                               SEQUENCE LISTING

<110> SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
 
<120> METHODS AND COMPOSITIONS FOR INDUCTION OF ANTITUMOR IMMUNITY

<130> 42256-747.601

<140> PCT/US2021/030478
<141> 2021-05-03

<150> 63/019,914
<151> 2020-05-04

<160> 34    

<170> PatentIn version 3.5

<210> 1
<211> 1866
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Pro Val Gly Leu Gln Leu Gly Asn Lys Asn Leu Trp Ser Cys 
1               5                   10                  15      


Leu Val Arg Leu Leu Thr Lys Asp Pro Glu Trp Leu Asn Ala Lys Met 
            20                  25                  30          


Lys Phe Phe Leu Pro Asn Thr Asp Leu Asp Ser Arg Asn Glu Thr Leu 
        35                  40                  45              


Asp Pro Glu Gln Arg Val Ile Leu Gln Leu Asn Lys Leu His Val Gln 
    50                  55                  60                  


Gly Ser Asp Thr Trp Gln Ser Phe Ile His Cys Val Cys Met Gln Leu 
65                  70                  75                  80  


Glu Val Pro Leu Asp Leu Glu Val Leu Leu Leu Ser Thr Phe Gly Tyr 
                85                  90                  95      


Asp Asp Gly Phe Thr Ser Gln Leu Gly Ala Glu Gly Lys Ser Gln Pro 
            100                 105                 110         


Glu Ser Gln Leu His His Gly Leu Lys Arg Pro His Gln Ser Cys Gly 
        115                 120                 125             


Ser Ser Pro Arg Arg Lys Gln Cys Lys Lys Gln Gln Leu Glu Leu Ala 
    130                 135                 140                 


Lys Lys Tyr Leu Gln Leu Leu Arg Thr Ser Ala Gln Gln Arg Tyr Arg 
145                 150                 155                 160 


Ser Gln Ile Pro Gly Ser Gly Gln Pro His Ala Phe His Gln Val Tyr 
                165                 170                 175     


Val Pro Pro Ile Leu Arg Arg Ala Thr Ala Ser Leu Asp Thr Pro Glu 
            180                 185                 190         


Gly Ala Ile Met Gly Asp Val Lys Val Glu Asp Gly Ala Asp Val Ser 
        195                 200                 205             


Ile Ser Asp Leu Phe Asn Thr Arg Val Asn Lys Gly Pro Arg Val Thr 
    210                 215                 220                 


Val Leu Leu Gly Lys Ala Gly Met Gly Lys Thr Thr Leu Ala His Arg 
225                 230                 235                 240 


Leu Cys Gln Lys Trp Ala Glu Gly His Leu Asn Cys Phe Gln Ala Leu 
                245                 250                 255     


Phe Leu Phe Glu Phe Arg Gln Leu Asn Leu Ile Thr Arg Phe Leu Thr 
            260                 265                 270         


Pro Ser Glu Leu Leu Phe Asp Leu Tyr Leu Ser Pro Glu Ser Asp His 
        275                 280                 285             


Asp Thr Val Phe Gln Tyr Leu Glu Lys Asn Ala Asp Gln Val Leu Leu 
    290                 295                 300                 


Ile Phe Asp Gly Leu Asp Glu Ala Leu Gln Pro Met Gly Pro Asp Gly 
305                 310                 315                 320 


Pro Gly Pro Val Leu Thr Leu Phe Ser His Leu Cys Asn Gly Thr Leu 
                325                 330                 335     


Leu Pro Gly Cys Arg Val Met Ala Thr Ser Arg Pro Gly Lys Leu Pro 
            340                 345                 350         


Ala Cys Leu Pro Ala Glu Ala Ala Met Val His Met Leu Gly Phe Asp 
        355                 360                 365             


Gly Pro Arg Val Glu Glu Tyr Val Asn His Phe Phe Ser Ala Gln Pro 
    370                 375                 380                 


Ser Arg Glu Gly Ala Leu Val Glu Leu Gln Thr Asn Gly Arg Leu Arg 
385                 390                 395                 400 


Ser Leu Cys Ala Val Pro Ala Leu Cys Gln Val Ala Cys Leu Cys Leu 
                405                 410                 415     


His His Leu Leu Pro Asp His Ala Pro Gly Gln Ser Val Ala Leu Leu 
            420                 425                 430         


Pro Asn Met Thr Gln Leu Tyr Met Gln Met Val Leu Ala Leu Ser Pro 
        435                 440                 445             


Pro Gly His Leu Pro Thr Ser Ser Leu Leu Asp Leu Gly Glu Val Ala 
    450                 455                 460                 


Leu Arg Gly Leu Glu Thr Gly Lys Val Ile Phe Tyr Ala Lys Asp Ile 
465                 470                 475                 480 


Ala Pro Pro Leu Ile Ala Phe Gly Ala Thr His Ser Leu Leu Thr Ser 
                485                 490                 495     


Phe Cys Val Cys Thr Gly Pro Gly His Gln Gln Thr Gly Tyr Ala Phe 
            500                 505                 510         


Thr His Leu Ser Leu Gln Glu Phe Leu Ala Ala Leu His Leu Met Ala 
        515                 520                 525             


Ser Pro Lys Val Asn Lys Asp Thr Leu Thr Gln Tyr Val Thr Leu His 
    530                 535                 540                 


Ser Arg Trp Val Gln Arg Thr Lys Ala Arg Leu Gly Leu Ser Asp His 
545                 550                 555                 560 


Leu Pro Thr Phe Leu Ala Gly Leu Ala Ser Cys Thr Cys Arg Pro Phe 
                565                 570                 575     


Leu Ser His Leu Ala Gln Gly Asn Glu Asp Cys Val Gly Ala Lys Gln 
            580                 585                 590         


Ala Ala Val Val Gln Val Leu Lys Lys Leu Ala Thr Arg Lys Leu Thr 
        595                 600                 605             


Gly Pro Lys Val Val Glu Leu Cys His Cys Val Asp Glu Thr Gln Glu 
    610                 615                 620                 


Pro Glu Leu Ala Ser Leu Thr Ala Gln Ser Leu Pro Tyr Gln Leu Pro 
625                 630                 635                 640 


Phe His Asn Phe Pro Leu Thr Cys Thr Asp Leu Ala Thr Leu Thr Asn 
                645                 650                 655     


Ile Leu Glu His Arg Glu Ala Pro Ile His Leu Asp Phe Asp Gly Cys 
            660                 665                 670         


Pro Leu Glu Pro His Cys Pro Glu Ala Leu Val Gly Cys Gly Gln Ile 
        675                 680                 685             


Glu Asn Leu Ser Phe Lys Ser Arg Lys Cys Gly Asp Ala Phe Ala Glu 
    690                 695                 700                 


Ala Leu Ser Arg Ser Leu Pro Thr Met Gly Arg Leu Gln Met Leu Gly 
705                 710                 715                 720 


Leu Ala Gly Ser Lys Ile Thr Ala Arg Gly Ile Ser His Leu Val Lys 
                725                 730                 735     


Ala Leu Pro Leu Cys Pro Gln Leu Lys Glu Val Ser Phe Arg Asp Asn 
            740                 745                 750         


Gln Leu Ser Asp Gln Val Val Leu Asn Ile Val Glu Val Leu Pro His 
        755                 760                 765             


Leu Pro Arg Leu Arg Lys Leu Asp Leu Ser Ser Asn Ser Ile Cys Val 
    770                 775                 780                 


Ser Thr Leu Leu Cys Leu Ala Arg Val Ala Val Thr Cys Pro Thr Val 
785                 790                 795                 800 


Arg Met Leu Gln Ala Arg Glu Ala Asp Leu Ile Phe Leu Leu Ser Pro 
                805                 810                 815     


Pro Thr Glu Thr Thr Ala Glu Leu Gln Arg Ala Pro Asp Leu Gln Glu 
            820                 825                 830         


Ser Asp Gly Gln Arg Lys Gly Ala Gln Ser Arg Ser Leu Thr Leu Arg 
        835                 840                 845             


Leu Gln Lys Cys Gln Leu Gln Val His Asp Ala Glu Ala Leu Ile Ala 
    850                 855                 860                 


Leu Leu Gln Glu Gly Pro His Leu Glu Glu Val Asp Leu Ser Gly Asn 
865                 870                 875                 880 


Gln Leu Glu Asp Glu Gly Cys Arg Leu Met Ala Glu Ala Ala Ser Gln 
                885                 890                 895     


Leu His Ile Ala Arg Lys Leu Asp Leu Ser Asn Asn Gly Leu Ser Val 
            900                 905                 910         


Ala Gly Val His Cys Val Leu Arg Ala Val Ser Ala Cys Trp Thr Leu 
        915                 920                 925             


Ala Glu Leu His Ile Ser Leu Gln His Lys Thr Val Ile Phe Met Phe 
    930                 935                 940                 


Ala Gln Glu Pro Glu Glu Gln Lys Gly Pro Gln Glu Arg Ala Ala Phe 
945                 950                 955                 960 


Leu Asp Ser Leu Met Leu Gln Met Pro Ser Glu Leu Pro Leu Ser Ser 
                965                 970                 975     


Arg Arg Met Arg Leu Thr His Cys Gly Leu Gln Glu Lys His Leu Glu 
            980                 985                 990         


Gln Leu Cys Lys Ala Leu Gly Gly  Ser Cys His Leu Gly  His Leu His 
        995                 1000                 1005             


Leu Asp  Phe Ser Gly Asn Ala  Leu Gly Asp Glu Gly  Ala Ala Arg 
    1010                 1015                 1020             


Leu Ala  Gln Leu Leu Pro Gly  Leu Gly Ala Leu Gln  Ser Leu Asn 
    1025                 1030                 1035             


Leu Ser  Glu Asn Gly Leu Ser  Leu Asp Ala Val Leu  Gly Leu Val 
    1040                 1045                 1050             


Arg Cys  Phe Ser Thr Leu Gln  Trp Leu Phe Arg Leu  Asp Ile Ser 
    1055                 1060                 1065             


Phe Glu  Ser Gln His Ile Leu  Leu Arg Gly Asp Lys  Thr Ser Arg 
    1070                 1075                 1080             


Asp Met  Trp Ala Thr Gly Ser  Leu Pro Asp Phe Pro  Ala Ala Ala 
    1085                 1090                 1095             


Lys Phe  Leu Gly Phe Arg Gln  Arg Cys Ile Pro Arg  Ser Leu Cys 
    1100                 1105                 1110             


Leu Ser  Glu Cys Pro Leu Glu  Pro Pro Ser Leu Thr  Arg Leu Cys 
    1115                 1120                 1125             


Ala Thr  Leu Lys Asp Cys Pro  Gly Pro Leu Glu Leu  Gln Leu Ser 
    1130                 1135                 1140             


Cys Glu  Phe Leu Ser Asp Gln  Ser Leu Glu Thr Leu  Leu Asp Cys 
    1145                 1150                 1155             


Leu Pro  Gln Leu Pro Gln Leu  Ser Leu Leu Gln Leu  Ser Gln Thr 
    1160                 1165                 1170             


Gly Leu  Ser Pro Lys Ser Pro  Phe Leu Leu Ala Asn  Thr Leu Ser 
    1175                 1180                 1185             


Leu Cys  Pro Arg Val Lys Lys  Val Asp Leu Arg Ser  Leu His His 
    1190                 1195                 1200             


Ala Thr  Leu His Phe Arg Ser  Asn Glu Glu Glu Glu  Gly Val Cys 
    1205                 1210                 1215             


Cys Gly  Arg Phe Thr Gly Cys  Ser Leu Ser Gln Glu  His Val Glu 
    1220                 1225                 1230             


Ser Leu  Cys Trp Leu Leu Ser  Lys Cys Lys Asp Leu  Ser Gln Val 
    1235                 1240                 1245             


Asp Leu  Ser Ala Asn Leu Leu  Gly Asp Ser Gly Leu  Arg Cys Leu 
    1250                 1255                 1260             


Leu Glu  Cys Leu Pro Gln Val  Pro Ile Ser Gly Leu  Leu Asp Leu 
    1265                 1270                 1275             


Ser His  Asn Ser Ile Ser Gln  Glu Ser Ala Leu Tyr  Leu Leu Glu 
    1280                 1285                 1290             


Thr Leu  Pro Ser Cys Pro Arg  Val Arg Glu Ala Ser  Val Asn Leu 
    1295                 1300                 1305             


Gly Ser  Glu Gln Ser Phe Arg  Ile His Phe Ser Arg  Glu Asp Gln 
    1310                 1315                 1320             


Ala Gly  Lys Thr Leu Arg Leu  Ser Glu Cys Ser Phe  Arg Pro Glu 
    1325                 1330                 1335             


His Val  Ser Arg Leu Ala Thr  Gly Leu Ser Lys Ser  Leu Gln Leu 
    1340                 1345                 1350             


Thr Glu  Leu Thr Leu Thr Gln  Cys Cys Leu Gly Gln  Lys Gln Leu 
    1355                 1360                 1365             


Ala Ile  Leu Leu Ser Leu Val  Gly Arg Pro Ala Gly  Leu Phe Ser 
    1370                 1375                 1380             


Leu Arg  Val Gln Glu Pro Trp  Ala Asp Arg Ala Arg  Val Leu Ser 
    1385                 1390                 1395             


Leu Leu  Glu Val Cys Ala Gln  Ala Ser Gly Ser Val  Thr Glu Ile 
    1400                 1405                 1410             


Ser Ile  Ser Glu Thr Gln Gln  Gln Leu Cys Val Gln  Leu Glu Phe 
    1415                 1420                 1425             


Pro Arg  Gln Glu Glu Asn Pro  Glu Ala Val Ala Leu  Arg Leu Ala 
    1430                 1435                 1440             


His Cys  Asp Leu Gly Ala His  His Ser Leu Leu Val  Gly Gln Leu 
    1445                 1450                 1455             


Met Glu  Thr Cys Ala Arg Leu  Gln Gln Leu Ser Leu  Ser Gln Val 
    1460                 1465                 1470             


Asn Leu  Cys Glu Asp Asp Asp  Ala Ser Ser Leu Leu  Leu Gln Ser 
    1475                 1480                 1485             


Leu Leu  Leu Ser Leu Ser Glu  Leu Lys Thr Phe Arg  Leu Thr Ser 
    1490                 1495                 1500             


Ser Cys  Val Ser Thr Glu Gly  Leu Ala His Leu Ala  Ser Gly Leu 
    1505                 1510                 1515             


Gly His  Cys His His Leu Glu  Glu Leu Asp Leu Ser  Asn Asn Gln 
    1520                 1525                 1530             


Phe Asp  Glu Glu Gly Thr Lys  Ala Leu Met Arg Ala  Leu Glu Gly 
    1535                 1540                 1545             


Lys Trp  Met Leu Lys Arg Leu  Asp Leu Ser His Leu  Leu Leu Asn 
    1550                 1555                 1560             


Ser Ser  Thr Leu Ala Leu Leu  Thr His Arg Leu Ser  Gln Met Thr 
    1565                 1570                 1575             


Cys Leu  Gln Ser Leu Arg Leu  Asn Arg Asn Ser Ile  Gly Asp Val 
    1580                 1585                 1590             


Gly Cys  Cys His Leu Ser Glu  Ala Leu Arg Ala Ala  Thr Ser Leu 
    1595                 1600                 1605             


Glu Glu  Leu Asp Leu Ser His  Asn Gln Ile Gly Asp  Ala Gly Val 
    1610                 1615                 1620             


Gln His  Leu Ala Thr Ile Leu  Pro Gly Leu Pro Glu  Leu Arg Lys 
    1625                 1630                 1635             


Ile Asp  Leu Ser Gly Asn Ser  Ile Ser Ser Ala Gly  Gly Val Gln 
    1640                 1645                 1650             


Leu Ala  Glu Ser Leu Val Leu  Cys Arg Arg Leu Glu  Glu Leu Met 
    1655                 1660                 1665             


Leu Gly  Cys Asn Ala Leu Gly  Asp Pro Thr Ala Leu  Gly Leu Ala 
    1670                 1675                 1680             


Gln Glu  Leu Pro Gln His Leu  Arg Val Leu His Leu  Pro Phe Ser 
    1685                 1690                 1695             


His Leu  Gly Pro Gly Gly Ala  Leu Ser Leu Ala Gln  Ala Leu Asp 
    1700                 1705                 1710             


Gly Ser  Pro His Leu Glu Glu  Ile Ser Leu Ala Glu  Asn Asn Leu 
    1715                 1720                 1725             


Ala Gly  Gly Val Leu Arg Phe  Cys Met Glu Leu Pro  Leu Leu Arg 
    1730                 1735                 1740             


Gln Ile  Asp Leu Val Ser Cys  Lys Ile Asp Asn Gln  Thr Ala Lys 
    1745                 1750                 1755             


Leu Leu  Thr Ser Ser Phe Thr  Ser Cys Pro Ala Leu  Glu Val Ile 
    1760                 1765                 1770             


Leu Leu  Ser Trp Asn Leu Leu  Gly Asp Glu Ala Ala  Ala Glu Leu 
    1775                 1780                 1785             


Ala Gln  Val Leu Pro Gln Met  Gly Arg Leu Lys Arg  Val Asp Leu 
    1790                 1795                 1800             


Glu Lys  Asn Gln Ile Thr Ala  Leu Gly Ala Trp Leu  Leu Ala Glu 
    1805                 1810                 1815             


Gly Leu  Ala Gln Gly Ser Ser  Ile Gln Val Ile Arg  Leu Trp Asn 
    1820                 1825                 1830             


Asn Pro  Ile Pro Cys Asp Met  Ala Gln His Leu Lys  Ser Gln Glu 
    1835                 1840                 1845             


Pro Arg  Leu Asp Phe Ala Phe  Phe Asp Asn Gln Pro  Gln Ala Pro 
    1850                 1855                 1860             


Trp Gly  Thr 
    1865     


<210> 2
<211> 785
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Lys Lys Tyr Lys Asn Ile Val Leu Leu Lys Gly Leu Glu Val 
1               5                   10                  15      


Ile Asn Asp Tyr His Phe Arg Met Val Lys Ser Leu Leu Ser Asn Asp 
            20                  25                  30          


Leu Lys Leu Asn Leu Lys Met Arg Glu Glu Tyr Asp Lys Ile Gln Ile 
        35                  40                  45              


Ala Asp Leu Met Glu Glu Lys Phe Arg Gly Asp Ala Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Lys Ile Phe Glu Asp Ile Pro Thr Leu Glu Asp Leu Ala Glu 
65                  70                  75                  80  


Thr Leu Lys Lys Glu Lys Leu Lys Val Lys Gly Pro Ala Leu Ser Arg 
                85                  90                  95      


Lys Arg Lys Lys Glu Val Asp Ala Thr Ser Pro Ala Pro Ser Thr Ser 
            100                 105                 110         


Ser Thr Val Lys Thr Glu Gly Ala Glu Ala Thr Pro Gly Ala Gln Lys 
        115                 120                 125             


Arg Lys Lys Ser Thr Lys Glu Lys Ala Gly Pro Lys Gly Ser Lys Val 
    130                 135                 140                 


Ser Glu Glu Gln Thr Gln Pro Pro Ser Pro Ala Gly Ala Gly Met Ser 
145                 150                 155                 160 


Thr Ala Met Gly Arg Ser Pro Ser Pro Lys Thr Ser Leu Ser Ala Pro 
                165                 170                 175     


Pro Asn Ser Ser Ser Thr Glu Asn Pro Lys Thr Val Ala Lys Cys Gln 
            180                 185                 190         


Val Thr Pro Arg Arg Asn Val Leu Gln Lys Arg Pro Val Ile Val Lys 
        195                 200                 205             


Val Leu Ser Thr Thr Lys Pro Phe Glu Tyr Glu Thr Pro Glu Met Glu 
    210                 215                 220                 


Lys Lys Ile Met Phe His Ala Thr Val Ala Thr Gln Thr Gln Phe Phe 
225                 230                 235                 240 


His Val Lys Val Leu Asn Thr Ser Leu Lys Glu Lys Phe Asn Gly Lys 
                245                 250                 255     


Lys Ile Ile Ile Ile Ser Asp Tyr Leu Glu Tyr Asp Ser Leu Leu Glu 
            260                 265                 270         


Val Asn Glu Glu Ser Thr Val Ser Glu Ala Gly Pro Asn Gln Thr Phe 
        275                 280                 285             


Glu Val Pro Asn Lys Ile Ile Asn Arg Ala Lys Glu Thr Leu Lys Ile 
    290                 295                 300                 


Asp Ile Leu His Lys Gln Ala Ser Gly Asn Ile Val Tyr Gly Val Phe 
305                 310                 315                 320 


Met Leu His Lys Lys Thr Val Asn Gln Lys Thr Thr Ile Tyr Glu Ile 
                325                 330                 335     


Gln Asp Asp Arg Gly Lys Met Asp Val Val Gly Thr Gly Gln Cys His 
            340                 345                 350         


Asn Ile Pro Cys Glu Glu Gly Asp Lys Leu Gln Leu Phe Cys Phe Arg 
        355                 360                 365             


Leu Arg Lys Lys Asn Gln Met Ser Lys Leu Ile Ser Glu Met His Ser 
    370                 375                 380                 


Phe Ile Gln Ile Lys Lys Lys Thr Asn Pro Arg Asn Asn Asp Pro Lys 
385                 390                 395                 400 


Ser Met Lys Leu Pro Gln Glu Gln Arg Gln Leu Pro Tyr Pro Ser Glu 
                405                 410                 415     


Ala Ser Thr Thr Phe Pro Glu Ser His Leu Arg Thr Pro Gln Met Pro 
            420                 425                 430         


Pro Thr Thr Pro Ser Ser Ser Phe Phe Thr Lys Lys Ser Glu Asp Thr 
        435                 440                 445             


Ile Ser Lys Met Asn Asp Phe Met Arg Met Gln Ile Leu Lys Glu Gly 
    450                 455                 460                 


Ser His Phe Pro Gly Pro Phe Met Thr Ser Ile Gly Pro Ala Glu Ser 
465                 470                 475                 480 


His Pro His Thr Pro Gln Met Pro Pro Ser Thr Pro Ser Ser Ser Phe 
                485                 490                 495     


Leu Thr Thr Lys Ser Glu Asp Thr Ile Ser Lys Met Asn Asp Phe Met 
            500                 505                 510         


Arg Met Gln Ile Leu Lys Glu Gly Ser His Phe Pro Gly Pro Phe Met 
        515                 520                 525             


Thr Ser Ile Gly Pro Ala Glu Ser His Pro His Thr Pro Gln Met Pro 
    530                 535                 540                 


Pro Ser Thr Pro Ser Ser Ser Phe Leu Thr Thr Leu Lys Pro Arg Leu 
545                 550                 555                 560 


Lys Thr Glu Pro Glu Glu Val Ser Ile Glu Asp Ser Ala Gln Ser Asp 
                565                 570                 575     


Leu Lys Glu Val Met Val Leu Asn Ala Thr Glu Ser Phe Val Tyr Glu 
            580                 585                 590         


Pro Lys Glu Gln Lys Lys Met Phe His Ala Thr Val Ala Thr Glu Asn 
        595                 600                 605             


Glu Val Phe Arg Val Lys Val Phe Asn Ile Asp Leu Lys Glu Lys Phe 
    610                 615                 620                 


Thr Pro Lys Lys Ile Ile Ala Ile Ala Asn Tyr Val Cys Arg Asn Gly 
625                 630                 635                 640 


Phe Leu Glu Val Tyr Pro Phe Thr Leu Val Ala Asp Val Asn Ala Asp 
                645                 650                 655     


Arg Asn Met Glu Ile Pro Lys Gly Leu Ile Arg Ser Ala Ser Val Thr 
            660                 665                 670         


Pro Lys Ile Asn Gln Leu Cys Ser Gln Thr Lys Gly Ser Phe Val Asn 
        675                 680                 685             


Gly Val Phe Glu Val His Lys Lys Asn Val Arg Gly Glu Phe Thr Tyr 
    690                 695                 700                 


Tyr Glu Ile Gln Asp Asn Thr Gly Lys Met Glu Val Val Val His Gly 
705                 710                 715                 720 


Arg Leu Thr Thr Ile Asn Cys Glu Glu Gly Asp Lys Leu Lys Leu Thr 
                725                 730                 735     


Cys Phe Glu Leu Ala Pro Lys Ser Gly Asn Thr Gly Glu Leu Arg Ser 
            740                 745                 750         


Val Ile His Ser His Ile Lys Val Ile Lys Thr Arg Lys Asn Lys Lys 
        755                 760                 765             


Asp Ile Leu Asn Pro Asp Ser Ser Met Glu Thr Ser Pro Asp Phe Phe 
    770                 775                 780                 


Phe 
785 


<210> 3
<211> 619
<212> PRT
<213> Mus musculus

<400> 3
Met Val Asn Glu Tyr Lys Arg Ile Val Leu Leu Arg Gly Leu Glu Cys 
1               5                   10                  15      


Ile Asn Lys His Tyr Phe Ser Leu Phe Lys Ser Leu Leu Ala Arg Asp 
            20                  25                  30          


Leu Asn Leu Glu Arg Asp Asn Gln Glu Gln Tyr Thr Thr Ile Gln Ile 
        35                  40                  45              


Ala Asn Met Met Glu Glu Lys Phe Pro Ala Asp Ser Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Ala Phe Cys Glu Glu Val Pro Ala Leu Arg Lys Arg Ala Glu 
65                  70                  75                  80  


Ile Leu Lys Lys Glu Arg Ser Glu Val Thr Gly Glu Thr Ser Leu Glu 
                85                  90                  95      


Lys Asn Gly Gln Glu Ala Gly Pro Ala Thr Pro Thr Ser Thr Thr Ser 
            100                 105                 110         


His Met Leu Ala Ser Glu Arg Gly Glu Thr Ser Ala Thr Gln Glu Glu 
        115                 120                 125             


Thr Ser Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Ala Arg Thr Ser 
    130                 135                 140                 


Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Lys Arg Lys Ile Met Arg 
145                 150                 155                 160 


Glu Glu Glu Thr Gly Val Lys Lys Ser Lys Ala Ala Lys Glu Pro Asp 
                165                 170                 175     


Gln Pro Pro Cys Cys Glu Glu Pro Thr Ala Arg Cys Gln Ser Pro Ile 
            180                 185                 190         


Leu His Ser Ser Ser Ser Ala Ser Ser Asn Ile Pro Ser Ala Lys Asn 
        195                 200                 205             


Gln Lys Ser Gln Pro Gln Asn Gln Asn Ile Pro Arg Gly Ala Val Leu 
    210                 215                 220                 


His Ser Glu Pro Leu Thr Val Met Val Leu Thr Ala Thr Asp Pro Phe 
225                 230                 235                 240 


Glu Tyr Glu Ser Pro Glu His Glu Val Lys Asn Met Leu His Ala Thr 
                245                 250                 255     


Val Ala Thr Val Ser Gln Tyr Phe His Val Lys Val Phe Asn Ile Asn 
            260                 265                 270         


Leu Lys Glu Lys Phe Thr Lys Lys Asn Phe Ile Ile Ile Ser Asn Tyr 
        275                 280                 285             


Phe Glu Ser Lys Gly Ile Leu Glu Ile Asn Glu Thr Ser Ser Val Leu 
    290                 295                 300                 


Glu Ala Ala Pro Asp Gln Met Ile Glu Val Pro Asn Ser Ile Ile Arg 
305                 310                 315                 320 


Asn Ala Asn Ala Ser Pro Lys Ile Cys Asp Ile Gln Lys Gly Thr Ser 
                325                 330                 335     


Gly Ala Val Phe Tyr Gly Val Phe Thr Leu His Lys Lys Thr Val Asn 
            340                 345                 350         


Arg Lys Asn Thr Ile Tyr Glu Ile Lys Asp Gly Ser Gly Ser Ile Glu 
        355                 360                 365             


Val Val Gly Ser Gly Lys Trp His Asn Ile Asn Cys Lys Glu Gly Asp 
    370                 375                 380                 


Lys Leu His Leu Phe Cys Phe His Leu Lys Thr Ile Asp Arg Gln Pro 
385                 390                 395                 400 


Lys Leu Val Cys Gly Glu His Ser Phe Ile Lys Ile Ser Lys Arg Gly 
                405                 410                 415     


Asn Val Pro Lys Glu Pro Ala Lys Glu Glu Asp His His His Gly Pro 
            420                 425                 430         


Lys Gln Val Met Val Leu Lys Val Thr Glu Pro Phe Thr Tyr Asp Leu 
        435                 440                 445             


Lys Glu Asp Lys Arg Met Phe His Ala Thr Val Ala Thr Glu Thr Glu 
    450                 455                 460                 


Phe Phe Arg Val Lys Val Phe Asp Thr Ala Leu Lys Ser Lys Phe Ile 
465                 470                 475                 480 


Pro Arg Asn Ile Ile Ala Ile Ser Asp Tyr Phe Gly Cys Asn Gly Phe 
                485                 490                 495     


Leu Glu Ile Tyr Arg Ala Ser Cys Val Ser Asp Val Asn Val Asn Pro 
            500                 505                 510         


Thr Met Val Ile Ser Asn Thr Leu Arg Gln Arg Ala Asn Ala Thr Pro 
        515                 520                 525             


Lys Ile Ser Tyr Leu Phe Ser Gln Ala Arg Gly Thr Phe Val Ser Gly 
    530                 535                 540                 


Glu Tyr Leu Val Asn Lys Lys Thr Glu Arg Asn Lys Phe Ile Tyr Tyr 
545                 550                 555                 560 


Gly Ile Gly Asp Asp Thr Gly Lys Met Glu Val Val Val Tyr Gly Arg 
                565                 570                 575     


Leu Thr Asn Val Arg Cys Glu Pro Gly Ser Lys Leu Arg Leu Val Cys 
            580                 585                 590         


Phe Glu Leu Thr Ser Thr Glu Asp Gly Trp Gln Leu Arg Ser Val Arg 
        595                 600                 605             


His Ser Tyr Met Gln Val Ile Asn Ala Arg Lys 
    610                 615                 


<210> 4
<211> 619
<212> PRT
<213> Mus musculus

<400> 4
Met Val Asn Glu Tyr Lys Arg Ile Val Leu Leu Ala Gly Leu Glu Cys 
1               5                   10                  15      


Ile Asn Lys His Tyr Phe Ser Leu Phe Lys Ser Leu Leu Ala Arg Asp 
            20                  25                  30          


Leu Asn Leu Glu Arg Asp Asn Gln Glu Gln Tyr Thr Thr Ile Gln Ile 
        35                  40                  45              


Ala Asn Met Met Glu Glu Lys Phe Pro Ala Asp Ser Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Ala Phe Cys Glu Glu Val Pro Ala Leu Arg Lys Arg Ala Glu 
65                  70                  75                  80  


Ile Leu Lys Lys Glu Arg Ser Glu Val Thr Gly Glu Thr Ser Leu Glu 
                85                  90                  95      


Lys Asn Gly Gln Glu Ala Gly Pro Ala Thr Pro Thr Ser Thr Thr Ser 
            100                 105                 110         


His Met Leu Ala Ser Glu Arg Gly Glu Thr Ser Ala Thr Gln Glu Glu 
        115                 120                 125             


Thr Ser Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Ala Arg Thr Ser 
    130                 135                 140                 


Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Lys Arg Lys Ile Met Arg 
145                 150                 155                 160 


Glu Glu Glu Thr Gly Val Lys Lys Ser Lys Ala Ala Lys Glu Pro Asp 
                165                 170                 175     


Gln Pro Pro Cys Cys Glu Glu Pro Thr Ala Arg Cys Gln Ser Pro Ile 
            180                 185                 190         


Leu His Ser Ser Ser Ser Ala Ser Ser Asn Ile Pro Ser Ala Lys Asn 
        195                 200                 205             


Gln Lys Ser Gln Pro Gln Asn Gln Asn Ile Pro Arg Gly Ala Val Leu 
    210                 215                 220                 


His Ser Glu Pro Leu Thr Val Met Val Leu Thr Ala Thr Asp Pro Phe 
225                 230                 235                 240 


Glu Tyr Glu Ser Pro Glu His Glu Val Lys Asn Met Leu His Ala Thr 
                245                 250                 255     


Val Ala Thr Val Ser Gln Tyr Phe His Val Lys Val Phe Asn Ile Asn 
            260                 265                 270         


Leu Lys Glu Lys Phe Thr Lys Lys Asn Phe Ile Ile Ile Ser Asn Tyr 
        275                 280                 285             


Phe Glu Ser Lys Gly Ile Leu Glu Ile Asn Glu Thr Ser Ser Val Leu 
    290                 295                 300                 


Glu Ala Ala Pro Asp Gln Met Ile Glu Val Pro Asn Ser Ile Ile Arg 
305                 310                 315                 320 


Asn Ala Asn Ala Ser Pro Lys Ile Cys Asp Ile Gln Lys Gly Thr Ser 
                325                 330                 335     


Gly Ala Val Phe Tyr Gly Val Phe Thr Leu His Lys Lys Thr Val Asn 
            340                 345                 350         


Arg Lys Asn Thr Ile Tyr Glu Ile Lys Asp Gly Ser Gly Ser Ile Glu 
        355                 360                 365             


Val Val Gly Ser Gly Lys Trp His Asn Ile Asn Cys Lys Glu Gly Asp 
    370                 375                 380                 


Lys Leu His Leu Phe Cys Phe His Leu Lys Thr Ile Asp Arg Gln Pro 
385                 390                 395                 400 


Lys Leu Val Cys Gly Glu His Ser Phe Ile Lys Ile Ser Lys Arg Gly 
                405                 410                 415     


Asn Val Pro Lys Glu Pro Ala Lys Glu Glu Asp His His His Gly Pro 
            420                 425                 430         


Lys Gln Val Met Val Leu Lys Val Thr Glu Pro Phe Thr Tyr Asp Leu 
        435                 440                 445             


Lys Glu Asp Lys Arg Met Phe His Ala Thr Val Ala Thr Glu Thr Glu 
    450                 455                 460                 


Phe Phe Arg Val Lys Val Phe Asp Thr Ala Leu Lys Ser Lys Phe Ile 
465                 470                 475                 480 


Pro Arg Asn Ile Ile Ala Ile Ser Asp Tyr Phe Gly Cys Asn Gly Phe 
                485                 490                 495     


Leu Glu Ile Tyr Arg Ala Ser Cys Val Ser Asp Val Asn Val Asn Pro 
            500                 505                 510         


Thr Met Val Ile Ser Asn Thr Leu Arg Gln Arg Ala Asn Ala Thr Pro 
        515                 520                 525             


Lys Ile Ser Tyr Leu Phe Ser Gln Ala Arg Gly Thr Phe Val Ser Gly 
    530                 535                 540                 


Glu Tyr Leu Val Asn Lys Lys Thr Glu Arg Asn Lys Phe Ile Tyr Tyr 
545                 550                 555                 560 


Gly Ile Gly Asp Asp Thr Gly Lys Met Glu Val Val Val Tyr Gly Arg 
                565                 570                 575     


Leu Thr Asn Val Arg Cys Glu Pro Gly Ser Lys Leu Arg Leu Val Cys 
            580                 585                 590         


Phe Glu Leu Thr Ser Thr Glu Asp Gly Trp Gln Leu Arg Ser Val Arg 
        595                 600                 605             


His Ser Tyr Met Gln Val Ile Asn Ala Arg Lys 
    610                 615                 


<210> 5
<211> 619
<212> PRT
<213> Mus musculus

<400> 5
Met Val Asn Glu Tyr Lys Arg Ile Val Leu Leu Arg Gly Leu Glu Cys 
1               5                   10                  15      


Ile Asn Lys His Tyr Phe Ser Leu Phe Lys Ser Leu Leu Ala Arg Asp 
            20                  25                  30          


Leu Asn Leu Glu Arg Asp Asn Gln Glu Gln Tyr Thr Thr Ile Gln Ile 
        35                  40                  45              


Ala Asn Met Met Glu Glu Lys Phe Pro Ala Asp Ser Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Ala Phe Cys Glu Glu Val Pro Ala Leu Arg Lys Arg Ala Glu 
65                  70                  75                  80  


Ile Leu Lys Lys Glu Arg Ser Glu Val Thr Gly Glu Thr Ser Leu Glu 
                85                  90                  95      


Lys Asn Gly Gln Glu Ala Gly Pro Ala Thr Pro Thr Ser Thr Thr Ser 
            100                 105                 110         


His Met Leu Ala Ser Glu Arg Gly Glu Thr Ser Ala Thr Gln Glu Glu 
        115                 120                 125             


Thr Ser Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Ala Arg Thr Ser 
    130                 135                 140                 


Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Lys Arg Lys Ile Met Arg 
145                 150                 155                 160 


Glu Glu Glu Thr Gly Val Lys Lys Ser Lys Ala Ala Lys Glu Pro Asp 
                165                 170                 175     


Gln Pro Pro Cys Cys Glu Glu Pro Thr Ala Arg Cys Gln Ser Pro Ile 
            180                 185                 190         


Leu His Ser Ser Ser Ser Ala Ser Ser Asn Ile Pro Ser Ala Lys Asn 
        195                 200                 205             


Gln Lys Ser Gln Pro Gln Asn Gln Asn Ile Pro Arg Gly Ala Val Leu 
    210                 215                 220                 


His Ser Glu Pro Leu Thr Val Met Val Leu Thr Ala Thr Asp Pro Phe 
225                 230                 235                 240 


Glu Tyr Glu Ser Pro Glu His Glu Val Lys Asn Met Leu His Ala Thr 
                245                 250                 255     


Val Ala Thr Val Ser Gln Tyr Phe His Val Lys Val Phe Asn Ile Asn 
            260                 265                 270         


Leu Lys Glu Lys Phe Thr Lys Lys Asn Phe Ile Ile Ile Ser Asn Tyr 
        275                 280                 285             


Phe Glu Ser Lys Gly Ile Leu Glu Ile Asn Glu Thr Ser Ser Val Leu 
    290                 295                 300                 


Glu Ala Ala Pro Asp Gln Met Ile Glu Val Pro Asn Ser Ile Ile Arg 
305                 310                 315                 320 


Asn Ala Asn Ala Ser Pro Lys Ile Cys Asp Ile Gln Lys Gly Thr Ser 
                325                 330                 335     


Gly Ala Val Phe Tyr Gly Val Phe Thr Leu His Lys Lys Thr Val Asn 
            340                 345                 350         


Arg Lys Asn Thr Ile Tyr Glu Ile Lys Asp Gly Ser Gly Ser Ile Glu 
        355                 360                 365             


Val Val Gly Ser Gly Lys Trp His Asn Ile Asn Cys Lys Glu Gly Asp 
    370                 375                 380                 


Lys Leu His Leu Phe Cys Phe His Leu Lys Thr Ile Asp Arg Gln Pro 
385                 390                 395                 400 


Lys Leu Val Cys Gly Glu His Ser Phe Ile Lys Ile Ser Lys Arg Gly 
                405                 410                 415     


Asn Val Pro Lys Glu Pro Ala Lys Glu Glu Asp His His His Gly Pro 
            420                 425                 430         


Lys Gln Val Met Val Leu Lys Val Thr Glu Pro Phe Thr Tyr Asp Leu 
        435                 440                 445             


Lys Glu Asp Lys Arg Met Phe His Ala Thr Val Ala Thr Glu Thr Glu 
    450                 455                 460                 


Phe Phe Arg Val Lys Val Phe Asp Thr Ala Leu Lys Ser Lys Phe Ile 
465                 470                 475                 480 


Pro Arg Asn Ile Ile Ala Ile Ser Asp Tyr Phe Gly Cys Asn Gly Phe 
                485                 490                 495     


Leu Glu Ile Tyr Arg Ala Ser Cys Val Ser Asp Val Asn Val Asn Pro 
            500                 505                 510         


Thr Met Val Ile Ser Asn Thr Leu Arg Gln Arg Ala Asn Ala Thr Pro 
        515                 520                 525             


Lys Ile Ser Tyr Leu Phe Ser Gln Ala Ala Gly Thr Phe Val Ser Gly 
    530                 535                 540                 


Glu Tyr Leu Val Asn Lys Lys Thr Glu Arg Asn Lys Phe Ile Tyr Tyr 
545                 550                 555                 560 


Gly Ile Gly Asp Asp Thr Gly Lys Met Glu Val Val Val Tyr Gly Arg 
                565                 570                 575     


Leu Thr Asn Val Arg Cys Glu Pro Gly Ser Lys Leu Arg Leu Val Cys 
            580                 585                 590         


Phe Glu Leu Thr Ser Thr Glu Asp Gly Trp Gln Leu Arg Ser Val Arg 
        595                 600                 605             


His Ser Tyr Met Gln Val Ile Asn Ala Arg Lys 
    610                 615                 


<210> 6
<211> 619
<212> PRT
<213> Mus musculus

<400> 6
Met Val Asn Glu Tyr Lys Arg Ile Val Leu Leu Ala Gly Leu Glu Cys 
1               5                   10                  15      


Ile Asn Lys His Tyr Phe Ser Leu Phe Lys Ser Leu Leu Ala Arg Asp 
            20                  25                  30          


Leu Asn Leu Glu Arg Asp Asn Gln Glu Gln Tyr Thr Thr Ile Gln Ile 
        35                  40                  45              


Ala Asn Met Met Glu Glu Lys Phe Pro Ala Asp Ser Gly Leu Gly Lys 
    50                  55                  60                  


Leu Ile Ala Phe Cys Glu Glu Val Pro Ala Leu Arg Lys Arg Ala Glu 
65                  70                  75                  80  


Ile Leu Lys Lys Glu Arg Ser Glu Val Thr Gly Glu Thr Ser Leu Glu 
                85                  90                  95      


Lys Asn Gly Gln Glu Ala Gly Pro Ala Thr Pro Thr Ser Thr Thr Ser 
            100                 105                 110         


His Met Leu Ala Ser Glu Arg Gly Glu Thr Ser Ala Thr Gln Glu Glu 
        115                 120                 125             


Thr Ser Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Ala Arg Thr Ser 
    130                 135                 140                 


Thr Ala Gln Ala Gly Thr Ser Thr Ala Gln Lys Arg Lys Ile Met Arg 
145                 150                 155                 160 


Glu Glu Glu Thr Gly Val Lys Lys Ser Lys Ala Ala Lys Glu Pro Asp 
                165                 170                 175     


Gln Pro Pro Cys Cys Glu Glu Pro Thr Ala Arg Cys Gln Ser Pro Ile 
            180                 185                 190         


Leu His Ser Ser Ser Ser Ala Ser Ser Asn Ile Pro Ser Ala Lys Asn 
        195                 200                 205             


Gln Lys Ser Gln Pro Gln Asn Gln Asn Ile Pro Arg Gly Ala Val Leu 
    210                 215                 220                 


His Ser Glu Pro Leu Thr Val Met Val Leu Thr Ala Thr Asp Pro Phe 
225                 230                 235                 240 


Glu Tyr Glu Ser Pro Glu His Glu Val Lys Asn Met Leu His Ala Thr 
                245                 250                 255     


Val Ala Thr Val Ser Gln Tyr Phe His Val Lys Val Phe Asn Ile Asn 
            260                 265                 270         


Leu Lys Glu Lys Phe Thr Lys Lys Asn Phe Ile Ile Ile Ser Asn Tyr 
        275                 280                 285             


Phe Glu Ser Lys Gly Ile Leu Glu Ile Asn Glu Thr Ser Ser Val Leu 
    290                 295                 300                 


Glu Ala Ala Pro Asp Gln Met Ile Glu Val Pro Asn Ser Ile Ile Arg 
305                 310                 315                 320 


Asn Ala Asn Ala Ser Pro Lys Ile Cys Asp Ile Gln Lys Gly Thr Ser 
                325                 330                 335     


Gly Ala Val Phe Tyr Gly Val Phe Thr Leu His Lys Lys Thr Val Asn 
            340                 345                 350         


Arg Lys Asn Thr Ile Tyr Glu Ile Lys Asp Gly Ser Gly Ser Ile Glu 
        355                 360                 365             


Val Val Gly Ser Gly Lys Trp His Asn Ile Asn Cys Lys Glu Gly Asp 
    370                 375                 380                 


Lys Leu His Leu Phe Cys Phe His Leu Lys Thr Ile Asp Arg Gln Pro 
385                 390                 395                 400 


Lys Leu Val Cys Gly Glu His Ser Phe Ile Lys Ile Ser Lys Arg Gly 
                405                 410                 415     


Asn Val Pro Lys Glu Pro Ala Lys Glu Glu Asp His His His Gly Pro 
            420                 425                 430         


Lys Gln Val Met Val Leu Lys Val Thr Glu Pro Phe Thr Tyr Asp Leu 
        435                 440                 445             


Lys Glu Asp Lys Arg Met Phe His Ala Thr Val Ala Thr Glu Thr Glu 
    450                 455                 460                 


Phe Phe Arg Val Lys Val Phe Asp Thr Ala Leu Lys Ser Lys Phe Ile 
465                 470                 475                 480 


Pro Arg Asn Ile Ile Ala Ile Ser Asp Tyr Phe Gly Cys Asn Gly Phe 
                485                 490                 495     


Leu Glu Ile Tyr Arg Ala Ser Cys Val Ser Asp Val Asn Val Asn Pro 
            500                 505                 510         


Thr Met Val Ile Ser Asn Thr Leu Arg Gln Arg Ala Asn Ala Thr Pro 
        515                 520                 525             


Lys Ile Ser Tyr Leu Phe Ser Gln Ala Ala Gly Thr Phe Val Ser Gly 
    530                 535                 540                 


Glu Tyr Leu Val Asn Lys Lys Thr Glu Arg Asn Lys Phe Ile Tyr Tyr 
545                 550                 555                 560 


Gly Ile Gly Asp Asp Thr Gly Lys Met Glu Val Val Val Tyr Gly Arg 
                565                 570                 575     


Leu Thr Asn Val Arg Cys Glu Pro Gly Ser Lys Leu Arg Leu Val Cys 
            580                 585                 590         


Phe Glu Leu Thr Ser Thr Glu Asp Gly Trp Gln Leu Arg Ser Val Arg 
        595                 600                 605             


His Ser Tyr Met Gln Val Ile Asn Ala Arg Lys 
    610                 615                 


<210> 7
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ccatcagaaa gaggtttaat atttttgtga gaccatcggg gccgcgcctc ccccgcgagg       60

ccgccggcg                                                               69


<210> 8
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
tgtggccctc cgtgaaatc                                                    19


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
ggcataattg ttacacgttt ggc                                               23


<210> 10
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
ccaagtgctg ccgtcatttt c                                                 21


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
ggctcgcagg gatgatttca a                                                 21


<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
ctcaccatat ggctcggaca                                                   20


<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
cttctctggg ttggcacaca                                                   20


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
cagctccaag aaaggacgaa c                                                 21


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
ggcagtgtaa ctcttctgca t                                                 21


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
gtgccaaacg tccttttcag a                                                 21


<210> 17
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
agtgaggagt aagccatgct c                                                 21


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
ggacttgcct tgttccgaga g                                                 21


<210> 19
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
gctgccacat aactgatagc ga                                                22


<210> 20
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ttctggtgct tgtctcactg a                                                 21


<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
cagtatgttc ggcttcccat tc                                                22


<210> 22
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
catgaaccga gatggctcta gt                                                22


<210> 23
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
tcatcgtaga attttggcag ctc                                               23


<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
gagcaaggcg gctaaggaa                                                    19


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
gctgtggagt attggtgact g                                                 21


<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
ctgaattgcg tccccgaaat a                                                 21


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
aggttcctga atgaactccc t                                                 21


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
cttgctgtgc tggattcaag c                                                 21


<210> 29
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
caactgtggt aagaagggag tg                                                22


<210> 30
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
tggggcctaa gcctatgtct                                                   20


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
ctcccaaggg tggctttagg                                                   20


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 32
ctgccgatac tgaacctgag c                                                 21


<210> 33
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 33
gcggtcaaaa tcgcactcc                                                    19


<210> 34
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 34
His His His His His His 
1               5       


