv-1309 - VH

<400>  174

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  175
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1300/ scFv-1309

<400>  175

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  176
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1300 [VH-VL]

<400>  176

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  177
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1309 [VL-VH]

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  178
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1295/scFv-1304 and 
scFv-1602/scFv-2061 VH

<400>  178

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  179
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8, 23A5.H8 and 30A9.E9 VL CDR3

<400>  179

Gln His Asn His Gly Ser Phe Leu Pro Tyr Thr 
1               5                   10      


<210>  180
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv -1602 [VH-VL]

<400>  180

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  181
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized 16B8.C8 of scFv-2061 [VL-VH]

<400>  181

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  182
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 consensus - VH

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be Val or Lys

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be Thr or Gln 

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa can be Ala or Asn

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be Arg or Lys

<400>  182

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Xaa Ala Xaa Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Xaa Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  183
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VH CDR3

<400>  183

Leu Trp Ser Arg Gly Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  184
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0191 [VH-VL]

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  185
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0185 [VL-VH]

<400>  185

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  186
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VL CDR1

<400>  186

Ser Ala Arg Ser Ser Val Ser Tyr Met Ser 
1               5                   10  


<210>  187
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 VH CDR3

<400>  187

Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr 
1               5                   10      


<210>  188
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VL CDR2

<400>  188

Gly Ile Ser Lys Leu Ala Ser 
1               5           


<210>  189
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VL CDR3

<400>  189

Gln Gln Arg Ser Tyr Tyr Pro Phe Thr 
1               5                   


<210>  190
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VH

<400>  190

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Tyr Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Tyr Gly Ser Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  191
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VL

<400>  191

Ser Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Ile Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  192
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7, AB0193/AB0187 and AB0196/AB0190 VH CDR1

<400>  192

Gly Phe Thr Phe Asn Ser Phe 
1               5           


<210>  193
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11.B7 VH

<400>  193

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  194
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11.B7 VL

<400>  194

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Leu Lys Pro Gly Lys Ser Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  195
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0192/AB0186, AB0195/AB0189 VH CDR1

<400>  195

Gly Phe Thr Phe Asn Ala Phe 
1               5           


<210>  196
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7, AB0193/AB0187, AB0195/AB0189, in AB0192/AB0186,
 AB0196/AB0190 and 9F11.B7 consensus VH CDR2

<400>  196

Ser Ser Gly Ser Thr Ser 
1               5       


<210>  197
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VH CDR1

<400>  197

Gly Tyr Ser Phe Thr Ala Tyr 
1               5           


<210>  198
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11.B7 VL CDR1

<400>  198

Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser 
1               5                   10      


<210>  199
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11.B7 VL CDR2

<400>  199

Arg Ala Asn Ile Leu Val Ser 
1               5           


<210>  200
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 16B8.C8 of AB7410 [VL-VH]

<400>  200

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Leu Ser Gly Gly Trp Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Gly Asp Tyr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11.B7 VL CDR3

<400>  201

Leu Gln Phe Asp Ala Phe Pro Phe Thr 
1               5                   


<210>  202
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VH CDR2

<400>  202

Asp Pro Ser Tyr Gly Asp 
1               5       


<210>  203
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0191/AB0185, AB0192/AB0186, 
AB0193/AB0187 VL

<400>  203

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  204
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0192 [VH-VL]

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  205
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0186 [VL-VH]

<400>  205

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  206
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VH CDR1

<400>  206

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  207
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VH CDR3

<400>  207

Asp Asn Tyr Tyr Gly Ser Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  208
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0193 [VH-VL]

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  209
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0187 [VL-VH]

<400>  209

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  210
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0193/AB0187 and AB0196/AB0190 VH

<400>  210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  211
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VL CDR1

<400>  211

Arg Ser Ser Gln Gly Ile Val His Ile Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  212
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VL CDR2

<400>  212

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  213
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0193/AB0187 and AB0196/AB0190 VH CDR3

<400>  213

Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr 
1               5                   10      


<210>  214
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VL CDR3

<400>  214

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  215
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0194 [VH-VL]

<400>  215

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  216
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0188 [VL-VH]

<400>  216

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  217
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VH

<400>  217

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Asn Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Ser Tyr Tyr Tyr Asp Ser Ser Ser Arg Tyr Val Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  218
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0194/AB0188, AB0195/AB0189 and 
AB0196/AB0190 VL

<400>  218

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  219
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VL

<400>  219

Gly Ile Val Met Thr Gln Ala Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Phe Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Ser Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Leu 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VH CDR1

<400>  220

Gly Phe Asn Ile Lys Asp Tyr 
1               5           


<210>  221
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 and 30A9.E9 VH CDR1

<400>  221

Gly Phe Ser Leu Thr Ser Phe 
1               5           


<210>  222
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VH CDR2

<400>  222

Asp Pro Glu Asn Gly Asp 
1               5       


<210>  223
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 and 30A9.E9 VH CDR3

<400>  223

Ser Tyr Phe Ala Met Asp Tyr 
1               5           


<210>  224
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VL CDR1

<400>  224

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Phe Leu Asn 
1               5                   10                  15      


<210>  225
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VL CDR2

<400>  225

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  226
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 and 30A9.E9 VL CDR2

<400>  226

Gly Ala Ser Ile Arg Glu Ser 
1               5           


<210>  227
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VL CDR3

<400>  227

Trp Gln Gly Thr His Phe Pro Tyr Thr 
1               5                   


<210>  228
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VH

<400>  228

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Thr Thr Gly Tyr Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly Arg Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Glu Leu Phe Pro Gly Asn Ser Asp Thr Thr Leu Asn Glu Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Thr Phe Thr Ala Asp Ser Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  229
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VL

<400>  229

Gly Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Gly Glu Asn Ile His Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  230
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VH CDR1

<400>  230

Gly Tyr Thr Phe Ser Thr Tyr 
1               5           


<210>  231
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VH CDR2

<400>  231

Phe Pro Gly Asn Ser Asp 
1               5       


<210>  232
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VH CDR3

<400>  232

Ser Gly Tyr Tyr Gly Ser Ser Leu Asp Tyr 
1               5                   10  


<210>  233
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VL CDR1

<400>  233

Arg Ala Gly Glu Asn Ile His Ser Tyr Leu Ala 
1               5                   10      


<210>  234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VL CDR2

<400>  234

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  235
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VL CDR3

<400>  235

Gln His His Tyr Gly Thr Pro Arg Thr 
1               5                   


<210>  236
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 VH CDR2

<400>  236

Trp Ser Gly Gly Asn 
1               5   


<210>  237
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 VL

<400>  237

Gly Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Leu Trp Asn 
            20                  25                  30          


Val Asn Gln Asn Asn Tyr Leu Val Trp Tyr Gln Gln Lys Gln Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Trp Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val His Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  238
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 VH

<400>  238

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Ser Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Ile Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Val Thr Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  239
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VL CDR2

<400>  239

Gly Ala Ser Ile Arg Gln Ser 
1               5           


<210>  240
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30A9.E9 VL CDR1

<400>  240

Lys Ser Ser Gln Ser Leu Leu Trp Asn Val Asn Gln Asn Asn Tyr Leu 
1               5                   10                  15      


Leu 
    


<210>  241
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VH CDR3

<400>  241

Thr His Phe Gly Met Asp Tyr 
1               5           


<210>  242
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VH 

<400>  242

Gln Val Gln Leu Arg Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Thr Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr His Phe Gly Met Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  243
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VL

<400>  243

Gly Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Leu Trp Ser 
            20                  25                  30          


Val Asn Gln Asn Asn Tyr Leu Leu Trp Tyr Gln Gln Lys Gln Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Gln Ser Trp Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
65                  70                  75                  80  


Ile Ser Asn Val His Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  244
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8  in scFv-1294 / scFv-1303 VH

<400>  244

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  245
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VL CDR1

<400>  245

Lys Ser Ser Gln Ser Leu Leu Trp Ser Val Asn Gln Asn Asn Tyr Leu 
1               5                   10                  15      


Leu 
    


<210>  246
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 consensus VH CDR3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Asp or Ser

<400>  246

Xaa Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr 
1               5                   10      


<210>  247
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30A9.E9 VH

<400>  247

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Ser Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Thr Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Ser 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  248
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30A9.E9 VL

<400>  248

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Leu Trp Asn 
            20                  25                  30          


Val Asn Gln Asn Asn Tyr Leu Leu Trp Tyr Gln Gln Lys Gln Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Trp Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val His Val Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  249
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 consensus - VH

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be Ser or Ala

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa can be Asp or Ser

<400>  249

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Xaa Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  250
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 consensus

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be Gln or Lys

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be Phe or Leu

<400>  250

Asp Ile Xaa Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Xaa Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Trp His Glu Arg Glu 
            100                 105                 110         


Ile Asn 
        


<210>  251
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 consensus VH CDR1

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Ser or Ala

<400>  251

Gly Phe Thr Phe Asn Xaa Phe 
1               5           


<210>  252
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0195 [VH-VL]

<400>  252

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  253
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0189 [VL-VH]

<400>  253

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  254
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0196 [VH-VL]

<400>  254

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  255
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 9F11.B7 of AB0190 [VL-VH]

<400>  255

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  256
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8  in scFv-1296/scFv-1305, scFv-1297/scFv-1306 -VH

<400>  256

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  257
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VH CDR3

<400>  257

Tyr Tyr Tyr Asp Ser Ser Ser Arg Tyr Val Asp Val 
1               5                   10          


<210>  258
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Uniprot ID No. Q5QGZ9

<400>  258

Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser 
1               5                   10                  15      


Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro 
            20                  25                  30          


Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu 
        35                  40                  45              


Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe 
    50                  55                  60                  


His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
65                  70                  75                  80  


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
                85                  90                  95      


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
            100                 105                 110         


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
        115                 120                 125             


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
    130                 135                 140                 


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
145                 150                 155                 160 


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
                165                 170                 175     


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
            180                 185                 190         


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
        195                 200                 205             


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
    210                 215                 220                 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
225                 230                 235                 240 


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
                245                 250                 255     


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
            260                 265 


<210>  259
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1602-VH-VL-Fc [Chain S]

<400>  259

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  260
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MI-VH-CH1-Fc [Chain H] 

<400>  260

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Pro Ile Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Cys Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Glu Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Trp Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly 
    450     


<210>  261
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A49MI-VL-CL [Chain L]

<400>  261

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  262
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-2061-VL-VH-Fc 

<400>  262

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  263
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAb Merus-CLL1 -VH 

<400>  263

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Gly Asp Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  264
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAb Merus-CLL1 - VL

<400>  264

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  265
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAb Genentech-h6E7 - VH 

<400>  265

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  266
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAb Genentech-h6E7 - VL 

<400>  266

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Ala Phe Tyr Ser Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Glu Arg Gly Ala Asp Leu Glu Gly Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  267
<211>  1485
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv-1602-VH-VL-Fc

<400>  267
atggacatga gggtaccagc tcagctgctg ggcctgctgc tgctttggct tcctggcgct       60

agatgccaat tgcagctgca agaatccgga ccagggctcg taaaaccttc tgaaaccctc      120

tccctcactt gcactgtgtc tggattctct ctcacgaact acgggttgca ttggatccga      180

cagccgcctg gcaagtgtct tgagtggatt ggcgttatct ggtcaggagg gaagacggat      240

tataatccaa gtctgaaatc cagagtgaca atttctaagg acacgtccaa aaatcagttt      300

agcctcaaac tttcctcagt tcaggctgct gatacagcgg tgtactattg cgcaaagtac      360

gactatgatg acagtttgga ctactgggga cagggtacac tggtaacagt gagttctgga      420

ggcggcggta gtggaggcgg gggaagtggt ggcggaggga gtggaggagg gggcagtgat      480

attcaaatga cgcagagccc cagttccctt tcagctagcg ttggcgacag agtaacgata      540

acgtgtcacg cttcccagaa cattaatttt tggcttagct ggtatcaaca gaaaccggga      600

aaagcaccca agctgcttat ctatgaagcg tccaatctcc acacgggtgt cccatcaaga      660

ttttctggat caggcagtgg cacacgattc acactgacca ttagttcctt gcagcccgag      720

gatatcgcaa cttactactg tcagcaaagt cactcttacc cgttgacatt cggatgtgga      780

actaaactgg agattaaggg atccgataag acccacacct gtcctccatg tcctgctcca      840

gaactgctcg gcggaccttc cgtgttcctg tttcctccaa agcctaagga caccctgatg      900

atcagcagga cccctgaagt gacctgcgtg gtggtggatg tgtctcacga ggacccagaa      960

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcctaga     1020

gaggaacagt acaacagcac ctacagagtg gtgtccgtgc tgaccgtgct gcaccaggat     1080

tggctgaacg gcaaagagta caagtgcaag gtgtccaaca aggccctgcc tgctcctatc     1140

gagaaaacca tcagcaaggc caagggccag cctcgcgagc ctagagtgta taccttgcct     1200

ccatgccggg acgagctgac caagaatcag gtgtccctga cctgcctggt caagggcttc     1260

tacccttccg atatcgccgt ggaatgggag agcaatggcc agccagagaa caactacaag     1320

accacacctc ctgtgctggt gtccgacggc agctttaccc tgtacagcaa gctgacagtg     1380

gacaagagca gatggcagca gggcaacgtg ttctcctgca gcgtgatgca cgaggccctg     1440

cacaaccact acacccagaa aagcctgagc ctgtctcctg gctaa                     1485


<210>  268
<211>  1413
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A49MI-VH-CH1-Fc

<400>  268
atgggctggt cctgcatcat cctgtttctg gtggccacag ccacaggcgt gcactctgag       60

gtgcagctgg ttgaatctgg cggcggactt gtgaagcctg gcggatctct gagactgagc      120

tgtgccgcca gcggcttcac ctttagcagc tacagcatga actgggtccg acaggcccct      180

ggcaaaggcc ttgaatgggt gtccagcatc agcagcagct ccagctacat ctactacgcc      240

gacagcgtga agggcagatt caccatcagc cgggacaacg ccaagaacag cctgtacctg      300

cagatgaact ccctgagagc cgaggacacc gccgtgtact attgtgctag aggcgcccct      360

attggagccg ccgctggatg gttcgatcct tggggacagg gaaccctggt caccgtttct      420

tctgcctcta caaagggccc cagcgttttc ccactggctc ctagcagcaa gagcacaagc      480

ggaggaacag ctgccctggg ctgtctggtc aaggactact ttcctgagcc tgtgaccgtg      540

tcctggaaca gcggagcact gactagcggc gtgcacacat ttccagccgt gctgcaaagc      600

agcggcctgt actctctgag cagcgtcgtg acagtgccta gcagctctct gggcacccag      660

acctacatct gcaatgtgaa ccacaagcct agcaacacca aggtggacaa gaaggtggaa      720

cccaagagct gcgacaagac ccacacctgt cctccatgtc ctgctccaga actgctcggc      780

ggaccttccg tgttcctgtt tcctccaaag cctaaggaca ccctgatgat cagcagaacc      840

cctgaagtga cctgcgtggt ggtggatgtg tctcacgagg accccgaagt gaagttcaat      900

tggtacgtgg acggcgtgga agtgcacaac gccaagacca agcctagaga ggaacagtac      960

aacagcacct acagagtggt gtccgtgctg acagtgctgc accaggattg gctgaacggc     1020

aaagagtaca agtgcaaggt gtccaacaag gccctgcctg ctcctatcga gaaaaccatc     1080

agcaaggcca agggccagcc tcgcgaacct caagtctgta cactgcctcc tagccgggat     1140

gagctgaccg agaatcaggt gtccctgacc tgtctcgtga agggcttcta cccctccgat     1200

atcgccgtgg aatgggagag caatggccag ccagagaaca actacaagac aacccctcct     1260

gtgctggaca gcgacggctc attcttcctg tacagctggc tgaccgtgga caagtccaga     1320

tggcagcagg gcaacgtgtt ctcctgcagc gtgatgcacg aggccctgca caaccactac     1380

acccagaagt ccctgtctct gagcccaggc taa                                  1413


<210>  269
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A49MI-VL-CL

<400>  269
atggacatga gagttccagc tcagctgctg ggcctgctgc tgctttggct tcctggcgct       60

agatgcgaca tccagatgac acagagcccc agctccgtgt ctgcctctgt gggagacaga      120

gtgaccatca cctgtagagc cagccagggc atctcttctt ggctggcctg gtatcagcag      180

aagcctggca aggcccctaa gctgctgatc tatgccgcta gctctctgca gtctggcgtg      240

ccctctagat tttctggcag cggctctggc accgacttca ccctgaccat atctagcctg      300

cagcctgagg acttcgccac ctactattgt cagcagggcg tgtcctttcc acggaccttt      360

ggcggcggaa caaaggtgga aatcaagcgg acagtggccg ctcctagcgt gttcatcttt      420

ccacctagcg acgagcagct gaagtccggc acagcctctg ttgtgtgcct gctgaacaac      480

ttctacccca gagaagccaa ggtgcagtgg aaggtggaca atgccctgca gagcggcaac      540

agccaagaga gcgtgacaga gcaggacagc aaggactcca cctacagcct gagcagcacc      600

ctgacactga gcaaggccga ctacgagaag cacaaagtgt acgcctgcga agtgacccac      660

cagggccttt ctagccctgt gaccaagagc ttcaaccggg gcgagtgttg a               711


<210>  270
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/AB5030 - VH

<400>  270

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  271
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/AB5030

<400>  271

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  272
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/AB5030 VH - CDR2

<400>  272

Trp Val Gly Gly Ala 
1               5   


<210>  273
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/AB5030 VH - CDR3

<400>  273

Gly Asp Tyr Gly Asp Thr Leu Asp Tyr 
1               5                   


<210>  274
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 16B8.C8 of AB0305 [VH-VL]

<400>  274

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  275
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 16B8.C8 of AB5030 [VL-VH]

<400>  275

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  276
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0305-VH-VL-Fc

<400>  276

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  277
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0304-VH-VL-Fc 

<400>  277

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Leu Ser Gly Gly Trp Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  278
<211>  475
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0192-VH-VL-Fc 

<400>  278

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys Gly Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Cys Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly Ser 
            420                 425                 430         


Phe Thr Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475 


<210>  279
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0147/AB7410 VH CDR3

<400>  279

Gly Asp Tyr Gly Asp Ala Leu Asp Tyr 
1               5                   


<210>  280
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv of humanized 16B8.C8 of AB0147[VH-VL]

<400>  280

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Leu Ser Gly Gly Trp Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  281
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1295-VH-VL-Fc 

<400>  281

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Gly Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro Cys Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp Gly Ser Phe Thr Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470         


<210>  282
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TriNKET variants of A49-mutation

<400>  282

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Asn Ser Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Ser Thr Lys Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Asp Leu Pro Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  283
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of motif without the DS site in CDRH3 - 
binding analysis to hCLEC12A - AB0053

<400>  283

Tyr Asp Tyr Asp Asp Ala Leu Asp Tyr 
1               5                   


<210>  284
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of motif without the DS site in CDRH3 - 
binding analysis to hCLEC12A - AB0085

<400>  284

Tyr Asp Tyr Asp Asp Ile Leu Asp Tyr 
1               5                   


<210>  285
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of motif without the DS site in CDRH3

<400>  285

Tyr Asp Tyr Asp Asp Leu Leu Asp Tyr 
1               5                   


<210>  286
<211>  477
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-A49MI-VH-VL-Fc 

<400>  286

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly Val Ser Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser 
145                 150                 155                 160 


Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Gly Ala Pro Ile Gly Ala Ala Ala Gly Trp Phe Asp Pro Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Asp Lys Thr His Thr 
                245                 250                 255     


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
            260                 265                 270         


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
        275                 280                 285             


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
    290                 295                 300                 


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
305                 310                 315                 320 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
                325                 330                 335     


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
            340                 345                 350         


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
        355                 360                 365             


Lys Ala Lys Gly Gln Pro Arg Glu Pro Arg Val Tyr Thr Leu Pro Pro 
    370                 375                 380                 


Cys Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
385                 390                 395                 400 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
                405                 410                 415     


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Val Ser Asp 
            420                 425                 430         


Gly Ser Phe Thr Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
        435                 440                 445             


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
    450                 455                 460                 


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475         


<210>  287
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1602-VH-CH1-Fc 

<400>  287

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Cys Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Asp Glu Leu Thr Glu Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Trp Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445     


<210>  288
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  1602-VL-CL 

<400>  288

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  289
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1602/ scFv-2061

<400>  289

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  290
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant for binding analysis to hCLEC12A

<400>  290

Tyr Asp Tyr Asp Asp Val Leu Asp Tyr 
1               5                   


<210>  291
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant for binding analysis to hCLEC12A

<400>  291

Tyr Asp Tyr Asp Asp Thr Leu Asp Tyr 
1               5                   


<210>  292
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant for binding analysis to hCLEC12A

<400>  292

Tyr Asp Tyr Asp Glu Ser Leu Asp Tyr 
1               5                   


<210>  293
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv VH 

<400>  293

Asp Tyr Asp Asp Ser Leu Asp Tyr 
1               5               


<210>  294
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0147/AB7410

<400>  294

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Leu Ser Gly Gly Trp Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  295
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0147/AB7410

<400>  295

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  296
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0147/AB7410 VH CDR2

<400>  296

Leu Ser Gly Gly Trp 
1               5   


<210>  297
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F3'-1602 CDR H1- Chothia

<400>  297

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  298
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F3'-1602 CDR H2- Chothia

<400>  298

Ser Ser Ser Ser Ser Tyr 
1               5       


<210>  299
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in chain H of F3'-1602

<400>  299

Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ser Met Asn 
1               5                   10                  15      


Trp Val Arg 
            


<210>  300
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in chain H of F3'-1602

<400>  300

Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg 
1               5                   10      


<210>  301
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in chain H and S of F3'-1602

<400>  301

Asp Thr Leu Met Ile Ser Arg 
1               5           


<210>  302
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in chain H and S of F3'-1602

<400>  302

Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
1               5                   10                  15      


His Asn His Tyr Thr Gln Lys 
            20              


<210>  303
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in chain L of F3'-1602

<400>  303

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg 
        


<210>  304
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in chain S of F3'-1602

<400>  304

Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro 
        35                  40                  45              


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys His 
    50                  55                  60                  


Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys Pro 
65                  70                  75                  80  


Gly Lys Ala Pro Lys 
                85  


<210>  305
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  305

Xaa Asp Tyr Asp Asp Ser Leu Asp Tyr 
1               5                   


<210>  306
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  306

Tyr Xaa Tyr Asp Asp Ser Leu Asp Tyr 
1               5                   


<210>  307
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  307

Tyr Asp Xaa Asp Asp Ser Leu Asp Tyr 
1               5                   


<210>  308
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  308

Tyr Asp Tyr Xaa Asp Ser Leu Asp Tyr 
1               5                   


<210>  309
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  309

Tyr Asp Tyr Asp Xaa Ser Leu Asp Tyr 
1               5                   


<210>  310
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  310

Tyr Asp Tyr Asp Asp Xaa Leu Asp Tyr 
1               5                   


<210>  311
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  311

Tyr Asp Tyr Asp Asp Ser Xaa Asp Tyr 
1               5                   


<210>  312
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  312

Tyr Asp Tyr Asp Asp Ser Leu Xaa Tyr 
1               5                   


<210>  313
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  313

Tyr Asp Tyr Asp Asp Ser Leu Asp Xaa 
1               5                   


<210>  314
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  314

Xaa Xaa Tyr Asp Asp Ser Leu Asp Tyr 
1               5                   


<210>  315
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library(Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  315

Xaa Asp Xaa Asp Asp Ser Leu Asp Tyr 
1               5                   


<210>  316
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  316

Xaa Asp Tyr Xaa Asp Ser Leu Asp Tyr 
1               5                   


<210>  317
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  317

Xaa Asp Tyr Asp Xaa Ser Leu Asp Tyr 
1               5                   


<210>  318
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  318

Xaa Asp Tyr Asp Asp Xaa Leu Asp Tyr 
1               5                   


<210>  319
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  319

Xaa Asp Tyr Asp Asp Ser Xaa Asp Tyr 
1               5                   


<210>  320
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  320

Xaa Asp Tyr Asp Asp Ser Leu Xaa Tyr 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 17)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  321

Xaa Asp Tyr Asp Asp Ser Leu Asp Xaa 
1               5                   


<210>  322
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 

<400>  322

Gly Asp Tyr Gly Asp Ser Leu Asp Tyr 
1               5                   


<210>  323
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  323

Xaa Ser Gly Gly Lys 
1               5   


<210>  324
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  324

Trp Xaa Gly Gly Lys 
1               5   


<210>  325
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  325

Trp Ser Xaa Gly Lys 
1               5   


<210>  326
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  326

Trp Ser Gly Xaa Lys 
1               5   


<210>  327
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  327

Trp Ser Gly Gly Xaa 
1               5   


<210>  328
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  328

Xaa Xaa Gly Gly Lys 
1               5   


<210>  329
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  329

Xaa Ser Xaa Gly Lys 
1               5   


<210>  330
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  330

Xaa Ser Gly Xaa Lys 
1               5   


<210>  331
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  331

Xaa Ser Gly Gly Xaa 
1               5   


<210>  332
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  332

Trp Xaa Xaa Gly Lys 
1               5   


<210>  333
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  333

Trp Xaa Gly Xaa Lys 
1               5   


<210>  334
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3 library (Library 30)

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid

<400>  334

Trp Xaa Gly Gly Xaa 
1               5   


<210>  335
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/ AB5030 VH with G44C mutation

<400>  335

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  336
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/AB5030 VL with S100C mutation

<400>  336

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  337
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0192 Chain L VL CDR1

<400>  337

Arg Ala Ser Gln Gly Ile Ser Ser Trp Ala 
1               5                   10  


<210>  338
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0192 Chain H VH CDR2

<400>  338

Ser Ser Ser Ser Tyr 
1               5   


<210>  339
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0192 Chain H VH CDR3

<400>  339

Gly Ala Pro Met Ile Gly Ala Ala Ala Gly Trp Phe Asp Pro 
1               5                   10                  


<210>  340
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in AB0192 Chain S

<400>  340

Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe Gly Met His 
1               5                   10                  15      


Trp Val Arg 
            


<210>  341
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in AB0192 Chain S 

<400>  341

Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
1               5                   10      


<210>  342
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  found in AB0192 Chain S 

<400>  342

Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly Thr 
1               5                   10                  15      


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
        35                  40                  45              


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
    50                  55                  60  


