                         SEQUENCE LISTING

<110>  DRAGONFLY THERAPEUTICS, INC.
 
<120>  ANTIBODIES TARGETING CLEC12A AND USE THEREOF

<130>  14247-539-228

<140>  TBA
<141>  

<150>  US 63/020,806
<151>  2020-05-06

<160>  148   

<170>  PatentIn version 3.5

<210>  1
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16B8.C8 VH 

<400>  1

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Thr Pro Phe Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Ile Ser Lys Asn Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Pro Asn Asp Thr Ala Ile Tyr Phe Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16B8.C8 VL

<400>  2

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Ala Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1292 (VH-VL)

<400>  3

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16B8.C8 VH CDR2

<400>  4

Trp Ser Gly Gly Lys 
1               5   


<210>  5
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16B8.C8 VH CDR3

<400>  5

Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr 
1               5                   


<210>  6
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16B8.C8 VL CDR1

<400>  6

His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16B8.C8 VL CDR2

<400>  7

Glu Ala Ser Asn Leu His Thr 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  16B8.C8 VL CDR3

<400>  8

Gln Gln Ser His Ser Tyr Pro Leu Thr 
1               5                   


<210>  9
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1292/scFv-1301 VH 

<400>  9

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1292/scFv-1301 VL

<400>  10

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1292/scFv-1301 VH CDR1

<400>  11

Gly Phe Ser Leu Thr Asn Tyr 
1               5           


<210>  12
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1301 (VL-VH)

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1293/scFv-1302 VH 

<400>  13

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  14
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0192/AB0186 VH 

<400>  14

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  15
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1293 (VH-VL)

<400>  15

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  16
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1302 (VL-VH)

<400>  16

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  17
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 consensus -VL

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be Ala or Ile

<220>
<221>  misc_feature
<222>  (70)..(70)
<223>  Xaa can be Asp or Arg

<220>
<221>  misc_feature
<222>  (83)..(83)
<223>  Xaa can be Phe or Ile

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be Gln or Gly

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Xaa Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Xaa Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Xaa Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  18
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  18

Lys Ser Ser Gln Ser Leu Leu Trp Asn Val Asn Gln Asn Asn Tyr Leu 
1               5                   10                  15      


Val 
    


<210>  19
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1294 (VH-VL)

<400>  19

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  20
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1303 (VL-VH)

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  21
<211>  226
<212>  PRT
<213>  Artificial SequenceHomo sapiens

<220>
<223>  wild-type human IgG1 Fc sequence

<400>  21

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly 
225     


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VH 

<400>  22

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Ile Lys Leu Ser Cys Ala Ala Ser Ala Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Phe Ile His Trp Val Arg Gln Arg Pro Asp Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Asp Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Asp Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Ala Leu Trp Ser Arg Gly Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  23
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1295 (VH-VL)

<400>  23

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  24
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1304 (VL-VH)

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  25
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VL

<400>  25

Glu Val Leu Leu Thr Gln Ser Pro Ala Ile Ile Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Thr Cys Ser Ala Arg Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Ser Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Ile Trp Ile Tyr 
        35                  40                  45              


Gly Ile Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Tyr Phe Ser Phe Thr Ile Asn Asn Leu Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Gln Gln Arg Ser Tyr Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  26
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  26

Ala Phe Asn Ile Lys Asp Tyr 
1               5           


<210>  27
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1296 (VH-VL)

<400>  27

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  28
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1305 (VL-VH)

<400>  28

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0191/AB0185 VH 

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  30
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1297/scFv-1306 VL

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  31
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1297 (VH-VL)

<400>  31

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  32
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1306 (VL-VH)

<400>  32

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  33

Trp Ser Gly Gly Ser 
1               5   


<210>  34
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1298/scFv-1307 VL

<400>  34

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  35
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1298 (VH-VL)

<400>  35

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                

<210>  36
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1307 (VL-VH)

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                

<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15A10.G8 VH - CDR2

<400>  37

Asp Pro Glu Asn Asp Asp 
1               5       


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1299/scFv-1308 VL

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1299 (VH-VL)

<400>  39

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ile Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  40
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1308 (VL-VH)

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  41
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1300/scFv-1309 VH 

<400>  41

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  42
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1300/scFv-1309 VL

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  43
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1300 (VH-VL)

<400>  43

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  44
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1309 (VL-VH)

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  45
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1295/scFv-1304 VH 

<400>  45

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  46
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  46

Gln His Asn His Gly Ser Phe Leu Pro Tyr Thr 
1               5                   10      


<210>  47
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-1602 (VH-VL)

<400>  47

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  48
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv-2061 (VL-VH) 

<400>  48

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  49
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 consensus - VH

<220>
<221>  misc_feature
<222>  (71)..(71)
<223>  Xaa can be Val or Lys

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be Thr or Gln

<220>
<221>  misc_feature
<222>  (88)..(88)
<223>  Xaa can be Ala or Asn

<220>
<221>  misc_feature
<222>  (97)..(97)
<223>  Xaa can be Arg or Lys

<400>  49

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Xaa Ala Xaa Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Xaa Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  50
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  50

Leu Trp Ser Arg Gly Gly Tyr Phe Asp Tyr 
1               5                   10  


<210>  51
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0191 (VH-VL)

<400>  51

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  52
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0185 (VL-VH)

<400>  52

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  53

Ser Ala Arg Ser Ser Val Ser Tyr Met Ser 
1               5                   10  


<210>  54
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  54

Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr 
1               5                   10      


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  55

Gly Ile Ser Lys Leu Ala Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  56

Gln Gln Arg Ser Tyr Tyr Pro Phe Thr 
1               5                   


<210>  57
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VH 

<400>  57

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Asp Pro Ser Tyr Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Asn Tyr Tyr Gly Ser Gly Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  58
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  13E1.A4 VL

<400>  58

Ser Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Ala Ser Ile Ser Cys Arg Ser Ser Gln Gly Ile Val His Ile 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  59

Gly Phe Thr Phe Asn Ser Phe 
1               5           


<210>  60
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11.B7 VH 

<400>  60

Glu Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  61
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9F11.B7 VL

<400>  61

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Leu Lys Pro Gly Lys Ser Pro Arg Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Lys Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Asn Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Leu Gly Ile Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  62

Gly Phe Thr Phe Asn Ala Phe 
1               5           


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  63

Ser Ser Gly Ser Thr Ser 
1               5       


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  64

Gly Tyr Ser Phe Thr Ala Tyr 
1               5           


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  65

Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser 
1               5                   10      


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  66

Arg Ala Asn Ile Leu Val Ser 
1               5           


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  67

Leu Gln Phe Asp Ala Phe Pro Phe Thr 
1               5                   


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  68

Asp Pro Ser Tyr Gly Asp 
1               5       


<210>  69
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0191/AB0185 VL

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  70
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0192 (VH-VL)

<400>  70

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  71
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0186 (VL-VH)

<400>  71

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  72

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  73
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  73

Asp Asn Tyr Tyr Gly Ser Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  74
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0193 (VH-VL)

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  75
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0187 (VL-VH)

<400>  75

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  76
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0193/AB0187 VH 

<400>  76

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  77
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  77

Arg Ser Ser Gln Gly Ile Val His Ile Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  78

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  79
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  79

Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr 
1               5                   10      


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  80

Phe Gln Gly Ser His Val Pro Trp Thr 
1               5                   


<210>  81
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0194 (VH-VL)

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  82
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0188 (VL-VH)

<400>  82

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  83
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VH 

<400>  83

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Asn Val Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Met Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Arg Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Ser Tyr Tyr Tyr Asp Ser Ser Ser Arg Tyr Val Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  84
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 in AB0194/AB0188 VL

<400>  84

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  85
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12F8.H7 VL

<400>  85

Gly Ile Val Met Thr Gln Ala Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
            20                  25                  30          


Asp Gly Lys Thr Phe Leu Asn Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Ser Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Leu 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Thr His Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  86

Gly Phe Asn Ile Lys Asp Tyr 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  87

Gly Phe Ser Leu Thr Ser Phe 
1               5           


<210>  88
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  88

Asp Pro Glu Asn Gly Asp 
1               5       


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  89

Ser Tyr Phe Ala Met Asp Tyr 
1               5           


<210>  90
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  90

Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Phe Leu Asn 
1               5                   10                  15      


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  91

Leu Val Ser Lys Leu Asp Ser 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  92

Gly Ala Ser Ile Arg Glu Ser 
1               5           


<210>  93
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  93

Trp Gln Gly Thr His Phe Pro Tyr Thr 
1               5                   


<210>  94
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VH 

<400>  94

Glu Val Gln Leu Gln Glu Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Arg Thr Thr Gly Tyr Thr Phe Ser Thr Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly Arg Gly Pro Glu Trp Ile 
        35                  40                  45              


Gly Glu Leu Phe Pro Gly Asn Ser Asp Thr Thr Leu Asn Glu Lys Phe 
    50                  55                  60                  


Thr Gly Lys Ala Thr Phe Thr Ala Asp Ser Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Tyr Gly Ser Ser Leu Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  95
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  9E4.B7 VL

<400>  95

Gly Ile Val Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Gly Glu Asn Ile His Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  96

Gly Tyr Thr Phe Ser Thr Tyr 
1               5           


<210>  97
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  97

Phe Pro Gly Asn Ser Asp 
1               5       


<210>  98
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  98

Ser Gly Tyr Tyr Gly Ser Ser Leu Asp Tyr 
1               5                   10  


<210>  99
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  99

Arg Ala Gly Glu Asn Ile His Ser Tyr Leu Ala 
1               5                   10      


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  100

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  101

Gln His His Tyr Gly Thr Pro Arg Thr 
1               5                   


<210>  102
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  102

Trp Ser Gly Gly Asn 
1               5   


<210>  103
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 VL

<400>  103

Gly Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Leu Trp Asn 
            20                  25                  30          


Val Asn Gln Asn Asn Tyr Leu Val Trp Tyr Gln Gln Lys Gln Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Trp Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val His Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  104
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  20D6.H8 VH 

<400>  104

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Ser Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Thr Lys Asp Ile Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Val Thr Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  105
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  105

Gly Ala Ser Ile Arg Gln Ser 
1               5           


<210>  106
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  106

Lys Ser Ser Gln Ser Leu Leu Trp Asn Val Asn Gln Asn Asn Tyr Leu 
1               5                   10                  15      


Leu 
    


<210>  107
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  107

Thr His Phe Gly Met Asp Tyr 
1               5           


<210>  108
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VH 

<400>  108

Gln Val Gln Leu Arg Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Met Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Thr Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr His Phe Gly Met Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  109
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  23A5.H8 VL

<400>  109

Gly Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Leu Trp Ser 
            20                  25                  30          


Val Asn Gln Asn Asn Tyr Leu Leu Trp Tyr Gln Gln Lys Gln Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Gln Ser Trp Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser 
65                  70                  75                  80  


Ile Ser Asn Val His Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  110
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1294/scFv-1303 VH 

<400>  110

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  111

Lys Ser Ser Gln Ser Leu Leu Trp Ser Val Asn Gln Asn Asn Tyr Leu 
1               5                   10                  15      


Leu 
    


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 VH CDR3

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be Asp or Ser

<400>  112

Xaa Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr 
1               5                   10      


<210>  113
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30A9.E9 VH 

<400>  113

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Phe 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Ser Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Thr Ile Thr Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Thr Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ser Tyr Phe Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Ser 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  114
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30A9.E9 VL

<400>  114

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Val Thr Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Arg Cys Lys Ser Ser Gln Ser Leu Leu Trp Asn 
            20                  25                  30          


Val Asn Gln Asn Asn Tyr Leu Leu Trp Tyr Gln Gln Lys Gln Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Ile Arg Glu Ser Trp Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Asn Val His Val Glu Asp Leu Ala Val Tyr Tyr Cys Gln His 
                85                  90                  95      


Asn His Gly Ser Phe Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
            100                 105                 110         


Glu Ile Lys 
        115 


<210>  115
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 VH 

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be Ser or Ala

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa can be Asp or Ser

<400>  115

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Xaa Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Xaa Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  116
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 9F11.B7 VL

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be Gln or Lys

<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be Phe or Leu

<400>  116

Asp Ile Xaa Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Xaa Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  117
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be Ser or Ala

<400>  117

Gly Phe Thr Phe Asn Xaa Phe 
1               5           


<210>  118
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0195 (VH-VL)

<400>  118

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  119
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0189 (VL-VH)

<400>  119

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Asp Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  120
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0196 (VH-VL)

<400>  120

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Lys Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr Leu Ser Trp Phe 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile Tyr Arg Ala Asn 
            180                 185                 190         


Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe Thr Phe Gly Cys 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  121
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0190 (VL-VH)

<400>  121

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Tyr Asn Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Ile Leu Val Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln Phe Asp Ala Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ser Phe Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val Ala 
                165                 170                 175     


Phe Ile Ser Ser Gly Ser Thr Ser Ile Tyr Tyr Ala Asn Thr Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ser Gly Tyr Pro Thr Gly Gly Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  122
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1296/scFv-1305 VH 

<400>  122

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Lys Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Asn Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Asp Asp Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  123
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAbs Merus-CLL1 - VH

<400>  123

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Asn Tyr Gly Asp Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAbs Merus-CLL1 - VL

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  125
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAbs Genentech-h6E7 - VH

<400>  125

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Asn Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Glu Ile Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110     


<210>  126
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CLEC12A mAbs Genentech-h6E7 - VL

<400>  126

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asn Pro Tyr Asn Gly Ala Ala Phe Tyr Ser Gln Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Glu Arg Gly Ala Asp Leu Glu Gly Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  127
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  127

Tyr Tyr Tyr Asp Ser Ser Ser Arg Tyr Val Asp Val 
1               5                   10          


<210>  128
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/AB5030 VH 

<400>  128

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  129
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0305/AB5030 VL

<400>  129

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  130
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  130

Trp Val Gly Gly Ala 
1               5   


<210>  131
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  131

Gly Asp Tyr Gly Asp Thr Leu Asp Tyr 
1               5                   


<210>  132
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0305 (VH-VL)

<400>  132

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  133
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB5030 (VL-VH)

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  134
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0147/AB7410 VH 

<400>  134

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Leu Ser Gly Gly Trp Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  135
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in AB0147/AB7410 VL

<400>  135

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  136
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  136

Leu Ser Gly Gly Trp 
1               5   


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  137

Gly Asp Tyr Gly Asp Ala Leu Asp Tyr 
1               5                   


<210>  138
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB0147 (VH-VL)

<400>  138

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Leu Ser Gly Gly Trp Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


His Ala Ser Gln Asn Ile Asn Phe Trp Leu Ser Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Glu Ala Ser Asn Leu His 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Arg Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser His Ser Tyr Pro Leu Thr Phe Gly Cys Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys 
                


<210>  139
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AB7410 (VL-VH)

<400>  139

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    130                 135                 140                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr Gly 
145                 150                 155                 160 


Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile Gly 
                165                 170                 175     


Val Ile Leu Ser Gly Gly Trp Thr Asp Tyr Asn Pro Ser Leu Lys Ser 
            180                 185                 190         


Arg Val Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
        195                 200                 205             


Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Lys 
    210                 215                 220                 


Gly Asp Tyr Gly Asp Ala Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  140
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized 16B8.C8 in scFv-1602/scFv-2061 VL

<400>  140

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Arg Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  141
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant used to identify alternative sequence motifs without 
the DS site

<400>  141

Tyr Asp Tyr Asp Asp Ala Leu Asp Tyr 
1               5                   


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant used to identify alternative sequence motifs without 
the DS site

<400>  142

Tyr Asp Tyr Asp Asp Ile Leu Asp Tyr 
1               5                   


<210>  143
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant used to identify alternative sequence motifs without 
the DS site

<400>  143

Tyr Asp Tyr Asp Asp Leu Leu Asp Tyr 
1               5                   


<210>  144
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of binder to hCLEC12A

<400>  144

Tyr Asp Tyr Asp Asp Val Leu Asp Tyr 
1               5                   


<210>  145
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of non-binder to hCLEC12A

<400>  145

Tyr Asp Tyr Asp Asp Thr Leu Asp Tyr 
1               5                   


<210>  146
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of non-binder to hCLEC12A

<400>  146

Tyr Asp Tyr Asp Glu Ser Leu Asp Tyr 
1               5                   


<210>  147
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC12A VH

<400>  147

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Leu His Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Val Gly Gly Ala Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Gln Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asp Tyr Gly Asp Thr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  148
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CLEC12A VL

<400>  148

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Phe Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Glu Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser His Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


