                         SEQUENCE LISTING

<110>  Conagen, Inc.
 
<120>  PRODUCTION OF NMN AND ITS DERIVATIVES VIA MICROBIAL PROCESSES

<130>  C1497.70055WO00

<140>  Not yet assigned
<141>  Concurrently herewith

<150>  US 63/020,052
<151>  2020-05-05

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  561
<212>  PRT
<213>  Chromobacterium violaceum


<400>  1

Met Thr Ala Pro Lys Ala Ala Gln Asp Lys Asn Gln Leu Val Pro Phe 
1               5                   10                  15      


Asn Leu Ala Asp Phe Tyr Lys Thr Gly His Pro Ala Met Tyr Pro Arg 
            20                  25                  30          


Glu Thr Thr Arg Leu Val Ala Asn Phe Thr Pro Arg Ser Ala Lys Tyr 
        35                  40                  45              


Ala Gln Val Leu Pro Gln Leu Phe Asp Asp Lys Val Val Trp Phe Gly 
    50                  55                  60                  


Leu Gln Gly Phe Ile Gln Glu Tyr Leu Ile Asp Leu Phe Asn Arg Glu 
65                  70                  75                  80  


Phe Phe Gln Arg Pro Lys Ala Asp Ala Val Arg Arg Tyr Gln Arg Arg 
                85                  90                  95      


Met Asp Thr Ala Leu Gly Ala Gly Ala Val Asp Gly Gly Arg Leu Glu 
            100                 105                 110         


Ala Leu His Asp Leu Gly His Leu Pro Leu Glu Ile Arg Ser Leu Pro 
        115                 120                 125             


Glu Gly Ala Arg Val Asp Ile Lys Val Pro Pro Val Thr Phe Ser Asn 
    130                 135                 140                 


Thr His Pro Asp Phe Pro Trp Val Ala Thr Tyr Phe Glu Thr Leu Phe 
145                 150                 155                 160 


Ser Cys Glu Ser Trp Lys Pro Ser Thr Val Ala Thr Ile Ala Phe Glu 
                165                 170                 175     


Phe Arg Lys Leu Leu Ser Tyr Phe Ala Ala Leu Thr Gly Ala Pro Gln 
            180                 185                 190         


Asp Phe Val Ala Trp Gln Gly His Asp Phe Ser Met Arg Gly Met Ser 
        195                 200                 205             


Gly Val His Asp Ala Met Arg Cys Gly Ala Gly His Leu Leu Ser Phe 
    210                 215                 220                 


Thr Gly Thr Asp Thr Ile Pro Ala Leu Asp Tyr Leu Glu Asp His Tyr 
225                 230                 235                 240 


Gly Ala Asp Ala Glu Arg Glu Leu Val Gly Gly Ser Ile Pro Ala Ser 
                245                 250                 255     


Glu His Ser Val Met Ala Leu Arg Ile Leu Leu Thr Gln Gln Arg Leu 
            260                 265                 270         


Ala Arg Met Pro Ala His Gln Gly Leu Asp Asp Lys Ala Leu Arg Arg 
        275                 280                 285             


Leu Ala Glu Arg Glu Val Val Arg Glu Phe Val Thr Arg Asp Tyr Pro 
    290                 295                 300                 


Ala Gly Met Val Ser Ile Val Ser Asp Thr Phe Asp Phe Trp Asn Val 
305                 310                 315                 320 


Leu Thr Val Ile Ala Arg Glu Leu Lys Asp Asp Ile Gln Ala Arg Arg 
                325                 330                 335     


Pro Asp Ala Leu Gly Asn Ala Lys Val Val Phe Arg Pro Asp Ser Gly 
            340                 345                 350         


Asp Pro Val Arg Ile Leu Ala Gly Tyr Arg Asp Asp Glu Leu Gln Phe 
        355                 360                 365             


Asp Asp Ala Gly Asn Cys Thr Ala Arg Asp Asp Gly Arg Pro Val Ser 
    370                 375                 380                 


Ala Ala Glu Arg Lys Gly Ala Val Glu Cys Leu Trp Asp Ile Phe Gly 
385                 390                 395                 400 


Gly Thr Val Thr Glu Arg Gly Tyr Arg Val Leu Asp Ser His Val Gly 
                405                 410                 415     


Leu Ile Tyr Gly Asp Ser Ile Thr Leu Pro Arg Ala Arg Asp Ile Leu 
            420                 425                 430         


Leu Arg Leu Ala Glu Lys Gly Tyr Ala Ser Cys Asn Val Val Phe Gly 
        435                 440                 445             


Ile Gly Ser Phe Val Tyr Gly Met Asn Ser Arg Asp Thr Phe Gly Tyr 
    450                 455                 460                 


Ala Leu Lys Ala Val Tyr Ala Glu Val Ala Gly Glu Ala Val Asp Ile 
465                 470                 475                 480 


Tyr Lys Asp Pro Ala Thr Asp Asp Gly Thr Lys Lys Ser Ala Arg Gly 
                485                 490                 495     


Leu Leu Arg Val Glu Glu Glu Asn Gly Arg Tyr Ala Leu Tyr Gln Gln 
            500                 505                 510         


Gln Thr Pro Ala Glu Ala Glu Gly Gly Ala Leu Arg Pro Val Phe Arg 
        515                 520                 525             


Asp Gly Glu Leu Leu Val Lys Gln Thr Leu Ala Glu Ile Arg Gln Arg 
    530                 535                 540                 


Leu Gln Ala Ser Trp Thr Cys Pro Glu Ala Gly Ser Ile Val Trp Asn 
545                 550                 555                 560 


Ala 
    


<210>  2
<211>  469
<212>  PRT
<213>  Stenotrophomonas maltophilia


<400>  2

Met His Tyr Leu Asp Asn Leu Leu Leu Asn Thr Asp Ser Tyr Lys Ala 
1               5                   10                  15      


Ser His Trp Leu Gln Tyr Pro Pro Gly Thr Asp Ala Thr Phe Phe Tyr 
            20                  25                  30          


Val Glu Ser Arg Gly Gly Leu His Asp Arg Thr Val Phe Phe Gly Leu 
        35                  40                  45              


Gln Ala Ile Leu Lys Asp Ala Leu Ala Arg Pro Val Thr His Ala Asp 
    50                  55                  60                  


Ile Asp Asp Ala Ala Ala Val Phe Ala Ala His Gly Glu Pro Phe Asn 
65                  70                  75                  80  


Glu Ala Gly Trp Arg Asp Ile Val Asp Arg Leu Gly Gly His Leu Pro 
                85                  90                  95      


Val Arg Ile Arg Ala Val Pro Glu Gly Ser Val Val Pro Thr His Gln 
            100                 105                 110         


Ala Leu Met Thr Ile Glu Ser Thr Asp Pro Ala Ala Phe Trp Val Pro 
        115                 120                 125             


Ser Tyr Leu Glu Thr Leu Leu Leu Arg Val Trp Tyr Pro Val Thr Val 
    130                 135                 140                 


Ala Thr Ile Ser Trp His Ala Arg Gln Thr Ile Ala Ala Phe Leu Gln 
145                 150                 155                 160 


Gln Thr Ser Asp Asp Pro Gln Gly Gln Leu Pro Phe Lys Leu His Asp 
                165                 170                 175     


Phe Gly Ala Arg Gly Val Ser Ser Leu Glu Ser Ala Ala Leu Gly Gly 
            180                 185                 190         


Ala Ala His Leu Val Asn Phe Leu Gly Thr Asp Thr Val Ser Ala Leu 
        195                 200                 205             


Cys Leu Ala Arg Ala His Tyr His Ala Pro Met Ala Gly Tyr Ser Ile 
    210                 215                 220                 


Pro Ala Ala Glu His Ser Thr Ile Thr Ser Trp Gly Arg Glu Arg Glu 
225                 230                 235                 240 


Val Asp Ala Tyr Arg Asn Met Leu Arg Gln Phe Gly Lys Pro Gly Ser 
                245                 250                 255     


Ile Val Ala Val Val Ser Asp Ser Tyr Asp Ile Tyr Arg Ala Ile Ser 
            260                 265                 270         


Glu His Trp Gly Thr Thr Leu Arg Asp Asp Val Ile Ala Ser Gly Ala 
        275                 280                 285             


Thr Leu Val Ile Arg Pro Asp Ser Gly Asp Pro Val Glu Val Val Ala 
    290                 295                 300                 


Glu Ser Leu Arg Arg Leu Asp Glu Ala Phe Gly His Ala Ile Asn Gly 
305                 310                 315                 320 


Lys Gly Tyr Arg Val Leu Asn His Val Arg Val Ile Gln Gly Asp Gly 
                325                 330                 335     


Ile Asn Pro Asp Thr Ile Arg Ala Ile Leu Gln Arg Ile Thr Asp Asp 
            340                 345                 350         


Gly Tyr Ala Ala Asp Asn Val Ala Phe Gly Met Gly Gly Ala Leu Leu 
        355                 360                 365             


Gln Arg Leu Asp Arg Asp Thr Gln Lys Phe Ala Leu Lys Cys Ser Ala 
    370                 375                 380                 


Ala Arg Val Glu Gly Glu Trp Ile Asp Val Tyr Lys Asp Pro Val Thr 
385                 390                 395                 400 


Asp Ala Gly Lys Ala Ser Lys Arg Gly Arg Met Arg Leu Leu Arg Arg 
                405                 410                 415     


Leu Asp Asp Gly Ser Leu His Thr Val Pro Leu Pro Ala Asn Gly Asp 
            420                 425                 430         


Asp Thr Leu Pro Asp Gly Phe Glu Asp Ala Met Val Thr Val Trp Glu 
        435                 440                 445             


Asn Gly His Leu Leu Tyr Asp Gln Arg Leu Asp Asp Ile Arg Thr Arg 
    450                 455                 460                 


Ala Ala Val Gly His 
465                 


<210>  3
<211>  325
<212>  PRT
<213>  Unknown

<220>
<223>  Codon-optimized PRPP synthase variant, CYL77_RS04805 - prsA (PRS)

<400>  3

Met Thr Ala His Trp Lys Gln Asn Gln Lys Asn Leu Met Leu Phe Ser 
1               5                   10                  15      


Gly Arg Ala His Pro Glu Leu Ala Glu Ala Val Ala Lys Glu Leu Asp 
            20                  25                  30          


Val Asn Val Thr Pro Met Thr Ala Arg Asp Phe Ala Asn Gly Glu Ile 
        35                  40                  45              


Tyr Val Arg Phe Glu Glu Ser Val Arg Gly Ser Asp Cys Phe Val Leu 
    50                  55                  60                  


Gln Ser His Thr Gln Pro Leu Asn Lys Trp Leu Met Glu Gln Leu Leu 
65                  70                  75                  80  


Met Ile Asp Ala Leu Lys Arg Gly Ser Ala Lys Arg Ile Thr Ala Ile 
                85                  90                  95      


Leu Pro Phe Tyr Pro Tyr Ala Arg Gln Asp Lys Lys His Arg Gly Arg 
            100                 105                 110         


Glu Pro Ile Ser Ala Arg Leu Ile Ala Asp Leu Met Leu Thr Ala Gly 
        115                 120                 125             


Ala Asp Arg Ile Val Ser Val Asp Leu His Thr Asp Gln Ile Gln Gly 
    130                 135                 140                 


Phe Phe Asp Gly Pro Val Asp His Met His Ala Met Pro Ile Leu Thr 
145                 150                 155                 160 


Asp His Ile Lys Glu Asn Tyr Asn Leu Asp Asn Ile Cys Val Val Ser 
                165                 170                 175     


Pro Asp Ala Gly Arg Val Lys Val Ala Glu Lys Trp Ala Asn Thr Leu 
            180                 185                 190         


Gly Asp Ala Pro Met Ala Phe Val His Lys Thr Arg Ser Thr Glu Val 
        195                 200                 205             


Ala Asn Gln Val Val Ala Asn Arg Val Val Gly Asp Val Asp Gly Lys 
    210                 215                 220                 


Asp Cys Val Leu Leu Asp Asp Met Ile Asp Thr Gly Gly Thr Ile Ala 
225                 230                 235                 240 


Gly Ala Val Gly Val Leu Lys Lys Ala Gly Ala Lys Ser Val Val Ile 
                245                 250                 255     


Ala Cys Thr His Gly Val Phe Ser Asp Pro Ala Arg Glu Arg Leu Ser 
            260                 265                 270         


Ala Cys Gly Ala Glu Glu Val Ile Thr Thr Asp Thr Leu Pro Gln Ser 
        275                 280                 285             


Thr Glu Gly Trp Ser Asn Leu Thr Val Leu Ser Ile Ala Pro Leu Leu 
    290                 295                 300                 


Ala Arg Thr Ile Asn Glu Ile Phe Glu Asn Gly Ser Val Thr Thr Leu 
305                 310                 315                 320 


Phe Glu Gly Glu Ala 
                325 


<210>  4
<211>  325
<212>  PRT
<213>  Unknown

<220>
<223>  Feedback resistant PRPP synthase mutant, prsA L136I (PRS L136I)

<400>  4

Met Thr Ala His Trp Lys Gln Asn Gln Lys Asn Leu Met Leu Phe Ser 
1               5                   10                  15      


Gly Arg Ala His Pro Glu Leu Ala Glu Ala Val Ala Lys Glu Leu Asp 
            20                  25                  30          


Val Asn Val Thr Pro Met Thr Ala Arg Asp Phe Ala Asn Gly Glu Ile 
        35                  40                  45              


Tyr Val Arg Phe Glu Glu Ser Val Arg Gly Ser Asp Cys Phe Val Leu 
    50                  55                  60                  


Gln Ser His Thr Gln Pro Leu Asn Lys Trp Leu Met Glu Gln Leu Leu 
65                  70                  75                  80  


Met Ile Asp Ala Leu Lys Arg Gly Ser Ala Lys Arg Ile Thr Ala Ile 
                85                  90                  95      


Leu Pro Phe Tyr Pro Tyr Ala Arg Gln Asp Lys Lys His Arg Gly Arg 
            100                 105                 110         


Glu Pro Ile Ser Ala Arg Leu Ile Ala Asp Leu Met Leu Thr Ala Gly 
        115                 120                 125             


Ala Asp Arg Ile Val Ser Val Asp Ile His Thr Asp Gln Ile Gln Gly 
    130                 135                 140                 


Phe Phe Asp Gly Pro Val Asp His Met His Ala Met Pro Ile Leu Thr 
145                 150                 155                 160 


Asp His Ile Lys Glu Asn Tyr Asn Leu Asp Asn Ile Cys Val Val Ser 
                165                 170                 175     


Pro Asp Ala Gly Arg Val Lys Val Ala Glu Lys Trp Ala Asn Thr Leu 
            180                 185                 190         


Gly Asp Ala Pro Met Ala Phe Val His Lys Thr Arg Ser Thr Glu Val 
        195                 200                 205             


Ala Asn Gln Val Val Ala Asn Arg Val Val Gly Asp Val Asp Gly Lys 
    210                 215                 220                 


Asp Cys Val Leu Leu Asp Asp Met Ile Asp Thr Gly Gly Thr Ile Ala 
225                 230                 235                 240 


Gly Ala Val Gly Val Leu Lys Lys Ala Gly Ala Lys Ser Val Val Ile 
                245                 250                 255     


Ala Cys Thr His Gly Val Phe Ser Asp Pro Ala Arg Glu Arg Leu Ser 
            260                 265                 270         


Ala Cys Gly Ala Glu Glu Val Ile Thr Thr Asp Thr Leu Pro Gln Ser 
        275                 280                 285             


Thr Glu Gly Trp Ser Asn Leu Thr Val Leu Ser Ile Ala Pro Leu Leu 
    290                 295                 300                 


Ala Arg Thr Ile Asn Glu Ile Phe Glu Asn Gly Ser Val Thr Thr Leu 
305                 310                 315                 320 


Phe Glu Gly Glu Ala 
                325 


<210>  5
<211>  561
<212>  DNA
<213>  Unknown

<220>
<223>  Nicotinamidase pncA (CGL_RS12350, ncgl2401, cgl2487)

<400>  5
atggcacgcg cactcattct ggttgatgtt caaaaagact tctgccccgg tggcagccta       60

gccaccgaac gaggcgatga agtggcggga aaaatcggtg cctatcagct gtcccacggc      120

tcagagtacg acgtcgttgt ggcgacccaa gattggcaca tcgatccagg cgagcacttt      180

tcagaaaccc cagactttaa aaactcctgg ccaatccact gcgtcgcgga ttccgatggt      240

gccgccatgc atgaccgcat caacaccgat tcaatcgatg agttcttccg caaaggccat      300

tacaccgcgg cgtattccgg gttcgaggga actgcagtca gtgaagaact cctcatgtct      360

ccatggctga agaacaaggg agtcactgat gtagacatcg tagggatcgc tacggatcac      420

tgcgttcgag ccacagcact tgatgctctc aaggagggct tcaacgtctc cattttgacg      480

tcgatgtgtt ctgcggtgga tttccatgcg ggagaccacg ctttggagga actacatgaa      540

gccggggcga ttctgattta a                                                561


<210>  6
<211>  186
<212>  PRT
<213>  Unknown

<220>
<223>  Nicotinamidase pncA (CGL_RS12350, ncgl2401, cgl2487)

<400>  6

Met Ala Arg Ala Leu Ile Leu Val Asp Val Gln Lys Asp Phe Cys Pro 
1               5                   10                  15      


Gly Gly Ser Leu Ala Thr Glu Arg Gly Asp Glu Val Ala Gly Lys Ile 
            20                  25                  30          


Gly Ala Tyr Gln Leu Ser His Gly Ser Glu Tyr Asp Val Val Val Ala 
        35                  40                  45              


Thr Gln Asp Trp His Ile Asp Pro Gly Glu His Phe Ser Glu Thr Pro 
    50                  55                  60                  


Asp Phe Lys Asn Ser Trp Pro Ile His Cys Val Ala Asp Ser Asp Gly 
65                  70                  75                  80  


Ala Ala Met His Asp Arg Ile Asn Thr Asp Ser Ile Asp Glu Phe Phe 
                85                  90                  95      


Arg Lys Gly His Tyr Thr Ala Ala Tyr Ser Gly Phe Glu Gly Thr Ala 
            100                 105                 110         


Val Ser Glu Glu Leu Leu Met Ser Pro Trp Leu Lys Asn Lys Gly Val 
        115                 120                 125             


Thr Asp Val Asp Ile Val Gly Ile Ala Thr Asp His Cys Val Arg Ala 
    130                 135                 140                 


Thr Ala Leu Asp Ala Leu Lys Glu Gly Phe Asn Val Ser Ile Leu Thr 
145                 150                 155                 160 


Ser Met Cys Ser Ala Val Asp Phe His Ala Gly Asp His Ala Leu Glu 
                165                 170                 175     


Glu Leu His Glu Ala Gly Ala Ile Leu Ile 
            180                 185     


<210>  7
<211>  519
<212>  DNA
<213>  Unknown

<220>
<223>  Nicotinamide-nucleotide amidohydrolase pncC (CGL_RS09770, 
       ncgl1888, cgl1963)

<400>  7
atgtcggaga atctggcggg gcgagtggtg gagctgttga aatcgcgcgg tgaaacgctg       60

gcgttttgtg aatccctcac cgccggcctt gccagtgcga cgatcgcaga gatccccggc      120

gcctcagtgg tacttaaagg cgggctggtc acctatgcca ccgagcttaa ggttgcgctt      180

gccggtgtgc cgcaggagct tatcgacgcg cacggcgttg tttccccgca gtgcgcccgt      240

gcgatggcaa cgggggccgc acacagatgc caggcagatt gggcggtttc gctcacgggc      300

gttgctggcc ccagcaaaca agatggtcat ccggtggggg aagtgtggat cggagtggct      360

ggtcctgcgc attttggggc gtcgggaaca attgacgcgt atcgtgcgtt tgaaagtgaa      420

caacaggtaa tattggctga attgggacgg catcatatta gagagtctgc tgtgcagcaa      480

agctttcgcc tgctgattga ccatattgag tcgcagtga                             519


<210>  8
<211>  172
<212>  PRT
<213>  Unknown

<220>
<223>  Nicotinamide-nucleotide amidohydrolase pncC (CGL_RS09770, 
       ncgl1888, cgl1963)

<400>  8

Met Ser Glu Asn Leu Ala Gly Arg Val Val Glu Leu Leu Lys Ser Arg 
1               5                   10                  15      


Gly Glu Thr Leu Ala Phe Cys Glu Ser Leu Thr Ala Gly Leu Ala Ser 
            20                  25                  30          


Ala Thr Ile Ala Glu Ile Pro Gly Ala Ser Val Val Leu Lys Gly Gly 
        35                  40                  45              


Leu Val Thr Tyr Ala Thr Glu Leu Lys Val Ala Leu Ala Gly Val Pro 
    50                  55                  60                  


Gln Glu Leu Ile Asp Ala His Gly Val Val Ser Pro Gln Cys Ala Arg 
65                  70                  75                  80  


Ala Met Ala Thr Gly Ala Ala His Arg Cys Gln Ala Asp Trp Ala Val 
                85                  90                  95      


Ser Leu Thr Gly Val Ala Gly Pro Ser Lys Gln Asp Gly His Pro Val 
            100                 105                 110         


Gly Glu Val Trp Ile Gly Val Ala Gly Pro Ala His Phe Gly Ala Ser 
        115                 120                 125             


Gly Thr Ile Asp Ala Tyr Arg Ala Phe Glu Ser Glu Gln Gln Val Ile 
    130                 135                 140                 


Leu Ala Glu Leu Gly Arg His His Ile Arg Glu Ser Ala Val Gln Gln 
145                 150                 155                 160 


Ser Phe Arg Leu Leu Ile Asp His Ile Glu Ser Gln 
                165                 170         


<210>  9
<211>  1077
<212>  DNA
<213>  Unknown

<220>
<223>  Restriction modification system; RM= cgl1777 (CYL77_RS08985)

<400>  9
atgaagccca ccgttaatgt tgtgttcaat gcgcatcacc ccaaagatac gcagccgttg       60

gataagttct tcgataaaga acttaaagac acacatcatc tcgatataac ggtgggttat      120

atcagtgaga aatcactaca atatttgctt cttattgcag gcactcaccc cgacctcacc      180

atcacactca cctgtggaat gcacgctcgt gaaggcatga ctgctgccca actgcatcat      240

gcgcgagtgc tccatgacta cttaagcgac catgatcgag gcggggtgtt cgttattccc      300

cgattgcgtt atcacggcaa aatctatctt ttccacaaga accagcacac agatcctatt      360

gcttatatcg gtagcgctaa cctctcagcc atcgttcctg ggtacacctc tacattcgag      420

accggcgtca tcttagaccc cgcacctgaa gatctcgtgc ttcatctcaa ccgtgatgtc      480

gtacccctat gtgtccccat tgacaccgcg catgtcccca tcattaaaga tcaagaatcc      540

ccgatgaagc acgtcgctga agcaacagct gtgtccacct ctgatgttgt tgccatcatg      600

tccagcccat ttacttatag ttttgacctt aaactcaaag ccactgccag cagcaacctc      660

aatgctcata actcaggcgg tggcgcgcgc aaacagaaaa acggtagctt ccttgcacgc      720

aattggtatg agggcgaaat cattgtcggt gtcgagacaa caagactccc aggttaccca      780

caaaacaaat ccgaattcac tgcggtcact gatgacggct ggtcatttgt ttgcaaaatc      840

agcggaggaa acggaaagaa cctacgcagc aaaggtgacc tgtccatcct cggtacgtgg      900

ttaaagtctc gattcattga acaaggtgcc ctggaatacg gcgaggatgc cacccaagaa      960

aacatcgacc gttttgggag aacacatatg accatgcgct atcacccaga tttcgatgtg     1020

tggtcattcg atctcagcca aaccccgaag ccttcgacac agattgggca ggattaa        1077


<210>  10
<211>  358
<212>  PRT
<213>  Unknown

<220>
<223>  Restriction modification system; RM= cgl1777 (CYL77_RS08985)

<400>  10

Met Lys Pro Thr Val Asn Val Val Phe Asn Ala His His Pro Lys Asp 
1               5                   10                  15      


Thr Gln Pro Leu Asp Lys Phe Phe Asp Lys Glu Leu Lys Asp Thr His 
            20                  25                  30          


His Leu Asp Ile Thr Val Gly Tyr Ile Ser Glu Lys Ser Leu Gln Tyr 
        35                  40                  45              


Leu Leu Leu Ile Ala Gly Thr His Pro Asp Leu Thr Ile Thr Leu Thr 
    50                  55                  60                  


Cys Gly Met His Ala Arg Glu Gly Met Thr Ala Ala Gln Leu His His 
65                  70                  75                  80  


Ala Arg Val Leu His Asp Tyr Leu Ser Asp His Asp Arg Gly Gly Val 
                85                  90                  95      


Phe Val Ile Pro Arg Leu Arg Tyr His Gly Lys Ile Tyr Leu Phe His 
            100                 105                 110         


Lys Asn Gln His Thr Asp Pro Ile Ala Tyr Ile Gly Ser Ala Asn Leu 
        115                 120                 125             


Ser Ala Ile Val Pro Gly Tyr Thr Ser Thr Phe Glu Thr Gly Val Ile 
    130                 135                 140                 


Leu Asp Pro Ala Pro Glu Asp Leu Val Leu His Leu Asn Arg Asp Val 
145                 150                 155                 160 


Val Pro Leu Cys Val Pro Ile Asp Thr Ala His Val Pro Ile Ile Lys 
                165                 170                 175     


Asp Gln Glu Ser Pro Met Lys His Val Ala Glu Ala Thr Ala Val Ser 
            180                 185                 190         


Thr Ser Asp Val Val Ala Ile Met Ser Ser Pro Phe Thr Tyr Ser Phe 
        195                 200                 205             


Asp Leu Lys Leu Lys Ala Thr Ala Ser Ser Asn Leu Asn Ala His Asn 
    210                 215                 220                 


Ser Gly Gly Gly Ala Arg Lys Gln Lys Asn Gly Ser Phe Leu Ala Arg 
225                 230                 235                 240 


Asn Trp Tyr Glu Gly Glu Ile Ile Val Gly Val Glu Thr Thr Arg Leu 
                245                 250                 255     


Pro Gly Tyr Pro Gln Asn Lys Ser Glu Phe Thr Ala Val Thr Asp Asp 
            260                 265                 270         


Gly Trp Ser Phe Val Cys Lys Ile Ser Gly Gly Asn Gly Lys Asn Leu 
        275                 280                 285             


Arg Ser Lys Gly Asp Leu Ser Ile Leu Gly Thr Trp Leu Lys Ser Arg 
    290                 295                 300                 


Phe Ile Glu Gln Gly Ala Leu Glu Tyr Gly Glu Asp Ala Thr Gln Glu 
305                 310                 315                 320 


Asn Ile Asp Arg Phe Gly Arg Thr His Met Thr Met Arg Tyr His Pro 
                325                 330                 335     


Asp Phe Asp Val Trp Ser Phe Asp Leu Ser Gln Thr Pro Lys Pro Ser 
            340                 345                 350         


Thr Gln Ile Gly Gln Asp 
        355             


<210>  11
<211>  1886
<212>  DNA
<213>  Unknown

<220>
<223>  Restriction modification system; RM= cgl1778 (CYL77_RS08990)

<400>  11
rtcacctcaa taactacatc acgagcttga gtgataacgc tgatctccgt gaaaaagtca       60

ccgcaaccgt agacgctttc cgccataccg tcatggatga cttcgactac atcagtgatc      120

aacaagtcct gctttatggc gatgtccaaa gcggtaaaac ctcacacatg ctgggaatta      180

tcgcagattg cctcgacagt acgtttcaca ccattgttat tctgacctcg cctaacacac      240

ggctcgtgca acaaacatac gaccgtgttg cccaagcatt tccagatact ttggtgtgcg      300

accgtgacgg atacaatgat ttccgtgcga atcaaaagag cctcaccccg cgaaaatcta      360

tcgtagtcgt cggaaaaata cctgcagttc ttggtaattg gttacgcgtc tttaacgaca      420

gtggcgcact ttctggacac cctgtactca ttattgatga cgaagcagat gcgacaagtc      480

tcaacaccaa agtaaatcag tctgatgttt cgaccattaa ccaccagctc actagcataa      540

gagaccttgc cacaggatgc atctaccttc aggtcacagg tacacctcaa gcggtgcttc      600

ttcaaagcga cgatagcaac tgggcagcgg aacatgtgct tcacttcgca cctggtgaga      660

gctacatcgg tggtcaactt ttcttttctg agctcaacaa cccttatcta cgacttttcg      720

ctaataccca atttgacgag gattctcgct tcagcgacgc catttacacc tatctcttaa      780

ccgcagcact gttcaaactt cgcggtgaaa gcttgtgtac catgctcatt caccccagcc      840

acactgcatc cagtcataga gacttcgcgc aagaagcccg cctccaactc actttcgcct      900

tcgagcgatt ctatgaacca atgattcagc acaatttcca acgtgcttat gaacagctcg      960

cacaaactga cagcaacctg ccacccttga gaaaaattct taacattctt ggtggcatgg     1020

aagatgactt ctccatccac atcgtcaata gcgacaaccc gactgttgag gaagattggg     1080

ctgatggtta taacattatt gtcggtggca actcgcttgg gcgcggttta acattcaaca     1140

acttgcaaac cgttttctac gtgcgcgaat ccaagcgacc acaagcagac accctgtggc     1200

agcacgcccg catgtttggc tacaaacgcc acaaagacac catgcgtgtg ttcatgccgg     1260

ccactattgc tcaaaccttc caagaggtct atctcggcaa cgaagctatt aaaaatcagc     1320

tcgatcatgg cacgcatatc aacgacattc gggtcatttt aggtgatggc gtcgcaccta     1380

ctcgtgccaa tgttctcgac aaacgcaaag ttggaaacct cagcggtggc gtcaactact     1440

ttgccgctga tcctagaatc aagaatgtcg aagcactcga caaaaaactc ttggcctact     1500

tagacaagca cggtgaggac tccaccatcg gtatgcgcgc gataatcacc attctcaacg     1560

cctttactgt agaccccaac gatctcgacc tcgcgacctt caaggctgcg ctccttgact     1620

ttgaacgcaa ccaacctcat ctcacagcac gtatggtgct gcgaacaaac cgcaaagtca     1680

atcagggtac aggcgccctg ctctccccta ctgatcaagc tctcagccgt gcagaagtcg     1740

cacacccatt attgatccta taccgcattg aaggtgttaa cgatgctgct gcgcaacgag     1800

gtgaacctac gtggtcaagc gaccctatct gggtgcctaa tattaaactc cctggtcaac     1860

gtcaattctg gtgcgtagac ggctaa                                          1886


<210>  12
<211>  632
<212>  PRT
<213>  Unknown

<220>
<223>  Restriction modification system; RM= cgl1778 (CYL77_RS08990)

<400>  12

Met Ser His His Thr His Leu Asn Asn Tyr Ile Thr Ser Leu Ser Asp 
1               5                   10                  15      


Asn Ala Asp Leu Arg Glu Lys Val Thr Ala Thr Val Asp Ala Phe Arg 
            20                  25                  30          


His Thr Val Met Asp Asp Phe Asp Tyr Ile Ser Asp Gln Gln Val Leu 
        35                  40                  45              


Leu Tyr Gly Asp Val Gln Ser Gly Lys Thr Ser His Met Leu Gly Ile 
    50                  55                  60                  


Ile Ala Asp Cys Leu Asp Ser Thr Phe His Thr Ile Val Ile Leu Thr 
65                  70                  75                  80  


Ser Pro Asn Thr Arg Leu Val Gln Gln Thr Tyr Asp Arg Val Ala Gln 
                85                  90                  95      


Ala Phe Pro Asp Thr Leu Val Cys Asp Arg Asp Gly Tyr Asn Asp Phe 
            100                 105                 110         


Arg Ala Asn Gln Lys Ser Leu Thr Pro Arg Lys Ser Ile Val Val Val 
        115                 120                 125             


Gly Lys Ile Pro Ala Val Leu Gly Asn Trp Leu Arg Val Phe Asn Asp 
    130                 135                 140                 


Ser Gly Ala Leu Ser Gly His Pro Val Leu Ile Ile Asp Asp Glu Ala 
145                 150                 155                 160 


Asp Ala Thr Ser Leu Asn Thr Lys Val Asn Gln Ser Asp Val Ser Thr 
                165                 170                 175     


Ile Asn His Gln Leu Thr Ser Ile Arg Asp Leu Ala Thr Gly Cys Ile 
            180                 185                 190         


Tyr Leu Gln Val Thr Gly Thr Pro Gln Ala Val Leu Leu Gln Ser Asp 
        195                 200                 205             


Asp Ser Asn Trp Ala Ala Glu His Val Leu His Phe Ala Pro Gly Glu 
    210                 215                 220                 


Ser Tyr Ile Gly Gly Gln Leu Phe Phe Ser Glu Leu Asn Asn Pro Tyr 
225                 230                 235                 240 


Leu Arg Leu Phe Ala Asn Thr Gln Phe Asp Glu Asp Ser Arg Phe Ser 
                245                 250                 255     


Asp Ala Ile Tyr Thr Tyr Leu Leu Thr Ala Ala Leu Phe Lys Leu Arg 
            260                 265                 270         


Gly Glu Ser Leu Cys Thr Met Leu Ile His Pro Ser His Thr Ala Ser 
        275                 280                 285             


Ser His Arg Asp Phe Ala Gln Glu Ala Arg Leu Gln Leu Thr Phe Ala 
    290                 295                 300                 


Phe Glu Arg Phe Tyr Glu Pro Met Ile Gln His Asn Phe Gln Arg Ala 
305                 310                 315                 320 


Tyr Glu Gln Leu Ala Gln Thr Asp Ser Asn Leu Pro Pro Leu Arg Lys 
                325                 330                 335     


Ile Leu Asn Ile Leu Gly Gly Met Glu Asp Asp Phe Ser Ile His Ile 
            340                 345                 350         


Val Asn Ser Asp Asn Pro Thr Val Glu Glu Asp Trp Ala Asp Gly Tyr 
        355                 360                 365             


Asn Ile Ile Val Gly Gly Asn Ser Leu Gly Arg Gly Leu Thr Phe Asn 
    370                 375                 380                 


Asn Leu Gln Thr Val Phe Tyr Val Arg Glu Ser Lys Arg Pro Gln Ala 
385                 390                 395                 400 


Asp Thr Leu Trp Gln His Ala Arg Met Phe Gly Tyr Lys Arg His Lys 
                405                 410                 415     


Asp Thr Met Arg Val Phe Met Pro Ala Thr Ile Ala Gln Thr Phe Gln 
            420                 425                 430         


Glu Val Tyr Leu Gly Asn Glu Ala Ile Lys Asn Gln Leu Asp His Gly 
        435                 440                 445             


Thr His Ile Asn Asp Ile Arg Val Ile Leu Gly Asp Gly Val Ala Pro 
    450                 455                 460                 


Thr Arg Ala Asn Val Leu Asp Lys Arg Lys Val Gly Asn Leu Ser Gly 
465                 470                 475                 480 


Gly Val Asn Tyr Phe Ala Ala Asp Pro Arg Ile Lys Asn Val Glu Ala 
                485                 490                 495     


Leu Asp Lys Lys Leu Leu Ala Tyr Leu Asp Lys His Gly Glu Asp Ser 
            500                 505                 510         


Thr Ile Gly Met Arg Ala Ile Ile Thr Ile Leu Asn Ala Phe Thr Val 
        515                 520                 525             


Asp Pro Asn Asp Leu Asp Leu Ala Thr Phe Lys Ala Ala Leu Leu Asp 
    530                 535                 540                 


Phe Glu Arg Asn Gln Pro His Leu Thr Ala Arg Met Val Leu Arg Thr 
545                 550                 555                 560 


Asn Arg Lys Val Asn Gln Gly Thr Gly Ala Leu Leu Ser Pro Thr Asp 
                565                 570                 575     


Gln Ala Leu Ser Arg Ala Glu Val Ala His Pro Leu Leu Ile Leu Tyr 
            580                 585                 590         


Arg Ile Glu Gly Val Asn Asp Ala Ala Ala Gln Arg Gly Glu Pro Thr 
        595                 600                 605             


Trp Ser Ser Asp Pro Ile Trp Val Pro Asn Ile Lys Leu Pro Gly Gln 
    610                 615                 620                 


Arg Gln Phe Trp Cys Val Asp Gly 
625                 630         


<210>  13
<211>  555
<212>  DNA
<213>  Unknown

<220>
<223>  Orotate phosphoribosyltransferase pyrE; CGL_RS13820, ncgl2676, 
       cgl2773

<400>  13
atgtcatcta attccattaa cgcagaagcg cgcgctgagc ttgctgaact gatcaaagag       60

ctagctgtcg tccacggtga agtcaccttg tcttcgggca agaaggctga ttactacatc      120

gatgtccgtc gtgccacctt gcacgcgcgc gcatctcgcc tgatcggtca gctgctgcgc      180

gaagccaccg ctgactggga ctatgacgca gttggcggcc tgaccttggg cgctgacccg      240

gttgccaccg ccatcatgca cgccgacggc cgcgatatca acgcgtttgt ggtgcgcaag      300

gaggccaaga agcacggcat gcagcgtcgc attgagggcc ctgacctgac gggcaagaag      360

gtgctcgtgg tggaagatac caccaccacc ggaaattccc ctctgacagc tgttgccgcg      420

ttgcgtgaag ctggcattga ggttgtgggc gttgccaccg tggtcgatcg cgcaaccggt      480

gcagatgagg ttatcgcagc ggaaggcctt ccttaccgca gcttgctggg actttctgat      540

cttggactca actaa                                                       555


<210>  14
<211>  184
<212>  PRT
<213>  Unknown

<220>
<223>  Orotate phosphoribosyltransferase pyrE; CGL_RS13820, ncgl2676, 
       cgl2773

<400>  14

Met Ser Ser Asn Ser Ile Asn Ala Glu Ala Arg Ala Glu Leu Ala Glu 
1               5                   10                  15      


Leu Ile Lys Glu Leu Ala Val Val His Gly Glu Val Thr Leu Ser Ser 
            20                  25                  30          


Gly Lys Lys Ala Asp Tyr Tyr Ile Asp Val Arg Arg Ala Thr Leu His 
        35                  40                  45              


Ala Arg Ala Ser Arg Leu Ile Gly Gln Leu Leu Arg Glu Ala Thr Ala 
    50                  55                  60                  


Asp Trp Asp Tyr Asp Ala Val Gly Gly Leu Thr Leu Gly Ala Asp Pro 
65                  70                  75                  80  


Val Ala Thr Ala Ile Met His Ala Asp Gly Arg Asp Ile Asn Ala Phe 
                85                  90                  95      


Val Val Arg Lys Glu Ala Lys Lys His Gly Met Gln Arg Arg Ile Glu 
            100                 105                 110         


Gly Pro Asp Leu Thr Gly Lys Lys Val Leu Val Val Glu Asp Thr Thr 
        115                 120                 125             


Thr Thr Gly Asn Ser Pro Leu Thr Ala Val Ala Ala Leu Arg Glu Ala 
    130                 135                 140                 


Gly Ile Glu Val Val Gly Val Ala Thr Val Val Asp Arg Ala Thr Gly 
145                 150                 155                 160 


Ala Asp Glu Val Ile Ala Ala Glu Gly Leu Pro Tyr Arg Ser Leu Leu 
                165                 170                 175     


Gly Leu Ser Asp Leu Gly Leu Asn 
            180                 


<210>  15
<211>  2085
<212>  DNA
<213>  Unknown

<220>
<223>  5'-nucleotidase ushA; cgl0328- CGL_RS01710, ncgl0322, cg0397

<400>  15
atgaagaggc tttcccgtgc agccctcgca gtggtcgcca ccaccgcagt tagcttcagc       60

gcactcgcag ttccagcttt cgcagacgaa gcaagcaatg ttgagctcaa catcctcggt      120

gtcaccgact tccacggaca catcgagcag aaggctgtta aagatgataa gggagtaatc      180

accggttact cagaaatggg tgccagtggc gttgcctgct acgtcgacgc tgaacgcgcg      240

gacaacccaa acacccgctt catcaccgtt ggtgacaaca ttggtggatc cccattcgtg      300

tcctccatcc tgaaggatga gccaaccttg caagccctca gcgccatcgg tgttgacgca      360

tccgcactgg gcaatcacga attcgaccag ggctactcag acctggtgaa ccgcgtttcc      420

ctcgacggct ccggcagcgc aaagttccca tacctcggcg caaacgttga aggtggcacc      480

ccagcacctg caaagtctga aatcatcgag atggacggcg tcaagatcgc ttacgtcggc      540

gcagtaaccg aggagaccgc aaccttggtc tccccagcag gcatcgaagg catcaccttc      600

accggcgaca tcgacgctat caacgcagaa gcagatcgcg tcattgaggc aggcgaagca      660

gacgtagtca tcgcattgat ccacgctgaa gccgctccaa ccgatctatt ctccaacaac      720

gttgacgttg tattctccgg acacacccac ttcgactacg ttgctgaagg cgaagcacgt      780

ggcgacaagc agccactcgt tgtcatccag ggccacgaat acggcaaggt catctccgac      840

gtggagatct cctacgaccg cgaagcaggc aagatcacca acattgaggc gaagaatgtc      900

tctgctactg acgttgtgga aaactgtgag actccaaaca cagcagtcga cgcaatcgtt      960

gcagctgctg ttgaggccgc tgaagaagca ggtaatgaag ttgttgcaac cattgacaac     1020

ggcttctacc gtggggcgga tgaagagggt acgaccggct ccaaccgtgg tgttgagtct     1080

tccctgagca acctcatcgc agaagctgga ctgtgggcag tcaacgacgc gaccatcctg     1140

aacgctgaca tcggcatcat gaacgcaggc ggcgtgcgtg cggacctcga agcaggcgaa     1200

gttaccttcg cagatgcata cgcaacccag aacttctcca acacctacgg cgtacgtgaa     1260

gtgtctggtg cgcagttcaa agaagcactg gaacagcagt ggaaggaaac cggcgaccgc     1320

ccacgtctgg cattgggact gtccagcaac gtccagtact cctacgacga gacccgcgaa     1380

tacggcgacc gcatcaccca catcaccttc aacggtgagc caatggatat gaaggagacc     1440

taccgcgtca caggatcatc cttcctgctc gcaggtggcg actccttcac tgcattcgct     1500

gaaggcggcc caatcgctga aaccggcatg gttgacattg acctgttcaa caactacatc     1560

gcagctcacc cagatgcacc aattcgtgca aatcagagct cagtaggcat cgccctttcc     1620

ggcccggcag ttgcagaaga cggaactttg gtccctggtg aagagctgac cgtcgatctt     1680

tcttccctct cctacaccgg acctgaagct aagccaacca ccgttgaggt gaccgttggt     1740

actgagaaga agactgcgga cgtcgataac accatcgttc ctcagtttga cagcaccggc     1800

aaggcaactg tcaccctgac tgttcctgag ggagctacct ctgtcaagat cgcaactgac     1860

aatggcacta cctttgaact gccagtaacc gtaaacggtg aaggcaacaa tgatgacgat     1920

gatgataagg agcagcagtc ctccggatcc tccgacgccg gttcccttgt agcagttctc     1980

ggtgttcttg gagcactcgg tggcctggtg gcgttcttcc tgaactctgc gcagggcgca     2040

ccattcttgg ctcagcttca ggctatgttt gcgcagttca tgtaa                     2085


<210>  16
<211>  694
<212>  PRT
<213>  Unknown

<220>
<223>  5'-nucleotidase ushA; cgl0328- CGL_RS01710, ncgl0322, cg0397

<400>  16

Met Lys Arg Leu Ser Arg Ala Ala Leu Ala Val Val Ala Thr Thr Ala 
1               5                   10                  15      


Val Ser Phe Ser Ala Leu Ala Val Pro Ala Phe Ala Asp Glu Ala Ser 
            20                  25                  30          


Asn Val Glu Leu Asn Ile Leu Gly Val Thr Asp Phe His Gly His Ile 
        35                  40                  45              


Glu Gln Lys Ala Val Lys Asp Asp Lys Gly Val Ile Thr Gly Tyr Ser 
    50                  55                  60                  


Glu Met Gly Ala Ser Gly Val Ala Cys Tyr Val Asp Ala Glu Arg Ala 
65                  70                  75                  80  


Asp Asn Pro Asn Thr Arg Phe Ile Thr Val Gly Asp Asn Ile Gly Gly 
                85                  90                  95      


Ser Pro Phe Val Ser Ser Ile Leu Lys Asp Glu Pro Thr Leu Gln Ala 
            100                 105                 110         


Leu Ser Ala Ile Gly Val Asp Ala Ser Ala Leu Gly Asn His Glu Phe 
        115                 120                 125             


Asp Gln Gly Tyr Ser Asp Leu Val Asn Arg Val Ser Leu Asp Gly Ser 
    130                 135                 140                 


Gly Ser Ala Lys Phe Pro Tyr Leu Gly Ala Asn Val Glu Gly Gly Thr 
145                 150                 155                 160 


Pro Ala Pro Ala Lys Ser Glu Ile Ile Glu Met Asp Gly Val Lys Ile 
                165                 170                 175     


Ala Tyr Val Gly Ala Val Thr Glu Glu Thr Ala Thr Leu Val Ser Pro 
            180                 185                 190         


Ala Gly Ile Glu Gly Ile Thr Phe Thr Gly Asp Ile Asp Ala Ile Asn 
        195                 200                 205             


Ala Glu Ala Asp Arg Val Ile Glu Ala Gly Glu Ala Asp Val Val Ile 
    210                 215                 220                 


Ala Leu Ile His Ala Glu Ala Ala Pro Thr Asp Leu Phe Ser Asn Asn 
225                 230                 235                 240 


Val Asp Val Val Phe Ser Gly His Thr His Phe Asp Tyr Val Ala Glu 
                245                 250                 255     


Gly Glu Ala Arg Gly Asp Lys Gln Pro Leu Val Val Ile Gln Gly His 
            260                 265                 270         


Glu Tyr Gly Lys Val Ile Ser Asp Val Glu Ile Ser Tyr Asp Arg Glu 
        275                 280                 285             


Ala Gly Lys Ile Thr Asn Ile Glu Ala Lys Asn Val Ser Ala Thr Asp 
    290                 295                 300                 


Val Val Glu Asn Cys Glu Thr Pro Asn Thr Ala Val Asp Ala Ile Val 
305                 310                 315                 320 


Ala Ala Ala Val Glu Ala Ala Glu Glu Ala Gly Asn Glu Val Val Ala 
                325                 330                 335     


Thr Ile Asp Asn Gly Phe Tyr Arg Gly Ala Asp Glu Glu Gly Thr Thr 
            340                 345                 350         


Gly Ser Asn Arg Gly Val Glu Ser Ser Leu Ser Asn Leu Ile Ala Glu 
        355                 360                 365             


Ala Gly Leu Trp Ala Val Asn Asp Ala Thr Ile Leu Asn Ala Asp Ile 
    370                 375                 380                 


Gly Ile Met Asn Ala Gly Gly Val Arg Ala Asp Leu Glu Ala Gly Glu 
385                 390                 395                 400 


Val Thr Phe Ala Asp Ala Tyr Ala Thr Gln Asn Phe Ser Asn Thr Tyr 
                405                 410                 415     


Gly Val Arg Glu Val Ser Gly Ala Gln Phe Lys Glu Ala Leu Glu Gln 
            420                 425                 430         


Gln Trp Lys Glu Thr Gly Asp Arg Pro Arg Leu Ala Leu Gly Leu Ser 
        435                 440                 445             


Ser Asn Val Gln Tyr Ser Tyr Asp Glu Thr Arg Glu Tyr Gly Asp Arg 
    450                 455                 460                 


Ile Thr His Ile Thr Phe Asn Gly Glu Pro Met Asp Met Lys Glu Thr 
465                 470                 475                 480 


Tyr Arg Val Thr Gly Ser Ser Phe Leu Leu Ala Gly Gly Asp Ser Phe 
                485                 490                 495     


Thr Ala Phe Ala Glu Gly Gly Pro Ile Ala Glu Thr Gly Met Val Asp 
            500                 505                 510         


Ile Asp Leu Phe Asn Asn Tyr Ile Ala Ala His Pro Asp Ala Pro Ile 
        515                 520                 525             


Arg Ala Asn Gln Ser Ser Val Gly Ile Ala Leu Ser Gly Pro Ala Val 
    530                 535                 540                 


Ala Glu Asp Gly Thr Leu Val Pro Gly Glu Glu Leu Thr Val Asp Leu 
545                 550                 555                 560 


Ser Ser Leu Ser Tyr Thr Gly Pro Glu Ala Lys Pro Thr Thr Val Glu 
                565                 570                 575     


Val Thr Val Gly Thr Glu Lys Lys Thr Ala Asp Val Asp Asn Thr Ile 
            580                 585                 590         


Val Pro Gln Phe Asp Ser Thr Gly Lys Ala Thr Val Thr Leu Thr Val 
        595                 600                 605             


Pro Glu Gly Ala Thr Ser Val Lys Ile Ala Thr Asp Asn Gly Thr Thr 
    610                 615                 620                 


Phe Glu Leu Pro Val Thr Val Asn Gly Glu Gly Asn Asn Asp Asp Asp 
625                 630                 635                 640 


Asp Asp Lys Glu Gln Gln Ser Ser Gly Ser Ser Asp Ala Gly Ser Leu 
                645                 650                 655     


Val Ala Val Leu Gly Val Leu Gly Ala Leu Gly Gly Leu Val Ala Phe 
            660                 665                 670         


Phe Leu Asn Ser Ala Gln Gly Ala Pro Phe Leu Ala Gln Leu Gln Ala 
        675                 680                 685             


Met Phe Ala Gln Phe Met 
    690                 


<210>  17
<211>  693
<212>  DNA
<213>  Unknown

<220>
<223>  Nicotinamide ribose transporter pnuC; ncgl0063, CGL_RS00355, 
       cgl0064

<400>  17
atgaatccta taaccgaatt attagacgca acactatgga tcggcggagt tccgattctg       60

tggcgcgaaa tcatcggcaa cgttttcgga ttatttagcg cgtgggcagg aatgcgacgc      120

atcgtgtggg catggcccat cggcatcata ggcaacgcgc tgctgttcac agtatttatg      180

ggcggccttt tccacactcc acaaaacctc gatctctacg gccaagcggg tcgccagatc      240

atgttcatca tcgtcagtgg ttatggctgg taccaatggt cggccgcaaa acgtcgcgca      300

ctcaccccag aaaatgcagt agcagtggtt cctcgctggg caagcaccaa agaacgcgcc      360

ggcattgtga ttgcggcggt tgtgggaaca ctcagctttg cctggatttt ccaagcactc      420

ggctcctggg ggccatgggc cgacgcgtgg attttcgtcg gctcaatcct ggctacctac      480

ggaatggctc gcggatggac agagttctgg ctgatctgga tcgccgtcga catagttggc      540

gttcctctac ttttgactgc tggctactac ccatccgcgg tgctttacct ggtgtacggt      600

gcgtttgtca gctggggatt tgtcgtgtgg ctgcgggtgc aaaaagcaga caaggctcgt      660

gcgctggaag ctcaggagtc tgtgacagtc tga                                   693


<210>  18
<211>  230
<212>  PRT
<213>  Unknown

<220>
<223>  Nicotinamide ribose transporter pnuC; ncgl0063, CGL_RS00355, 
       cgl0064

<400>  18

Met Asn Pro Ile Thr Glu Leu Leu Asp Ala Thr Leu Trp Ile Gly Gly 
1               5                   10                  15      


Val Pro Ile Leu Trp Arg Glu Ile Ile Gly Asn Val Phe Gly Leu Phe 
            20                  25                  30          


Ser Ala Trp Ala Gly Met Arg Arg Ile Val Trp Ala Trp Pro Ile Gly 
        35                  40                  45              


Ile Ile Gly Asn Ala Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe 
    50                  55                  60                  


His Thr Pro Gln Asn Leu Asp Leu Tyr Gly Gln Ala Gly Arg Gln Ile 
65                  70                  75                  80  


Met Phe Ile Ile Val Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala 
                85                  90                  95      


Lys Arg Arg Ala Leu Thr Pro Glu Asn Ala Val Ala Val Val Pro Arg 
            100                 105                 110         


Trp Ala Ser Thr Lys Glu Arg Ala Gly Ile Val Ile Ala Ala Val Val 
        115                 120                 125             


Gly Thr Leu Ser Phe Ala Trp Ile Phe Gln Ala Leu Gly Ser Trp Gly 
    130                 135                 140                 


Pro Trp Ala Asp Ala Trp Ile Phe Val Gly Ser Ile Leu Ala Thr Tyr 
145                 150                 155                 160 


Gly Met Ala Arg Gly Trp Thr Glu Phe Trp Leu Ile Trp Ile Ala Val 
                165                 170                 175     


Asp Ile Val Gly Val Pro Leu Leu Leu Thr Ala Gly Tyr Tyr Pro Ser 
            180                 185                 190         


Ala Val Leu Tyr Leu Val Tyr Gly Ala Phe Val Ser Trp Gly Phe Val 
        195                 200                 205             


Val Trp Leu Arg Val Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala 
    210                 215                 220                 


Gln Glu Ser Val Thr Val 
225                 230 


<210>  19
<211>  939
<212>  DNA
<213>  Unknown

<220>
<223>  Purine nucleosidase iunH3; cgl1364 (CGL_RS06810, ncgl1309, 
       cg1543, iunH3)

<400>  19
atgaccacca agatcatcct cgactgcgat ccaggacacg acgacgctgt agccatgctg       60

ctcgcagccg gcagcccaga aattgaactg cttggaatca ccacggtcgg cggcaaccag      120

accttggaca aggtcaccca caatacgcag gtcgtagcca ccatcgctga tatcaatgcg      180

cccatctacc gcggtgtcac ccgaccattg gtgcgccccg ttgaggtagc cgaagatatc      240

cacggcgata ccggcatgga aatccacaag tacgaactgc ctgaaccaac caagcaggta      300

gaagacaccc acgcggtgga tttcatcatc gataccatca tgaataacga gcccggcagc      360

gtagcgctgg ttcccaccgg accactgacc aacatcgcgc tggcagtccg gaaagaacca      420

cgcatcgccg agcgagtcaa ggaagttgtc ctcatgggcg ggggctacca cgtaggaaac      480

tggaccgccg tagctgaatt caacatcaag atcgaccccg aagcagccca catcgtattc      540

aacgaaaagt ggccactgac tatggtcggc ctcgacctta cccaccaggc gctcgcaaca      600

cctgagatcg aagccaagtt caacgagctg ggcaccgacg tcgccgactt cgtcgtcgcg      660

cttttcgacg ctttccgcaa gaattaccag gacgcacagg gttttgataa cccaccagta      720

cacgaccctt gtgctgttgc ataccttgtt gacccaaccg tattcaccac ccgcaaagca      780

ccactcgatg tggagctgta cggcgcactc accacaggca tgaccgttgc tgatttccgc      840

gcaccggctc cagcagattg caccacccaa gtagctgttg acctggactt tgataaattc      900

tggaacatgg tgatcgatgc agtaaagcgc atcggatag                             939


<210>  20
<211>  312
<212>  PRT
<213>  Unknown

<220>
<223>  Purine nucleosidase iunH3; cgl1364 (CGL_RS06810, ncgl1309, 
       cg1543, iunH3)

<400>  20

Met Thr Thr Lys Ile Ile Leu Asp Cys Asp Pro Gly His Asp Asp Ala 
1               5                   10                  15      


Val Ala Met Leu Leu Ala Ala Gly Ser Pro Glu Ile Glu Leu Leu Gly 
            20                  25                  30          


Ile Thr Thr Val Gly Gly Asn Gln Thr Leu Asp Lys Val Thr His Asn 
        35                  40                  45              


Thr Gln Val Val Ala Thr Ile Ala Asp Ile Asn Ala Pro Ile Tyr Arg 
    50                  55                  60                  


Gly Val Thr Arg Pro Leu Val Arg Pro Val Glu Val Ala Glu Asp Ile 
65                  70                  75                  80  


His Gly Asp Thr Gly Met Glu Ile His Lys Tyr Glu Leu Pro Glu Pro 
                85                  90                  95      


Thr Lys Gln Val Glu Asp Thr His Ala Val Asp Phe Ile Ile Asp Thr 
            100                 105                 110         


Ile Met Asn Asn Glu Pro Gly Ser Val Ala Leu Val Pro Thr Gly Pro 
        115                 120                 125             


Leu Thr Asn Ile Ala Leu Ala Val Arg Lys Glu Pro Arg Ile Ala Glu 
    130                 135                 140                 


Arg Val Lys Glu Val Val Leu Met Gly Gly Gly Tyr His Val Gly Asn 
145                 150                 155                 160 


Trp Thr Ala Val Ala Glu Phe Asn Ile Lys Ile Asp Pro Glu Ala Ala 
                165                 170                 175     


His Ile Val Phe Asn Glu Lys Trp Pro Leu Thr Met Val Gly Leu Asp 
            180                 185                 190         


Leu Thr His Gln Ala Leu Ala Thr Pro Glu Ile Glu Ala Lys Phe Asn 
        195                 200                 205             


Glu Leu Gly Thr Asp Val Ala Asp Phe Val Val Ala Leu Phe Asp Ala 
    210                 215                 220                 


Phe Arg Lys Asn Tyr Gln Asp Ala Gln Gly Phe Asp Asn Pro Pro Val 
225                 230                 235                 240 


His Asp Pro Cys Ala Val Ala Tyr Leu Val Asp Pro Thr Val Phe Thr 
                245                 250                 255     


Thr Arg Lys Ala Pro Leu Asp Val Glu Leu Tyr Gly Ala Leu Thr Thr 
            260                 265                 270         


Gly Met Thr Val Ala Asp Phe Arg Ala Pro Ala Pro Ala Asp Cys Thr 
        275                 280                 285             


Thr Gln Val Ala Val Asp Leu Asp Phe Asp Lys Phe Trp Asn Met Val 
    290                 295                 300                 


Ile Asp Ala Val Lys Arg Ile Gly 
305                 310         


<210>  21
<211>  951
<212>  DNA
<213>  Unknown

<220>
<223>  Purine nucleosidase iunH2; cgl1977 (cg2168, iunH2, CYL77_RS09970)

<400>  21
atgagcaaaa aagccatcct tgatatcgac accggcatcg atgatgccct cgcacttgcc       60

tacgcactgg gctcacctga actagagctc attggtgtca ccaccaccta cggtaacgtg      120

ctactcgaaa ccggtgcagt caatgacctg gcactgcttg atctgttcgg tgcaccagaa      180

gtacctgtgt acttgggtga gccacacgca cagaccaagg atggctttga agttcttgag      240

atctccgcgt tcattcacgg acaaaacggc atcggcgaag tcgagctgcc agcaagcgag      300

tcaaaggcac tccccggcgc agtggatttc ctcattgatt ccgtcaacac ccacggcgat      360

gacctggtga tcatcgcaac tggtcccatg accaacctgt ctgcggcaat cgcaaaggat      420

ccaagctttg cttccaaggc tcacgtggtc atcatgggtg gcgccttgac tgtcccaggc      480

aacgtcagca catgggcaga agcaaacatc aaccaggacc cagatgcagc aaacgatctg      540

ttccgttccg gtgcagatgt caccatgatc ggtcttgatg tcaccctgca gacccttctt      600

accaagaagc acactgcgca gtggcgcgaa ctgggcactc cagctgctat cgcactggcc      660

gacatgactg attactacat caaggcatat gagaccaccg caccacacct gggcggttgc      720

ggcctgcacg acccactggc agtaggcgtt gcagtggacc caagcctggt cactttgctc      780

cccatcaacc tcaaggtaga cattgagggc gagacccgtg gacgcaccat tggcgatgaa      840

gtccgcctca acgatccagt gcgcacctcc cgcgcagctg tcgccgtaga cgtggatcgt      900

ttcctttctg aattcatgac ccgcatcggc cgagtcgcag cacagcagta a               951


<210>  22
<211>  316
<212>  PRT
<213>  Unknown

<220>
<223>  Purine nucleosidase iunH2; cgl1977 (cg2168, iunH2, CYL77_RS09970)

<400>  22

Met Ser Lys Lys Ala Ile Leu Asp Ile Asp Thr Gly Ile Asp Asp Ala 
1               5                   10                  15      


Leu Ala Leu Ala Tyr Ala Leu Gly Ser Pro Glu Leu Glu Leu Ile Gly 
            20                  25                  30          


Val Thr Thr Thr Tyr Gly Asn Val Leu Leu Glu Thr Gly Ala Val Asn 
        35                  40                  45              


Asp Leu Ala Leu Leu Asp Leu Phe Gly Ala Pro Glu Val Pro Val Tyr 
    50                  55                  60                  


Leu Gly Glu Pro His Ala Gln Thr Lys Asp Gly Phe Glu Val Leu Glu 
65                  70                  75                  80  


Ile Ser Ala Phe Ile His Gly Gln Asn Gly Ile Gly Glu Val Glu Leu 
                85                  90                  95      


Pro Ala Ser Glu Ser Lys Ala Leu Pro Gly Ala Val Asp Phe Leu Ile 
            100                 105                 110         


Asp Ser Val Asn Thr His Gly Asp Asp Leu Val Ile Ile Ala Thr Gly 
        115                 120                 125             


Pro Met Thr Asn Leu Ser Ala Ala Ile Ala Lys Asp Pro Ser Phe Ala 
    130                 135                 140                 


Ser Lys Ala His Val Val Ile Met Gly Gly Ala Leu Thr Val Pro Gly 
145                 150                 155                 160 


Asn Val Ser Thr Trp Ala Glu Ala Asn Ile Asn Gln Asp Pro Asp Ala 
                165                 170                 175     


Ala Asn Asp Leu Phe Arg Ser Gly Ala Asp Val Thr Met Ile Gly Leu 
            180                 185                 190         


Asp Val Thr Leu Gln Thr Leu Leu Thr Lys Lys His Thr Ala Gln Trp 
        195                 200                 205             


Arg Glu Leu Gly Thr Pro Ala Ala Ile Ala Leu Ala Asp Met Thr Asp 
    210                 215                 220                 


Tyr Tyr Ile Lys Ala Tyr Glu Thr Thr Ala Pro His Leu Gly Gly Cys 
225                 230                 235                 240 


Gly Leu His Asp Pro Leu Ala Val Gly Val Ala Val Asp Pro Ser Leu 
                245                 250                 255     


Val Thr Leu Leu Pro Ile Asn Leu Lys Val Asp Ile Glu Gly Glu Thr 
            260                 265                 270         


Arg Gly Arg Thr Ile Gly Asp Glu Val Arg Leu Asn Asp Pro Val Arg 
        275                 280                 285             


Thr Ser Arg Ala Ala Val Ala Val Asp Val Asp Arg Phe Leu Ser Glu 
    290                 295                 300                 


Phe Met Thr Arg Ile Gly Arg Val Ala Ala Gln Gln 
305                 310                 315     


<210>  23
<211>  905
<212>  DNA
<213>  Unknown

<220>
<223>  Purine nucleosidase iunH1; cgl2835 (cg3137, iunH1, CYL77_RS14340)

<400>  23
atgattcctg ttctcatcga ctgcgacacc ggcatcgacg acgccctcgc cctgatctac       60

ctggttgctt tgcataaacg tggtgaaatc caactttttg gagcaacgac caccgcagga      120

aatgttgatg tgaaacaaac cgcctcaata ccaggtgggt gttggatcag tgtggattag      180

cggacatccc ggtcctcgca ggacaacctg aaccaaagca cgtgccgcta gtgactactc      240

cagaaacaca cggcgaccat ggccttggtt atataaaccc aggtcacgtc gaaattccag      300

aaggtgactg gaagcagctg tggaaagaac acctcagtaa cccagaaact aagctgattg      360

tcaccgggcc cgccaccaac cttgcggaat tcgggccagt ggaaaacgtc acgctgatgg      420

gtggcaccta cctttatcca ggcaacacca ctccaacggc agaatggaat acctgggttg      480

atccacacgg agctaaagaa gcattcgcgg cagcccaaaa gcccattacg gtgtgttcct      540

tgggcgtgac cgagcagttt acgctgaacc cggacatcct ttctacactt atcaacacgc      600

ttggcagcca acccatcgca gagcatttac ctgagatgct gcgcttttac tttgaatttc      660

acgaagtgca gggcgaaggt taccttgctc aaattcatga cctgctgacc tgcatgattg      720

ccttggataa aatcccattt tcaggccgtg aagtaaccgt ggacgtggag gctgattcgc      780

ccttgatgcg tggcaccact gttgcagata ttcgcggaca ttggggcaag ccagctaacg      840

catttcttgt ggaaaccgca gacattgagg ccgcccacgc ggaacttcta agagcagtgg      900

aatga                                                                  905


<210>  24
<211>  301
<212>  PRT
<213>  Unknown

<220>
<223>  Purine nucleosidase iunH1; cgl2835 (cg3137, iunH1, CYL77_RS14340)

<400>  24

Met Ile Pro Val Leu Ile Asp Cys Asp Thr Gly Ile Asp Asp Ala Leu 
1               5                   10                  15      


Ala Leu Ile Tyr Leu Val Ala Leu His Lys Arg Gly Glu Ile Gln Leu 
            20                  25                  30          


Phe Gly Ala Thr Thr Thr Ala Gly Asn Val Asp Val Lys Gln Thr Ala 
        35                  40                  45              


Ile Asn Thr Arg Trp Val Leu Asp Gln Cys Gly Leu Ala Asp Ile Pro 
    50                  55                  60                  


Val Leu Ala Gly Gln Pro Glu Pro Lys His Val Pro Leu Val Thr Thr 
65                  70                  75                  80  


Pro Glu Thr His Gly Asp His Gly Leu Gly Tyr Ile Asn Pro Gly His 
                85                  90                  95      


Val Glu Ile Pro Glu Gly Asp Trp Lys Gln Leu Trp Lys Glu His Leu 
            100                 105                 110         


Ser Asn Pro Glu Thr Lys Leu Ile Val Thr Gly Pro Ala Thr Asn Leu 
        115                 120                 125             


Ala Glu Phe Gly Pro Val Glu Asn Val Thr Leu Met Gly Gly Thr Tyr 
    130                 135                 140                 


Leu Tyr Pro Gly Asn Thr Thr Pro Thr Ala Glu Trp Asn Thr Trp Val 
145                 150                 155                 160 


Asp Pro His Gly Ala Lys Glu Ala Phe Ala Ala Ala Gln Lys Pro Ile 
                165                 170                 175     


Thr Val Cys Ser Leu Gly Val Thr Glu Gln Phe Thr Leu Asn Pro Asp 
            180                 185                 190         


Ile Leu Ser Thr Leu Ile Asn Thr Leu Gly Ser Gln Pro Ile Ala Glu 
        195                 200                 205             


His Leu Pro Glu Met Leu Arg Phe Tyr Phe Glu Phe His Glu Val Gln 
    210                 215                 220                 


Gly Glu Gly Tyr Leu Ala Gln Ile His Asp Leu Leu Thr Cys Met Ile 
225                 230                 235                 240 


Ala Leu Asp Lys Ile Pro Phe Ser Gly Arg Glu Val Thr Val Asp Val 
                245                 250                 255     


Glu Ala Asp Ser Pro Leu Met Arg Gly Thr Thr Val Ala Asp Ile Arg 
            260                 265                 270         


Gly His Trp Gly Lys Pro Ala Asn Ala Phe Leu Val Glu Thr Ala Asp 
        275                 280                 285             


Ile Glu Ala Ala His Ala Glu Leu Leu Arg Ala Val Glu 
    290                 295                 300     


<210>  25
<211>  1623
<212>  DNA
<213>  Unknown

<220>
<223>  Glucose-6P isomerase pgi; cgl0851 (ncgl0817)

<400>  25
atggcggaca tttcgaccac ccaggtttgg caagacctga ccgatcatta ctcaaacttc       60

caggcaacca ctctgcgtga acttttcaag gaagaaaacc gcgccgagaa gtacaccttc      120

tccgcggctg gcctccacgt cgacctgtcg aagaatctgc ttgacgacgc caccctcacc      180

aagctccttg cactgaccga agaatctggc cttcgcgaac gcattgacgc gatgtttgcc      240

ggtgaacacc tcaacaacac cgaagaccgc gctgtcctcc acaccgcgct gcgccttcct      300

gccgaagctg atctgtcagt agatggccaa gatgttgctg ctgatgtcca cgaagttttg      360

ggacgcatgc gtgacttcgc tactgcgctg cgctcaggca actggttggg acacaccggc      420

cacacgatca agaagatcgt caacattggt atcggtggct ctgacctcgg accagccatg      480

gctacgaagg ctctgcgtgc atacgcgacc gctggtatct cagcagaatt cgtctccaac      540

gtcgacccag cagacctcgt ttctgtgttg gaagacctcg atgcagaatc cacattgttc      600

gtgatcgctt cgaaaacttt caccacccag gagacgctgt ccaacgctcg tgcagctcgt      660

gcttggctgg tagagaagct cggtgaagag gctgtcgcga agcacttcgt cgcagtgtcc      720

accaatgctg aaaaggtcgc agagttcggt atcgacacgg acaacatgtt cggcttctgg      780

gactgggtcg gaggtcgtta ctccgtggac tccgcagttg gtctttccct catggcagtg      840

atcggccctc gcgacttcat gcgtttcctc ggtggattcc acgcgatgga tgaacacttc      900

cgcaccacca agttcgaaga gaacgttcca atcttgatgg ctctgctcgg tgtctggtac      960

tccgatttct atggtgcaga aacccacgct gtcctacctt attccgagga tctcagccgt     1020

tttgctgctt acctccagca gctgaccatg gaatcaaatg gcaagtcagt ccaccgcgac     1080

ggctcccctg tttccactgg cactggcgaa atttactggg gtgagcctgg cacaaatggc     1140

cagcacgctt tcttccagct gatccaccag ggcactcgcc ttgttccagc tgatttcatt     1200

ggtttcgctc gtccaaagca ggatcttcct gccggtgagc gcaccatgca tgaccttttg     1260

atgagcaact tcttcgcaca gaccaaggtt ttggctttcg gtaagaacgc tgaagagatc     1320

gctgcggaag gtgtcgcacc tgagctggtc aaccacaagg tcatgccagg taatcgccca     1380

accaccacca ttttggcgga ggaacttacc ccttctattc tcggtgcgtt gatcgctttg     1440

tacgaacaca tcgtgatggt tcagggcgtg atttgggaca tcaactcctt cgaccaatgg     1500

ggtgttgaac tgggcaaaca gcaggcaaat gacctcgctc cggctgtctc tggtgaagag     1560

gatgttgact cgggagattc ttccactgat tcactgatta agtggtaccg cgcaaatagg     1620

tag                                                                   1623


<210>  26
<211>  540
<212>  PRT
<213>  Unknown

<220>
<223>  Glucose-6P isomerase PGI; cgl0851 (ncgl0817)

<400>  26

Met Ala Asp Ile Ser Thr Thr Gln Val Trp Gln Asp Leu Thr Asp His 
1               5                   10                  15      


Tyr Ser Asn Phe Gln Ala Thr Thr Leu Arg Glu Leu Phe Lys Glu Glu 
            20                  25                  30          


Asn Arg Ala Glu Lys Tyr Thr Phe Ser Ala Ala Gly Leu His Val Asp 
        35                  40                  45              


Leu Ser Lys Asn Leu Leu Asp Asp Ala Thr Leu Thr Lys Leu Leu Ala 
    50                  55                  60                  


Leu Thr Glu Glu Ser Gly Leu Arg Glu Arg Ile Asp Ala Met Phe Ala 
65                  70                  75                  80  


Gly Glu His Leu Asn Asn Thr Glu Asp Arg Ala Val Leu His Thr Ala 
                85                  90                  95      


Leu Arg Leu Pro Ala Glu Ala Asp Leu Ser Val Asp Gly Gln Asp Val 
            100                 105                 110         


Ala Ala Asp Val His Glu Val Leu Gly Arg Met Arg Asp Phe Ala Thr 
        115                 120                 125             


Ala Leu Arg Ser Gly Asn Trp Leu Gly His Thr Gly His Thr Ile Lys 
    130                 135                 140                 


Lys Ile Val Asn Ile Gly Ile Gly Gly Ser Asp Leu Gly Pro Ala Met 
145                 150                 155                 160 


Ala Thr Lys Ala Leu Arg Ala Tyr Ala Thr Ala Gly Ile Ser Ala Glu 
                165                 170                 175     


Phe Val Ser Asn Val Asp Pro Ala Asp Leu Val Ser Val Leu Glu Asp 
            180                 185                 190         


Leu Asp Ala Glu Ser Thr Leu Phe Val Ile Ala Ser Lys Thr Phe Thr 
        195                 200                 205             


Thr Gln Glu Thr Leu Ser Asn Ala Arg Ala Ala Arg Ala Trp Leu Val 
    210                 215                 220                 


Glu Lys Leu Gly Glu Glu Ala Val Ala Lys His Phe Val Ala Val Ser 
225                 230                 235                 240 


Thr Asn Ala Glu Lys Val Ala Glu Phe Gly Ile Asp Thr Asp Asn Met 
                245                 250                 255     


Phe Gly Phe Trp Asp Trp Val Gly Gly Arg Tyr Ser Val Asp Ser Ala 
            260                 265                 270         


Val Gly Leu Ser Leu Met Ala Val Ile Gly Pro Arg Asp Phe Met Arg 
        275                 280                 285             


Phe Leu Gly Gly Phe His Ala Met Asp Glu His Phe Arg Thr Thr Lys 
    290                 295                 300                 


Phe Glu Glu Asn Val Pro Ile Leu Met Ala Leu Leu Gly Val Trp Tyr 
305                 310                 315                 320 


Ser Asp Phe Tyr Gly Ala Glu Thr His Ala Val Leu Pro Tyr Ser Glu 
                325                 330                 335     


Asp Leu Ser Arg Phe Ala Ala Tyr Leu Gln Gln Leu Thr Met Glu Ser 
            340                 345                 350         


Asn Gly Lys Ser Val His Arg Asp Gly Ser Pro Val Ser Thr Gly Thr 
        355                 360                 365             


Gly Glu Ile Tyr Trp Gly Glu Pro Gly Thr Asn Gly Gln His Ala Phe 
    370                 375                 380                 


Phe Gln Leu Ile His Gln Gly Thr Arg Leu Val Pro Ala Asp Phe Ile 
385                 390                 395                 400 


Gly Phe Ala Arg Pro Lys Gln Asp Leu Pro Ala Gly Glu Arg Thr Met 
                405                 410                 415     


His Asp Leu Leu Met Ser Asn Phe Phe Ala Gln Thr Lys Val Leu Ala 
            420                 425                 430         


Phe Gly Lys Asn Ala Glu Glu Ile Ala Ala Glu Gly Val Ala Pro Glu 
        435                 440                 445             


Leu Val Asn His Lys Val Met Pro Gly Asn Arg Pro Thr Thr Thr Ile 
    450                 455                 460                 


Leu Ala Glu Glu Leu Thr Pro Ser Ile Leu Gly Ala Leu Ile Ala Leu 
465                 470                 475                 480 


Tyr Glu His Ile Val Met Val Gln Gly Val Ile Trp Asp Ile Asn Ser 
                485                 490                 495     


Phe Asp Gln Trp Gly Val Glu Leu Gly Lys Gln Gln Ala Asn Asp Leu 
            500                 505                 510         


Ala Pro Ala Val Ser Gly Glu Glu Asp Val Asp Ser Gly Asp Ser Ser 
        515                 520                 525             


Thr Asp Ser Leu Ile Lys Trp Tyr Arg Ala Asn Arg 
    530                 535                 540 


<210>  27
<211>  1545
<212>  DNA
<213>  Unknown

<220>
<223>  cgZWF codon-optimized mutant (A243T) of the of the 
       glucose-6-phosphate dehydrogenase from Corynebacterium glutamicum
       (cg1778, Cgl1576, NCgl1514)

<400>  27
atgagtacca acaccacccc gtcaagctgg acaaatccat tgcgcgaccc ccaggataag       60

cgcttgcccc gcatcgcagg accctccggc atggtcattt ttggggtgac cggcgatctg      120

gcacgcaaga aactgctacc agccatctat gacttggcaa atcgcggctt actgccacct      180

ggcttctctc tcgtgggcta tggtcgccgt gaatggtcta aggaggactt cgaaaagtac      240

gttcgtgatg cagcgtccgc gggagcccga acggaatttc gtgaaaacgt ctgggaacgc      300

cttgcagaag gcatggaatt tgtccgcgga aattttgatg atgacgccgc attcgacaac      360

ttggcggcga cgctgaagcg catcgataag acgagaggca ctgctggtaa ctgggcgtac      420

tatctgtcca tcccaccgga ctcctttacg gcggtgtgcc accagctaga gcgttccggc      480

atggctgagt ccaccgaaga ggcatggcgc cgagtgatca ttgaaaagcc attcgggcac      540

aacctggaat cggcacacga gctcaaccaa ctggtcaacg ccgttttccc ggagtcatca      600

gtgtttagaa tcgatcacta cctgggtaaa gaaaccgtgc agaatatcct cgcgctgcga      660

ttcgcaaatc aactttttga acccctttgg aacagcaact atgtcgatca cgtccaaatt      720

accatgactg aagatattgg cttgggagga cgcgcgggtt attatgatgg aatcggagca      780

gcgcgcgacg tcatccagaa tcacctcatt cagctgttgg cgctggtagc gatggaggaa      840

cccattagct ttgtgcctgc tcagctgcaa gcagaaaaga tcaaagttct gagcgctacc      900

aaaccttgtt accctctgga taagacctca gctcgcggtc aatatgctgc tggctggcaa      960

ggatctgagc tggtcaaggg ccttcgtgaa gaggacggtt tcaaccccga gagcaccacg     1020

gaaaccttcg ccgcatgtac ccttgaaatc acaagtcgcc gctgggccgg cgtcccattc     1080

tacctgcgta ctggcaagag actcggccga cgagttacag agatcgctgt tgtgtttaaa     1140

gatgctcccc accagccgtt tgatggagac atgaccgttt cccttggcca aaatgcgatc     1200

gtaattcgcg tacaaccaga cgagggtgtt cttatccgct ttggttccaa ggtgcccggt     1260

tccgctatgg aggttcgtga cgttaatatg gacttcagct atagcgaatc cttcaccgaa     1320

gagtcacctg aagcatacga acgcctgatc ctggatgccc tcctggacga gtccagcttg     1380

tttccaacca acgaggaagt ggaactgtct tggaaaatcc tggacccaat tctggaagct     1440

tgggatgccg atggcgaacc ggaggactac ccagctggga cctgggggcc aaaatcggcg     1500

gatgagatgt tatcccgtaa cggccacaca tggcgccgac cttga                     1545


<210>  28
<211>  514
<212>  PRT
<213>  Unknown

<220>
<223>  cgZWF mutant (A243T) of the of the glucose-6-phosphate 
       dehydrogenase from Corynebacterium glutamicum (cg1778, Cgl1576, 
       NCgl1514)

<400>  28

Met Ser Thr Asn Thr Thr Pro Ser Ser Trp Thr Asn Pro Leu Arg Asp 
1               5                   10                  15      


Pro Gln Asp Lys Arg Leu Pro Arg Ile Ala Gly Pro Ser Gly Met Val 
            20                  25                  30          


Ile Phe Gly Val Thr Gly Asp Leu Ala Arg Lys Lys Leu Leu Pro Ala 
        35                  40                  45              


Ile Tyr Asp Leu Ala Asn Arg Gly Leu Leu Pro Pro Gly Phe Ser Leu 
    50                  55                  60                  


Val Gly Tyr Gly Arg Arg Glu Trp Ser Lys Glu Asp Phe Glu Lys Tyr 
65                  70                  75                  80  


Val Arg Asp Ala Ala Ser Ala Gly Ala Arg Thr Glu Phe Arg Glu Asn 
                85                  90                  95      


Val Trp Glu Arg Leu Ala Glu Gly Met Glu Phe Val Arg Gly Asn Phe 
            100                 105                 110         


Asp Asp Asp Ala Ala Phe Asp Asn Leu Ala Ala Thr Leu Lys Arg Ile 
        115                 120                 125             


Asp Lys Thr Arg Gly Thr Ala Gly Asn Trp Ala Tyr Tyr Leu Ser Ile 
    130                 135                 140                 


Pro Pro Asp Ser Phe Thr Ala Val Cys His Gln Leu Glu Arg Ser Gly 
145                 150                 155                 160 


Met Ala Glu Ser Thr Glu Glu Ala Trp Arg Arg Val Ile Ile Glu Lys 
                165                 170                 175     


Pro Phe Gly His Asn Leu Glu Ser Ala His Glu Leu Asn Gln Leu Val 
            180                 185                 190         


Asn Ala Val Phe Pro Glu Ser Ser Val Phe Arg Ile Asp His Tyr Leu 
        195                 200                 205             


Gly Lys Glu Thr Val Gln Asn Ile Leu Ala Leu Arg Phe Ala Asn Gln 
    210                 215                 220                 


Leu Phe Glu Pro Leu Trp Asn Ser Asn Tyr Val Asp His Val Gln Ile 
225                 230                 235                 240 


Thr Met Ala Glu Asp Ile Gly Leu Gly Gly Arg Ala Gly Tyr Tyr Asp 
                245                 250                 255     


Gly Ile Gly Ala Ala Arg Asp Val Ile Gln Asn His Leu Ile Gln Leu 
            260                 265                 270         


Leu Ala Leu Val Ala Met Glu Glu Pro Ile Ser Phe Val Pro Ala Gln 
        275                 280                 285             


Leu Gln Ala Glu Lys Ile Lys Val Leu Ser Ala Thr Lys Pro Cys Tyr 
    290                 295                 300                 


Pro Leu Asp Lys Thr Ser Ala Arg Gly Gln Tyr Ala Ala Gly Trp Gln 
305                 310                 315                 320 


Gly Ser Glu Leu Val Lys Gly Leu Arg Glu Glu Asp Gly Phe Asn Pro 
                325                 330                 335     


Glu Ser Thr Thr Glu Thr Phe Ala Ala Cys Thr Leu Glu Ile Thr Ser 
            340                 345                 350         


Arg Arg Trp Ala Gly Val Pro Phe Tyr Leu Arg Thr Gly Lys Arg Leu 
        355                 360                 365             


Gly Arg Arg Val Thr Glu Ile Ala Val Val Phe Lys Asp Ala Pro His 
    370                 375                 380                 


Gln Pro Phe Asp Gly Asp Met Thr Val Ser Leu Gly Gln Asn Ala Ile 
385                 390                 395                 400 


Val Ile Arg Val Gln Pro Asp Glu Gly Val Leu Ile Arg Phe Gly Ser 
                405                 410                 415     


Lys Val Pro Gly Ser Ala Met Glu Val Arg Asp Val Asn Met Asp Phe 
            420                 425                 430         


Ser Tyr Ser Glu Ser Phe Thr Glu Glu Ser Pro Glu Ala Tyr Glu Arg 
        435                 440                 445             


Leu Ile Leu Asp Ala Leu Leu Asp Glu Ser Ser Leu Phe Pro Thr Asn 
    450                 455                 460                 


Glu Glu Val Glu Leu Ser Trp Lys Ile Leu Asp Pro Ile Leu Glu Ala 
465                 470                 475                 480 


Trp Asp Ala Asp Gly Glu Pro Glu Asp Tyr Pro Ala Gly Thr Trp Gly 
                485                 490                 495     


Pro Lys Ser Ala Asp Glu Met Leu Ser Arg Asn Gly His Thr Trp Arg 
            500                 505                 510         


Arg Pro 
        


<210>  29
<211>  1461
<212>  DNA
<213>  Unknown

<220>
<223>  Glucose-6-phosphate dehydrogenase of Leuconoston mesenteroides, 
       codon optimized mutant (R46E/Q47E) of the gene having accession 
       number M64446.1; lmZWF

<400>  29
atggtttccg aaataaagac cctcgttact ttctttggcg gcaccggtga ccttgcaaaa       60

cgcaagctct acccctctgt attcaacctg tacaaaaaag ggtatctgca aaaacacttc      120

gccattgttg gtaccgctga agaggcgcta aacgacgacg agttcaaaca gcttgtccgt      180

gattccatta aagacttcac cgatgaccaa gcccaggcag aggccttcat cgaacatttt      240

tcttatcgag cacacgatgt gaccgatgcc gcatcgtatg cagtcctgaa ggaagcgatc      300

gaggaggcgg ccgataagtt cgatattgac ggtaaccgca tattttacat gtcggtggca      360

ccacgcttct tcggtaccat cgctaaatat ctgaagtccg agggtctgct tgctgatact      420

ggctacaatc ggctgatgat tgaaaagcct tttggaacct cttatgacac agccgcagaa      480

ctacagaatg acttggagaa cgctttcgat gataatcagc ttttccgtat cgatcattat      540

ctgggtaaag aaatggtcca gaatatcgca gctctgcgct tcggaaaccc tatattcgac      600

gctgcgtgga acaaggatta catcaagaac gttcaagtta cactctccga agtgttgggg      660

gttgaagagc gagccggcta ctatgacacc gccggagctc tacttgatat gatccagaac      720

cacacgatgc agatcgttgg ctggctcgcc atggaaaaac cagagtcctt caccgataaa      780

gacatccgcg cggctaagaa cgccgctttt aatgccctga aaatctacga cgaggctgaa      840

gtgaacaaat attttgtgcg tgcccaatat ggtgctggag attctgccga tttcaaacct      900

tacttagagg aactcgatgt cccagcagat tccaaaaaca acaccttcat tgcaggcgaa      960

ttacagtttg atcttccacg ttgggaaggt gtgccttttt acgtgcgcag cggtaaacga     1020

ctcgcagcca aacagactcg cgtcgatatt gttttcaagg ctggcacctt taatttcggg     1080

tctgaacagg aagctcaaga ggccgttctg tccatcatca ttgatccgaa gggagcaatc     1140

gaactgaagc tcaatgcaaa atctgtggaa gatgctttca acacccgcac tatcgacttg     1200

ggctggaccg tgagcgatga ggacaagaaa aatacgccag aaccttatga aaggatgatc     1260

cacgatacga tgaacggtga cggcagcaac ttcgcagatt ggaatggcgt gagcattgcg     1320

tggaagttcg tagatgctat ttctgcggta tatacggccg ataaggcccc gcttgaaacc     1380

tacaagtcgg gctccatggg acccgaagcc agcgacaaat tgctcgccgc aaacggagat     1440

gcatgggtat tcaaggggta g                                               1461


<210>  30
<211>  486
<212>  PRT
<213>  Unknown

<220>
<223>  Mutant (R46E/Q47E) of the glucose-6-phosphate dehydrogenase of 
       Leuconoston.mesenteroides; lmZWF

<400>  30

Met Val Ser Glu Ile Lys Thr Leu Val Thr Phe Phe Gly Gly Thr Gly 
1               5                   10                  15      


Asp Leu Ala Lys Arg Lys Leu Tyr Pro Ser Val Phe Asn Leu Tyr Lys 
            20                  25                  30          


Lys Gly Tyr Leu Gln Lys His Phe Ala Ile Val Gly Thr Ala Glu Glu 
        35                  40                  45              


Ala Leu Asn Asp Asp Glu Phe Lys Gln Leu Val Arg Asp Ser Ile Lys 
    50                  55                  60                  


Asp Phe Thr Asp Asp Gln Ala Gln Ala Glu Ala Phe Ile Glu His Phe 
65                  70                  75                  80  


Ser Tyr Arg Ala His Asp Val Thr Asp Ala Ala Ser Tyr Ala Val Leu 
                85                  90                  95      


Lys Glu Ala Ile Glu Glu Ala Ala Asp Lys Phe Asp Ile Asp Gly Asn 
            100                 105                 110         


Arg Ile Phe Tyr Met Ser Val Ala Pro Arg Phe Phe Gly Thr Ile Ala 
        115                 120                 125             


Lys Tyr Leu Lys Ser Glu Gly Leu Leu Ala Asp Thr Gly Tyr Asn Arg 
    130                 135                 140                 


Leu Met Ile Glu Lys Pro Phe Gly Thr Ser Tyr Asp Thr Ala Ala Glu 
145                 150                 155                 160 


Leu Gln Asn Asp Leu Glu Asn Ala Phe Asp Asp Asn Gln Leu Phe Arg 
                165                 170                 175     


Ile Asp His Tyr Leu Gly Lys Glu Met Val Gln Asn Ile Ala Ala Leu 
            180                 185                 190         


Arg Phe Gly Asn Pro Ile Phe Asp Ala Ala Trp Asn Lys Asp Tyr Ile 
        195                 200                 205             


Lys Asn Val Gln Val Thr Leu Ser Glu Val Leu Gly Val Glu Glu Arg 
    210                 215                 220                 


Ala Gly Tyr Tyr Asp Thr Ala Gly Ala Leu Leu Asp Met Ile Gln Asn 
225                 230                 235                 240 


His Thr Met Gln Ile Val Gly Trp Leu Ala Met Glu Lys Pro Glu Ser 
                245                 250                 255     


Phe Thr Asp Lys Asp Ile Arg Ala Ala Lys Asn Ala Ala Phe Asn Ala 
            260                 265                 270         


Leu Lys Ile Tyr Asp Glu Ala Glu Val Asn Lys Tyr Phe Val Arg Ala 
        275                 280                 285             


Gln Tyr Gly Ala Gly Asp Ser Ala Asp Phe Lys Pro Tyr Leu Glu Glu 
    290                 295                 300                 


Leu Asp Val Pro Ala Asp Ser Lys Asn Asn Thr Phe Ile Ala Gly Glu 
305                 310                 315                 320 


Leu Gln Phe Asp Leu Pro Arg Trp Glu Gly Val Pro Phe Tyr Val Arg 
                325                 330                 335     


Ser Gly Lys Arg Leu Ala Ala Lys Gln Thr Arg Val Asp Ile Val Phe 
            340                 345                 350         


Lys Ala Gly Thr Phe Asn Phe Gly Ser Glu Gln Glu Ala Gln Glu Ala 
        355                 360                 365             


Val Leu Ser Ile Ile Ile Asp Pro Lys Gly Ala Ile Glu Leu Lys Leu 
    370                 375                 380                 


Asn Ala Lys Ser Val Glu Asp Ala Phe Asn Thr Arg Thr Ile Asp Leu 
385                 390                 395                 400 


Gly Trp Thr Val Ser Asp Glu Asp Lys Lys Asn Thr Pro Glu Pro Tyr 
                405                 410                 415     


Glu Arg Met Ile His Asp Thr Met Asn Gly Asp Gly Ser Asn Phe Ala 
            420                 425                 430         


Asp Trp Asn Gly Val Ser Ile Ala Trp Lys Phe Val Asp Ala Ile Ser 
        435                 440                 445             


Ala Val Tyr Thr Ala Asp Lys Ala Pro Leu Glu Thr Tyr Lys Ser Gly 
    450                 455                 460                 


Ser Met Gly Pro Glu Ala Ser Asp Lys Leu Leu Ala Ala Asn Gly Asp 
465                 470                 475                 480 


Ala Trp Val Phe Lys Gly 
                485     


<210>  31
<211>  1458
<212>  DNA
<213>  Zymomonas mobilis

<220>
<223>  Codon optimized variant of the glucose-6-phosphate dehydrogenase 
       from Zymomonas mobilis strain ATCC 10988 (Zmob_0908)

<400>  31
atgactaata ctgtttctac catgatcctt ttcggcagca ccggagatct ctcgcagcgc       60

atgcttcttc cctcgctgta cgggctggat gcagacggtc tactcgccga cgacctccgc      120

attgtgtgta cctctcgttc cgagtacgat accgacggat ttcgtgattt tgctgagaag      180

gcactggacc gtttcgttgc ctccgacaga cttaatgatg atgcaaaagc gaagttcctc      240

aacaagcttt tctacgcaac ggttgacatc accgatccaa cccaatttgg aaagctcgca      300

gacctctgcg gtccagtcga aaagggcatt gcaatctacc tttccacagc accatccttg      360

ttcgaaggcg caattgctgg cttgaaacag gcgggcctgg ccggcccgac ctcccgcctt      420

gcattggaaa agcccttggg tcaagatctt gcttcctctg atcacatcaa cgacgcagtg      480

ctgaaggttt tttccgaaaa acaagtatac cgtatcgacc actatcttgg gaaagaaacc      540

gtccagaatc tcctaacact ccgctttgga aatgcattgt tcgagccgtt gtggaactca      600

aaggggattg accacgtgca gatctccgtc gctgagacag tgggactcga aggacgcatc      660

ggctactttg acggctccgg ctccctgcga gacatggtgc agtctcacat cctgcaattg      720

gttgcccttg tagctatgga gcccccggct cacatggaag caaacgcggt ccgcgacgaa      780

aaggttaagg tgttccgtgc acttcgtccc attaacaacg acactgtttt cacacacacc      840

gtgactggcc aatacggcgc cggcgtgtcg gggggaaagg aagttgcagg ctacatcgat      900

gagcttggac aaccgagtga tactgaaacc tttgttgcaa ttaaagcaca cgtggataac      960

tggcgctggc agggagttcc cttctacatc cgcactggta aacggctccc tgcccgccgt     1020

tcagagatcg tcgttcagtt caaaccagtt ccccactcca ttttttcaag ctcaggagga     1080

atccttcagc ctaataaatt gcgcattgtc ctgcaaccag acgaaaccat ccaaatctca     1140

atgatggtca aggaaccagg tcttgacaga aatggtgcac acatgcgtga ggtctggctg     1200

gatctctctt tgaccgacgt gttcaaagat cgaaagcgcc ggattgctta cgagcgcctt     1260

atgctcgatc tgattgaggg tgacgcaacc ctcttcgtgc gccgcgacga ggtcgaggca     1320

cagtgggttt ggatcgacgg tatccgggaa ggctggaagg ctaatagcat gaagcctaaa     1380

acctatgtct ccggcacctg gggaccctcc accgctattg cattggcaga gcgcgatggc     1440

gtcacctggt acgactaa                                                   1458


<210>  32
<211>  485
<212>  PRT
<213>  Zymomonas mobilis

<220>
<223>  Codon-optimized variant of the glu6-phosphate dehydrogenase from 
       Zymomonas mobilis strain ATCC 10988 (NCBI-ProteinID: AEH62743.1)

<400>  32

Met Thr Asn Thr Val Ser Thr Met Ile Leu Phe Gly Ser Thr Gly Asp 
1               5                   10                  15      


Leu Ser Gln Arg Met Leu Leu Pro Ser Leu Tyr Gly Leu Asp Ala Asp 
            20                  25                  30          


Gly Leu Leu Ala Asp Asp Leu Arg Ile Val Cys Thr Ser Arg Ser Glu 
        35                  40                  45              


Tyr Asp Thr Asp Gly Phe Arg Asp Phe Ala Glu Lys Ala Leu Asp Arg 
    50                  55                  60                  


Phe Val Ala Ser Asp Arg Leu Asn Asp Asp Ala Lys Ala Lys Phe Leu 
65                  70                  75                  80  


Asn Lys Leu Phe Tyr Ala Thr Val Asp Ile Thr Asp Pro Thr Gln Phe 
                85                  90                  95      


Gly Lys Leu Ala Asp Leu Cys Gly Pro Val Glu Lys Gly Ile Ala Ile 
            100                 105                 110         


Tyr Leu Ser Thr Ala Pro Ser Leu Phe Glu Gly Ala Ile Ala Gly Leu 
        115                 120                 125             


Lys Gln Ala Gly Leu Ala Gly Pro Thr Ser Arg Leu Ala Leu Glu Lys 
    130                 135                 140                 


Pro Leu Gly Gln Asp Leu Ala Ser Ser Asp His Ile Asn Asp Ala Val 
145                 150                 155                 160 


Leu Lys Val Phe Ser Glu Lys Gln Val Tyr Arg Ile Asp His Tyr Leu 
                165                 170                 175     


Gly Lys Glu Thr Val Gln Asn Leu Leu Thr Leu Arg Phe Gly Asn Ala 
            180                 185                 190         


Leu Phe Glu Pro Leu Trp Asn Ser Lys Gly Ile Asp His Val Gln Ile 
        195                 200                 205             


Ser Val Ala Glu Thr Val Gly Leu Glu Gly Arg Ile Gly Tyr Phe Asp 
    210                 215                 220                 


Gly Ser Gly Ser Leu Arg Asp Met Val Gln Ser His Ile Leu Gln Leu 
225                 230                 235                 240 


Val Ala Leu Val Ala Met Glu Pro Pro Ala His Met Glu Ala Asn Ala 
                245                 250                 255     


Val Arg Asp Glu Lys Val Lys Val Phe Arg Ala Leu Arg Pro Ile Asn 
            260                 265                 270         


Asn Asp Thr Val Phe Thr His Thr Val Thr Gly Gln Tyr Gly Ala Gly 
        275                 280                 285             


Val Ser Gly Gly Lys Glu Val Ala Gly Tyr Ile Asp Glu Leu Gly Gln 
    290                 295                 300                 


Pro Ser Asp Thr Glu Thr Phe Val Ala Ile Lys Ala His Val Asp Asn 
305                 310                 315                 320 


Trp Arg Trp Gln Gly Val Pro Phe Tyr Ile Arg Thr Gly Lys Arg Leu 
                325                 330                 335     


Pro Ala Arg Arg Ser Glu Ile Val Val Gln Phe Lys Pro Val Pro His 
            340                 345                 350         


Ser Ile Phe Ser Ser Ser Gly Gly Ile Leu Gln Pro Asn Lys Leu Arg 
        355                 360                 365             


Ile Val Leu Gln Pro Asp Glu Thr Ile Gln Ile Ser Met Met Val Lys 
    370                 375                 380                 


Glu Pro Gly Leu Asp Arg Asn Gly Ala His Met Arg Glu Val Trp Leu 
385                 390                 395                 400 


Asp Leu Ser Leu Thr Asp Val Phe Lys Asp Arg Lys Arg Arg Ile Ala 
                405                 410                 415     


Tyr Glu Arg Leu Met Leu Asp Leu Ile Glu Gly Asp Ala Thr Leu Phe 
            420                 425                 430         


Val Arg Arg Asp Glu Val Glu Ala Gln Trp Val Trp Ile Asp Gly Ile 
        435                 440                 445             


Arg Glu Gly Trp Lys Ala Asn Ser Met Lys Pro Lys Thr Tyr Val Ser 
    450                 455                 460                 


Gly Thr Trp Gly Pro Ser Thr Ala Ile Ala Leu Ala Glu Arg Asp Gly 
465                 470                 475                 480 


Val Thr Trp Tyr Asp 
                485 


<210>  33
<211>  1401
<212>  DNA
<213>  Escherichia coli

<220>
<223>  Soluble Pyridine Nucleotide Transhydrogenase from Escherichia 
       coli; udhA (NP_418397.2, EG11428)

<400>  33
atgccacatt cctacgatta cgatgccata gtaataggtt ccggccccgg cggcgaaggc       60

gctgcaatgg gcctggttaa gcaaggtgcg cgcgtcgcag ttatcgagcg ttatcaaaat      120

gttggcggcg gttgcaccca ctggggcacc atcccgtcga aagctctccg tcacgccgtc      180

agccgcatta tagaattcaa tcaaaaccca ctttacagcg accattcccg actgctccgc      240

tcttcttttg ccgatatcct taaccatgcc gataacgtga ttaatcaaca aacgcgcatg      300

cgtcagggat tttacgaacg taatcactgt gaaatattgc agggaaacgc tcgctttgtt      360

gacgagcata cgttggcgct ggattgcctg gacggcagcg ttgaaacact aaccgctgaa      420

aaatttgtta ttgcctgcgg ctctcgtcca tatcatccaa cagatgttga tttcacccat      480

ccacgcattt acgacagcga ctcaattctc agcatgcacc acgaaccgcg ccatgtactt      540

atctatggtg ctggagtgat cggctgtgaa tatgcgtcga tcttccgcgg tatggatgta      600

aaagtggatc tgatcaacac ccgcgatcgc ctgctggcat ttctcgatca agagatgtca      660

gattctctct cctatcactt ctggaacagt ggcgtagtga ttcgtcacaa cgaagagtac      720

gagaagatcg aaggctgtga cgatggtgtg atcatgcatc tgaagtcggg taaaaaactg      780

aaagctgact gcctgctcta tgccaacggt cgcaccggta ataccgattc gctggcgtta      840

cagaacattg ggctagaaac tgacagccgc ggacagctga aggtcaacag catgtatcag      900

accgcacagc cacacgttta cgcggtgggc gacgtgattg gttatccgag cctggcgtcg      960

gcggcctatg accaggggcg cattgccgcg caggcgctgg taaaaggcga agccaccgca     1020

catctgattg aagatatccc taccggtatt tacaccatcc cggaaatcag ctctgtgggc     1080

aaaaccgaac agcagctgac cgcaatgaaa gtgccatatg aagtgggccg cgcccagttt     1140

aaacatctgg cacgcgcaca aatcgtcggc atgaacgtgg gcacgctgaa aattttgttc     1200

catcgggaaa caaaagagat tctgggtatt cactgctttg gcgagcgcgc tgccgaaatt     1260

attcatatcg gtcaggcgat tatggaacag aaaggtggcg gcaacactat tgagtacttc     1320

gtcaacacca cctttaacta cccgacgatg gcggaagcct atcgggtagc tgcgttaaac     1380

ggtttaaacc gcctgtttta a                                               1401


<210>  34
<211>  466
<212>  PRT
<213>  Escherichia coli

<220>
<223>  Soluble Pyridine Nucleotide Transhydrogenase from Escherichia 
       coli; udhA  (AAC76944)

<400>  34

Met Pro His Ser Tyr Asp Tyr Asp Ala Ile Val Ile Gly Ser Gly Pro 
1               5                   10                  15      


Gly Gly Glu Gly Ala Ala Met Gly Leu Val Lys Gln Gly Ala Arg Val 
            20                  25                  30          


Ala Val Ile Glu Arg Tyr Gln Asn Val Gly Gly Gly Cys Thr His Trp 
        35                  40                  45              


Gly Thr Ile Pro Ser Lys Ala Leu Arg His Ala Val Ser Arg Ile Ile 
    50                  55                  60                  


Glu Phe Asn Gln Asn Pro Leu Tyr Ser Asp His Ser Arg Leu Leu Arg 
65                  70                  75                  80  


Ser Ser Phe Ala Asp Ile Leu Asn His Ala Asp Asn Val Ile Asn Gln 
                85                  90                  95      


Gln Thr Arg Met Arg Gln Gly Phe Tyr Glu Arg Asn His Cys Glu Ile 
            100                 105                 110         


Leu Gln Gly Asn Ala Arg Phe Val Asp Glu His Thr Leu Ala Leu Asp 
        115                 120                 125             


Cys Leu Asp Gly Ser Val Glu Thr Leu Thr Ala Glu Lys Phe Val Ile 
    130                 135                 140                 


Ala Cys Gly Ser Arg Pro Tyr His Pro Thr Asp Val Asp Phe Thr His 
145                 150                 155                 160 


Pro Arg Ile Tyr Asp Ser Asp Ser Ile Leu Ser Met His His Glu Pro 
                165                 170                 175     


Arg His Val Leu Ile Tyr Gly Ala Gly Val Ile Gly Cys Glu Tyr Ala 
            180                 185                 190         


Ser Ile Phe Arg Gly Met Asp Val Lys Val Asp Leu Ile Asn Thr Arg 
        195                 200                 205             


Asp Arg Leu Leu Ala Phe Leu Asp Gln Glu Met Ser Asp Ser Leu Ser 
    210                 215                 220                 


Tyr His Phe Trp Asn Ser Gly Val Val Ile Arg His Asn Glu Glu Tyr 
225                 230                 235                 240 


Glu Lys Ile Glu Gly Cys Asp Asp Gly Val Ile Met His Leu Lys Ser 
                245                 250                 255     


Gly Lys Lys Leu Lys Ala Asp Cys Leu Leu Tyr Ala Asn Gly Arg Thr 
            260                 265                 270         


Gly Asn Thr Asp Ser Leu Ala Leu Gln Asn Ile Gly Leu Glu Thr Asp 
        275                 280                 285             


Ser Arg Gly Gln Leu Lys Val Asn Ser Met Tyr Gln Thr Ala Gln Pro 
    290                 295                 300                 


His Val Tyr Ala Val Gly Asp Val Ile Gly Tyr Pro Ser Leu Ala Ser 
305                 310                 315                 320 


Ala Ala Tyr Asp Gln Gly Arg Ile Ala Ala Gln Ala Leu Val Lys Gly 
                325                 330                 335     


Glu Ala Thr Ala His Leu Ile Glu Asp Ile Pro Thr Gly Ile Tyr Thr 
            340                 345                 350         


Ile Pro Glu Ile Ser Ser Val Gly Lys Thr Glu Gln Gln Leu Thr Ala 
        355                 360                 365             


Met Lys Val Pro Tyr Glu Val Gly Arg Ala Gln Phe Lys His Leu Ala 
    370                 375                 380                 


Arg Ala Gln Ile Val Gly Met Asn Val Gly Thr Leu Lys Ile Leu Phe 
385                 390                 395                 400 


His Arg Glu Thr Lys Glu Ile Leu Gly Ile His Cys Phe Gly Glu Arg 
                405                 410                 415     


Ala Ala Glu Ile Ile His Ile Gly Gln Ala Ile Met Glu Gln Lys Gly 
            420                 425                 430         


Gly Gly Asn Thr Ile Glu Tyr Phe Val Asn Thr Thr Phe Asn Tyr Pro 
        435                 440                 445             


Thr Met Ala Glu Ala Tyr Arg Val Ala Ala Leu Asn Gly Leu Asn Arg 
    450                 455                 460                 


Leu Phe 
465     


<210>  35
<211>  1401
<212>  DNA
<213>  Escherichia coli

<220>
<223>  "A" subunit of  Membrane bound Pyridine Nucleotide 
       Transhydrogenase (pnt) from Escherichia coli  MG1655; ECK1598 
       (variant g1342a, NP_416120.1)

<400>  35
atgccacatt cctacgatta cgatgccata gtaataggtt ccggccccgg cggcgaaggc       60

gctgcaatgg gcctggttaa gcaaggtgcg cgcgtcgcag ttatcgagcg ttatcaaaat      120

gttggcggcg gttgcaccca ctggggcacc atcccgtcga aagctctccg tcacgccgtc      180

agccgcatta tagaattcaa tcaaaaccca ctttacagcg accattcccg actgctccgc      240

tcttcttttg ccgatatcct taaccatgcc gataacgtga ttaatcaaca aacgcgcatg      300

cgtcagggat tttacgaacg taatcactgt gaaatattgc agggaaacgc tcgctttgtt      360

gacgagcata cgttggcgct ggattgcctg gacggcagcg ttgaaacact aaccgctgaa      420

aaatttgtta ttgcctgcgg ctctcgtcca tatcatccaa cagatgttga tttcacccat      480

ccacgcattt acgacagcga ctcaattctc agcatgcacc acgaaccgcg ccatgtactt      540

atctatggtg ctggagtgat cggctgtgaa tatgcgtcga tcttccgcgg tatggatgta      600

aaagtggatc tgatcaacac ccgcgatcgc ctgctggcat ttctcgatca agagatgtca      660

gattctctct cctatcactt ctggaacagt ggcgtagtga ttcgtcacaa cgaagagtac      720

gagaagatcg aaggctgtga cgatggtgtg atcatgcatc tgaagtcggg taaaaaactg      780

aaagctgact gcctgctcta tgccaacggt cgcaccggta ataccgattc gctggcgtta      840

cagaacattg ggctagaaac tgacagccgc ggacagctga aggtcaacag catgtatcag      900

accgcacagc cacacgttta cgcggtgggc gacgtgattg gttatccgag cctggcgtcg      960

gcggcctatg accaggggcg cattgccgcg caggcgctgg taaaaggcga agccaccgca     1020

catctgattg aagatatccc taccggtatt tacaccatcc cggaaatcag ctctgtgggc     1080

aaaaccgaac agcagctgac cgcaatgaaa gtgccatatg aagtgggccg cgcccagttt     1140

aaacatctgg cacgcgcaca aatcgtcggc atgaacgtgg gcacgctgaa aattttgttc     1200

catcgggaaa caaaagagat tctgggtatt cactgctttg gcgagcgcgc tgccgaaatt     1260

attcatatcg gtcaggcgat tatggaacag aaaggtggcg gcaacactat tgagtacttc     1320

gtcaacacca cctttaacta cccgacgatg gcggaagcct atcgggtagc tgcgttaaac     1380

ggtttaaacc gcctgtttta a                                               1401


<210>  36
<211>  510
<212>  PRT
<213>  Escherichia coli

<220>
<223>  "A" subunit of  Membrane bound Pyridine Nucleotide 
       Transhydrogenase (pnt) from Escherichia coli; P07001.2  (A434T 
       variant)

<400>  36

Met Arg Ile Gly Ile Pro Arg Glu Arg Leu Thr Asn Glu Thr Arg Val 
1               5                   10                  15      


Ala Ala Thr Pro Lys Thr Val Glu Gln Leu Leu Lys Leu Gly Phe Thr 
            20                  25                  30          


Val Ala Val Glu Ser Gly Ala Gly Gln Leu Ala Ser Phe Asp Asp Lys 
        35                  40                  45              


Ala Phe Val Gln Ala Gly Ala Glu Ile Val Glu Gly Asn Ser Val Trp 
    50                  55                  60                  


Gln Ser Glu Ile Ile Leu Lys Val Asn Ala Pro Leu Asp Asp Glu Ile 
65                  70                  75                  80  


Ala Leu Leu Asn Pro Gly Thr Thr Leu Val Ser Phe Ile Trp Pro Ala 
                85                  90                  95      


Gln Asn Pro Glu Leu Met Gln Lys Leu Ala Glu Arg Asn Val Thr Val 
            100                 105                 110         


Met Ala Met Asp Ser Val Pro Arg Ile Ser Arg Ala Gln Ser Leu Asp 
        115                 120                 125             


Ala Leu Ser Ser Met Ala Asn Ile Ala Gly Tyr Arg Ala Ile Val Glu 
    130                 135                 140                 


Ala Ala His Glu Phe Gly Arg Phe Phe Thr Gly Gln Ile Thr Ala Ala 
145                 150                 155                 160 


Gly Lys Val Pro Pro Ala Lys Val Met Val Ile Gly Ala Gly Val Ala 
                165                 170                 175     


Gly Leu Ala Ala Ile Gly Ala Ala Asn Ser Leu Gly Ala Ile Val Arg 
            180                 185                 190         


Ala Phe Asp Thr Arg Pro Glu Val Lys Glu Gln Val Gln Ser Met Gly 
        195                 200                 205             


Ala Glu Phe Leu Glu Leu Asp Phe Lys Glu Glu Ala Gly Ser Gly Asp 
    210                 215                 220                 


Gly Tyr Ala Lys Val Met Ser Asp Ala Phe Ile Lys Ala Glu Met Glu 
225                 230                 235                 240 


Leu Phe Ala Ala Gln Ala Lys Glu Val Asp Ile Ile Val Thr Thr Ala 
                245                 250                 255     


Leu Ile Pro Gly Lys Pro Ala Pro Lys Leu Ile Thr Arg Glu Met Val 
            260                 265                 270         


Asp Ser Met Lys Ala Gly Ser Val Ile Val Asp Leu Ala Ala Gln Asn 
        275                 280                 285             


Gly Gly Asn Cys Glu Tyr Thr Val Pro Gly Glu Ile Phe Thr Thr Glu 
    290                 295                 300                 


Asn Gly Val Lys Val Ile Gly Tyr Thr Asp Leu Pro Gly Arg Leu Pro 
305                 310                 315                 320 


Thr Gln Ser Ser Gln Leu Tyr Gly Thr Asn Leu Val Asn Leu Leu Lys 
                325                 330                 335     


Leu Leu Cys Lys Glu Lys Asp Gly Asn Ile Thr Val Asp Phe Asp Asp 
            340                 345                 350         


Val Val Ile Arg Gly Val Thr Val Ile Arg Ala Gly Glu Ile Thr Trp 
        355                 360                 365             


Pro Ala Pro Pro Ile Gln Val Ser Ala Gln Pro Gln Ala Ala Gln Lys 
    370                 375                 380                 


Ala Ala Pro Glu Val Lys Thr Glu Glu Lys Cys Thr Cys Ser Pro Trp 
385                 390                 395                 400 


Arg Lys Tyr Ala Leu Met Ala Leu Ala Ile Ile Leu Phe Gly Trp Met 
                405                 410                 415     


Ala Ser Val Ala Pro Lys Glu Phe Leu Gly His Phe Thr Val Phe Ala 
            420                 425                 430         


Leu Thr Cys Val Val Gly Tyr Tyr Val Val Trp Asn Val Ser His Ala 
        435                 440                 445             


Leu His Thr Pro Leu Met Ser Val Thr Asn Ala Ile Ser Gly Ile Ile 
    450                 455                 460                 


Val Val Gly Ala Leu Leu Gln Ile Gly Gln Gly Gly Trp Val Ser Phe 
465                 470                 475                 480 


Leu Ser Phe Ile Ala Val Leu Ile Ala Ser Ile Asn Ile Phe Gly Gly 
                485                 490                 495     


Phe Thr Val Thr Gln Arg Met Leu Lys Met Phe Arg Lys Asn 
            500                 505                 510 


<210>  37
<211>  1389
<212>  DNA
<213>  Escherichia coli

<220>
<223>  "B" subunit of  Membrane bound Pyridine Nucleotide 
       Transhydrogenase (pntB) from Escherichia coli  (MG1655; ECK1597; 
       NP_416119.1)

<400>  37
atgtctggag gattagttac agctgcatac attgttgccg cgatcctgtt tatcttcagt       60

ctggccggtc tttcgaaaca tgaaacgtct cgccagggta acaacttcgg tatcgccggg      120

atggcgattg cgttaatcgc aaccattttt ggaccggata cgggtaatgt tggctggatc      180

ttgctggcga tggtcattgg tggggcaatt ggtatccgtc tggcgaagaa agttgaaatg      240

accgaaatgc cagaactggt ggcgatcctg catagcttcg tgggtctggc ggcagtgctg      300

gttggcttta acagctatct gcatcatgac gcgggaatgg caccgattct ggtcaatatt      360

cacctgacgg aagtgttcct cggtatcttc atcggggcgg taacgttcac gggttcggtg      420

gtggcgttcg gcaaactgtg tggcaagatt tcgtctaaac cattgatgct gccaaaccgt      480

cacaaaatga acctggcggc tctggtcgtt tccttcctgc tgctgattgt atttgttcgc      540

acggacagcg tcggcctgca agtgctggca ttgctgataa tgaccgcaat tgcgctggta      600

ttcggctggc atttagtcgc ctccatcggt ggtgcagata tgccagtggt ggtgtcgatg      660

ctgaactcgt actccggctg ggcggctgcg gctgcgggct ttatgctcag caacgacctg      720

ctgattgtga ccggtgcgct ggtcggttct tcgggggcta tcctttctta cattatgtgt      780

aaggcgatga accgttcctt tatcagcgtt attgcgggtg gtttcggcac cgacggctct      840

tctactggcg atgatcagga agtgggtgag caccgcgaaa tcaccgcaga agagacagcg      900

gaactgctga aaaactccca ttcagtgatc attactccgg ggtacggcat ggcagtcgcg      960

caggcgcaat atcctgtcgc tgaaattact gagaaattgc gcgctcgtgg tattaatgtg     1020

cgtttcggta tccacccggt cgcggggcgt ttgcctggac atatgaacgt attgctggct     1080

gaagcaaaag taccgtatga catcgtgctg gaaatggacg agatcaatga tgactttgct     1140

gataccgata ccgtactggt gattggtgct aacgatacgg ttaacccggc ggcgcaggat     1200

gatccgaaga gtccgattgc tggtatgcct gtgctggaag tgtggaaagc gcagaacgtg     1260

attgtcttta aacgttcgat gaacactggc tatgctggtg tgcaaaaccc gctgttcttc     1320

aaggaaaaca cccacatgct gtttggtgac gccaaagcca gcgtggatgc aatcctgaaa     1380

gctctgtaa                                                             1389


<210>  38
<211>  462
<212>  PRT
<213>  Escherichia coli

<220>
<223>  "B" subunit of  Membrane bound Pyridine Nucleotide 
       Transhydrogenase (pntB) from Escherichia coli; P0AB69.1

<400>  38

Met Ser Gly Gly Leu Val Thr Ala Ala Tyr Ile Val Ala Ala Ile Leu 
1               5                   10                  15      


Phe Ile Phe Ser Leu Ala Gly Leu Ser Lys His Glu Thr Ser Arg Gln 
            20                  25                  30          


Gly Asn Asn Phe Gly Ile Ala Gly Met Ala Ile Ala Leu Ile Ala Thr 
        35                  40                  45              


Ile Phe Gly Pro Asp Thr Gly Asn Val Gly Trp Ile Leu Leu Ala Met 
    50                  55                  60                  


Val Ile Gly Gly Ala Ile Gly Ile Arg Leu Ala Lys Lys Val Glu Met 
65                  70                  75                  80  


Thr Glu Met Pro Glu Leu Val Ala Ile Leu His Ser Phe Val Gly Leu 
                85                  90                  95      


Ala Ala Val Leu Val Gly Phe Asn Ser Tyr Leu His His Asp Ala Gly 
            100                 105                 110         


Met Ala Pro Ile Leu Val Asn Ile His Leu Thr Glu Val Phe Leu Gly 
        115                 120                 125             


Ile Phe Ile Gly Ala Val Thr Phe Thr Gly Ser Val Val Ala Phe Gly 
    130                 135                 140                 


Lys Leu Cys Gly Lys Ile Ser Ser Lys Pro Leu Met Leu Pro Asn Arg 
145                 150                 155                 160 


His Lys Met Asn Leu Ala Ala Leu Val Val Ser Phe Leu Leu Leu Ile 
                165                 170                 175     


Val Phe Val Arg Thr Asp Ser Val Gly Leu Gln Val Leu Ala Leu Leu 
            180                 185                 190         


Ile Met Thr Ala Ile Ala Leu Val Phe Gly Trp His Leu Val Ala Ser 
        195                 200                 205             


Ile Gly Gly Ala Asp Met Pro Val Val Val Ser Met Leu Asn Ser Tyr 
    210                 215                 220                 


Ser Gly Trp Ala Ala Ala Ala Ala Gly Phe Met Leu Ser Asn Asp Leu 
225                 230                 235                 240 


Leu Ile Val Thr Gly Ala Leu Val Gly Ser Ser Gly Ala Ile Leu Ser 
                245                 250                 255     


Tyr Ile Met Cys Lys Ala Met Asn Arg Ser Phe Ile Ser Val Ile Ala 
            260                 265                 270         


Gly Gly Phe Gly Thr Asp Gly Ser Ser Thr Gly Asp Asp Gln Glu Val 
        275                 280                 285             


Gly Glu His Arg Glu Ile Thr Ala Glu Glu Thr Ala Glu Leu Leu Lys 
    290                 295                 300                 


Asn Ser His Ser Val Ile Ile Thr Pro Gly Tyr Gly Met Ala Val Ala 
305                 310                 315                 320 


Gln Ala Gln Tyr Pro Val Ala Glu Ile Thr Glu Lys Leu Arg Ala Arg 
                325                 330                 335     


Gly Ile Asn Val Arg Phe Gly Ile His Pro Val Ala Gly Arg Leu Pro 
            340                 345                 350         


Gly His Met Asn Val Leu Leu Ala Glu Ala Lys Val Pro Tyr Asp Ile 
        355                 360                 365             


Val Leu Glu Met Asp Glu Ile Asn Asp Asp Phe Ala Asp Thr Asp Thr 
    370                 375                 380                 


Val Leu Val Ile Gly Ala Asn Asp Thr Val Asn Pro Ala Ala Gln Asp 
385                 390                 395                 400 


Asp Pro Lys Ser Pro Ile Ala Gly Met Pro Val Leu Glu Val Trp Lys 
                405                 410                 415     


Ala Gln Asn Val Ile Val Phe Lys Arg Ser Met Asn Thr Gly Tyr Ala 
            420                 425                 430         


Gly Val Gln Asn Pro Leu Phe Phe Lys Glu Asn Thr His Met Leu Phe 
        435                 440                 445             


Gly Asp Ala Lys Ala Ser Val Asp Ala Ile Leu Lys Ala Leu 
    450                 455                 460         


